category	mir	disease	pmid	root_name	doid	icd10cm	mesh	omim	hpo	description
tissue_expression_down	hsa-mir-150	Acquired Immunodeficiency Syndrome	22205749	disease by infectious agent	DOID:635	B20	D000163	609423		we used microarray expression analysis to identify miRNAs miR-27b, miR-29b, miR-150, and miR-223 as being significantly downregulated upon CD4(+) T cell activation
tissue_expression_down	hsa-mir-223	Acquired Immunodeficiency Syndrome	22205749	disease by infectious agent	DOID:635	B20	D000163	609423		we used microarray expression analysis to identify miRNAs miR-27b, miR-29b, miR-150, and miR-223 as being significantly downregulated upon CD4(+) T cell activation
tissue_expression_down	hsa-mir-27b	Acquired Immunodeficiency Syndrome	22205749	disease by infectious agent	DOID:635	B20	D000163	609423		we used microarray expression analysis to identify miRNAs miR-27b, miR-29b, miR-150, and miR-223 as being significantly downregulated upon CD4(+) T cell activation
tissue_expression_down	hsa-mir-29b	Acquired Immunodeficiency Syndrome	22205749	disease by infectious agent	DOID:635	B20	D000163	609423		we used microarray expression analysis to identify miRNAs miR-27b, miR-29b, miR-150, and miR-223 as being significantly downregulated upon CD4(+) T cell activation
tissue_expression_down	hsa-mir-126	Acute Myocardial Infarction	27376405	cardiovascular system disease	DOID:9408	I21	D056989	608446	HP:0001658	Down-regulated miR-126 and up-regulated VEGF-A were also observed in MI models
tissue_expression_down	hsa-mir-499a	Acute Myocardial Infarction	26046358	cardiovascular system disease	DOID:9408	I21	D056989	608446	HP:0001658	This study highlights the stability of miRNAs after death and long-term fixation, validating their use as reliable biomarkers for AMI during postmortem examination.
tissue_expression_down	hsa-mir-24	Acute Respiratory Distress Syndrome	25070658	respiratory system disease	DOID:11394	J80	D012128			The down-regulated miRNAs included miR-24, miR-26a, miR-126, and Let-7a, b, c, f. The up-regulated miRNAs were composed of miR-344, miR-346, miR-99a, miR-127, miR-128b, miR-135b, and miR-30a/b.
tissue_expression_down	hsa-mir-1268	Adenocarcinoma, Colon	27658891	disease of cellular proliferation	DOID:234	C18			HP:0040276	the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -326b (downregulated)
tissue_expression_down	hsa-mir-1275	Adenocarcinoma, Colon	27658891	disease of cellular proliferation	DOID:234	C18			HP:0040276	the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -326b (downregulated)
tissue_expression_down	hsa-mir-320b	Adenocarcinoma, Colon	27658891	disease of cellular proliferation	DOID:234	C18			HP:0040276	the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -326b (downregulated)
tissue_expression_down	hsa-mir-326b	Adenocarcinoma, Colon	27658891	disease of cellular proliferation	DOID:234	C18			HP:0040276	the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -326b (downregulated)
tissue_expression_down	hsa-mir-663	Adenocarcinoma, Colon	27658891	disease of cellular proliferation	DOID:234	C18			HP:0040276	the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -325b (downregulated)
tissue_expression_down	hsa-mir-10b	Adenocarcinoma, Endometrial	19891660	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	down-regulated
tissue_expression_down	hsa-mir-152	Adenocarcinoma, Endometrial	19891660	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	down-regulated
tissue_expression_down	hsa-mir-193b	Adenocarcinoma, Endometrial	19077565	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-193b: downregulated
tissue_expression_down	hsa-mir-204	Adenocarcinoma, Endometrial	19077565	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-204: downregulated
tissue_expression_down	hsa-mir-410	Adenocarcinoma, Endometrial	26842619	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	a lower expression of microRNA-410 in the  cancer zone compared with the healthy zone
tissue_expression_down	hsa-mir-99b	Adenocarcinoma, Endometrial	19077565	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-99b: downregulated
tissue_expression_down	hsa-mir-17	Adenocarcinoma, Esophageal	28002789	disease of cellular proliferation	DOID:4914		C562730	133239		MicroRNA-17 is downregulated in esophageal adenocarcinoma cancer stem-like cells and promotes a radioresistant phenotype.
tissue_expression_down	hsa-mir-205	Adenocarcinoma, Esophageal	25746664	disease of cellular proliferation	DOID:4914		C562730	133239		miRs such as miR-192, miR-196 and miR-21 were frequently noted to up-regulated whereas miR-203, miR-205 and miR-let-7 were commonly down-regulated during the development of Barrett's oesophagus to oesophageal adenocarcinoma.
tissue_expression_down	hsa-mir-216b	Adenocarcinoma, Gastric	26408293	disease of cellular proliferation	DOID:3717	D37.1	D013274			We reported a significantly decreased expression of miR-216b in GC clinical specimens compared with paired non-cancerous tissues.
tissue_expression_down	hsa-mir-299	Adenocarcinoma, Gastric	27007598	disease of cellular proliferation	DOID:3717	D37.1	D013274			significant downregulation of miR-299-5p in intestinal-type gastric adenocarcinoma
tissue_expression_down	hsa-mir-302b	Adenocarcinoma, Gastric	23508453	disease of cellular proliferation	DOID:3717	D37.1	D013274			Down-regulation of miR-302b, an ESC-specific microRNA, in Gastric Adenocarcinoma.
tissue_expression_down	hsa-mir-375	Adenocarcinoma, Gastric	23461060	disease of cellular proliferation	DOID:3717	D37.1	D013274			In our study, the expression of a subset of microRNAs was altered in distal gastric adenocarcinoma compared to normal tissue, miR-375 was significantly downregulated in distal gastric adenocarcinoma tissues, to a level that was significantly lower than cardia adenocarcinoma (p < 0.05).
tissue_expression_down	hsa-mir-124	Adenocarcinoma, Lung	26935152	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	miR-124 was significantly downregulated in the lung ADC tissues compared with that noted in the corresponding non-cancerous lung tissues
tissue_expression_down	hsa-mir-485	Adenocarcinoma, Lung	27262438	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	expression level of miR-485 was downregulated in four lung adenocarcinoma cell lines and tissue
tissue_expression_down	hsa-mir-124	Adenocarcinoma, Pancreatic Ductal	27922430	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		Downregulation of miR-124 predicts poor prognosis in pancreatic ductal adenocarcinoma patients.
tissue_expression_down	hsa-mir-133a	Adenocarcinoma, Pancreatic Ductal	17237814	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		The expression of miR-216 and -217 and lack of expression of miR-133a were identified as characteristic of pancreas tissue.
tissue_expression_down	hsa-mir-15a	Adenocarcinoma, Pancreatic Ductal	24252251	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		miR-15a inhibits cell proliferation and EMT in PDAC via the down-regulation of Bmi-1 expression.
tissue_expression_down	hsa-mir-218	Adenocarcinoma, Pancreatic Ductal	24166773	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		Reduced miR-218 in PDAC tissues was correlated with tumor progression, and might be an independent poor prognostic factor for patients.
tissue_expression_down	hsa-mir-301a	Adenocarcinoma, Pancreatic Ductal	26384137	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		We conclude that MnSOD expression is negatively associated with miR-301a levels in PDAC tissues, and lower miR-301a levels are associated with increased MnSOD expression and inhibition of PDAC growth.
tissue_expression_down	hsa-mir-337	Adenocarcinoma, Pancreatic Ductal	24641834	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		The present study showed that HOXB7 was over-expressed and miR-337 was minimally expressed in PDAC tissues, and their levels were related to TNM stage and lymph node status. The levels of HOXB7 mRNA, HOXB7 protein, and miR-337 were associated with survival in PDAC patients. Results suggested that HOXB7 and miR-337 could be used as determinants of PDAC patient prognosis.
tissue_expression_down	hsa-let-7e	Adenovirus Infection	20634878			B34.0	D000257			let-7e:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-101-1	Adenovirus Infection	20634878			B34.0	D000257			miR-101-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-101-2	Adenovirus Infection	20634878			B34.0	D000257			miR-101-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-1180	Adenovirus Infection	20634878			B34.0	D000257			hsa-mir-1180:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-1184-1	Adenovirus Infection	20634878			B34.0	D000257			miR-1184:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-125b-1	Adenovirus Infection	20634878			B34.0	D000257			miR-125b-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-125b-2	Adenovirus Infection	20634878			B34.0	D000257			miR-125b-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-148a	Adenovirus Infection	20634878			B34.0	D000257			miR-148a:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-148b	Adenovirus Infection	20634878			B34.0	D000257			miR-148b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-181b-1	Adenovirus Infection	20634878			B34.0	D000257			miR-181b-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-181b-2	Adenovirus Infection	20634878			B34.0	D000257			miR-181b-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-18b	Adenovirus Infection	20634878			B34.0	D000257			miR-18b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-196b	Adenovirus Infection	20634878			B34.0	D000257			miR-196b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-19b-1	Adenovirus Infection	20634878			B34.0	D000257			miR-19b-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-19b-2	Adenovirus Infection	20634878			B34.0	D000257			miR-19b-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-210	Adenovirus Infection	20634878			B34.0	D000257			miR-210:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-219-1	Adenovirus Infection	20634878			B34.0	D000257			miR-219-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-25	Adenovirus Infection	20634878			B34.0	D000257			miR-25:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-26b	Adenovirus Infection	20634878			B34.0	D000257			miR-26b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-27a	Adenovirus Infection	20634878			B34.0	D000257			miR-27a:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-27b	Adenovirus Infection	20634878			B34.0	D000257			miR-27b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-30a	Adenovirus Infection	20634878			B34.0	D000257			miR-30a:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-30b	Adenovirus Infection	20634878			B34.0	D000257			miR-30b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-30c-1	Adenovirus Infection	20634878			B34.0	D000257			miR-30c-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-30c-2	Adenovirus Infection	20634878			B34.0	D000257			miR-30c-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-338	Adenovirus Infection	20634878			B34.0	D000257			miR-338:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-33a	Adenovirus Infection	20634878			B34.0	D000257			miR-33a:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-34a	Adenovirus Infection	20634878			B34.0	D000257			miR-34a:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-362	Adenovirus Infection	20634878			B34.0	D000257			miR-362:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-374b	Adenovirus Infection	20634878			B34.0	D000257			miR-374b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-421	Adenovirus Infection	20634878			B34.0	D000257			miR-421:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-433	Adenovirus Infection	20634878			B34.0	D000257			miR-433:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-452	Adenovirus Infection	20634878			B34.0	D000257			miR-452:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-519a-1	Adenovirus Infection	20634878			B34.0	D000257			miR-519a-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-582	Adenovirus Infection	20634878			B34.0	D000257			miR-582:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-619	Adenovirus Infection	20634878			B34.0	D000257			miR-619:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-650	Adenovirus Infection	20634878			B34.0	D000257			miR-650:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-655	Adenovirus Infection	20634878			B34.0	D000257			miR-655:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-92a-2	Adenovirus Infection	20634878			B34.0	D000257			miR-92a-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_down	hsa-mir-200b	Adrenal Cortex Neoplasms	19849700	disease of cellular proliferation	DOID:0050891	C74.0	D000306		HP:0100641	down-regulated
tissue_expression_down	hsa-mir-203	Adrenal Cortex Neoplasms	19849700	disease of cellular proliferation	DOID:0050891	C74.0	D000306		HP:0100641	down-regulated
tissue_expression_down	hsa-mir-214	Adrenal Cortex Neoplasms	19546168	disease of cellular proliferation	DOID:0050891	C74.0	D000306		HP:0100641	significantly lower expressed
tissue_expression_down	hsa-mir-195	Adrenal Cortex Neoplasms	19996210	disease of cellular proliferation	DOID:0050891	C74.0	D000306		HP:0100641	miR-335 and miR-195 were significantly downregulated in adrenocortical carcinomas
tissue_expression_down	hsa-mir-483	Adrenal Cortex Neoplasms	19996210	disease of cellular proliferation	DOID:0050891	C74.0	D000306		HP:0100641	miR-335 and miR-195 were significantly downregulated in adrenocortical carcinomas
tissue_expression_down	hsa-mir-21	Alcoholic Cardiomyopathy	29039471			I42.6	D002310			The present study confirmed that H2S relieves myocardial fibrosis in mice with ACM, and the underlying mechanism may involve the downregulation of autophagy and miR-21 and miR-211 expression levels.
tissue_expression_down	hsa-mir-221	Alcoholic Cardiomyopathy	29039471			I42.6	D002310			The present study confirmed that H2S relieves myocardial fibrosis in mice with ACM, and the underlying mechanism may involve the downregulation of autophagy and miR-21 and miR-211 expression levels.
tissue_expression_down	hsa-mir-3098	Alcoholic Cardiomyopathy	29734191			I42.6	D002310			The results demonstrated that miR-467d-3p and miR-491-5p were up-regulated and miR-3098-3p was down-regulated in the alcohol-exposed myocardial samples compared with the control samples (P < 0.05).
tissue_expression_down	hsa-let-7e	Allergic Rhinitis	23704072	respiratory system disease	DOID:4481	J30.9	D065631	607154	HP:0003193	Subjects with current allergic rhinitis symptoms had increased levels of miR-155, miR-205, and miR-498, but reduced levels of let-7e.
tissue_expression_down	hsa-let-7e	Allergic Rhinitis	24513959	respiratory system disease	DOID:4481	J30.9	D065631	607154	HP:0003193	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_down	hsa-mir-126	Allergic Rhinitis	24513959	respiratory system disease	DOID:4481	J30.9	D065631	607154	HP:0003193	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_down	hsa-mir-155	Allergic Rhinitis	24513959	respiratory system disease	DOID:4481	J30.9	D065631	607154	HP:0003193	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_down	hsa-mir-18a	Allergic Rhinitis	24513959	respiratory system disease	DOID:4481	J30.9	D065631	607154	HP:0003193	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_down	hsa-mir-224	Allergic Rhinitis	24513959	respiratory system disease	DOID:4481	J30.9	D065631	607154	HP:0003193	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_down	hsa-mir-143	Allergic Rhinitis,Perennial	22185732			J30.89	D012221	607154		down-regulated
tissue_expression_down	hsa-mir-187	Allergic Rhinitis,Perennial	22185732			J30.89	D012221	607154		down-regulated
tissue_expression_down	hsa-mir-224	Allergic Rhinitis,Perennial	22185732			J30.89	D012221	607154		down-regulated
tissue_expression_down	hsa-mir-498	Allergic Rhinitis,Perennial	22185732			J30.89	D012221	607154		down-regulated
tissue_expression_down	hsa-mir-767	Allergic Rhinitis,Perennial	22185732			J30.89	D012221	607154		miR-767-5p: down-regulated
tissue_expression_down	hsa-mir-874	Allergic Rhinitis,Perennial	22185732			J30.89	D012221	607154		down-regulated
tissue_expression_down	hsa-mir-107	Alzheimer Disease	18234899	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	downregulated
tissue_expression_down	hsa-mir-128-1	Alzheimer Disease	21686130	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	miR-128a/b levels were significantly reduced in the temporal cortex and miR-128b in the frontal cortex in AD.
tissue_expression_down	hsa-mir-128-2	Alzheimer Disease	21686130	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	miR-128a/b levels were significantly reduced in the temporal cortex and miR-128b in the frontal cortex in AD.
tissue_expression_down	hsa-mir-181c	Alzheimer Disease	27423553	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	Taken together, these findings suggested that crmp2 is a target of miR-181c and that the abnormally low expression of miR-181c in the hippocampus of SAMP8 mice could lead to an increase of the crmp2 protein level in AD mice, which might potentially play a role in the pathogenesis of Alzheimer's disease.
tissue_expression_down	hsa-mir-29c	Alzheimer Disease	25973041	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	Present study indicated that miR-29c was downregulated in sporadic AD brains, and it targeted the 3' UTR of BACE1, reduced the BACE1 expression, and downregulated the APPβ accumulation in vitro.
tissue_expression_down	hsa-mir-1-1	Aortic Aneurysm, Thoracic	22010139	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		miRs -1, -21, -29a, -133a, and -486 showed decreased expression in Thoracic Aortic Aneurysm compared to normal aortic specimens.A significant relationship between miR expression levels (miRs -1, -21, -29a, and -133a) and aortic diameter was identified;
tissue_expression_down	hsa-mir-1-2	Aortic Aneurysm, Thoracic	22010139	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		miRs -1, -21, -29a, -133a, and -486 showed decreased expression in Thoracic Aortic Aneurysm compared to normal aortic specimens.A significant relationship between miR expression levels (miRs -1, -21, -29a, and -133a) and aortic diameter was identified;
tissue_expression_down	hsa-mir-133a-1	Aortic Aneurysm, Thoracic	22010139	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		miRs -1, -21, -29a, -133a, and -486 showed decreased expression in Thoracic Aortic Aneurysm compared to normal aortic specimens.A significant relationship between miR expression levels (miRs -1, -21, -29a, and -133a) and aortic diameter was identified;
tissue_expression_down	hsa-mir-133a-2	Aortic Aneurysm, Thoracic	22010139	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		miRs -1, -21, -29a, -133a, and -486 showed decreased expression in Thoracic Aortic Aneurysm compared to normal aortic specimens.A significant relationship between miR expression levels (miRs -1, -21, -29a, and -133a) and aortic diameter was identified;
tissue_expression_down	hsa-mir-21	Aortic Aneurysm, Thoracic	22010139	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		miRs -1, -21, -29a, -133a, and -486 showed decreased expression in Thoracic Aortic Aneurysm compared to normal aortic specimens.A significant relationship between miR expression levels (miRs -1, -21, -29a, and -133a) and aortic diameter was identified;
tissue_expression_down	hsa-mir-29a	Aortic Aneurysm, Thoracic	22010139	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		miRs -1, -21, -29a, -133a, and -486 showed decreased expression in Thoracic Aortic Aneurysm compared to normal aortic specimens.A significant relationship between miR expression levels (miRs -1, -21, -29a, and -133a) and aortic diameter was identified;
tissue_expression_down	hsa-mir-195	Aortic Insufficiency	20845893	cardiovascular system disease	DOID:57	I35.1	D001022		HP:0001659	miR-195:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI.
tissue_expression_down	hsa-mir-26a-1	Aortic Insufficiency	20845893	cardiovascular system disease	DOID:57	I35.1	D001022		HP:0001659	MiR-26a:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI.
tissue_expression_down	hsa-mir-26a-2	Aortic Insufficiency	20845893	cardiovascular system disease	DOID:57	I35.1	D001022		HP:0001659	MiR-26a:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI.
tissue_expression_down	hsa-mir-30b	Aortic Insufficiency	20845893	cardiovascular system disease	DOID:57	I35.1	D001022		HP:0001659	MiR-30b:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI.
tissue_expression_down	hsa-mir-195	Aortic Stenosis	20845893	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	miR-195:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI.
tissue_expression_down	hsa-mir-26a-1	Aortic Stenosis	20845893	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MiR-26a:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI.
tissue_expression_down	hsa-mir-26a-2	Aortic Stenosis	20845893	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MiR-26a:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI.
tissue_expression_down	hsa-mir-30b	Aortic Stenosis	20845893	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MiR-30b:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI.
tissue_expression_down	hsa-mir-142	Arteriosclerosis Obliterans	24743945	cardiovascular system disease	DOID:5160		D001162		HP:0002634	The results suggest that the expression of miR-142-3p is down-regulated in CD4+ T cells from patients with ASO. The down-regulation of miR-142-3p could increase the migration of CD4+ T cells to the vascular walls by regulation of actin cytoskeleton via its target genes, RAC1 and ROCK2.
tissue_expression_down	hsa-mir-122	Asthenozoospermia	21933900			R86.9	D053627			miR-122 was markedly decreased in azoospermia but increased in asthenozoospermia.
tissue_expression_down	hsa-mir-146b	Asthenozoospermia	21933900			R86.9	D053627			miR-146b was markedly decreased in azoospermia but increased in asthenozoospermia.
tissue_expression_down	hsa-mir-181a-2	Asthenozoospermia	21933900			R86.9	D053627			miR-181a was markedly decreased in azoospermia but increased in asthenozoospermia.
tissue_expression_down	hsa-mir-34c	Asthenozoospermia	21933900			R86.9	D053627			miR-34c-5p was markedly decreased in azoospermia but increased in asthenozoospermia.
tissue_expression_down	hsa-mir-374b	Asthenozoospermia	21933900			R86.9	D053627			miR-374b was markedly decreased in azoospermia but increased in asthenozoospermia.
tissue_expression_down	hsa-mir-509-1	Asthenozoospermia	21933900			R86.9	D053627			miR-509-5p was markedly decreased in azoospermia but increased in asthenozoospermia.
tissue_expression_down	hsa-mir-509-2	Asthenozoospermia	21933900			R86.9	D053627			miR-509-5p was markedly decreased in azoospermia but increased in asthenozoospermia.
tissue_expression_down	hsa-mir-509-3	Asthenozoospermia	21933900			R86.9	D053627			miR-509-5p was markedly decreased in azoospermia but increased in asthenozoospermia.
tissue_expression_down	hsa-mir-513a-1	Asthenozoospermia	21933900			R86.9	D053627			miR-513a-5p was markedly decreased in azoospermia but increased in asthenozoospermia.
tissue_expression_down	hsa-mir-513a-2	Asthenozoospermia	21933900			R86.9	D053627			miR-513a-5p was markedly decreased in azoospermia but increased in asthenozoospermia.
tissue_expression_down	hsa-let-7a	Asthma	25130484	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	We found significantly reduced expression of let-7a in bronchial biopsies from patients with severe asthma in comparison to patients with mild asthma as well as in comparison to the non-asthmatic controls.
tissue_expression_down	hsa-let-7e	Asthma	24513959	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_down	hsa-mir-125b	Asthma	27112664	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	miR-125b expression was  decreased in the sputum of the asthmatic patients especially in eosinophilic asthma.
tissue_expression_down	hsa-mir-126	Asthma	24513959	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_down	hsa-mir-146a	Asthma	21917308	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Measurement of the microRNA expression profile showed selective downregulation of miR-28-5p in CD8(+) T cells and reduction of miR-146a and miR-146b in both CD4(+) and CD8(+) T cells.
tissue_expression_down	hsa-mir-146b	Asthma	21917308	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Measurement of the microRNA expression profile showed selective downregulation of miR-28-5p in CD8(+) T cells and reduction of miR-146a and miR-146b in both CD4(+) and CD8(+) T cells.
tissue_expression_down	hsa-mir-155	Asthma	22558995	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	The decreased expression level of miR-155 is correlated to asthma disease severity.
tissue_expression_down	hsa-mir-155	Asthma	24513959	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_down	hsa-mir-18a	Asthma	24513959	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_down	hsa-mir-192	Asthma	23170939	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	MiR-192 was technically validated using real-time reverse transcription-quantitative polymerase chain reaction (RT-qPCR) showing that the level in asthmatics (pre-challenge) was significantly lower than HCs and that post-challenge was significantly lower than pre-challenge.
tissue_expression_down	hsa-mir-22	Asthma	27277384	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	miR-22-3p, miR鈥?13a-5p and miR-625-5p - were significantly downregulated in the asthma group compared with the control group
tissue_expression_down	hsa-mir-224	Asthma	24513959	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_down	hsa-mir-28	Asthma	21917308	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Measurement of the microRNA expression profile showed selective downregulation of miR-28-5p in CD8(+) T cells and reduction of miR-146a and miR-146b in both CD4(+) and CD8(+) T cells.
tissue_expression_down	hsa-mir-106a	Astrocytoma	20219352	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-106a:hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma
tissue_expression_down	hsa-mir-107	Astrocytoma	21978395	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-107, miR-124, miR-138, and miR-149 were downregulated significantly in grade I-IV astrocytomas, and overexpression of miR-124 and miR-149 inhibited glioblastoma cell proliferation and migration.
tissue_expression_down	hsa-mir-124	Astrocytoma	24718706	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	The low expression of these miRNAs may constitute a potential marker of astrocytomas that correlates with localization, possibly due to alterations in the maturation processes of these miRNAs that produced low mature forms in patients with recurrent pediatric astrocytomas.
tissue_expression_down	hsa-mir-124-1	Astrocytoma	21978395	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-107, miR-124, miR-138, and miR-149 were downregulated significantly in grade I-IV astrocytomas, and overexpression of miR-124 and miR-149 inhibited glioblastoma cell proliferation and migration.
tissue_expression_down	hsa-mir-124-2	Astrocytoma	21978395	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-107, miR-124, miR-138, and miR-149 were downregulated significantly in grade I-IV astrocytomas, and overexpression of miR-124 and miR-149 inhibited glioblastoma cell proliferation and migration.
tissue_expression_down	hsa-mir-124-3	Astrocytoma	21978395	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-107, miR-124, miR-138, and miR-149 were downregulated significantly in grade I-IV astrocytomas, and overexpression of miR-124 and miR-149 inhibited glioblastoma cell proliferation and migration.
tissue_expression_down	hsa-mir-128-1	Astrocytoma	24718706	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	The low expression of these miRNAs may constitute a potential marker of astrocytomas that correlates with localization, possibly due to alterations in the maturation processes of these miRNAs that produced low mature forms in patients with recurrent pediatric astrocytomas.
tissue_expression_down	hsa-mir-133a-1	Astrocytoma	22674182	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	Significantly decreased in grades II-IV patients.
tissue_expression_down	hsa-mir-133a-2	Astrocytoma	22674182	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	Significantly decreased in grades II-IV patients.
tissue_expression_down	hsa-mir-137	Astrocytoma	20219352	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-137:The down-regulation of hsa-miR-137 in astrocytomas was shown to be associated with advanced clinical stages of this disease
tissue_expression_down	hsa-mir-138-1	Astrocytoma	21978395	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-107, miR-124, miR-138, and miR-149 were downregulated significantly in grade I-IV astrocytomas, and overexpression of miR-124 and miR-149 inhibited glioblastoma cell proliferation and migration.
tissue_expression_down	hsa-mir-138-2	Astrocytoma	21978395	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-107, miR-124, miR-138, and miR-149 were downregulated significantly in grade I-IV astrocytomas, and overexpression of miR-124 and miR-149 inhibited glioblastoma cell proliferation and migration.
tissue_expression_down	hsa-mir-149	Astrocytoma	21978395	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-107, miR-124, miR-138, and miR-149 were downregulated significantly in grade I-IV astrocytomas, and overexpression of miR-124 and miR-149 inhibited glioblastoma cell proliferation and migration.
tissue_expression_down	hsa-mir-150	Astrocytoma	22674182	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-150*:Significantly decreased in grades II-IV patients.
tissue_expression_down	hsa-mir-15b	Astrocytoma	22674182	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-15b*: Significantly decreased in grades II-IV patients.
tissue_expression_down	hsa-mir-181b-1	Astrocytoma	19159078	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-181b: downregulation
tissue_expression_down	hsa-mir-181b-1	Astrocytoma	20219352	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-181b:hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma
tissue_expression_down	hsa-mir-181b-2	Astrocytoma	19159078	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-181b: downregulation
tissue_expression_down	hsa-mir-181b-2	Astrocytoma	20219352	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-181b:hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma
tissue_expression_down	hsa-mir-197	Astrocytoma	22674182	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	Significantly decreased in grades II-IV patients.
tissue_expression_down	hsa-mir-206	Astrocytoma	24390803	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	Decreased expression of microRNA-206 correlates with poor clinical outcome in patients with malignant astrocytomas.
tissue_expression_down	hsa-mir-218	Astrocytoma	20711171	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	Inhibition of two glioblastoma-upregulated miRNAs (miR-21 and miR-23a) and exogenous overexpression of two glioblastoma-downregulated miRNAs (miR-218 and miR-219-5p) resulted in reduced soft agar colony formation but showed varying effects on cell proliferation and chemosensitivity.
tissue_expression_down	hsa-mir-219	Astrocytoma	20711171	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	Inhibition of two glioblastoma-upregulated miRNAs (miR-21 and miR-23a) and exogenous overexpression of two glioblastoma-downregulated miRNAs (miR-218 and miR-219-5p) resulted in reduced soft agar colony formation but showed varying effects on cell proliferation and chemosensitivity.
tissue_expression_down	hsa-mir-221	Astrocytoma	24718706	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	The low expression of these miRNAs may constitute a potential marker of astrocytomas that correlates with localization, possibly due to alterations in the maturation processes of these miRNAs that produced low mature forms in patients with recurrent pediatric astrocytomas.
tissue_expression_down	hsa-mir-23a	Astrocytoma	22674182	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	Significantly decreased in grades II-IV patients.
tissue_expression_down	hsa-mir-497	Astrocytoma	22674182	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	Significantly decreased in grades II-IV patients.
tissue_expression_down	hsa-mir-548b	Astrocytoma	22674182	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-548b-5p: Significantly decreased in grades II-IV patients.
tissue_expression_down	hsa-mir-126	Atherosclerosis	26221595	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	our results suggest that miR-126 (i) is overexpressed by long-term LSS, (ii) has a role in up- and downregulation of genes involved in atherosclerosis, and (iii) affects SDC-4 expression.
tissue_expression_down	hsa-mir-126	Atherosclerosis	26886754	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	miR-126 expression was significantly down-regulated
tissue_expression_down	hsa-mir-126	Atherosclerosis	29642385	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Moreover, the expression level of miR-126 tended to be downregulated and that of miR-21 tended to be upregulated in ApoE KO mice exposed to the high dose of CS, albeit statistically insignificant
tissue_expression_down	hsa-mir-125b-1	Atopic Dermatitis	17622355	integumentary system disease	DOID:3310	L20	D003876	PS603165	HP:0001047	The level of this miRNA significantly (p<0.001 for both) decreased both in psoriasis and atopic eczema.
tissue_expression_down	hsa-mir-125b-2	Atopic Dermatitis	17622355	integumentary system disease	DOID:3310	L20	D003876	PS603165	HP:0001047	The level of this miRNA significantly (p<0.001 for both) decreased both in psoriasis and atopic eczema.
tissue_expression_down	hsa-mir-193a	Atrial Fibrillation	22944230	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated  in left atrial appendage (LAA) in patients with atrial fibrillation.
tissue_expression_down	hsa-mir-484	Autism Spectrum Disorder	27378146	disease of mental health	DOID:0060041	F84.0	D000067877	209850	HP:0000729	A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling.
tissue_expression_down	hsa-mir-16-1	Autoimmune Diseases [unspecific]	17351108				D001327	607836	HP:0002960	New Zealand black (NZB) mice (NZB) tissue sourcesof RNA showed a decrease in miR-16 in the spleen; however, theNZB kidney was not decreased in miR-16 expression compared withthe control strain expression. In addition, the NZB-derivedmalignant B-cell line, LNC, had an even greater decreased expressionof miR-16 compared with C57Bl6 spleen.
tissue_expression_down	hsa-mir-16-2	Autoimmune Diseases [unspecific]	17351108				D001327	607836	HP:0002960	New Zealand black (NZB) mice (NZB) tissue sourcesof RNA showed a decrease in miR-16 in the spleen; however, theNZB kidney was not decreased in miR-16 expression compared withthe control strain expression. In addition, the NZB-derivedmalignant B-cell line, LNC, had an even greater decreased expressionof miR-16 compared with C57Bl6 spleen.
tissue_expression_down	hsa-mir-181a	Autoimmune Diseases [unspecific]	27909056				D001327	607836	HP:0002960	Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.
tissue_expression_down	hsa-mir-30a	Autoimmune Diseases [unspecific]	27909056				D001327	607836	HP:0002960	Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.
tissue_expression_down	hsa-mir-141	Barrett Esophagus	21448356	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus.
tissue_expression_down	hsa-mir-200a	Barrett Esophagus	21448356	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus.
tissue_expression_down	hsa-mir-200b	Barrett Esophagus	21448356	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus.
tissue_expression_down	hsa-mir-200c	Barrett Esophagus	21448356	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus.
tissue_expression_down	hsa-mir-203	Barrett Esophagus	22094011	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	We demonstrated unequivocal statistically significant upregulation of two microRNAs (miR-192, 196a) and downregulation of miR-203 and positive miR-196a correlation with progression from intestinal metaplasia to adenocarcinoma compared to normal individuals.
tissue_expression_down	hsa-mir-203	Barrett Esophagus	27374102	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	miR-203 and miR-205 were lower in BE tissues
tissue_expression_down	hsa-mir-205	Barrett Esophagus	27374102	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	miR-203 and miR-205 were lower in BE tissues
tissue_expression_down	hsa-mir-429	Barrett Esophagus	21448356	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus.
tissue_expression_down	hsa-mir-155	Behcet Disease	22815348	cardiovascular system disease	DOID:13241	M35.2	D001528	109650		Decreased microRNA-155 Expression in Ocular Behcet's Disease but Not in Vogt Koyanagi Harada Syndrome.
tissue_expression_down	hsa-mir-155	Behcet Disease	28482290	cardiovascular system disease	DOID:13241	M35.2	D001528	109650		up regulation of miR-182 and miR-3591-3p; down regulation of miR-155, miR-638 and miR-4488 in the pathogenesis of the disease
tissue_expression_down	hsa-mir-4488	Behcet Disease	28482290	cardiovascular system disease	DOID:13241	M35.2	D001528	109650		up regulation of miR-182 and miR-3591-3p; down regulation of miR-155, miR-638 and miR-4488 in the pathogenesis of the disease
tissue_expression_down	hsa-mir-638	Behcet Disease	28482290	cardiovascular system disease	DOID:13241	M35.2	D001528	109650		up regulation of miR-182 and miR-3591-3p; down regulation of miR-155, miR-638 and miR-4488 in the pathogenesis of the disease
tissue_expression_down	hsa-let-7c	Bladder Neoplasms	25991007			C67	D001749	109800	HP:0009725	The present meta-analysis identified eight highly significant and consistently dysregulated miRNAs from 19 datasets. We also constructed an eight-miRNA signature which provided predictive and prognostic value that complements traditional clinicopathological risk factors.
tissue_expression_down	hsa-mir-1	Bladder Neoplasms	27350368			C67	D001749	109800	HP:0009725	down-regulated (miR-133a-3p, miR-1-3p, miR-99a-5p, miR-490-5p, and miR-133b)
tissue_expression_down	hsa-mir-1	Bladder Neoplasms	23169479			C67	D001749	109800	HP:0009725	three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)
tissue_expression_down	hsa-mir-100	Bladder Neoplasms	22393979			C67	D001749	109800	HP:0009725	Differential miRNA expression profiles in bladder urothelial carcinomas identified miR-100 down-regulation and miR-708 up-regulation among the most common alterations
tissue_expression_down	hsa-mir-124	Bladder Neoplasms	26310391			C67	D001749	109800	HP:0009725	Collectively, our study demonstrates that miR-124 can impair the proliferation or metastasis of human bladder cancer cells by down-regulation of UHRF1.
tissue_expression_down	hsa-mir-125	Bladder Neoplasms	25991007			C67	D001749	109800	HP:0009725	The present meta-analysis identified eight highly significant and consistently dysregulated miRNAs from 19 datasets. We also constructed an eight-miRNA signature which provided predictive and prognostic value that complements traditional clinicopathological risk factors.
tissue_expression_down	hsa-mir-125b	Bladder Neoplasms	19378336			C67	D001749	109800	HP:0009725	We identified a subset of 7 miRNAs (miR-145, miR-30a-3p, miR-133a, miR-133b, miR-195, miR-125b and miR-199a*) that were significantly downregulated in BCs.
tissue_expression_down	hsa-mir-125b	Bladder Neoplasms	23712207			C67	D001749	109800	HP:0009725	miRNAs downregulated in bladder cancer, such as miR-145, miR-143 and miR125b, are known to be tumour suppressors
tissue_expression_down	hsa-mir-1281	Bladder Neoplasms	23169479			C67	D001749	109800	HP:0009725	three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)
tissue_expression_down	hsa-mir-133a	Bladder Neoplasms	27350368			C67	D001749	109800	HP:0009725	five down-regulated (miR-133a-3p, miR-1-3p, miR-99a-5p, miR-490-5p, and miR-133b)
tissue_expression_down	hsa-mir-133a	Bladder Neoplasms	19378336			C67	D001749	109800	HP:0009725	We identified a subset of 7 miRNAs (miR-145, miR-30a-3p, miR-133a, miR-133b, miR-195, miR-125b and miR-199a*) that were significantly downregulated in BCs.
tissue_expression_down	hsa-mir-133a	Bladder Neoplasms	23169479			C67	D001749	109800	HP:0009725	three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)
tissue_expression_down	hsa-mir-133b	Bladder Neoplasms	27350368			C67	D001749	109800	HP:0009725	five down-regulated (miR-133a-3p, miR-1-3p, miR-99a-5p, miR-490-5p, and miR-133b)
tissue_expression_down	hsa-mir-133b	Bladder Neoplasms	19378336			C67	D001749	109800	HP:0009725	We identified a subset of 7 miRNAs (miR-145, miR-30a-3p, miR-133a, miR-133b, miR-195, miR-125b and miR-199a*) that were significantly downregulated in BCs.
tissue_expression_down	hsa-mir-133b	Bladder Neoplasms	23169479			C67	D001749	109800	HP:0009725	three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)
tissue_expression_down	hsa-mir-143	Bladder Neoplasms	23169479			C67	D001749	109800	HP:0009725	three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)
tissue_expression_down	hsa-mir-143	Bladder Neoplasms	23712207			C67	D001749	109800	HP:0009725	miRNAs downregulated in bladder cancer, such as miR-145, miR-143 and miR125b, are known to be tumour suppressors
tissue_expression_down	hsa-mir-145	Bladder Neoplasms	25991007			C67	D001749	109800	HP:0009725	The present meta-analysis identified eight highly significant and consistently dysregulated miRNAs from 19 datasets. We also constructed an eight-miRNA signature which provided predictive and prognostic value that complements traditional clinicopathological risk factors.
tissue_expression_down	hsa-mir-145	Bladder Neoplasms	19915607			C67	D001749	109800	HP:0009725	Our data indicate that reduction in miR-145 expression may provide bladder cancer cells with a selective advantage by inhibition of cell death otherwise triggered in malignant cells.
tissue_expression_down	hsa-mir-145	Bladder Neoplasms	19378336			C67	D001749	109800	HP:0009725	We identified a subset of 7 miRNAs (miR-145, miR-30a-3p, miR-133a, miR-133b, miR-195, miR-125b and miR-199a*) that were significantly downregulated in BCs.
tissue_expression_down	hsa-mir-145	Bladder Neoplasms	23169479			C67	D001749	109800	HP:0009725	three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)
tissue_expression_down	hsa-mir-145	Bladder Neoplasms	23712207			C67	D001749	109800	HP:0009725	miRNAs downregulated in bladder cancer, such as miR-145, miR-143 and miR125b, are known to be tumour suppressors
tissue_expression_down	hsa-mir-148a	Bladder Neoplasms	26700670			C67	D001749	109800	HP:0009725	miR-148a expression was decreased in bladder cancer specimens and reduced miR-148a expression was associated with poorer survival time
tissue_expression_down	hsa-mir-195	Bladder Neoplasms	19378336			C67	D001749	109800	HP:0009725	We identified a subset of 7 miRNAs (miR-145, miR-30a-3p, miR-133a, miR-133b, miR-195, miR-125b and miR-199a*) that were significantly downregulated in BCs.
tissue_expression_down	hsa-mir-199a	Bladder Neoplasms	25991007			C67	D001749	109800	HP:0009725	The present meta-analysis identified eight highly significant and consistently dysregulated miRNAs from 19 datasets. We also constructed an eight-miRNA signature which provided predictive and prognostic value that complements traditional clinicopathological risk factors.
tissue_expression_down	hsa-mir-199a	Bladder Neoplasms	19378336			C67	D001749	109800	HP:0009725	We identified a subset of 7 miRNAs (miR-145, miR-30a-3p, miR-133a, miR-133b, miR-195, miR-125b and miR-199a*) that were significantly downregulated in BCs.
tissue_expression_down	hsa-mir-199a	Bladder Neoplasms	23169479			C67	D001749	109800	HP:0009725	three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)
tissue_expression_down	hsa-mir-199b	Bladder Neoplasms	23169479			C67	D001749	109800	HP:0009725	three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)
tissue_expression_down	hsa-mir-200c	Bladder Neoplasms	25367080			C67	D001749	109800	HP:0009725	miR-200c inhibits invasion, migration and proliferation of bladder cancer cells through down-regulation of BMI-1 and E2F3.
tissue_expression_down	hsa-mir-204	Bladder Neoplasms	23169479			C67	D001749	109800	HP:0009725	three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)
tissue_expression_down	hsa-mir-30a	Bladder Neoplasms	19378336			C67	D001749	109800	HP:0009725	We identified a subset of 7 miRNAs (miR-145, miR-30a-3p, miR-133a, miR-133b, miR-195, miR-125b and miR-199a*) that were significantly downregulated in BCs.
tissue_expression_down	hsa-mir-490	Bladder Neoplasms	27350368			C67	D001749	109800	HP:0009725	five down-regulated (miR-133a-3p, miR-1-3p, miR-99a-5p, miR-490-5p, and miR-133b)
tissue_expression_down	hsa-mir-921	Bladder Neoplasms	23169479			C67	D001749	109800	HP:0009725	three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)
tissue_expression_down	hsa-mir-99a	Bladder Neoplasms	24957100			C67	D001749	109800	HP:0009725	Our data indicated that miR-99a might act as a tumor suppressor in bladder cancer and was significantly down-regulated in development of bladder cancer.
tissue_expression_down	hsa-mir-99a	Bladder Neoplasms	25991007			C67	D001749	109800	HP:0009725	The present meta-analysis identified eight highly significant and consistently dysregulated miRNAs from 19 datasets. We also constructed an eight-miRNA signature which provided predictive and prognostic value that complements traditional clinicopathological risk factors.
tissue_expression_down	hsa-mir-99a	Bladder Neoplasms	27350368			C67	D001749	109800	HP:0009725	five down-regulated (miR-133a-3p, miR-1-3p, miR-99a-5p, miR-490-5p, and miR-133b)
tissue_expression_down	hsa-let-7	Breast Neoplasms	27082076	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Significant alterations of expression included upregulation of miR-21-5p and the miR-200 family and downregulation of let-7 family members in DCIS samples.
tissue_expression_down	hsa-let-7a-1	Breast Neoplasms	22403704	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT
tissue_expression_down	hsa-let-7a-2	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let-7a-2, 7a-3, 7d, 7f-2 downregulated in breast cancer
tissue_expression_down	hsa-let-7a-2	Breast Neoplasms	22403704	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT
tissue_expression_down	hsa-let-7a-3	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let-7a-2, 7a-3, 7d, 7f-2 downregulated in breast cancer
tissue_expression_down	hsa-let-7a-3	Breast Neoplasms	22403704	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT
tissue_expression_down	hsa-let-7b	Breast Neoplasms	22403704	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT
tissue_expression_down	hsa-let-7c	Breast Neoplasms	22403704	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT
tissue_expression_down	hsa-let-7c	Breast Neoplasms	25122196	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Let-7c were among the identified downregulated epithelial  miRNAs and its functions were delineated in unique CCH derived cells and breast cancer cell line MCF-7 suggesting anti-proliferative traits potentially due to effects on Myb and ER伪.
tissue_expression_down	hsa-let-7d	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let-7a-2, 7a-3, 7d, 7f-2 downregulated in breast cancer
tissue_expression_down	hsa-let-7d	Breast Neoplasms	22315424	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let-7d, miR-210, and -221 were down-regulated in the in situ and up-regulated in the invasive transition, thus featuring an expression reversal along the cancer progression path.
tissue_expression_down	hsa-let-7d	Breast Neoplasms	22403704	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT
tissue_expression_down	hsa-let-7e	Breast Neoplasms	22403704	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT
tissue_expression_down	hsa-let-7f-1	Breast Neoplasms	22403704	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT
tissue_expression_down	hsa-let-7f-2	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let-7a-2, 7a-3, 7d, 7f-2 downregulated in breast cancer
tissue_expression_down	hsa-let-7f-2	Breast Neoplasms	22403704	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT
tissue_expression_down	hsa-let-7f-2	Breast Neoplasms	22407818	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Aromatase inhibitor treatment of breast cancer cells increases the expression of let-7f, a microRNA targeting CYP19A1.
tissue_expression_down	hsa-let-7g	Breast Neoplasms	21868760	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Treatment with estrogen or EGF specifically reduced the expression of mature let-7g through activation of p44/42 MAPK and subsequently stimulated expression of GAB2 and FN1, which in turn promoted tumor invasion. We thus identify let-7g as a unique member of the let-7 miRNA family which can serve as a prognostic biomarker in breast cancer and also  propose a paradigm utilized by specific signaling molecules via let-7g to cooperatively promote breast cancer invasion and metastasis.
tissue_expression_down	hsa-let-7g	Breast Neoplasms	22964023	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)
tissue_expression_down	hsa-mir-101	Breast Neoplasms	22964023	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)
tissue_expression_down	hsa-mir-107	Breast Neoplasms	27813254	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MicroRNA-107 is downregulated and having tumor suppressive effect in breast cancer by negatively regulating brain-derived neurotrophic factor.
tissue_expression_down	hsa-mir-107	Breast Neoplasms	28128741	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-15/107/182-mediated downregulation of BRCA1 interrupt DNA repair and may change the course of BC therapy
tissue_expression_down	hsa-mir-10b	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	mir-10b downregulated in breast cancer (Iorio et al., 2005);
tissue_expression_down	hsa-mir-10b	Breast Neoplasms	21953071	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium.
tissue_expression_down	hsa-mir-10b	Breast Neoplasms	23125021	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-10b*, a master inhibitor of the cell cycle, is down-regulated in human breast tumours
tissue_expression_down	hsa-mir-124	Breast Neoplasms	25731732	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiR-124 inhibits cell proliferation in breast cancer through downregulation of CDK4.
tissue_expression_down	hsa-mir-124	Breast Neoplasms	25924779	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	These findings proved that the decreased expression of miR-124 might be associated with tumor progression and poor prognosis in patients with breast cancer.
tissue_expression_down	hsa-mir-124	Breast Neoplasms	26415857	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Our data suggested that decreased expression of miR-124 has prognostic value in breast cancer and may serve as a prognostic marker for breast cancer, and also downregulation of miR-124 was inversely associated with the lymph node metastasis in breast cancer.
tissue_expression_down	hsa-mir-125a	Breast Neoplasms	25531695	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	HDACi influence tumorigenesis and apoptosis via downregulation of miR-125a-5p expression. This study provides clinical implications in cancer chemotherapy using HDACi.
tissue_expression_down	hsa-mir-125a	Breast Neoplasms	26782438	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Taken together, these findings suggest that miR-125a-5p may play an important role in BC progression in an age-dependent manner, and that the down-regulation of miR-125a-5p and miR-125b may serve as independent predictors for breast cancer.
tissue_expression_down	hsa-mir-125a	Breast Neoplasms	16103053	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	downregulation
tissue_expression_down	hsa-mir-125a	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	mir-125a, b1, b2 downregulated in breast cancer (Iorio et al., 2005);
tissue_expression_down	hsa-mir-125b	Breast Neoplasms	19290006	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Compared with normal breast samples, a panel of miRs was consistently dysregulated in breast cancer, including earlier-reported breast cancer-related miRs, such as upregulated miR-21, miR-155, miR-191, and miR-196a, and downregulated miR-125b and miR-221.
tissue_expression_down	hsa-mir-125b-1	Breast Neoplasms	16103053	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	downregulation
tissue_expression_down	hsa-mir-125b-1	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	mir-125a, b1, b2 downregulated in breast cancer (Iorio et al., 2005);
tissue_expression_down	hsa-mir-125b-1	Breast Neoplasms	22898264	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Upregulation of miR-21 and miR-191 and downregulation of miR-125b, was found in breast cancer tissue.
tissue_expression_down	hsa-mir-125b-2	Breast Neoplasms	16103053	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	downregulation
tissue_expression_down	hsa-mir-125b-2	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	mir-125a, b1, b2 downregulated in breast cancer (Iorio et al., 2005);
tissue_expression_down	hsa-mir-125b-2	Breast Neoplasms	22898264	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Upregulation of miR-21 and miR-191 and downregulation of miR-125b, was found in breast cancer tissue.
tissue_expression_down	hsa-mir-126	Breast Neoplasms	22524830	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	down regulation in mir-17p, mir-126, mir-335, mir-30b
tissue_expression_down	hsa-mir-126	Breast Neoplasms	20801493	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	A high correlation of miRNA expression level was found between breast tumor tissues and sera. MiR-21, miR-106a and miR-155 were significantly over-expressed in the tumor specimens compared with those in normal controls (P < 0.05), whereas miR-126, miR-199a and miR-335 were significantly under-expressed (P < 0.05).
tissue_expression_down	hsa-mir-129-1	Breast Neoplasms	22907300	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-129 is found to significantly inhibit the migration of MDA-MB-231 both in Transwell migration assay and wound healing assay. Furthermore, miR-129 also shows great suppressive ability to cell mobility and migration in another two breast cancer cell lines BT549 and MDA-MB-435s. Most importantly, miR-129 is down-regulated both in breast cancer tissues compared with the paired adjacent normal breast tissues, and in breast cancer cell lines compared with normal breast epithelial cell MCF10A (P < 0.05).
tissue_expression_down	hsa-mir-129-2	Breast Neoplasms	22907300	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-129 is found to significantly inhibit the migration of MDA-MB-231 both in Transwell migration assay and wound healing assay. Furthermore, miR-129 also shows great suppressive ability to cell mobility and migration in another two breast cancer cell lines BT549 and MDA-MB-435s. Most importantly, miR-129 is down-regulated both in breast cancer tissues compared with the paired adjacent normal breast tissues, and in breast cancer cell lines compared with normal breast epithelial cell MCF10A (P < 0.05).
tissue_expression_down	hsa-mir-132	Breast Neoplasms	23399321	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MicroRNA-132 is frequently down-regulated in ductal carcinoma in situ (DCIS) of breast and acts as a tumor suppressor by inhibiting cell proliferation
tissue_expression_down	hsa-mir-133b	Breast Neoplasms	19946373	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	downregulated
tissue_expression_down	hsa-mir-139	Breast Neoplasms	21953071	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium.
tissue_expression_down	hsa-mir-140	Breast Neoplasms	21953071	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium.
tissue_expression_down	hsa-mir-141	Breast Neoplasms	25241899	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and Stat5a.
tissue_expression_down	hsa-mir-141	Breast Neoplasms	22964023	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)
tissue_expression_down	hsa-mir-143	Breast Neoplasms	27236032	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The expression levels of miR-143, miR-663a and miR-668 were significantly reduced in FHIT downregulated tumors.
tissue_expression_down	hsa-mir-145	Breast Neoplasms	16103053	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	downregulation
tissue_expression_down	hsa-mir-145	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	mir-145 downregulated in breast cancer (Iorio et al., 2005) and lung cancer and deleted in prostate cancer (Yanaihara et al., 2006);
tissue_expression_down	hsa-mir-145	Breast Neoplasms	20331864	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	down-regulated in male breast cancer
tissue_expression_down	hsa-mir-145	Breast Neoplasms	27396353	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Loss of miR-145 expression is related to the development of breast cancer complicated by T2DM, and low miR-145 expression might be an adverse prognostic factor in patients with this disease.
tissue_expression_down	hsa-mir-146a	Breast Neoplasms	25596948	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	quercetin exhibited excellent effect on inhibiting cell proliferation in human breast cancer cells, which was performed by up-regulating miR-146a expression, then via inducing apoptosis through caspase-3 activation and mitochondrial-dependent pathways, and inhibiting invasion through down-regulating the expression of EGFR.
tissue_expression_down	hsa-mir-146a	Breast Neoplasms	26406414	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Down-regulations of miR-146a and miR-146b expression in breast tissues were related to development and deterioration of breast cancer. miR-146a and miR-146b might act as potential biomarkers for young women with breast cancer.
tissue_expression_down	hsa-mir-146a	Breast Neoplasms	26458573	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	In conclusion, catalpol suppresses proliferation and facilitates apoptosis of MCF-7 breast cancer cells through upregulating miR-146a and downregulating MMP-16 expression.
tissue_expression_down	hsa-mir-146b	Breast Neoplasms	26406414	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Down-regulations of miR-146a and miR-146b expression in breast tissues were related to development and deterioration of breast cancer. miR-146a and miR-146b might act as potential biomarkers for young women with breast cancer.
tissue_expression_down	hsa-mir-15	Breast Neoplasms	28128741	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-15/107/182-mediated downregulation of BRCA1 interrupt DNA repair and may change the course of BC therapy
tissue_expression_down	hsa-mir-16-1	Breast Neoplasms	22583478	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development.
tissue_expression_down	hsa-mir-17	Breast Neoplasms	22524830	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	down regulation in mir-17p, mir-126, mir-335, mir-30b
tissue_expression_down	hsa-mir-182	Breast Neoplasms	19665978	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	downregulated in human BCSCs
tissue_expression_down	hsa-mir-182	Breast Neoplasms	28128741	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-15/107/182-mediated downregulation of BRCA1 interrupt DNA repair and may change the course of BC therapy
tissue_expression_down	hsa-mir-183	Breast Neoplasms	19665978	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	downregulated in human BCSCs
tissue_expression_down	hsa-mir-191	Breast Neoplasms	22898264	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Upregulation of miR-21 and miR-191 and downregulation of miR-125b, was found in breast cancer tissue.
tissue_expression_down	hsa-mir-1915	Breast Neoplasms	22403704	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT
tissue_expression_down	hsa-mir-195	Breast Neoplasms	22800791	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The levels of miR-195 in the breast cancer with histological high grade, tumor size of T3-4, lymph nodal involvement or vessel invasion were significantly down-regulated, compared with those of patients with histological low grade (Z = -2.271, P = 0.023), tumor size of T1-2 (Z = -2.687, P = 0.007), no lymph node metastasis (Z = -1.967, P = 0.049) and vessel invasion (Z = -2.432, P = 0.015).
tissue_expression_down	hsa-mir-199a	Breast Neoplasms	20801493	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	A high correlation of miRNA expression level was found between breast tumor tissues and sera. MiR-21, miR-106a and miR-155 were significantly over-expressed in the tumor specimens compared with those in normal controls (P < 0.05), whereas miR-126, miR-199a and miR-335 were significantly under-expressed (P < 0.05).
tissue_expression_down	hsa-mir-199b	Breast Neoplasms	27788476	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Down-regulation of miR-199b-5p is correlated with poor prognosis for breast cancer patients.
tissue_expression_down	hsa-mir-19a	Breast Neoplasms	23831570	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene.
tissue_expression_down	hsa-mir-19a	Breast Neoplasms	26416600	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	the expression levels of miR-19a-3p, miR-19b-3p and miR-130a-3p were much lower in the MCF-7 cells
tissue_expression_down	hsa-mir-200	Breast Neoplasms	27082076	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNAs  included in the invasive signatures include downregulation of miR-139-5p in aggressive subtypes and upregulation of miR-29c-5p expression in the luminal subtypes.
tissue_expression_down	hsa-mir-200a	Breast Neoplasms	19665978	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	downregulated in human BCSCs
tissue_expression_down	hsa-mir-200a	Breast Neoplasms	23626803	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Reduced expression of miR-200 family members contributes to antiestrogen resistance in LY2 human breast cancer cells.
tissue_expression_down	hsa-mir-200b	Breast Neoplasms	22964023	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)
tissue_expression_down	hsa-mir-200b	Breast Neoplasms	23626803	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Reduced expression of miR-200 family members contributes to antiestrogen resistance in LY2 human breast cancer cells.
tissue_expression_down	hsa-mir-200c	Breast Neoplasms	22101791	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Down-regulation of microRNA-200c is associated with drug resistance in human breast cancer.Down-regulated miR-200c was observed in non-responders as compared to responders. In addition, miR-200c expression was observed to be down-regulated over 800-fold in human breast cancer cells resistant to doxorubicin MCF-7/ADR as compared to the parental MCF-7 cells. Up-regulation of miR-200c with transfection of miR-200c mimics in breast cancer cells could enhance the chemosensitivity to epirubicin and reduce expression of multidrug resistance 1 mRNA and P-glycoprotein. Moreover, our study demonstrated that restoration of miR-200c in MCF-7/ADR cells could increase intracellular doxorubicin accumulation determined by flow cytometry.
tissue_expression_down	hsa-mir-200c	Breast Neoplasms	22964023	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)
tissue_expression_down	hsa-mir-200c	Breast Neoplasms	23626803	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Reduced expression of miR-200 family members contributes to antiestrogen resistance in LY2 human breast cancer cells.
tissue_expression_down	hsa-mir-203a	Breast Neoplasms	27431784	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Moreover, we found a significant downregulation of miR-203a with increased stage in invasive lobular carcinomas, suggesting that miR-203a could represent a potential marker to discriminate stages in invasive lobular carcinomas.
tissue_expression_down	hsa-mir-205	Breast Neoplasms	19238171	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-205: Suppress cell growth and invasion by target ErbB3 and VEGF-A
tissue_expression_down	hsa-mir-205	Breast Neoplasms	22964023	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)
tissue_expression_down	hsa-mir-206	Breast Neoplasms	23466356	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-206 is down-regulated in breast cancer and inhibits cell proliferation through the up-regulation of cyclinD2
tissue_expression_down	hsa-mir-21	Breast Neoplasms	26555418	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The established MCF-7/PR and SKBR-3/PR breast cancer cells show typical multidrug resistance characteristics, which can be used as the model for drug resistance study. Down-regulated miR-21 expression in MCF-7/PR and SKBR-3/PR breast cancer cells can enhance cell sensitivity to paclitaxel.
tissue_expression_down	hsa-mir-21	Breast Neoplasms	22898264	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Upregulation of miR-21 and miR-191 and downregulation of miR-125b, was found in breast cancer tissue.
tissue_expression_down	hsa-mir-210	Breast Neoplasms	22315424	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let-7d, miR-210, and -221 were down-regulated in the in situ and up-regulated in the invasive transition, thus featuring an expression reversal along the cancer progression path.
tissue_expression_down	hsa-mir-214	Breast Neoplasms	21828058	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Decreased MicroRNA-214 Levels In Breast Cancer Cells Coincides with Increased Cell Proliferation, Invasion, and Accumulation of the Polycomb Ezh2 Methyltransferase.
tissue_expression_down	hsa-mir-221	Breast Neoplasms	22315424	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let-7d, miR-210, and -221 were down-regulated in the in situ and up-regulated in the invasive transition, thus featuring an expression reversal along the cancer progression path.
tissue_expression_down	hsa-mir-221	Breast Neoplasms	19290006	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Compared with normal breast samples, a panel of miRs was consistently dysregulated in breast cancer, including earlier-reported breast cancer-related miRs, such as upregulated miR-21, miR-155, miR-191, and miR-196a, and downregulated miR-125b and miR-221.
tissue_expression_down	hsa-mir-224	Breast Neoplasms	21953071	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium.
tissue_expression_down	hsa-mir-26b	Breast Neoplasms	23939832	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion.
tissue_expression_down	hsa-mir-26b	Breast Neoplasms	22964023	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)
tissue_expression_down	hsa-mir-27b	Breast Neoplasms	22403704	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT
tissue_expression_down	hsa-mir-29b	Breast Neoplasms	28465475	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Down-regulation of miR-29b in carcinoma associated fibroblasts promotes cell growth and metastasis of breast cancer.
tissue_expression_down	hsa-mir-302b	Breast Neoplasms	26644266	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miR-302S family including miR-302a, miR-302b, miR-302c, and miR-302d was significantly down-regulated in BCRP-overexpressing MCF-7/MX cells.
tissue_expression_down	hsa-mir-302d	Breast Neoplasms	26644266	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miR-302S family including miR-302a, miR-302b, miR-302c, and miR-302d was significantly down-regulated in BCRP-overexpressing MCF-7/MX cells.
tissue_expression_down	hsa-mir-30b	Breast Neoplasms	22524830	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	down regulation in mir-17p, mir-126, mir-335, mir-30b
tissue_expression_down	hsa-mir-30c-2	Breast Neoplasms	25732226	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MicroRNA-30c-2-3p negatively regulates NF-κB signaling and cell cycle progression through downregulation of TRADD and CCNE1 in breast cancer.
tissue_expression_down	hsa-mir-335	Breast Neoplasms	22524830	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	down regulation in mir-17p, mir-126, mir-335, mir-30b
tissue_expression_down	hsa-mir-335	Breast Neoplasms	20801493	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	A high correlation of miRNA expression level was found between breast tumor tissues and sera. MiR-21, miR-106a and miR-155 were significantly over-expressed in the tumor specimens compared with those in normal controls (P < 0.05), whereas miR-126, miR-199a and miR-335 were significantly under-expressed (P < 0.05).
tissue_expression_down	hsa-mir-342	Breast Neoplasms	21172025	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Downregulation of miR-342 is Associated with Tamoxifen Resistant Breast Tumors.
tissue_expression_down	hsa-mir-342	Breast Neoplasms	22964023	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)
tissue_expression_down	hsa-mir-34a	Breast Neoplasms	25771001	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	we provide direct evidence that TQ-Nps showed more efficiency in killing cancer cells as well as proved to be less toxic to normal cells at a significantly lower dose than TQ.NPs mediated miR-34a up-regulation directly down-regulated Rac1 expression followed by actin depolymerisation thereby disrupting the actin cytoskeleton which leads to significant reduction in the lamellipodia and filopodia formation on cell surfaces thus retarding cell migration.
tissue_expression_down	hsa-mir-34a	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	mir-34 downregulated in breast cancer (Iorio et al., 2005)
tissue_expression_down	hsa-mir-34a	Breast Neoplasms	22623155	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1.
tissue_expression_down	hsa-mir-34a	Breast Neoplasms	26553365	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Here we show that SNAI2 down-regulates miR34a expression in hypoxic MCF7 cell-derived mammospheres.
tissue_expression_down	hsa-mir-34b	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	mir-34 downregulated in breast cancer (Iorio et al., 2005)
tissue_expression_down	hsa-mir-34c	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	mir-34 downregulated in breast cancer (Iorio et al., 2005)
tissue_expression_down	hsa-mir-365a	Breast Neoplasms	21953071	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium.
tissue_expression_down	hsa-mir-365b	Breast Neoplasms	21953071	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium.
tissue_expression_down	hsa-mir-429	Breast Neoplasms	19665978	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	downregulated in human BCSCs
tissue_expression_down	hsa-mir-450a-1	Breast Neoplasms	21953071	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium.
tissue_expression_down	hsa-mir-450a-2	Breast Neoplasms	21953071	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium.
tissue_expression_down	hsa-mir-450b	Breast Neoplasms	21953071	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium.
tissue_expression_down	hsa-mir-451a	Breast Neoplasms	21666713	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Tamoxifen downregulation of miR-451 increases 14-3-3 and promotes breast cancer cell survival and endocrine resistance.
tissue_expression_down	hsa-mir-486	Breast Neoplasms	19946373	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-486-5p: downregulated
tissue_expression_down	hsa-mir-497	Breast Neoplasms	24143964	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	downregulation of miR-497 was correlated with BC progression, and miR-497 might be a potential molecular biomarker for predicting the prognosis of patients.
tissue_expression_down	hsa-mir-497	Breast Neoplasms	20331864	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	down-regulated in male breast cancer
tissue_expression_down	hsa-mir-519d	Breast Neoplasms	26238950	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-519d-mediated downregulation of STAT3 suppresses breast cancer progression.
tissue_expression_down	hsa-mir-661	Breast Neoplasms	24141721	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-661 downregulates both Mdm2 and Mdm4 to activate p53.
tissue_expression_down	hsa-mir-663a	Breast Neoplasms	27236032	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The expression levels of miR-143, miR-663a and miR-668 were significantly reduced in FHIT downregulated tumors.
tissue_expression_down	hsa-mir-668	Breast Neoplasms	27236032	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The expression levels of miR-143, miR-663a and miR-668 were significantly reduced in FHIT downregulated tumors.
tissue_expression_down	hsa-mir-802	Breast Neoplasms	26080894	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MicroRNA-802 suppresses breast cancer proliferation through downregulation of FoxM1.
tissue_expression_down	hsa-mir-922	Breast Neoplasms	27236032	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The expression levels of  the miRNAs and FHIT were downregulated in breast cancer tissue.
tissue_expression_down	hsa-mir-96	Breast Neoplasms	19665978	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	downregulated in human BCSCs
tissue_expression_down	hsa-mir-16	Bronchiolitis Obliterans Syndrome	25941328	respiratory system disease	DOID:2799	J42	D001989		HP:0011946	The expression of miR-16 and miR-195 was significantly decreased  in lungs of OAD mice
tissue_expression_down	hsa-mir-203	Burns	22360957			M61.30	D002056			miR-203 was down-regulated in denatured dermis compared with those in normal skin.
tissue_expression_down	hsa-mir-222	Carcinoma, Adenoid Cystic	28277192	disease of cellular proliferation	DOID:0080202		D003528			Downregulation of miR-222 Induces Apoptosis and Cellular Migration in Adenoid Cystic Carcinoma Cells.
tissue_expression_down	hsa-mir-106b	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-106b: down-regulated
tissue_expression_down	hsa-mir-125b-1	Carcinoma, Adrenocortical	21472710	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miRs -100, -125b, and -195 were significantly down-regulated, whereas miR-483-5p was significantly up-regulated in malignant as compared with benign tumors.
tissue_expression_down	hsa-mir-125b-2	Carcinoma, Adrenocortical	21472710	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miRs -100, -125b, and -195 were significantly down-regulated, whereas miR-483-5p was significantly up-regulated in malignant as compared with benign tumors.
tissue_expression_down	hsa-mir-139	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-139: down-regulated
tissue_expression_down	hsa-mir-148a	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-148a: down-regulated
tissue_expression_down	hsa-mir-195	Carcinoma, Adrenocortical	21472710	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miRs -100, -125b, and -195 were significantly down-regulated, whereas miR-483-5p was significantly up-regulated in malignant as compared with benign tumors.
tissue_expression_down	hsa-mir-195	Carcinoma, Adrenocortical	21859927	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	Among others, miR-483-3p, miR-483-5p, miR-210, and miR-21 were found overexpressed,while miR-195, miR-497, and miR-1974 were underexpressed in ACC. 
tissue_expression_down	hsa-mir-196a-1	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-196a: down-regulated
tissue_expression_down	hsa-mir-196a-2	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-196a: down-regulated
tissue_expression_down	hsa-mir-1974	Carcinoma, Adrenocortical	21859927	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	Among others, miR-483-3p, miR-483-5p, miR-210, and miR-21 were found overexpressed,while miR-195, miR-497, and miR-1974 were underexpressed in ACC. 
tissue_expression_down	hsa-mir-210	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-210: down-regulated
tissue_expression_down	hsa-mir-301a	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-301: down-regulated
tissue_expression_down	hsa-mir-301b	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-301: down-regulated
tissue_expression_down	hsa-mir-376a-1	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-376: down-regulated
tissue_expression_down	hsa-mir-376a-2	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-376: down-regulated
tissue_expression_down	hsa-mir-376b	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-376: down-regulated
tissue_expression_down	hsa-mir-376c	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-376: down-regulated
tissue_expression_down	hsa-mir-424	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-424: down-regulated
tissue_expression_down	hsa-mir-484	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-484: down-regulated
tissue_expression_down	hsa-mir-491	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-491: down-regulated
tissue_expression_down	hsa-mir-497	Carcinoma, Adrenocortical	21859927	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	Among others, miR-483-3p, miR-483-5p, miR-210, and miR-21 were found overexpressed,while miR-195, miR-497, and miR-1974 were underexpressed in ACC. 
tissue_expression_down	hsa-mir-139	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	miR-139-5p is downregulated in the tumor center
tissue_expression_down	hsa-mir-140	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	miR-140-3p is downregulated in the tumor center
tissue_expression_down	hsa-mir-145	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	downregulated in the tumor center
tissue_expression_down	hsa-mir-183	Carcinoma, Basal Cell	22384406	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	The expression level of miR-183 was consistently lower in infiltrative than nodular tumors and could be one element underlying the difference in invasiveness.
tissue_expression_down	hsa-mir-2861	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	downregulated in the tumor center
tissue_expression_down	hsa-mir-29c	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	miR-29c and miR-29c* are downregulated in the tumor center
tissue_expression_down	hsa-mir-3196	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	downregulated in the tumor center
tissue_expression_down	hsa-mir-378a	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	downregulated in the tumor center
tissue_expression_down	hsa-mir-378b	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	downregulated in the tumor center
tissue_expression_down	hsa-mir-378c	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	downregulated in the tumor center
tissue_expression_down	hsa-mir-378d-1	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	downregulated in the tumor center
tissue_expression_down	hsa-mir-378d-2	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	downregulated in the tumor center
tissue_expression_down	hsa-mir-378e	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	downregulated in the tumor center
tissue_expression_down	hsa-mir-378f	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	downregulated in the tumor center
tissue_expression_down	hsa-mir-378g	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	downregulated in the tumor center
tissue_expression_down	hsa-mir-378h	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	downregulated in the tumor center
tissue_expression_down	hsa-mir-378i	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	downregulated in the tumor center
tissue_expression_down	hsa-mir-572	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	downregulated in the tumor center
tissue_expression_down	hsa-mir-638	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	downregulated in the tumor center
tissue_expression_down	hsa-let-7i	Carcinoma, Bladder	23946872	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	Within this group, let-7b and let-7i exhibited decreased expression, while miR-1290 and miR-138 displayed increased expression levels in gemcitabine-resistant cells.
tissue_expression_down	hsa-mir-101	Carcinoma, Bladder	24834983	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	Our results suggest that the expression of miR-101 is down-regulated in BTCC, which consequently favored tumor progression. MiR-101 may play an important role as a diagnostic and prognostic marker in BTCC.
tissue_expression_down	hsa-mir-205	Carcinoma, Breast	27278159			D05	D001943	114480	HP:0003002	miR-205 was a miR specific to BLBC which functioned as tumor suppressor gene through directly targeting and negatively regulating proto-oncogene KLF12.
tissue_expression_down	hsa-mir-409	Carcinoma, Breast	27735035			D05	D001943	114480	HP:0003002	Low expression of miR-409-3p is a prognostic marker for breast cancer.
tissue_expression_down	hsa-mir-136	Carcinoma, Breast, Triple Negative	27108696				D064726			miR-136 was downregulated in TNBC and negative correlated with the WHO grades
tissue_expression_down	hsa-mir-145	Carcinoma, Breast, Triple Negative	27404381				D064726			While miR-21, miR-221 and miR-210 showed  significant over-expression, miR-195 and miR-145 were downregulated and well correlated with various clinicopathological and demographic risk factors, tumor grade, clinical stage and hormone receptor status.
tissue_expression_down	hsa-mir-195	Carcinoma, Breast, Triple Negative	27404381				D064726			While miR-21, miR-221 and miR-210 showed  significant over-expression, miR-195 and miR-145 were downregulated and well correlated with various clinicopathological and demographic risk factors, tumor grade, clinical stage and hormone receptor status.
tissue_expression_down	hsa-mir-200c	Carcinoma, Breast, Triple Negative	24821285				D064726			microRNA-200c downregulates XIAP expression to suppress proliferation and promote apoptosis of triple-negative breast cancer cells.
tissue_expression_down	hsa-mir-1246	Carcinoma, Cervical	26074491	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	The expression of miR-1246 is negatively correlated with cervical cancer procedure as well as HPV16E6 infection status and the miR-1246 may act as a diagnostic biomarker for cervical cancer. In addition, HPV16E6 infection may be a major reason leading to decrease the expression of miR-1246 in cervical cancer.This finding contributes to deep understanding of the miR-1246 function in cervical carcinogenesis.
tissue_expression_down	hsa-mir-126	Carcinoma, Cervical	25551621	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	miR-126 expression level in human cervical cancer tissues was significantly lower than that in adjacent nontumorous tissues
tissue_expression_down	hsa-mir-132	Carcinoma, Cervical	25988335	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	miR-212/132 downregulates SMAD2 expression to suppress the G1/S phase transition of the cell cycle and the epithelial to mesenchymal transition in cervical cancer cells.
tissue_expression_down	hsa-mir-135b	Carcinoma, Cervical	26617737	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	In conclusion, down-regulation of miR-135b inhibited cell growth in cervical cancer cells by up-regulation of FOXO1.
tissue_expression_down	hsa-mir-145	Carcinoma, Cervical	25560490	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	downregulation of miR-145 in cervical cancer is associated with aggressive progression and poor prognosis and that miR-145 may serve as a prognostic marker.
tissue_expression_down	hsa-mir-196a	Carcinoma, Cervical	25563170	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	HPV16 E5 specifically down-regulates miR196a upon infection of the human cervix and initiates the transformation of normal cervix cells to cervical carcinoma.
tissue_expression_down	hsa-mir-212	Carcinoma, Cervical	25988335	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	miR-212/132 downregulates SMAD2 expression to suppress the G1/S phase transition of the cell cycle and the epithelial to mesenchymal transition in cervical cancer cells.
tissue_expression_down	hsa-mir-218-1	Carcinoma, Cervical	21309487	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	infection with high-risk HPV lowered the expression of miR-218 and that down-regulation of miR-218 was involved in the pathogenesis of cervical cancer
tissue_expression_down	hsa-mir-218-2	Carcinoma, Cervical	21309487	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	infection with high-risk HPV lowered the expression of miR-218 and that down-regulation of miR-218 was involved in the pathogenesis of cervical cancer
tissue_expression_down	hsa-mir-26b	Carcinoma, Cervical	26191262	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	Our results showed that reduced miR-26b was correlated with tumor development and poor prognosis in human cervical cancer. The status of miR-26b expression may be a potential prognostic biomarker for cervical cancer patients.
tissue_expression_down	hsa-mir-3156	Carcinoma, Cervical	28160779	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	miR-3156-3p is downregulated in HPV-positive cervical cancer and performs as a tumor-suppressive miRNA.
tissue_expression_down	hsa-mir-503	Carcinoma, Cervical	26592830	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	Reduced expression of miR-503 is an independent prognostic factor in cervical cancer indicating poor prognosis.
tissue_expression_down	hsa-mir-1295	Carcinoma, Colon	28193082	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Expression Analysis of Previously Verified Fecal and Plasma Dow-regulated MicroRNAs (miR-4478, 1295-3p, 142-3p and 26a-5p), in FFPE Tissue Samples of CRC Patients.
tissue_expression_down	hsa-mir-142	Carcinoma, Colon	28193082	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Expression Analysis of Previously Verified Fecal and Plasma Dow-regulated MicroRNAs (miR-4478, 1295-3p, 142-3p and 26a-5p), in FFPE Tissue Samples of CRC Patients.
tissue_expression_down	hsa-mir-143	Carcinoma, Colon	27906435	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Down-regulation of microRNA-143 is associated with colorectal cancer progression.
tissue_expression_down	hsa-mir-21	Carcinoma, Colon	23894315	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Difluorinated-curcumin (CDF) restores PTEN expression in colon cancer cells by down-regulating miR-21.
tissue_expression_down	hsa-mir-26a	Carcinoma, Colon	28193082	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Expression Analysis of Previously Verified Fecal and Plasma Dow-regulated MicroRNAs (miR-4478, 1295-3p, 142-3p and 26a-5p), in FFPE Tissue Samples of CRC Patients.
tissue_expression_down	hsa-mir-4478	Carcinoma, Colon	28193082	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Expression Analysis of Previously Verified Fecal and Plasma Dow-regulated MicroRNAs (miR-4478, 1295-3p, 142-3p and 26a-5p), in FFPE Tissue Samples of CRC Patients.
tissue_expression_down	hsa-mir-145	Carcinoma, Endometrioid Endometrial	29569698			C54.1	D018269			miRNA-145 expression was lower in DPEEOC endometrial tissues and higher in DPEEOC ovarian tissues compared to the corresponding normal tissues
tissue_expression_down	hsa-mir-197	Carcinoma, Esophageal	25117314	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	Implications of microRNA-197 downregulated expression in esophageal cancer with poor prognosis.
tissue_expression_down	hsa-mir-203	Carcinoma, Esophageal	24001611	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	MiR-203 suppresses tumor growth and invasion and down-regulates MiR-21 expression through repressing Ran in esophageal cancer.
tissue_expression_down	hsa-mir-21	Carcinoma, Esophageal	24001611	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	MiR-203 suppresses tumor growth and invasion and down-regulates MiR-21 expression through repressing Ran in esophageal cancer.
tissue_expression_down	hsa-mir-625	Carcinoma, Esophageal	24508466	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	miR-625 down-regulation promotes proliferation and invasion in esophageal cancer by targeting Sox2.
tissue_expression_down	hsa-mir-148a	Carcinoma, Gastric	28475823	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	Down-regulated miRs specifically correlate with non-cardial gastric cancers and Lauren's classification system.
tissue_expression_down	hsa-mir-199a	Carcinoma, Gastric	24065659	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	MicroRNA-199a-3p is downregulated in gastric carcinomas and modulates cell proliferation.
tissue_expression_down	hsa-mir-204	Carcinoma, Gastric	28475823	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	Down-regulated miRs specifically correlate with non-cardial gastric cancers and Lauren's classification system.
tissue_expression_down	hsa-mir-224	Carcinoma, Gastric	25017365	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	the down-regulation of RKIP expression was observed in human gastric cell lines, and miR-224 could negatively regulate the expression and biological characteristics of RKIP, contributing to suppress the proliferation and invasion of gastric cells.
tissue_expression_down	hsa-mir-31	Carcinoma, Gastric	28475823	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	Down-regulated miRs specifically correlate with non-cardial gastric cancers and Lauren's classification system.
tissue_expression_down	hsa-mir-375	Carcinoma, Gastric	28475823	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	Down-regulated miRs specifically correlate with non-cardial gastric cancers and Lauren's classification system.
tissue_expression_down	hsa-mir-939	Carcinoma, Gastric	28114937	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway.
tissue_expression_down	hsa-mir-665	Carcinoma, Gastric, Signet Ring Cell	25964059				D018279			It was concluded that hsa-miR-665 and hsa-miR-95 were downregulated in GSRCC but upregulated in intestinal gastric adenocarcinoma, and the relatively differential expression of the miRNAs negatively controlling their target genes could be closely related to the high invasive metastasis and chemoresistance of GSRCC.
tissue_expression_down	hsa-mir-95	Carcinoma, Gastric, Signet Ring Cell	25964059				D018279			It was concluded that hsa-miR-665 and hsa-miR-95 were downregulated in GSRCC but upregulated in intestinal gastric adenocarcinoma, and the relatively differential expression of the miRNAs negatively controlling their target genes could be closely related to the high invasive metastasis and chemoresistance of GSRCC.
tissue_expression_down	hsa-let-7a	Carcinoma, Hepatocellular	29314614	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-1, miR-122, let-7a, and let-7g were downregulated, whereas miR-10b and miR-21 were upregulated in canine HCC
tissue_expression_down	hsa-let-7c	Carcinoma, Hepatocellular	22289550	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Levels of let-7c miRNA were significantly lower in HCC tissues than in corresponding normal adjacent tumour tissues and there was a correlation between the downregulation of let-7c and poor tissue differentiation in HCC.
tissue_expression_down	hsa-let-7c	Carcinoma, Hepatocellular	18006136	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	These mice do not exhibit downregulation of let-7c gene expression thus forming the basis for the resistance to hepatocellular carcinogenesis.
tissue_expression_down	hsa-let-7g	Carcinoma, Hepatocellular	29314614	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-1, miR-122, let-7a, and let-7g were downregulated, whereas miR-10b and miR-21 were upregulated in canine HCC
tissue_expression_down	hsa-mir-1	Carcinoma, Hepatocellular	29314614	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-1, miR-122, let-7a, and let-7g were downregulated, whereas miR-10b and miR-21 were upregulated in canine HCC
tissue_expression_down	hsa-mir-106b	Carcinoma, Hepatocellular	23087084	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma
tissue_expression_down	hsa-mir-107	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-10a	Carcinoma, Hepatocellular	22976466	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Significant downregulation of miR-10a was observed in tumor compared with non-tumor tissues (0.50 vs. 1.73, p = 0.031).
tissue_expression_down	hsa-mir-122	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-122: be decreased in HCC compared to non-tumoral tissue
tissue_expression_down	hsa-mir-122	Carcinoma, Hepatocellular	19711427	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	down-regulation at early stage
tissue_expression_down	hsa-mir-122	Carcinoma, Hepatocellular	20859956	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-122a:microRNA-122a (miR-122a) is a liver-specific miRNA that is frequently downregulated in hepatocellular carcinoma (HCC)
tissue_expression_down	hsa-mir-122	Carcinoma, Hepatocellular	21750653	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The down-regulation of miR-122 activated the CDK4-PSMD10-UPR pathway to decrease tumor cell anticancer drug-mediated apoptosis.
tissue_expression_down	hsa-mir-122	Carcinoma, Hepatocellular	22174818	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Although miR-222, miR-223 or miR-21 were significantly up- or down-regulated between HCC patients and healthy controls, no significant difference was observed in the levels of these miRNAs between HBV patients without and with HCC. MiR-122 in serum was significantly higher in HCC patients than healthy controls (p<0.001). More importantly, it was found that the levels of miR-122 were significantly reduced in the post-operative serum samples when compared to the pre-operative samples. Although serum miR-122 was also elevated in HBV patients with HCC comparing with those without HCC, the difference was at the border line (p=0.043).
tissue_expression_down	hsa-mir-122	Carcinoma, Hepatocellular	22312705	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MiR-122 increases sensitivity of drug-resistant BEL-7402/5-FU cells to 5-fluorouracil via down-regulation of bcl-2 family proteins.
tissue_expression_down	hsa-mir-122	Carcinoma, Hepatocellular	23727126	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-122, a liver-specific tumor suppressor microRNA, is frequently down-regulated in hepatocellular carcinoma (HCC)
tissue_expression_down	hsa-mir-122	Carcinoma, Hepatocellular	29314614	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-1, miR-122, let-7a, and let-7g were downregulated, whereas miR-10b and miR-21 were upregulated in canine HCC
tissue_expression_down	hsa-mir-1228	Carcinoma, Hepatocellular	25422913	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-1228 functions as an oncogene by promoting cell cycle progression and cell mobility and negatively regulates the expression of p53. p53 downregulation in turn leads to an increase in miR-1228 expression, thereby forming a positive feedback loop that contributes to cancerogenesis in HCC.
tissue_expression_down	hsa-mir-1228	Carcinoma, Hepatocellular	23205106	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection.
tissue_expression_down	hsa-mir-1246	Carcinoma, Hepatocellular	25159494	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Our study showed that miR-1246, by down-regulation CADM1, enhances migration and invasion in HCC cells.
tissue_expression_down	hsa-mir-1249	Carcinoma, Hepatocellular	23205106	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection.
tissue_expression_down	hsa-mir-125a	Carcinoma, Hepatocellular	16331254	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	downregulated
tissue_expression_down	hsa-mir-125a	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-125b-1	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-125b-2	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-1275	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_down	hsa-mir-129	Carcinoma, Hepatocellular	23205106	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection.
tissue_expression_down	hsa-mir-1290	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-1290 was down-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_down	hsa-mir-129-1	Carcinoma, Hepatocellular	22536440	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	VCP/p97, down-regulated by microRNA-129-5p, could regulate the progression of hepatocellular carcinoma.
tissue_expression_down	hsa-mir-129-2	Carcinoma, Hepatocellular	22536440	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	VCP/p97, down-regulated by microRNA-129-5p, could regulate the progression of hepatocellular carcinoma.
tissue_expression_down	hsa-mir-130a	Carcinoma, Hepatocellular	25218269	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MicroRNA-130a is down-regulated in hepatocellular carcinoma and associates with poor prognosis.
tissue_expression_down	hsa-mir-133b	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-134	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-138	Carcinoma, Hepatocellular	25439221	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	the combined expression of miR-138 and its direct target CCND3 may be correlated with significant characteristics of HCC. MiR-138 downregulation and CCND3 upregulation maybe concurrently associated with  prognosis in patients with HCC.
tissue_expression_down	hsa-mir-138	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_down	hsa-mir-139	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-139	Carcinoma, Hepatocellular	24549282	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Downregulation of microRNA-139 is associated with hepatocellular carcinoma risk and short-term survival.
tissue_expression_down	hsa-mir-142	Carcinoma, Hepatocellular	26293610	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility.
tissue_expression_down	hsa-mir-143	Carcinoma, Hepatocellular	25270212	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The miR-143 expression was low in hepatic carcinoma and its over-expression could down-regulate the expressions of TLR2, NF-κB, MMP-2 and MMP-9.
tissue_expression_down	hsa-mir-143	Carcinoma, Hepatocellular	26722463	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-143 down-regulates TLR2 expression in hepatoma cells and inhibits hepatoma cell proliferation and invasion.
tissue_expression_down	hsa-mir-144	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-145	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-145: be decreased in HCC compared to non-tumoral tissue
tissue_expression_down	hsa-mir-145	Carcinoma, Hepatocellular	22213236	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	down-regulated in HCC tissues.
tissue_expression_down	hsa-mir-145	Carcinoma, Hepatocellular	26512974	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	HBV infection promotes cell growth, at least partially, through the HBX-induced downregulation of miRNA-145 expression, which is responsible for the oncogenesis of HBV-associated HCC.
tissue_expression_down	hsa-mir-145	Carcinoma, Hepatocellular	18307259	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-122, miR-100, and miR-10a were overexpressed whereas miR-198 and miR-145 were up to 5-fold down-regulated in hepatic tumors compared to normal liver parenchyma.
tissue_expression_down	hsa-mir-146	Carcinoma, Hepatocellular	23205106	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection.
tissue_expression_down	hsa-mir-146a	Carcinoma, Hepatocellular	21829663	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miRNAs miR-26a, -29c, -146a and -190 were significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues.
tissue_expression_down	hsa-mir-146a	Carcinoma, Hepatocellular	22213236	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	down-regulated in HCC tissues.
tissue_expression_down	hsa-mir-146a	Carcinoma, Hepatocellular	24172202	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Down-regulation of miR-146a is related to HCC carcinogenesis and deterioration of HCC. MicroRNA-146a may act as a suppressor miRNA of HCC, and it is therefore a potential prognostic biomarker for HCC patients.
tissue_expression_down	hsa-mir-148a	Carcinoma, Hepatocellular	25444499	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Underexpression of miR-148a might be associated with HCC tumorigenesis and deterioration of HCC. miR-148a might act as a suppressor miRNA  of HCC and it therefore has a potential role in prognosis of HCC patients.
tissue_expression_down	hsa-mir-148a	Carcinoma, Hepatocellular	26248880	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Down-regulation of miR-148a is related to HCC carcinogenesis and deterioration of HCC. MicroRNA-148a may act as a suppressor miRNA of HCC, and it is therefore a potential prognostic biomarker for HCC patients.
tissue_expression_down	hsa-mir-148b	Carcinoma, Hepatocellular	24805877	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MicroRNA-148b expression is decreased in hepatocellular carcinoma and associated  with prognosis.
tissue_expression_down	hsa-mir-150	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-151a	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-155	Carcinoma, Hepatocellular	19711427	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Real-time reverse transcription polymerase chain reaction (RT-PCR) analysis demonstrated up-regulation of oncogenic miR-155, miR-221/222, and miR-21 and down-regulation of the most abundant liver-specific miR-122 at early stages of hepatocarcinogenesis.
tissue_expression_down	hsa-mir-15a	Carcinoma, Hepatocellular	21629246	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro.
tissue_expression_down	hsa-mir-15a	Carcinoma, Hepatocellular	22033921	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The microRNA 15/16 cluster downregulates protein repair isoaspartyl methyltransferase in hepatoma cells. The authors conclude that PCMT is effectively regulated by the miR15a-16-1 cluster and is involved in apoptosis by preserving the structural stability and biological function of BclxL from deamidation. Control of PCMT expression by snRNAs may thus represent a late check point in apoptosis regulation.
tissue_expression_down	hsa-mir-16-1	Carcinoma, Hepatocellular	21629246	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro.
tissue_expression_down	hsa-mir-16-1	Carcinoma, Hepatocellular	22033921	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The microRNA 15/16 cluster downregulates protein repair isoaspartyl methyltransferase in hepatoma cells. The authors conclude that PCMT is effectively regulated by the miR15a-16-1 cluster and is involved in apoptosis by preserving the structural stability and biological function of BclxL from deamidation. Control of PCMT expression by snRNAs may thus represent a late check point in apoptosis regulation.
tissue_expression_down	hsa-mir-16-2	Carcinoma, Hepatocellular	21629246	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro.
tissue_expression_down	hsa-mir-181c	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-182	Carcinoma, Hepatocellular	22681717	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma.
tissue_expression_down	hsa-mir-187	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-187* was down-regulated in HepG2 cells after 5 hours of culture with cocoa proanthocyanidin extract.
tissue_expression_down	hsa-mir-18a	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-18b	Carcinoma, Hepatocellular	23205106	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection.
tissue_expression_down	hsa-mir-190a	Carcinoma, Hepatocellular	21829663	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miRNAs miR-26a, -29c, -146a and -190 were significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues.
tissue_expression_down	hsa-mir-193a	Carcinoma, Hepatocellular	26263159	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MiR-193a-3p may be a tumor-suppressive miRNA which is down-regulated in HCC tissues. It could be regarded as a predictor for the deterioration of HCC patients.
tissue_expression_down	hsa-mir-195	Carcinoma, Hepatocellular	16331254	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	downregulated
tissue_expression_down	hsa-mir-195	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-197	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-198	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-198: up to five-fold down-regulated in hepatic tumors compared to normal liver parenchyma
tissue_expression_down	hsa-mir-198	Carcinoma, Hepatocellular	18307259	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-122, miR-100, and miR-10a were overexpressed whereas miR-198 and miR-145 were up to 5-fold down-regulated in hepatic tumors compared to normal liver parenchyma.
tissue_expression_down	hsa-mir-199a	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_down	hsa-mir-199a-1	Carcinoma, Hepatocellular	16331254	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	downregulated
tissue_expression_down	hsa-mir-199a-1	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-199a: be decreased in HCC compared to non-tumoral tissue
tissue_expression_down	hsa-mir-199a-1	Carcinoma, Hepatocellular	22713463	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell.
tissue_expression_down	hsa-mir-199a-2	Carcinoma, Hepatocellular	16331254	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	downregulated
tissue_expression_down	hsa-mir-199a-2	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-199a: be decreased in HCC compared to non-tumoral tissue
tissue_expression_down	hsa-mir-199a-2	Carcinoma, Hepatocellular	22713463	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell.
tissue_expression_down	hsa-mir-199b	Carcinoma, Hepatocellular	21557766	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-199b-5p: Patients with lower levels of miR-199b expression had poorer overall survival and progression-free survival rates, whereas patients with higher levels of miR-199b expression had better survival.
tissue_expression_down	hsa-mir-19a	Carcinoma, Hepatocellular	27012708	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells.
tissue_expression_down	hsa-mir-200a	Carcinoma, Hepatocellular	16331254	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	downregulated
tissue_expression_down	hsa-mir-200a	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-200c	Carcinoma, Hepatocellular	22213236	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	down-regulated in HCC tissues.
tissue_expression_down	hsa-mir-200c	Carcinoma, Hepatocellular	26940140	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Expression of miR-200c and  miR-34a in the RFA group was significantly lower than that in the non-RFA group
tissue_expression_down	hsa-mir-202	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-204	Carcinoma, Hepatocellular	25652855	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Growth inhibition of human hepatocellular carcinoma by miRNA-204 via down-regulation of Bcl-2 and Sirt1 expression.
tissue_expression_down	hsa-mir-208a	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-208b	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-21	Carcinoma, Hepatocellular	19711427	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Real-time reverse transcription polymerase chain reaction (RT-PCR) analysis demonstrated up-regulation of oncogenic miR-155, miR-221/222, and miR-21 and down-regulation of the most abundant liver-specific miR-122 at early stages of hepatocarcinogenesis.
tissue_expression_down	hsa-mir-21	Carcinoma, Hepatocellular	22174818	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Although miR-222, miR-223 or miR-21 were significantly up- or down-regulated between HCC patients and healthy controls, no significant difference was observed in the levels of these miRNAs between HBV patients without and with HCC. MiR-122 in serum was significantly higher in HCC patients than healthy controls (p<0.001). More importantly, it was found that the levels of miR-122 were significantly reduced in the post-operative serum samples when compared to the pre-operative samples. Although serum miR-122 was also elevated in HBV patients with HCC comparing with those without HCC, the difference was at the border line (p=0.043).
tissue_expression_down	hsa-mir-21	Carcinoma, Hepatocellular	26222667	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	These results demonstrated that p53 is responsible for the anti-tumor effect of BA through up-regulation of p66(shc) and miR-21 and down-regulation of Sod2 expression, leading to mitochondrial ROS accumulation and apoptosis. The p53-p66(shc)/miR-21-Sod2 signaling is critical for BA-inhibited tumor growth and cancer cell proliferation.
tissue_expression_down	hsa-mir-21	Carcinoma, Hepatocellular	25775917	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The down-expression of miR-431 is partially responsible for a series of clinicopathological features which may be tightly correlated with the progression of HCC. Thus, expression of miR-431 may be proposed as a new factor in association with the progression of HCC.
tissue_expression_down	hsa-mir-2110	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-2110 was down-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_down	hsa-mir-2116	Carcinoma, Hepatocellular	23205106	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection.
tissue_expression_down	hsa-mir-212	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-214	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-214	Carcinoma, Hepatocellular	22613005	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma.
tissue_expression_down	hsa-mir-214	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_down	hsa-mir-214	Carcinoma, Hepatocellular	24129885	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	the upregulation of miR-130b and downregulation of miR-199a-5p, miR-199b-5p, and miR-214 were more significant in HCC cell lines
tissue_expression_down	hsa-mir-217	Carcinoma, Hepatocellular	27879964	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Decreased levels of miR-34a and miR-217 act as predictor biomarkers of aggressive progression and poor prognosis in hepatocellular carcinoma.
tissue_expression_down	hsa-mir-22	Carcinoma, Hepatocellular	23766411	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-22 is downregulated in HCC and its expression is associated with the differentiation, metastasis and prognosis of the carcinoma. Ezrin is a potential regulatory protein of miR-22.
tissue_expression_down	hsa-mir-221	Carcinoma, Hepatocellular	19711427	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Real-time reverse transcription polymerase chain reaction (RT-PCR) analysis demonstrated up-regulation of oncogenic miR-155, miR-221/222, and miR-21 and down-regulation of the most abundant liver-specific miR-122 at early stages of hepatocarcinogenesis.
tissue_expression_down	hsa-mir-221	Carcinoma, Hepatocellular	21876625	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	downregulated in acute HBV infection, normally expressed in chronic HBV infection, and upregulated in HCC
tissue_expression_down	hsa-mir-221	Carcinoma, Hepatocellular	25775917	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The down-expression of miR-431 is partially responsible for a series of clinicopathological features which may be tightly correlated with the progression of HCC. Thus, expression of miR-431 may be proposed as a new factor in association with the progression of HCC.
tissue_expression_down	hsa-mir-222	Carcinoma, Hepatocellular	19711427	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Real-time reverse transcription polymerase chain reaction (RT-PCR) analysis demonstrated up-regulation of oncogenic miR-155, miR-221/222, and miR-21 and down-regulation of the most abundant liver-specific miR-122 at early stages of hepatocarcinogenesis.
tissue_expression_down	hsa-mir-222	Carcinoma, Hepatocellular	22174818	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Although miR-222, miR-223 or miR-21 were significantly up- or down-regulated between HCC patients and healthy controls, no significant difference was observed in the levels of these miRNAs between HBV patients without and with HCC. MiR-122 in serum was significantly higher in HCC patients than healthy controls (p<0.001). More importantly, it was found that the levels of miR-122 were significantly reduced in the post-operative serum samples when compared to the pre-operative samples. Although serum miR-122 was also elevated in HBV patients with HCC comparing with those without HCC, the difference was at the border line (p=0.043).
tissue_expression_down	hsa-mir-223	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-223	Carcinoma, Hepatocellular	22174818	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Although miR-222, miR-223 or miR-21 were significantly up- or down-regulated between HCC patients and healthy controls, no significant difference was observed in the levels of these miRNAs between HBV patients without and with HCC. MiR-122 in serum was significantly higher in HCC patients than healthy controls (p<0.001). More importantly, it was found that the levels of miR-122 were significantly reduced in the post-operative serum samples when compared to the pre-operative samples. Although serum miR-122 was also elevated in HBV patients with HCC comparing with those without HCC, the difference was at the border line (p=0.043).
tissue_expression_down	hsa-mir-223	Carcinoma, Hepatocellular	22213236	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	down-regulated in HCC tissues.
tissue_expression_down	hsa-mir-223	Carcinoma, Hepatocellular	23925649	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MiR-223 modulates multidrug resistance via downregulation of ABCB1 in hepatocellular carcinoma cells.
tissue_expression_down	hsa-mir-224	Carcinoma, Hepatocellular	25775917	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The down-expression of miR-431 is partially responsible for a series of clinicopathological features which may be tightly correlated with the progression of HCC. Thus, expression of miR-431 may be proposed as a new factor in association with the progression of HCC.
tissue_expression_down	hsa-mir-24-1	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-24-2	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-26a-1	Carcinoma, Hepatocellular	21829663	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miRNAs miR-26a, -29c, -146a and -190 were significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues.
tissue_expression_down	hsa-mir-26a-2	Carcinoma, Hepatocellular	21829663	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miRNAs miR-26a, -29c, -146a and -190 were significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues.
tissue_expression_down	hsa-mir-296	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-296	Carcinoma, Hepatocellular	23205106	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection.
tissue_expression_down	hsa-mir-29c	Carcinoma, Hepatocellular	21829663	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miRNAs miR-26a, -29c, -146a and -190 were significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues.
tissue_expression_down	hsa-mir-30b	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-30b* was down-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_down	hsa-mir-30d	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-320a	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-320b-1	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-320b-2	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-320c-1	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-320c was down-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_down	hsa-mir-320c-1	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-320c-2	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-320c was down-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_down	hsa-mir-320d-1	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-320e	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-323b	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-453 (note: this miRNA was replaced by hsa-mir-323b) was down-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_down	hsa-mir-324	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-326	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-330	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-33a	Carcinoma, Hepatocellular	24015284	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-33a down-regulated β-catenin by directly binding to the 3'-UTR of β-catenin. These results suggested that AFB1 might down-regulate β-catenin by up-regulating miR-33a. This understanding opens new lines of thought in the potential role of miR-33a in the  clinical therapy of cancer.
tissue_expression_down	hsa-mir-33a	Carcinoma, Hepatocellular	27460728	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MiR-33a downregulation in HCC cells is hypoxia-induced and is a result of HIFs upregulation. MiR-33a can modulate EMT and invasion of hepatocellular cancer cells at least partly via downregulating Twist1.
tissue_expression_down	hsa-mir-33a	Carcinoma, Hepatocellular	28291769	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Downregulation of miR-33a-5p in Hepatocellular Carcinoma: A Possible Mechanism for Chemotherapy Resistance.
tissue_expression_down	hsa-mir-345	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-346	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-34a	Carcinoma, Hepatocellular	27879964	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Decreased levels of miR-34a and miR-217 act as predictor biomarkers of aggressive progression and poor prognosis in hepatocellular carcinoma.
tissue_expression_down	hsa-mir-361	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-365a	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-365b	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-370	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-371	Carcinoma, Hepatocellular	23466643	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-371-5p down-regulates pre mRNA processing factor 4 homolog B (PRPF4B) and facilitates the G1/S transition in human hepatocellular carcinoma cells
tissue_expression_down	hsa-mir-373	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-378a	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-381	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-409	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-423	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-424	Carcinoma, Hepatocellular	24675898	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MicroRNA-424 is down-regulated in hepatocellular carcinoma and suppresses cell migration and invasion through c-Myb.
tissue_expression_down	hsa-mir-431	Carcinoma, Hepatocellular	25775917	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The down-expression of miR-431 is partially responsible for a series of clinicopathological features which may be tightly correlated with the progression of HCC. Thus, expression of miR-431 may be proposed as a new factor in association with the progression of HCC.
tissue_expression_down	hsa-mir-433	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_down	hsa-mir-448	Carcinoma, Hepatocellular	23205106	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection.
tissue_expression_down	hsa-mir-483	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-483-5p was down-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_down	hsa-mir-483	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-483	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_down	hsa-mir-484	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-485	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-486	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-486	Carcinoma, Hepatocellular	25475121	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-486-5p, which is frequently downregulated in HCC, inhibits HCC progression by targeting PIK3R1 and phosphatidylinositol 3-kinase-AKT activation.
tissue_expression_down	hsa-mir-489	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-490	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-492	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-497	Carcinoma, Hepatocellular	26336827	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In conclusion,our findings indicate that miR-497 downregulation contributes to angiogenesis and metastasis in HCC.
tissue_expression_down	hsa-mir-498	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-500a	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-500b	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-503	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-511	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_down	hsa-mir-518b	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-520d	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-520e	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-520e was down-regulated in HepG2 cells after 5 hours of culture with epigallocatechin gallate.
tissue_expression_down	hsa-mir-526a-1	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-526a-2	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-526b	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-527	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-542	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-557	Carcinoma, Hepatocellular	23205106	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection.
tissue_expression_down	hsa-mir-581	Carcinoma, Hepatocellular	23205106	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection.
tissue_expression_down	hsa-mir-592	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_down	hsa-mir-608	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-608 was down-regulated in HepG2 cells after 5 hours of culture with epigallocatechin gallate.
tissue_expression_down	hsa-mir-610	Carcinoma, Hepatocellular	25491321	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-610 downregulation plays essential roles in HCC progression and reduced miR-610 is correlated with Wnt/β-catenin signaling pathway.
tissue_expression_down	hsa-mir-625	Carcinoma, Hepatocellular	23205106	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection.
tissue_expression_down	hsa-mir-629	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-629 was down-regulated in HepG2 cells after 5 hours of culture with epigallocatechin gallate.
tissue_expression_down	hsa-mir-650	Carcinoma, Hepatocellular	22767438	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Upregulation of miR-650 is correlated with down-regulation of ING4 and progression of hepatocellular carcinoma.
tissue_expression_down	hsa-mir-655	Carcinoma, Hepatocellular	28272708	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Down-regulation of miR-655-3p predicts worse clinical outcome in patients suffering from hepatocellular carcinoma.
tissue_expression_down	hsa-mir-694	Carcinoma, Hepatocellular	25333455	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Knockout of the HCC suppressor gene Lass2 downregulates the expression level of miR-694.
tissue_expression_down	hsa-mir-708	Carcinoma, Hepatocellular	26211597	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Our findings support that miR-708, which is frequently down-regulated in HCC, may contribute to the aggressive progression of HCC and inhibit HCC cell mobility. Further studies on the identification of its target genes are required to be performed.
tissue_expression_down	hsa-mir-708	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_down	hsa-mir-744	Carcinoma, Hepatocellular	25543521	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Our results associate decreased miR-744  expression with HCC recurrence and prognosis, and also suggest that miR-744 is an independent predictor of survival in HCC patients after LT and may therefore be a potential biomarker for their prognosis.
tissue_expression_down	hsa-mir-765	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-765 was down-regulated in HepG2 cells after 5 hours of culture with cocoa proanthocyanidin extract.
tissue_expression_down	hsa-mir-92a-1	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-92a-2	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-92b	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-93	Carcinoma, Hepatocellular	25775917	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The down-expression of miR-431 is partially responsible for a series of clinicopathological features which may be tightly correlated with the progression of HCC. Thus, expression of miR-431 may be proposed as a new factor in association with the progression of HCC.
tissue_expression_down	hsa-mir-942	Carcinoma, Hepatocellular	24970806	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT.
tissue_expression_down	hsa-mir-96	Carcinoma, Hepatocellular	27012708	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	ANT2 shRNA downregulates miR-19a and miR-96 through the PI4K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells.
tissue_expression_down	hsa-mir-96	Carcinoma, Hepatocellular	18433021	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-96 was overexpressed in HBV tumors, and miR-126* was down-regulated in alcohol-related hepatocellular carcinoma.
tissue_expression_down	hsa-mir-99a	Carcinoma, Hepatocellular	21878637	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Lower miR-99a expression in HCC tissues significantly correlated with shorter survival of HCC patients, and miR-99a was identified to be an independent predictor for prognosis of HCC patients. Furthermore, restoration of miR-99a dramatically suppressed HCC cell growth in vitro by inducing G1 phase cell cycle arrest.
tissue_expression_down	hsa-mir-99b	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was down-regulated in HepG2 cells treated with BJA32515.
tissue_expression_down	hsa-mir-143	Carcinoma, Hepatocellular, HBV-Related	29616093							These results indicated that the decreased expression of the miR-143/145 cluster and their host gene MIR143HG in HBV-associated HCC tissue was associated with prognosis, and each of  these miRNAs may serve as a valuable diagnostic biomarker for predicting HBV-associated HCC tumorigenesis
tissue_expression_down	hsa-mir-145	Carcinoma, Hepatocellular, HBV-Related	29616093							These results indicated that the decreased expression of the miR-143/145 cluster and their host gene MIR143HG in HBV-associated HCC tissue was associated with prognosis, and each of  these miRNAs may serve as a valuable diagnostic biomarker for predicting HBV-associated HCC tumorigenesis
tissue_expression_down	hsa-mir-1290	Carcinoma, Laryngeal	26694163	disease of cellular proliferation	DOID:2600	C32.3	D007822	21198	HP:0012118	Taken together, we propose miR-1290 as the new oncomiR involved in LSCC pathogenesis. Additionally, we suggest that the oncogenic potential of miR-1290 might be expressed by the involvement in downregulation of its target genes MAF and ITPR2.
tissue_expression_down	hsa-mir-519b	Carcinoma, Laryngeal	24742516	disease of cellular proliferation	DOID:2600	C32.3	D007822	21198	HP:0012118	The expression of MiR-519b-3p as carcinoma suppressor gene is low in laryngeal carcinoma. The cell cycle of Hep-2 cells was arrested in the G2/M phase by MiR-519b-3p.
tissue_expression_down	hsa-mir-200b	Carcinoma, Lung	27189341	disease of cellular proliferation	DOID:3905	C34.90	D008175			carcinomas exhibiting lymph vessel invasion had significantly lower expression of miR-200a (P=.0230) and miR-200b (P=.0168)
tissue_expression_down	hsa-let-7e	Carcinoma, Lung, Non-Small-Cell	22618509			C34.90	D002289		HP:0030358	We showed that, compared to adjacent non-neoplastic lung tissues, the expressions of miR-125a-5p and let-7e were decreased in AD and SCC samples
tissue_expression_down	hsa-mir-10a	Carcinoma, Lung, Non-Small-Cell	26870288			C34.90	D002289		HP:0030358	miR-10a and -26b were downregulated in FF NSCLC tissues
tissue_expression_down	hsa-mir-125a	Carcinoma, Lung, Non-Small-Cell	22618509			C34.90	D002289		HP:0030358	We showed that, compared to adjacent non-neoplastic lung tissues, the expressions of miR-125a-5p and let-7e were decreased in AD and SCC samples
tissue_expression_down	hsa-mir-126	Carcinoma, Lung, Non-Small-Cell	25384507			C34.90	D002289		HP:0030358	In tumor samples, we found downregulation of miR-15a/16 (50/83.3%), miR-34a (83.3%), miR-126 (70%), and miR-128 (63.3%).
tissue_expression_down	hsa-mir-133a	Carcinoma, Lung, Non-Small-Cell	27282282			C34.90	D002289		HP:0030358	miR-133a was down-regulated in NSCLC
tissue_expression_down	hsa-mir-141	Carcinoma, Lung, Non-Small-Cell	26783187			C34.90	D002289		HP:0030358	induction of miR-200b or miR-141 enhanced sensitivity to nintedanib in nintedanib-resistant A549 and PC1-R cells.
tissue_expression_down	hsa-mir-200a	Carcinoma, Lung, Non-Small-Cell	26783187			C34.90	D002289		HP:0030358	induction of miR-200b or miR-141 enhanced sensitivity to nintedanib in nintedanib-resistant A549 and PC1-R cells.
tissue_expression_down	hsa-mir-200b	Carcinoma, Lung, Non-Small-Cell	26783187			C34.90	D002289		HP:0030358	induction of miR-200b or miR-141 enhanced sensitivity to nintedanib in nintedanib-resistant A549 and PC1-R cells.
tissue_expression_down	hsa-mir-26a	Carcinoma, Lung, Non-Small-Cell	27447710			C34.90	D002289		HP:0030358	Additionally, statistically significant negative correlation was found between MMP-2 expression and its regulatory miR-26a.
tissue_expression_down	hsa-mir-26b	Carcinoma, Lung, Non-Small-Cell	23207443			C34.90	D002289		HP:0030358	SQCC was distinguished from normal tissue and ADC by high-level miR-205 expression and decreased miR-26b.
tissue_expression_down	hsa-mir-29b	Carcinoma, Lung, Non-Small-Cell	27447710			C34.90	D002289		HP:0030358	The decrease in miRNA-29b expression was statistically significant and differentiated NSCLC histopathological subtypes.
tissue_expression_down	hsa-mir-429	Carcinoma, Lung, Non-Small-Cell	26783187			C34.90	D002289		HP:0030358	Expression of miR-200b, miR-200a and miR-141 belonging to the miR-200 family which contributes to epithelial-mesenchymal transition (EMT), was significantly lower
tissue_expression_down	hsa-mir-451	Carcinoma, Lung, Non-Small-Cell	28704499			C34.90	D002289		HP:0030358	The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases.
tissue_expression_down	hsa-mir-486	Carcinoma, Lung, Non-Small-Cell	27291819			C34.90	D002289		HP:0030358	miR-486-5p was down-regulated in adenocarcinoma
tissue_expression_down	hsa-let-7a-1	Carcinoma, Lung, Non-Small-Cell	21468581			C34.90	D002289		HP:0030358	Let-7a miRNAs were under-expressed in the blood of NSCLC patients, as well as NSCLC cells and NSCLC tissues, compared to normal controls.
tissue_expression_down	hsa-let-7a-1	Carcinoma, Lung, Non-Small-Cell	21544802			C34.90	D002289		HP:0030358	The expression of miR-146b, miR-221, let-7a, miR-155, miR-17-5p, miR-27a and miR-106a were significantly reduced in the serum of NSCLC cases while miR-29c was significantly increased.
tissue_expression_down	hsa-let-7a-2	Carcinoma, Lung, Non-Small-Cell	21468581			C34.90	D002289		HP:0030358	Let-7a miRNAs were under-expressed in the blood of NSCLC patients, as well as NSCLC cells and NSCLC tissues, compared to normal controls.
tissue_expression_down	hsa-let-7a-2	Carcinoma, Lung, Non-Small-Cell	21544802			C34.90	D002289		HP:0030358	The expression of miR-146b, miR-221, let-7a, miR-155, miR-17-5p, miR-27a and miR-106a were significantly reduced in the serum of NSCLC cases while miR-29c was significantly increased.
tissue_expression_down	hsa-let-7a-3	Carcinoma, Lung, Non-Small-Cell	21468581			C34.90	D002289		HP:0030358	Let-7a miRNAs were under-expressed in the blood of NSCLC patients, as well as NSCLC cells and NSCLC tissues, compared to normal controls.
tissue_expression_down	hsa-let-7a-3	Carcinoma, Lung, Non-Small-Cell	21544802			C34.90	D002289		HP:0030358	The expression of miR-146b, miR-221, let-7a, miR-155, miR-17-5p, miR-27a and miR-106a were significantly reduced in the serum of NSCLC cases while miR-29c was significantly increased.
tissue_expression_down	hsa-let-7b	Carcinoma, Lung, Non-Small-Cell	21544802			C34.90	D002289		HP:0030358	Reduced plasma expression of let-7b was modestly associated with worse cancer-specific mortality in all patients and reduced serum expression of miR-223 was modestly associated with cancer-specific mortality in stage IA/B patients.
tissue_expression_down	hsa-mir-1	Carcinoma, Lung, Non-Small-Cell	24328409			C34.90	D002289		HP:0030358	Low expression of miR-1 and overexpression of PIK3CA in NSCLC tissues may be useful predictors of lymph node metastasis and postoperative recurrence in patients with NSCLC.
tissue_expression_down	hsa-mir-125a	Carcinoma, Lung, Non-Small-Cell	20569443			C34.90	D002289		HP:0030358	miR-125a-3p:Hsa-miR-125a-3p and hsa-miR-125a-5p are downregulated in non-small cell lung cancer
tissue_expression_down	hsa-mir-126	Carcinoma, Lung, Non-Small-Cell	27072269			C34.90	D002289		HP:0030358	miR-15a/16, miR-34a, miR-126 and miR-128 were down-regulated significantly.
tissue_expression_down	hsa-mir-133a	Carcinoma, Lung, Non-Small-Cell	25903369			C34.90	D002289		HP:0030358	MiR-133a serves as a tumor-suppressive miRNA in human NSCLC, and its downregulation suggests deterioration in NSCLC patients.
tissue_expression_down	hsa-mir-134	Carcinoma, Lung, Non-Small-Cell	22937028			C34.90	D002289		HP:0030358	High expression of miR-100 and low expression of miRNA-93, miRNA-134, miRNA-151 and miRNA-345 were associated with poor survival in both the training and validation cohort.
tissue_expression_down	hsa-mir-143	Carcinoma, Lung, Non-Small-Cell	20363096			C34.90	D002289		HP:0030358	miR-143:Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis
tissue_expression_down	hsa-mir-145	Carcinoma, Lung, Non-Small-Cell	22835608			C34.90	D002289		HP:0030358	Low miR-145 and high miR-367 are associated with unfavorable prognosis in resected NSCLC.
tissue_expression_down	hsa-mir-148b	Carcinoma, Lung, Non-Small-Cell	25755777			C34.90	D002289		HP:0030358	our data indicate that decreased expression of miR-148b in NSCLC tissues has prognostic value.
tissue_expression_down	hsa-mir-150	Carcinoma, Lung, Non-Small-Cell	23228962			C34.90	D002289		HP:0030358	Expression of miR-150 and miR-3940-5p is reduced in non-small cell lung carcinoma and correlates with clinicopathological features
tissue_expression_down	hsa-mir-151a	Carcinoma, Lung, Non-Small-Cell	22937028			C34.90	D002289		HP:0030358	High expression of miR-100 and low expression of miRNA-93, miRNA-134, miRNA-151 and miRNA-345 were associated with poor survival in both the training and validation cohort.
tissue_expression_down	hsa-mir-151b	Carcinoma, Lung, Non-Small-Cell	22937028			C34.90	D002289		HP:0030358	High expression of miR-100 and low expression of miRNA-93, miRNA-134, miRNA-151 and miRNA-345 were associated with poor survival in both the training and validation cohort.
tissue_expression_down	hsa-mir-15a	Carcinoma, Lung, Non-Small-Cell	24500260			C34.90	D002289		HP:0030358	These findings clearly suggest that the downregulation of miR-15a-16 with Cripto amplification may be involved in the development of NSCLC.
tissue_expression_down	hsa-mir-181a-2	Carcinoma, Lung, Non-Small-Cell	20363096			C34.90	D002289		HP:0030358	miR-181a:Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis
tissue_expression_down	hsa-mir-181b	Carcinoma, Lung, Non-Small-Cell	23827213			C34.90	D002289		HP:0030358	Down-regulation of microRNA-181b is a potential prognostic marker of non-small cell lung cancer.
tissue_expression_down	hsa-mir-187	Carcinoma, Lung, Non-Small-Cell	26845350			C34.90	D002289		HP:0030358	MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through down-regulation of BCL6.
tissue_expression_down	hsa-mir-205	Carcinoma, Lung, Non-Small-Cell	21622546			C34.90	D002289		HP:0030358	Eighteen cases were classified as AD and 13 as SCC by light microscopy and immunocytochemistry. miRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens
tissue_expression_down	hsa-mir-21	Carcinoma, Lung, Non-Small-Cell	20363096			C34.90	D002289		HP:0030358	miR-21:Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis
tissue_expression_down	hsa-mir-221	Carcinoma, Lung, Non-Small-Cell	24667259			C34.90	D002289		HP:0030358	Our results indicated that down-regulation of miRNA-221 was associated with poor prognosis of patients with NSCLC. MiRNA-221 may serve as a molecular prognosis marker for patients with NSCLC.
tissue_expression_down	hsa-mir-29	Carcinoma, Lung, Non-Small-Cell	24909176			C34.90	D002289		HP:0030358	the decrease in the expression of miR-29b by c-Myc may be responsible for FHIT loss-mediated tumor aggressiveness and for poor outcome in NSCLC. Therefore, we suggest that restoration of the miR-29b expression using the c-Myc inhibitor might be helpful in suppressing tumor aggressiveness mediated by FHIT loss and consequently improving outcomes in NSCLC patients with tumors with low expression of FHIT.
tissue_expression_down	hsa-mir-30a	Carcinoma, Lung, Non-Small-Cell	21633953			C34.90	D002289		HP:0030358	MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer.
tissue_expression_down	hsa-mir-30a	Carcinoma, Lung, Non-Small-Cell	26238736			C34.90	D002289		HP:0030358	Expression profile analysis of microRNAs and downregulated miR-486-5p and miR-30a-5p in non-small cell lung cancer.
tissue_expression_down	hsa-mir-32	Carcinoma, Lung, Non-Small-Cell	25755781			C34.90	D002289		HP:0030358	Our results provided the first evidence that down-regulation of miR-32 was correlated with NSCLC progression, and miR-32 might be a potential molecular biomarker for predicting the prognosis of patients.
tissue_expression_down	hsa-mir-345	Carcinoma, Lung, Non-Small-Cell	22937028			C34.90	D002289		HP:0030358	High expression of miR-100 and low expression of miRNA-93, miRNA-134, miRNA-151 and miRNA-345 were associated with poor survival in both the training and validation cohort.
tissue_expression_down	hsa-mir-3940	Carcinoma, Lung, Non-Small-Cell	23228962			C34.90	D002289		HP:0030358	Expression of miR-150 and miR-3940-5p is reduced in non-small cell lung carcinoma and correlates with clinicopathological features
tissue_expression_down	hsa-mir-449a	Carcinoma, Lung, Non-Small-Cell	22078727			C34.90	D002289		HP:0030358	miR-449a/b was significantly down-regulated in lung cancer tissues compared with normal lung tissues, while HDAC1 was up-regulated in lung cancer tissues.Combined treatment with miR-449a and HDAC inhibitors (apicidin and TSA) in HCC95 cells showed a significant growth reduction compared to mono-treatment with HDAC inhibitors. Interestingly, combination treatment with TSA and miR-449a was had significant growth reduction than a combination with apicidin.
tissue_expression_down	hsa-mir-449b	Carcinoma, Lung, Non-Small-Cell	22078727			C34.90	D002289		HP:0030358	miR-449a/b was significantly down-regulated in lung cancer tissues compared with normal lung tissues, while HDAC1 was up-regulated in lung cancer tissues.Combined treatment with miR-449a and HDAC inhibitors (apicidin and TSA) in HCC95 cells showed a significant growth reduction compared to mono-treatment with HDAC inhibitors. Interestingly, combination treatment with TSA and miR-449a was had significant growth reduction than a combination with apicidin.
tissue_expression_down	hsa-mir-451a	Carcinoma, Lung, Non-Small-Cell	21875770			C34.90	D002289		HP:0030358	This study showed that miRNA-451 expression decreased in non-small cell lung cancer (NSCLC) tissues and that its expression was negatively associated with lymph node metastasis, the stage of TNM classification and poor prognosis of NSCLC patients. Moreover, significantly different miRNA-451 expression levels were found between smoking and non-smoking patients. The overexpression of miRNA-451 inhibited cell cycle progression, cellular migration and the invasive ability of NSCLC cells.Increased miRNA-451 expression also promoted anoikis of NSCLC cells.
tissue_expression_down	hsa-mir-486	Carcinoma, Lung, Non-Small-Cell	26238736			C34.90	D002289		HP:0030358	Expression profile analysis of microRNAs and downregulated miR-486-5p and miR-30a-5p in non-small cell lung cancer.
tissue_expression_down	hsa-mir-503	Carcinoma, Lung, Non-Small-Cell	26191272			C34.90	D002289		HP:0030358	In patients with NSCLC, low miR-503 expression is an independent prognostic factor.
tissue_expression_down	hsa-mir-93	Carcinoma, Lung, Non-Small-Cell	22937028			C34.90	D002289		HP:0030358	High expression of miR-100 and low expression of miRNA-93, miRNA-134, miRNA-151 and miRNA-345 were associated with poor survival in both the training and validation cohort.
tissue_expression_down	hsa-let-7c	Carcinoma, Lung, Small-Cell	22438992			C34.90	D055752	182280	HP:0030357	Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix.
tissue_expression_down	hsa-mir-100	Carcinoma, Lung, Small-Cell	22438992			C34.90	D055752	182280	HP:0030357	Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix.
tissue_expression_down	hsa-mir-125b-1	Carcinoma, Lung, Small-Cell	22438992			C34.90	D055752	182280	HP:0030357	Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix.
tissue_expression_down	hsa-mir-125b-2	Carcinoma, Lung, Small-Cell	22438992			C34.90	D055752	182280	HP:0030357	Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix.
tissue_expression_down	hsa-mir-137	Carcinoma, Lung, Small-Cell	24412084			C34.90	D055752	182280	HP:0030357	MicroRNA-137 down-regulates KIT and inhibits small cell lung cancer cell proliferation.
tissue_expression_down	hsa-mir-143	Carcinoma, Lung, Small-Cell	22438992			C34.90	D055752	182280	HP:0030357	Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix.
tissue_expression_down	hsa-mir-145	Carcinoma, Lung, Small-Cell	22438992			C34.90	D055752	182280	HP:0030357	Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix.
tissue_expression_down	hsa-mir-199a-1	Carcinoma, Lung, Small-Cell	22438992			C34.90	D055752	182280	HP:0030357	Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix.
tissue_expression_down	hsa-mir-199a-2	Carcinoma, Lung, Small-Cell	22438992			C34.90	D055752	182280	HP:0030357	Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix.
tissue_expression_down	hsa-mir-21	Carcinoma, Lung, Small-Cell	21731696			C34.90	D055752	182280	HP:0030357	The authors observed significantly lower miR-21, miR-29b, and miR-34a expression in SCLC cell lines than in NSCLC cell lines.
tissue_expression_down	hsa-mir-29b-1	Carcinoma, Lung, Small-Cell	21731696			C34.90	D055752	182280	HP:0030357	The authors observed significantly lower miR-21, miR-29b, and miR-34a expression in SCLC cell lines than in NSCLC cell lines.
tissue_expression_down	hsa-mir-29b-2	Carcinoma, Lung, Small-Cell	21731696			C34.90	D055752	182280	HP:0030357	The authors observed significantly lower miR-21, miR-29b, and miR-34a expression in SCLC cell lines than in NSCLC cell lines.
tissue_expression_down	hsa-mir-34a	Carcinoma, Lung, Small-Cell	21731696			C34.90	D055752	182280	HP:0030357	The authors observed significantly lower miR-21, miR-29b, and miR-34a expression in SCLC cell lines than in NSCLC cell lines.
tissue_expression_down	hsa-mir-34a	Carcinoma, Merkel Cell	25491743	disease of cellular proliferation	DOID:3965	C4A.9	D015266		HP:0030447	slight underexpression was detectable in MCV-positive tumors of miR-181d. We confirmed the distinct expression of miRNAs in MCV-positive and MCV-negative tumors and confirmed statistically significant underexpression of miR-34a in MCV-negative tumors by both array analysis and qRT-PCR. Neither tumor location nor development of metastases affected miRNA expression.
tissue_expression_down	hsa-let-7c	Carcinoma, Nasopharyngeal	24751144	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	We found that  let-7c was markedly downregulated in NPC tissues compared to NPs and suppressed cell growth and cell cycle progression by modulating p15/p16/CDK4/E2F1 pathway.
tissue_expression_down	hsa-mir-199b	Carcinoma, Nasopharyngeal	27489139	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	In addition, the low expression levels of hsa-miR-4324, hsa-miR-203a and hsa-miR-199b-5p were further validated in stage I NPC by ISH.
tissue_expression_down	hsa-mir-203a	Carcinoma, Nasopharyngeal	27489139	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	In addition, the low expression levels of hsa-miR-4324, hsa-miR-203a and hsa-miR-199b-5p were further validated in stage I NPC by ISH.
tissue_expression_down	hsa-mir-21	Carcinoma, Nasopharyngeal	25031780	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	miR-21 inhibitor suppresses proliferation and migration of nasopharyngeal carcinoma cells through down-regulation of BCL2 expression.
tissue_expression_down	hsa-mir-23a	Carcinoma, Nasopharyngeal	24498188	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	We identified fifteen differential miRNAs and 372 differential mRNAs in the radioresistant NPC cells, constructed a posttranscriptional regulatory network including 375 miRNA-target gene pairs, discovered the ten target genes coregulated by the six miRNAs, and validated that downregulated miRNA-23a was involved in NPC radioresistance through directly targeting IL-8. Our data form a basis for further investigating the mechanisms of NPC radioresistance.
tissue_expression_down	hsa-mir-24	Carcinoma, Nasopharyngeal	27157611	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	miR-24 levels were significantly decreased in recurrent NPC
tissue_expression_down	hsa-mir-372	Carcinoma, Nasopharyngeal	25265349	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	This preliminary study indicated the tumor suppressing roles of miR-372 in cell cycle progression of TW01 cells, possibly via the down-regulation of CDK2 and CCNA1 as well as the up-regulation of CDKN1A and INCA1.Key Words: apoptosis, microRNA, nasopharyngeal carcinoma, miR-372, CDK2, CCNA1.
tissue_expression_down	hsa-mir-4324	Carcinoma, Nasopharyngeal	27489139	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	In addition, the low expression levels of hsa-miR-4324, hsa-miR-203a and hsa-miR-199b-5p were further validated in stage I NPC by ISH.
tissue_expression_down	hsa-mir-504	Carcinoma, Nasopharyngeal	26201446	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	miR-504 mediated down-regulation of nuclear respiratory factor 1 leads to radio-resistance in nasopharyngeal carcinoma.
tissue_expression_down	hsa-let-7b	Carcinoma, Oral	20232482	gastrointestinal system disease	DOID:0050610					Together, these data demonstrate that elevated expression levels of Dicer in oral cancer cells correlate with downregulation of let-7b and  increased cell proliferation.
tissue_expression_down	hsa-mir-203	Carcinoma, Oral	25910964	gastrointestinal system disease	DOID:0050610					miR-203 downregulates Yes-1 and suppresses oncogenic activity in human oral cancer cells.
tissue_expression_down	hsa-mir-99a	Carcinoma, Oral	22751686	gastrointestinal system disease	DOID:0050610					Downregulation of microRNA 99a in oral squamous cell carcinomas contributes to the growth and survival of oral cancer cells.
tissue_expression_down	hsa-mir-211	Carcinoma, Ovarian	25889927	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	Our results demonstrate that miR-211 is a tumor suppressor that controls expression of Cyclin D1 and CDK6, and that its downregulation results in overexpression of Cyclin D1 and CDK6 which increases proliferation ability of EOC cells to proliferate compared to normal cells.
tissue_expression_down	hsa-mir-22	Carcinoma, Ovarian	25257702	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	Our data demonstrated that the expression of miR-22 was downregulated in EOC, and associated with overall survival as well as progression-free survival, suggesting that miR-22 could serve as an efficient prognostic factor for EOC patients.
tissue_expression_down	hsa-mir-29a	Carcinoma, Ovarian	25556270	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	In SOC tissue, expression of miR-200a, miR-93, miR-146a, and miR-18a were up-regulated, while miR-145, miR-143, miR-29a were down-regulated.
tissue_expression_down	hsa-mir-630	Carcinoma, Ovarian	26345808	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	In conclusion, downregulation of miR-630 dramatically increased apoptotic cell death chemosensitivity to cisplatin and decreased the proliferation, invasion, and migration of EOC cells. MiR-630 may thus play an important role in the biological behaviors of EOC cells through negative control of the PTEN expression.
tissue_expression_down	hsa-mir-449	Carcinoma, Ovarian, Clear Cell	25238166	endocrine system disease	DOID:0050934					Low expression of miR-449 in gynecologic clear cell carcinoma.
tissue_expression_down	hsa-mir-127	Carcinoma, Pancreatic	27571739			C25.3	C562463	260350	HP:0002894	MicroRNA-127 is aberrantly downregulated and acted as a functional tumor suppressor in human pancreatic cancer.
tissue_expression_down	hsa-mir-15a	Carcinoma, Pancreatic	18665421			C25.3	C562463	260350	HP:0002894	In addition, when analyzed according to specific cancer phenotypes, miR-15a and miR-16 show a significant downregulation in canine ductal carcinomas while miRsR-181b, -21, -29b, and let-7f show a significant upregulation in canine tubular papillary carcinomas.
tissue_expression_down	hsa-mir-16	Carcinoma, Pancreatic	18665421			C25.3	C562463	260350	HP:0002894	In addition, when analyzed according to specific cancer phenotypes, miR-15a and miR-16 show a significant downregulation in canine ductal carcinomas while miRsR-181b, -21, -29b, and let-7f show a significant upregulation in canine tubular papillary carcinomas.
tissue_expression_down	hsa-mir-149	Carcinoma, Prostate	27573045	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	Downregulated expression of miRNA-149 promotes apoptosis in side population cells sorted from the TSU prostate cancer cell line.
tissue_expression_down	hsa-mir-185	Carcinoma, Prostate	25673182	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	MicroRNA-185 downregulates androgen receptor expression in the LNCaP prostate carcinoma cell line.
tissue_expression_down	hsa-mir-125a	Carcinoma, Rectal	21671476	disease of cellular proliferation	DOID:1993	C20	D012004			One of the most up-regulated miRNAs, miRNA-106a, was consistently reported to be differentially expressed in six studies and the five most down-regulated miRNAs, miR-30a-3p, miR-139, miR-145, miR-125a and miR-133a, were consistently reported to be differentially expressed in four studies.
tissue_expression_down	hsa-mir-133a	Carcinoma, Rectal	21671476	disease of cellular proliferation	DOID:1993	C20	D012004			One of the most up-regulated miRNAs, miRNA-106a, was consistently reported to be differentially expressed in six studies and the five most down-regulated miRNAs, miR-30a-3p, miR-139, miR-145, miR-125a and miR-133a, were consistently reported to be differentially expressed in four studies.
tissue_expression_down	hsa-mir-135a	Carcinoma, Rectal	20955366	disease of cellular proliferation	DOID:1993	C20	D012004			The miR-135a&b were the miRNAs most down-regulated by CM-1.
tissue_expression_down	hsa-mir-135b	Carcinoma, Rectal	20955366	disease of cellular proliferation	DOID:1993	C20	D012004			The miR-135a&b were the miRNAs most down-regulated by CM-1.
tissue_expression_down	hsa-mir-139	Carcinoma, Rectal	21671476	disease of cellular proliferation	DOID:1993	C20	D012004			One of the most up-regulated miRNAs, miRNA-106a, was consistently reported to be differentially expressed in six studies and the five most down-regulated miRNAs, miR-30a-3p, miR-139, miR-145, miR-125a and miR-133a, were consistently reported to be differentially expressed in four studies.
tissue_expression_down	hsa-mir-143	Carcinoma, Rectal	18196926	disease of cellular proliferation	DOID:1993	C20	D012004			Expression levels of analyzed miRNAs significantly differed among tumors and adjacent non-tumor tissues: miR-21 (p = 0.0001) and miR-31 (p = 0.0006) were upregulated, and miR-143 (p = 0.011) and miR-145 (p = 0.003) were downregulated in tumors.
tissue_expression_down	hsa-mir-145	Carcinoma, Rectal	18196926	disease of cellular proliferation	DOID:1993	C20	D012004			Expression levels of analyzed miRNAs significantly differed among tumors and adjacent non-tumor tissues: miR-21 (p = 0.0001) and miR-31 (p = 0.0006) were upregulated, and miR-143 (p = 0.011) and miR-145 (p = 0.003) were downregulated in tumors.
tissue_expression_down	hsa-mir-145	Carcinoma, Rectal	21671476	disease of cellular proliferation	DOID:1993	C20	D012004			One of the most up-regulated miRNAs, miRNA-106a, was consistently reported to be differentially expressed in six studies and the five most down-regulated miRNAs, miR-30a-3p, miR-139, miR-145, miR-125a and miR-133a, were consistently reported to be differentially expressed in four studies.
tissue_expression_down	hsa-mir-30a	Carcinoma, Rectal	21671476	disease of cellular proliferation	DOID:1993	C20	D012004			One of the most up-regulated miRNAs, miRNA-106a, was consistently reported to be differentially expressed in six studies and the five most down-regulated miRNAs, miR-30a-3p, miR-139, miR-145, miR-125a and miR-133a, were consistently reported to be differentially expressed in four studies.
tissue_expression_down	hsa-let-7b	Carcinoma, Renal Cell	25951903	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Expression of let-7b and let-7c was significantly decreased in 32 paired clear cell renal cell carcinoma tissue specimens
tissue_expression_down	hsa-let-7c	Carcinoma, Renal Cell	25951903	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Expression of let-7b and let-7c was significantly decreased in 32 paired clear cell renal cell carcinoma tissue specimens
tissue_expression_down	hsa-mir-1	Carcinoma, Renal Cell	21745735	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Our data indicate that up-regulation of the oncogenic TAGLN2 was due to down-regulation of tumour-suppressive miR-1 and miR-133a in human RCC.
tissue_expression_down	hsa-mir-106b	Carcinoma, Renal Cell	20609231	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miRNA-106b:Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy
tissue_expression_down	hsa-mir-10b	Carcinoma, Renal Cell	22492545	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Expression levels of miR-143, miR-26a, miR-145, miR-10b, miR-195, and miR-126 are lower in the tumors of RCC patients who developed tumor relapse.
tissue_expression_down	hsa-mir-126	Carcinoma, Renal Cell	22492545	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Expression levels of miR-143, miR-26a, miR-145, miR-10b, miR-195, and miR-126 are lower in the tumors of RCC patients who developed tumor relapse.
tissue_expression_down	hsa-mir-133a	Carcinoma, Renal Cell	21745735	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Our data indicate that up-regulation of the oncogenic TAGLN2 was due to down-regulation of tumour-suppressive miR-1 and miR-133a in human RCC.
tissue_expression_down	hsa-mir-133b	Carcinoma, Renal Cell	24714873	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	microRNA-133b downregulation and inhibition of cell proliferation, migration and  invasion by targeting matrix metallopeptidase-9 in renal cell carcinoma.
tissue_expression_down	hsa-mir-141	Carcinoma, Renal Cell	19228262	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-141: down-regulated in malignant cancer than non-malignant one
tissue_expression_down	hsa-mir-141	Carcinoma, Renal Cell	23206420	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	A possible role for micro-RNA 141 down-regulation in sunitinib resistant metastatic clear cell renal cell carcinoma through induction of epithelial-to-mesenchymal transition and hypoxia resistance
tissue_expression_down	hsa-mir-143	Carcinoma, Renal Cell	22492545	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Expression levels of miR-143, miR-26a, miR-145, miR-10b, miR-195, and miR-126 are lower in the tumors of RCC patients who developed tumor relapse.
tissue_expression_down	hsa-mir-145	Carcinoma, Renal Cell	22492545	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Expression levels of miR-143, miR-26a, miR-145, miR-10b, miR-195, and miR-126 are lower in the tumors of RCC patients who developed tumor relapse.
tissue_expression_down	hsa-mir-149	Carcinoma, Renal Cell	24137408	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-141, miR-149 and miR-429 were downregulated in the ccRCC tissues
tissue_expression_down	hsa-mir-192	Carcinoma, Renal Cell	29440068	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-192 and miR-194 as downregulated
tissue_expression_down	hsa-mir-194	Carcinoma, Renal Cell	29440068	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-192 and miR-194 as downregulated
tissue_expression_down	hsa-mir-195	Carcinoma, Renal Cell	22492545	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Expression levels of miR-143, miR-26a, miR-145, miR-10b, miR-195, and miR-126 are lower in the tumors of RCC patients who developed tumor relapse.
tissue_expression_down	hsa-mir-199a-1	Carcinoma, Renal Cell	23174576	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	A decreased expression of miR-199a is significantly correlated with a higher tumor stage, a greater likeliness of tumor recurrence, and a poorer prognosis in RCC patients
tissue_expression_down	hsa-mir-199a-2	Carcinoma, Renal Cell	23174576	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	A decreased expression of miR-199a is significantly correlated with a higher tumor stage, a greater likeliness of tumor recurrence, and a poorer prognosis in RCC patients
tissue_expression_down	hsa-mir-200b	Carcinoma, Renal Cell	19228262	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-200b: down-regulated in malignant cancer than non-malignant one
tissue_expression_down	hsa-mir-200c	Carcinoma, Renal Cell	19228262	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-200c: down-regulated in malignant cancer than non-malignant one
tissue_expression_down	hsa-mir-200c	Carcinoma, Renal Cell	21784468	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Underexpression
tissue_expression_down	hsa-mir-21	Carcinoma, Renal Cell	24902663	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	MiR-21 not only promoted cancer cell hyperplasia and contributed to tumor cell transformation and metastasis, but also post-transcriptionally downregulated PDCD4 protein expression. PDCD4 and miR-21 expression levels potentially play an important role in renal cell cancer.
tissue_expression_down	hsa-mir-218-1	Carcinoma, Renal Cell	21784468	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Underexpression
tissue_expression_down	hsa-mir-218-2	Carcinoma, Renal Cell	21784468	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Underexpression
tissue_expression_down	hsa-mir-26a-1	Carcinoma, Renal Cell	22492545	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Expression levels of miR-143, miR-26a, miR-145, miR-10b, miR-195, and miR-126 are lower in the tumors of RCC patients who developed tumor relapse.
tissue_expression_down	hsa-mir-26a-2	Carcinoma, Renal Cell	22492545	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Expression levels of miR-143, miR-26a, miR-145, miR-10b, miR-195, and miR-126 are lower in the tumors of RCC patients who developed tumor relapse.
tissue_expression_down	hsa-mir-30c	Carcinoma, Renal Cell	24112779	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	hypoxia induces EMT in RCC cells through downregulation of miR-30c, which leads to subsequent increase of Slug expression and repression of E-cadherin production, and suggest a potential application of miR-30c in RCC treatment.
tissue_expression_down	hsa-mir-335	Carcinoma, Renal Cell	21784468	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Underexpression
tissue_expression_down	hsa-mir-363	Carcinoma, Renal Cell	19228262	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-363: down-regulated in malignant cancer than non-malignant one
tissue_expression_down	hsa-mir-429	Carcinoma, Renal Cell	19228262	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-429: down-regulated in malignant cancer than non-malignant one
tissue_expression_down	hsa-mir-510	Carcinoma, Renal Cell	25936999	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Downregulated microRNA-510-5p acts as a tumor suppressor in renal cell carcinoma.
tissue_expression_down	hsa-mir-514a-1	Carcinoma, Renal Cell	19228262	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-514: down-regulated in malignant cancer than non-malignant one
tissue_expression_down	hsa-mir-514a-2	Carcinoma, Renal Cell	19228262	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-514: down-regulated in malignant cancer than non-malignant one
tissue_expression_down	hsa-mir-514a-3	Carcinoma, Renal Cell	19228262	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-514: down-regulated in malignant cancer than non-malignant one
tissue_expression_down	hsa-mir-187	Carcinoma, Renal Cell, Clear-Cell	23916610	disease of cellular proliferation	DOID:4467				HP:0006770	MicroRNA-187, down-regulated in clear cell renal cell carcinoma and associated with lower survival, inhibits cell growth and migration though targeting B7-H3.
tissue_expression_down	hsa-mir-125b	Carcinoma, Thyroid, Anaplastic	17563749			C73	D065646	188550	HP:0011779	The overexpression of these four miRs in two human ATC-derived cell lines suggests a critical role of miR-125b and miR-26a downregulation in thyroid carcinogenesis, since a cell growth inhibition was achieved.
tissue_expression_down	hsa-mir-26a	Carcinoma, Thyroid, Anaplastic	17563749			C73	D065646	188550	HP:0011779	The overexpression of these four miRs in two human ATC-derived cell lines suggests a critical role of miR-125b and miR-26a downregulation in thyroid carcinogenesis, since a cell growth inhibition was achieved.
tissue_expression_down	hsa-mir-138	Carcinoma, Thyroid, Papillary	26380656	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	miR-138 and miR-98 were down-regulated in tumors compared to normal tissues.
tissue_expression_down	hsa-mir-221	Carcinoma, Thyroid, Papillary	27162538	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	postoperative levels of miR-151-5p, miR-221 and miR-222 were significantly lower in patients with PTC.
tissue_expression_down	hsa-mir-222	Carcinoma, Thyroid, Papillary	27162538	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	postoperative levels of miR-151-5p, miR-221 and miR-222 were significantly lower in patients with PTC.
tissue_expression_down	hsa-mir-30c-2	Carcinoma, Thyroid, Papillary	26487287	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Our results showed that down-regulated microRNAs can be used as new potential common biomarkers of PTC and to distinguish main subtypes of PTC.MicroRNA expressions can be linked to the development of LNM of PTC. The bioinformatics framework that we have developed can be used as a starting point for the global analysis of any microRNA deep-sequencing data in an unbiased way.
tissue_expression_down	hsa-mir-7-2	Carcinoma, Thyroid, Papillary	26487287	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Our results showed that down-regulated microRNAs can be used as new potential common biomarkers of PTC and to distinguish main subtypes of PTC.MicroRNA expressions can be linked to the development of LNM of PTC. The bioinformatics framework that we have developed can be used as a starting point for the global analysis of any microRNA deep-sequencing data in an unbiased way.
tissue_expression_down	hsa-mir-133a	Cardiac Fibrosis	26371176							The results reveal that HDACs play a role in the regulation of pressure overload-induced miR-133a downregulation. This work is the first to provide insight into an epigenetic-miRNA regulatory pathway in pressure overload-induced cardiac fibrosis.
tissue_expression_down	hsa-mir-1	Cardiomegaly	26675618			I51.7	D006332		HP:0001640	mature miR-1 levels decrease with pressure-induced cardiac hypertrophy
tissue_expression_down	hsa-mir-448	Cardiomyopathy	26503985	cardiovascular system disease	DOID:0050700	I42	D009202			Our studies suggest that downregulation of miR-448-3p leads to the increase in the expression of Ncf1 gene and p47(phox) protein, as well as to the substantial increase in NOX2-derived ROS production. Cellular oxidative stress subsequently triggers events that finally culminate in cardiac tissue damage and development of cardiomyopathy.
tissue_expression_down	hsa-let-7i	Cardiomyopathy, Dilated	22041329	cardiovascular system disease	DOID:12930	I42.0	D002311	115200	HP:0001644	Levels of let-7i, miR-126, and miR-155 were lower in the DCM group than in the controls, whereas levels of miR-21 and TLR4 (both mRNA and protein) were higher in the DCM group than in the control group. Levels of let-7i were negatively correlated with TLR4 protein levels in all subjects. After a mean follow-up period of 509 days, 6 DCM patients (5.8%) had died due to a cardiac cause and 15 (14.6%) had developed heart failure. When patients with DCM were divided into tertiles according to let-7i levels, log-rank analysis showed that the DCM subgroup with low let-7i levels was associated with poor clinical outcomes (P = .02).
tissue_expression_down	hsa-mir-126	Cardiomyopathy, Dilated	22041329	cardiovascular system disease	DOID:12930	I42.0	D002311	115200	HP:0001644	Levels of let-7i, miR-126, and miR-155 were lower in the DCM group than in the controls, whereas levels of miR-21 and TLR4 (both mRNA and protein) were higher in the DCM group than in the control group. Levels of let-7i were negatively correlated with TLR4 protein levels in all subjects. After a mean follow-up period of 509 days, 6 DCM patients (5.8%) had died due to a cardiac cause and 15 (14.6%) had developed heart failure. When patients with DCM were divided into tertiles according to let-7i levels, log-rank analysis showed that the DCM subgroup with low let-7i levels was associated with poor clinical outcomes (P = .02).
tissue_expression_down	hsa-mir-155	Cardiomyopathy, Dilated	22041329	cardiovascular system disease	DOID:12930	I42.0	D002311	115200	HP:0001644	Levels of let-7i, miR-126, and miR-155 were lower in the DCM group than in the controls, whereas levels of miR-21 and TLR4 (both mRNA and protein) were higher in the DCM group than in the control group. Levels of let-7i were negatively correlated with TLR4 protein levels in all subjects. After a mean follow-up period of 509 days, 6 DCM patients (5.8%) had died due to a cardiac cause and 15 (14.6%) had developed heart failure. When patients with DCM were divided into tertiles according to let-7i levels, log-rank analysis showed that the DCM subgroup with low let-7i levels was associated with poor clinical outcomes (P = .02).
tissue_expression_down	hsa-mir-150	Cardiomyopathy, Hypertrophic	17108080	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	downregulated
tissue_expression_down	hsa-mir-181b-1	Cardiomyopathy, Hypertrophic	17108080	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	downregulated
tissue_expression_down	hsa-mir-181b-2	Cardiomyopathy, Hypertrophic	17108080	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	downregulated
tissue_expression_down	hsa-mir-1303	Cardiotoxicity	26842497				D066126			early deregulation of miR-187-3p, miR-182-5p, miR-486-3p, miR-486-5p, miR-34a-3p, miR-4423-3p, miR-34c-3p, miR-34c-5p and miR-1303, and also the prolonged up-regulation of miR-182-5p, miR-4423-3p and miR-34c-5p.
tissue_expression_down	hsa-mir-182	Cardiotoxicity	26842497				D066126			early deregulation of miR-187-3p, miR-182-5p, miR-486-3p, miR-486-5p, miR-34a-3p, miR-4423-3p, miR-34c-3p, miR-34c-5p and miR-1303, and also the prolonged up-regulation of miR-182-5p, miR-4423-3p and miR-34c-5p.
tissue_expression_down	hsa-mir-187	Cardiotoxicity	26842497				D066126			early deregulation of miR-187-3p, miR-182-5p, miR-486-3p, miR-486-5p, miR-34a-3p, miR-4423-3p, miR-34c-3p, miR-34c-5p and miR-1303, and also the prolonged up-regulation of miR-182-5p, miR-4423-3p and miR-34c-5p.
tissue_expression_down	hsa-mir-34a	Cardiotoxicity	26842497				D066126			early deregulation of miR-187-3p, miR-182-5p, miR-486-3p, miR-486-5p, miR-34a-3p, miR-4423-3p, miR-34c-3p, miR-34c-5p and miR-1303, and also the prolonged up-regulation of miR-182-5p, miR-4423-3p and miR-34c-5p.
tissue_expression_down	hsa-mir-34c	Cardiotoxicity	26842497				D066126			early deregulation of miR-187-3p, miR-182-5p, miR-486-3p, miR-486-5p, miR-34a-3p, miR-4423-3p, miR-34c-3p, miR-34c-5p and miR-1303, and also the prolonged up-regulation of miR-182-5p, miR-4423-3p and miR-34c-5p.
tissue_expression_down	hsa-mir-486	Cardiotoxicity	26842497				D066126			early deregulation of miR-187-3p, miR-182-5p, miR-486-3p, miR-486-5p, miR-34a-3p, miR-4423-3p, miR-34c-3p, miR-34c-5p and miR-1303, and also the prolonged up-regulation of miR-182-5p, miR-4423-3p and miR-34c-5p.
tissue_expression_down	hsa-mir-133a-1	Cardiovascular Diseases [unspecific]	20173049				D002318			miR-133a:NFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repression
tissue_expression_down	hsa-mir-487b	Cardiovascular Diseases [unspecific]	24096771				D002318			Angiotensin II-induced hypertension leads to upregulation of miR-487b, which targets IRS1. Via downregulation of IRS1, miR-487b can contribute to cell death and loss of adventitial and medial integrity during hypertension-induced vascular pathology.
tissue_expression_down	hsa-let-7b	Cerebral Cavernous Malformations	28181149	disease of cellular proliferation	DOID:0060669	Q28.3	C566394	116860		Genome-Wide Sequencing Reveals MicroRNAs Downregulated in Cerebral Cavernous Malformations.
tissue_expression_down	hsa-mir-181a	Cerebral Cavernous Malformations	28181149	disease of cellular proliferation	DOID:0060669	Q28.3	C566394	116860		Genome-Wide Sequencing Reveals MicroRNAs Downregulated in Cerebral Cavernous Malformations.
tissue_expression_down	hsa-mir-361	Cerebral Cavernous Malformations	28181149	disease of cellular proliferation	DOID:0060669	Q28.3	C566394	116860		Genome-Wide Sequencing Reveals MicroRNAs Downregulated in Cerebral Cavernous Malformations.
tissue_expression_down	hsa-mir-370	Cerebral Cavernous Malformations	28181149	disease of cellular proliferation	DOID:0060669	Q28.3	C566394	116860		Genome-Wide Sequencing Reveals MicroRNAs Downregulated in Cerebral Cavernous Malformations.
tissue_expression_down	hsa-mir-95	Cerebral Cavernous Malformations	28181149	disease of cellular proliferation	DOID:0060669	Q28.3	C566394	116860		Genome-Wide Sequencing Reveals MicroRNAs Downregulated in Cerebral Cavernous Malformations.
tissue_expression_down	hsa-mir-143	Cervical Neoplasms	27278606	disease of cellular proliferation	DOID:4362	C53.9	D002583	603956	HP:0030159	expression of miR-21 was upregulated and the expression of miR-143 was downregulated by the HPV16 E7 oncoprotein in vivo
tissue_expression_down	hsa-mir-143	Cervical Neoplasms	22997891	disease of cellular proliferation	DOID:4362	C53.9	D002583	603956	HP:0030159	The high expression of miR-21 in cervical cancer and Hela cell indicate that it may play a possible role of oncogenes, while miR-143 and miR-373 with low expression may play the role of tumor suppressor genes.
tissue_expression_down	hsa-mir-145	Cervical Neoplasms	27345415	disease of cellular proliferation	DOID:4362	C53.9	D002583	603956	HP:0030159	miRNA-145 and 9 may be as potential prognostic marker in patients suffering from cervical cancer.
tissue_expression_down	hsa-mir-34a	Cervical Neoplasms	29487007	disease of cellular proliferation	DOID:4362	C53.9	D002583	603956	HP:0030159	MiR-21-5p upregulation, miR-34a downregulation, and hTERC amplification were associated with the aggressive progression of CC, which suggests that miR-21-5p, miR-34a and hTERC might serve as surrogate markers for CC progression and potential molecular targets for blockage of the development of CC
tissue_expression_down	hsa-mir-34a	Cervical Neoplasms	20442590	disease of cellular proliferation	DOID:4362	C53.9	D002583	603956	HP:0030159	Reduced miR-34a expression in normal cervical tissues and cervical lesions with high-risk human papillomavirus infection.
tissue_expression_down	hsa-mir-373	Cervical Neoplasms	22997891	disease of cellular proliferation	DOID:4362	C53.9	D002583	603956	HP:0030159	The high expression of miR-21 in cervical cancer and Hela cell indicate that it may play a possible role of oncogenes, while miR-143 and miR-373 with low expression may play the role of tumor suppressor genes.
tissue_expression_down	hsa-mir-200a	Cholangiocarcinoma	26586458	disease of cellular proliferation	DOID:4947	C22.1	D018281	615619	HP:0030153	MiR-200a may suppress the proliferative and invasive ability of REB cells. The reduced miR-200a expression might be correlated with the development and progression of CCA.
tissue_expression_down	hsa-mir-494	Cholangiocarcinoma	21809359	disease of cellular proliferation	DOID:4947	C22.1	D018281	615619	HP:0030153	miRNA-494 downregulated in human cholangiocarcinoma controls cell cycle through multiple targets involved in the G1/S checkpoint.
tissue_expression_down	hsa-mir-200b	Chondrosarcoma	25301739	disease of cellular proliferation	DOID:3371	M91-M94	D002813	215300	HP:0006765	CCL5 promotes VEGF-dependent angiogenesis by down-regulating miR-200b through PI3K/Akt signaling pathway in human chondrosarcoma cells.
tissue_expression_down	hsa-mir-106a	Choriocarcinoma	27080237	disease of cellular proliferation	DOID:3594	C58	D002822		HP:0100768	low miR-106a expression was associated with hepatitis B virus infection in hepatocellular carcinoma.
tissue_expression_down	hsa-mir-155	Choriocarcinoma	24007214	disease of cellular proliferation	DOID:3594	C58	D002822		HP:0100768	There were low expressions of exosomal miR-155 and miR-196a in serum samples of PC patients when U-6 was used as a control. Serum exosomal miR-17-5p was higher in PC patients than in non-PC patients and healthy participants.
tissue_expression_down	hsa-mir-196a	Choriocarcinoma	24007214	disease of cellular proliferation	DOID:3594	C58	D002822		HP:0100768	There were low expressions of exosomal miR-155 and miR-196a in serum samples of PC patients when U-6 was used as a control. Serum exosomal miR-17-5p was higher in PC patients than in non-PC patients and healthy participants.
tissue_expression_down	hsa-mir-200b	Choriocarcinoma	27189341	disease of cellular proliferation	DOID:3594	C58	D002822		HP:0100768	carcinomas exhibiting lymph vessel invasion had significantly lower expression of miR-200a (P=.0230) and miR-200b (P=.0168)
tissue_expression_down	hsa-mir-34a	Choriocarcinoma	20351093	disease of cellular proliferation	DOID:3594	C58	D002822		HP:0100768	MicroRNA-34a suppresses invasion through down-regulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells
tissue_expression_down	hsa-mir-195	Chronic Heart Failure	20845893	cardiovascular system disease	DOID:6000	I50	D006333		HP:0001635	miR-195:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI.
tissue_expression_down	hsa-mir-26a-1	Chronic Heart Failure	20845893	cardiovascular system disease	DOID:6000	I50	D006333		HP:0001635	MiR-26a:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI.
tissue_expression_down	hsa-mir-26a-2	Chronic Heart Failure	20845893	cardiovascular system disease	DOID:6000	I50	D006333		HP:0001635	MiR-26a:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI.
tissue_expression_down	hsa-mir-30b	Chronic Heart Failure	20845893	cardiovascular system disease	DOID:6000	I50	D006333		HP:0001635	MiR-30b:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI.
tissue_expression_down	hsa-mir-106a	Chronic Hepatitis B	26265888			B18.0-.1	D019694	610424		This study suggested that miR-106a is downregulated in PBMCs of CHB patients and that miR-106a may play an important role in CHB by targeting IL-8.
tissue_expression_down	hsa-mir-130a	Chronic Hepatitis C	23418453			B18.2	D019698	609532		Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-α treatment (p<0.01)
tissue_expression_down	hsa-mir-192	Chronic Hepatitis C	23418453			B18.2	D019698	609532		Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-α treatment (p<0.01)
tissue_expression_down	hsa-mir-199a	Chronic Hepatitis C	27275163			B18.2	D019698	609532		17 miRNAs (including miR-21, miR-122, miR-199a-3p, and miR-223) showed down-regulation.
tissue_expression_down	hsa-mir-301	Chronic Hepatitis C	23418453			B18.2	D019698	609532		Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-α treatment (p<0.01)
tissue_expression_down	hsa-mir-30b	Chronic Hepatitis C	23418453			B18.2	D019698	609532		Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-α treatment (p<0.01)
tissue_expression_down	hsa-mir-30c	Chronic Hepatitis C	23418453			B18.2	D019698	609532		Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-α treatment (p<0.01)
tissue_expression_down	hsa-mir-324	Chronic Hepatitis C	23418453			B18.2	D019698	609532		Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-α treatment (p<0.01)
tissue_expression_down	hsa-mir-565	Chronic Hepatitis C	23418453			B18.2	D019698	609532		Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-α treatment (p<0.01)
tissue_expression_down	hsa-let-7e	Chronic Inflammation	27539004							PM2.5 decreased expression of miR-338-5p and let-7e-5p, both related to mental development
tissue_expression_down	hsa-mir-338	Chronic Inflammation	27539004							PM2.5 decreased expression of miR-338-5p and let-7e-5p, both related to mental development
tissue_expression_down	hsa-mir-92b	Chronic Inflammation	27539004							miR-99b-5p, miR-92b-5p, and miR-99a-5p were decreased, leading to reduced expression of Kbtbd8 and Adam11 which reduced cell mitosis, migration, and differentiation, and inhibited learning abilities and motor coordination of the fetus
tissue_expression_down	hsa-mir-99a	Chronic Inflammation	27539004							miR-99b-5p, miR-92b-5p, and miR-99a-5p were decreased, leading to reduced expression of Kbtbd8 and Adam11 which reduced cell mitosis, migration, and differentiation, and inhibited learning abilities and motor coordination of the fetus
tissue_expression_down	hsa-mir-99b	Chronic Inflammation	27539004							miR-99b-5p, miR-92b-5p, and miR-99a-5p were decreased, leading to reduced expression of Kbtbd8 and Adam11 which reduced cell mitosis, migration, and differentiation, and inhibited learning abilities and motor coordination of the fetus
tissue_expression_down	hsa-mir-133a	Chronic Kidney Disease	27419135	urinary system disease	DOID:784	N18.9	D007676		HP:0012622	miR-30b, -133a, and -143 were downregulated during the  time course of Pi-induced VC, whereas the addition of Mg(2+) restored (miR-30b) or improved (miR-133a, miR-143) their expression.
tissue_expression_down	hsa-mir-143	Chronic Kidney Disease	27419135	urinary system disease	DOID:784	N18.9	D007676		HP:0012622	miR-30b, -133a, and -143 were downregulated during the  time course of Pi-induced VC, whereas the addition of Mg(2+) restored (miR-30b) or improved (miR-133a, miR-143) their expression.
tissue_expression_down	hsa-mir-15	Chronic Kidney Disease	28771472	urinary system disease	DOID:784	N18.9	D007676		HP:0012622	MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension.
tissue_expression_down	hsa-mir-17	Chronic Kidney Disease	28771472	urinary system disease	DOID:784	N18.9	D007676		HP:0012622	MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension.
tissue_expression_down	hsa-mir-204	Chronic Kidney Disease	26707063	urinary system disease	DOID:784	N18.9	D007676		HP:0012622	miR-30d, miR-140-3p, miR-532-3p, miR-194, miR-190, miR-204 and miR-206 were downregulated in progressive cases.
tissue_expression_down	hsa-mir-100	Chronic Obstructive Pulmonary Disease	22686440	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	There was down-regulation of miR-20a, miR-28-3p, miR-34c-5p, and miR-100, and up-regulation of miR-7, compared with the controls.
tissue_expression_down	hsa-mir-20a	Chronic Obstructive Pulmonary Disease	22686440	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	There was down-regulation of miR-20a, miR-28-3p, miR-34c-5p, and miR-100, and up-regulation of miR-7, compared with the controls.
tissue_expression_down	hsa-mir-28	Chronic Obstructive Pulmonary Disease	22686440	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	There was down-regulation of miR-20a, miR-28-3p, miR-34c-5p, and miR-100, and up-regulation of miR-7, compared with the controls.
tissue_expression_down	hsa-mir-34c	Chronic Obstructive Pulmonary Disease	22686440	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	There was down-regulation of miR-20a, miR-28-3p, miR-34c-5p, and miR-100, and up-regulation of miR-7, compared with the controls.
tissue_expression_down	hsa-mir-7-1	Chronic Obstructive Pulmonary Disease	22686440	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	There was down-regulation of miR-20a, miR-28-3p, miR-34c-5p, and miR-100, and up-regulation of miR-7, compared with the controls.
tissue_expression_down	hsa-mir-7-2	Chronic Obstructive Pulmonary Disease	22686440	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	There was down-regulation of miR-20a, miR-28-3p, miR-34c-5p, and miR-100, and up-regulation of miR-7, compared with the controls.
tissue_expression_down	hsa-mir-7-3	Chronic Obstructive Pulmonary Disease	22686440	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	There was down-regulation of miR-20a, miR-28-3p, miR-34c-5p, and miR-100, and up-regulation of miR-7, compared with the controls.
tissue_expression_down	hsa-mir-429	Colitis	26818658	gastrointestinal system disease	DOID:0060180	K52.9	D003092	191390	HP:0002583	We investigated  MIR429 that is down-regulated in DSS-induced colitis, and identified 41 target genes of MIR429.
tissue_expression_down	hsa-mir-143	Colitis, Ulcerative	21557394	gastrointestinal system disease	DOID:8577	K51	D003093			miR-143 and miR-145 are downregulated in ulcerative colitis
tissue_expression_down	hsa-mir-145	Colitis, Ulcerative	21557394	gastrointestinal system disease	DOID:8577	K51	D003093			miR-143 and miR-145 are downregulated in ulcerative colitis
tissue_expression_down	hsa-mir-26b	Colitis, Ulcerative	26083618	gastrointestinal system disease	DOID:8577	K51	D003093			We suggest that miR-26b could serve as a biomarker for inflammation-associated processes in the gastrointestinal system. Because miR-26b expression is downregulated in sporadic colon cancer, it could discriminate between UCC and the sporadic cancer type.
tissue_expression_down	hsa-mir-1231	Colon Neoplasms	22180714			D12.6	D003110		HP:0100273	Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc.
tissue_expression_down	hsa-mir-126	Colon Neoplasms	20859756			D12.6	D003110		HP:0100273	miR-126:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection.
tissue_expression_down	hsa-mir-127	Colon Neoplasms	26556872			D12.6	D003110		HP:0100273	highly up-regulated miRNAs, let-7f-5p, miR-455-3p, miR-98, miR-155-5p and the down-regulated miRNAs, miR-1, miR-127-5p, miR-142-5p, miR-202-5p were associated with colon cancer pathways
tissue_expression_down	hsa-mir-133b	Colon Neoplasms	19946373			D12.6	D003110		HP:0100273	downregulated
tissue_expression_down	hsa-mir-142	Colon Neoplasms	20859756			D12.6	D003110		HP:0100273	miR-142-3p:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection.
tissue_expression_down	hsa-mir-142	Colon Neoplasms	26556872			D12.6	D003110		HP:0100273	highly up-regulated miRNAs, let-7f-5p, miR-455-3p, miR-98, miR-155-5p and the down-regulated miRNAs, miR-1, miR-127-5p, miR-142-5p, miR-202-5p were associated with colon cancer pathways
tissue_expression_down	hsa-mir-146a	Colon Neoplasms	20859756			D12.6	D003110		HP:0100273	miR-146a:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection.
tissue_expression_down	hsa-mir-152	Colon Neoplasms	20859756			D12.6	D003110		HP:0100273	miR-152:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection.
tissue_expression_down	hsa-mir-155	Colon Neoplasms	20859756			D12.6	D003110		HP:0100273	miR-155:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection.
tissue_expression_down	hsa-mir-17	Colon Neoplasms	23436804			D12.6	D003110		HP:0100273	We detect and confirm 27 miRNAs to be significantly changed following ERβ expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ERβ's downregulatory effect on MYC. 
tissue_expression_down	hsa-mir-18	Colon Neoplasms	23436804			D12.6	D003110		HP:0100273	We detect and confirm 27 miRNAs to be significantly changed following ERβ expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ERβ's downregulatory effect on MYC. 
tissue_expression_down	hsa-mir-1826	Colon Neoplasms	19956872			D12.6	D003110		HP:0100273	The down-regulations of miR-197, miR-191, miR-92a, miR-93, miR-222 and miR-1826, whose expression was significantly down-regulated in both cell lines after the treatment of one drug or in one cell line following exposure to either drug, were further validated.
tissue_expression_down	hsa-mir-191	Colon Neoplasms	19956872			D12.6	D003110		HP:0100273	The down-regulations of miR-197, miR-191, miR-92a, miR-93, miR-222 and miR-1826, whose expression was significantly down-regulated in both cell lines after the treatment of one drug or in one cell line following exposure to either drug, were further validated.
tissue_expression_down	hsa-mir-197	Colon Neoplasms	19956872			D12.6	D003110		HP:0100273	The down-regulations of miR-197, miR-191, miR-92a, miR-93, miR-222 and miR-1826, whose expression was significantly down-regulated in both cell lines after the treatment of one drug or in one cell line following exposure to either drug, were further validated.
tissue_expression_down	hsa-mir-19a	Colon Neoplasms	23436804			D12.6	D003110		HP:0100273	We detect and confirm 27 miRNAs to be significantly changed following ERβ expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ERβ's downregulatory effect on MYC. 
tissue_expression_down	hsa-mir-19b-1	Colon Neoplasms	23436804			D12.6	D003110		HP:0100273	We detect and confirm 27 miRNAs to be significantly changed following ERβ expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ERβ's downregulatory effect on MYC. 
tissue_expression_down	hsa-mir-200a	Colon Neoplasms	23436804			D12.6	D003110		HP:0100273	We detect and confirm 27 miRNAs to be significantly changed following ERβ expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ERβ's downregulatory effect on MYC. 
tissue_expression_down	hsa-mir-200b	Colon Neoplasms	23436804			D12.6	D003110		HP:0100273	We detect and confirm 27 miRNAs to be significantly changed following ERβ expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ERβ's downregulatory effect on MYC. 
tissue_expression_down	hsa-mir-200b	Colon Neoplasms	25846512			D12.6	D003110		HP:0100273	The activation of PAR1 on the platelets led to the inhibition of miR-200b expression in the SW620 cells that were cultured in platelet-conditioned media.
tissue_expression_down	hsa-mir-200b	Colon Neoplasms	28552992			D12.6	D003110		HP:0100273	MicroRNA-200b is downregulated in colon cancer budding cells.
tissue_expression_down	hsa-mir-200b	Colon Neoplasms	28821160			D12.6	D003110		HP:0100273	downregulation of AKT, NF-κB, Bcl-XL expressions and some key oncomicroRNAs such as miRNA-21 and miRNA-200b significantly
tissue_expression_down	hsa-mir-205	Colon Neoplasms	20859756			D12.6	D003110		HP:0100273	miR-205:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection.
tissue_expression_down	hsa-mir-20a	Colon Neoplasms	23436804			D12.6	D003110		HP:0100273	We detect and confirm 27 miRNAs to be significantly changed following ERβ expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ERβ's downregulatory effect on MYC. 
tissue_expression_down	hsa-mir-21	Colon Neoplasms	28821160			D12.6	D003110		HP:0100273	downregulation of AKT, NF-κB, Bcl-XL expressions and some key oncomicroRNAs such as miRNA-21 and miRNA-200b significantly
tissue_expression_down	hsa-mir-222	Colon Neoplasms	19956872			D12.6	D003110		HP:0100273	The down-regulations of miR-197, miR-191, miR-92a, miR-93, miR-222 and miR-1826, whose expression was significantly down-regulated in both cell lines after the treatment of one drug or in one cell line following exposure to either drug, were further validated.
tissue_expression_down	hsa-mir-365a	Colon Neoplasms	20859756			D12.6	D003110		HP:0100273	miR-365:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection.
tissue_expression_down	hsa-mir-365a	Colon Neoplasms	22072615			D12.6	D003110		HP:0100273	microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2.
tissue_expression_down	hsa-mir-365b	Colon Neoplasms	20859756			D12.6	D003110		HP:0100273	miR-365:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection.
tissue_expression_down	hsa-mir-378	Colon Neoplasms	20132431			D12.6	D003110		HP:0100273	A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control.
tissue_expression_down	hsa-mir-449a	Colon Neoplasms	20859756			D12.6	D003110		HP:0100273	miR-449:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection.
tissue_expression_down	hsa-mir-486	Colon Neoplasms	19946373			D12.6	D003110		HP:0100273	miR-486-5p: downregulated
tissue_expression_down	hsa-mir-518c	Colon Neoplasms	20859756			D12.6	D003110		HP:0100273	miR-518c:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection.
tissue_expression_down	hsa-mir-524	Colon Neoplasms	22180714			D12.6	D003110		HP:0100273	Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc.
tissue_expression_down	hsa-mir-552	Colon Neoplasms	20859756			D12.6	D003110		HP:0100273	miR-552:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection.
tissue_expression_down	hsa-mir-561	Colon Neoplasms	22180714			D12.6	D003110		HP:0100273	Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc.
tissue_expression_down	hsa-mir-584	Colon Neoplasms	20859756			D12.6	D003110		HP:0100273	miR-584:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection.
tissue_expression_down	hsa-mir-615	Colon Neoplasms	20859756			D12.6	D003110		HP:0100273	miR-615:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection.
tissue_expression_down	hsa-mir-622	Colon Neoplasms	20859756			D12.6	D003110		HP:0100273	miR-622:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection.
tissue_expression_down	hsa-mir-630	Colon Neoplasms	20859756			D12.6	D003110		HP:0100273	miR-630:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection.
tissue_expression_down	hsa-mir-886	Colon Neoplasms	22180714			D12.6	D003110		HP:0100273	Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc.
tissue_expression_down	hsa-mir-92-1	Colon Neoplasms	23436804			D12.6	D003110		HP:0100273	We detect and confirm 27 miRNAs to be significantly changed following ERβ expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ERβ's downregulatory effect on MYC. 
tissue_expression_down	hsa-mir-92a	Colon Neoplasms	19956872			D12.6	D003110		HP:0100273	The down-regulations of miR-197, miR-191, miR-92a, miR-93, miR-222 and miR-1826, whose expression was significantly down-regulated in both cell lines after the treatment of one drug or in one cell line following exposure to either drug, were further validated.
tissue_expression_down	hsa-mir-93	Colon Neoplasms	19956872			D12.6	D003110		HP:0100273	The down-regulations of miR-197, miR-191, miR-92a, miR-93, miR-222 and miR-1826, whose expression was significantly down-regulated in both cell lines after the treatment of one drug or in one cell line following exposure to either drug, were further validated.
tissue_expression_down	hsa-mir-93	Colon Neoplasms	22180714			D12.6	D003110		HP:0100273	Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc.
tissue_expression_down	hsa-let-7a-1	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		let-7a:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC
tissue_expression_down	hsa-let-7a-2	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		let-7a:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC
tissue_expression_down	hsa-let-7a-3	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		let-7a:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC
tissue_expression_down	hsa-mir-143	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-143:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC
tissue_expression_down	hsa-mir-145	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-145:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC
tissue_expression_down	hsa-mir-16-1	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-16:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC
tissue_expression_down	hsa-mir-16-2	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-16:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC
tissue_expression_down	hsa-mir-191	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-191:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC
tissue_expression_down	hsa-mir-192	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-192:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC
tissue_expression_down	hsa-mir-196a-1	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-196a:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC
tissue_expression_down	hsa-mir-196a-2	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-196a:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC
tissue_expression_down	hsa-mir-215	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-215:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC
tissue_expression_down	hsa-mir-26b	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-26b:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC
tissue_expression_down	hsa-let-7a	Colorectal Carcinoma	27262492	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		down-regulation of let-7a-5p in serums and tumour tissues of CRC patients could be used to predict lymph node metastasis and the disease prognosis.
tissue_expression_down	hsa-mir-100	Colorectal Carcinoma	25216869	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Downregulation of microRNA-100 correlates with tumor progression and poor prognosis in colorectal cancer.
tissue_expression_down	hsa-mir-100	Colorectal Carcinoma	28032929	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Downregulation of microRNA-100/microRNA-125b is associated with lymph node metastasis in early colorectal cancer with submucosal invasion.
tissue_expression_down	hsa-mir-124	Colorectal Carcinoma	25987767	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-124 promotes hyperplasia and contributes to invasion of CRC cells, but downregulates ROCK1. ROCK1 and miR-124 may play important roles in CRC.
tissue_expression_down	hsa-mir-125b	Colorectal Carcinoma	28032929	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Downregulation of microRNA-100/microRNA-125b is associated with lymph node metastasis in early colorectal cancer with submucosal invasion.
tissue_expression_down	hsa-mir-126	Colorectal Carcinoma	24532280	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Low expression of microRNA-126 is associated with poor prognosis in colorectal cancer.
tissue_expression_down	hsa-mir-126	Colorectal Carcinoma	24994098	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Underexpression of miR-126 and miR-20b was observed in various types of colorectal cancer, and occurs as an early event of colorectal carcinogenesis in FAP tumors.
tissue_expression_down	hsa-mir-1295b	Colorectal Carcinoma	25519020	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression of miR-4478 and miR-1295b-3p were significantly diminished in stool samples of CRC patients with early stage (I, II) in comparison with normal group. These miRNAs maybe use as potential non-invasive molecular markers for CRC diagnosis, but further studies are needed.
tissue_expression_down	hsa-mir-130b	Colorectal Carcinoma	24498407	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MicroRNA- 130b suppresses migration and invasion of colorectal cancer cells through downregulation of integrin β1 [corrected].
tissue_expression_down	hsa-mir-133a	Colorectal Carcinoma	25170220	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The downregulation of miR-133a may play an important role in the progression of CRC and can be used as an independent factor to determine CRC prognosis.
tissue_expression_down	hsa-mir-143	Colorectal Carcinoma	24875473	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		we discuss the early reports on the identification of dysregulated miR-143 and miR-145 expression in colorectal cancer and how lack of consideration of cellular composition of normal tissue led to the misconception that these miRNAs are downregulated in cancer. We evaluate mechanistic data from miR-143/145 studies in context of their cell type-restricted expression pattern and the potential of these miRNAs to be considered tumor suppressors.
tissue_expression_down	hsa-mir-143	Colorectal Carcinoma	21551242	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiR-20a and miR-31 were found to be significantly upregulated in more than one study, and miR-143 and miR-145 were found to be significantly downregulated in CRC tissue in six or more studies.
tissue_expression_down	hsa-mir-145	Colorectal Carcinoma	24875473	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		we discuss the early reports on the identification of dysregulated miR-143 and miR-145 expression in colorectal cancer and how lack of consideration of cellular composition of normal tissue led to the misconception that these miRNAs are downregulated in cancer. We evaluate mechanistic data from miR-143/145 studies in context of their cell type-restricted expression pattern and the potential of these miRNAs to be considered tumor suppressors.
tissue_expression_down	hsa-mir-145	Colorectal Carcinoma	21551242	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiR-20a and miR-31 were found to be significantly upregulated in more than one study, and miR-143 and miR-145 were found to be significantly downregulated in CRC tissue in six or more studies.
tissue_expression_down	hsa-mir-145	Colorectal Carcinoma	25736690	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Significant downregulation of miR-145 in CRC group was reported at all levels
tissue_expression_down	hsa-mir-148a	Colorectal Carcinoma	28863773	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Down-regulation of miRNA-148a and miRNA-625-3p in colorectal cancer is associated with tumor budding.
tissue_expression_down	hsa-mir-193a	Colorectal Carcinoma	25232258	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Downregulation of miR-193a-5p correlates with lymph node metastasis and poor survival of CRC. miR-193a-5p may be a useful biomarker for CRC diagnosis, metastasis and prognosis prediction.
tissue_expression_down	hsa-mir-200a	Colorectal Carcinoma	24504363	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		In conclusion, our data suggest that low miR-200a expression is associated with poor prognosis in CRC patients. MiR-200a has a regulatory effect on EMT and is associated with cancer stem cell properties in CRC.
tissue_expression_down	hsa-mir-203	Colorectal Carcinoma	27253631	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-203 was found to be downregulated in all polyps and CRC specimens
tissue_expression_down	hsa-mir-20b	Colorectal Carcinoma	24994098	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Underexpression of miR-126 and miR-20b was observed in various types of colorectal cancer, and occurs as an early event of colorectal carcinogenesis in FAP tumors.
tissue_expression_down	hsa-mir-21	Colorectal Carcinoma	23773491	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		In Taiwan, downregulation of the APC gene in CRC correlated with gene mutation and mir-21 upregulation. APC mutation and mir-21 expression could be used to predict the clinical outcome of CRC, especially in patients with advanced disease.
tissue_expression_down	hsa-mir-214	Colorectal Carcinoma	24760176	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Downregulation of miR-214 is specific of liver metastasis in colorectal cancer and could play a role determining the metastatic niche.
tissue_expression_down	hsa-mir-218	Colorectal Carcinoma	24294377	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Decreased expression of miR-218 is associated with poor prognosis in patients with colorectal cancer.
tissue_expression_down	hsa-mir-27b	Colorectal Carcinoma	23593282	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		we demonstrated that miR-27b expression is decreased in most CRC tissues and determined that overexpression of miR-27b represses CRC cell proliferation, colony formation and tumor growth in vitro and in vivo.
tissue_expression_down	hsa-mir-29c	Colorectal Carcinoma	26187071	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiR-29c downregulation contributes to metastatic progression in colorectal cancer.
tissue_expression_down	hsa-mir-31	Colorectal Carcinoma	22740910	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas.
tissue_expression_down	hsa-mir-340	Colorectal Carcinoma	24448820	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Decreased miR-340 expression in bone marrow is associated with liver metastasis of colorectal cancer.
tissue_expression_down	hsa-mir-34a	Colorectal Carcinoma	26091352	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		the concentration of s-IL6R protein was decreased in conditioned media of CRC cell lines ectopically expressing miR-34a.
tissue_expression_down	hsa-mir-375	Colorectal Carcinoma	25255814	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Our results indicate that the down-regulation of miR-375 in plasma and tissue is matched in CRC. Moreover, bioinformatics prediction revealed miR-375 association with some critical signal pathways in the development and progression of CRC. Therefore, plasma miR-375 holds great promise to be an alternative tissue biomarker for CRC detection.
tissue_expression_down	hsa-mir-422a	Colorectal Carcinoma	27350737	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Down-regulation of miR-422a may serve as an independent prognosis factor in CRC.
tissue_expression_down	hsa-mir-4478	Colorectal Carcinoma	25519020	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression of miR-4478 and miR-1295b-3p were significantly diminished in stool samples of CRC patients with early stage (I, II) in comparison with normal group. These miRNAs maybe use as potential non-invasive molecular markers for CRC diagnosis, but further studies are needed.
tissue_expression_down	hsa-mir-452	Colorectal Carcinoma	27706792	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Decreased miR-452 expression in human colorectal cancer and its tumor suppressive function
tissue_expression_down	hsa-mir-490	Colorectal Carcinoma	26714817	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-490-3p is downregulated during CRC malignant progression.miR-490-3p represses CRC cell migration and invasion abilities, partially by targeting to the TGF-β signaling pathway. Taken together, miR-490-3p is acting as a tumor suppressor in CRC.
tissue_expression_down	hsa-mir-498	Colorectal Carcinoma	25128149	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Downregulation of microRNA-498 in colorectal cancers and its cellular effects.
tissue_expression_down	hsa-mir-625	Colorectal Carcinoma	28863773	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Down-regulation of miRNA-148a and miRNA-625-3p in colorectal cancer is associated with tumor budding.
tissue_expression_down	hsa-let-7e	Colorectal Carcinoma	22241525	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Six miRNAs were up-regulated from non-neoplastic tissue to dysplasia, but down-regulated from dysplasia to cancer (miR-122, miR-181a, miR-146b-5p, let-7e, miR-17, miR-143)
tissue_expression_down	hsa-mir-106a	Colorectal Carcinoma	23178825	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-106a overexpression and pRB downregulation in sporadic colorectal cancer
tissue_expression_down	hsa-mir-122	Colorectal Carcinoma	22241525	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Six miRNAs were up-regulated from non-neoplastic tissue to dysplasia, but down-regulated from dysplasia to cancer (miR-122, miR-181a, miR-146b-5p, let-7e, miR-17, miR-143)
tissue_expression_down	hsa-mir-127	Colorectal Carcinoma	21922590	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The presence of the KRAS mutation was associated with up-regulation of miR-127-3p, miR-92a, and miR-486-3p and down-regulation of miR-378.
tissue_expression_down	hsa-mir-133b	Colorectal Carcinoma	21573504	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		High expression of miR-185 and low expression of miR-133b were correlated with poor survival (p=0.001 and 0.028, respectively) and metastasis (p=0.007 and 0.036, respectively) in colorectal cancer.
tissue_expression_down	hsa-mir-141	Colorectal Carcinoma	25757925	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Induction of epithelial-mesenchymal transition and down-regulation of miR-200c and miR-141 in oxaliplatin-resistant colorectal cancer cells.
tissue_expression_down	hsa-mir-143	Colorectal Carcinoma	19287964	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-143: down-regualted
tissue_expression_down	hsa-mir-143	Colorectal Carcinoma	21826996	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		downregulated in colon cancer compared to normal colonic mucosa
tissue_expression_down	hsa-mir-143	Colorectal Carcinoma	22241525	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Six miRNAs were up-regulated from non-neoplastic tissue to dysplasia, but down-regulated from dysplasia to cancer (miR-122, miR-181a, miR-146b-5p, let-7e, miR-17, miR-143)
tissue_expression_down	hsa-mir-143	Colorectal Carcinoma	22273643	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Down-regulation of fecal miR-143 and miR-145 are potential markers for colorectal cancer.
tissue_expression_down	hsa-mir-145	Colorectal Carcinoma	19287964	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-145: down-regulated
tissue_expression_down	hsa-mir-145	Colorectal Carcinoma	21826996	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		downregulated in colon cancer compared to normal colonic mucosa
tissue_expression_down	hsa-mir-145	Colorectal Carcinoma	22273643	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Down-regulation of fecal miR-143 and miR-145 are potential markers for colorectal cancer.
tissue_expression_down	hsa-mir-146b	Colorectal Carcinoma	22241525	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Six miRNAs were up-regulated from non-neoplastic tissue to dysplasia, but down-regulated from dysplasia to cancer (miR-122, miR-181a, miR-146b-5p, let-7e, miR-17, miR-143)
tissue_expression_down	hsa-mir-148a	Colorectal Carcinoma	26389729	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		We showed the collaborative participation of miR-148a and MMP7 in CRC cell invasion. These results also demonstrate that the downregulation of miR-148a expression promotes CRC progression, especially carcinogenesis and cancer cell invasion.
tissue_expression_down	hsa-mir-154	Colorectal Carcinoma	26048406	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		These findings suggested that miR-154 downregulation may be associated with tumor progression of CRC, and that this miR may be an independent prognostic marker for CRC patients.
tissue_expression_down	hsa-mir-16	Colorectal Carcinoma	24045965	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Down-regulation of miR-16 plays critical roles in CRC progression.Low miR-16 expression is an independent factor predicting a poor prognosis for CRC patients.
tissue_expression_down	hsa-mir-17	Colorectal Carcinoma	22241525	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Six miRNAs were up-regulated from non-neoplastic tissue to dysplasia, but down-regulated from dysplasia to cancer (miR-122, miR-181a, miR-146b-5p, let-7e, miR-17, miR-143)
tissue_expression_down	hsa-mir-181a-2	Colorectal Carcinoma	22241525	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Six miRNAs were up-regulated from non-neoplastic tissue to dysplasia, but down-regulated from dysplasia to cancer (miR-122, miR-181a, miR-146b-5p, let-7e, miR-17, miR-143)
tissue_expression_down	hsa-mir-195	Colorectal Carcinoma	21390519	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Downregulation of miR-195 correlates with lymph node metastasis and poor prognosis in colorectal cancer.
tissue_expression_down	hsa-mir-199a-1	Colorectal Carcinoma	22903020	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-199a-5p was expressed at a low level in human primary colonic epithelial cells treated with deoxycholic acid compared with control, and miR-199a-5p was significantly down-regulated in colorectal cancer tissues.CAC1 was a direct miR-199a-5p target.The high miR-199a-5p expression and low CAC1 protein expression reverse the tumor cell drug resistance.
tissue_expression_down	hsa-mir-199a-2	Colorectal Carcinoma	22903020	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-199a-5p was expressed at a low level in human primary colonic epithelial cells treated with deoxycholic acid compared with control, and miR-199a-5p was significantly down-regulated in colorectal cancer tissues.CAC1 was a direct miR-199a-5p target.The high miR-199a-5p expression and low CAC1 protein expression reverse the tumor cell drug resistance.
tissue_expression_down	hsa-mir-200c	Colorectal Carcinoma	25757925	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Induction of epithelial-mesenchymal transition and down-regulation of miR-200c and miR-141 in oxaliplatin-resistant colorectal cancer cells.
tissue_expression_down	hsa-mir-206	Colorectal Carcinoma	22120473	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases.
tissue_expression_down	hsa-mir-21	Colorectal Carcinoma	25310697	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Inflammation and MiR-21 pathways functionally interact to downregulate PDCD4 incolorectal cancer.
tissue_expression_down	hsa-mir-215	Colorectal Carcinoma	22469014	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiR-215, miR-375, miR-378 and miR-422a were significantly decreased, whereas miR-135b was increased in CRC tumor tissues. Levels of miR-215 and miR-422a correlated with clinical stage.
tissue_expression_down	hsa-mir-22	Colorectal Carcinoma	22492279	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The relative expression levels of miR-22 were significantly lower in colorectal cancer tissues than those in the normal adjacent mucosa, and low expression of miR-22 correlated with liver metastasis. Kaplan-Meier analysis indicated that patients with reduced miR-22 had a poor overall survival.
tissue_expression_down	hsa-mir-224	Colorectal Carcinoma	21864507	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Underexpression in methotrexate resistant human colon cancer cells.
tissue_expression_down	hsa-mir-34a	Colorectal Carcinoma	23355243	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The down-regulated expression of miR-34a in colorectal cancer patients is associated with recurrence after radical operation
tissue_expression_down	hsa-mir-375	Colorectal Carcinoma	22377847	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-375 expression was frequently downregulated in the colorectal cancer tissues compared to the non-tumor counterparts
tissue_expression_down	hsa-mir-378a	Colorectal Carcinoma	22469014	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiR-215, miR-375, miR-378 and miR-422a were significantly decreased, whereas miR-135b was increased in CRC tumor tissues. Levels of miR-215 and miR-422a correlated with clinical stage.
tissue_expression_down	hsa-mir-422a	Colorectal Carcinoma	22469014	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiR-215, miR-375, miR-378 and miR-422a were significantly decreased, whereas miR-135b was increased in CRC tumor tissues. Levels of miR-215 and miR-422a correlated with clinical stage.
tissue_expression_down	hsa-mir-451	Colorectal Carcinoma	23886157	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MicroRNA-451 inhibits growth of human colorectal carcinoma cells via downregulation of Pi3k/Akt pathway.
tissue_expression_down	hsa-mir-486	Colorectal Carcinoma	21922590	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The presence of the KRAS mutation was associated with up-regulation of miR-127-3p, miR-92a, and miR-486-3p and down-regulation of miR-378.
tissue_expression_down	hsa-mir-92a-1	Colorectal Carcinoma	21922590	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The presence of the KRAS mutation was associated with up-regulation of miR-127-3p, miR-92a, and miR-486-3p and down-regulation of miR-378.
tissue_expression_down	hsa-mir-92a-2	Colorectal Carcinoma	21922590	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The presence of the KRAS mutation was associated with up-regulation of miR-127-3p, miR-92a, and miR-486-3p and down-regulation of miR-378.
tissue_expression_down	hsa-mir-93	Colorectal Carcinoma	23354160	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		the downregulation of miR-93 was significantly correlated with unfavorable clinicopathologic features and short overall survival in patients with colon cancer, suggesting that decreased expression of miR-93 be used as a novel prognostic factor for this disease
tissue_expression_down	hsa-mir-451	Constriction, Pathologic	26573748				D003251			MiRNA array of 1416 genes showed that in stenosed grafts, mir-451, mir-338, and mir-466 were downregulated and mir-154 was upregulated.
tissue_expression_down	hsa-mir-181a-2	Coronary Artery Disease	22535975	cardiovascular system disease	DOID:3393	I20-I25	D003324	608320		Decreased miR-181a Expression in Monocytes of Obese Patients Is Associated with the Occurrence of Metabolic Syndrome and Coronary Artery Disease.
tissue_expression_down	hsa-mir-147	Crohn Disease	25810742	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	miR-147 and miR-205 were significantly downregulated in colons of experimental CD rats and may be closely associated with the onset of experimental CD.
tissue_expression_down	hsa-mir-19b	Crohn Disease	25997679	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	miR-19b downregulates intestinal SOCS3 to reduce intestinal inflammation in Crohn's disease.
tissue_expression_down	hsa-mir-137	Cutaneous Melanoma	26763596	disease of cellular proliferation	DOID:8923	C43	C562393	PS155600	HP:0012056	miR-137 expression was lower in CM tissues.
tissue_expression_down	hsa-mir-217	Cytomegalovirus Retinitis	24376725	nervous system disease	DOID:0080160	B25.9	D017726			MicroRNA-217 promotes angiogenesis of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and FOXO3A. hcmv-miR-UL112-3p
tissue_expression_down	hsa-mir-130a	Diabetes Mellitus	25999017	disease of metabolism	DOID:9351	E10-E14	D003920	222100	HP:0000819	Downregulation of miR-130a may underlie endothelial dysfunction in diabetes through the activation of JNK signal pathway.
tissue_expression_down	hsa-mir-146a	Diabetes Mellitus	21885871	disease of metabolism	DOID:9351	E10-E14	D003920	222100	HP:0000819	A total of 25 mmol/L glucose decreased miR-146a expression and increased FN expression compared with 5 mmol/L glucose in both cell types. miR-146a mimic transfection prevented such change, whereas miR-146a antagomir transfection in the cells in 5 mmol/L glucose caused FN upregulation. A luciferase assay confirmed miR-146a's binding to FN 3'-UTR. miR-146a was localized in the retinal endothelial cells and was decreased in diabetes. Intravitreal miR-146a mimic injection restored retinal miR-146a and increased FN in diabetes. Additional experiments showed that p300 regulates miR-146a.
tissue_expression_down	hsa-mir-200	Diabetes Mellitus, Type 1	26244930	disease of metabolism	DOID:9744	E10	D003922	222100	HP:0100651	These data strongly associate miR200-mediated downregulation of the DNA damage checkpoint proteins with propensity for developing microvascular complications of T1D.
tissue_expression_down	hsa-mir-21	Diabetes Mellitus, Type 2	27370645	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	miR-21 expression is decreased in PBMCs of obese subjects
tissue_expression_down	hsa-mir-23b	Diabetic Cardiomyopathies	24670789				D058065			CA-II was shown to be a direct target for repression by microRNA-23b, which was downregulated in myocardial samples from DM-T2 patients.
tissue_expression_down	hsa-mir-200a	Diabetic Nephropathy	22211842			E10-11.21	D003928			TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated.
tissue_expression_down	hsa-mir-200b	Diabetic Nephropathy	22211842			E10-11.21	D003928			TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated.
tissue_expression_down	hsa-mir-200c	Diabetic Nephropathy	22211842			E10-11.21	D003928			TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated.
tissue_expression_down	hsa-mir-26a	Diabetic Nephropathy	26063197			E10-11.21	D003928			MicroRNA-26a inhibits TGF-β-induced extracellular matrix protein expression in podocytes by targeting CTGF and is downregulated in diabetic nephropathy.
tissue_expression_down	hsa-mir-29a	Diabetic Nephropathy	22211842			E10-11.21	D003928			TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated.
tissue_expression_down	hsa-mir-29b-1	Diabetic Nephropathy	22211842			E10-11.21	D003928			TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated.
tissue_expression_down	hsa-mir-29b-2	Diabetic Nephropathy	22211842			E10-11.21	D003928			TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated.
tissue_expression_down	hsa-mir-29c	Diabetic Nephropathy	22211842			E10-11.21	D003928			TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated.
tissue_expression_down	hsa-let-7a-1	Digestive System Neoplasms	19156147			D49.0	D004067			let-7a: downregulation
tissue_expression_down	hsa-let-7a-2	Digestive System Neoplasms	19156147			D49.0	D004067			let-7a: downregulation
tissue_expression_down	hsa-let-7a-3	Digestive System Neoplasms	19156147			D49.0	D004067			let-7a: downregulation
tissue_expression_down	hsa-let-7b	Digestive System Neoplasms	19156147			D49.0	D004067			let-7b: downregulation
tissue_expression_down	hsa-let-7c	Digestive System Neoplasms	19156147			D49.0	D004067			let-7c: downregulation
tissue_expression_down	hsa-let-7d	Digestive System Neoplasms	19156147			D49.0	D004067			let-7d: downregulation
tissue_expression_down	hsa-let-7e	Digestive System Neoplasms	19156147			D49.0	D004067			let-7e: downregulation
tissue_expression_down	hsa-let-7f-1	Digestive System Neoplasms	19156147			D49.0	D004067			let-7f: downregulation
tissue_expression_down	hsa-let-7f-2	Digestive System Neoplasms	19156147			D49.0	D004067			let-7f: downregulation
tissue_expression_down	hsa-let-7g	Digestive System Neoplasms	19156147			D49.0	D004067			let-7g: downregulation
tissue_expression_down	hsa-let-7i	Digestive System Neoplasms	19156147			D49.0	D004067			let-7i: downregulation
tissue_expression_down	hsa-mir-101	Early-Stage Cervical Squamous Cell Carcinoma	24528073							Use of down-regulation of miR-101 and up-regulation of Cox-2 as markers may play a role in early diagnosis of cervical cancer in Uygur women.
tissue_expression_down	hsa-mir-196	Ectopic Pregnancy	25013942	reproductive system disease	DOID:0060329	O00.9	D011271		HP:0031456	Microarray studies showed that four miRNAs were differentially  downregulated (hsa-mir-196b, hsa-mir-30a, hsa-mir-873, and hsa-mir-337-3p) and three upregulated (hsa-mir-1288, hsa-mir-451, and hsa-mir-223) in EP compared to  control tissue samples.
tissue_expression_down	hsa-mir-196b	Ectopic Pregnancy	25013942	reproductive system disease	DOID:0060329	O00.9	D011271		HP:0031456	Microarray studies showed that four miRNAs were differentially  downregulated (hsa-mir-196b, hsa-mir-30a, hsa-mir-873, and hsa-mir-337-3p) and three upregulated (hsa-mir-1288, hsa-mir-451, and hsa-mir-223) in EP compared to  control tissue samples.
tissue_expression_down	hsa-mir-30a	Ectopic Pregnancy	25013942	reproductive system disease	DOID:0060329	O00.9	D011271		HP:0031456	Microarray studies showed that four miRNAs were differentially  downregulated (hsa-mir-196b, hsa-mir-30a, hsa-mir-873, and hsa-mir-337-3p) and three upregulated (hsa-mir-1288, hsa-mir-451, and hsa-mir-223) in EP compared to  control tissue samples.
tissue_expression_down	hsa-mir-337	Ectopic Pregnancy	25013942	reproductive system disease	DOID:0060329	O00.9	D011271		HP:0031456	Microarray studies showed that four miRNAs were differentially  downregulated (hsa-mir-196b, hsa-mir-30a, hsa-mir-873, and hsa-mir-337-3p) and three upregulated (hsa-mir-1288, hsa-mir-451, and hsa-mir-223) in EP compared to  control tissue samples.
tissue_expression_down	hsa-mir-873	Ectopic Pregnancy	25013942	reproductive system disease	DOID:0060329	O00.9	D011271		HP:0031456	Microarray studies showed that four miRNAs were differentially  downregulated (hsa-mir-196b, hsa-mir-30a, hsa-mir-873, and hsa-mir-337-3p) and three upregulated (hsa-mir-1288, hsa-mir-451, and hsa-mir-223) in EP compared to  control tissue samples.
tissue_expression_down	hsa-mir-101	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-126	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-137	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-195	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-200a	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-200b	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-200c	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-141	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-429	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-205	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-206	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-29a	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-30a	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-539	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-613	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-7	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-9	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_down	hsa-mir-100	Endometrial Neoplasms	22920721	reproductive system disease	DOID:1380	C54.1	D016889	608089		Deregulation of miR-100, miR-99a and miR-199b in tissues and plasma coexists with increased expression of mTOR kinase in endometrioid endometrial carcinoma.
tissue_expression_down	hsa-mir-153-1	Endometrial Neoplasms	20028871	reproductive system disease	DOID:1380	C54.1	D016889	608089		Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1
tissue_expression_down	hsa-mir-153-2	Endometrial Neoplasms	20028871	reproductive system disease	DOID:1380	C54.1	D016889	608089		Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1
tissue_expression_down	hsa-mir-182	Endometrial Neoplasms	20028871	reproductive system disease	DOID:1380	C54.1	D016889	608089		Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1
tissue_expression_down	hsa-mir-183	Endometrial Neoplasms	20028871	reproductive system disease	DOID:1380	C54.1	D016889	608089		Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1
tissue_expression_down	hsa-mir-186	Endometrial Neoplasms	20028871	reproductive system disease	DOID:1380	C54.1	D016889	608089		Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1
tissue_expression_down	hsa-mir-193b	Endometrial Neoplasms	22543862	reproductive system disease	DOID:1380	C54.1	D016889	608089		Decreased expression after Progesterone Treatment.
tissue_expression_down	hsa-mir-27a	Endometrial Neoplasms	20028871	reproductive system disease	DOID:1380	C54.1	D016889	608089		Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1
tissue_expression_down	hsa-mir-27b	Endometrial Neoplasms	20028871	reproductive system disease	DOID:1380	C54.1	D016889	608089		Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1
tissue_expression_down	hsa-mir-29c	Endometrial Neoplasms	22543862	reproductive system disease	DOID:1380	C54.1	D016889	608089		Decreased expression after Progesterone Treatment.
tissue_expression_down	hsa-mir-633	Endometrial Neoplasms	22543862	reproductive system disease	DOID:1380	C54.1	D016889	608089		Decreased expression after Progesterone Treatment.
tissue_expression_down	hsa-mir-9-1	Endometrial Neoplasms	20028871	reproductive system disease	DOID:1380	C54.1	D016889	608089		Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1
tissue_expression_down	hsa-mir-9-2	Endometrial Neoplasms	20028871	reproductive system disease	DOID:1380	C54.1	D016889	608089		Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1
tissue_expression_down	hsa-mir-9-3	Endometrial Neoplasms	20028871	reproductive system disease	DOID:1380	C54.1	D016889	608089		Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1
tissue_expression_down	hsa-mir-96	Endometrial Neoplasms	20028871	reproductive system disease	DOID:1380	C54.1	D016889	608089		Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1
tissue_expression_down	hsa-mir-10a	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	down-regulated in endometriomas compared with endometrium.
tissue_expression_down	hsa-mir-141	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-141: downregulated
tissue_expression_down	hsa-mir-141	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	down-regulated in endometriomas compared with endometrium.
tissue_expression_down	hsa-mir-142	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-142-3p: downregulated
tissue_expression_down	hsa-mir-196b	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-196b: downregulated
tissue_expression_down	hsa-mir-200a	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-200a: downregulated
tissue_expression_down	hsa-mir-200a	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	down-regulated in endometriomas compared with endometrium.
tissue_expression_down	hsa-mir-200b	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-200b: downregulated
tissue_expression_down	hsa-mir-200b	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	down-regulated in endometriomas compared with endometrium.
tissue_expression_down	hsa-mir-200c	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	down-regulated in endometriomas compared with endometrium.
tissue_expression_down	hsa-mir-203	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	down-regulated in endometriomas compared with endometrium.
tissue_expression_down	hsa-mir-20a	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-20a: downregulated
tissue_expression_down	hsa-mir-34c	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-34c: downregulated
tissue_expression_down	hsa-mir-34c	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-34c-5p down-regulated in endometriomas compared with endometrium.
tissue_expression_down	hsa-mir-375	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	down-regulated in endometriomas compared with endometrium.
tissue_expression_down	hsa-mir-424	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-424: downregulated
tissue_expression_down	hsa-mir-429	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	down-regulated in endometriomas compared with endometrium.
tissue_expression_down	hsa-mir-449b	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	down-regulated in endometriomas compared with endometrium.
tissue_expression_down	hsa-mir-504	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	down-regulated in endometriomas compared with endometrium.
tissue_expression_down	hsa-mir-873	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	down-regulated in endometriomas compared with endometrium.
tissue_expression_down	hsa-let-7g	Endotoxemia	19284987				D019446			Data analysis revealed that five miRNAs consistently responded to LPS-infusion, four of which were down-regulated (miR-146b, miR-150, miR-342, and let-7g) and one was up-regulated (miR-143). The miR-150 and mir-342 response was confirmed by real-time PCR.
tissue_expression_down	hsa-mir-146b	Endotoxemia	19284987				D019446			Data analysis revealed that five miRNAs consistently responded to LPS-infusion, four of which were down-regulated (miR-146b, miR-150, miR-342, and let-7g) and one was up-regulated (miR-143). The miR-150 and mir-342 response was confirmed by real-time PCR.
tissue_expression_down	hsa-mir-150	Endotoxemia	19284987				D019446			Data analysis revealed that five miRNAs consistently responded to LPS-infusion, four of which were down-regulated (miR-146b, miR-150, miR-342, and let-7g) and one was up-regulated (miR-143). The miR-150 and mir-342 response was confirmed by real-time PCR.
tissue_expression_down	hsa-mir-342	Endotoxemia	19284987				D019446			Data analysis revealed that five miRNAs consistently responded to LPS-infusion, four of which were down-regulated (miR-146b, miR-150, miR-342, and let-7g) and one was up-regulated (miR-143). The miR-150 and mir-342 response was confirmed by real-time PCR.
tissue_expression_down	hsa-mir-10a	Ependymoma	29658967	disease of cellular proliferation	DOID:5074	C71.0	D004806		HP:0002888	low expression of miR-10a and over-expression of miR-10b and miR-29a in ependymoma
tissue_expression_down	hsa-mir-383	Ependymoma	22053178	disease of cellular proliferation	DOID:5074	C71.0	D004806		HP:0002888	underexpression
tissue_expression_down	hsa-mir-485	Ependymoma	22053178	disease of cellular proliferation	DOID:5074	C71.0	D004806		HP:0002888	miR-485-5p: underexpression
tissue_expression_down	hsa-mir-182	Epstein-Barr Virus Infection	26401047			B27.90	D020031	300853		Here, we show that EBV-encoded LMP-1 is also involved in the downregulation of a cluster of three miRNAs, miR-183,-96, and -182, which are known to be also repressed in several cancers. We therefore identify yet another potential player in EBV-induced oncogenesis.
tissue_expression_down	hsa-mir-183	Epstein-Barr Virus Infection	26401047			B27.90	D020031	300853		Here, we show that EBV-encoded LMP-1 is also involved in the downregulation of a cluster of three miRNAs, miR-183,-96, and -182, which are known to be also repressed in several cancers. We therefore identify yet another potential player in EBV-induced oncogenesis.
tissue_expression_down	hsa-mir-96	Epstein-Barr Virus Infection	26401047			B27.90	D020031	300853		Here, we show that EBV-encoded LMP-1 is also involved in the downregulation of a cluster of three miRNAs, miR-183,-96, and -182, which are known to be also repressed in several cancers. We therefore identify yet another potential player in EBV-induced oncogenesis.
tissue_expression_down	hsa-let-7b	Esophageal Neoplasms	22847808			C15.9	D004938	133239	HP:0100751	Low expression of let-7b and let-7c in before-treatment biopsies from 74 patients of the training set correlated significantly with poor response to chemotherapy, both clinically and histopathologically.
tissue_expression_down	hsa-let-7c	Esophageal Neoplasms	22847808			C15.9	D004938	133239	HP:0100751	Low expression of let-7b and let-7c in before-treatment biopsies from 74 patients of the training set correlated significantly with poor response to chemotherapy, both clinically and histopathologically.
tissue_expression_down	hsa-let-7c	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_down	hsa-mir-100	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_down	hsa-mir-125b	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_down	hsa-mir-126	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	downregulated
tissue_expression_down	hsa-mir-1322	Esophageal Neoplasms	22315007			C15.9	D004938	133239	HP:0100751	miR-1322 could significantly down-regulate the ECRG2 with TCA3 allele (P<0.01), but it could not down-regulate the ECRG2 with TCA4 allele significantly (P>0.05). MicroRNA-1322 regulates ECRG2 allele specifically and acts as a potential biomarker in patients with esophageal squamous cell carcinoma.
tissue_expression_down	hsa-mir-135b	Esophageal Neoplasms	23477513			C15.9	D004938	133239	HP:0100751	patients with either decreased miR-135b or increased miR-145 expression in cancer tissue had improved disease-free survival
tissue_expression_down	hsa-mir-141	Esophageal Neoplasms	24155113			C15.9	D004938	133239	HP:0100751	The statistical significance of downregulation in hsa-miR-301a, hsa-miR-141 and hsa-miR-18b expression (P < 0.05) were confirmed by qRT-PCR.
tissue_expression_down	hsa-mir-143	Esophageal Neoplasms	21218087			C15.9	D004938	133239	HP:0100751	MiRNA profile in esophageal squamous cell carcinoma: Downregulation of miR-143 and miR-145.
tissue_expression_down	hsa-mir-145	Esophageal Neoplasms	21218087			C15.9	D004938	133239	HP:0100751	MiRNA profile in esophageal squamous cell carcinoma: Downregulation of miR-143 and miR-145.
tissue_expression_down	hsa-mir-145	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_down	hsa-mir-203	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_down	hsa-mir-205	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_down	hsa-mir-21	Esophageal Neoplasms	22363450			C15.9	D004938	133239	HP:0100751	Curcumin treatment down-regulate the expressions of Notch-1 specific microRNAs miR-21 and miR-34a, and upregulated tumor suppressor let-7a miRNA.
tissue_expression_down	hsa-mir-223	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	downregulated
tissue_expression_down	hsa-mir-27b	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_down	hsa-mir-30b	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	downregulated
tissue_expression_down	hsa-mir-34a	Esophageal Neoplasms	22363450			C15.9	D004938	133239	HP:0100751	Curcumin treatment down-regulate the expressions of Notch-1 specific microRNAs miR-21 and miR-34a, and upregulated tumor suppressor let-7a miRNA.
tissue_expression_down	hsa-mir-375	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_down	hsa-mir-454	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	downregulated
tissue_expression_down	hsa-mir-486	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	downregulated
tissue_expression_down	hsa-mir-518b	Esophageal Neoplasms	21269950			C15.9	D004938	133239	HP:0100751	hsa-mir-126 is upregulated and hsa-miR-518b is downregulated in esophageal squamous carcinoma
tissue_expression_down	hsa-mir-574	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	miR-574-3p:downregulated
tissue_expression_down	hsa-mir-1	Essential Thrombocythemia	19497108	disease of cellular proliferation	DOID:2224	D47.3	D013920	PS187950		Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a.
tissue_expression_down	hsa-mir-133a	Essential Thrombocythemia	19497108	disease of cellular proliferation	DOID:2224	D47.3	D013920	PS187950		Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a.
tissue_expression_down	hsa-mir-31	Ewing Sarcoma	24667836	musculoskeletal system disease	DOID:3369		D012512	612219	HP:0012254	Differentially expressed miRNAs in Ewing sarcoma compared to mesenchymal stem cells: low miR-31 expression with effects on proliferation and invasion.
tissue_expression_down	hsa-mir-183	Fatty Liver [unspecific]	19572984	disease of metabolism	DOID:9452	K76.0	D005234	613282	HP:0001397	down-regulated after Lieber-DeCarli ;
tissue_expression_down	hsa-mir-122	Fatty Liver, Non-Alcoholic	20956972	disease of metabolism	DOID:0080208	K75.81	D065626	613282		The miRNAs analysis showed the significant downregulation of three miRNAs (miR-122, miR-451 and miR-27) and the upregulation of miR-200a, miR-200b and miR-429 in HFD, SD-HF and HFD-HF rats
tissue_expression_down	hsa-mir-21	Fatty Liver, Non-Alcoholic	20956972	disease of metabolism	DOID:0080208	K75.81	D065626	613282		Besides, miR-21 expression was significantly decreased only in fructose-enriched diets.
tissue_expression_down	hsa-mir-27	Fatty Liver, Non-Alcoholic	20956972	disease of metabolism	DOID:0080208	K75.81	D065626	613282		The miRNAs analysis showed the significant downregulation of three miRNAs (miR-122, miR-451 and miR-27) and the upregulation of miR-200a, miR-200b and miR-429 in HFD, SD-HF and HFD-HF rats
tissue_expression_down	hsa-mir-451	Fatty Liver, Non-Alcoholic	20956972	disease of metabolism	DOID:0080208	K75.81	D065626	613282		The miRNAs analysis showed the significant downregulation of three miRNAs (miR-122, miR-451 and miR-27) and the upregulation of miR-200a, miR-200b and miR-429 in HFD, SD-HF and HFD-HF rats
tissue_expression_down	hsa-mir-197	Fibromatosis, Aggressive	28418912				D018222			The correlation between sporadic DTs and miRNA expression showed that miR-21-3p increased in mutated versus wild-type DTs, while miR-197-3p was decreased
tissue_expression_down	hsa-mir-143	Fibromyalgia	25803872	musculoskeletal system disease	DOID:631	M79.7	D005356			We propose a signature of five strikingly downregulated miRNAs (hsa-miR223-3p, hsa-miR451a, hsa-miR338-3p, hsa-miR143-3p and hsa-miR145-5p) to be used as biomarkers of FM. Validation in larger study groups is required before the results can be transferred to the clinic.
tissue_expression_down	hsa-mir-145	Fibromyalgia	25803872	musculoskeletal system disease	DOID:631	M79.7	D005356			We propose a signature of five strikingly downregulated miRNAs (hsa-miR223-3p, hsa-miR451a, hsa-miR338-3p, hsa-miR143-3p and hsa-miR145-5p) to be used as biomarkers of FM. Validation in larger study groups is required before the results can be transferred to the clinic.
tissue_expression_down	hsa-mir-21	Fibromyalgia	25803872	musculoskeletal system disease	DOID:631	M79.7	D005356			We propose a signature of five strikingly downregulated miRNAs (hsa-miR223-3p, hsa-miR451a, hsa-miR338-3p, hsa-miR143-3p and hsa-miR145-5p) to be used as biomarkers of FM. Validation in larger study groups is required before the results can be transferred to the clinic.
tissue_expression_down	hsa-mir-223	Fibromyalgia	25803872	musculoskeletal system disease	DOID:631	M79.7	D005356			We propose a signature of five strikingly downregulated miRNAs (hsa-miR223-3p, hsa-miR451a, hsa-miR338-3p, hsa-miR143-3p and hsa-miR145-5p) to be used as biomarkers of FM. Validation in larger study groups is required before the results can be transferred to the clinic.
tissue_expression_down	hsa-mir-338	Fibromyalgia	25803872	musculoskeletal system disease	DOID:631	M79.7	D005356			We propose a signature of five strikingly downregulated miRNAs (hsa-miR223-3p, hsa-miR451a, hsa-miR338-3p, hsa-miR143-3p and hsa-miR145-5p) to be used as biomarkers of FM. Validation in larger study groups is required before the results can be transferred to the clinic.
tissue_expression_down	hsa-mir-451a	Fibromyalgia	25803872	musculoskeletal system disease	DOID:631	M79.7	D005356			We propose a signature of five strikingly downregulated miRNAs (hsa-miR223-3p, hsa-miR451a, hsa-miR338-3p, hsa-miR143-3p and hsa-miR145-5p) to be used as biomarkers of FM. Validation in larger study groups is required before the results can be transferred to the clinic.
tissue_expression_down	hsa-let-7a-1	Gastric Neoplasms	22374783	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs.
tissue_expression_down	hsa-let-7a-2	Gastric Neoplasms	22374783	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs.
tissue_expression_down	hsa-let-7a-3	Gastric Neoplasms	22374783	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs.
tissue_expression_down	hsa-let-7g	Gastric Neoplasms	20022810	disease of cellular proliferation	DOID:10534	C16	D013274	137215		low expression
tissue_expression_down	hsa-mir-124	Gastric Neoplasms	24805774	disease of cellular proliferation	DOID:10534	C16	D013274	137215		The clinical significance of downregulation of mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p in gastric cancer tumorigenesis.
tissue_expression_down	hsa-mir-124	Gastric Neoplasms	27041578	disease of cellular proliferation	DOID:10534	C16	D013274	137215		In gastric adenocarcinoma cells harboring highly methylated and silenced mir-124 gene loci
tissue_expression_down	hsa-mir-125b	Gastric Neoplasms	25240408	disease of cellular proliferation	DOID:10534	C16	D013274	137215		MiR-125b functions as an oncogene by targeting downregulated PPP1CA and upregulated Rb phosphorylation in gastric cancer. MiR-125b not only promotes cellular proliferation, migration, and invasion in vitro, but also acts as an independent prognostic factor in gastric cancer.
tissue_expression_down	hsa-mir-126	Gastric Neoplasms	26464628	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Our study showed that miR-126, by down-regulation CADM1, enhances migration and invasion in GC cells.
tissue_expression_down	hsa-mir-129-1	Gastric Neoplasms	19148490	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-129: downregulated in undifferentiated gastric cancer
tissue_expression_down	hsa-mir-129-2	Gastric Neoplasms	19148490	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-129: downregulated in undifferentiated gastric cancer
tissue_expression_down	hsa-mir-130a	Gastric Neoplasms	19948396	disease of cellular proliferation	DOID:10534	C16	D013274	137215		different miRNAs have been found to predict sensitivity to anticancer treatment: miR-30c, miR-130a and miR-335 are downregulated in various chemoresistant cell lines, hsa-Let-7g and hsa-miR-181b are strongly associated with response to 5-fluorouracil-based antimetabolite S-1
tissue_expression_down	hsa-mir-133b	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-133b: down-regulated
tissue_expression_down	hsa-mir-135a	Gastric Neoplasms	24465504	disease of cellular proliferation	DOID:10534	C16	D013274	137215		MicroRNA 135a suppresses lymph node metastasis through down-regulation of ROCK1 in early gastric cancer.
tissue_expression_down	hsa-mir-139	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-139-5p: down-regulated
tissue_expression_down	hsa-mir-141	Gastric Neoplasms	26681225	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Our data provide evidence that the downregulation of miR-141 may contribute to the aggressive progression and poor prognosis of human gastric cancer.
tissue_expression_down	hsa-mir-141	Gastric Neoplasms	19363643	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-141: significantly down-regulated in gastric cancer
tissue_expression_down	hsa-mir-145	Gastric Neoplasms	22370644	disease of cellular proliferation	DOID:10534	C16	D013274	137215		The authors demonstrate a stepwise downregulation of miR-145 level in nontumorous gastric mucosa, primary gastric cancers and their secondary metastases.N-cadherin (CDH2) was proved to be a direct target of miR-145
tissue_expression_down	hsa-mir-146a	Gastric Neoplasms	24805774	disease of cellular proliferation	DOID:10534	C16	D013274	137215		The clinical significance of downregulation of mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p in gastric cancer tumorigenesis.
tissue_expression_down	hsa-mir-148a	Gastric Neoplasms	24283384	disease of cellular proliferation	DOID:10534	C16	D013274	137215		MicroRNA-148a is downregulated in gastric cancer, targets MMP7, and indicates tumor invasiveness and poor prognosis.
tissue_expression_down	hsa-mir-148a	Gastric Neoplasms	24515776	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Our results suggest that the suppression of miR-148a may contribute to the down-regulation of MEG3 in gastric cancer by modulation of DNMT-1.
tissue_expression_down	hsa-mir-148a	Gastric Neoplasms	19148490	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-148: downregulated in undifferentiated gastric cancer
tissue_expression_down	hsa-mir-148b	Gastric Neoplasms	19148490	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-148: downregulated in undifferentiated gastric cancer
tissue_expression_down	hsa-mir-148b	Gastric Neoplasms	21205300	disease of cellular proliferation	DOID:10534	C16	D013274	137215		MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation.
tissue_expression_down	hsa-mir-155	Gastric Neoplasms	24805774	disease of cellular proliferation	DOID:10534	C16	D013274	137215		The clinical significance of downregulation of mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p in gastric cancer tumorigenesis.
tissue_expression_down	hsa-mir-155	Gastric Neoplasms	22426647	disease of cellular proliferation	DOID:10534	C16	D013274	137215		microRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis.
tissue_expression_down	hsa-mir-17	Gastric Neoplasms	19598010	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-17-92a cluster; expression lwere significantly lower than non-cancer tissue; may help to clarify the molecular mechanisms; may be a novel diagnostic biomarker
tissue_expression_down	hsa-mir-18a	Gastric Neoplasms	19598010	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-17-92a cluster; expression lwere significantly lower than non-cancer tissue; may help to clarify the molecular mechanisms; may be a novel diagnostic biomarker
tissue_expression_down	hsa-mir-192	Gastric Neoplasms	22205577	disease of cellular proliferation	DOID:10534	C16	D013274	137215		The down-regulation of miR-192 and -215 was demonstrated to be associated with increased tumor sizes and advanced Borrmann type tumors.
tissue_expression_down	hsa-mir-193b	Gastric Neoplasms	25374225	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Association of miR-193b down-regulation and miR-196a up-regulation with clinicopathological features andprognosis in gastric cancer.
tissue_expression_down	hsa-mir-195	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-195: down-regulated
tissue_expression_down	hsa-mir-198	Gastric Neoplasms	26852230	disease of cellular proliferation	DOID:10534	C16	D013274	137215		These findings suggested that miR-198 downregulation may be associated with progression of GC and that this miR may be an independent prognostic marker for GC patients.
tissue_expression_down	hsa-mir-19a	Gastric Neoplasms	19598010	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-17-92a cluster; expression lwere significantly lower than non-cancer tissue; may help to clarify the molecular mechanisms; may be a novel diagnostic biomarker
tissue_expression_down	hsa-mir-205	Gastric Neoplasms	24763883	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Our data suggest that down-regulation of miR-205 may represent an important mechanism for the development of gastric cancer.
tissue_expression_down	hsa-mir-206	Gastric Neoplasms	23751352	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Downregulation of microRNA-206 is a potent prognostic marker for patients with gastric cancer.
tissue_expression_down	hsa-mir-221	Gastric Neoplasms	26214494	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression.
tissue_expression_down	hsa-mir-30c	Gastric Neoplasms	19948396	disease of cellular proliferation	DOID:10534	C16	D013274	137215		different miRNAs have been found to predict sensitivity to anticancer treatment: miR-30c, miR-130a and miR-335 are downregulated in various chemoresistant cell lines, hsa-Let-7g and hsa-miR-181b are strongly associated with response to 5-fluorouracil-based antimetabolite S-1
tissue_expression_down	hsa-mir-31	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-31: down-regulated
tissue_expression_down	hsa-mir-328	Gastric Neoplasms	25479940	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-328 downregulation and de novo expression of CD44v9 occurred in H. pylori-infected gastric mucosa adjacent to gastric cancer compared with gastric mucosa not infected with H. pylori adjacent to gastric cancer. CD44v9-overexpressing cells are known to acquire reactive oxygen species resistance; thus, these cells may avoid cell death caused by various stress inducers, which may be linked to the origin of gastric cancer development.
tissue_expression_down	hsa-mir-335	Gastric Neoplasms	24805774	disease of cellular proliferation	DOID:10534	C16	D013274	137215		The clinical significance of downregulation of mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p in gastric cancer tumorigenesis.
tissue_expression_down	hsa-mir-335	Gastric Neoplasms	19948396	disease of cellular proliferation	DOID:10534	C16	D013274	137215		different miRNAs have been found to predict sensitivity to anticancer treatment: miR-30c, miR-130a and miR-335 are downregulated in various chemoresistant cell lines, hsa-Let-7g and hsa-miR-181b are strongly associated with response to 5-fluorouracil-based antimetabolite S-1
tissue_expression_down	hsa-mir-34a	Gastric Neoplasms	26415802	disease of cellular proliferation	DOID:10534	C16	D013274	137215		The results reinforce the critical role for the down-regulated miR-34a expression in gastric cancer and suggest that miR-34a could be a prognostic indicator for this disease.
tissue_expression_down	hsa-mir-370	Gastric Neoplasms	21666718	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Overexpression of miR-370 and downregulation of its novel target TGFbeta-RII contribute to the progression of gastric carcinoma.
tissue_expression_down	hsa-mir-378a	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-378: down-regulated
tissue_expression_down	hsa-mir-433	Gastric Neoplasms	20022810	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Low expression
tissue_expression_down	hsa-mir-449a	Gastric Neoplasms	21418558	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-449 inhibits cell proliferation and is down-regulated in gastric cancer.
tissue_expression_down	hsa-mir-449b	Gastric Neoplasms	21418558	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-449 inhibits cell proliferation and is down-regulated in gastric cancer.
tissue_expression_down	hsa-mir-449c	Gastric Neoplasms	21418558	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-449 inhibits cell proliferation and is down-regulated in gastric cancer.
tissue_expression_down	hsa-mir-497	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-497: down-regulated
tissue_expression_down	hsa-mir-504	Gastric Neoplasms	25015107	disease of cellular proliferation	DOID:10534	C16	D013274	137215		TFF1 activates p53 through down-regulation of miR-504 in gastric cancer.
tissue_expression_down	hsa-mir-573	Gastric Neoplasms	26054975	disease of cellular proliferation	DOID:10534	C16	D013274	137215		TSPAN1 functions as an oncogene in gastric cancer and is downregulated by miR-573.
tissue_expression_down	hsa-mir-760	Gastric Neoplasms	24097871	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Histone mRNA was upregulated, whereas miR-760 was downregulated in the bone marrow and primary tumor of advanced gastric cancer patients, suggesting that the histone mRNA/miR-760 axis had a crucial role in the development of gastric cancer.
tissue_expression_down	hsa-let-7g	Gastrointestinal Neoplasms	21293479			D37.9	D005770			In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7.
tissue_expression_down	hsa-mir-126	Gastrointestinal Neoplasms	21293479			D37.9	D005770			In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7.
tissue_expression_down	hsa-mir-146a	Gastrointestinal Neoplasms	21347720			D37.9	D005770			MicroRNA-146a is down-regulated in gastric cancer and regulates cell proliferation and apoptosis.
tissue_expression_down	hsa-mir-148a	Gastrointestinal Neoplasms	20422307			D37.9	D005770			MiR-148a:MiR-148a and miR-152 may be involved in the carcinogenesis of gastrointestinal cancers and might be potential biomarkers
tissue_expression_down	hsa-mir-152	Gastrointestinal Neoplasms	20422307			D37.9	D005770			MiR-152:MiR-148a and miR-152 may be involved in the carcinogenesis of gastrointestinal cancers and might be potential biomarkers
tissue_expression_down	hsa-mir-196a-1	Gastrointestinal Neoplasms	21293479			D37.9	D005770			In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7.
tissue_expression_down	hsa-mir-196a-2	Gastrointestinal Neoplasms	21293479			D37.9	D005770			In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7.
tissue_expression_down	hsa-mir-200a	Gastrointestinal Neoplasms	21293479			D37.9	D005770			In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7.
tissue_expression_down	hsa-mir-200a	Gastrointestinal Neoplasms	23456798			D37.9	D005770			It was noteworthy that miR-200a was significantly down-regulated in gastric adenocarcinoma samples (P = .04) but was up-regulated in esophageal adenocarcinoma samples (P = .001). 
tissue_expression_down	hsa-mir-200b	Gastrointestinal Neoplasms	21293479			D37.9	D005770			In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7.
tissue_expression_down	hsa-mir-200c	Gastrointestinal Neoplasms	21293479			D37.9	D005770			In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7.
tissue_expression_down	hsa-mir-218	Gastrointestinal Neoplasms	19890957			D37.9	D005770			miR-218 expression was reduced significantly in gastric cancer tissues, in H. pylori-infected gastric mucosa, and in H. pylori-infected AGS cells.
tissue_expression_down	hsa-mir-218	Gastrointestinal Neoplasms	20510072			D37.9	D005770			miR-218 expression is reduced in gastric cancer. miR-218 may function as a tumor suppressor in gastric carcinoma.
tissue_expression_down	hsa-mir-221	Gastrointestinal Neoplasms	21132270			D37.9	D005770			Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors
tissue_expression_down	hsa-mir-222	Gastrointestinal Neoplasms	21132270			D37.9	D005770			Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors
tissue_expression_down	hsa-mir-31	Gastrointestinal Neoplasms	21293479			D37.9	D005770			In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7.
tissue_expression_down	hsa-mir-338	Gastrointestinal Neoplasms	21293479			D37.9	D005770			In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7.
tissue_expression_down	hsa-mir-433	Gastrointestinal Neoplasms	19531230			D37.9	D005770			Down-regulated miR-9 and miR-433 in human gastric carcinoma.
tissue_expression_down	hsa-mir-7-1	Gastrointestinal Neoplasms	21293479			D37.9	D005770			In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7.
tissue_expression_down	hsa-mir-7-2	Gastrointestinal Neoplasms	21293479			D37.9	D005770			In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7.
tissue_expression_down	hsa-mir-7-3	Gastrointestinal Neoplasms	21293479			D37.9	D005770			In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7.
tissue_expression_down	hsa-mir-9	Gastrointestinal Neoplasms	19531230			D37.9	D005770			Down-regulated miR-9 and miR-433 in human gastric carcinoma.
tissue_expression_down	hsa-mir-98	Gastrointestinal Neoplasms	21293479			D37.9	D005770			In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7.
tissue_expression_down	hsa-let-7a-1	Glioblastoma	22074483				D005909		HP:0100843	Significantly deregulated miRNAs were miR-3163 (fold change 2.0, p = 0.05), miR-539 (fold change 0.5, p = 0.001), miR-1305 (fold change 0.5, p = 0.05), miR-1260 (fold change 0.5, p = 0.03) and let-7a (fold change 0.3, p = 0.02) after temozolomide treatment.
tissue_expression_down	hsa-let-7a-2	Glioblastoma	22074483				D005909		HP:0100843	Significantly deregulated miRNAs were miR-3163 (fold change 2.0, p = 0.05), miR-539 (fold change 0.5, p = 0.001), miR-1305 (fold change 0.5, p = 0.05), miR-1260 (fold change 0.5, p = 0.03) and let-7a (fold change 0.3, p = 0.02) after temozolomide treatment.
tissue_expression_down	hsa-let-7a-3	Glioblastoma	22074483				D005909		HP:0100843	Significantly deregulated miRNAs were miR-3163 (fold change 2.0, p = 0.05), miR-539 (fold change 0.5, p = 0.001), miR-1305 (fold change 0.5, p = 0.05), miR-1260 (fold change 0.5, p = 0.03) and let-7a (fold change 0.3, p = 0.02) after temozolomide treatment.
tissue_expression_down	hsa-mir-124	Glioblastoma	23817964				D005909		HP:0100843	MiR-124 inhibits the growth of glioblastoma through the downregulation of SOS1.
tissue_expression_down	hsa-mir-124	Glioblastoma	22929615				D005909		HP:0100843	We tested two predicted proneural drivers, miR-124 and miR-132, both underexpressed in proneural tumors, by overexpression in neurospheres and observed a partial reversal of corresponding tumor expression changes.
tissue_expression_down	hsa-mir-124	Glioblastoma	29559295				D005909		HP:0100843	In our microarray data, lower expression of miR-219-5p, miR-124, and miR-128 and higher expression of miR-21 was observed in GBM compared with the peripheral region, similar to the results of previous reports
tissue_expression_down	hsa-mir-124-1	Glioblastoma	21912681				D005909		HP:0100843	Significantly down-regulated in glioblastomas.
tissue_expression_down	hsa-mir-124-2	Glioblastoma	21196113				D005909		HP:0100843	miR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion.
tissue_expression_down	hsa-mir-124-2	Glioblastoma	21912681				D005909		HP:0100843	Significantly down-regulated in glioblastomas.
tissue_expression_down	hsa-mir-124-3	Glioblastoma	21912681				D005909		HP:0100843	Significantly down-regulated in glioblastomas.
tissue_expression_down	hsa-mir-126	Glioblastoma	27920004				D005909		HP:0100843	Down-regulation of MicroRNA-126 in Glioblastoma and its Correlation with Patient Prognosis: A Pilot Study.
tissue_expression_down	hsa-mir-1260a	Glioblastoma	22074483				D005909		HP:0100843	Significantly deregulated miRNAs were miR-3163 (fold change 2.0, p = 0.05), miR-539 (fold change 0.5, p = 0.001), miR-1305 (fold change 0.5, p = 0.05), miR-1260 (fold change 0.5, p = 0.03) and let-7a (fold change 0.3, p = 0.02) after temozolomide treatment.
tissue_expression_down	hsa-mir-128	Glioblastoma	27526390				D005909		HP:0100843	The microRNA-128 expression levels were down-regulated in low-grade glioma tissue
tissue_expression_down	hsa-mir-128	Glioblastoma	29559295				D005909		HP:0100843	In our microarray data, lower expression of miR-219-5p, miR-124, and miR-128 and higher expression of miR-21 was observed in GBM compared with the peripheral region, similar to the results of previous reports
tissue_expression_down	hsa-mir-128-1	Glioblastoma	19941032				D005909		HP:0100843	miR-128:Micro-RNA-128 (miRNA-128) down-regulation in glioblastoma targets ARP5 (ANGPTL6), Bmi-1 and E2F-3a, key regulators of brain cell proliferation
tissue_expression_down	hsa-mir-128-1	Glioblastoma	21912681				D005909		HP:0100843	Significantly down-regulated in glioblastomas.
tissue_expression_down	hsa-mir-128-1	Glioblastoma	22922228				D005909		HP:0100843	Platelet-derived growth factor-B (PDGF-B), a potent angiogenic growth factor involved in GBM development and progression, promotes downregulation of pro-oncogenic (miR-21) and anti-oncogenic (miR-128) miRNAs in GBM pathology.
tissue_expression_down	hsa-mir-128-2	Glioblastoma	19941032				D005909		HP:0100843	miR-128:Micro-RNA-128 (miRNA-128) down-regulation in glioblastoma targets ARP5 (ANGPTL6), Bmi-1 and E2F-3a, key regulators of brain cell proliferation
tissue_expression_down	hsa-mir-128-2	Glioblastoma	21912681				D005909		HP:0100843	Significantly down-regulated in glioblastomas.
tissue_expression_down	hsa-mir-128-2	Glioblastoma	22922228				D005909		HP:0100843	Platelet-derived growth factor-B (PDGF-B), a potent angiogenic growth factor involved in GBM development and progression, promotes downregulation of pro-oncogenic (miR-21) and anti-oncogenic (miR-128) miRNAs in GBM pathology.
tissue_expression_down	hsa-mir-1305	Glioblastoma	22074483				D005909		HP:0100843	Significantly deregulated miRNAs were miR-3163 (fold change 2.0, p = 0.05), miR-539 (fold change 0.5, p = 0.001), miR-1305 (fold change 0.5, p = 0.05), miR-1260 (fold change 0.5, p = 0.03) and let-7a (fold change 0.3, p = 0.02) after temozolomide treatment.
tissue_expression_down	hsa-mir-132	Glioblastoma	22929615				D005909		HP:0100843	We tested two predicted proneural drivers, miR-124 and miR-132, both underexpressed in proneural tumors, by overexpression in neurospheres and observed a partial reversal of corresponding tumor expression changes.
tissue_expression_down	hsa-mir-137	Glioblastoma	22406049				D005909		HP:0100843	miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2.
tissue_expression_down	hsa-mir-137	Glioblastoma	24412320				D005909		HP:0100843	We found gradual increase in miR-21 and miR-23a levels in all tumor grades whereas miR-7 and miR-137 were significantly down-regulated depending on the glioma grade.
tissue_expression_down	hsa-mir-139	Glioblastoma	21912681				D005909		HP:0100843	Significantly down-regulated in glioblastomas.
tissue_expression_down	hsa-mir-143	Glioblastoma	21211035				D005909		HP:0100843	down regulation of miR-143, -145, -253-5p and miR-452 by SOX2
tissue_expression_down	hsa-mir-145	Glioblastoma	21211035				D005909		HP:0100843	down regulation of miR-143, -145, -253-5p and miR-452 by SOX2
tissue_expression_down	hsa-mir-145	Glioblastoma	24531649				D005909		HP:0100843	Dendrosomal curcumin nanoformulation downregulates pluripotency genes via miR-145 activation in U87MG glioblastoma cells.
tissue_expression_down	hsa-mir-145	Glioblastoma	26026080				D005909		HP:0100843	The elevated miR-145 present in invasive glioblastoma cells (IM3 cells) targets and down-regulated srGAP1, thereby allowing downstream G-proteins to remain in their active state and promote the observed invasive phenotype.
tissue_expression_down	hsa-mir-181a	Glioblastoma	27176932				D005909		HP:0100843	miR-181a is down-regulated in GBM patients
tissue_expression_down	hsa-mir-181c	Glioblastoma	25494473				D005909		HP:0100843	miR-181c can be considered a valuable indicator for the outcome of GBM patients. miR-181c acts as a tumor suppressor that attenuates proliferation, invasion, and self-renewal capacities by downregulation of Notch2 in glioma cells.
tissue_expression_down	hsa-mir-203	Glioblastoma	25871397				D005909		HP:0100843	MiR-203 downregulation is responsible for chemoresistance in human glioblastoma by promoting epithelial-mesenchymal transition via SNAI2.
tissue_expression_down	hsa-mir-20a	Glioblastoma	21483847				D005909		HP:0100843	miR-20a upregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma.
tissue_expression_down	hsa-mir-21	Glioblastoma	22922228				D005909		HP:0100843	Platelet-derived growth factor-B (PDGF-B), a potent angiogenic growth factor involved in GBM development and progression, promotes downregulation of pro-oncogenic (miR-21) and anti-oncogenic (miR-128) miRNAs in GBM pathology.
tissue_expression_down	hsa-mir-21	Glioblastoma	25991372				D005909		HP:0100843	Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/β-catenin signaling in glioblastoma.
tissue_expression_down	hsa-mir-219	Glioblastoma	29559295				D005909		HP:0100843	In our microarray data, lower expression of miR-219-5p, miR-124, and miR-128 and higher expression of miR-21 was observed in GBM compared with the peripheral region, similar to the results of previous reports
tissue_expression_down	hsa-mir-221	Glioblastoma	21483847				D005909		HP:0100843	miR-221 downregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma.
tissue_expression_down	hsa-mir-222	Glioblastoma	21483847				D005909		HP:0100843	miR-222 downregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma.
tissue_expression_down	hsa-mir-222	Glioblastoma	24412053				D005909		HP:0100843	The analysis  of 14 validated miRNA expression in the 60 glioblastomas, using three different non-neoplastic references as controls, revealed a putative miRNA signature: mir-10b and miR-21 were up-regulated, while miR-7, miR-31, miR-101, miR-137, miR-222 and miR-330 were down-regulated in glioblastomas.
tissue_expression_down	hsa-mir-31	Glioblastoma	21483847				D005909		HP:0100843	miR-31 downregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma.
tissue_expression_down	hsa-mir-328	Glioblastoma	23077581				D005909		HP:0100843	MiR-328 expression is decreased in high-grade gliomas and is associated with worse survival in primary glioblastoma
tissue_expression_down	hsa-mir-34c	Glioblastoma	24179539				D005909		HP:0100843	It was demonstrated that miR-34c-3p and miR-34c-5p were downregulated in gliomas, by performing qPCR on tumor tissues from glioma patients and glioma cell lines, compared with normal brain tissues and a normal glial cell line.
tissue_expression_down	hsa-mir-451	Glioblastoma	20647762				D005909		HP:0100843	We initially identified miR-451 due to its downregulation in a glioma cell migration assay.
tissue_expression_down	hsa-mir-452	Glioblastoma	21211035				D005909		HP:0100843	down regulation of miR-143, -145, -253-5p and miR-452 by SOX2
tissue_expression_down	hsa-mir-539	Glioblastoma	22074483				D005909		HP:0100843	Significantly deregulated miRNAs were miR-3163 (fold change 2.0, p = 0.05), miR-539 (fold change 0.5, p = 0.001), miR-1305 (fold change 0.5, p = 0.05), miR-1260 (fold change 0.5, p = 0.03) and let-7a (fold change 0.3, p = 0.02) after temozolomide treatment.
tissue_expression_down	hsa-mir-7	Glioblastoma	25027403				D005909		HP:0100843	MiR-7-5p is frequently downregulated in glioblastoma microvasculature and inhibits vascular endothelial cell proliferation by targeting RAF1.
tissue_expression_down	hsa-mir-7-1	Glioblastoma	21912681				D005909		HP:0100843	Significantly down-regulated in glioblastomas.
tissue_expression_down	hsa-mir-7-2	Glioblastoma	21912681				D005909		HP:0100843	Significantly down-regulated in glioblastomas.
tissue_expression_down	hsa-mir-7-3	Glioblastoma	21912681				D005909		HP:0100843	Significantly down-regulated in glioblastomas.
tissue_expression_down	hsa-mir-873	Glioblastoma	21912681				D005909		HP:0100843	Significantly down-regulated in glioblastomas.
tissue_expression_down	hsa-mir-95	Glioblastoma	21912681				D005909		HP:0100843	Significantly down-regulated in glioblastomas.
tissue_expression_down	hsa-mir-107	Glioma	23220650	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	P53-induced microRNA-107 inhibits proliferation of glioma cells and down-regulates the expression of CDK6 and Notch-2
tissue_expression_down	hsa-mir-124	Glioma	25112530	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Downregulation of microRNA-124 predicts poor prognosis in glioma patients.
tissue_expression_down	hsa-mir-124	Glioma	28060761	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Sensitivity and specificity analysis indicated miR-15a, miR-16, miR-21, miR-23a, and miR-9 were up-regulated, while miR-124 was down-regulated in glioma
tissue_expression_down	hsa-mir-132	Glioma	27522003	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	The expression of miR-132 was low in human glioma tissues,  and the downregulated expression was associated with advanced glioma grades.
tissue_expression_down	hsa-mir-154	Glioma	27417886	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Conclusions These results suggest that miR-154 downregulation may be involved in glioma formation and progression, and that miR-154 might serve as a potential prognostic biomarker for patients with this disease.
tissue_expression_down	hsa-mir-16	Glioma	26082082	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Osthole suppresses the proliferation and accelerates the apoptosis of human glioma cells via the upregulation of microRNA-16 and downregulation of MMP-9.
tissue_expression_down	hsa-mir-16	Glioma	25954855	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Paeoniflorin inhibits proliferation and induces apoptosis of human glioma cells via microRNA-16 upregulation and matrix metalloproteinase-9 downregulation.
tissue_expression_down	hsa-mir-200b	Glioma	24559637	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	These findings prove that the decreased expression of miR-200b may be associated with malignant tumor progression and poor prognosis in patients with gliomas, suggesting the potential role of miR-200b in glioma management. miR-200b may be a novel and valuable signature for predicting the clinical outcome of patients with gliomas.
tissue_expression_down	hsa-mir-200b	Glioma	27374173	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR-200b was found to be down-regulated in glioma samples
tissue_expression_down	hsa-mir-218	Glioma	25773834	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Our results indicate that miR-218 is downregulated in gliomas and that its status might be a potential valuable biomarker for glioma patients.
tissue_expression_down	hsa-mir-218-1	Glioma	22088371	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	The expression level of miR-218 is an important reference indicator for the assessment of the grade of gliomas. An aberrant decrease of its expression may lead to an increase of the CDK6 expression and proliferative activity of giloma cells. Introducing exogenous miR-218 may effectively down-regulate the CDK6 expression, inhibit cell proliferation and induce apoptosis of malignant giloma cells.
tissue_expression_down	hsa-mir-218-2	Glioma	22088371	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	The expression level of miR-218 is an important reference indicator for the assessment of the grade of gliomas. An aberrant decrease of its expression may lead to an increase of the CDK6 expression and proliferative activity of giloma cells. Introducing exogenous miR-218 may effectively down-regulate the CDK6 expression, inhibit cell proliferation and induce apoptosis of malignant giloma cells.
tissue_expression_down	hsa-mir-221	Glioma	24589600	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	MiR-221 regulates the expression of EMT-related genes through down-regulation of PTEN and activation of PI3-K/Akt signaling.
tissue_expression_down	hsa-mir-26a	Glioma	29658967	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	low expression  of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-527 in low-grade glioma
tissue_expression_down	hsa-mir-31	Glioma	24380686	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Concomitant microRNA-31 downregulation and radixin upregulation predicts advanced tumor progression and unfavorable prognosis in patients with gliomas.
tissue_expression_down	hsa-mir-320d	Glioma	27862991	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Downregulation of MicroRNA-320d predicts poor overall survival and promotes the growth and invasive abilities in glioma.
tissue_expression_down	hsa-mir-326	Glioma	23292865	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Down-regulation of miR-326 may have potential value for predicting clinical outcomes in glioma patients with high pathological grades, suggesting that miR-326 is an important candidate tumor suppressor, and its down-regulated expression may contribute to glioma progression
tissue_expression_down	hsa-mir-367	Glioma	26261539	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Our results suggested that both high-miR-196a and low-miR-367 expression may be associated with aggressive progression and unfavorable clinical outcome in glioma patients. And combination of high-miR-196a and low-miR-367 expression may be a novel biomarker in identifying a poor prognosis group of high-grade glioma.
tissue_expression_down	hsa-mir-375	Glioma	23103713	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Correlation of microRNA-375 downregulation with unfavorable clinical outcome of patients with glioma
tissue_expression_down	hsa-mir-378	Glioma	26261592	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Decreased expression of miR-378 correlates with tumor invasiveness and poor prognosis of patients with glioma.
tissue_expression_down	hsa-mir-494	Glioma	26153143	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Compound 331 selectively induces glioma cell death by upregulating miR-494 and downregulating CDC20.
tissue_expression_down	hsa-mir-497	Glioma	27569294	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Reduced expression of microRNA-497 is associated with greater angiogenesis and poor prognosis in human gliomas.
tissue_expression_down	hsa-mir-504	Glioma	25755767	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Downregulation of microRNA-504 is associated with poor prognosis in high-grade glioma.
tissue_expression_down	hsa-mir-544a	Glioma	23205130	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma
tissue_expression_down	hsa-mir-544b	Glioma	23205130	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma
tissue_expression_down	hsa-mir-9	Glioma	26082082	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Osthole suppresses the proliferation and accelerates the apoptosis of human glioma cells via the upregulation of microRNA-16 and downregulation of MMP-9.
tissue_expression_down	hsa-mir-26a	Glomerulonephritis	25329154	urinary system disease	DOID:2921	N05	D005921	305800	HP:0000099	Decreased miR-26a expression correlates with the progression of podocyte injury in autoimmune glomerulonephritis.
tissue_expression_down	hsa-mir-372	Habitual Abortion	26879955			N96	D000026			hsa-miR-1 and -372 were significantly lower compared to normal pregnancy.
tissue_expression_down	hsa-let-7d	Head And Neck Neoplasms	19179615	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	let-7d: show lower expression levels relative to normal adjacent tissue
tissue_expression_down	hsa-mir-100	Head And Neck Neoplasms	21560177	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_down	hsa-mir-100	Head And Neck Neoplasms	22425712	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	down-regulation
tissue_expression_down	hsa-mir-101-1	Head And Neck Neoplasms	21637912	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	hsa-mir-101 was downregulated compared with normal tissue.
tissue_expression_down	hsa-mir-101-2	Head And Neck Neoplasms	21637912	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	hsa-mir-101 was downregulated compared with normal tissue.
tissue_expression_down	hsa-mir-107	Head And Neck Neoplasms	22158047	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	microRNA-107 functions as a candidate tumor-suppressor gene in head and neck squamous cell carcinoma by downregulation of protein kinase C
tissue_expression_down	hsa-mir-1-1	Head And Neck Neoplasms	19179615	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-1: show lower expression levels relative to normal adjacent tissue
tissue_expression_down	hsa-mir-1-2	Head And Neck Neoplasms	19179615	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-1: show lower expression levels relative to normal adjacent tissue
tissue_expression_down	hsa-mir-130a	Head And Neck Neoplasms	21560177	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_down	hsa-mir-133a-1	Head And Neck Neoplasms	19179615	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-133a: show lower expression levels relative to normal adjacent tissue
tissue_expression_down	hsa-mir-133a-2	Head And Neck Neoplasms	19179615	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-133a: show lower expression levels relative to normal adjacent tissue
tissue_expression_down	hsa-mir-141	Head And Neck Neoplasms	21637912	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	hsa-mir-141 was downregulated compared with normal tissue.
tissue_expression_down	hsa-mir-197	Head And Neck Neoplasms	21560177	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_down	hsa-mir-205	Head And Neck Neoplasms	19179615	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-205: show lower expression levels relative to normal adjacent tissue
tissue_expression_down	hsa-mir-26b	Head And Neck Neoplasms	22811001	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	In addition, the expression levels of miR-21 and miR-26b were both reduced in post-operative HNSCC patients with good prognosis.
tissue_expression_down	hsa-mir-375	Head And Neck Neoplasms	22234174	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Low-Level Expression of miR-375 Correlates with Poor Outcome and Metastasis While Altering the Invasive Properties of Head and Neck Squamous Cell Carcinomas.
tissue_expression_down	hsa-mir-375	Head And Neck Neoplasms	22425712	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	down-regulation
tissue_expression_down	hsa-mir-499a	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-499: underexpressed
tissue_expression_down	hsa-mir-95	Head And Neck Neoplasms	21637912	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	hsa-mir-95 was downregulated compared with normal tissue.
tissue_expression_down	hsa-mir-99a	Head And Neck Neoplasms	22425712	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	down-regulation
tissue_expression_down	hsa-mir-107	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-107	Heart Failure	20484156			I50	D006331		HP:0001635	miR-107: downregulated
tissue_expression_down	hsa-mir-1-1	Heart Failure	19059107			I50	D006331		HP:0001635	miR-1: decreased expression
tissue_expression_down	hsa-mir-1-2	Heart Failure	19059107			I50	D006331		HP:0001635	miR-1: decreased expression
tissue_expression_down	hsa-mir-130b	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-133a-1	Heart Failure	19059107			I50	D006331		HP:0001635	miR-133a: decreased expression
tissue_expression_down	hsa-mir-133a-2	Heart Failure	19059107			I50	D006331		HP:0001635	miR-133a: decreased expression
tissue_expression_down	hsa-mir-133b	Heart Failure	19059107			I50	D006331		HP:0001635	miR-133b: decreased expression
tissue_expression_down	hsa-mir-135a-1	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-135a-2	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-136	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-139	Heart Failure	20484156			I50	D006331		HP:0001635	miR-139: downregulated
tissue_expression_down	hsa-mir-142	Heart Failure	20484156			I50	D006331		HP:0001635	miR-142-5p: downregulated
tissue_expression_down	hsa-mir-148a	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-150	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-15b	Heart Failure	22093502			I50	D006331		HP:0001635	The real-time PCR confirmed lower expression in LV recovery patients for 4 miRs (15b, -1.5-fold; 23a, -2.2-fold; 26a, -1.4-fold; and 195, -1.8-fold; all p < 0.04 vs. VAD dependent). The validation cohort similarly showed lower miRs expression in LV recovery patients (23a, -1.8-fold; and 195, -1.5-fold; both p < 0.03). Furthermore, miR 23a and 195 expression in nonfailing hearts was similar to LV recovery patients (both p < 0.04 vs. VAD dependent).
tissue_expression_down	hsa-mir-16-1	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-16-2	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-17	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-182	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-186	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-186	Heart Failure	28233577			I50	D006331		HP:0001635	TNFα-induced downregulation of microRNA-186 contributes to apoptosis in rat primary cardiomyocytes.
tissue_expression_down	hsa-mir-192	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-195	Heart Failure	22093502			I50	D006331		HP:0001635	The real-time PCR confirmed lower expression in LV recovery patients for 4 miRs (15b, -1.5-fold; 23a, -2.2-fold; 26a, -1.4-fold; and 195, -1.8-fold; all p < 0.04 vs. VAD dependent). The validation cohort similarly showed lower miRs expression in LV recovery patients (23a, -1.8-fold; and 195, -1.5-fold; both p < 0.03). Furthermore, miR 23a and 195 expression in nonfailing hearts was similar to LV recovery patients (both p < 0.04 vs. VAD dependent).
tissue_expression_down	hsa-mir-19b-1	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-19b-2	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-218-1	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-218-2	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-22	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-23a	Heart Failure	22093502			I50	D006331		HP:0001635	The real-time PCR confirmed lower expression in LV recovery patients for 4 miRs (15b, -1.5-fold; 23a, -2.2-fold; 26a, -1.4-fold; and 195, -1.8-fold; all p < 0.04 vs. VAD dependent). The validation cohort similarly showed lower miRs expression in LV recovery patients (23a, -1.8-fold; and 195, -1.5-fold; both p < 0.03). Furthermore, miR 23a and 195 expression in nonfailing hearts was similar to LV recovery patients (both p < 0.04 vs. VAD dependent).
tissue_expression_down	hsa-mir-23b	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-24-1	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-24-2	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-26a-1	Heart Failure	22093502			I50	D006331		HP:0001635	The real-time PCR confirmed lower expression in LV recovery patients for 4 miRs (15b, -1.5-fold; 23a, -2.2-fold; 26a, -1.4-fold; and 195, -1.8-fold; all p < 0.04 vs. VAD dependent). The validation cohort similarly showed lower miRs expression in LV recovery patients (23a, -1.8-fold; and 195, -1.5-fold; both p < 0.03). Furthermore, miR 23a and 195 expression in nonfailing hearts was similar to LV recovery patients (both p < 0.04 vs. VAD dependent).
tissue_expression_down	hsa-mir-26a-2	Heart Failure	22093502			I50	D006331		HP:0001635	The real-time PCR confirmed lower expression in LV recovery patients for 4 miRs (15b, -1.5-fold; 23a, -2.2-fold; 26a, -1.4-fold; and 195, -1.8-fold; all p < 0.04 vs. VAD dependent). The validation cohort similarly showed lower miRs expression in LV recovery patients (23a, -1.8-fold; and 195, -1.5-fold; both p < 0.03). Furthermore, miR 23a and 195 expression in nonfailing hearts was similar to LV recovery patients (both p < 0.04 vs. VAD dependent).
tissue_expression_down	hsa-mir-27a	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-296	Heart Failure	21690488			I50	D006331		HP:0001635	The absolute expression levels of hcmv-miR-UL112, miR-296-5p, and let-7e were further determined in 127 patients and 67 control subjects (fold changes are 2.5, 0.5, and 1.7 respectively; all P<0.0001).
tissue_expression_down	hsa-mir-299	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-302b	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-302c	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-30a	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-30b	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-30c-1	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-30c-2	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-30e	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-325	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-339	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-342	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-424	Heart Failure	27072074			I50	D006331		HP:0001635	In coronary sinus samples, the microRNAs miR-16-5p, miR-27a-3p, miR-27b-3p, miR-29b-3p, miR-29c-3p, miR-30e-5p, miR-92a-3p, miR-125b-5p, miR-140-5p, miR-195-5p, miR-424-5p, and miR-451a were significantly down-regulated, and let-7a-5p, let-7c-5p, let-7e-5p, miR-23b-3p, miR-107, miR-155-5p, miR-181a-5p, miR-181b-5p and miR-320a were up-regulated in heart failure.
tissue_expression_down	hsa-mir-452	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-494	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-497	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-499	Heart Failure	24495916			I50	D006331		HP:0001635	In HHcy, the expression of NMDAR1, DNMT1, and matrix metalloproteinase 9 increased with increase in H3K9 acetylation, while HDAC1, miR-133a, and miR-499 decreased in cardiomyocytes.
tissue_expression_down	hsa-mir-499a	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-507	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-512-1	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-512-2	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-515-1	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-515-2	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-520a	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-520b	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-520d	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-520e	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-520f	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-520g	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-520h	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-523	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-526a-1	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-526a-2	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-526b	Heart Failure	17606841			I50	D006331		HP:0001635	downregulated
tissue_expression_down	hsa-mir-15a	Hepatitis B Virus Infection	19187610	disease by infectious agent	DOID:2043	B16/18	D006509	610424		miR-15a: down-regulated
tissue_expression_down	hsa-mir-185	Hepatitis B Virus Infection	27190255	disease by infectious agent	DOID:2043	B16/18	D006509	610424		two down-regulated microRNAs including miR-185-5p and miR-186-5p were correlated in both in vitro and in vivo studies
tissue_expression_down	hsa-mir-186	Hepatitis B Virus Infection	27190255	disease by infectious agent	DOID:2043	B16/18	D006509	610424		two down-regulated microRNAs including miR-185-5p and miR-186-5p were correlated in both in vitro and in vivo studies.
tissue_expression_down	hsa-mir-221	Hepatitis B Virus Infection	21876625	disease by infectious agent	DOID:2043	B16/18	D006509	610424		downregulated in acute HBV infection, normally expressed in chronic HBV infection, and upregulated in HCC
tissue_expression_down	hsa-mir-1-1	Hepatitis C Virus Infection	19360909	disease by infectious agent	DOID:1883	B19.2	D006526	609532		miR-1: down-regulated
tissue_expression_down	hsa-mir-1-2	Hepatitis C Virus Infection	19360909	disease by infectious agent	DOID:1883	B19.2	D006526	609532		miR-1: down-regulated
tissue_expression_down	hsa-mir-124	Hepatitis C Virus Infection	27753084	disease by infectious agent	DOID:1883	B19.2	D006526	609532		Decline of miR-124 in myeloid cells promotes regulatory T-cell development in hepatitis C virus infection.
tissue_expression_down	hsa-mir-126	Hepatitis C Virus Infection	16331254	disease by infectious agent	DOID:1883	B19.2	D006526	609532		downregulated
tissue_expression_down	hsa-mir-143	Hepatitis C Virus Infection	16331254	disease by infectious agent	DOID:1883	B19.2	D006526	609532		downregulated
tissue_expression_down	hsa-mir-16	Hepatitis C Virus Infection	26071245	disease by infectious agent	DOID:1883	B19.2	D006526	609532		Increased miR-16 expression induced by hepatitis C virus infection promotes liver fibrosis through downregulation of hepatocyte growth factor and Smad7.
tissue_expression_down	hsa-mir-196a-1	Hepatitis C Virus Infection	19360909	disease by infectious agent	DOID:1883	B19.2	D006526	609532		miR-196: down-regulated
tissue_expression_down	hsa-mir-196a-2	Hepatitis C Virus Infection	19360909	disease by infectious agent	DOID:1883	B19.2	D006526	609532		miR-196: down-regulated
tissue_expression_down	hsa-mir-196b	Hepatitis C Virus Infection	19360909	disease by infectious agent	DOID:1883	B19.2	D006526	609532		miR-196: down-regulated
tissue_expression_down	hsa-mir-199a-1	Hepatitis C Virus Infection	16331254	disease by infectious agent	DOID:1883	B19.2	D006526	609532		downregulated
tissue_expression_down	hsa-mir-199a-2	Hepatitis C Virus Infection	16331254	disease by infectious agent	DOID:1883	B19.2	D006526	609532		downregulated
tissue_expression_down	hsa-mir-28	Hepatitis C Virus Infection	16331254	disease by infectious agent	DOID:1883	B19.2	D006526	609532		downregulated
tissue_expression_down	hsa-mir-296	Hepatitis C Virus Infection	19360909	disease by infectious agent	DOID:1883	B19.2	D006526	609532		miR-296: down-regulated
tissue_expression_down	hsa-mir-30a	Hepatitis C Virus Infection	19360909	disease by infectious agent	DOID:1883	B19.2	D006526	609532		miR-30: down-regulated
tissue_expression_down	hsa-mir-30b	Hepatitis C Virus Infection	19360909	disease by infectious agent	DOID:1883	B19.2	D006526	609532		miR-30: down-regulated
tissue_expression_down	hsa-mir-30c-1	Hepatitis C Virus Infection	19360909	disease by infectious agent	DOID:1883	B19.2	D006526	609532		miR-30: down-regulated
tissue_expression_down	hsa-mir-30c-2	Hepatitis C Virus Infection	19360909	disease by infectious agent	DOID:1883	B19.2	D006526	609532		miR-30: down-regulated
tissue_expression_down	hsa-mir-30d	Hepatitis C Virus Infection	19360909	disease by infectious agent	DOID:1883	B19.2	D006526	609532		miR-30: down-regulated
tissue_expression_down	hsa-mir-342	Hepatitis C Virus Infection	16331254	disease by infectious agent	DOID:1883	B19.2	D006526	609532		downregulated
tissue_expression_down	hsa-mir-372	Hepatitis C Virus Infection	16331254	disease by infectious agent	DOID:1883	B19.2	D006526	609532		downregulated
tissue_expression_down	hsa-mir-376c	Hepatitis C Virus Infection	16331254	disease by infectious agent	DOID:1883	B19.2	D006526	609532		downregulated
tissue_expression_down	hsa-mir-431	Hepatitis C Virus Infection	19360909	disease by infectious agent	DOID:1883	B19.2	D006526	609532		miR-431: down-regulated
tissue_expression_down	hsa-mir-448	Hepatitis C Virus Infection	19360909	disease by infectious agent	DOID:1883	B19.2	D006526	609532		miR-448: down-regulated
tissue_expression_down	hsa-let-7i	Hepatoblastoma	29404451	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	Let-7i-3p, miR-449b-3p, miR-624-5p, and miR-885-5p were decreased in tumors compared to normal livers
tissue_expression_down	hsa-mir-145	Hepatoblastoma	21145831	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	downregulated in early stages of HBV-associated multistep hepatocarcinogenesis.
tissue_expression_down	hsa-mir-148a	Hepatoblastoma	19701500	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	downregulated
tissue_expression_down	hsa-mir-199b	Hepatoblastoma	21145831	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	downregulated in early stages of HBV-associated multistep hepatocarcinogenesis.
tissue_expression_down	hsa-mir-34a	Hepatoblastoma	27046304	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	miR-34s were deregulated in tumor tissues compared with corresponding noncancerous tissue samples
tissue_expression_down	hsa-mir-34b	Hepatoblastoma	27046304	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	miR-34s were deregulated in tumor tissues compared with corresponding noncancerous tissue samples
tissue_expression_down	hsa-mir-34c	Hepatoblastoma	27046304	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	miR-34s were deregulated in tumor tissues compared with corresponding noncancerous tissue samples
tissue_expression_down	hsa-mir-449b	Hepatoblastoma	29404451	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	Let-7i-3p, miR-449b-3p, miR-624-5p, and miR-885-5p were decreased in tumors compared to normal livers
tissue_expression_down	hsa-mir-624	Hepatoblastoma	29404451	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	Let-7i-3p, miR-449b-3p, miR-624-5p, and miR-885-5p were decreased in tumors compared to normal livers
tissue_expression_down	hsa-mir-885	Hepatoblastoma	29404451	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	Let-7i-3p, miR-449b-3p, miR-624-5p, and miR-885-5p were decreased in tumors compared to normal livers
tissue_expression_down	hsa-mir-205	Hereditary Hemorrhagic Telangiectasia	23800974	genetic disease	DOID:1270	I78.0	D013683	PS187300		MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells.
tissue_expression_down	hsa-mir-195	Hirschsprung Disease	25007945	gastrointestinal system disease	DOID:10487	Q43.1	D006627	600156	HP:0002251	Aberrant expression of miR-195 may involved in the pathogenesis of HSCR by down-regulated the level of DIEXF.
tissue_expression_down	hsa-mir-206	Hirschsprung Disease	25792468	gastrointestinal system disease	DOID:10487	Q43.1	D006627	600156	HP:0002251	Down-regulation of miR-206 is associated with Hirschsprung disease and suppresses cell migration and proliferation in cell models.
tissue_expression_down	hsa-let-7i	Human Immunodeficiency Virus Infection	27145859			B20	D015658	609423		HIV-1 infection decreases the expression of let-7i in CD4(+) T cells by attenuating its promoter activity.
tissue_expression_down	hsa-mir-150	Human Immunodeficiency Virus Infection	26937033			B20	D015658	609423		the T-cell activation-associated miR-15b, miR-142-3p, miR-142-5p, and miR-150 expression was significantly downregulated
tissue_expression_down	hsa-mir-217	Human Immunodeficiency Virus Infection	22406815			B20	D015658	609423		MiR-217 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation by down-regulation of SIRT1.
tissue_expression_down	hsa-mir-146a	Human Papilloma Virus Infection	27818285			B97.7	D027383			Down-regulation of microRNA-146a is associated with high-risk human papillomavirus infection and epidermal growth factor receptor overexpression in penile squamous cell carcinoma.
tissue_expression_down	hsa-mir-146a	Huntington Disease	26165466	nervous system disease	DOID:12858	G10	D006816	143100		This increase in the expressions of PCNA, CHEK1 and  CCNA2 was found to be the result of decreased expressions of miR-432, miR-146a, and (miR-19a and miR-146a)
tissue_expression_down	hsa-mir-19a	Huntington Disease	26165466	nervous system disease	DOID:12858	G10	D006816	143100		This increase in the expressions of PCNA, CHEK1 and  CCNA2 was found to be the result of decreased expressions of miR-432, miR-146a, and (miR-19a and miR-146a)
tissue_expression_down	hsa-mir-135b	Hypertension	27176897	cardiovascular system disease	DOID:10763	I10	D006973	145500	HP:0000822	4 were upregulated (miR鈥?18a, miR鈥?27, miR鈥?18e and miR鈥?532) and 2 downregulated (miR鈥?8 and miR鈥?35b) in SPE placentas compared with controls.
tissue_expression_down	hsa-mir-98	Hypertension	27176897	cardiovascular system disease	DOID:10763	I10	D006973	145500	HP:0000822	4 were upregulated (miR鈥?18a, miR鈥?27, miR鈥?18e and miR鈥?532) and 2 downregulated (miR鈥?8 and miR鈥?35b) in SPE placentas compared with controls.
tissue_expression_down	hsa-mir-1-1	Hypertrophy	21418519				D006984			IGF-1 deficiency retards AAC-induced cardiac hypertrophic and contractile changes via alleviating downregulation of miR-1 and miR-133a in response to left ventricular pressure overload.
tissue_expression_down	hsa-mir-1-2	Hypertrophy	21418519				D006984			IGF-1 deficiency retards AAC-induced cardiac hypertrophic and contractile changes via alleviating downregulation of miR-1 and miR-133a in response to left ventricular pressure overload.
tissue_expression_down	hsa-mir-133a-1	Hypertrophy	21418519				D006984			IGF-1 deficiency retards AAC-induced cardiac hypertrophic and contractile changes via alleviating downregulation of miR-1 and miR-133a in response to left ventricular pressure overload.
tissue_expression_down	hsa-mir-133a-2	Hypertrophy	21418519				D006984			IGF-1 deficiency retards AAC-induced cardiac hypertrophic and contractile changes via alleviating downregulation of miR-1 and miR-133a in response to left ventricular pressure overload.
tissue_expression_down	hsa-mir-125	Infection [unspecific]	29391047				D007239			upregulated miR-21, miR-155, miR-150, and miR-221, as well as downregulated miR-143 and miR-125, all of them previously linked to other bacterial infections
tissue_expression_down	hsa-mir-129	Infection [unspecific]	29425228				D007239			Seven of the 26 miRNAs, miR-99b-5p, miR-129-3p, miR-188-5p, miR-363-3p, miR-1295a, miR-4443 and miR-6721-5p, showed significantly decreased expression in individuals with detectable oral shedding
tissue_expression_down	hsa-mir-1295a	Infection [unspecific]	29425228				D007239			Seven of the 26 miRNAs, miR-99b-5p, miR-129-3p, miR-188-5p, miR-363-3p, miR-1295a, miR-4443 and miR-6721-5p, showed significantly decreased expression in individuals with detectable oral shedding
tissue_expression_down	hsa-mir-143	Infection [unspecific]	29391047				D007239			upregulated miR-21, miR-155, miR-150, and miR-221, as well as downregulated miR-143 and miR-125, all of them previously linked to other bacterial infections
tissue_expression_down	hsa-mir-188	Infection [unspecific]	29425228				D007239			Seven of the 26 miRNAs, miR-99b-5p, miR-129-3p, miR-188-5p, miR-363-3p, miR-1295a, miR-4443 and miR-6721-5p, showed significantly decreased expression in individuals with detectable oral shedding
tissue_expression_down	hsa-mir-363	Infection [unspecific]	29425228				D007239			Seven of the 26 miRNAs, miR-99b-5p, miR-129-3p, miR-188-5p, miR-363-3p, miR-1295a, miR-4443 and miR-6721-5p, showed significantly decreased expression in individuals with detectable oral shedding
tissue_expression_down	hsa-mir-4443	Infection [unspecific]	29425228				D007239			Seven of the 26 miRNAs, miR-99b-5p, miR-129-3p, miR-188-5p, miR-363-3p, miR-1295a, miR-4443 and miR-6721-5p, showed significantly decreased expression in individuals with detectable oral shedding
tissue_expression_down	hsa-mir-6721	Infection [unspecific]	29425228				D007239			Seven of the 26 miRNAs, miR-99b-5p, miR-129-3p, miR-188-5p, miR-363-3p, miR-1295a, miR-4443 and miR-6721-5p, showed significantly decreased expression in individuals with detectable oral shedding
tissue_expression_down	hsa-mir-99b	Infection [unspecific]	29425228				D007239			Seven of the 26 miRNAs, miR-99b-5p, miR-129-3p, miR-188-5p, miR-363-3p, miR-1295a, miR-4443 and miR-6721-5p, showed significantly decreased expression in individuals with detectable oral shedding
tissue_expression_down	hsa-let-7i	Inflammation	23509825				D007249			This let-7i downregulation in dendritic cells constitutes a novel feature of the modulatory activity that helminth-derived antigens exert on their host.
tissue_expression_down	hsa-mir-1-1	Inflammation	20098732				D007249			Low density miR array demonstrated that TWEAK inhibits the expression of several miRs including muscle-specific miR-1-1, miR-1-2, miR-133a, miR-133b and miR-206.
tissue_expression_down	hsa-mir-1-2	Inflammation	20098732				D007249			Low density miR array demonstrated that TWEAK inhibits the expression of several miRs including muscle-specific miR-1-1, miR-1-2, miR-133a, miR-133b and miR-206.
tissue_expression_down	hsa-mir-125b	Inflammation	26319761				D007249			The lower expression of miR-155 and miR-125b in ORG calves indicated the potential for maternal organic trace minerals in regulating the PMNL inflammatory response at least via alterations in mRNA and miRNA expression.
tissue_expression_down	hsa-mir-133a	Inflammation	20098732				D007249			Low density miR array demonstrated that TWEAK inhibits the expression of several miRs including muscle-specific miR-1-1, miR-1-2, miR-133a, miR-133b and miR-206.
tissue_expression_down	hsa-mir-133b	Inflammation	20098732				D007249			Low density miR array demonstrated that TWEAK inhibits the expression of several miRs including muscle-specific miR-1-1, miR-1-2, miR-133a, miR-133b and miR-206.
tissue_expression_down	hsa-mir-155	Inflammation	22326887				D007249			Glucocorticoids inhibit lipopolysaccharide-mediated inflammatory response by downregulating microRNA-155
tissue_expression_down	hsa-mir-206	Inflammation	20098732				D007249			Low density miR array demonstrated that TWEAK inhibits the expression of several miRs including muscle-specific miR-1-1, miR-1-2, miR-133a, miR-133b and miR-206.
tissue_expression_down	hsa-mir-223	Inflammation	22937006				D007249			Here we reported that the expression of microRNA-223 (miR-223) was significantly decreased in murine macrophages during activation by lipopolysaccharide (LPS) or poly (I∶C) stimulation.
tissue_expression_down	hsa-mir-145	Inflammation	23980205				D007249			We demonstrate that miR-145, downregulated by IFN-I,targets histone deacetylase 11 to promote innate IL-10 expression in macrophages.Our findings suggest a new IFN-I-mediated negative feedback loop in the fine-tuning of innate IL-10 production that creates precise coordination of innate immune responses.
tissue_expression_down	hsa-mir-155	Inflammation	25295729				D007249			Differential expression of microRNAs in Francisella tularensis-infected human macrophages: miR-155-dependent downregulation of MyD88 inhibits the inflammatory  response.
tissue_expression_down	hsa-mir-10a	Inflammatory Bowel Diseases	25281418	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	Our data indicate that miR-10a is decreased in the inflamed mucosa of IBD and downregulates mucosal inflammatory response through inhibition of IL-12/IL-23p40 and NOD2 expression, and blockade of Th1/Th17 cell immune responses. Thus, miR-10a could play a role in the pathogenesis and progression of IBD.
tissue_expression_down	hsa-mir-200	Inflammatory Bowel Diseases	27113480	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	Our finding of down-regulation of the miR-200 family  and up-regulation of transcription repressors Snail and Slug supports the postulated role of EMT in the pathogenesis of fibrosis in IBD.
tissue_expression_down	hsa-mir-346	Inflammatory Bowel Diseases	25192497	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	These data suggest that during mucosal inflammation TNF-α induces miR-346, which downregulates epithelial VDR. Mucosal VDR reduction in turn compromises the integrity of the mucosal epithelial barrier, further driving mucosal inflammation and colitis development.
tissue_expression_down	hsa-mir-320a	Interstitial Cystitis	20008142	urinary system disease	DOID:13949	N30.10-.11	D018856			demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels
tissue_expression_down	hsa-mir-320b-1	Interstitial Cystitis	20008142	urinary system disease	DOID:13949	N30.10-.11	D018856			demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels
tissue_expression_down	hsa-mir-320b-2	Interstitial Cystitis	20008142	urinary system disease	DOID:13949	N30.10-.11	D018856			demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels
tissue_expression_down	hsa-mir-320c-1	Interstitial Cystitis	20008142	urinary system disease	DOID:13949	N30.10-.11	D018856			demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels
tissue_expression_down	hsa-mir-320c-2	Interstitial Cystitis	20008142	urinary system disease	DOID:13949	N30.10-.11	D018856			demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels
tissue_expression_down	hsa-mir-320d-1	Interstitial Cystitis	20008142	urinary system disease	DOID:13949	N30.10-.11	D018856			demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels
tissue_expression_down	hsa-mir-320d-2	Interstitial Cystitis	20008142	urinary system disease	DOID:13949	N30.10-.11	D018856			demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels
tissue_expression_down	hsa-mir-328	Interstitial Cystitis	20008142	urinary system disease	DOID:13949	N30.10-.11	D018856			demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels
tissue_expression_down	hsa-mir-449b	Interstitial Cystitis	20008142	urinary system disease	DOID:13949	N30.10-.11	D018856			demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels
tissue_expression_down	hsa-mir-500a	Interstitial Cystitis	20008142	urinary system disease	DOID:13949	N30.10-.11	D018856			demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels
tissue_expression_down	hsa-let-7e	Interstitial Lung Disease	22782705	respiratory system disease	DOID:3082	J84	D017563	614748	HP:0006530	downregulated
tissue_expression_down	hsa-mir-142	Interstitial Lung Disease	22782705	respiratory system disease	DOID:3082	J84	D017563	614748	HP:0006530	miR-142-5p: downregulated
tissue_expression_down	hsa-mir-19a	Interstitial Lung Disease	22782705	respiratory system disease	DOID:3082	J84	D017563	614748	HP:0006530	downregulated
tissue_expression_down	hsa-mir-27a	Intervertebral Disc Degeneration	24086481	musculoskeletal system disease	DOID:90	M51	D055959	603932	HP:0008419	This present study revealed that downregulated miR-27a might develop a novel intervention for IDD treatment through the prevention of apoptosis in Nucleus pulposus Cells.
tissue_expression_down	hsa-let-7f	Ischemia	28345812	cardiovascular system disease	DOID:326		D007511	601367		Reduced expression of let-7f activates TGF-β/ALK5 pathway and leads to impaired ischaemia-induced neovascularization after cigarette smoke exposure.
tissue_expression_down	hsa-mir-122	Ischemia-Reperfusion Injury	27569279				D015427			Downregulation of miR-122 attenuates hypoxia/reoxygenation (H/R)-induced myocardial cell apoptosis by upregulating GATA-4.
tissue_expression_down	hsa-mir-146a	Ischemia-Reperfusion Injury	23498784				D015427			Down-regulation of microRNA-146a in the early stage of liver ischemia-reperfusion injury.
tissue_expression_down	hsa-mir-214	Ischemia-Reperfusion Injury	27530948				D015427			the expression of miR-214 of IR group was lower than that of control group
tissue_expression_down	hsa-let-7g	Ischemic Heart Disease	26655604			I25.9/I24.9	D017202			MiR-let-7a, -7c and -7g were downregulated in the adult mouse heart early after coronary occlusion
tissue_expression_down	hsa-mir-34a	Ischemic Heart Disease	24123326			I25.9/I24.9	D017202			miR-34a was downregulated in heat shocked Sca-11 stem cells (HSSca-11 cells),heat shock induces exosomal transfer of HSF1 from Sca-1(+) cells, which directs ischemic cardiomyocytes toward a prosurvival phenotype by epigenetic repression of miR-34a.
tissue_expression_down	hsa-let-7a-1	Kaposi Sarcoma	19252139	disease of cellular proliferation	DOID:8632	C46	D012514			let-7a: down-regulated
tissue_expression_down	hsa-let-7a-2	Kaposi Sarcoma	19252139	disease of cellular proliferation	DOID:8632	C46	D012514			let-7a: down-regulated
tissue_expression_down	hsa-let-7a-3	Kaposi Sarcoma	19252139	disease of cellular proliferation	DOID:8632	C46	D012514			let-7a: down-regulated
tissue_expression_down	hsa-let-7b	Kaposi Sarcoma	19252139	disease of cellular proliferation	DOID:8632	C46	D012514			let-7b: down-regulated
tissue_expression_down	hsa-let-7c	Kaposi Sarcoma	19252139	disease of cellular proliferation	DOID:8632	C46	D012514			let-7c: down-regulated
tissue_expression_down	hsa-let-7d	Kaposi Sarcoma	19252139	disease of cellular proliferation	DOID:8632	C46	D012514			let-7d: down-regulated
tissue_expression_down	hsa-let-7e	Kaposi Sarcoma	19252139	disease of cellular proliferation	DOID:8632	C46	D012514			let-7e: down-regulated
tissue_expression_down	hsa-let-7f-1	Kaposi Sarcoma	19252139	disease of cellular proliferation	DOID:8632	C46	D012514			let-7f: down-regulated
tissue_expression_down	hsa-let-7f-2	Kaposi Sarcoma	19252139	disease of cellular proliferation	DOID:8632	C46	D012514			let-7f: down-regulated
tissue_expression_down	hsa-let-7g	Kaposi Sarcoma	19252139	disease of cellular proliferation	DOID:8632	C46	D012514			let-7g: down-regulated
tissue_expression_down	hsa-let-7i	Kaposi Sarcoma	19252139	disease of cellular proliferation	DOID:8632	C46	D012514			let-7i: down-regulated
tissue_expression_down	hsa-mir-221	Kaposi Sarcoma	19252139	disease of cellular proliferation	DOID:8632	C46	D012514			miR-221: down-regulated
tissue_expression_down	hsa-mir-221	Kaposi Sarcoma	21715310	disease of cellular proliferation	DOID:8632	C46	D012514			In the present study, we show that Kaposi sarcoma-associated herpesvirus (KSHV), the etiological agent of KS, induces global miRNA changes in lymphatic endothelial cells (LECs). Specifically, the miR-221/miR-222 cluster is down-regulated, whereas miR-31 is up-regulated.
tissue_expression_down	hsa-mir-222	Kaposi Sarcoma	19252139	disease of cellular proliferation	DOID:8632	C46	D012514			miR-222: down-regulated
tissue_expression_down	hsa-mir-222	Kaposi Sarcoma	21715310	disease of cellular proliferation	DOID:8632	C46	D012514			In the present study, we show that Kaposi sarcoma-associated herpesvirus (KSHV), the etiological agent of KS, induces global miRNA changes in lymphatic endothelial cells (LECs). Specifically, the miR-221/miR-222 cluster is down-regulated, whereas miR-31 is up-regulated.
tissue_expression_down	hsa-mir-98	Kaposi Sarcoma	19252139	disease of cellular proliferation	DOID:8632	C46	D012514			miR-98: down-regulated
tissue_expression_down	hsa-mir-155	Kawasaki Syndrome	25039241	immune system disease	DOID:13378	M30.3	D009080	611775		These results suggest that the decrease in FoxP3(+) Treg might be associated with decreased expression of miR-155, leading to aberrant SOCS1/STAT-5 signalling and overexpression of miR-31 in patients with acute KD.
tissue_expression_down	hsa-mir-142	Kideny Transplant Rejection	27323802			T86.11	D006084			miR-142-5p was significantly (p鈥?鈥?.01) underexpressed in patients with DSA.
tissue_expression_down	hsa-mir-133a	Kidney Diseases [unspecific]	25871823			N18.9	D007674			This is the first report to analyze the correlation between ET-1-induced miRNA 133a overexpression in proteinuria resulting in MRP2 downregulation, which is a contributing factor for renal cytotoxicity. The detection of the miRNA 133a in urine samples can be possibly used as a monitor for cytotoxicity.
tissue_expression_down	hsa-mir-93	Kidney Neoplasms	25183046	disease of cellular proliferation	DOID:263	C64	D007680			TGF-beta induced RBL2 expression through down-regulating miR-93 in renal cancer cells. The newly identified TGF-beta/miR-93/RBL2 signal pathway reveals a new mechanism of TGF-beta induced growth arrest in renal cancer.
tissue_expression_down	hsa-mir-10a	Laryngeal Neoplasms	26268753			C32.3	D007822			Down regulation of miR-10a may be a useful molecular marker for grading of LEPL and diagnosis of early laryngeal cancer.
tissue_expression_down	hsa-mir-1-1	Laryngeal Neoplasms	20806854			C32.3	D007822			downregulated by 5 multiple
tissue_expression_down	hsa-mir-1-2	Laryngeal Neoplasms	20806854			C32.3	D007822			downregulated by 5 multiple
tissue_expression_down	hsa-mir-125b-1	Laryngeal Neoplasms	22605671			C32.3	D007822			Downregulation
tissue_expression_down	hsa-mir-125b-2	Laryngeal Neoplasms	22605671			C32.3	D007822			Downregulation
tissue_expression_down	hsa-mir-133a-1	Laryngeal Neoplasms	20806854			C32.3	D007822			downregulated by 5 multiple
tissue_expression_down	hsa-mir-133a-2	Laryngeal Neoplasms	20806854			C32.3	D007822			downregulated by 5 multiple
tissue_expression_down	hsa-mir-144	Laryngeal Neoplasms	20806854			C32.3	D007822			downregulated by 5 multiple
tissue_expression_down	hsa-mir-145	Laryngeal Neoplasms	22605671			C32.3	D007822			Downregulation
tissue_expression_down	hsa-mir-206	Laryngeal Neoplasms	20806854			C32.3	D007822			downregulated by 5 multiple
tissue_expression_down	hsa-mir-375	Laryngeal Neoplasms	20806854			C32.3	D007822			downregulated by 5 multiple
tissue_expression_down	hsa-mir-378a	Laryngeal Neoplasms	20806854			C32.3	D007822			downregulated by 5 multiple
tissue_expression_down	hsa-mir-384	Laryngeal Neoplasms	20806854			C32.3	D007822			downregulated by 5 multiple
tissue_expression_down	hsa-mir-422a	Laryngeal Neoplasms	20806854			C32.3	D007822			downregulated by 5 multiple
tissue_expression_down	hsa-mir-486	Laryngeal Neoplasms	20806854			C32.3	D007822			miR-486-5p: downregulated by 5 multiple
tissue_expression_down	hsa-mir-487a	Laryngeal Neoplasms	20806854			C32.3	D007822			downregulated by 5 multiple
tissue_expression_down	hsa-mir-141	Learned Helplessness	21275079				D006380			mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain.
tissue_expression_down	hsa-mir-182	Learned Helplessness	21275079				D006380			mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain.
tissue_expression_down	hsa-mir-183	Learned Helplessness	21275079				D006380			mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain.
tissue_expression_down	hsa-mir-200a	Learned Helplessness	21275079				D006380			mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain.
tissue_expression_down	hsa-mir-200b	Learned Helplessness	21275079				D006380			mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain.
tissue_expression_down	hsa-mir-200c	Learned Helplessness	21275079				D006380			mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain.
tissue_expression_down	hsa-mir-429	Learned Helplessness	21275079				D006380			mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain.
tissue_expression_down	hsa-mir-96	Learned Helplessness	21275079				D006380			mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain.
tissue_expression_down	hsa-mir-29	Leiomyoma	27233758	disease of cellular proliferation	DOID:127	D25	D007889	150699		Members of the miRNA-29 family (29a, 29b, 29c) are all down-regulated  in leiomyoma
tissue_expression_down	hsa-mir-17	Leukemia	25140305			C95	D007938	613065	HP:0001909	The antileukemia activity of natural product HQ17(3) is possibly associated with downregulation of miR-17-92 cluster.
tissue_expression_down	hsa-mir-495	Leukemia	23132946			C95	D007938	613065	HP:0001909	MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia
tissue_expression_down	hsa-mir-92	Leukemia	25140305			C95	D007938	613065	HP:0001909	The antileukemia activity of natural product HQ17(3) is possibly associated with downregulation of miR-17-92 cluster.
tissue_expression_down	hsa-mir-22	Leukemia, Lymphoblastic	25430416	disease of cellular proliferation	DOID:1037	C91.0	D007945	613065		proliferation of this subset mainly depends on microRNA-22 overexpression, which induces phosphatase and tensin homolog (PTEN) down-regulation and phosphoinositide 3-kinase (PI3K)/AKT pathway activation. These results underline  the role of the PI3K/AKT pathway at the origin of this proliferative pool in patients with UM CLL and provide additional rationale for the use of PI3K inhibitors.
tissue_expression_down	hsa-mir-145	Leukemia, Lymphoblastic, Acute, T-Cell	24745613	disease of cellular proliferation	DOID:5602	C91.0		613065	HP:0006727	Prognostic impact of microRNA-145 down-regulation in adult T-cell leukemia/lymphoma.
tissue_expression_down	hsa-mir-125b-1	Leukemia, Lymphocytic, Chronic, B-Cell	22723551	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	The downregulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state.
tissue_expression_down	hsa-mir-125b-2	Leukemia, Lymphocytic, Chronic, B-Cell	22723551	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	The downregulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state.
tissue_expression_down	hsa-mir-15	Leukemia, Lymphocytic, Chronic, B-Cell	23974981	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia.
tissue_expression_down	hsa-mir-16	Leukemia, Lymphocytic, Chronic, B-Cell	23974981	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia.
tissue_expression_down	hsa-mir-16-1	Leukemia, Lymphocytic, Chronic, B-Cell	17351108	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	New Zealand black (NZB) mice (NZB) tissue sourcesof RNA showed a decrease in miR-16 in the spleen; however, theNZB kidney was not decreased in miR-16 expression compared withthe control strain expression. In addition, the NZB-derivedmalignant B-cell line, LNC, had an even greater decreased expressionof miR-16 compared with C57Bl6 spleen.
tissue_expression_down	hsa-mir-16-2	Leukemia, Lymphocytic, Chronic, B-Cell	17351108	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	New Zealand black (NZB) mice (NZB) tissue sourcesof RNA showed a decrease in miR-16 in the spleen; however, theNZB kidney was not decreased in miR-16 expression compared withthe control strain expression. In addition, the NZB-derivedmalignant B-cell line, LNC, had an even greater decreased expressionof miR-16 compared with C57Bl6 spleen.
tissue_expression_down	hsa-mir-223	Leukemia, Lymphocytic, Chronic, B-Cell	22321781	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	The down-regulation of microRNA-223 was associated with disease aggressiveness in CLL.
tissue_expression_down	hsa-mir-29c	Leukemia, Lymphocytic, Chronic, B-Cell	24138306	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	down-regulation of miR-29c is associated with higher tumor burden and significantly predicts short survival in Chinese patients with CLL
tissue_expression_down	hsa-mir-143	Leukemia, Lymphocytic, Chronic, B-Cell	27111859	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	miR-143 was downregulated and miR-155 was overexpressed in 13q-H.
tissue_expression_down	hsa-mir-15a	Leukemia, Lymphocytic, Chronic, B-Cell	19591824	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma.
tissue_expression_down	hsa-mir-15a	Leukemia, Lymphocytic, Chronic, B-Cell	23615967	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	Significant upregulation of miR-150, miR-29c, miR-143 and miR-223 and downregulation of miR-15a was found in mutated versus unmutated CLL, with miR-15a showing the highest fold difference.
tissue_expression_down	hsa-mir-16-1	Leukemia, Lymphocytic, Chronic, B-Cell	19591824	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma.
tissue_expression_down	hsa-let-7f	Leukemia, Myeloid, Acute	24067109	disease of cellular proliferation	DOID:9119	C92.0	D015470		HP:0004820	MicroRNA let-7f is down-regulated in patients with refractory acute myeloid leukemia and is involved in chemotherapy resistance of adriamycin-resistant leukemic cells.
tissue_expression_down	hsa-mir-155	Leukemia, Myeloid, Acute	26055960	disease of cellular proliferation	DOID:9119	C92.0	D015470		HP:0004820	Our results suggest that activating mutation of FLT3 in AML can lead,through the induction of JUN, to an increased expression of miR-155, which then causes down-regulation of SPI1 and CEBPB and consequently may causes block of myeloid differentiation.
tissue_expression_down	hsa-mir-27a	Leukemia, Myeloid, Acute	27396688	disease of cellular proliferation	DOID:9119	C92.0	D015470		HP:0004820	We observed decreased levels of miRNA-27a but of not miRNA-138  in SKM-1/AzaC cells compared with SKM-1 cells.
tissue_expression_down	hsa-mir-34c	Leukemia, Myeloid, Acute	27577964	disease of cellular proliferation	DOID:9119	C92.0	D015470		HP:0004820	Low miR-34c expression is associated with poor outcome in de novo acute myeloid leukemia.
tissue_expression_down	hsa-mir-155	Leukemia, Myeloid, Chronic	22511990	disease of cellular proliferation	DOID:8552	C92.1	D015464		HP:0005506	Downregulation of mir-31, mir-155, and mir-564 in chronic myeloid leukemia cells.
tissue_expression_down	hsa-mir-155	Leukemia, Myeloid, Chronic	25833191	disease of cellular proliferation	DOID:8552	C92.1	D015464		HP:0005506	Some onco-miRNAs were found to be downregulated (miR-155 and miR-106), and some tumor suppressor miRs (miR-16-1, miR-15a, miR-101, miR-568) were upregulated.
tissue_expression_down	hsa-mir-31	Leukemia, Myeloid, Chronic	22511990	disease of cellular proliferation	DOID:8552	C92.1	D015464		HP:0005506	Downregulation of mir-31, mir-155, and mir-564 in chronic myeloid leukemia cells.
tissue_expression_down	hsa-mir-370	Leukemia, Myeloid, Chronic	24148180	disease of cellular proliferation	DOID:8552	C92.1	D015464		HP:0005506	MiR-370 sensitized K562 cells to HHT by inducing apoptosis in part by downregulation of FoxM1 expression. These findings may provide further information for CML treatment with HHT.
tissue_expression_down	hsa-mir-564	Leukemia, Myeloid, Chronic	22511990	disease of cellular proliferation	DOID:8552	C92.1	D015464		HP:0005506	Downregulation of mir-31, mir-155, and mir-564 in chronic myeloid leukemia cells.
tissue_expression_down	hsa-mir-181a	Leukemia, Promyelocytic, Acute	22967415	disease of cellular proliferation	DOID:0060318	C92.4	D015473	612376	HP:0004836	The expression level of miR-15b, miR-16, miR-107, miR-223 and miR-342 in APL CR group were significantly upregulated compared with that of newly diagnosed APL groups (P < 0.05), while the expression level of miR-181a was significantly downregulated (P < 0.05).
tissue_expression_down	hsa-mir-17	Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic	19347736	disease of cellular proliferation	DOID:5599	C83.5	D054218			miR-17-5p: down-regulated
tissue_expression_down	hsa-mir-29a	Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic	19347736	disease of cellular proliferation	DOID:5599	C83.5	D054218			miR-29: down-regulated
tissue_expression_down	hsa-mir-29b-1	Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic	19347736	disease of cellular proliferation	DOID:5599	C83.5	D054218			miR-29: down-regulated
tissue_expression_down	hsa-mir-29b-2	Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic	19347736	disease of cellular proliferation	DOID:5599	C83.5	D054218			miR-29: down-regulated
tissue_expression_down	hsa-mir-29c	Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic	19347736	disease of cellular proliferation	DOID:5599	C83.5	D054218			miR-29: down-regulated
tissue_expression_down	hsa-mir-34a	Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic	19347736	disease of cellular proliferation	DOID:5599	C83.5	D054218			miR-34a: down-regulated
tissue_expression_down	hsa-mir-125b-1	Lichen Planus	21943223	integumentary system disease	DOID:9201	L43	D008010	151620		Increased expression of miR-21 and miR-203, decreased expression of miR-125, and down-regulation of p53 and deltaNp63 RNA were seen in OLP compared to normal oral mucosa. When comparing microRNA expression to levels of p53 and p63 RNA, a significant negative correlation was seen between deltaNp63 and miR-203 and between miR-21 and p53, respectively.
tissue_expression_down	hsa-mir-125b-2	Lichen Planus	21943223	integumentary system disease	DOID:9201	L43	D008010	151620		Increased expression of miR-21 and miR-203, decreased expression of miR-125, and down-regulation of p53 and deltaNp63 RNA were seen in OLP compared to normal oral mucosa. When comparing microRNA expression to levels of p53 and p63 RNA, a significant negative correlation was seen between deltaNp63 and miR-203 and between miR-21 and p53, respectively.
tissue_expression_down	hsa-mir-26b	Lichen Planus	22017396	integumentary system disease	DOID:9201	L43	D008010	151620		Levels of COX-2 mRNA were significantly higher while levels of miR-26b were significantly lower in OLP lesions compared to controls. Increased expression of COX-2 and decreased expression of miR-26b in OLP suggests both to play a role in OLP.
tissue_expression_down	hsa-mir-27b	Lichen Planus	22077423	integumentary system disease	DOID:9201	L43	D008010	151620		miR-27b was significantly down-regulated in OLP tissue, and miR-27b expression was even more suppressed in atrophic-erosive OLP than in reticular OLP. In addition, miR-27b was found to be expressed in the epithelial keratinocyte layer of both normal and OLP tissues.
tissue_expression_down	hsa-mir-122	Liver Cirrhosis	26167081	endocrine system disease	DOID:5082	K74	D008103	215600	HP:0001394	Reduced expression of miR-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies.
tissue_expression_down	hsa-mir-200b	Liver Cirrhosis	28634212	endocrine system disease	DOID:5082	K74	D008103	215600	HP:0001394	Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation.
tissue_expression_down	hsa-mir-15a	Liver Diseases [unspecific]	19360909			K76.9	D008107			miR-15a: decreased
tissue_expression_down	hsa-mir-34a	Liver Diseases [unspecific]	26567713			K76.9	D008107			These results suggested that AFB1 might down-regulate Wnt/β-catenin signaling pathway in HepG2 cells by up-regulating miR-34a, which may involve in the mechanism of liver tumorigenesis.
tissue_expression_down	hsa-mir-370	Liver Diseases [unspecific]	26608583			K76.9	D008107			up-regulated de novo lipogenesis (DNL) related proteins expression (ACC, SCD1), and down-regulated expressions of miR-122, miR-370 and miR-33;
tissue_expression_down	hsa-mir-22	Liver Neoplasms	26239725	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	microRNA-22 downregulation of galectin-9 influences lymphocyte apoptosis and tumor cell proliferation in liver cancer.
tissue_expression_down	hsa-mir-133b	Liver Neoplasms	19946373	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	downregulated
tissue_expression_down	hsa-mir-148b	Liver Neoplasms	21176238	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	mir-148b* is underexpressed in side population of HCC cells compared to fetal liver cells
tissue_expression_down	hsa-mir-200a	Liver Neoplasms	21176238	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	mir-200a* is underexpressed in side population of HCC cells compared to fetal liver cells
tissue_expression_down	hsa-mir-486	Liver Neoplasms	19946373	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	miR-486-5p: downregulated
tissue_expression_down	hsa-mir-21	Lung Fibrosis	25704671	respiratory system disease	DOID:3770	J84.10	D011658	178500		our results demonstrate that by decreasing IFN-γ-induced STAT3/p-STAT3 expression to down-regulate miR-21,sulindac could significantly reverse EMT in A549 cells and prevent BLM-induced PF.
tissue_expression_down	hsa-let-7a	Lung Neoplasms	28846189	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Let-7a, miR-16 and miR-34a, were found to be significantly downregulated by chronic PM2.5 exposure
tissue_expression_down	hsa-mir-1	Lung Neoplasms	19748927	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-21, mir-31, miR-130a, miR-146b and miR-377 were consistently upregulated, whereas miR-1 and miR-143 were downregulated in lung tumors relative to normal lungs.
tissue_expression_down	hsa-mir-100	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-101	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-101-1	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-107	Lung Neoplasms	25120851	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	The expression of miR-107 was decreased in NSCLC. Low expression of miR-107 was significantly associated with tumor progression and decreased survival in patients with NSCLC, indicating that miR-107 may serve as a novel prognostic marker in NSCLC.
tissue_expression_down	hsa-mir-107	Lung Neoplasms	26722426	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	c-Myc-activated long non-coding RNA H19 downregulates miR-107 and promotes cell cycle progression of non-small cell lung cancer.
tissue_expression_down	hsa-mir-1-1	Lung Neoplasms	23761296	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Sustainable downregulation in the lung tissues in lung carcinogenesis induced by urethane.
tissue_expression_down	hsa-mir-1-2	Lung Neoplasms	23761296	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Sustainable downregulation in the lung tissues in lung carcinogenesis induced by urethane.
tissue_expression_down	hsa-mir-1224	Lung Neoplasms	21563230	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. 
tissue_expression_down	hsa-mir-124	Lung Neoplasms	25973090	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Down-regulation of microRNA-124 is correlated with tumor metastasis and poor prognosis in patients with lung cancer.
tissue_expression_down	hsa-mir-124-1	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);
tissue_expression_down	hsa-mir-124-2	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);
tissue_expression_down	hsa-mir-124-3	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);
tissue_expression_down	hsa-mir-125a	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-125b	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-125b-1	Lung Neoplasms	25120851	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	The expression of miR-107 was decreased in NSCLC. Low expression of miR-107 was significantly associated with tumor progression and decreased survival in patients with NSCLC, indicating that miR-107 may serve as a novel prognostic marker in NSCLC.
tissue_expression_down	hsa-mir-126	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-126	Lung Neoplasms	22672859	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Four up-regulated microRNAs (miR-210, miR-21, miR-31 and miR-182) and two down-regulated mcroiRNAs (miR-126 and miR-145) were consistently reported both in squamous carcinoma and adenocarcinoma-based subgroup analysis
tissue_expression_down	hsa-mir-126	Lung Neoplasms	29516903	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs
tissue_expression_down	hsa-mir-126	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-130a	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-130b	Lung Neoplasms	25120851	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	The expression of miR-107 was decreased in NSCLC. Low expression of miR-107 was significantly associated with tumor progression and decreased survival in patients with NSCLC, indicating that miR-107 may serve as a novel prognostic marker in NSCLC.
tissue_expression_down	hsa-mir-133b	Lung Neoplasms	19946373	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulated
tissue_expression_down	hsa-mir-134	Lung Neoplasms	22306127	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-27b and miR-134 levels were significantly lower in the tumors than normal tissue.
tissue_expression_down	hsa-mir-140	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-142	Lung Neoplasms	19618089	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-34c, miR-145, or miR-142-5p expression markedly diminished proliferation of lung cancer cell lines, clinical implications discussed
tissue_expression_down	hsa-mir-143	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-143	Lung Neoplasms	20363096	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulated; Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis
tissue_expression_down	hsa-mir-143	Lung Neoplasms	19748927	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-21, mir-31, miR-130a, miR-146b and miR-377 were consistently upregulated, whereas miR-1 and miR-143 were downregulated in lung tumors relative to normal lungs.
tissue_expression_down	hsa-mir-143	Lung Neoplasms	29516903	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs
tissue_expression_down	hsa-mir-143	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-145	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-145	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-145 downregulated in breast cancer (Iorio et al., 2005) and lung cancer and deleted in prostate cancer (Yanaihara et al., 2006);
tissue_expression_down	hsa-mir-145	Lung Neoplasms	19618089	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-34c, miR-145, or miR-142-5p expression markedly diminished proliferation of lung cancer cell lines, clinical implications discussed
tissue_expression_down	hsa-mir-145	Lung Neoplasms	22672859	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Four up-regulated microRNAs (miR-210, miR-21, miR-31 and miR-182) and two down-regulated mcroiRNAs (miR-126 and miR-145) were consistently reported both in squamous carcinoma and adenocarcinoma-based subgroup analysis
tissue_expression_down	hsa-mir-145	Lung Neoplasms	26309531	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	We have found that miR-145 is dramatically down-regulated in clinical specimen of lung cancer
tissue_expression_down	hsa-mir-145	Lung Neoplasms	29516903	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs
tissue_expression_down	hsa-mir-145	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-155	Lung Neoplasms	19597153	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	down-regulated miR
tissue_expression_down	hsa-mir-16	Lung Neoplasms	28846189	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Let-7a, miR-16 and miR-34a, were found to be significantly downregulated by chronic PM2.5 exposure
tissue_expression_down	hsa-mir-181a	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-181a-2	Lung Neoplasms	20363096	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulated; Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis
tissue_expression_down	hsa-mir-181c	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-181c	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-181c-prec downregulated in lung cancer (Yanaihara et al., 2006);
tissue_expression_down	hsa-mir-186	Lung Neoplasms	23204228	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-186 Downregulation Correlates with Poor Survival in Lung Adenocarcinoma,Where It Interferes with Cell-Cycle Regulation
tissue_expression_down	hsa-mir-18b	Lung Neoplasms	19618089	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-34c, miR-145, or miR-142-5p expression markedly diminished proliferation of lung cancer cell lines, clinical implications discussed
tissue_expression_down	hsa-mir-192	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-192-prec downregulation
tissue_expression_down	hsa-mir-193a	Lung Neoplasms	22325218	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-33a was down-regulated by 92.8% and mir-193a-3p by 86.5% in epithelial-mesenchymal transition (EMT) on the expression of microRNAs (miRNAs) in lung cancer A549 cells.
tissue_expression_down	hsa-mir-198	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-199a	Lung Neoplasms	24022342	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation of miR-199a is essential for hypoxia-induced proliferation through derepressing the expression of HIF1a expression and affecting HIF1a mediated glycolytic pathway in NSCLC progression.
tissue_expression_down	hsa-mir-199b	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-202	Lung Neoplasms	21563230	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. 
tissue_expression_down	hsa-mir-216a	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-216b	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-218-2	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-218-2	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-218-2 downregulated in lung cancer (Yanaihara et al., 2006)
tissue_expression_down	hsa-mir-219-1	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-223	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);
tissue_expression_down	hsa-mir-224	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-25	Lung Neoplasms	25432132	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	CDC42 was confirmed to be the directly regulated by miR-25 in A549 cells. Upregulation of CDC42 in A549 cells rescued the inhibitory effect on proliferation and the G1 cell cycle arrest induced by miR-25 downregulation. Our  study demonstrates miR-25, by targeting CDC42, is an important regulator in NSCLC.
tissue_expression_down	hsa-mir-26a	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-26a-1	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-26a-1	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-26a-1-prec downregulated in lung cancer, deleted in epithelial cancers (Yanaihara et al., 2006)
tissue_expression_down	hsa-mir-26b	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-27b	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-27b	Lung Neoplasms	22306127	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-27b and miR-134 levels were significantly lower in the tumors than normal tissue.
tissue_expression_down	hsa-mir-29a	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);
tissue_expression_down	hsa-mir-29a	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-29b-1	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-29b-1	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);
tissue_expression_down	hsa-mir-29b-2	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);
tissue_expression_down	hsa-mir-29c	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);
tissue_expression_down	hsa-mir-29c	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-30a	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-30a	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006);
tissue_expression_down	hsa-mir-30a	Lung Neoplasms	27374108	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-30a-3p and miR-30a-5p were significantly decreased in tumors
tissue_expression_down	hsa-mir-30a	Lung Neoplasms	29516903	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs
tissue_expression_down	hsa-mir-30a	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-30b	Lung Neoplasms	25249344	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	We demonstrated that miR-30b/c was down-regulated in NSCLC specimens compared with adjacent non-tumor tissues. miR-30b/c directly targeted and down-regulated Rab18 expression and inhibited NSCLC cells proliferation. These data indicated that miR-30b/c could serve as a tumor suppressor gene involved in NSCLC pathogenesis.
tissue_expression_down	hsa-mir-30b	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)
tissue_expression_down	hsa-mir-30b	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-30c	Lung Neoplasms	25119247	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Low expression of microRNA-30c promotes invasion by inducing epithelial mesenchymal transition in non-small cell lung cancer.
tissue_expression_down	hsa-mir-30c	Lung Neoplasms	25249344	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	We demonstrated that miR-30b/c was down-regulated in NSCLC specimens compared with adjacent non-tumor tissues. miR-30b/c directly targeted and down-regulated Rab18 expression and inhibited NSCLC cells proliferation. These data indicated that miR-30b/c could serve as a tumor suppressor gene involved in NSCLC pathogenesis.
tissue_expression_down	hsa-mir-30c-1	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)
tissue_expression_down	hsa-mir-30c-2	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)
tissue_expression_down	hsa-mir-30d	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)
tissue_expression_down	hsa-mir-30d	Lung Neoplasms	29516903	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs
tissue_expression_down	hsa-mir-30d	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-30e	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)
tissue_expression_down	hsa-mir-30e	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-32	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-32	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-32 downregulated in lung cancer (Yanaihara et al., 2006);
tissue_expression_down	hsa-mir-320	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-33a	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-33a	Lung Neoplasms	22325218	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-33a was down-regulated by 92.8% and mir-193a-3p by 86.5% in epithelial-mesenchymal transition (EMT) on the expression of microRNAs (miRNAs) in lung cancer A549 cells.
tissue_expression_down	hsa-mir-33b	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-34a	Lung Neoplasms	25501507	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-34a could inhibit the proliferation and promote the apoptosis of H1299 cells partially through the downregulation of its target gene TGFβR2.
tissue_expression_down	hsa-mir-34a	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)
tissue_expression_down	hsa-mir-34a	Lung Neoplasms	28846189	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Let-7a, miR-16 and miR-34a, were found to be significantly downregulated by chronic PM2.5 exposure
tissue_expression_down	hsa-mir-34b	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)
tissue_expression_down	hsa-mir-34b	Lung Neoplasms	21339737	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	A microRNA, miR-34b, that suppresses the expression of alpha4 through specific binding to the 3'-untranslated region of alpha4 is downregulated in transformed or human lung tumors.
tissue_expression_down	hsa-mir-34c	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)
tissue_expression_down	hsa-mir-34c	Lung Neoplasms	23805317	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	MiR-34a and miR-34c were downregulated in lung tumors compared to normal tissues.
tissue_expression_down	hsa-mir-451	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-451a	Lung Neoplasms	29516903	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs
tissue_expression_down	hsa-mir-486	Lung Neoplasms	19946373	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-486-5p: downregulated
tissue_expression_down	hsa-mir-486	Lung Neoplasms	29516903	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs
tissue_expression_down	hsa-mir-605	Lung Neoplasms	21563230	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. 
tissue_expression_down	hsa-mir-652	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-663	Lung Neoplasms	25301444	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Waltonitone induces apoptosis through mir-663-induced Bcl-2 downregulation in non-small cell lung cancer.
tissue_expression_down	hsa-mir-671	Lung Neoplasms	21563230	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. 
tissue_expression_down	hsa-mir-886	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-9-1	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-9-2	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-9-3	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-939	Lung Neoplasms	21563230	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. 
tissue_expression_down	hsa-mir-95	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	downregulation
tissue_expression_down	hsa-mir-99a	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_down	hsa-mir-101-1	Lymphoma	21960592	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	The down-regulation of miR-16, miR-26a, miR-101, miR-29c and miR138 in the t(14;18)-negative FL( follicular lymphoma ) subset was associated with profound mRNA expression changes of potential target genes involving cell cycle control, apoptosis and B-cell differentiation. miR-16 target CHEK1 showed increased expression on the protein level in t(14;18)-negative FL, while TCL1A expression was reduced, in line with a partial loss of the germinal center B-cell phenotype in this FL subset.
tissue_expression_down	hsa-mir-101-2	Lymphoma	21960592	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	The down-regulation of miR-16, miR-26a, miR-101, miR-29c and miR138 in the t(14;18)-negative FL( follicular lymphoma ) subset was associated with profound mRNA expression changes of potential target genes involving cell cycle control, apoptosis and B-cell differentiation. miR-16 target CHEK1 showed increased expression on the protein level in t(14;18)-negative FL, while TCL1A expression was reduced, in line with a partial loss of the germinal center B-cell phenotype in this FL subset.
tissue_expression_down	hsa-mir-125a	Lymphoma	22307176	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	significantly underexpressed in SMZL (splenic marginal zone lymphoma).
tissue_expression_down	hsa-mir-126	Lymphoma	22307176	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	significantly underexpressed in SMZL (splenic marginal zone lymphoma).
tissue_expression_down	hsa-mir-133b	Lymphoma	19946373	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	downregulated
tissue_expression_down	hsa-mir-138-1	Lymphoma	21960592	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	The down-regulation of miR-16, miR-26a, miR-101, miR-29c and miR138 in the t(14;18)-negative FL( follicular lymphoma ) subset was associated with profound mRNA expression changes of potential target genes involving cell cycle control, apoptosis and B-cell differentiation. miR-16 target CHEK1 showed increased expression on the protein level in t(14;18)-negative FL, while TCL1A expression was reduced, in line with a partial loss of the germinal center B-cell phenotype in this FL subset.
tissue_expression_down	hsa-mir-138-2	Lymphoma	21960592	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	The down-regulation of miR-16, miR-26a, miR-101, miR-29c and miR138 in the t(14;18)-negative FL( follicular lymphoma ) subset was associated with profound mRNA expression changes of potential target genes involving cell cycle control, apoptosis and B-cell differentiation. miR-16 target CHEK1 showed increased expression on the protein level in t(14;18)-negative FL, while TCL1A expression was reduced, in line with a partial loss of the germinal center B-cell phenotype in this FL subset.
tissue_expression_down	hsa-mir-139	Lymphoma	22307176	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	significantly underexpressed in SMZL (splenic marginal zone lymphoma).
tissue_expression_down	hsa-mir-146a	Lymphoma	22307176	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	significantly overexpressed in SMZL (splenic marginal zone lymphoma).
tissue_expression_down	hsa-mir-155	Lymphoma	22307176	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	significantly overexpressed in SMZL (splenic marginal zone lymphoma).
tissue_expression_down	hsa-mir-15a	Lymphoma	21118128	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	Both decreased expression of miR-15a and miR-16-1 and increased nucleolin have been shown to be associated with increased Bcl2 expression and resistance to apoptosis in the common human disease, chronic lymphocytic leukaemia.
tissue_expression_down	hsa-mir-16-1	Lymphoma	21778999	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas.
tissue_expression_down	hsa-mir-16-1	Lymphoma	21960592	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	The down-regulation of miR-16, miR-26a, miR-101, miR-29c and miR138 in the t(14;18)-negative FL( follicular lymphoma ) subset was associated with profound mRNA expression changes of potential target genes involving cell cycle control, apoptosis and B-cell differentiation. miR-16 target CHEK1 showed increased expression on the protein level in t(14;18)-negative FL, while TCL1A expression was reduced, in line with a partial loss of the germinal center B-cell phenotype in this FL subset.
tissue_expression_down	hsa-mir-16-1	Lymphoma	21118128	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	Both decreased expression of miR-15a and miR-16-1 and increased nucleolin have been shown to be associated with increased Bcl2 expression and resistance to apoptosis in the common human disease, chronic lymphocytic leukaemia.
tissue_expression_down	hsa-mir-16-2	Lymphoma	21778999	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas.
tissue_expression_down	hsa-mir-16-2	Lymphoma	21960592	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	The down-regulation of miR-16, miR-26a, miR-101, miR-29c and miR138 in the t(14;18)-negative FL( follicular lymphoma ) subset was associated with profound mRNA expression changes of potential target genes involving cell cycle control, apoptosis and B-cell differentiation. miR-16 target CHEK1 showed increased expression on the protein level in t(14;18)-negative FL, while TCL1A expression was reduced, in line with a partial loss of the germinal center B-cell phenotype in this FL subset.
tissue_expression_down	hsa-mir-21	Lymphoma	22307176	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	significantly overexpressed in SMZL (splenic marginal zone lymphoma).
tissue_expression_down	hsa-mir-29c	Lymphoma	21960592	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	The down-regulation of miR-16, miR-26a, miR-101, miR-29c and miR138 in the t(14;18)-negative FL( follicular lymphoma ) subset was associated with profound mRNA expression changes of potential target genes involving cell cycle control, apoptosis and B-cell differentiation. miR-16 target CHEK1 showed increased expression on the protein level in t(14;18)-negative FL, while TCL1A expression was reduced, in line with a partial loss of the germinal center B-cell phenotype in this FL subset.
tissue_expression_down	hsa-mir-345	Lymphoma	22307176	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	significantly underexpressed in SMZL (splenic marginal zone lymphoma).
tissue_expression_down	hsa-mir-486	Lymphoma	19946373	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	miR-486-5p: downregulated
tissue_expression_down	hsa-mir-499a	Lymphoma	19690137	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	deregulated, hypermutations
tissue_expression_down	hsa-mir-377	Lymphoma, B-Cell	26537004	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	These findings reveal a novel mechanism by which down-regulation of miR-377 increases BCL-xL expression, promoting chemotherapy resistance in B-cell lymphoid malignancies.
tissue_expression_down	hsa-let-7c	Lymphoma, Burkitt	18802929	disease of cellular proliferation	DOID:8584	C83.7	D002051	113970	HP:0030080	In particular, down-regulation of hsa-let-7c was observed in BL cases, compared to normal controls.
tissue_expression_down	hsa-mir-17	Lymphoma, Large B-Cell, Diffuse	28817403	disease of cellular proliferation	DOID:0050745	C83.3	D016403	109565		PB-DLBCL and DLBCL-GCB-CC also had much higher levels of miR-125a-3p, miR-34-3p, and miR-155-5p, and significantly lower levels of miR-17-5p and miR-17-3p
tissue_expression_down	hsa-mir-221	Lymphoma, Large B-Cell, Diffuse	26683099	disease of cellular proliferation	DOID:0050745	C83.3	D016403	109565		Among antiangiomiRs we found decreased expression of miR-16, miR-20b, miR-92a, miR-221 and miR-328
tissue_expression_down	hsa-mir-26b	Lymphoma, Non-Hodgkin	24651473	disease of cellular proliferation	DOID:0060060	C85.9	D008228	605027	HP:0012539	We propose that activation of both canonical and alternative NF-κB signalling pathways and down-regulation of miR-26b contribute to the development  of HCV-associated B-NHL.
tissue_expression_down	hsa-let-7a-1	Lymphoma, Primary Effusion	19252139			C83.8	D054685			let-7a: down-regulated
tissue_expression_down	hsa-let-7a-2	Lymphoma, Primary Effusion	19252139			C83.8	D054685			let-7a: down-regulated
tissue_expression_down	hsa-let-7a-3	Lymphoma, Primary Effusion	19252139			C83.8	D054685			let-7a: down-regulated
tissue_expression_down	hsa-let-7b	Lymphoma, Primary Effusion	19252139			C83.8	D054685			let-7b: down-regulated
tissue_expression_down	hsa-let-7c	Lymphoma, Primary Effusion	19252139			C83.8	D054685			let-7c: down-regulated
tissue_expression_down	hsa-let-7d	Lymphoma, Primary Effusion	19252139			C83.8	D054685			let-7d: down-regulated
tissue_expression_down	hsa-let-7e	Lymphoma, Primary Effusion	19252139			C83.8	D054685			let-7e: down-regulated
tissue_expression_down	hsa-let-7f-1	Lymphoma, Primary Effusion	19252139			C83.8	D054685			let-7f: down-regulated
tissue_expression_down	hsa-let-7f-2	Lymphoma, Primary Effusion	19252139			C83.8	D054685			let-7f: down-regulated
tissue_expression_down	hsa-let-7g	Lymphoma, Primary Effusion	19252139			C83.8	D054685			let-7g: down-regulated
tissue_expression_down	hsa-let-7i	Lymphoma, Primary Effusion	19252139			C83.8	D054685			let-7i: down-regulated
tissue_expression_down	hsa-mir-221	Lymphoma, Primary Effusion	19252139			C83.8	D054685			miR-221: down-regulated
tissue_expression_down	hsa-mir-222	Lymphoma, Primary Effusion	19252139			C83.8	D054685			miR-222: down-regulated
tissue_expression_down	hsa-mir-98	Lymphoma, Primary Effusion	19252139			C83.8	D054685			miR-98: down-regulated
tissue_expression_down	hsa-mir-101-1	Lymphoma, T-Cell	21921041	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	Re-expression of downregulated miRNAs, such as mir-101, mir-26a, mir26b, mir-28-5 and mir-363, reduced the growth of NK cell line and modulated the expression of their predicted target genes.
tissue_expression_down	hsa-mir-101-2	Lymphoma, T-Cell	21921041	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	Re-expression of downregulated miRNAs, such as mir-101, mir-26a, mir26b, mir-28-5 and mir-363, reduced the growth of NK cell line and modulated the expression of their predicted target genes.
tissue_expression_down	hsa-mir-17	Lymphoma, T-Cell	20448109	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	mir-17:down-regulation of the miR-17-92 cluster in malignancy
tissue_expression_down	hsa-mir-18a	Lymphoma, T-Cell	20448109	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	mir-18a:down-regulation of the miR-17-92 cluster in malignancy
tissue_expression_down	hsa-mir-19a	Lymphoma, T-Cell	20448109	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	mir-19a:down-regulation of the miR-17-92 cluster in malignancy
tissue_expression_down	hsa-mir-19b-1	Lymphoma, T-Cell	20448109	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	mir-19b:down-regulation of the miR-17-92 cluster in malignancy
tissue_expression_down	hsa-mir-19b-2	Lymphoma, T-Cell	20448109	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	mir-19b:down-regulation of the miR-17-92 cluster in malignancy
tissue_expression_down	hsa-mir-20a	Lymphoma, T-Cell	20448109	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	mir-20a:down-regulation of the miR-17-92 cluster in malignancy
tissue_expression_down	hsa-mir-26a-1	Lymphoma, T-Cell	21921041	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	Re-expression of downregulated miRNAs, such as mir-101, mir-26a, mir26b, mir-28-5 and mir-363, reduced the growth of NK cell line and modulated the expression of their predicted target genes.
tissue_expression_down	hsa-mir-26a-2	Lymphoma, T-Cell	21921041	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	Re-expression of downregulated miRNAs, such as mir-101, mir-26a, mir26b, mir-28-5 and mir-363, reduced the growth of NK cell line and modulated the expression of their predicted target genes.
tissue_expression_down	hsa-mir-26b	Lymphoma, T-Cell	21921041	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	Re-expression of downregulated miRNAs, such as mir-101, mir-26a, mir26b, mir-28-5 and mir-363, reduced the growth of NK cell line and modulated the expression of their predicted target genes.
tissue_expression_down	hsa-mir-92a-1	Lymphoma, T-Cell	20448109	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	mir-92a:down-regulation of the miR-17-92 cluster in malignancy
tissue_expression_down	hsa-mir-92a-2	Lymphoma, T-Cell	20448109	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	mir-92a:down-regulation of the miR-17-92 cluster in malignancy
tissue_expression_down	hsa-mir-200c	Malignant Neoplasms [unspecific]	25766530			C80.1	D009369			This systematic review and meta-analysis clarified that low expression of miR-200c in primary tissue was significantly associated with poor survival in cancer patients at early stage, whereas a high level of blood miR-200c predicted poor prognosis in patients with advanced tumors.
tissue_expression_down	hsa-mir-106a	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-106a* was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_down	hsa-mir-10a	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-10a was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_down	hsa-mir-181c	Medulloblastoma	29658967	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma
tissue_expression_down	hsa-mir-181d	Medulloblastoma	29658967	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma
tissue_expression_down	hsa-mir-218	Medulloblastoma	23970061	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	miR-218 is downregulated and directly targets SH3GL1 in childhood medulloblastoma.
tissue_expression_down	hsa-mir-219-1	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-219-1-3p was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_down	hsa-mir-219	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-219-5p was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_down	hsa-mir-221	Medulloblastoma	29658967	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma
tissue_expression_down	hsa-mir-302b	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-302b* was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_down	hsa-mir-302d	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-302d* was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_down	hsa-mir-31	Medulloblastoma	18973228	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	miR-31: downregulated in all MBs
tissue_expression_down	hsa-mir-373	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-373 was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_down	hsa-mir-383	Medulloblastoma	23157748	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	Compared with normal brain tissue, decreased expression of miR-383 but elevated expression of PRDX3 are medulloblastoma tumour and Daoy cell lines
tissue_expression_down	hsa-mir-483	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-483-5p was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_down	hsa-mir-504	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-504 was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_down	hsa-mir-9	Medulloblastoma	29658967	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma
tissue_expression_down	hsa-mir-92b	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-92b* was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_down	hsa-mir-935	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-935 was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_down	hsa-mir-122	Melanoma	19578755	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	down-regulated
tissue_expression_down	hsa-mir-125b	Melanoma	20827223	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Downregulation of miR-125b in metastatic cutaneous malignant melanoma.
tissue_expression_down	hsa-mir-125b	Melanoma	24462553	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MicroRNA-125b is down-regulated and the target genes (ERBB3a and ERBB3b) are upregulated in fish melanomas
tissue_expression_down	hsa-mir-125b	Melanoma	27469124	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Benign Spitz lesions were characterized by decreased expression of miR-125b and miR-211, and upregulation of miR-22, compared with benign nevi (p < 0.05).
tissue_expression_down	hsa-mir-125b-1	Melanoma	21460750	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	the expression of miRNA-125b (miR-125b) was two-fold lower in malignant melanoma producing lymph node micrometastases than in nonmetastasizing tumors. MicroRNA miR-125b induces senescence in human melanoma cells.We propose that downregulation of miR-125b in an early cutaneous malignant melanoma can contribute to the increased metastatic capability of this tumor.
tissue_expression_down	hsa-mir-125b-2	Melanoma	21460750	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	the expression of miRNA-125b (miR-125b) was two-fold lower in malignant melanoma producing lymph node micrometastases than in nonmetastasizing tumors. MicroRNA miR-125b induces senescence in human melanoma cells.We propose that downregulation of miR-125b in an early cutaneous malignant melanoma can contribute to the increased metastatic capability of this tumor.
tissue_expression_down	hsa-mir-1308	Melanoma	22898827	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes.
tissue_expression_down	hsa-mir-134	Melanoma	26485753	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Altogether, our results suggest that HIFU down-regulates miR-134 to release the inhibition of miR-134 on CD86 in melanoma cells, thereby enhancing anti-tumor immune response.
tissue_expression_down	hsa-mir-137	Melanoma	24001901	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-34a, miR-137 and miR-182 all had lower expression levels in uveal melanoma cell lines, compared with normal cells
tissue_expression_down	hsa-mir-138-1	Melanoma	22551973	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors.
tissue_expression_down	hsa-mir-138-2	Melanoma	22551973	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors.
tissue_expression_down	hsa-mir-145	Melanoma	21509659	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	significantly down-regulated in uveal melanomas compared with normal uveal tissues
tissue_expression_down	hsa-mir-145	Melanoma	21836381	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MiR-145 was significantly down-regulated in canine malignant melanoma tissues. The ectopic expression of miR-145 showed a significant growth inhibition in both canine and human melanoma cells tested, and the effect was achieved partly by suppressing c-MYC in canine melanoma LMeC, and human melanoma A2058 and Mewo cells.
tissue_expression_down	hsa-mir-146a	Melanoma	27149382	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Among the miRNAs that were commonly and significantly down-regulated in each of these women were miR-193b (P<0.003), miR-342-3p (P<0.003), miR186 (P<0.007), miR-130a (P<0.007), and miR-146a (P<0.007).
tissue_expression_down	hsa-mir-146b	Melanoma	19578755	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	down-regulated
tissue_expression_down	hsa-mir-155	Melanoma	19578755	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	down-regulated
tissue_expression_down	hsa-mir-155	Melanoma	21763111	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Early steps in skin tumor formation in HPV8-CER mice were associated with an upregulation of the oncogenic miRNA-17-5p, -21 and -106a and a downregulation of the tumor-suppressive miRNA-155 and -206, which could be demonstrated by qPCR and in situ hybridization.
tissue_expression_down	hsa-mir-15a	Melanoma	22551973	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors.
tissue_expression_down	hsa-mir-16-1	Melanoma	22551973	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors.
tissue_expression_down	hsa-mir-16-2	Melanoma	22551973	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors.
tissue_expression_down	hsa-mir-181a-1	Melanoma	22551973	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors.
tissue_expression_down	hsa-mir-181a-2	Melanoma	22551973	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors.
tissue_expression_down	hsa-mir-182	Melanoma	24001901	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-34a, miR-137 and miR-182 all had lower expression levels in uveal melanoma cell lines, compared with normal cells
tissue_expression_down	hsa-mir-191	Melanoma	20357817	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Furthermore, low expression of miR-191 and high expression of miR-193b were associated with poor melanoma-specific survive
tissue_expression_down	hsa-mir-191	Melanoma	22551973	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors.
tissue_expression_down	hsa-mir-191	Melanoma	26156293	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In particular, miR-101, miR-221,miR-21, miR-338-3p and miR-191 resulted in significant downregulation inBRAF-mutated patients.
tissue_expression_down	hsa-mir-193a	Melanoma	20357817	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In melanomas, miR-193a, miR-338, and miR-565 were underexpressed in cases with a BRAF mutation.
tissue_expression_down	hsa-mir-193b	Melanoma	27149382	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Among the miRNAs that were commonly and significantly down-regulated in each of these women were miR-193b (P<0.003), miR-342-3p (P<0.003), miR186 (P<0.007), miR-130a (P<0.007), and miR-146a (P<0.007).
tissue_expression_down	hsa-mir-195	Melanoma	22847610	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-195-mediated downregulation of WEE1 in metastatic lesions may help to overcome cell cycle arrest under stress conditions in the local tissue microenvironment to allow unrestricted growth of tumour cells.
tissue_expression_down	hsa-mir-200c	Melanoma	20442294	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miRNA-200c:miRNA-200c to be consistently downregulated in melanocytes, melanoma cell lines, and patient samples, whereas miRNA-205 and miRNA-23b were markedly reduced only in patient samples
tissue_expression_down	hsa-mir-200c	Melanoma	22223089	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors.
tissue_expression_down	hsa-mir-203	Melanoma	22235882	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	A decreased expression of miR-203 was significantly associated with a shorter survival time. Also, miR-203 and -205 were markedly down-regulated in canine and human MM cell lines tested.
tissue_expression_down	hsa-mir-204	Melanoma	21509659	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	significantly down-regulated in uveal melanomas compared with normal uveal tissues
tissue_expression_down	hsa-mir-205	Melanoma	20442294	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miRNA-205:miRNA-200c to be consistently downregulated in melanocytes, melanoma cell lines, and patient samples, whereas miRNA-205 and miRNA-23b were markedly reduced only in patient samples
tissue_expression_down	hsa-mir-205	Melanoma	22223089	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors.
tissue_expression_down	hsa-mir-205	Melanoma	22235882	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	A decreased expression of miR-203 was significantly associated with a shorter survival time. Also, miR-203 and -205 were markedly down-regulated in canine and human MM cell lines tested.
tissue_expression_down	hsa-mir-205	Melanoma	23629002	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	microRNA (miR)-205 is downregulated and acts as a tumor suppressor in human melanoma cells.
tissue_expression_down	hsa-mir-206	Melanoma	21763111	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Early steps in skin tumor formation in HPV8-CER mice were associated with an upregulation of the oncogenic miRNA-17-5p, -21 and -106a and a downregulation of the tumor-suppressive miRNA-155 and -206, which could be demonstrated by qPCR and in situ hybridization.
tissue_expression_down	hsa-mir-211	Melanoma	21687938	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Downregulation of microRNA-211 is involved in expression of preferentially expressed antigen of melanoma in melanoma cells.
tissue_expression_down	hsa-mir-211	Melanoma	22223089	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors.
tissue_expression_down	hsa-mir-23b	Melanoma	20442294	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miRNA-23b:miRNA-200c to be consistently downregulated in melanocytes, melanoma cell lines, and patient samples, whereas miRNA-205 and miRNA-23b were markedly reduced only in patient samples
tissue_expression_down	hsa-mir-24-1	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_down	hsa-mir-26a	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_down	hsa-mir-26a-1	Melanoma	23190898	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MicroRNA-26a Is Strongly Downregulated in Melanoma and Induces Cell Death through Repression of Silencer of Death Domains
tissue_expression_down	hsa-mir-26a-2	Melanoma	23190898	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MicroRNA-26a Is Strongly Downregulated in Melanoma and Induces Cell Death through Repression of Silencer of Death Domains
tissue_expression_down	hsa-mir-338	Melanoma	20357817	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In melanomas, miR-193a, miR-338, and miR-565 were underexpressed in cases with a BRAF mutation.
tissue_expression_down	hsa-mir-34a	Melanoma	19830692	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-34a:MiR-15b and miR-210 were significantly upregulated, miR-34a was significantly downregulated in melanomas
tissue_expression_down	hsa-mir-34a	Melanoma	20606648	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-34a delivered by the GC4-targeted nanoparticles significantly downregulated the survivin expression in the metastatic tumor and reduced tumor load in the lung.
tissue_expression_down	hsa-mir-4291	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_down	hsa-mir-4317	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_down	hsa-mir-4324	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_down	hsa-mir-720	Melanoma	22898827	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes.
tissue_expression_down	hsa-mir-933	Melanoma	22551973	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors.
tissue_expression_down	hsa-mir-145	Meningioma	23108408	disease of cellular proliferation	DOID:3565	D32.9	D008579	607174	HP:0002858	miRNA-145 is downregulated in atypical and anaplastic meningiomas and negatively regulates motility and proliferation of meningioma cells
tissue_expression_down	hsa-mir-219	Meningioma	22674195	disease of cellular proliferation	DOID:3565	D32.9	D008579	607174	HP:0002858	Downregulation of miR-29c-3p and miR-219-5p were found to be associated with advanced clinical stages of meningioma. Kaplan-Meier analysis showed that high expression of miR-190a and low expression of miR-29c-3p and miR-219-5p correlated significantly with higher recurrence rates in meningioma patients.
tissue_expression_down	hsa-mir-29c	Meningioma	22674195	disease of cellular proliferation	DOID:3565	D32.9	D008579	607174	HP:0002858	Downregulation of miR-29c-3p and miR-219-5p were found to be associated with advanced clinical stages of meningioma. Kaplan-Meier analysis showed that high expression of miR-190a and low expression of miR-29c-3p and miR-219-5p correlated significantly with higher recurrence rates in meningioma patients.
tissue_expression_down	hsa-mir-30c-1	Mesothelioma	21317924	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	Hsa-miR-17* was significantly upregulated and hsa-miR-30c was significantly downregulated by Onconase treatment in all cell lines
tissue_expression_down	hsa-mir-30c-2	Mesothelioma	21317924	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	Hsa-miR-17* was significantly upregulated and hsa-miR-30c was significantly downregulated by Onconase treatment in all cell lines
tissue_expression_down	hsa-mir-144	Mitochondrial Metabolism Disease	27329039	disease of metabolism	DOID:700	E88.40	D028361			down-regulation of miR-144-3p expression
tissue_expression_down	hsa-mir-194	Multiple Myeloma	25092124	disease of cellular proliferation	DOID:9538		D009101	254500	HP:0006775	We determined that the relative expression levels of miR-15a/16, miR-34a, miR-194 in MM patients were significantly lower than those in the healthy controls
tissue_expression_down	hsa-mir-194	Multiple Myeloma	25778888	disease of cellular proliferation	DOID:9538		D009101	254500	HP:0006775	The expression of miR-15a/16,miR-34a,miR-194-2-192 cluster in MM patients were significantly lower than those of the health controls, while miR-181a/b were exactly the reverse (P<0.05).
tissue_expression_down	hsa-mir-15a	Multiple Sclerosis	22463747	nervous system disease	DOID:2377	G35	D009103	PS126200		miR-15a and 16-1 are downregulated in CD4(+) T cells of multiple sclerosis relapsing patients.
tissue_expression_down	hsa-mir-16-1	Multiple Sclerosis	22463747	nervous system disease	DOID:2377	G35	D009103	PS126200		miR-15a and 16-1 are downregulated in CD4(+) T cells of multiple sclerosis relapsing patients.
tissue_expression_down	hsa-mir-17	Multiple Sclerosis	20711463	nervous system disease	DOID:2377	G35	D009103	PS126200		In all MS subtypes miR-17 and miR-20a were significantly under-expressed in MS, confirmed by RT-PCR. 
tissue_expression_down	hsa-mir-20a	Multiple Sclerosis	20711463	nervous system disease	DOID:2377	G35	D009103	PS126200		In all MS subtypes miR-17 and miR-20a were significantly under-expressed in MS, confirmed by RT-PCR. 
tissue_expression_down	hsa-mir-223	Muscular Dystrophy	26398013			G71.0	D009136	310200	HP:0003560	higher levels of cytokines appear to inhibit myogenic miRNAs in muscle and artificially reducing levels of miR-223 increases protein kinase C-epsilon (PKC蔚) levels in keratinocytes.
tissue_expression_down	hsa-mir-25	Muscular Dystrophy, Facioscapulohumeral	24145033	musculoskeletal system disease	DOID:11727	G71.0	D020391	158900		eight were down-regulated (miR-15b, miR-20b, miR-21, miR-25, miR-100, miR-155, miR-345, and miR-594)
tissue_expression_down	hsa-mir-1-1	Musculoskeletal Abnormalities [unspecific]	17917533				D009139			Studies performed to determine whether skeletal muscle hypertrophy affects miRNA expression showed that miR-1 and miR-133 were decreased, suggesting that these muscle-specific miRNAs may contribute to regulating the initial response of skeletal muscle to functional overload.
tissue_expression_down	hsa-mir-1-2	Musculoskeletal Abnormalities [unspecific]	17917533				D009139			Studies performed to determine whether skeletal muscle hypertrophy affects miRNA expression showed that miR-1 and miR-133 were decreased, suggesting that these muscle-specific miRNAs may contribute to regulating the initial response of skeletal muscle to functional overload.
tissue_expression_down	hsa-mir-133a-1	Musculoskeletal Abnormalities [unspecific]	17917533				D009139			Studies performed to determine whether skeletal muscle hypertrophy affects miRNA expression showed that miR-1 and miR-133 were decreased, suggesting that these muscle-specific miRNAs may contribute to regulating the initial response of skeletal muscle to functional overload.
tissue_expression_down	hsa-mir-133a-2	Musculoskeletal Abnormalities [unspecific]	17917533				D009139			Studies performed to determine whether skeletal muscle hypertrophy affects miRNA expression showed that miR-1 and miR-133 were decreased, suggesting that these muscle-specific miRNAs may contribute to regulating the initial response of skeletal muscle to functional overload.
tissue_expression_down	hsa-mir-206	Musculoskeletal Abnormalities [unspecific]	17917533				D009139			Studies to evaluate the role of miRNAs in muscular dystrophy showed a dramatic increase in miR-206 expression in the diaphragm of the mdx mouse.
tissue_expression_down	hsa-let-7a-1	Mycosis Fungoides	21966986			C84.00	D009182			MiR-155 was only found to be slightly overexpressed in MF compared to healthy controls. Furthermore, metastatic MF demonstrated lower concentrations of let-7a, let-7d and let-7f when compared to MF limited to the skin.
tissue_expression_down	hsa-let-7a-2	Mycosis Fungoides	21966986			C84.00	D009182			MiR-155 was only found to be slightly overexpressed in MF compared to healthy controls. Furthermore, metastatic MF demonstrated lower concentrations of let-7a, let-7d and let-7f when compared to MF limited to the skin.
tissue_expression_down	hsa-let-7a-3	Mycosis Fungoides	21966986			C84.00	D009182			MiR-155 was only found to be slightly overexpressed in MF compared to healthy controls. Furthermore, metastatic MF demonstrated lower concentrations of let-7a, let-7d and let-7f when compared to MF limited to the skin.
tissue_expression_down	hsa-let-7d	Mycosis Fungoides	21966986			C84.00	D009182			MiR-155 was only found to be slightly overexpressed in MF compared to healthy controls. Furthermore, metastatic MF demonstrated lower concentrations of let-7a, let-7d and let-7f when compared to MF limited to the skin.
tissue_expression_down	hsa-let-7f-1	Mycosis Fungoides	21966986			C84.00	D009182			MiR-155 was only found to be slightly overexpressed in MF compared to healthy controls. Furthermore, metastatic MF demonstrated lower concentrations of let-7a, let-7d and let-7f when compared to MF limited to the skin.
tissue_expression_down	hsa-let-7f-2	Mycosis Fungoides	21966986			C84.00	D009182			MiR-155 was only found to be slightly overexpressed in MF compared to healthy controls. Furthermore, metastatic MF demonstrated lower concentrations of let-7a, let-7d and let-7f when compared to MF limited to the skin.
tissue_expression_down	hsa-mir-145	Myelodysplastic Syndromes	24627193	disease of cellular proliferation	DOID:0050908	D46.9	D009190	614286	HP:0002863	Other pathogenetic elements include protein phosphatase 2a and CDC25C haplodeficiency and decreased miR-145 and miR-146a expression.
tissue_expression_down	hsa-mir-146a	Myelodysplastic Syndromes	21211043	disease of cellular proliferation	DOID:0050908	D46.9	D009190	614286	HP:0002863	miR-378 and miR-146a showed reduced gene expression in the patients.
tissue_expression_down	hsa-mir-146a	Myelodysplastic Syndromes	24627193	disease of cellular proliferation	DOID:0050908	D46.9	D009190	614286	HP:0002863	Other pathogenetic elements include protein phosphatase 2a and CDC25C haplodeficiency and decreased miR-145 and miR-146a expression.
tissue_expression_down	hsa-mir-155	Myelodysplastic Syndromes	22371183	disease of cellular proliferation	DOID:0050908	D46.9	D009190	614286	HP:0002863	Real-time PCR approach confirmed that mir-155, miR-181a and miR-222 were down-expressed in mesenchymal stromal cells from myelodysplastic syndrome patients.
tissue_expression_down	hsa-mir-181a-1	Myelodysplastic Syndromes	22371183	disease of cellular proliferation	DOID:0050908	D46.9	D009190	614286	HP:0002863	Real-time PCR approach confirmed that mir-155, miR-181a and miR-222 were down-expressed in mesenchymal stromal cells from myelodysplastic syndrome patients.
tissue_expression_down	hsa-mir-181a-2	Myelodysplastic Syndromes	22371183	disease of cellular proliferation	DOID:0050908	D46.9	D009190	614286	HP:0002863	Real-time PCR approach confirmed that mir-155, miR-181a and miR-222 were down-expressed in mesenchymal stromal cells from myelodysplastic syndrome patients.
tissue_expression_down	hsa-mir-222	Myelodysplastic Syndromes	22371183	disease of cellular proliferation	DOID:0050908	D46.9	D009190	614286	HP:0002863	Real-time PCR approach confirmed that mir-155, miR-181a and miR-222 were down-expressed in mesenchymal stromal cells from myelodysplastic syndrome patients.
tissue_expression_down	hsa-mir-29b	Myelodysplastic Syndromes	27020498	disease of cellular proliferation	DOID:0050908	D46.9	D009190	614286	HP:0002863	MiR-29b expression was down-regulated in refractory anaemia and OL bone marrow as compared to that in control bone marrow.
tissue_expression_down	hsa-mir-378a	Myelodysplastic Syndromes	21211043	disease of cellular proliferation	DOID:0050908	D46.9	D009190	614286	HP:0002863	miR-378 and miR-146a showed reduced gene expression in the patients.
tissue_expression_down	hsa-mir-21	Myeloma	25000828			C90.0	D009101	254500		Our results suggest that berberine suppresses multiple myeloma cell growth, at least in part, by down-regulating miR-21 levels possibly through IL6/STAT3. This led to increased PDCD4 expression, which is likely to result in suppression of the p53 signaling pathway. These findings may also provide new mechanistic insight into the anti-cancer effects of certain compounds in traditional Chinese herbal medicines.
tissue_expression_down	hsa-mir-1	Myocardial Infarction	26253453	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	Compared with the CON group, miR-1 was downregulated, whereas miR-21 was upregulated, and BCL2 messenger RNA (mRNA) was upregulated, whereas BAX mRNA and  programmed cell death 4 mRNA remained unchanged in the IPO group.
tissue_expression_down	hsa-mir-1	Myocardial Infarction	26646371	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	MicroRNA-1 and -214 expressions were, respectively, decreased (52 %) and increased (54 %) in the S-INF compared to the S-SHAM, while exercise training normalized the expression of these microRNAs.
tissue_expression_down	hsa-mir-1	Myocardial Infarction	29162889	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly
tissue_expression_down	hsa-mir-126	Myocardial Infarction	20187981	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	we found that AMI is associated with altered miRNA expression level and the differentially expressed miRNAs may be novel biomarkers of AMI
tissue_expression_down	hsa-mir-126	Myocardial Infarction	25064220	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	miR-126 expression in ischemia-reperfusion group was significantly lower than in sham operation group
tissue_expression_down	hsa-mir-126	Myocardial Infarction	29642385	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	Moreover, the expression level of miR-126 tended to be downregulated and that of miR-21 tended to be upregulated in ApoE KO mice exposed to the high dose of CS, albeit statistically insignificant
tissue_expression_down	hsa-mir-133b	Myocardial Infarction	20029200	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	downregulated
tissue_expression_down	hsa-mir-150	Myocardial Infarction	22048267	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	Comparing MI patients with VR and those without VR, we found miR-146a up-regulation, and miR-150 and miR-155 down-regulation in patients with VR. In conclusion, our study demonstrated an altered expression of miR-146a, miR-150, and miR-155 in MI compared to the normal hearts.
tissue_expression_down	hsa-mir-150	Myocardial Infarction	23326587	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	Adenosine increases the migration of EPC. The mechanism involves A(2B) receptor activation, decreased expression of miR-150 and increased expression of CXCR4.
tissue_expression_down	hsa-mir-150	Myocardial Infarction	27184887	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	miR-150 is downregulated in cardiovascular diseases, such as acute myocardial infarction
tissue_expression_down	hsa-mir-155	Myocardial Infarction	22048267	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	Comparing MI patients with VR and those without VR, we found miR-146a up-regulation, and miR-150 and miR-155 down-regulation in patients with VR. In conclusion, our study demonstrated an altered expression of miR-146a, miR-150, and miR-155 in MI compared to the normal hearts.
tissue_expression_down	hsa-mir-223	Myocardial Infarction	29162889	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly
tissue_expression_down	hsa-mir-31	Myocardial Infarction	20187981	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	we found that AMI is associated with altered miRNA expression level and the differentially expressed miRNAs may be novel biomarkers of AMI
tissue_expression_down	hsa-mir-499a	Myocardial Infarction	20187981	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	miR-499-5p; we found that AMI is associated with altered miRNA expression level and the differentially expressed miRNAs may be novel biomarkers of AMI
tissue_expression_down	hsa-mir-92a	Myocardial Infarction	29162889	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly
tissue_expression_down	hsa-mir-99a	Myocardial Infarction	29162889	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly
tissue_expression_down	hsa-mir-1	Myositis	24757153	musculoskeletal system disease	DOID:633	G72.49	D009220	160750	HP:0100614	We observed decreased expression of microRNA-1 (miR-1), miR-133a, and miR-133b in all of the inflammatory myopathy subtypes we evaluated, as well as decreased expression of miR-206 in DM;
tissue_expression_down	hsa-mir-125b-1	Myotonic Muscular Dystrophy	22768114			G71.11	D009223	160900		miR-125b-5p: decreased levels compared to controls
tissue_expression_down	hsa-mir-193a	Myotonic Muscular Dystrophy	22768114			G71.11	D009223	160900		miR-193a-3p: decreased levels compared to controls
tissue_expression_down	hsa-mir-193b	Myotonic Muscular Dystrophy	22768114			G71.11	D009223	160900		miR-193b-3p: decreased levels compared to controls
tissue_expression_down	hsa-mir-29b-1	Myotonic Muscular Dystrophy	21169019			G71.11	D009223	160900		We found that miR-1 and miR-335 were up-regulated, whereas miR-29b and c, and miR-33 were down-regulated in DM1 biopsies compared to controls.
tissue_expression_down	hsa-mir-29b-2	Myotonic Muscular Dystrophy	21169019			G71.11	D009223	160900		We found that miR-1 and miR-335 were up-regulated, whereas miR-29b and c, and miR-33 were down-regulated in DM1 biopsies compared to controls.
tissue_expression_down	hsa-mir-29c	Myotonic Muscular Dystrophy	21169019			G71.11	D009223	160900		We found that miR-1 and miR-335 were up-regulated, whereas miR-29b and c, and miR-33 were down-regulated in DM1 biopsies compared to controls.
tissue_expression_down	hsa-mir-33a	Myotonic Muscular Dystrophy	21169019			G71.11	D009223	160900		We found that miR-1 and miR-335 were up-regulated, whereas miR-29b and c, and miR-33 were down-regulated in DM1 biopsies compared to controls.
tissue_expression_down	hsa-mir-33b	Myotonic Muscular Dystrophy	21169019			G71.11	D009223	160900		We found that miR-1 and miR-335 were up-regulated, whereas miR-29b and c, and miR-33 were down-regulated in DM1 biopsies compared to controls.
tissue_expression_down	hsa-mir-378a	Myotonic Muscular Dystrophy	22768114			G71.11	D009223	160900		miR-378a-3p: decreased levels compared to controls
tissue_expression_down	hsa-let-7a-1	Nasopharyngeal Neoplasms	21373758			C11.9	D009303	607107	HP:0100630	underexpressed
tissue_expression_down	hsa-let-7a-2	Nasopharyngeal Neoplasms	21373758			C11.9	D009303	607107	HP:0100630	underexpressed
tissue_expression_down	hsa-let-7a-3	Nasopharyngeal Neoplasms	21373758			C11.9	D009303	607107	HP:0100630	underexpressed
tissue_expression_down	hsa-let-7b	Nasopharyngeal Neoplasms	21373758			C11.9	D009303	607107	HP:0100630	underexpressed
tissue_expression_down	hsa-let-7c	Nasopharyngeal Neoplasms	21373758			C11.9	D009303	607107	HP:0100630	underexpressed
tissue_expression_down	hsa-let-7d	Nasopharyngeal Neoplasms	21373758			C11.9	D009303	607107	HP:0100630	underexpressed
tissue_expression_down	hsa-let-7e	Nasopharyngeal Neoplasms	21373758			C11.9	D009303	607107	HP:0100630	underexpressed
tissue_expression_down	hsa-let-7f-1	Nasopharyngeal Neoplasms	21373758			C11.9	D009303	607107	HP:0100630	underexpressed
tissue_expression_down	hsa-let-7f-2	Nasopharyngeal Neoplasms	21373758			C11.9	D009303	607107	HP:0100630	underexpressed
tissue_expression_down	hsa-let-7g	Nasopharyngeal Neoplasms	21373758			C11.9	D009303	607107	HP:0100630	underexpressed
tissue_expression_down	hsa-let-7i	Nasopharyngeal Neoplasms	21373758			C11.9	D009303	607107	HP:0100630	underexpressed
tissue_expression_down	hsa-mir-34b	Nasopharyngeal Neoplasms	21373758			C11.9	D009303	607107	HP:0100630	underexpressed
tissue_expression_down	hsa-mir-34c	Nasopharyngeal Neoplasms	21373758			C11.9	D009303	607107	HP:0100630	underexpressed
tissue_expression_down	hsa-let-7a-1	Neoplasms [unspecific]	17028596			C80.1	D009369			let-7a-1 downregulated in six solid cancer types by PAM and SAM (Volinia et al., 2006);
tissue_expression_down	hsa-let-7a-2	Neoplasms [unspecific]	17028596			C80.1	D009369			Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control.
tissue_expression_down	hsa-let-7a-3	Neoplasms [unspecific]	17028596			C80.1	D009369			Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control.
tissue_expression_down	hsa-let-7b	Neoplasms [unspecific]	17028596			C80.1	D009369			Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control.
tissue_expression_down	hsa-let-7c	Neoplasms [unspecific]	17028596			C80.1	D009369			Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control.
tissue_expression_down	hsa-let-7d	Neoplasms [unspecific]	17028596			C80.1	D009369			Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control.
tissue_expression_down	hsa-let-7e	Neoplasms [unspecific]	17028596			C80.1	D009369			Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control.
tissue_expression_down	hsa-let-7f-1	Neoplasms [unspecific]	17028596			C80.1	D009369			Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control.
tissue_expression_down	hsa-let-7f-2	Neoplasms [unspecific]	17028596			C80.1	D009369			Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control.
tissue_expression_down	hsa-let-7g	Neoplasms [unspecific]	17028596			C80.1	D009369			Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control.
tissue_expression_down	hsa-let-7i	Neoplasms [unspecific]	17028596			C80.1	D009369			Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control.
tissue_expression_down	hsa-mir-103a-1	Neoplasms [unspecific]	20439436			C80.1	D009369			miR-103:hsa-miR-103/106 were downgraded in cancer, whereas hsa-miR-30 became most prominent
tissue_expression_down	hsa-mir-103a-2	Neoplasms [unspecific]	20439436			C80.1	D009369			miR-103:hsa-miR-103/106 were downgraded in cancer, whereas hsa-miR-30 became most prominent
tissue_expression_down	hsa-mir-106a	Neoplasms [unspecific]	20439436			C80.1	D009369			miR-106:hsa-miR-103/106 were downgraded in cancer, whereas hsa-miR-30 became most prominent
tissue_expression_down	hsa-mir-10a	Neoplasms [unspecific]	20145181			C80.1	D009369			downregulation
tissue_expression_down	hsa-mir-10b	Neoplasms [unspecific]	20145181			C80.1	D009369			downregulation
tissue_expression_down	hsa-mir-125b	Neoplasms [unspecific]	24774301			C80.1	D009369			Thus, in different tumor entities increased or decreased miR-125b expression may contribute to carcinogenesis.
tissue_expression_down	hsa-mir-125b-1	Neoplasms [unspecific]	20145181			C80.1	D009369			underexpression
tissue_expression_down	hsa-mir-125b-2	Neoplasms [unspecific]	20145181			C80.1	D009369			underexpression
tissue_expression_down	hsa-mir-138	Neoplasms [unspecific]	24057215			C80.1	D009369			MiR-138 downregulates miRNA processing in HeLa cells by targeting RMND5A and decreasing Exportin-5 stability.
tissue_expression_down	hsa-mir-143	Neoplasms [unspecific]	19175697			C80.1	D009369			The expression of a subset of miRs (e.g. miR-21 and miR-155) was found to be consistently up-regulated, whereas another subset of miRs (e.g.miR-143 and miR-145) was consistently down-regulated across different cancer types suggesting their involvement in regulating common cellular processes whose deregulation may lead to tumourigenesis.
tissue_expression_down	hsa-mir-145	Neoplasms [unspecific]	19676045			C80.1	D009369			down-regulated
tissue_expression_down	hsa-mir-145	Neoplasms [unspecific]	20370992			C80.1	D009369			under-expressed
tissue_expression_down	hsa-mir-145	Neoplasms [unspecific]	19175697			C80.1	D009369			The expression of a subset of miRs (e.g. miR-21 and miR-155) was found to be consistently up-regulated, whereas another subset of miRs (e.g.miR-143 and miR-145) was consistently down-regulated across different cancer types suggesting their involvement in regulating common cellular processes whose deregulation may lead to tumourigenesis.
tissue_expression_down	hsa-mir-149	Neoplasms [unspecific]	19676045			C80.1	D009369			down-regulated
tissue_expression_down	hsa-mir-153-1	Neoplasms [unspecific]	23188671			C80.1	D009369			Downregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancer
tissue_expression_down	hsa-mir-153-2	Neoplasms [unspecific]	23188671			C80.1	D009369			Downregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancer
tissue_expression_down	hsa-mir-155	Neoplasms [unspecific]	20370992			C80.1	D009369			under-expressed
tissue_expression_down	hsa-mir-182	Neoplasms [unspecific]	19676045			C80.1	D009369			down-regulated
tissue_expression_down	hsa-mir-184	Neoplasms [unspecific]	19676045			C80.1	D009369			down-regulated
tissue_expression_down	hsa-mir-192	Neoplasms [unspecific]	19074876			C80.1	D009369			Our results showing a role for miR-192/215 in cell proliferation combined with recent observations that these miRNAs are underexpressed in primary cancers support the idea that miR-192 and miR-215 function as tumor suppressors.
tissue_expression_down	hsa-mir-199a-1	Neoplasms [unspecific]	23060436			C80.1	D009369			The microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway
tissue_expression_down	hsa-mir-199a-2	Neoplasms [unspecific]	23060436			C80.1	D009369			The microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway
tissue_expression_down	hsa-mir-200	Neoplasms [unspecific]	24282096			C80.1	D009369			The EMT-suppressive miR-203 and miR-200 family were consistently but non-significantly downregulated in CUP with the EMT phenotype. A larger study is warranted to further explore the role of microRNAs in CUP.
tissue_expression_down	hsa-mir-200a	Neoplasms [unspecific]	20484038			C80.1	D009369			miR-200a:Downregulation of microRNA-200 in EBV-associated gastric carcinoma
tissue_expression_down	hsa-mir-200a	Neoplasms [unspecific]	26198058			C80.1	D009369			miR-23b, miR-199a, and miR-15a displayed increased expression during early AVC development whereas others such as miR-130a and miR-200a display decreased expression levels
tissue_expression_down	hsa-mir-200b	Neoplasms [unspecific]	20484038			C80.1	D009369			miR-200b:Downregulation of microRNA-200 in EBV-associated gastric carcinoma
tissue_expression_down	hsa-mir-200c	Neoplasms [unspecific]	20484038			C80.1	D009369			miR-200c:Downregulation of microRNA-200 in EBV-associated gastric carcinoma
tissue_expression_down	hsa-mir-203	Neoplasms [unspecific]	24282096			C80.1	D009369			The EMT-suppressive miR-203 and miR-200 family were consistently but non-significantly downregulated in CUP with the EMT phenotype. A larger study is warranted to further explore the role of microRNAs in CUP.
tissue_expression_down	hsa-mir-205	Neoplasms [unspecific]	19676045			C80.1	D009369			down-regulated
tissue_expression_down	hsa-mir-215	Neoplasms [unspecific]	19074876			C80.1	D009369			Our results showing a role for miR-192/215 in cell proliferation combined with recent observations that these miRNAs are underexpressed in primary cancers support the idea that miR-192 and miR-215 function as tumor suppressors.
tissue_expression_down	hsa-mir-221	Neoplasms [unspecific]	19676045			C80.1	D009369			down-regulated
tissue_expression_down	hsa-mir-222	Neoplasms [unspecific]	19676045			C80.1	D009369			down-regulated
tissue_expression_down	hsa-mir-30c-1	Neoplasms [unspecific]	23318178			C80.1	D009369			Sulfuretin-induced miR-30C selectively downregulates cyclin D1 and D2 and triggers cell death in human cancer cell lines
tissue_expression_down	hsa-mir-30c-2	Neoplasms [unspecific]	23318178			C80.1	D009369			Sulfuretin-induced miR-30C selectively downregulates cyclin D1 and D2 and triggers cell death in human cancer cell lines
tissue_expression_down	hsa-mir-30d	Neoplasms [unspecific]	17028596			C80.1	D009369			mir-30d downregulated in six solid cancer types by SAM (Volinia et al., 2006);
tissue_expression_down	hsa-mir-31	Neoplasms [unspecific]	19676045			C80.1	D009369			down-regulated
tissue_expression_down	hsa-mir-375	Neoplasms [unspecific]	20145181			C80.1	D009369			underexpression
tissue_expression_down	hsa-mir-375	Neoplasms [unspecific]	20215506			C80.1	D009369			MicroRNA-375 is downregulated in gastric carcinomas
tissue_expression_down	hsa-mir-452	Neoplasms [unspecific]	25040964			C80.1	D009369			Down-regulation of miRNA-452 is associated with adriamycin-resistance in breast cancer cells.
tissue_expression_down	hsa-mir-92a-1	Neoplasms [unspecific]	17028596			C80.1	D009369			mir-92 downregulated in six solid cancer types by PAM (Volinia et al., 2006)
tissue_expression_down	hsa-mir-92a-2	Neoplasms [unspecific]	17028596			C80.1	D009369			mir-92 downregulated in six solid cancer types by PAM (Volinia et al., 2006)
tissue_expression_down	hsa-mir-92b	Neoplasms [unspecific]	17028596			C80.1	D009369			mir-92 downregulated in six solid cancer types by PAM (Volinia et al., 2006)
tissue_expression_down	hsa-mir-98	Neoplasms [unspecific]	17028596			C80.1	D009369			Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control.
tissue_expression_down	hsa-mir-99a	Neoplasms [unspecific]	21383697			C80.1	D009369			miR-99a-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways.
tissue_expression_down	hsa-mir-15a	Nephrotic Syndrome	28299339	urinary system disease	DOID:1184	N04	D009404	PS256300	HP:0000100	low expression levels of miR-15a and miR-16-1 were found compared with  healthy controls, but only the miR-16-1 expression levels showed statistically significant decrease
tissue_expression_down	hsa-mir-16	Nephrotic Syndrome	28299339	urinary system disease	DOID:1184	N04	D009404	PS256300	HP:0000100	low expression levels of miR-15a and miR-16-1 were found compared with  healthy controls, but only the miR-16-1 expression levels showed statistically significant decrease
tissue_expression_down	hsa-mir-7	Nervous System Diseases [unspecific]	26647301			C72.9	D009422			We showed, for the first time in LUHMES, down-regulation of mir-7, a miRNA known to target alpha-synuclein and to be involved in PD.
tissue_expression_down	hsa-mir-106b	Neuroblastoma	22498172	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)
tissue_expression_down	hsa-mir-146b	Neuroblastoma	22244746	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	under-expressed in mature neuron.
tissue_expression_down	hsa-mir-152	Neuroblastoma	22244746	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	under-expressed in mature neuron.
tissue_expression_down	hsa-mir-204	Neuroblastoma	26145533	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	miR-204 mediates post-transcriptional down-regulation of PHOX2B gene expression in neuroblastoma cells.
tissue_expression_down	hsa-mir-29a	Neuroblastoma	24898736	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Deep MicroRNA sequencing reveals downregulation of miR-29a in neuroblastoma central nervous system metastasis.
tissue_expression_down	hsa-mir-339	Neuroblastoma	22244746	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	miR-339-5p: under-expressed in mature neuron.
tissue_expression_down	hsa-mir-370	Neuroblastoma	22244746	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	under-expressed in neuroblastoma.
tissue_expression_down	hsa-mir-410	Neuroblastoma	21970883	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Two, miR-487b and miR-410, were significantly downregulated in the high-risk group. Multivariable analyses showed miR-487b expression as associated with overall survival and disease-free survival in the whole cohort, independently of clinical covariates. Moreover, miR-487b and miR-410 expression was significantly associated with disease-free survival of the non-MYCN-amplified favourable neuroblastoma: localised (stage 1, 2 and 3) and stage 4 of infant <18 months.Conclusion:Expression of miR-487b and miR-410 shows predictive value beyond the classical high-/low-risk stratification and is a biomarker of relapse in favourable neuroblastoma.
tissue_expression_down	hsa-mir-487b	Neuroblastoma	21970883	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Two, miR-487b and miR-410, were significantly downregulated in the high-risk group. Multivariable analyses showed miR-487b expression as associated with overall survival and disease-free survival in the whole cohort, independently of clinical covariates. Moreover, miR-487b and miR-410 expression was significantly associated with disease-free survival of the non-MYCN-amplified favourable neuroblastoma: localised (stage 1, 2 and 3) and stage 4 of infant <18 months.Conclusion:Expression of miR-487b and miR-410 shows predictive value beyond the classical high-/low-risk stratification and is a biomarker of relapse in favourable neuroblastoma.
tissue_expression_down	hsa-mir-9-1	Neuroblastoma	22244746	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	under-expressed in neuroblastoma.
tissue_expression_down	hsa-mir-9-2	Neuroblastoma	22244746	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	under-expressed in neuroblastoma.
tissue_expression_down	hsa-mir-92a-1	Neuroblastoma	22498172	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)
tissue_expression_down	hsa-mir-92a-2	Neuroblastoma	22498172	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)
tissue_expression_down	hsa-mir-92b	Neuroblastoma	22498172	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)
tissue_expression_down	hsa-mir-93	Neuroblastoma	22498172	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)
tissue_expression_down	hsa-mir-9-3	Neuroblastoma	22244746	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	under-expressed in neuroblastoma.
tissue_expression_down	hsa-mir-19	Neurodegenerative Diseases [unspecific]	26836165				D019636		HP:0002180	along with downregulation of miR-19a/miR-19b,
tissue_expression_down	hsa-mir-21	Neuroma	20856158	disease of cellular proliferation	DOID:2001		D009463			miR-21:Elevated levels of hsa-microRNA-21 (miR-21) in vestibular schwannomas (VSs) may contribute to tumor growth by downregulating the tumor suppressor phosphatase and tensin homolog (PTEN) and consequent hyperactivation of protein kinase B
tissue_expression_down	hsa-mir-145	NUT Midline Carcinoma	29322795	disease of cellular proliferation	DOID:0060463					All NMCs showed upregulation of miR-9 and downregulation of miR-99a and miR-145 and two cases featured also upregulation of miR-21, miR-143, and miR-484
tissue_expression_down	hsa-mir-99a	NUT Midline Carcinoma	29322795	disease of cellular proliferation	DOID:0060463					All NMCs showed upregulation of miR-9 and downregulation of miR-99a and miR-145 and two cases featured also upregulation of miR-21, miR-143, and miR-484
tissue_expression_down	hsa-mir-146a	Obesity	28652200	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Down-regulation of miRNAs in the brain and development of diet-induced obesity
tissue_expression_down	hsa-mir-155	Obesity	28652200	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Down-regulation of miRNAs in the brain and development of diet-induced obesity.
tissue_expression_down	hsa-mir-26b	Obesity	25999046	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Decreased miR-26b expression in VAT may be involved in obesity-related IR by interrupting the PTEN/PI3K/AKT pathway.
tissue_expression_down	hsa-mir-125b	Oral Lichen Planus	27133077			L43.9	D017676		HP:0031453	MMP-2 expression was up-regulated and miR-125b expression was down-regulated in both OLP mucosa tissues and LPS-incubated HaCaT cells.
tissue_expression_down	hsa-mir-132	Osteoarthritis	20470394	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	In RA and OA, synovial fluid concentrations of miR-16, miR-132, miR-146a, and miR-223 were significantly lower than their plasma concentrations, and there were no correlation between plasma and synovial fluid miRNAs.
tissue_expression_down	hsa-mir-140	Osteoarthritis	19714579	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	down-regulated IL-1beta-induced ADAMTS5
tissue_expression_down	hsa-mir-146a	Osteoarthritis	20470394	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	In RA and OA, synovial fluid concentrations of miR-16, miR-132, miR-146a, and miR-223 were significantly lower than their plasma concentrations, and there were no correlation between plasma and synovial fluid miRNAs.
tissue_expression_down	hsa-mir-146a	Osteoarthritis	23744481	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	The downregulation of miR-146a and/or the miR-183 cluster in the central compartments (DRG and spinal cord) are closely associated with the upregulation of inflammatory pain mediators.
tissue_expression_down	hsa-mir-146a	Osteoarthritis	25598697	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	This miR is considered a biological marker for cartilage and its level significantly decreases in OA cartilage.
tissue_expression_down	hsa-mir-15a	Osteoarthritis	26707794	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	hsa鈥憁iR鈥?5a expression was downregulated
tissue_expression_down	hsa-mir-16	Osteoarthritis	20470394	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	In RA and OA, synovial fluid concentrations of miR-16, miR-132, miR-146a, and miR-223 were significantly lower than their plasma concentrations, and there were no correlation between plasma and synovial fluid miRNAs.
tissue_expression_down	hsa-mir-183	Osteoarthritis	23744481	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	The downregulation of miR-146a and/or the miR-183 cluster in the central compartments (DRG and spinal cord) are closely associated with the upregulation of inflammatory pain mediators.
tissue_expression_down	hsa-mir-223	Osteoarthritis	20470394	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	In RA and OA, synovial fluid concentrations of miR-16, miR-132, miR-146a, and miR-223 were significantly lower than their plasma concentrations, and there were no correlation between plasma and synovial fluid miRNAs.
tissue_expression_down	hsa-mir-26a	Osteoarthritis	28000846	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	Reduced miR‑26a and miR‑26b expression contributes to the pathogenesis of osteoarthritis via the promotion of p65 translocation.
tissue_expression_down	hsa-mir-26b	Osteoarthritis	28000846	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	Reduced miR‑26a and miR‑26b expression contributes to the pathogenesis of osteoarthritis via the promotion of p65 translocation.
tissue_expression_down	hsa-mir-27b	Osteoarthritis	26505891	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	miR-146a significantly up-regulated and  miR-27b significantly down-regulated at all time points
tissue_expression_down	hsa-mir-675	Osteoarthritis	22527881	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	Proinflammatory cytokines IL-1beta and TNF-alpha downregulated COL2A1, H19, and miR-675 significantly without close statistical correlation.
tissue_expression_down	hsa-mir-29b	Osteogenesis Imperfecta	24767406	musculoskeletal system disease	DOID:12347	Q78.0	D010013	PS166200		COL1A1 and miR-29b show lower expression levels during osteoblast differentiation of bone marrow stromal cells from Osteogenesis Imperfecta patients.
tissue_expression_down	hsa-mir-27a	Osteoporosis	27337099	musculoskeletal system disease	DOID:11476	M80	D010024	166710	HP:0000939	miR-27a expression was significantly reduced in osteoporotic patients
tissue_expression_down	hsa-mir-132	Osteosarcoma	26352673	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	In conclusion, miR-132 inhibited cell growth and metastasis in osteosarcoma cells by downregulation of Sox4, and knockdown of Sox4 was essential for the miR-132-inhibited cell growth and metastasis in osteosarcoma cells.
tissue_expression_down	hsa-mir-133b	Osteosarcoma	24391788	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	MiR-133b is down-regulated in human osteosarcoma and inhibits osteosarcoma cells proliferation, migration and invasion, and promotes apoptosis.
tissue_expression_down	hsa-mir-142	Osteosarcoma	22350417	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	reduced expression
tissue_expression_down	hsa-mir-142	Osteosarcoma	25034529	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	MicroRNA-142-3p, a novel target of tumor suppressor menin, inhibits osteosarcoma cell proliferation by down-regulation of FASN.
tissue_expression_down	hsa-mir-144	Osteosarcoma	25318625	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	The downregulation of miR-144 is associated with the growth and invasion of osteosarcoma cells through the regulation of TAGLN expression.
tissue_expression_down	hsa-mir-16-1	Osteosarcoma	22350417	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	reduced expression
tissue_expression_down	hsa-mir-16-2	Osteosarcoma	22350417	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	reduced expression
tissue_expression_down	hsa-mir-199a-1	Osteosarcoma	21666078	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	MicroRNA-199a-3p Is Downregulated in Human Osteosarcoma and Regulates Cell Proliferation and Migration.
tissue_expression_down	hsa-mir-199a-2	Osteosarcoma	21666078	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	MicroRNA-199a-3p Is Downregulated in Human Osteosarcoma and Regulates Cell Proliferation and Migration.
tissue_expression_down	hsa-mir-210	Osteosarcoma	26044868	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	Downregulation of microRNA-210 inhibits osteosarcoma growth in vitro and in vivo.
tissue_expression_down	hsa-mir-22	Osteosarcoma	25953260	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	Downregulation of miR-22 acts as an unfavorable prognostic biomarker in osteosarcoma.
tissue_expression_down	hsa-mir-223	Osteosarcoma	23601845	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	we found that miRNA-223 was downregulated in both osteosarcoma patients' tumor tissues and osteosarcoma cell lines.
tissue_expression_down	hsa-mir-23a	Osteosarcoma	25619478	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	miR-23a functions as a tumor suppressor in osteosarcoma, and its inhibitory effect on tumor are mediated chiefly through downregulation of SATB1.
tissue_expression_down	hsa-mir-26a	Osteosarcoma	24452597	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	Downregulation of microRNA-26a is associated with metastatic potential and the poor prognosis of osteosarcoma patients.
tissue_expression_down	hsa-mir-26b	Osteosarcoma	25672572	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	miR-26b inhibits proliferation, migration, invasion and apoptosis induction via the downregulation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 driven glycolysis in osteosarcoma cells.
tissue_expression_down	hsa-mir-29b-1	Osteosarcoma	22350417	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	reduced expression
tissue_expression_down	hsa-mir-29b-2	Osteosarcoma	22350417	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	reduced expression
tissue_expression_down	hsa-mir-34a	Osteosarcoma	28260055	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	miR-34a is downregulated in human osteosarcoma stem-like cells and promotes invasion, tumorigenic ability and self-renewal capacity.
tissue_expression_down	hsa-mir-370	Osteosarcoma	26617733	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	In conclusion, miR-370 inhibited cell growth and metastasis in osteosarcoma cells by down-regulation of FOXM1.
tissue_expression_down	hsa-mir-449a	Osteosarcoma	26002578	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	miRNA-449a is downregulated in osteosarcoma and promotes cell apoptosis by targeting BCL2.
tissue_expression_down	hsa-mir-490	Osteosarcoma	28165565	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	Decreased expression of miR-490-3p in osteosarcoma and its clinical significance.
tissue_expression_down	hsa-mir-519d	Osteosarcoma	25003330	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	CTGF increases matrix metalloproteinases expression and subsequently promotes tumor metastasis in human osteosarcoma through down-regulating miR-519d.
tissue_expression_down	hsa-mir-586	Osteosarcoma	26580004	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	Downregulation of microRNA-586 Inhibits Proliferation, Invasion and Metastasis and Promotes Apoptosis in Human Osteosarcoma U2-OS Cell Line.
tissue_expression_down	hsa-mir-199a	Ovarian Germ Cell Cancer	29138809	endocrine system disease	DOID:2156			603737		Higher expression of miR-373-3p, miR-372-3p and miR-302c-3p and lower expression of miR-199a-5p, miR-214-5p and miR-202-3p were reproducibly observed in malignant OGCTs as compared to benign OGCTs or SCSTs
tissue_expression_down	hsa-mir-202	Ovarian Germ Cell Cancer	29138809	endocrine system disease	DOID:2156			603737		Higher expression of miR-373-3p, miR-372-3p and miR-302c-3p and lower expression of miR-199a-5p, miR-214-5p and miR-202-3p were reproducibly observed in malignant OGCTs as compared to benign OGCTs or SCSTs
tissue_expression_down	hsa-mir-214	Ovarian Germ Cell Cancer	29138809	endocrine system disease	DOID:2156			603737		Higher expression of miR-373-3p, miR-372-3p and miR-302c-3p and lower expression of miR-199a-5p, miR-214-5p and miR-202-3p were reproducibly observed in malignant OGCTs as compared to benign OGCTs or SCSTs
tissue_expression_down	hsa-let-7a-1	Ovarian Neoplasms	20035894	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	hsa-let-7a:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families
tissue_expression_down	hsa-let-7a-2	Ovarian Neoplasms	20035894	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	hsa-let-7a:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families
tissue_expression_down	hsa-let-7a-3	Ovarian Neoplasms	20035894	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	hsa-let-7a:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families
tissue_expression_down	hsa-let-7b	Ovarian Neoplasms	18451233	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	lower
tissue_expression_down	hsa-let-7b	Ovarian Neoplasms	20035894	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	hsa-let-7b:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families
tissue_expression_down	hsa-let-7c	Ovarian Neoplasms	20035894	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	hsa-let-7c:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families
tissue_expression_down	hsa-let-7c	Ovarian Neoplasms	21939554	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The miRNA was downregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines.
tissue_expression_down	hsa-let-7d	Ovarian Neoplasms	20035894	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	hsa-let-7d:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families
tissue_expression_down	hsa-let-7e	Ovarian Neoplasms	20035894	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	hsa-let-7e:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families
tissue_expression_down	hsa-let-7f-1	Ovarian Neoplasms	20035894	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	hsa-let-7f:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families
tissue_expression_down	hsa-let-7f-2	Ovarian Neoplasms	20035894	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	hsa-let-7f:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families
tissue_expression_down	hsa-let-7g	Ovarian Neoplasms	20035894	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	hsa-let-7g:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families
tissue_expression_down	hsa-let-7i	Ovarian Neoplasms	20035894	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	hsa-let-7i:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families
tissue_expression_down	hsa-let-7i	Ovarian Neoplasms	24479883	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Members of the miR-200 family, miR-182, miR-214 and miR-221 are frequently up-regulated, whereas miR-100, let-7i, miR-199a, miR-125b, mir-145 and miR-335 are often down-regulated in ovarian cancer compared with normal ovarian tissue.
tissue_expression_down	hsa-mir-100	Ovarian Neoplasms	22246341	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The level of miR-100 was significantly lower in EOC (epithelial ovarian cancer)  tissues compared to adjacent normal tissues. Low miR-100 expression was found to be closely correlated with advanced FIGO stage, higher serum CA125 expression level and lymph node involvement.
tissue_expression_down	hsa-mir-1202	Ovarian Neoplasms	22643117	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We found 37 differentially expressed miRNAs in the CD133(+) spheroid-forming subpopulation of OVCAR3 cells, 34 of which were significantly up-regulated, including miR-205, miR-146a, miR-200a, miR-200b, and miR-3, and 3 of which were significantly down-regulated, including miR-1202 and miR-1181.
tissue_expression_down	hsa-mir-125b	Ovarian Neoplasms	29307001	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-26a, miR-125b-5p, miR-17-5p and miR-221 downregulation could be related to poor EOC prognosis
tissue_expression_down	hsa-mir-125b-1	Ovarian Neoplasms	17875710	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs.
tissue_expression_down	hsa-mir-127	Ovarian Neoplasms	18954897	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-127: under-expression
tissue_expression_down	hsa-mir-1281	Ovarian Neoplasms	22643117	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We found 37 differentially expressed miRNAs in the CD133(+) spheroid-forming subpopulation of OVCAR3 cells, 34 of which were significantly up-regulated, including miR-205, miR-146a, miR-200a, miR-200b, and miR-3, and 3 of which were significantly down-regulated, including miR-1202 and miR-1181.
tissue_expression_down	hsa-mir-133b	Ovarian Neoplasms	19946373	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	downregulated
tissue_expression_down	hsa-mir-140	Ovarian Neoplasms	22452920	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The expression level of RAD51AP1 was found to be strongly anti-correlated with the expression of hsa-miR-140-3p, which was significantly down-regulated in the tumour samples.
tissue_expression_down	hsa-mir-141	Ovarian Neoplasms	19501389	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-200b-429 may be used as a prognostic marker for ovarian cancer outcome, and low-level expression of miR-200 miRNAs in this cluster predicts poor survival.
tissue_expression_down	hsa-mir-145	Ovarian Neoplasms	20716115	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets.
tissue_expression_down	hsa-mir-150	Ovarian Neoplasms	25986891	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miRNA-150 downregulation may contribute to the pertuzumab resistance in ovarian cancer via, at least in part, PI3K-akt pathway.
tissue_expression_down	hsa-mir-155	Ovarian Neoplasms	18954897	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-155: under-expression
tissue_expression_down	hsa-mir-15b	Ovarian Neoplasms	27195958	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	WNT7A Regulation by miR-15b in Ovarian Cancer.
tissue_expression_down	hsa-mir-17	Ovarian Neoplasms	29307001	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-26a, miR-125b-5p, miR-17-5p and miR-221 downregulation could be related to poor EOC prognosis
tissue_expression_down	hsa-mir-193b	Ovarian Neoplasms	25798837	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Microenvironment-induced downregulation of miR-193b drives ovarian cancer metastasis.
tissue_expression_down	hsa-mir-193b	Ovarian Neoplasms	26675282	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Reduction of miR-193b was found in ovarian cancer and its lower expression was associated with poorer prognosis. Tissue miR-193b showed potential as novel biomarker for ovarian cancer.
tissue_expression_down	hsa-mir-196b	Ovarian Neoplasms	29518404	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples
tissue_expression_down	hsa-mir-200	Ovarian Neoplasms	25347277	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Catalpol suppresses proliferation and facilitates apoptosis of OVCAR-3 ovariancancer cells through upregulating microRNA-200 and downregulating MMP-2expression.
tissue_expression_down	hsa-mir-200a	Ovarian Neoplasms	19501389	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-200b-429 may be used as a prognostic marker for ovarian cancer outcome, and low-level expression of miR-200 miRNAs in this cluster predicts poor survival.
tissue_expression_down	hsa-mir-200b	Ovarian Neoplasms	19501389	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-200b-429 may be used as a prognostic marker for ovarian cancer outcome, and low-level expression of miR-200 miRNAs in this cluster predicts poor survival.
tissue_expression_down	hsa-mir-200c	Ovarian Neoplasms	21345725	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-200c has potential as a predictor of survival, and is a biomarker of relapse, in stage I EOC.
tissue_expression_down	hsa-mir-200c	Ovarian Neoplasms	19501389	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-200b-429 may be used as a prognostic marker for ovarian cancer outcome, and low-level expression of miR-200 miRNAs in this cluster predicts poor survival.
tissue_expression_down	hsa-mir-205	Ovarian Neoplasms	24608381	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	VEGF is significantly expressed in the serum of epithelial ovarian cancer patients; and miR-205 is up-regulated in the epithelial ovarian cancer specimens. Ezrin and Lamin A/C are down-regulated in the epithelial ovarian cancer samples. VEGF, miR-205 and target protein may be associated with the invasion and metastasis of epithelial ovarian cancer.
tissue_expression_down	hsa-mir-205	Ovarian Neoplasms	25597268	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	VEGF promotes the invasion of ovarian cancer cells, partially via the down-regulation of Ezrin and Lamin A/C caused by increased expression of miR-205.
tissue_expression_down	hsa-mir-20b	Ovarian Neoplasms	21939554	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The miRNA was downregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines.
tissue_expression_down	hsa-mir-21	Ovarian Neoplasms	21968270	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-21 down-regulation promotes apoptosis and inhibits invasion and migration abilities of OVCAR3 (ovarian papillary adenocarcinoma cell lines) cells.
tissue_expression_down	hsa-mir-214	Ovarian Neoplasms	25483088	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	down-regulation of RNF8 mediated by miR-214 impedes DNA damage response to induce chromosomal instability in ovarian cancers, which may facilitate the understanding of mechanisms underlying chromosomal instability.
tissue_expression_down	hsa-mir-214	Ovarian Neoplasms	20716115	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets.
tissue_expression_down	hsa-mir-214	Ovarian Neoplasms	23171795	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We found that in ovarian CAFs, miR-31 and miR-214 were downregulated, whereas miR-155 was upregulated when compared with normal or tumor-adjacent fibroblasts.
tissue_expression_down	hsa-mir-214	Ovarian Neoplasms	23230184	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	They found that decreased miR-31 and miR-214 and increased miR-155 expression can reprogram normal fibroblasts into tumor-promoting cancer-associated fibroblasts.
tissue_expression_down	hsa-mir-221	Ovarian Neoplasms	29307001	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-26a, miR-125b-5p, miR-17-5p and miR-221 downregulation could be related to poor EOC prognosis
tissue_expression_down	hsa-mir-221	Ovarian Neoplasms	18560586	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	we identify several miRNAs aberrantly expressed in human ovarian cancer tissues and cell lines. miR-221 stands out as a highly elevated miRNA in ovarian cancer, while miR-21 and several members of the let-7 family are found downregulated.
tissue_expression_down	hsa-mir-26a	Ovarian Neoplasms	29307001	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-26a, miR-125b-5p, miR-17-5p and miR-221 downregulation could be related to poor EOC prognosis
tissue_expression_down	hsa-mir-27b	Ovarian Neoplasms	25823356	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-27b was identified as the most highly down-regulated miRNA in DGCR8 knockdown cells and promoted cell proliferation in ovarian cancer cells.
tissue_expression_down	hsa-mir-29b	Ovarian Neoplasms	24992675	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	BAG3 upregulates Mcl-1 through downregulation of miR-29b to induce anticancer drug resistance in ovarian cancer.
tissue_expression_down	hsa-mir-31	Ovarian Neoplasms	23171795	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We found that in ovarian CAFs, miR-31 and miR-214 were downregulated, whereas miR-155 was upregulated when compared with normal or tumor-adjacent fibroblasts.
tissue_expression_down	hsa-mir-31	Ovarian Neoplasms	23230184	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	They found that decreased miR-31 and miR-214 and increased miR-155 expression can reprogram normal fibroblasts into tumor-promoting cancer-associated fibroblasts.
tissue_expression_down	hsa-mir-34b	Ovarian Neoplasms	20145172	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	reduced expression of miR-34b*/c may be particularly important for progression to the most advanced stages
tissue_expression_down	hsa-mir-34c	Ovarian Neoplasms	21321636	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-449b and miR-34c on inducing down-regulation of cell cycle-related proteins and cycle arrests in SKOV3-ipl cell, an ovarian cancer cell line.
tissue_expression_down	hsa-mir-34c	Ovarian Neoplasms	20145172	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	reduced expression of miR-34b*/c may be particularly important for progression to the most advanced stages
tissue_expression_down	hsa-mir-429	Ovarian Neoplasms	19501389	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-200b-429 may be used as a prognostic marker for ovarian cancer outcome, and low-level expression of miR-200 miRNAs in this cluster predicts poor survival.
tissue_expression_down	hsa-mir-449a	Ovarian Neoplasms	25179844	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	MicroRNA-449a reduces cell survival and enhances cisplatin-induced cytotoxicity via downregulation of NOTCH1 in ovarian cancer cells.
tissue_expression_down	hsa-mir-486	Ovarian Neoplasms	19946373	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-486-5p: downregulated
tissue_expression_down	hsa-mir-498	Ovarian Neoplasms	26744867	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Decreased expression levels of miR-498 are associated with worse overall survival and poor prognosis in patients with ovarian cancer, highlighting potential usefulness of this miR for prognosis in patients with ovarian cancer.
tissue_expression_down	hsa-mir-499a	Ovarian Neoplasms	21321636	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-449b and miR-34c on inducing down-regulation of cell cycle-related proteins and cycle arrests in SKOV3-ipl cell, an ovarian cancer cell line.
tissue_expression_down	hsa-mir-532	Ovarian Neoplasms	29518404	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples
tissue_expression_down	hsa-mir-542	Ovarian Neoplasms	21939554	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The miRNA hsa-miR-542-3p was downregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines.
tissue_expression_down	hsa-mir-625	Ovarian Neoplasms	21939554	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The miRNA was downregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines.
tissue_expression_down	hsa-mir-886	Ovarian Neoplasms	29518404	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples
tissue_expression_down	hsa-mir-9	Ovarian Neoplasms	24168967	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-9 mediates the downregulation of BRCA1 and impedes DNA damage repair in ovarian cancer. miR-9 may improve chemotherapeutic efficacy by increasing the sensitivity of cancer cells to DNA damage and may impact ovarian cancer therapy.
tissue_expression_down	hsa-mir-99b	Ovarian Neoplasms	18954897	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-99b: under-expression
tissue_expression_down	hsa-mir-99b	Ovarian Neoplasms	29518404	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples
tissue_expression_down	hsa-let-7	Pancreatic Neoplasms	23338123	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors.
tissue_expression_down	hsa-let-7a-1	Pancreatic Neoplasms	21463919	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype
tissue_expression_down	hsa-let-7a-2	Pancreatic Neoplasms	21463919	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype
tissue_expression_down	hsa-let-7a-3	Pancreatic Neoplasms	21463919	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype
tissue_expression_down	hsa-let-7b	Pancreatic Neoplasms	21463919	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype
tissue_expression_down	hsa-let-7c	Pancreatic Neoplasms	21463919	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype
tissue_expression_down	hsa-let-7c	Pancreatic Neoplasms	22929886	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The expression of let-7c, let-7f, and miR-200c were significantly reduced in most patients whereas the expression of miR-486-5p and miR-451 were significantly elevated in all pancreas cancer patients.
tissue_expression_down	hsa-let-7f-1	Pancreatic Neoplasms	22929886	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The expression of let-7c, let-7f, and miR-200c were significantly reduced in most patients whereas the expression of miR-486-5p and miR-451 were significantly elevated in all pancreas cancer patients.
tissue_expression_down	hsa-let-7f-2	Pancreatic Neoplasms	22929886	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The expression of let-7c, let-7f, and miR-200c were significantly reduced in most patients whereas the expression of miR-486-5p and miR-451 were significantly elevated in all pancreas cancer patients.
tissue_expression_down	hsa-let-7i	Pancreatic Neoplasms	22820191	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Knockdown of Dicer 1 expression in BxPC-3 and Panc-1 cells resulted in significant increases in KRAS, p53, PTEN, and Dnmts protein levels and significant decreases in miR-22, miR-143, let-7i, and miR-29b expression.
tissue_expression_down	hsa-mir-100	Pancreatic Neoplasms	21953293	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Highly down-regulated in PDAC compared with normal ductal
tissue_expression_down	hsa-mir-107	Pancreatic Neoplasms	23338123	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors.
tissue_expression_down	hsa-mir-122	Pancreatic Neoplasms	22850622	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed.
tissue_expression_down	hsa-mir-125	Pancreatic Neoplasms	23338123	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors.
tissue_expression_down	hsa-mir-128	Pancreatic Neoplasms	23338123	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors.
tissue_expression_down	hsa-mir-130	Pancreatic Neoplasms	23338123	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors.
tissue_expression_down	hsa-mir-132	Pancreatic Neoplasms	23338123	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors.
tissue_expression_down	hsa-mir-133b	Pancreatic Neoplasms	19654291	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		downregulated, Up-regulation leads to the reversal of EMT
tissue_expression_down	hsa-mir-141	Pancreatic Neoplasms	24285464	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		hsa-mir-141 downregulates TM4SF1 to inhibit pancreatic cancer cell invasion and migration.
tissue_expression_down	hsa-mir-141	Pancreatic Neoplasms	23338123	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors.
tissue_expression_down	hsa-mir-143	Pancreatic Neoplasms	22905187	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-216a, -196a, -143 und -155) were detected at lower concentrations in feces of PCA patients when compared to controls (p<0.05).
tissue_expression_down	hsa-mir-143	Pancreatic Neoplasms	22820191	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Knockdown of Dicer 1 expression in BxPC-3 and Panc-1 cells resulted in significant increases in KRAS, p53, PTEN, and Dnmts protein levels and significant decreases in miR-22, miR-143, let-7i, and miR-29b expression.
tissue_expression_down	hsa-mir-145	Pancreatic Neoplasms	21953293	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Highly down-regulated in PDAC compared with normal ductal
tissue_expression_down	hsa-mir-145	Pancreatic Neoplasms	22850622	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed.
tissue_expression_down	hsa-mir-146a	Pancreatic Neoplasms	22850622	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed.
tissue_expression_down	hsa-mir-146a	Pancreatic Neoplasms	22213426	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model
tissue_expression_down	hsa-mir-148a	Pancreatic Neoplasms	21953293	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Highly down-regulated in PDAC compared with normal ductal
tissue_expression_down	hsa-mir-150	Pancreatic Neoplasms	24246865	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		MiR-150-5p is down-regulated in pancreatic cancer. Over-expression of miR-150-5p inhibits cell proliferation, blocked the cell cycle, but promotes cell apoptosis in pancreatic cancer cells
tissue_expression_down	hsa-mir-155	Pancreatic Neoplasms	22905187	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-216a, -196a, -143 und -155) were detected at lower concentrations in feces of PCA patients when compared to controls (p<0.05).
tissue_expression_down	hsa-mir-196a-1	Pancreatic Neoplasms	22905187	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-216a, -196a, -143 und -155) were detected at lower concentrations in feces of PCA patients when compared to controls (p<0.05).
tissue_expression_down	hsa-mir-196a-2	Pancreatic Neoplasms	22905187	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-216a, -196a, -143 und -155) were detected at lower concentrations in feces of PCA patients when compared to controls (p<0.05).
tissue_expression_down	hsa-mir-199b	Pancreatic Neoplasms	21953293	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-199b-5p: Highly down-regulated in PDAC compared with normal ductal
tissue_expression_down	hsa-mir-200b	Pancreatic Neoplasms	21463919	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype
tissue_expression_down	hsa-mir-200b	Pancreatic Neoplasms	22821831	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Furthermore, MIF-overexpression significantly increased ZEB1/2 and decreased miR-200b expression, while shRNA-mediated inhibition of MIF increased E-cadherin and miR-200b expression, and reduced the expression of ZEB1/2 in Panc1 cells.
tissue_expression_down	hsa-mir-200c	Pancreatic Neoplasms	21463919	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype
tissue_expression_down	hsa-mir-200c	Pancreatic Neoplasms	22929886	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The expression of let-7c, let-7f, and miR-200c were significantly reduced in most patients whereas the expression of miR-486-5p and miR-451 were significantly elevated in all pancreas cancer patients.
tissue_expression_down	hsa-mir-216a	Pancreatic Neoplasms	22905187	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-216a, -196a, -143 und -155) were detected at lower concentrations in feces of PCA patients when compared to controls (p<0.05).
tissue_expression_down	hsa-mir-216a	Pancreatic Neoplasms	23174591	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The down-regulated expression of miR-216a in pancreatic cancer suggests the involvement of miR-216a in the tumorigenesis and development of pancreatic cancer
tissue_expression_down	hsa-mir-216a	Pancreatic Neoplasms	22213426	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model
tissue_expression_down	hsa-mir-216b	Pancreatic Neoplasms	22213426	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model
tissue_expression_down	hsa-mir-217	Pancreatic Neoplasms	22213426	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model
tissue_expression_down	hsa-mir-218	Pancreatic Neoplasms	26662432	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Our findings suggested a significant downregulation in the expression of miR-218;this might have considerable potential value in the prognosis for pancreatic cancer.
tissue_expression_down	hsa-mir-22	Pancreatic Neoplasms	22820191	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Knockdown of Dicer 1 expression in BxPC-3 and Panc-1 cells resulted in significant increases in KRAS, p53, PTEN, and Dnmts protein levels and significant decreases in miR-22, miR-143, let-7i, and miR-29b expression.
tissue_expression_down	hsa-mir-223	Pancreatic Neoplasms	23834147	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Genistein down-regulates miR-223 expression in pancreatic cancer cells.
tissue_expression_down	hsa-mir-23a	Pancreatic Neoplasms	25422915	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		MiR-23a and/or miR-24 overexpression leads to gene silencing of FZD5, TMEM92 and/or HNF1B. Their downregulation induces deregulated expression and degradation of E-cadherin and β-catenin causing destabilisation of the cadherin/catenin complex, and altered the expression of Wnt-related genes. We propose a molecular (epi)genetic mechanism by which increased EMT-like cell shape transformation and integration into mesothelial monolayers of PDAC cells can be observed.
tissue_expression_down	hsa-mir-24	Pancreatic Neoplasms	25422915	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		MiR-23a and/or miR-24 overexpression leads to gene silencing of FZD5, TMEM92 and/or HNF1B. Their downregulation induces deregulated expression and degradation of E-cadherin and β-catenin causing destabilisation of the cadherin/catenin complex, and altered the expression of Wnt-related genes. We propose a molecular (epi)genetic mechanism by which increased EMT-like cell shape transformation and integration into mesothelial monolayers of PDAC cells can be observed.
tissue_expression_down	hsa-mir-27a	Pancreatic Neoplasms	25652374	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Grape seed proanthocyanidins extract inhibits pancreatic cancer cell growth through down-regulation of miR-27a expression.
tissue_expression_down	hsa-mir-27a	Pancreatic Neoplasms	23803693	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		in Panc1 cells metformin decreased microRNA-27a and induced the Sp repressor, ZBTB10, and disruption of miR-27a:ZBTB10 by metformin was phosphatase dependent.
tissue_expression_down	hsa-mir-29b	Pancreatic Neoplasms	22820191	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Knockdown of Dicer 1 expression in BxPC-3 and Panc-1 cells resulted in significant increases in KRAS, p53, PTEN, and Dnmts protein levels and significant decreases in miR-22, miR-143, let-7i, and miR-29b expression.
tissue_expression_down	hsa-mir-31	Pancreatic Neoplasms	22850622	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed.
tissue_expression_down	hsa-mir-34	Pancreatic Neoplasms	23338123	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors.
tissue_expression_down	hsa-mir-34a	Pancreatic Neoplasms	22114136	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		In the initial cohort of 48 PDAC (pancreatic ductal adenocarcinoma) patients, high expression of miR-21 (Hazard ratio (HR): 3.22, 95% Confidence Interval (CI):1.21-8.58) and reduced expression of miR-34a (HR 0.15, 95%CI: 0.06-0.37) and miR-30d (HR:0.30, 95%CI:0.12-0.79) were associated with poor overall survival following resection independent of clinical covariates. In a further validation set of 24 patients miR-21 and miR-34a expression again significantly correlated with overall survival (P = 0.031 and P = 0.001).
tissue_expression_down	hsa-mir-34a	Pancreatic Neoplasms	20037478	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Finally,restituted expression of miR-34a, a miRNA whose expression is frequently lost in PDAC cell lines, abrogates growth, demonstrating that the anti-proliferative activity of this miRNA is operative in PDAC.
tissue_expression_down	hsa-mir-451a	Pancreatic Neoplasms	21953293	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Highly down-regulated in PDAC compared with normal ductal
tissue_expression_down	hsa-mir-497	Pancreatic Neoplasms	25149530	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		MiR-497 downregulation contributes to the malignancy of pancreatic cancer and associates with a poor prognosis.
tissue_expression_down	hsa-mir-520h	Pancreatic Neoplasms	20628378	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-520h:miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion, and side populations
tissue_expression_down	hsa-mir-21	Parkinson Disease	27173998	nervous system disease	DOID:14330	G20	D010300	PS168600		GP significantly downregulated miR-21.
tissue_expression_down	hsa-mir-34b	Parkinson Disease	21558425	nervous system disease	DOID:14330	G20	D010300	PS168600		This miRNA was downregulated in brain areas with variable neuropathological affectation at clinical (motor) stages (Braak stages 4 and 5) of the disease,including the amygdala, frontal cortex, substantia nigra and cerebellum. This miRNA modulate mitochondrial function.
tissue_expression_down	hsa-mir-34b	Parkinson Disease	22245218	nervous system disease	DOID:14330	G20	D010300	PS168600		miR-133b is deficient in the PD midbrain as well as in mouse models, and miR-34b/34c are decreased in several affected brain regions in PD and incidental Lewy body disease.
tissue_expression_down	hsa-mir-34c	Parkinson Disease	21558425	nervous system disease	DOID:14330	G20	D010300	PS168600		This miRNA was downregulated in brain areas with variable neuropathological affectation at clinical (motor) stages (Braak stages 4 and 5) of the disease,including the amygdala, frontal cortex, substantia nigra and cerebellum. This miRNA modulate mitochondrial function.
tissue_expression_down	hsa-mir-34c	Parkinson Disease	22245218	nervous system disease	DOID:14330	G20	D010300	PS168600		miR-133b is deficient in the PD midbrain as well as in mouse models, and miR-34b/34c are decreased in several affected brain regions in PD and incidental Lewy body disease.
tissue_expression_down	hsa-mir-132	Periodontal Diseases	26481834	gastrointestinal system disease	DOID:3388	K05.6	D010510		HP:0000704	Furthermore, miRNA-132 and miRNA-146a were significantly decreased in the pancreas of infected rats.
tissue_expression_down	hsa-mir-146a	Periodontal Diseases	26481834	gastrointestinal system disease	DOID:3388	K05.6	D010510		HP:0000704	Furthermore, miRNA-132 and miRNA-146a were significantly decreased in the pancreas of infected rats.
tissue_expression_down	hsa-mir-495	Periodontitis	26987780	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Seven randomly selected up-regulated (miR-21-5p, 498, 548a-5p) and down-regulated (miR-495-3p, 539-5p, 34c-3p and 7a-2-3p) miRNAs were examined by qRT-PCR, and the results proved the accuracy of the miRNA
tissue_expression_down	hsa-mir-130b	Pituitary Adenoma	24681352	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	Mir-23b and miR-130b expression is downregulated in pituitary adenomas.
tissue_expression_down	hsa-mir-23b	Pituitary Adenoma	24681352	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	Mir-23b and miR-130b expression is downregulated in pituitary adenomas.
tissue_expression_down	hsa-mir-1	Pituitary Neoplasms	28577032	disease of cellular proliferation	DOID:1785	C75.1	D010911		HP:0040277	Studies have shown that the levels of miR-1, miR-195, and miR-206 are downregulated in Pas
tissue_expression_down	hsa-mir-195	Pituitary Neoplasms	28577032	disease of cellular proliferation	DOID:1785	C75.1	D010911		HP:0040277	Studies have shown that the levels of miR-1, miR-195, and miR-206 are downregulated in Pas
tissue_expression_down	hsa-mir-206	Pituitary Neoplasms	28577032	disease of cellular proliferation	DOID:1785	C75.1	D010911		HP:0040277	Studies have shown that the levels of miR-1, miR-195, and miR-206 are downregulated in Pas
tissue_expression_down	hsa-mir-16	Pleural Mesothelioma	24148817	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	The miR-15/16 family is downregulated and has tumour suppressor function in MPM. Restoring miR-16 expression represents a novel therapeutic approach for MPM.
tissue_expression_down	hsa-mir-592	Polycystic Ovarian Syndrome	26679164	syndrome	DOID:11612	E28.2	D011085	184700		miRNA-592 is downregulated and may target LHCGR in polycystic ovary syndrome patients.
tissue_expression_down	hsa-mir-92b	Polycystic Ovarian Syndrome	25591557	syndrome	DOID:11612	E28.2	D011085	184700		two (miR-92a and miR-92b)  of them were significantly downregulated in PCOS women
tissue_expression_down	hsa-mir-150	Polycythemia Vera	20218812	hematopoietic system disease	DOID:8997	D45	D011087	263300		We observed that miR-451 up-regulation and miR-150 down-regulation are associated with progression of erythroid maturation in K562 cells.
tissue_expression_down	hsa-mir-125b	Preeclampsia	27412941	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Compared with 0 渭mol/L H2O2 group, miR-125b-5p significantly decreased in 100 渭mol/L H2O2 group, while Smad4 protein significantly increased.
tissue_expression_down	hsa-mir-126	Preeclampsia	25341970	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	miR-126 was downregulated in placentas from patients with pre-eclampsia and this correlated with decreased VEGF expression. These findings indicate that miRNA-126 may be involved in pre-eclampsia pathogenesis and could be a potential biomarker for this disease.
tissue_expression_down	hsa-mir-20a	Preeclampsia	26992682	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	The expression level of miR-200c,-20a and -20b as well as the level of CBS, CSE and VEGF were downregulated in preeclamptic placentas.
tissue_expression_down	hsa-mir-325	Preeclampsia	22710575	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	The expression of hsa-miR-325 was downregulated in the case of PE. Changes in hsa-miR-325 expression in the case of pregnancy-related hypertensive disorders might affect the oxidative stress pathways and heat-shock protein production.
tissue_expression_down	hsa-mir-411	Preeclampsia	24664294	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	In this study, a total of 9 downregulated miRNAs (miR-195, miR-223, miR-218, miR-17, miR-18a, miR-19b1, miR-92a1, miR-379, and miR-411) and 7 upregulated miRNAs (miR-210, miR-30a-3p, miR-518b, miR-524, miR-17-3p, miR-151, and miR-193b) were identified in severe preeclampsia (sPE) placentas when compared with normal pregnant controls.
tissue_expression_down	hsa-let-7b	Primary Biliary Cirrhosis	24074714	immune system disease	DOID:12236	K74.5	D008105	PS109720	HP:0002613	Decreased expression of miR-let-7b may be associated with development and progression of PBC, and this miRNA may represent a novel target of improved diagnostic and preventive strategies for PBC.
tissue_expression_down	hsa-mir-122a	Primary Biliary Cirrhosis	19345069	immune system disease	DOID:12236	K74.5	D008105	PS109720	HP:0002613	A total of 35 independent miRNAs were found to be differentially expressed in PBC (p < 0.001).Quantitative PCR was employed to validate down-regulation of microRNA-122a (miR-122a) and miR-26a and the increased expression of miR-328 and miR-299-5p.
tissue_expression_down	hsa-mir-26a	Primary Biliary Cirrhosis	19345069	immune system disease	DOID:12236	K74.5	D008105	PS109720	HP:0002613	A total of 35 independent miRNAs were found to be differentially expressed in PBC (p < 0.001).Quantitative PCR was employed to validate down-regulation of microRNA-122a (miR-122a) and miR-26a and the increased expression of miR-328 and miR-299-5p.
tissue_expression_down	hsa-mir-146	Prion Diseases	22965126	nervous system disease	DOID:649	A81.9	D017096			we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes.
tissue_expression_down	hsa-mir-125b-1	Prolactinoma	22490835	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	down-regulated
tissue_expression_down	hsa-mir-125b-2	Prolactinoma	22490835	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	down-regulated
tissue_expression_down	hsa-mir-130a	Prolactinoma	22490835	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	down-regulated
tissue_expression_down	hsa-mir-199b	Prolactinoma	22490835	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	miR-199b-3p: down-regulated
tissue_expression_down	hsa-mir-200b	Prolactinoma	22490835	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	down-regulated
tissue_expression_down	hsa-let-7	Prostate Neoplasms	27197175	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	In cancer cells, reduced expression of ESE3/EHF upregulated  Lin28A and Lin28B and downregulated the let-7 microRNAs.
tissue_expression_down	hsa-let-7c	Prostate Neoplasms	21880514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	significantly changed during the progression of cancer
tissue_expression_down	hsa-mir-100	Prostate Neoplasms	21880514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	significantly changed during the progression of cancer
tissue_expression_down	hsa-mir-100	Prostate Neoplasms	22999546	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-100 and miR-10a showed under expression and over expression, respectively, in low grade pTa tumors.
tissue_expression_down	hsa-mir-106a	Prostate Neoplasms	22719071	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	downregulated in prostate cancer stem/progenitor cell.
tissue_expression_down	hsa-mir-106a	Prostate Neoplasms	21714127	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors
tissue_expression_down	hsa-mir-106b	Prostate Neoplasms	20878953	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Down-regulation of microRNA 106b is involved in p21-mediated cell cycle arrest in response to radiation in prostate cancer cells.
tissue_expression_down	hsa-mir-106b	Prostate Neoplasms	21714127	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors
tissue_expression_down	hsa-mir-126	Prostate Neoplasms	25277191	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Osteoblast-derived WNT-induced secreted protein 1 increases VCAM-1 expression and enhances prostate cancer metastasis by down-regulating miR-126.
tissue_expression_down	hsa-mir-130a	Prostate Neoplasms	22391564	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma.
tissue_expression_down	hsa-mir-130b	Prostate Neoplasms	25154741	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	MiR-130b suppresses prostate cancer metastasis through down-regulation of MMP2.
tissue_expression_down	hsa-mir-133b	Prostate Neoplasms	19946373	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	downregulated
tissue_expression_down	hsa-mir-133b	Prostate Neoplasms	22532850	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Expression of miR-133b in tumor specimens of prostate cancer patients was significantly downregulated in 75% of the cases, when compared with matched healthy tissue.
tissue_expression_down	hsa-mir-135b	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b,  miR-146a and miR-491.
tissue_expression_down	hsa-mir-141	Prostate Neoplasms	22719071	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	downregulated in prostate cancer stem/progenitor cell.
tissue_expression_down	hsa-mir-143	Prostate Neoplasms	21880514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	significantly changed during the progression of cancer
tissue_expression_down	hsa-mir-143	Prostate Neoplasms	19671871	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Although miR-143 and miR-145 are highly expressed in normal tissues, they are significantly down-regulated in prostate cancer cells. 
tissue_expression_down	hsa-mir-145	Prostate Neoplasms	17028596	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	mir-145 downregulated in breast cancer (Iorio et al., 2005) and lung cancer and deleted in prostate cancer (Yanaihara et al., 2006);
tissue_expression_down	hsa-mir-145	Prostate Neoplasms	18949015	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-145: down-regulated
tissue_expression_down	hsa-mir-145	Prostate Neoplasms	21880514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	significantly changed during the progression of cancer
tissue_expression_down	hsa-mir-145	Prostate Neoplasms	19671871	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Although miR-143 and miR-145 are highly expressed in normal tissues, they are significantly down-regulated in prostate cancer cells. 
tissue_expression_down	hsa-mir-146a	Prostate Neoplasms	21880514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	significantly changed during the progression of cancer
tissue_expression_down	hsa-mir-146a	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b,  miR-146a and miR-492.
tissue_expression_down	hsa-mir-15a	Prostate Neoplasms	21532615	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-15 and miR-16 are downregulated in fibroblasts surrounding the prostate tumors of the majority of 23 patients analyzed.
tissue_expression_down	hsa-mir-15a	Prostate Neoplasms	21880514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	significantly changed during the progression of cancer
tissue_expression_down	hsa-mir-15a	Prostate Neoplasms	27322147	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-15a and miR-186, associated with expression of VEGF and hypoxia inducible factor-1伪 (HIF-1伪), were down-regulated in mPGES-1+/+ cells.
tissue_expression_down	hsa-mir-15b	Prostate Neoplasms	21532615	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-15 and miR-16 are downregulated in fibroblasts surrounding the prostate tumors of the majority of 23 patients analyzed.
tissue_expression_down	hsa-mir-16-1	Prostate Neoplasms	19738602	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	microRNA (miR)-16, which is expressed at lower levels in prostate cancer cells, affects the proliferation of human prostate cancer cell lines both in vitro and in vivo
tissue_expression_down	hsa-mir-16-1	Prostate Neoplasms	21532615	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-15 and miR-16 are downregulated in fibroblasts surrounding the prostate tumors of the majority of 23 patients analyzed.
tissue_expression_down	hsa-mir-16-1	Prostate Neoplasms	21880514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	significantly changed during the progression of cancer
tissue_expression_down	hsa-mir-16-2	Prostate Neoplasms	19738602	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	microRNA (miR)-16, which is expressed at lower levels in prostate cancer cells, affects the proliferation of human prostate cancer cell lines both in vitro and in vivo
tissue_expression_down	hsa-mir-16-2	Prostate Neoplasms	21532615	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-15 and miR-16 are downregulated in fibroblasts surrounding the prostate tumors of the majority of 23 patients analyzed.
tissue_expression_down	hsa-mir-16-2	Prostate Neoplasms	21880514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	significantly changed during the progression of cancer
tissue_expression_down	hsa-mir-17	Prostate Neoplasms	21592394	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated.
tissue_expression_down	hsa-mir-17	Prostate Neoplasms	21714127	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors
tissue_expression_down	hsa-mir-18	Prostate Neoplasms	21592394	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated.
tissue_expression_down	hsa-mir-18	Prostate Neoplasms	21714127	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors
tissue_expression_down	hsa-mir-191	Prostate Neoplasms	21880514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	significantly changed during the progression of cancer
tissue_expression_down	hsa-mir-199a-1	Prostate Neoplasms	21880514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	significantly changed during the progression of cancer
tissue_expression_down	hsa-mir-199a-2	Prostate Neoplasms	21880514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	significantly changed during the progression of cancer
tissue_expression_down	hsa-mir-19a	Prostate Neoplasms	21592394	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated.
tissue_expression_down	hsa-mir-19a	Prostate Neoplasms	21714127	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors
tissue_expression_down	hsa-mir-19b-1	Prostate Neoplasms	21592394	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated.
tissue_expression_down	hsa-mir-19b-1	Prostate Neoplasms	21714127	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors
tissue_expression_down	hsa-mir-203	Prostate Neoplasms	22391564	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma.
tissue_expression_down	hsa-mir-205	Prostate Neoplasms	23974361	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-205 is frequently downregulated in prostate cancer and acts as a tumor suppressor by inhibiting tumor growth.
tissue_expression_down	hsa-mir-205	Prostate Neoplasms	24173237	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	MiR-205 is progressively down-regulated in lymph node metastasis but fails as a prognostic biomarker in high-risk prostate cancer.
tissue_expression_down	hsa-mir-205	Prostate Neoplasms	22391564	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma.
tissue_expression_down	hsa-mir-20a	Prostate Neoplasms	21592394	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated.
tissue_expression_down	hsa-mir-20a	Prostate Neoplasms	21714127	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors
tissue_expression_down	hsa-mir-21	Prostate Neoplasms	25216674	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Our results indicate that miR-21 is able to downregulate p57(Kip2) expression by targeting the coding region of the gene and is also able to attenuate p57(Kip2) mediated functional responses. This is the first report demonstrating that p57(Kip2) is a novel target of miR-21 in prostate cancer and revealing a novel oncogenic function of this microRNA.
tissue_expression_down	hsa-mir-21	Prostate Neoplasms	21177307	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	We also observed a significant down-regulation of androgen-regulated miRNA-21 and up-regulation of a tumor suppressor, miRNA-330, in tumors of mice treated with EGCG
tissue_expression_down	hsa-mir-21	Prostate Neoplasms	21594291	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	In addition, anti-invasive microRNAs such as miR-335, miR-205, miR-200, and miR-126, were up-regulated, whereas pro-invasive microRNA such as miR-21 and miR-373, were down-regulated.
tissue_expression_down	hsa-mir-218-1	Prostate Neoplasms	21880514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	significantly changed during the progression of cancer
tissue_expression_down	hsa-mir-22	Prostate Neoplasms	22815235	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	We previously detected several miRNAs, for example, miR-24 and miR-22, as significantly downregulated in Pca
tissue_expression_down	hsa-mir-221	Prostate Neoplasms	18949015	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-221: down-regulated
tissue_expression_down	hsa-mir-221	Prostate Neoplasms	19585579	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-221:Expression of microRNA-221 is progressively reduced in aggressive prostate cancer and metastasis
tissue_expression_down	hsa-mir-221	Prostate Neoplasms	21378318	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-221 Is Down-regulated in TMPRSS2:ERG Fusion-positive Prostate Cancer.
tissue_expression_down	hsa-mir-221	Prostate Neoplasms	22127852	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The altered expression of MiR-221/-222 (increased miR-221/-222 expression ) and MiR-23b/-27b (down-regulated ) is associated with the development of human castration resistant prostate cancer.
tissue_expression_down	hsa-mir-221	Prostate Neoplasms	28886115	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Androgen receptor-mediated downregulation of microRNA-221 and -222 in castration-resistant prostate cancer.
tissue_expression_down	hsa-mir-222	Prostate Neoplasms	18949015	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-222: down-regulated
tissue_expression_down	hsa-mir-222	Prostate Neoplasms	21378318	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-221 Is Down-regulated in TMPRSS2:ERG Fusion-positive Prostate Cancer.
tissue_expression_down	hsa-mir-222	Prostate Neoplasms	22127852	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The altered expression of MiR-221/-222 (increased miR-221/-222 expression ) and MiR-23b/-27b (down-regulated ) is associated with the development of human castration resistant prostate cancer.
tissue_expression_down	hsa-mir-222	Prostate Neoplasms	28886115	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Androgen receptor-mediated downregulation of microRNA-221 and -222 in castration-resistant prostate cancer.
tissue_expression_down	hsa-mir-222	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b,  miR-146a and miR-491.
tissue_expression_down	hsa-mir-224	Prostate Neoplasms	23136246	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Downregulation and Prognostic Performance of MicroRNA 224 Expression in Prostate Cancer
tissue_expression_down	hsa-mir-23b	Prostate Neoplasms	18949015	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-23b: down-regulated
tissue_expression_down	hsa-mir-23b	Prostate Neoplasms	22127852	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The altered expression of MiR-221/-222 (increased miR-221/-222 expression ) and MiR-23b/-27b (down-regulated ) is associated with the development of human castration resistant prostate cancer.
tissue_expression_down	hsa-mir-24	Prostate Neoplasms	22815235	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	We previously detected several miRNAs, for example, miR-24 and miR-22, as significantly downregulated in Pca
tissue_expression_down	hsa-mir-25	Prostate Neoplasms	21880514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	significantly changed during the progression of cancer
tissue_expression_down	hsa-mir-27a	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b,  miR-146a and miR-491.
tissue_expression_down	hsa-mir-27b	Prostate Neoplasms	22127852	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The altered expression of MiR-221/-222 (increased miR-221/-222 expression ) and MiR-23b/-27b (down-regulated ) is associated with the development of human castration resistant prostate cancer.
tissue_expression_down	hsa-mir-32	Prostate Neoplasms	21880514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	significantly changed during the progression of cancer
tissue_expression_down	hsa-mir-324	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b,  miR-146a and miR-491.
tissue_expression_down	hsa-mir-345	Prostate Neoplasms	26227059	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Taken together, our data suggest that miR-345 exerts a suppressive effect on prostate cancer proliferation, invasion and migration through downregulation of Smad1.
tissue_expression_down	hsa-mir-34a	Prostate Neoplasms	23936419	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Our results indicated that genistein inhibited PCa cell growth through down-regulation of oncogenic HOTAIR that is also targeted by tumor suppressor miR-34a. These findings enhance understanding of how genistein regulates lncRNA HOTAIR and miR-34a in PCa.
tissue_expression_down	hsa-mir-34a	Prostate Neoplasms	22719071	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	downregulated in prostate cancer stem/progenitor cell.
tissue_expression_down	hsa-mir-34c	Prostate Neoplasms	20162671	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-34c is down regulated in prostate cancer and exerts tumor suppressive functions
tissue_expression_down	hsa-mir-34c	Prostate Neoplasms	21351256	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-34c is downregulated in prostate cancer and exerts tumor suppressive functions.
tissue_expression_down	hsa-mir-373	Prostate Neoplasms	19158933	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-373: MicroRNAs 373 and 520c Are Downregulated in Prostate Cancer, Suppress CD44
tissue_expression_down	hsa-mir-373	Prostate Neoplasms	21594291	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	In addition, anti-invasive microRNAs such as miR-335, miR-205, miR-200, and miR-126, were up-regulated, whereas pro-invasive microRNA such as miR-21 and miR-373, were down-regulated.
tissue_expression_down	hsa-mir-486	Prostate Neoplasms	19946373	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-486-5p: downregulated
tissue_expression_down	hsa-mir-486	Prostate Neoplasms	25597612	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miRNAs (miR-125b-5p, miR-126-5p, miR-151a-5p, miR-221-3p, and miR-222-3p) were significantly upregulated with downregulation of miR-486-5p.
tissue_expression_down	hsa-mir-491	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b,  miR-146a and miR-492.
tissue_expression_down	hsa-mir-502	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b,  miR-146a and miR-491.
tissue_expression_down	hsa-mir-520c	Prostate Neoplasms	19158933	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-520c: MicroRNAs 373 and 520c Are Downregulated in Prostate Cancer, Suppress CD44
tissue_expression_down	hsa-mir-521	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b,  miR-146a and miR-491.
tissue_expression_down	hsa-mir-579	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b,  miR-146a and miR-491.
tissue_expression_down	hsa-mir-92-1	Prostate Neoplasms	21592394	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated.
tissue_expression_down	hsa-mir-92-1	Prostate Neoplasms	21714127	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors
tissue_expression_down	hsa-mir-92a-1	Prostate Neoplasms	22412975	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Isoflavone and BR-DIM down-regulated the expression of miR-92a, which is known to be associated with RANKL signaling, EMT and cancer progression.
tissue_expression_down	hsa-mir-92a-2	Prostate Neoplasms	22412975	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Isoflavone and BR-DIM down-regulated the expression of miR-92a, which is known to be associated with RANKL signaling, EMT and cancer progression.
tissue_expression_down	hsa-mir-125b	Psoriasis	27729619	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	upregulation of miR-31/miR-203 and downregulation of hsa-miR-99a/miR-125b work together in concert to facilitate the development of psoriasis pathogenesis
tissue_expression_down	hsa-mir-125b-1	Psoriasis	17622355	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	The level of this miRNA significantly (p<0.001 for both) decreased both in psoriasis and atopic eczema.
tissue_expression_down	hsa-mir-125b-2	Psoriasis	17622355	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	The level of this miRNA significantly (p<0.001 for both) decreased both in psoriasis and atopic eczema.
tissue_expression_down	hsa-mir-21	Psoriasis	21373745	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	Real-time PCR and immunohistochemistry showed that p63 expression was not significantly affected, whereas NB-UVB phototherapy significantly decreased expression ofmiR-21 (p = 0.003) and increased miR-125b levels (p = 0.003). The results indicate that the unresolved p63 abnormality in treated epidermis may play a role in maintenance of this disease.
tissue_expression_down	hsa-mir-217	Psoriasis	26826389	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	MiR-217 is down-regulated in psoriasis and promotes keratinocyte differentiation via targeting GRHL2.
tissue_expression_down	hsa-mir-99a	Psoriasis	27729619	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	upregulation of miR-31/miR-203 and downregulation of hsa-miR-99a/miR-125b work together in concert to facilitate the development of psoriasis pathogenesis
tissue_expression_down	hsa-mir-1246	Pulmonary Hypertension	23717609	cardiovascular system disease	DOID:6432	I27.20	D006976	PS178600	HP:0002092	We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects.
tissue_expression_down	hsa-mir-204	Pulmonary Hypertension	23114789	cardiovascular system disease	DOID:6432	I27.20	D006976	PS178600	HP:0002092	MEX suppressed the hypoxic activation of signal transducer and activator of transcription 3 (STAT3) and the upregulation of the miR-17 superfamily of microRNA clusters, whereas it increased lung levels of miR-204, a key microRNA, the expression of which is decreased in human pulmonary hypertension.
tissue_expression_down	hsa-mir-451	Pulmonary Hypertension	23717609	cardiovascular system disease	DOID:6432	I27.20	D006976	PS178600	HP:0002092	We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects.
tissue_expression_down	hsa-mir-720	Rectal Neoplasms	22172905	disease of cellular proliferation	DOID:1984		D012004			Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases.
tissue_expression_down	hsa-mir-125a	Respiratory Syncytial Virus Pneumonia	25884957	disease by infectious agent	DOID:1273	J12.1	D018357			microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-κB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV.
tissue_expression_down	hsa-mir-125b	Respiratory Syncytial Virus Pneumonia	25884957	disease by infectious agent	DOID:1273	J12.1	D018357			microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-κB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV.
tissue_expression_down	hsa-mir-429	Respiratory Syncytial Virus Pneumonia	25884957	disease by infectious agent	DOID:1273	J12.1	D018357			microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-κB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV.
tissue_expression_down	hsa-mir-106a	Retinal Neovascularization	18500251			H35.059	D015861		HP:0030666	decreased
tissue_expression_down	hsa-mir-214	Retinal Neovascularization	18500251			H35.059	D015861		HP:0030666	decreased
tissue_expression_down	hsa-mir-424	Retinal Neovascularization	18500251			H35.059	D015861		HP:0030666	decreased
tissue_expression_down	hsa-mir-1	Retinitis Pigmentosa	18034880	nervous system disease	DOID:10584	H35.52	D012174	PS268000	HP:0000510	Expression of miR-1 and miR-133 decreased by more than 2.5-fold (P < 0.001), whereas expression of miR-96 and miR-183 increased by more than 3-fold (P < 0.001) in Pro347Ser retinas, as validated by qPCR.
tissue_expression_down	hsa-mir-133	Retinitis Pigmentosa	18034880	nervous system disease	DOID:10584	H35.52	D012174	PS268000	HP:0000510	Expression of miR-1 and miR-133 decreased by more than 2.5-fold (P < 0.001), whereas expression of miR-96 and miR-183 increased by more than 3-fold (P < 0.001) in Pro347Ser retinas, as validated by qPCR.
tissue_expression_down	hsa-mir-17	Retinoblastoma	25359779	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	STAT3 inhibition suppresses proliferation of retinoblastoma through down-regulation of positive feedback loop of STAT3/miR-17-92 clusters.
tissue_expression_down	hsa-mir-18	Retinoblastoma	25359779	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	STAT3 inhibition suppresses proliferation of retinoblastoma through down-regulation of positive feedback loop of STAT3/miR-17-92 clusters.
tissue_expression_down	hsa-mir-19a	Retinoblastoma	25359779	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	STAT3 inhibition suppresses proliferation of retinoblastoma through down-regulation of positive feedback loop of STAT3/miR-17-92 clusters.
tissue_expression_down	hsa-mir-19b-1	Retinoblastoma	25359779	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	STAT3 inhibition suppresses proliferation of retinoblastoma through down-regulation of positive feedback loop of STAT3/miR-17-92 clusters.
tissue_expression_down	hsa-mir-204	Retinoblastoma	25647033	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	MiR-204, down-regulated in retinoblastoma, regulates proliferation and invasion of human retinoblastoma cells by targeting CyclinD2 and MMP-9.
tissue_expression_down	hsa-mir-20a	Retinoblastoma	25359779	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	STAT3 inhibition suppresses proliferation of retinoblastoma through down-regulation of positive feedback loop of STAT3/miR-17-92 clusters.
tissue_expression_down	hsa-mir-433	Retinoblastoma	27470361	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	We found that the expression levels of miR-433 were downregulated in RB  tissues.
tissue_expression_down	hsa-mir-513a-1	Retinoblastoma	22886978	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	miR-513a-5p expression was decreased in Rb cells after etoposide treatment.
tissue_expression_down	hsa-mir-513a-2	Retinoblastoma	22886978	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	miR-513a-5p expression was decreased in Rb cells after etoposide treatment.
tissue_expression_down	hsa-mir-513b	Retinoblastoma	22886978	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	miR-513a-5p expression was decreased in Rb cells after etoposide treatment.
tissue_expression_down	hsa-mir-513c	Retinoblastoma	22886978	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	miR-513a-5p expression was decreased in Rb cells after etoposide treatment.
tissue_expression_down	hsa-mir-92-1	Retinoblastoma	25359779	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	STAT3 inhibition suppresses proliferation of retinoblastoma through down-regulation of positive feedback loop of STAT3/miR-17-92 clusters.
tissue_expression_down	hsa-let-7a-1	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	let-7a: down-regulated
tissue_expression_down	hsa-let-7a-2	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	let-7a: down-regulated
tissue_expression_down	hsa-let-7a-3	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	let-7a: down-regulated
tissue_expression_down	hsa-mir-144	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-144: down-regulated
tissue_expression_down	hsa-mir-20b	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-20b: down-regulated
tissue_expression_down	hsa-mir-375	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-375: down-regulated
tissue_expression_down	hsa-mir-206	Sarcoma [unspecific]	26878133	disease of cellular proliferation	DOID:1115	C49	D012509		HP:0100242	miR-133, miR-1, and miR-206 was significantly underexpressed in well-differentiated liposarcoma and synovial sarcoma
tissue_expression_down	hsa-mir-132	Schizophrenia	22315408	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	MicroRNA-132 downregulation in schizophrenia has implications for both neurodevelopment and adult brain function.
tissue_expression_down	hsa-mir-195	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-20b	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-212	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-24-1	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-24-2	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-26b	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-29a	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-29b-1	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-29c	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-30a	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-30b	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-30d	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-30e	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-7-1	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-7-2	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-7-3	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-9-1	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-9-2	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-92a-1	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-92a-2	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-92b	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-9-3	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	downregulation
tissue_expression_down	hsa-mir-129-1	Scleroderma, Systemic	22403442	musculoskeletal system disease	DOID:418	M34	D012595	181750		IL-17A signaling, not IL-17F, has an antifibrogenic effect via the upregulation of miR-129-5p and the downregulation of connective tissue growth factor and ж┿(I) collagen.
tissue_expression_down	hsa-mir-129-2	Scleroderma, Systemic	22403442	musculoskeletal system disease	DOID:418	M34	D012595	181750		IL-17A signaling, not IL-17F, has an antifibrogenic effect via the upregulation of miR-129-5p and the downregulation of connective tissue growth factor and ж┿(I) collagen.
tissue_expression_down	hsa-mir-124-1	Sepsis	22846781			A41.9	D018805		HP:0100806	Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-alpha
tissue_expression_down	hsa-mir-124-2	Sepsis	22846781			A41.9	D018805		HP:0100806	Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-alpha
tissue_expression_down	hsa-mir-299	Sjogren Syndrome	26888739	immune system disease	DOID:12894	M35.00	D012859	270150		downregulation of miR-1207-5p and miR-4695-3p expression was further revealed in the minor salivary glands of primary SS (pSS) patients.
tissue_expression_down	hsa-mir-208b	Spinal Cord Injuries	26603456			S34.139A	D013119			A progressive decline in skeletal muscle microRNA-208b and microRNA-499-5p expression occurred in humans during the first year after spinal cord injury
tissue_expression_down	hsa-mir-21	Spinal Cord Injuries	20816819			S34.139A	D013119			spinal cord injury (SCI)results in increased expression of miR Let-7a and miR16 while exercise leads to elevated levels of miR21 and decreased levels of miR15b. These changes in miR expression are correlated with changes in expression of their target genes: pro-apoptotic (decreased PTEN, PDCD4, and RAS mRNA) and anti-apoptotic (increased Bcl-2 mRNA) target genes. This is accompanied by a down-regulation of mRNA for caspase-7 and caspase-9 and reduced levels of caspase-7 protein.
tissue_expression_down	hsa-mir-9	Spinal Muscular Atrophy	24751385	nervous system disease	DOID:12377	G12.9	D009134	253300	HP:0007269	Survival of motor neuron protein downregulates miR-9 expression in patients with  spinal muscular atrophy.
tissue_expression_down	hsa-mir-221	Spinal Stenosis	26571175	musculoskeletal system disease	DOID:6725	M48.0	D013130		HP:0005733	miR-221 was significantly lower in LF tissues of patients than controls.
tissue_expression_down	hsa-mir-142	Squamous Cell Carcinoma	20652977	disease of cellular proliferation	DOID:1749		D002294			The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes.
tissue_expression_down	hsa-mir-155	Squamous Cell Carcinoma	20652977	disease of cellular proliferation	DOID:1749		D002294			The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes.
tissue_expression_down	hsa-mir-181a	Squamous Cell Carcinoma	20652977	disease of cellular proliferation	DOID:1749		D002294			The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes.
tissue_expression_down	hsa-mir-181b	Squamous Cell Carcinoma	20652977	disease of cellular proliferation	DOID:1749		D002294			The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes.
tissue_expression_down	hsa-mir-203	Squamous Cell Carcinoma	19789312	disease of cellular proliferation	DOID:1749		D002294			In adenocarcinoma patients, miR-21, miR-223, miR-192, and miR-194 expression was elevated, whereas miR-203 expression was reduced in cancerous compared with noncancerous tissue.
tissue_expression_down	hsa-mir-218	Squamous Cell Carcinoma	20652977	disease of cellular proliferation	DOID:1749		D002294			The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes.
tissue_expression_down	hsa-mir-221	Squamous Cell Carcinoma	20652977	disease of cellular proliferation	DOID:1749		D002294			The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes.
tissue_expression_down	hsa-mir-222	Squamous Cell Carcinoma	20652977	disease of cellular proliferation	DOID:1749		D002294			The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes.
tissue_expression_down	hsa-mir-29a	Squamous Cell Carcinoma	20652977	disease of cellular proliferation	DOID:1749		D002294			The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes.
tissue_expression_down	hsa-mir-143	Squamous Cell Carcinoma, Cerevial	24774218	endocrine system disease	DOID:5531					Down-regulated miR-143 is related with tumor size, lymph node metastasis and HPV16 infection in cervical SCC, but miR-143 does not participate in the Taxol sensitivity response.
tissue_expression_down	hsa-mir-100	Squamous Cell Carcinoma, Esophageal	25218280	disease of cellular proliferation	DOID:3748		C562729			These findings show the reduced expression of miR-100 in human ESCC tissues and suggest a crucial role of its downregulation in ESCC progression and prognosis. More interestingly, the detection of miR-100 expression may be used to efficiently screen those ESCC patients who would benefit from radiotherapy.
tissue_expression_down	hsa-mir-106a	Squamous Cell Carcinoma, Esophageal	24314216	disease of cellular proliferation	DOID:3748		C562729			In esophageal squamous cell carcinomas, the miRNA-106a gene is under-expressed, with tumor suppressor function, and may be regarded as a biological marker to assess the prognosis in patients with esophageal squamous cell carcinoma.
tissue_expression_down	hsa-mir-10a	Squamous Cell Carcinoma, Esophageal	22966337	disease of cellular proliferation	DOID:3748		C562729			Down-regulation of microRNA 10a expression in esophageal squamous cell carcinoma cells.
tissue_expression_down	hsa-mir-133a	Squamous Cell Carcinoma, Esophageal	25280517	disease of cellular proliferation	DOID:3748		C562729			Combined downregulation of microRNA-133a and microRNA-133b predicts chemosensitivity of patients with esophageal squamous cell carcinoma undergoing paclitaxel-based chemotherapy.
tissue_expression_down	hsa-mir-133a	Squamous Cell Carcinoma, Esophageal	27735040	disease of cellular proliferation	DOID:3748		C562729			Low miR-133a expression is a predictor of outcome in patients with esophageal squamous cell cancer.
tissue_expression_down	hsa-mir-133b	Squamous Cell Carcinoma, Esophageal	25280517	disease of cellular proliferation	DOID:3748		C562729			Combined downregulation of microRNA-133a and microRNA-133b predicts chemosensitivity of patients with esophageal squamous cell carcinoma undergoing paclitaxel-based chemotherapy.
tissue_expression_down	hsa-mir-138	Squamous Cell Carcinoma, Esophageal	28759955	disease of cellular proliferation	DOID:3748		C562729			Downregulation of miR-138 predicts poor prognosis in patients with esophageal squamous cell carcinoma
tissue_expression_down	hsa-mir-145	Squamous Cell Carcinoma, Esophageal	25773691	disease of cellular proliferation	DOID:3748		C562729			Our data revealed a significant down-regulation of miR-145 in ESCC tissue samples. Based on our ROC curve analysis data (AUC = 0.74, p < 0.001) miR-145 could be regarded as a potential tumor marker for diagnosis of esophageal cancer.
tissue_expression_down	hsa-mir-302b	Squamous Cell Carcinoma, Esophageal	25773691	disease of cellular proliferation	DOID:3748		C562729			Our data revealed a significant down-regulation of miR-145 in ESCC tissue samples. Based on our ROC curve analysis data (AUC = 0.74, p < 0.001) miR-145 could be regarded as a potential tumor marker for diagnosis of esophageal cancer.
tissue_expression_down	hsa-mir-494	Squamous Cell Carcinoma, Esophageal	25480402	disease of cellular proliferation	DOID:3748		C562729			The qRT-PCR assays showed significant downregulation of miR-494 (P <0.05) and upregulation of CLPTM1L mRNA (P < 0.05), both of which were significantly associated with lymph node metastases (P < 0.05). High expression of miR-494 inhibited cell proliferation and invasion and promoted cell apoptosis (P < 0.05). The results also showed that CLPTM1L was a target of miR-494. CONCLUSION: These results show that the expression of miR-494, which can regulate cell growth, invasion and apoptosis of ESCC cells by targeting CLPTM1L, is downregulated in ESCC tumor tissues. The miR-494-CLPTM1L pathway could be further exploited to develop a new approach to treat ESCC
tissue_expression_down	hsa-mir-100	Squamous Cell Carcinoma, Head and Neck	21560177	disease of cellular proliferation	DOID:5520	C76.0	C535575			Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_down	hsa-mir-10a	Squamous Cell Carcinoma, Head and Neck	20145181	disease of cellular proliferation	DOID:5520	C76.0	C535575			downregulation
tissue_expression_down	hsa-mir-130a	Squamous Cell Carcinoma, Head and Neck	21560177	disease of cellular proliferation	DOID:5520	C76.0	C535575			Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_down	hsa-mir-138-1	Squamous Cell Carcinoma, Head and Neck	21969367	disease of cellular proliferation	DOID:5520	C76.0	C535575			In this study, the authors first confirm the microRNA-138-mediated down-regulation of FOSL1 in squamous cell carcinoma (SCC) cell lines.
tissue_expression_down	hsa-mir-138-2	Squamous Cell Carcinoma, Head and Neck	21969367	disease of cellular proliferation	DOID:5520	C76.0	C535575			In this study, the authors first confirm the microRNA-138-mediated down-regulation of FOSL1 in squamous cell carcinoma (SCC) cell lines.
tissue_expression_down	hsa-mir-15a	Squamous Cell Carcinoma, Head and Neck	27896137	disease of cellular proliferation	DOID:5520	C76.0	C535575			Lymph node or perineural invasion is associated with low miR-15a, miR-34c and miR-199b levels in head and neck squamous cell carcinoma.
tissue_expression_down	hsa-mir-181a-1	Squamous Cell Carcinoma, Head and Neck	21274007	disease of cellular proliferation	DOID:5520	C76.0	C535575			deltaNp63alpha-dependent miRNA miR-181a, miR-519a, and miR-374a downregulation in HNSCC,miR-630 upregulation in HNSCC
tissue_expression_down	hsa-mir-181a-2	Squamous Cell Carcinoma, Head and Neck	21274007	disease of cellular proliferation	DOID:5520	C76.0	C535575			deltaNp63alpha-dependent miRNA miR-181a, miR-519a, and miR-374a downregulation in HNSCC,miR-630 upregulation in HNSCC
tissue_expression_down	hsa-mir-197	Squamous Cell Carcinoma, Head and Neck	21560177	disease of cellular proliferation	DOID:5520	C76.0	C535575			Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_down	hsa-mir-199b	Squamous Cell Carcinoma, Head and Neck	27896137	disease of cellular proliferation	DOID:5520	C76.0	C535575			Lymph node or perineural invasion is associated with low miR-15a, miR-34c and miR-199b levels in head and neck squamous cell carcinoma.
tissue_expression_down	hsa-mir-200b	Squamous Cell Carcinoma, Head and Neck	27440205	disease of cellular proliferation	DOID:5520	C76.0	C535575			Additionally, a significant decrease of hsa-miR-200b-5p expression was revealed in tumour-adjacent tissue samples of patients with node positivity.
tissue_expression_down	hsa-mir-203	Squamous Cell Carcinoma, Head and Neck	29667275	disease of cellular proliferation	DOID:5520	C76.0	C535575			miR-26 and miR-125b may be associated with the progression and metastasis of HNSCC, and that miR-203 is associated with a more favourable prognosis.
tissue_expression_down	hsa-mir-29c	Squamous Cell Carcinoma, Head and Neck	27440205	disease of cellular proliferation	DOID:5520	C76.0	C535575			Lower expression of hsa-miR-200b-5p and hsa-miR-29c-3p in HNSCC tumour tissue was associated with  higher tumour grade.
tissue_expression_down	hsa-mir-34c	Squamous Cell Carcinoma, Head and Neck	27896137	disease of cellular proliferation	DOID:5520	C76.0	C535575			Lymph node or perineural invasion is associated with low miR-15a, miR-34c and miR-199b levels in head and neck squamous cell carcinoma.
tissue_expression_down	hsa-mir-375	Squamous Cell Carcinoma, Head and Neck	20145181	disease of cellular proliferation	DOID:5520	C76.0	C535575			underexpression
tissue_expression_down	hsa-mir-491	Squamous Cell Carcinoma, Head and Neck	25677760	disease of cellular proliferation	DOID:5520	C76.0	C535575			Conversely, decreased expressions of miR-153, miR-200c, miR-363, miR-203, miR-17, miR-205, miR-Let-7d, Let-7g, miR-34a, miR-126a, miR-375, miR-491-p5, miR 218, miR-451 and miR-125b were associated with poor prognosis.
tissue_expression_down	hsa-mir-519a-1	Squamous Cell Carcinoma, Head and Neck	21274007	disease of cellular proliferation	DOID:5520	C76.0	C535575			deltaNp63alpha-dependent miRNA miR-181a, miR-519a, and miR-374a downregulation in HNSCC,miR-630 upregulation in HNSCC
tissue_expression_down	hsa-mir-519a-2	Squamous Cell Carcinoma, Head and Neck	21274007	disease of cellular proliferation	DOID:5520	C76.0	C535575			deltaNp63alpha-dependent miRNA miR-181a, miR-519a, and miR-374a downregulation in HNSCC,miR-630 upregulation in HNSCC
tissue_expression_down	hsa-mir-300	Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal	28272707	disease of cellular proliferation	DOID:2876					Reduced miR-300 expression predicts poor prognosis in patients with laryngeal squamous cell carcinoma.
tissue_expression_down	hsa-mir-34c	Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal	26153151	disease of cellular proliferation	DOID:2876					A downregulation of miR-34c-5p in LSCC is independently associated with unfavorable disease-free survival, suggesting that miR-34c-5p might be a promising marker for evaluating the risk of recurrences.
tissue_expression_down	hsa-mir-370	Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal	24055400	disease of cellular proliferation	DOID:2876					In conclusion, our results suggest that miR-370 may function as a tumor suppressor in LSCC through downregulation of FoxM1,suggesting that miR-370 could serve as a novel potential maker for LSCC therapy.
tissue_expression_down	hsa-mir-101-1	Squamous Cell Carcinoma, Lung	20620595	disease of cellular proliferation	DOID:3907	C34.91				miR-101:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC
tissue_expression_down	hsa-mir-101-2	Squamous Cell Carcinoma, Lung	20620595	disease of cellular proliferation	DOID:3907	C34.91				miR-101:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC
tissue_expression_down	hsa-mir-126	Squamous Cell Carcinoma, Lung	20620595	disease of cellular proliferation	DOID:3907	C34.91				miR-126:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC
tissue_expression_down	hsa-mir-15a	Squamous Cell Carcinoma, Lung	20620595	disease of cellular proliferation	DOID:3907	C34.91				miR-15a:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC
tissue_expression_down	hsa-mir-193a	Squamous Cell Carcinoma, Lung	20620595	disease of cellular proliferation	DOID:3907	C34.91				miR-193a-3p:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC
tissue_expression_down	hsa-mir-30a	Squamous Cell Carcinoma, Lung	20620595	disease of cellular proliferation	DOID:3907	C34.91				miR-30a:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC
tissue_expression_down	hsa-mir-30d	Squamous Cell Carcinoma, Lung	20620595	disease of cellular proliferation	DOID:3907	C34.91				miR-30d:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC
tissue_expression_down	hsa-let-7a	Squamous Cell Carcinoma, Oral	26841253	disease of cellular proliferation	DOID:0050866					Downregulation of let-7a was associated with perineural invasion.
tissue_expression_down	hsa-let-7a	Squamous Cell Carcinoma, Oral	25245141	disease of cellular proliferation	DOID:0050866					Comparative analyses showed down-regulation of mir-98 in human samples and up-regulation of let-7a and mir-98 in canine neoplastic samples.
tissue_expression_down	hsa-let-7a	Squamous Cell Carcinoma, Oral	27056547	disease of cellular proliferation	DOID:0050866					let-7a, let-7d, let-7f and miR-16 were downregulated while miR-29b, miR-142-3p, miR-144, miR-203, and miR-223 were upregulated in OSCC
tissue_expression_down	hsa-let-7d	Squamous Cell Carcinoma, Oral	27056547	disease of cellular proliferation	DOID:0050866					let-7a, let-7d, let-7f and miR-16 were downregulated while miR-29b, miR-142-3p, miR-144, miR-203, and miR-223 were upregulated in OSCC
tissue_expression_down	hsa-let-7f	Squamous Cell Carcinoma, Oral	27056547	disease of cellular proliferation	DOID:0050866					let-7a, let-7d, let-7f and miR-16 were downregulated while miR-29b, miR-142-3p, miR-144, miR-203, and miR-223 were upregulated in OSCC
tissue_expression_down	hsa-mir-125a	Squamous Cell Carcinoma, Oral	29480379	disease of cellular proliferation	DOID:0050866					increased miR-21 levels in conjunction with decreased miR-125a levels in saliva of OLP patients may be indicative for a poor prognosis
tissue_expression_down	hsa-mir-125b-2	Squamous Cell Carcinoma, Oral	25482863	disease of cellular proliferation	DOID:0050866					Our results corroborate the previous findings on the overexpression  of mir-21 and downregulation of miR-138 in OSCC. As the expression of miR-184 is controversial in tongue/oral cancer, the downregulation may be specific to tumor anatomical localization. On the other hand, to the best of our knowledge, this is the first report to show the association of miR-155 with tobacco chewing and the downregulation of miR-125b-2* in OSCC. Computational predictions suggest that miR-125b-2* may have a role in alternative splicing.
tissue_expression_down	hsa-mir-135b	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_down	hsa-mir-138	Squamous Cell Carcinoma, Oral	25482863	disease of cellular proliferation	DOID:0050866					Our results corroborate the previous findings on the overexpression  of mir-21 and downregulation of miR-138 in OSCC. As the expression of miR-184 is controversial in tongue/oral cancer, the downregulation may be specific to tumor anatomical localization. On the other hand, to the best of our knowledge, this is the first report to show the association of miR-155 with tobacco chewing and the downregulation of miR-125b-2* in OSCC. Computational predictions suggest that miR-125b-2* may have a role in alternative splicing.
tissue_expression_down	hsa-mir-143	Squamous Cell Carcinoma, Oral	26125902	disease of cellular proliferation	DOID:0050866					Decreased microRNA-143 expression and its tumor suppressive function in human oral squamous cell carcinoma.
tissue_expression_down	hsa-mir-143	Squamous Cell Carcinoma, Oral	26317418	disease of cellular proliferation	DOID:0050866					Overexpression of activin A in OSCCs, which is controlled by downregulation of miR-143/miR-145 cluster, regulates apoptosis, proliferation and invasiveness, and it is clinically correlated with lymph node metastasis and poor survival.
tissue_expression_down	hsa-mir-145	Squamous Cell Carcinoma, Oral	23548968	disease of cellular proliferation	DOID:0050866					Downregulation of miR-145 Expression in Oral Squamous Cell Carcinomas and Its Clinical Significance
tissue_expression_down	hsa-mir-145	Squamous Cell Carcinoma, Oral	26317418	disease of cellular proliferation	DOID:0050866					Overexpression of activin A in OSCCs, which is controlled by downregulation of miR-143/miR-145 cluster, regulates apoptosis, proliferation and invasiveness, and it is clinically correlated with lymph node metastasis and poor survival.
tissue_expression_down	hsa-mir-155	Squamous Cell Carcinoma, Oral	25482863	disease of cellular proliferation	DOID:0050866					Our results corroborate the previous findings on the overexpression  of mir-21 and downregulation of miR-138 in OSCC. As the expression of miR-184 is controversial in tongue/oral cancer, the downregulation may be specific to tumor anatomical localization. On the other hand, to the best of our knowledge, this is the first report to show the association of miR-155 with tobacco chewing and the downregulation of miR-125b-2* in OSCC. Computational predictions suggest that miR-125b-2* may have a role in alternative splicing.
tissue_expression_down	hsa-mir-16	Squamous Cell Carcinoma, Oral	27056547	disease of cellular proliferation	DOID:0050866					let-7a, let-7d, let-7f and miR-16 were downregulated while miR-29b, miR-142-3p, miR-144, miR-203, and miR-223 were upregulated in OSCC
tissue_expression_down	hsa-mir-17	Squamous Cell Carcinoma, Oral	23780339	disease of cellular proliferation	DOID:0050866					miR-17-5p is induced in irradiated OC3 cells and it downregulates p21 protein expression, contributing to the radioresistance of OC3 cells.
tissue_expression_down	hsa-mir-197	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_down	hsa-mir-200b	Squamous Cell Carcinoma, Oral	26841253	disease of cellular proliferation	DOID:0050866					We observed downregulation of miR-200b and miR-203 in 60.0% and 71.4% of the samples
tissue_expression_down	hsa-mir-204	Squamous Cell Carcinoma, Oral	27470356	disease of cellular proliferation	DOID:0050866					The results showed that the expression of miR-204-5p was lower in cancer tissues or cells.
tissue_expression_down	hsa-mir-221	Squamous Cell Carcinoma, Oral	26788506	disease of cellular proliferation	DOID:0050866					In conclusion, downregulation of miR-221 inhibits cell migration and invasion at least partially through targeting MBD2 in the human OSCC cell line UM1.
tissue_expression_down	hsa-mir-224	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_down	hsa-mir-27a	Squamous Cell Carcinoma, Oral	24789751	disease of cellular proliferation	DOID:0050866					A microRNA-27a mimic sensitizes human oral squamous cell carcinoma HSC-4 cells to hyperthermia through downregulation of Hsp110 and Hsp90.
tissue_expression_down	hsa-mir-34a	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_down	hsa-mir-34a	Squamous Cell Carcinoma, Oral	26027785	disease of cellular proliferation	DOID:0050866					We observed downregulation of miR-15a, miR-29a, and miR-34a in 50, 75, and 70% of samples,
tissue_expression_down	hsa-mir-378a	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_down	hsa-mir-520h	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_down	hsa-mir-596	Squamous Cell Carcinoma, Oral	26502662	disease of cellular proliferation	DOID:0050866					Thus, these findings may help clarify the molecular mechanism of the tumor-suppressive effect through down-regulation of LGALS3BP by miR-596 in OSCC cells.
tissue_expression_down	hsa-mir-9	Squamous Cell Carcinoma, Oral	26813876	disease of cellular proliferation	DOID:0050866					Serum miR-9 was downregulated in patients with OSCC and patients with OLK. In addition, low serum miR-9 was correlated with poor prognosis of OSCC, indicating miR-9 might play a tumor suppressive role in OSCC and can serve as a promising biomarker for this deadly disease.
tissue_expression_down	hsa-mir-34a	Squamous Cell Carcinoma, Sinonasal	22624980							miR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis.
tissue_expression_down	hsa-mir-140	Squamous Cell Carcinoma, Skin or Unspecific	23026055	disease of cellular proliferation	DOID:3151	C44.92			HP:0006739	Non-stringent filtering with a non-adjusted p ≤ 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC
tissue_expression_down	hsa-mir-145	Squamous Cell Carcinoma, Skin or Unspecific	23026055	disease of cellular proliferation	DOID:3151	C44.92			HP:0006739	Non-stringent filtering with a non-adjusted p ≤ 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC
tissue_expression_down	hsa-mir-204	Squamous Cell Carcinoma, Skin or Unspecific	27457246	disease of cellular proliferation	DOID:3151	C44.92			HP:0006739	cSCCs display a marked downregulation of miR-204 expression when compared to AK.
tissue_expression_down	hsa-mir-20a	Squamous Cell Carcinoma, Skin or Unspecific	26617873	disease of cellular proliferation	DOID:3151	C44.92			HP:0006739	The expression of miR-20a was lower in CSCC tissues compared with adjacent normal tissues
tissue_expression_down	hsa-mir-26a	Squamous Cell Carcinoma, Skin or Unspecific	23026055	disease of cellular proliferation	DOID:3151	C44.92			HP:0006739	Non-stringent filtering with a non-adjusted p ≤ 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC
tissue_expression_down	hsa-mir-30a	Squamous Cell Carcinoma, Skin or Unspecific	23026055	disease of cellular proliferation	DOID:3151	C44.92			HP:0006739	Non-stringent filtering with a non-adjusted p ≤ 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC
tissue_expression_down	hsa-mir-378	Squamous Cell Carcinoma, Skin or Unspecific	23026055	disease of cellular proliferation	DOID:3151	C44.92			HP:0006739	Non-stringent filtering with a non-adjusted p ≤ 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC
tissue_expression_down	hsa-mir-421	Squamous Cell Carcinoma, Skin or Unspecific	23199656	disease of cellular proliferation	DOID:3151	C44.92			HP:0006739	Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma
tissue_expression_down	hsa-mir-122	Stroke	28751928			I64	D020521	601367	HP:0001297	A Decrease of Brain MicroRNA-122 Level Is an Early Marker of Cerebrovascular Disease in the Stroke-Prone Spontaneously Hypertensive Rat.
tissue_expression_down	hsa-mir-126	Stroke	29642385			I64	D020521	601367	HP:0001297	Moreover, the expression level of miR-126 tended to be downregulated and that of miR-21 tended to be upregulated in ApoE KO mice exposed to the high dose of CS, albeit statistically insignificant
tissue_expression_down	hsa-mir-125b-1	Systemic Lupus Erythematosus	23305626	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	Further analysis showed that the down-regulation of miR-125b, mainly in T cells, was negatively correlated with lupus nephritis
tissue_expression_down	hsa-mir-125b-2	Systemic Lupus Erythematosus	23305626	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	Further analysis showed that the down-regulation of miR-125b, mainly in T cells, was negatively correlated with lupus nephritis
tissue_expression_down	hsa-mir-15b	Systemic Lupus Erythematosus	26144250	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	Moreover, we determined that the expression level of CCND3 was higher, while miR-15b was significantly lower in the B cells from SLE patients and B6.
tissue_expression_down	hsa-mir-181a-1	Systemic Lupus Erythematosus	21385555	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	miR-181-a was significantly downregulated in SLE pediatrics as compared to healthy controls.
tissue_expression_down	hsa-mir-181a-2	Systemic Lupus Erythematosus	21385555	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	miR-181-a was significantly downregulated in SLE pediatrics as compared to healthy controls.
tissue_expression_down	hsa-mir-133b	Testicular Neoplasms	19946373	disease of cellular proliferation	DOID:2998		D013736	273300	HP:0010788	downregulated
tissue_expression_down	hsa-mir-486	Testicular Neoplasms	19946373	disease of cellular proliferation	DOID:2998		D013736	273300	HP:0010788	miR-486-5p: downregulated
tissue_expression_down	hsa-mir-1-1	Thyroid Neoplasms	21537871	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC.
tissue_expression_down	hsa-mir-1-2	Thyroid Neoplasms	21537871	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC.
tissue_expression_down	hsa-mir-133b	Thyroid Neoplasms	21537871	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC.
tissue_expression_down	hsa-mir-138-1	Thyroid Neoplasms	21537871	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC.
tissue_expression_down	hsa-mir-138-2	Thyroid Neoplasms	21537871	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC.
tissue_expression_down	hsa-mir-34b	Thyroid Neoplasms	21537871	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC.
tissue_expression_down	hsa-mir-7	Thyroid Neoplasms	27430434	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	In the present study, miR鈥? was significantly downregulated in thyroid cancer tissues and cells compared with normal thyroid tissue samples.
tissue_expression_down	hsa-mir-146a	Tuberculosis	22964481	disease by infectious agent	DOID:399	A15-A19	D014376			we observed that miR-146a expression is also down-regulated in tuberculosis patients, both in PBMCs and PFMCs while miR-424 levels are elevated only in the peripheral compartments.
tissue_expression_down	hsa-mir-17	Tuberculosis	26513648	disease by infectious agent	DOID:399	A15-A19	D014376			tuberculosis infection leads to downregulation of miR-17 and  concomitant upregulation of its targets Mcl-1 and STAT3
tissue_expression_down	hsa-mir-125b	Tuberculosis, Pulmonary	27363278	disease by infectious agent	DOID:2957	A15	D014397			In PBMCs of children with PTB, miR-125b level is low.
tissue_expression_down	hsa-mir-19b-2	Tuberculosis, Pulmonary	22900099	disease by infectious agent	DOID:2957	A15	D014397			miR-19b-2*: Underexpression
tissue_expression_down	hsa-mir-10b	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-126	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-126	Urinary Bladder Cancer	18596939	urinary system disease	DOID:11054	C67	D001749	109800		miR-126: downregulated
tissue_expression_down	hsa-mir-143	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, downregulated.
tissue_expression_down	hsa-mir-143	Urinary Bladder Cancer	18596939	urinary system disease	DOID:11054	C67	D001749	109800		miR-143: downregulated
tissue_expression_down	hsa-mir-143	Urinary Bladder Cancer	22194833	urinary system disease	DOID:11054	C67	D001749	109800		mir-21 expression increased with worsening clinical diagnosis but that mir-143 was not correlated with histology. These observations were in stark contrast to previous reports involving cervical cancer cell lines in which mir-143 was consistently down-regulated but mir-21 largely unaffected.
tissue_expression_down	hsa-mir-145	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, downregulated.
tissue_expression_down	hsa-mir-145	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-145	Urinary Bladder Cancer	18596939	urinary system disease	DOID:11054	C67	D001749	109800		miR-145: downregulated
tissue_expression_down	hsa-mir-17	Urinary Bladder Cancer	22334592	urinary system disease	DOID:11054	C67	D001749	109800		The anticancer activity of CSL in 253JB-V cells is due to induction of ROS and ROS-mediated induction of Sp repressors (ZBTB4/ZBTB10) through downregulation of miR-27a and miR-20a/17-5p.
tissue_expression_down	hsa-mir-192	Urinary Bladder Cancer	22386240	urinary system disease	DOID:11054	C67	D001749	109800		Compared with controls, the patients with bladder cancer had a lower expression of the miR-200 family, miR-192, and miR-155 in the urinary sediment; lower expression of miR-192; and higher expression of miR-155 in the urinary supernatant.
tissue_expression_down	hsa-mir-19a	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-200a	Urinary Bladder Cancer	22386240	urinary system disease	DOID:11054	C67	D001749	109800		Compared with controls, the patients with bladder cancer had a lower expression of the miR-200 family, miR-192, and miR-155 in the urinary sediment; lower expression of miR-192; and higher expression of miR-155 in the urinary supernatant.
tissue_expression_down	hsa-mir-200b	Urinary Bladder Cancer	22386240	urinary system disease	DOID:11054	C67	D001749	109800		Compared with controls, the patients with bladder cancer had a lower expression of the miR-200 family, miR-192, and miR-155 in the urinary sediment; lower expression of miR-192; and higher expression of miR-155 in the urinary supernatant.
tissue_expression_down	hsa-mir-200c	Urinary Bladder Cancer	22386240	urinary system disease	DOID:11054	C67	D001749	109800		Compared with controls, the patients with bladder cancer had a lower expression of the miR-200 family, miR-192, and miR-155 in the urinary sediment; lower expression of miR-192; and higher expression of miR-155 in the urinary supernatant.
tissue_expression_down	hsa-mir-20a	Urinary Bladder Cancer	22334592	urinary system disease	DOID:11054	C67	D001749	109800		The anticancer activity of CSL in 253JB-V cells is due to induction of ROS and ROS-mediated induction of Sp repressors (ZBTB4/ZBTB10) through downregulation of miR-27a and miR-20a/17-5p.
tissue_expression_down	hsa-mir-214	Urinary Bladder Cancer	23337879	urinary system disease	DOID:11054	C67	D001749	109800		MiR-214 reduces cell survival and enhances cisplatin-induced cytotoxicity via down-regulation of Bcl2l2 in cervical cancer cells
tissue_expression_down	hsa-mir-221	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-27a	Urinary Bladder Cancer	22334592	urinary system disease	DOID:11054	C67	D001749	109800		The anticancer activity of CSL in 253JB-V cells is due to induction of ROS and ROS-mediated induction of Sp repressors (ZBTB4/ZBTB10) through downregulation of miR-27a and miR-20a/17-5p.
tissue_expression_down	hsa-mir-296	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-300	Urinary Bladder Cancer	21223810	urinary system disease	DOID:11054	C67	D001749	109800		In grade I, grade II, grade III, grade I + II + III, infiltrating and non-infiltrating groups, hsa-miR-29b-1* was up-regulated while hsa-miR-923 and hsa-miR-300 were down-regulated
tissue_expression_down	hsa-mir-31	Urinary Bladder Cancer	23408039	urinary system disease	DOID:11054	C67	D001749	109800		Decreased expression of microRNA-31 associates with aggressive tumor progression and poor prognosis in patients with bladder cancer
tissue_expression_down	hsa-mir-378a	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-378b	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-378c	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-378d-1	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-378d-2	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-378e	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-378f	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-378g	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-378h	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-378i	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium.
tissue_expression_down	hsa-mir-145	Urinary System Cancer	29623292	disease of cellular proliferation	DOID:3996	C68.9				the decline of miR-145 expression level have been proved to be able to distinguish bladder cancer patients from non-cancer controls in cell-free urine samples; the elevation of miR-10a and miR-30d was also observed in urine samples from patients with focal segmental glomerulosclerosis
tissue_expression_down	hsa-mir-145	Uveal Melanoma	24762580				C536494	155720	HP:0007716	MiR-145 might act as a tumor suppressor in uveal melanoma, and downregulation of the target IRS-1 might be a potential mechanism.
tissue_expression_down	hsa-mir-145	Vascular Disease [unspecific]	28104472	cardiovascular system disease	DOID:178	I72.9	D000783			Downregulation of miR-145 in venous malformations: Its association with disorganized vessels and sclerotherapy.
tissue_expression_down	hsa-mir-1	Vascular Hypertrophy	17008435							MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy.
tissue_expression_down	hsa-mir-133a	Vascular Hypertrophy	17008435							MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy.
tissue_expression_down	hsa-mir-190b	Vasomotor Rhinitis	28787742	respiratory system disease	DOID:4730	J30.0	D012223			there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p.
tissue_expression_down	hsa-mir-2110	Vasomotor Rhinitis	28787742	respiratory system disease	DOID:4730	J30.0	D012223			there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p.
tissue_expression_down	hsa-mir-449b	Vasomotor Rhinitis	28787742	respiratory system disease	DOID:4730	J30.0	D012223			there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p.
tissue_expression_down	hsa-mir-449c	Vasomotor Rhinitis	28787742	respiratory system disease	DOID:4730	J30.0	D012223			there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p.
tissue_expression_down	hsa-mir-92b	Vasomotor Rhinitis	28787742	respiratory system disease	DOID:4730	J30.0	D012223			there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p.
tissue_expression_down	hsa-mir-27a	Viral Infectious Disease	26700765	disease by infectious agent	DOID:934	A94	D001102			Therefore,type I IFN-induced downregulation of miR-27a can upregulate Siglec1 and TRIM27 expression, feedback inhibiting type I IFN production in antiviral innate response.
tissue_expression_down	hsa-mir-145	Vitiligo	26941046	immune system disease	DOID:12306	L80	D014820		HP:0001045	miR-99b, miR-125b, miR-155 and miR-199a-3p were found to be increased and miR-145 was found to be decreased in the skin of patients with vitiligo.
tissue_expression_down	hsa-mir-9	Waldenstrom Macroglobulinemia	23301642			C88.0	D008258	153600	HP:0005508	The most important changes of microRNA are increased expression of miR-155 and decreased expression of miR-9*. 
tissue_expression_ns	hsa-mir-4793	Necrotizing Enterocolitis	26274503	gastrointestinal system disease	DOID:8677	K55.3	D020345			The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology.
tissue_expression_ns	hsa-mir-29a	Acquired Immunodeficiency Syndrome	28692540	disease by infectious agent	DOID:635	B20	D000163	609423		Unique microRNA expression in the colonic mucosa during chronic HIV-1 infection.
tissue_expression_ns	hsa-mir-221	Acute Liver Failure	24913549			K72	D017114	613070		In liver biopsies, miR-21 and miR-221 displayed a reciprocal expression pattern and were found at lower levels in the spontaneous survivors, whereas miR-122 was elevated  in both serum and liver tissue of those patients.
tissue_expression_ns	hsa-mir-191	Acute Myocardial Infarction	26046358	cardiovascular system disease	DOID:9408	I21	D056989	608446	HP:0001658	This study highlights the stability of miRNAs after death and long-term fixation, validating their use as reliable biomarkers for AMI during postmortem examination.
tissue_expression_ns	hsa-mir-26b	Acute Myocardial Infarction	26046358	cardiovascular system disease	DOID:9408	I21	D056989	608446	HP:0001658	This study highlights the stability of miRNAs after death and long-term fixation, validating their use as reliable biomarkers for AMI during postmortem examination.
tissue_expression_ns	hsa-mir-186	Acute Peritonitis	29360196	gastrointestinal system disease	DOID:8283	K65.0	D010538		HP:0002586	The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA
tissue_expression_ns	hsa-mir-21	Acute Peritonitis	29360196	gastrointestinal system disease	DOID:8283	K65.0	D010538		HP:0002586	The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA
tissue_expression_ns	hsa-mir-222	Acute Peritonitis	29360196	gastrointestinal system disease	DOID:8283	K65.0	D010538		HP:0002586	The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA
tissue_expression_ns	hsa-mir-223	Acute Peritonitis	29360196	gastrointestinal system disease	DOID:8283	K65.0	D010538		HP:0002586	The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA
tissue_expression_ns	hsa-mir-483	Acute Peritonitis	29360196	gastrointestinal system disease	DOID:8283	K65.0	D010538		HP:0002586	The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA
tissue_expression_ns	hsa-mir-18a	Acute Respiratory Distress Syndrome	25070658	respiratory system disease	DOID:11394	J80	D012128			miR-26a, miR-346, miR-135b, miR-30a/b, miR-344, and miR-18a targeted multiple altered mRNAs.
tissue_expression_ns	hsa-mir-135b	Adenocarcinoma, Cervical	25230213	disease of cellular proliferation	DOID:3702					MiR-135b, miR-192, and miR-194 are altered in uterine cervical ACA, and miR-363-3p is an independent favorable prognostic factor in ACA. These miRNAs could be of value as biomarkers for the diagnosis and prognosis of ACA.
tissue_expression_ns	hsa-mir-192	Adenocarcinoma, Cervical	25230213	disease of cellular proliferation	DOID:3702					MiR-135b, miR-192, and miR-194 are altered in uterine cervical ACA, and miR-363-3p is an independent favorable prognostic factor in ACA. These miRNAs could be of value as biomarkers for the diagnosis and prognosis of ACA.
tissue_expression_ns	hsa-mir-194	Adenocarcinoma, Cervical	25230213	disease of cellular proliferation	DOID:3702					MiR-135b, miR-192, and miR-194 are altered in uterine cervical ACA, and miR-363-3p is an independent favorable prognostic factor in ACA. These miRNAs could be of value as biomarkers for the diagnosis and prognosis of ACA.
tissue_expression_ns	hsa-mir-145	Adenocarcinoma, Colon	24791633	disease of cellular proliferation	DOID:234	C18			HP:0040276	Differential expression of microRNA-320a, -145, and-192 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum.
tissue_expression_ns	hsa-mir-192	Adenocarcinoma, Colon	24791633	disease of cellular proliferation	DOID:234	C18			HP:0040276	Differential expression of microRNA-320a, -145, and-193 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum.
tissue_expression_ns	hsa-mir-21	Adenocarcinoma, Colon	19547998	disease of cellular proliferation	DOID:234	C18			HP:0040276	differential expression, with highest expression levels in SSAs; Levels of miR-181b but not miR-21 differed in HPs and normal mucosa; SSAs exhibited both significantly higher miR-181b levels and miR-21 levels; discriminating potential diagnostic value HP from SSA
tissue_expression_ns	hsa-mir-320a	Adenocarcinoma, Colon	24791633	disease of cellular proliferation	DOID:234	C18			HP:0040276	Differential expression of microRNA-320a, -145, and-194 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum.
tissue_expression_ns	hsa-mir-148	Adenocarcinoma, Esophageal	25928282	disease of cellular proliferation	DOID:4914		C562730	133239		Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer.
tissue_expression_ns	hsa-mir-203	Adenocarcinoma, Esophageal	25928282	disease of cellular proliferation	DOID:4914		C562730	133239		Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer.
tissue_expression_ns	hsa-mir-203	Adenocarcinoma, Esophageal	25784377	disease of cellular proliferation	DOID:4914		C562730	133239		We suggest that miRNA expression profiling expands current knowledge in molecular pathology of Barrett's-based carcinogenesis and enables identification of molecular biomarkers for early detection of BE dysplasia and progression to EAC.
tissue_expression_ns	hsa-mir-205	Adenocarcinoma, Esophageal	25784377	disease of cellular proliferation	DOID:4914		C562730	133239		We suggest that miRNA expression profiling expands current knowledge in molecular pathology of Barrett's-based carcinogenesis and enables identification of molecular biomarkers for early detection of BE dysplasia and progression to EAC.
tissue_expression_ns	hsa-mir-21	Adenocarcinoma, Esophageal	25928282	disease of cellular proliferation	DOID:4914		C562730	133239		Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer.
tissue_expression_ns	hsa-mir-210	Adenocarcinoma, Esophageal	25784377	disease of cellular proliferation	DOID:4914		C562730	133239		We suggest that miRNA expression profiling expands current knowledge in molecular pathology of Barrett's-based carcinogenesis and enables identification of molecular biomarkers for early detection of BE dysplasia and progression to EAC.
tissue_expression_ns	hsa-mir-29c	Adenocarcinoma, Esophageal	25928282	disease of cellular proliferation	DOID:4914		C562730	133239		Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer.
tissue_expression_ns	hsa-mir-378	Adenocarcinoma, Esophageal	25784377	disease of cellular proliferation	DOID:4914		C562730	133239		We suggest that miRNA expression profiling expands current knowledge in molecular pathology of Barrett's-based carcinogenesis and enables identification of molecular biomarkers for early detection of BE dysplasia and progression to EAC.
tissue_expression_ns	hsa-let-7	Adenocarcinoma, Gastric	27422560	disease of cellular proliferation	DOID:3717	D37.1	D013274			The integrated analysis of miRNA and gene expression profiles showed the let-7 miRNA family playing a central role in the regulatory relationships.
tissue_expression_ns	hsa-let-7c	Adenocarcinoma, Gastric	27422560	disease of cellular proliferation	DOID:3717	D37.1	D013274			The miRNAs 100, let-7c, 125b and 99a stood out for their association  with the diffuse histological subtype.
tissue_expression_ns	hsa-mir-372	Adenocarcinoma, Gastric	29135097	disease of cellular proliferation	DOID:3717	D37.1	D013274			Analysis of expression profile of miRNA in stomach adenocarcinoma.
tissue_expression_ns	hsa-mir-192	Adenocarcinoma, Gastric-Esophageal Junction	25429911	disease of cellular proliferation	DOID:4944					Comprehensive miRNA profiling showed a differential microRNA expression pattern depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction. Moreover, using single RT-PCR analyses a prognostic impact of miR-222 and miR-302c was detected.
tissue_expression_ns	hsa-mir-21	Adenocarcinoma, Gastric-Esophageal Junction	25429911	disease of cellular proliferation	DOID:4944					Comprehensive miRNA profiling showed a differential microRNA expression pattern depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction. Moreover, using single RT-PCR analyses a prognostic impact of miR-222 and miR-302c was detected.
tissue_expression_ns	hsa-mir-222	Adenocarcinoma, Gastric-Esophageal Junction	25429911	disease of cellular proliferation	DOID:4944					Comprehensive miRNA profiling showed a differential microRNA expression pattern depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction. Moreover, using single RT-PCR analyses a prognostic impact of miR-222 and miR-302c was detected.
tissue_expression_ns	hsa-mir-302c	Adenocarcinoma, Gastric-Esophageal Junction	25429911	disease of cellular proliferation	DOID:4944					Comprehensive miRNA profiling showed a differential microRNA expression pattern depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction. Moreover, using single RT-PCR analyses a prognostic impact of miR-222 and miR-302c was detected.
tissue_expression_ns	hsa-mir-381	Adenocarcinoma, Gastric-Esophageal Junction	25429911	disease of cellular proliferation	DOID:4944					Comprehensive miRNA profiling showed a differential microRNA expression pattern depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction. Moreover, using single RT-PCR analyses a prognostic impact of miR-222 and miR-302c was detected.
tissue_expression_ns	hsa-mir-549	Adenocarcinoma, Gastric-Esophageal Junction	25429911	disease of cellular proliferation	DOID:4944					Comprehensive miRNA profiling showed a differential microRNA expression pattern depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction. Moreover, using single RT-PCR analyses a prognostic impact of miR-222 and miR-302c was detected.
tissue_expression_ns	hsa-let-7b	Adenocarcinoma, Lung	25028925	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b,  -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p.
tissue_expression_ns	hsa-mir-101-1	Adenocarcinoma, Lung	24893932	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality.
tissue_expression_ns	hsa-mir-106b	Adenocarcinoma, Lung	25028925	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b,  -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p.
tissue_expression_ns	hsa-mir-126	Adenocarcinoma, Lung	27277197	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	Low levels of miR-126-3p and miR-451a were associated with poor pathological stage, large tumor diameter and lymph node metastasis
tissue_expression_ns	hsa-mir-149	Adenocarcinoma, Lung	28345454	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	Genome-wide profiling of micro-RNA expression in gefitinib-resistant human lung adenocarcinoma using microarray for the identification of miR-149-5p modulation.
tissue_expression_ns	hsa-mir-151a	Adenocarcinoma, Lung	25028925	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b,  -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p.
tissue_expression_ns	hsa-mir-187	Adenocarcinoma, Lung	24893932	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality.
tissue_expression_ns	hsa-mir-187	Adenocarcinoma, Lung	25028925	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b,  -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p.
tissue_expression_ns	hsa-mir-195	Adenocarcinoma, Lung	24903339	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features.
tissue_expression_ns	hsa-mir-196b	Adenocarcinoma, Lung	24893932	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality.
tissue_expression_ns	hsa-mir-205	Adenocarcinoma, Lung	25028925	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b,  -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p.
tissue_expression_ns	hsa-mir-21	Adenocarcinoma, Lung	27081085	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	We identified a regulatory network including miR-15b and miR-155, and transcription factors with prognostic value in lung cancer.
tissue_expression_ns	hsa-mir-215	Adenocarcinoma, Lung	25028925	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b,  -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p.
tissue_expression_ns	hsa-mir-25	Adenocarcinoma, Lung	24606441	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	Tissue miR-25 expression may be associated with tumor progression and have prognostic implications in female lung ADC patients.
tissue_expression_ns	hsa-mir-30d	Adenocarcinoma, Lung	24903339	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features.
tissue_expression_ns	hsa-mir-31	Adenocarcinoma, Lung	24893932	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality.
tissue_expression_ns	hsa-mir-31	Adenocarcinoma, Lung	27695346	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	MicroRNA expression profiles predict progression and clinical outcome in lung adenocarcinoma.
tissue_expression_ns	hsa-mir-331	Adenocarcinoma, Lung	24893932	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality.
tissue_expression_ns	hsa-mir-34a	Adenocarcinoma, Lung	26104764	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	The expression of microRNA-34a is inversely correlated with c-MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients.
tissue_expression_ns	hsa-mir-370	Adenocarcinoma, Lung	24833665	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	Different morphologic subtypes of lung AC have distinct miRNA expression profiles, and 3 miRNAs encoded at 14q32 (miR-411, miR-370, and miR-376a) were associated with poor survival after lung AC resection.
tissue_expression_ns	hsa-mir-375	Adenocarcinoma, Lung	24893932	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality.
tissue_expression_ns	hsa-mir-376a	Adenocarcinoma, Lung	24833665	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	Different morphologic subtypes of lung AC have distinct miRNA expression profiles, and 3 miRNAs encoded at 14q32 (miR-411, miR-370, and miR-376a) were associated with poor survival after lung AC resection.
tissue_expression_ns	hsa-mir-411	Adenocarcinoma, Lung	24833665	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	Different morphologic subtypes of lung AC have distinct miRNA expression profiles, and 3 miRNAs encoded at 14q32 (miR-411, miR-370, and miR-376a) were associated with poor survival after lung AC resection.
tissue_expression_ns	hsa-mir-449b	Adenocarcinoma, Lung	25028925	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b,  -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p.
tissue_expression_ns	hsa-mir-451a	Adenocarcinoma, Lung	27277197	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	Low levels of miR-126-3p and miR-451a were associated with poor pathological stage, large tumor diameter and lymph node metastasis
tissue_expression_ns	hsa-mir-452	Adenocarcinoma, Lung	28488527	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	Clinical value of miR-452-5p expression in lung adenocarcinoma: A retrospective quantitative real-time polymerase chain reaction study and verification based on The Cancer Genome Atlas and Gene Expression Omnibus databases.
tissue_expression_ns	hsa-mir-512	Adenocarcinoma, Lung	25028925	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b,  -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p.
tissue_expression_ns	hsa-mir-519a-1	Adenocarcinoma, Lung	24893932	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality.
tissue_expression_ns	hsa-mir-520b	Adenocarcinoma, Lung	25028925	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b,  -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p.
tissue_expression_ns	hsa-mir-650	Adenocarcinoma, Lung	23991130	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	miR-650 is a novel prognostic marker in LAD and its expression is a potential indicator of chemosensitivity to docetaxel-based chemotherapy regimen.
tissue_expression_ns	hsa-mir-7	Adenocarcinoma, Lung	28618418	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	Prognostic Significance of microRNA-7 and its Roles in the Regulation of Cisplatin Resistance in Lung Adenocarcinoma.
tissue_expression_ns	hsa-mir-766	Adenocarcinoma, Lung	24893932	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality.
tissue_expression_ns	hsa-mir-774	Adenocarcinoma, Lung	25028925	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b,  -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p.
tissue_expression_ns	hsa-mir-1	Adenocarcinoma, Pancreatic Ductal	29085459	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		Abnormal alterations of miR-1 and miR-214 are associated with clinicopathological features and prognosis of patients with PDAC.
tissue_expression_ns	hsa-mir-100	Adenocarcinoma, Pancreatic Ductal	24575833	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		A microRNA meta-signature for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-143	Adenocarcinoma, Pancreatic Ductal	24575833	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		A microRNA meta-signature for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-148a	Adenocarcinoma, Pancreatic Ductal	24575833	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		A microRNA meta-signature for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-155	Adenocarcinoma, Pancreatic Ductal	24575833	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		A microRNA meta-signature for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-155	Adenocarcinoma, Pancreatic Ductal	21068491	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		MicroRNA-21 and microRNA-155 in pancreatic juice have the potential of becoming biomarkers for diagnosing pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-192	Adenocarcinoma, Pancreatic Ductal	23612862	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		miRNA expression profiling of human PDACs and adjacent normal pancreatic tissues identified 16 upregulated miRNAs including miR-192 and 8 downregulated miRNAs.
tissue_expression_ns	hsa-mir-198	Adenocarcinoma, Pancreatic Ductal	25908274	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-21	Adenocarcinoma, Pancreatic Ductal	25908274	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-21	Adenocarcinoma, Pancreatic Ductal	24575833	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		A microRNA meta-signature for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-21	Adenocarcinoma, Pancreatic Ductal	21068491	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		MicroRNA-21 and microRNA-155 in pancreatic juice have the potential of becoming biomarkers for diagnosing pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-21	Adenocarcinoma, Pancreatic Ductal	27086919	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		We provide further evidence for using miRNAs as diagnostic biomarkers for pancreatic malignancy.
tissue_expression_ns	hsa-mir-214	Adenocarcinoma, Pancreatic Ductal	29085459	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		Abnormal alterations of miR-1 and miR-214 are associated with clinicopathological features and prognosis of patients with PDAC.
tissue_expression_ns	hsa-mir-216	Adenocarcinoma, Pancreatic Ductal	17237814	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		The expression of miR-216 and -217 and lack of expression of miR-133a were identified as characteristic of pancreas tissue.
tissue_expression_ns	hsa-mir-217	Adenocarcinoma, Pancreatic Ductal	25908274	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-217	Adenocarcinoma, Pancreatic Ductal	24575833	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		A microRNA meta-signature for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-217	Adenocarcinoma, Pancreatic Ductal	17237814	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		The expression of miR-216 and -217 and lack of expression of miR-133a were identified as characteristic of pancreas tissue.
tissue_expression_ns	hsa-mir-217	Adenocarcinoma, Pancreatic Ductal	28539816	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		hsa-miR-96 and hsa-miR-217 Expression Down-Regulates with Increasing Dysplasia in Pancreatic Intraepithelial Neoplasias and Intraductal Papillary Mucinous Neoplasms.
tissue_expression_ns	hsa-mir-221	Adenocarcinoma, Pancreatic Ductal	24575833	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		A microRNA meta-signature for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-222	Adenocarcinoma, Pancreatic Ductal	26002251	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		we found significant adjusted HRs for poor OS for high miR-155, high miR-203, and low miR-34a; and unadjusted HRs for high miR-222 and high miR-10b.
tissue_expression_ns	hsa-mir-23a	Adenocarcinoma, Pancreatic Ductal	24575833	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		A microRNA meta-signature for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-31	Adenocarcinoma, Pancreatic Ductal	24575833	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		A microRNA meta-signature for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-34a	Adenocarcinoma, Pancreatic Ductal	25908274	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-375	Adenocarcinoma, Pancreatic Ductal	24575833	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		A microRNA meta-signature for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-96	Adenocarcinoma, Pancreatic Ductal	28539816	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		hsa-miR-96 and hsa-miR-217 Expression Down-Regulates with Increasing Dysplasia in Pancreatic Intraepithelial Neoplasias and Intraductal Papillary Mucinous Neoplasms.
tissue_expression_ns	hsa-mir-141	Adenocarcinoma, Sebaceous	28119291	disease of cellular proliferation	DOID:4839	C44.99	D018266			miRNA-200c and miRNA-141 as potential prognostic biomarkers and regulators of epithelial-mesenchymal transition in eyelid sebaceous gland carcinoma.
tissue_expression_ns	hsa-mir-200c	Adenocarcinoma, Sebaceous	28119291	disease of cellular proliferation	DOID:4839	C44.99	D018266			miRNA-200c and miRNA-141 as potential prognostic biomarkers and regulators of epithelial-mesenchymal transition in eyelid sebaceous gland carcinoma.
tissue_expression_ns	hsa-mir-195	Adrenal Cortex Neoplasms	29429354	disease of cellular proliferation	DOID:0050891	C74.0	D000306		HP:0100641	Several tissue microRNAs, such as miR-483-5p, miR-503, miR-210, miR-335 and miR-195 were  found to be differentially expressed among benign and malignant adrenocortical tumours
tissue_expression_ns	hsa-mir-210	Adrenal Cortex Neoplasms	29429354	disease of cellular proliferation	DOID:0050891	C74.0	D000306		HP:0100641	Several tissue microRNAs, such as miR-483-5p, miR-503, miR-210, miR-335 and miR-195 were  found to be differentially expressed among benign and malignant adrenocortical tumours
tissue_expression_ns	hsa-mir-335	Adrenal Cortex Neoplasms	29429354	disease of cellular proliferation	DOID:0050891	C74.0	D000306		HP:0100641	Several tissue microRNAs, such as miR-483-5p, miR-503, miR-210, miR-335 and miR-195 were  found to be differentially expressed among benign and malignant adrenocortical tumours
tissue_expression_ns	hsa-mir-483	Adrenal Cortex Neoplasms	29429354	disease of cellular proliferation	DOID:0050891	C74.0	D000306		HP:0100641	Several tissue microRNAs, such as miR-483-5p, miR-503, miR-210, miR-335 and miR-195 were  found to be differentially expressed among benign and malignant adrenocortical tumours
tissue_expression_ns	hsa-mir-503	Adrenal Cortex Neoplasms	29429354	disease of cellular proliferation	DOID:0050891	C74.0	D000306		HP:0100641	Several tissue microRNAs, such as miR-483-5p, miR-503, miR-210, miR-335 and miR-195 were  found to be differentially expressed among benign and malignant adrenocortical tumours
tissue_expression_ns	hsa-mir-181a	African Swine Fever	29041944				D000357			Differential expression of porcine microRNAs in African swine fever virus infected pigs: a proof-of-concept study.
tissue_expression_ns	hsa-let-7g	Alzheimer Disease	26497684	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease.
tissue_expression_ns	hsa-mir-10a	Alzheimer Disease	26497684	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease.
tissue_expression_ns	hsa-mir-153	Alzheimer Disease	26497684	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease.
tissue_expression_ns	hsa-mir-409	Alzheimer Disease	26497684	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease.
tissue_expression_ns	hsa-mir-129	Amyotrophic Lateral Sclerosis	27773796	nervous system disease	DOID:332	G12.21	D000690	PS105400	HP:0007354	MicroRNA expression profiles of multiple system atrophy from formalin-fixed paraffin-embedded samples.
tissue_expression_ns	hsa-mir-132	Amyotrophic Lateral Sclerosis	27773796	nervous system disease	DOID:332	G12.21	D000690	PS105400	HP:0007354	MicroRNA expression profiles of multiple system atrophy from formalin-fixed paraffin-embedded samples.
tissue_expression_ns	hsa-mir-1	Aortic Aneurysm	27939432	cardiovascular system disease	DOID:3627	I71	D001014	100070	HP:0004942	Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization.
tissue_expression_ns	hsa-mir-143	Aortic Aneurysm	27939432	cardiovascular system disease	DOID:3627	I71	D001014	100070	HP:0004942	Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization.
tissue_expression_ns	hsa-mir-145	Aortic Aneurysm	27939432	cardiovascular system disease	DOID:3627	I71	D001014	100070	HP:0004942	Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization.
tissue_expression_ns	hsa-mir-22	Aortic Aneurysm	27939432	cardiovascular system disease	DOID:3627	I71	D001014	100070	HP:0004942	Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization.
tissue_expression_ns	hsa-mir-378a	Aortic Aneurysm	27939432	cardiovascular system disease	DOID:3627	I71	D001014	100070	HP:0004942	Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization.
tissue_expression_ns	hsa-mir-29a	Aortic Aneurysm, Thoracic	21334170	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		dysregulated
tissue_expression_ns	hsa-mir-29b-1	Aortic Aneurysm, Thoracic	21334170	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		dysregulated
tissue_expression_ns	hsa-mir-29b-2	Aortic Aneurysm, Thoracic	21334170	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		dysregulated
tissue_expression_ns	hsa-mir-29c	Aortic Aneurysm, Thoracic	21334170	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		dysregulated
tissue_expression_ns	hsa-mir-30a	Aortic Aneurysm, Thoracic	21334170	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		dysregulated
tissue_expression_ns	hsa-mir-30b	Aortic Aneurysm, Thoracic	21334170	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		dysregulated
tissue_expression_ns	hsa-mir-30c-1	Aortic Aneurysm, Thoracic	21334170	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		dysregulated
tissue_expression_ns	hsa-mir-30c-2	Aortic Aneurysm, Thoracic	21334170	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		dysregulated
tissue_expression_ns	hsa-mir-30d	Aortic Aneurysm, Thoracic	21334170	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		dysregulated
tissue_expression_ns	hsa-mir-30e	Aortic Aneurysm, Thoracic	21334170	cardiovascular system disease	DOID:14004	I71.1-.2	D017545	607086		dysregulated
tissue_expression_ns	hsa-mir-146b	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-193a	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-194	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-1972	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-200b	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-21	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-29b	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-301a	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-3138	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-34a	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-3663	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-505	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-513a	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-516a	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-575	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-630	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-636	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-718	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-mir-99b	Aortic Stenosis	27579316	cardiovascular system disease	DOID:1712	I35.0	D001024	109730	HP:0001650	MicroRNA Expression Signature in Degenerative Aortic Stenosis.
tissue_expression_ns	hsa-let-7d	Asthma	23885321	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Differential expression of miR-1248, miR-26a, Let-7a, and Let-7d were observed in asthmatic patients compared to controls.
tissue_expression_ns	hsa-mir-146a	Asthma	25217662	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	MicroRNA-146a and microRNA-146b expression and anti-inflammatory function in human airway smooth muscle.
tissue_expression_ns	hsa-mir-146b	Asthma	25217662	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	MicroRNA-146a and microRNA-146b expression and anti-inflammatory function in human airway smooth muscle.
tissue_expression_ns	hsa-mir-155	Asthma	28199728	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Altered miR-155 Expression in Allergic Asthmatic Airways.
tissue_expression_ns	hsa-mir-210	Astrocytoma	24729345	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	MiR-210 levels can be potentially established as a biomarker for pathological diagnosis of malignant astrocytic tumour progression. In addition,the expression of miR-210 can be utilized as an additional identification measure of glioma tumour origin.
tissue_expression_ns	hsa-mir-10a	Atherosclerosis	28403739	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Hydrogen Peroxide and Lipopolysaccharide Differentially Affect the Expression of MicroRNAs 10a, 33a, 21, 221 in Endothelial Cells Before and After Coculture With Monocytes.
tissue_expression_ns	hsa-mir-143	Atherosclerosis	20351064	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Thus, dysregulation of the miR-143 and -145 genes is causally involved in the aberrant SMC plasticity encountered during vascular disease, in part through the up-regulation of an autoregulatory loop that promotes podosome formation.
tissue_expression_ns	hsa-mir-143	Atherosclerosis	27631489	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Differential Expression of MicroRNAs in Endarterectomy Specimens Taken from Patients with Asymptomatic and Symptomatic Carotid Plaques.
tissue_expression_ns	hsa-mir-145	Atherosclerosis	20351064	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Thus, dysregulation of the miR-143 and -145 genes is causally involved in the aberrant SMC plasticity encountered during vascular disease, in part through the up-regulation of an autoregulatory loop that promotes podosome formation.
tissue_expression_ns	hsa-mir-155	Atherosclerosis	28234622	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	CagA-positive and CagA-negative Helicobacter pylori strains differentially affect the expression of micro RNAs 21, 92a, 155 and 663 in human umbilical vein endothelial cells.
tissue_expression_ns	hsa-mir-21	Atherosclerosis	27631489	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Differential Expression of MicroRNAs in Endarterectomy Specimens Taken from Patients with Asymptomatic and Symptomatic Carotid Plaques.
tissue_expression_ns	hsa-mir-21	Atherosclerosis	28234622	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	CagA-positive and CagA-negative Helicobacter pylori strains differentially affect the expression of micro RNAs 21, 92a, 155 and 663 in human umbilical vein endothelial cells.
tissue_expression_ns	hsa-mir-21	Atherosclerosis	28403739	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Hydrogen Peroxide and Lipopolysaccharide Differentially Affect the Expression of MicroRNAs 10a, 33a, 21, 221 in Endothelial Cells Before and After Coculture With Monocytes.
tissue_expression_ns	hsa-mir-221	Atherosclerosis	28403739	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Hydrogen Peroxide and Lipopolysaccharide Differentially Affect the Expression of MicroRNAs 10a, 33a, 21, 221 in Endothelial Cells Before and After Coculture With Monocytes.
tissue_expression_ns	hsa-mir-33a	Atherosclerosis	28403739	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Hydrogen Peroxide and Lipopolysaccharide Differentially Affect the Expression of MicroRNAs 10a, 33a, 21, 221 in Endothelial Cells Before and After Coculture With Monocytes.
tissue_expression_ns	hsa-mir-663	Atherosclerosis	28234622	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	CagA-positive and CagA-negative Helicobacter pylori strains differentially affect the expression of micro RNAs 21, 92a, 155 and 663 in human umbilical vein endothelial cells.
tissue_expression_ns	hsa-mir-92a	Atherosclerosis	28234622	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	CagA-positive and CagA-negative Helicobacter pylori strains differentially affect the expression of micro RNAs 21, 92a, 155 and 663 in human umbilical vein endothelial cells.
tissue_expression_ns	hsa-mir-1	Atrial Fibrillation	24461008	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	AF alters the miRNA expression profiles of the left atria of MS patients. These findings may be useful for the biological understanding of AF in MS patients.
tissue_expression_ns	hsa-mir-106a	Atrial Fibrillation	24824214	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation.
tissue_expression_ns	hsa-mir-106b	Atrial Fibrillation	24824214	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation.
tissue_expression_ns	hsa-mir-144	Atrial Fibrillation	24824214	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation.
tissue_expression_ns	hsa-mir-15b	Atrial Fibrillation	24824214	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation.
tissue_expression_ns	hsa-mir-19	Atrial Fibrillation	24824214	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation.
tissue_expression_ns	hsa-mir-208a	Atrial Fibrillation	24824214	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation.
tissue_expression_ns	hsa-mir-21	Atrial Fibrillation	24069193	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	The expression of miRNA-21 in human atrial tissue was found to be related to atrial fibrosis and might affect AF occurrence, indicating its usefulness as a biomarker for cardiac surgery management.
tissue_expression_ns	hsa-mir-23a	Atrial Fibrillation	24824214	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation.
tissue_expression_ns	hsa-mir-25	Atrial Fibrillation	24824214	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation.
tissue_expression_ns	hsa-mir-26a	Atrial Fibrillation	24461008	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	AF alters the miRNA expression profiles of the left atria of MS patients. These findings may be useful for the biological understanding of AF in MS patients.
tissue_expression_ns	hsa-mir-30a	Atrial Fibrillation	24824214	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation.
tissue_expression_ns	hsa-mir-3613	Atrial Fibrillation	24461008	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	AF alters the miRNA expression profiles of the left atria of MS patients. These findings may be useful for the biological understanding of AF in MS patients.
tissue_expression_ns	hsa-mir-363	Atrial Fibrillation	24824214	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation.
tissue_expression_ns	hsa-mir-451	Atrial Fibrillation	24824214	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation.
tissue_expression_ns	hsa-mir-466	Atrial Fibrillation	24461008	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	AF alters the miRNA expression profiles of the left atria of MS patients. These findings may be useful for the biological understanding of AF in MS patients.
tissue_expression_ns	hsa-mir-486	Atrial Fibrillation	24824214	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation.
tissue_expression_ns	hsa-mir-574	Atrial Fibrillation	24461008	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	AF alters the miRNA expression profiles of the left atria of MS patients. These findings may be useful for the biological understanding of AF in MS patients.
tissue_expression_ns	hsa-mir-590	Atrial Fibrillation	24824214	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation.
tissue_expression_ns	hsa-mir-93	Atrial Fibrillation	24824214	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation.
tissue_expression_ns	hsa-mir-146a	Autism Spectrum Disorder	26753090	disease of mental health	DOID:0060041	F84.0	D000067877	209850	HP:0000729	We identified a signature of four miRNAs (miR-146a, miR-221, miR-654-5p, and miR-656) commonly deregulated in ASD.
tissue_expression_ns	hsa-mir-221	Autism Spectrum Disorder	26753090	disease of mental health	DOID:0060041	F84.0	D000067877	209850	HP:0000729	We identified a signature of four miRNAs (miR-146a, miR-221, miR-654-5p, and miR-656) commonly deregulated in ASD.
tissue_expression_ns	hsa-mir-106a	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-106a: deregulation
tissue_expression_ns	hsa-mir-106b	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-106b: deregulation
tissue_expression_ns	hsa-mir-129-1	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-129: deregulation
tissue_expression_ns	hsa-mir-129-2	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-129: deregulation
tissue_expression_ns	hsa-mir-132	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-132: deregulation
tissue_expression_ns	hsa-mir-140	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-140: deregulation
tissue_expression_ns	hsa-mir-146b	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-146b: deregulation
tissue_expression_ns	hsa-mir-148b	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-148b: deregulation
tissue_expression_ns	hsa-mir-15a	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-15a: deregulation
tissue_expression_ns	hsa-mir-15b	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-15b: deregulation
tissue_expression_ns	hsa-mir-181d	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-181d: deregulation
tissue_expression_ns	hsa-mir-193b	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-193b: deregulation
tissue_expression_ns	hsa-mir-21	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-21: deregulation
tissue_expression_ns	hsa-mir-212	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-212: deregulation
tissue_expression_ns	hsa-mir-23a	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-23a: deregulation
tissue_expression_ns	hsa-mir-27a	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-27a: deregulation
tissue_expression_ns	hsa-mir-381	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-381: deregulation
tissue_expression_ns	hsa-mir-431	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-431: deregulation
tissue_expression_ns	hsa-mir-432	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-432: deregulation
tissue_expression_ns	hsa-mir-484	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-484: deregulation
tissue_expression_ns	hsa-mir-539	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-539: deregulation
tissue_expression_ns	hsa-mir-550a-1	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-550: deregulation
tissue_expression_ns	hsa-mir-550a-2	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-550: deregulation
tissue_expression_ns	hsa-mir-598	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-598: deregulation
tissue_expression_ns	hsa-mir-652	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-652: deregulation
tissue_expression_ns	hsa-mir-7-1	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-7: deregulation
tissue_expression_ns	hsa-mir-7-2	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-7: deregulation
tissue_expression_ns	hsa-mir-7-3	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-7: deregulation
tissue_expression_ns	hsa-mir-93	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-93: deregulation
tissue_expression_ns	hsa-mir-95	Autistic Disorder	18563458	disease of mental health	DOID:12849	F84.0	D001321	209850		miR-95: deregulation
tissue_expression_ns	hsa-mir-199a	Autoimmune Diseases [unspecific]	27871116				D001327	607836	HP:0002960	Excess glucocorticoids have been shown to modulate the expression of miRNAs, including miR-29a, miR-34a-5p, and miR-199a-5p, which regulate the proliferation and differentiation of osteoblast lineage cells
tissue_expression_ns	hsa-mir-223	Autoimmune Diseases [unspecific]	26879236				D001327	607836	HP:0002960	using co-expression analysis of miRNA expression  levels we showed that multiple miRNA contribute to multiple pathways that might be involved in pathogenesis of autoimmune skin blistering disease.
tissue_expression_ns	hsa-mir-29a	Autoimmune Diseases [unspecific]	27871116				D001327	607836	HP:0002960	Excess glucocorticoids have been shown to modulate the expression of miRNAs, including miR-29a, miR-34a-5p, and miR-199a-5p, which regulate the proliferation and differentiation of osteoblast lineage cells
tissue_expression_ns	hsa-mir-34a	Autoimmune Diseases [unspecific]	27871116				D001327	607836	HP:0002960	Excess glucocorticoids have been shown to modulate the expression of miRNAs, including miR-29a, miR-34a-5p, and miR-199a-5p, which regulate the proliferation and differentiation of osteoblast lineage cells
tissue_expression_ns	hsa-mir-155	Autoimmune Thyroiditis	24554510	immune system disease	DOID:7188	E06.3	D013967	109100		microRNA expressions in CD4+ and CD8+ T-cell subsets in autoimmune thyroid diseases.
tissue_expression_ns	hsa-mir-200a	Autoimmune Thyroiditis	24554510	immune system disease	DOID:7188	E06.3	D013967	109100		microRNA expressions in CD4+ and CD8+ T-cell subsets in autoimmune thyroid diseases.
tissue_expression_ns	hsa-mir-17	Azoospermia	19210773	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	miR-17: deregulation
tissue_expression_ns	hsa-mir-18a	Azoospermia	19210773	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	miR-18a: deregulation
tissue_expression_ns	hsa-mir-19a	Azoospermia	19210773	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	miR-19a: deregulation
tissue_expression_ns	hsa-mir-19b-1	Azoospermia	19210773	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	miR-19b: deregulation
tissue_expression_ns	hsa-mir-19b-2	Azoospermia	19210773	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	miR-19b: deregulation
tissue_expression_ns	hsa-mir-20a	Azoospermia	19210773	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	miR-20a: deregulation
tissue_expression_ns	hsa-mir-302a	Azoospermia	19210773	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	miR-302a: deregulation
tissue_expression_ns	hsa-mir-371a	Azoospermia	19210773	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	mir-371: deregulation
tissue_expression_ns	hsa-mir-372	Azoospermia	19210773	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	mir-372: deregulation
tissue_expression_ns	hsa-mir-373	Azoospermia	19210773	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	mir-373: deregulation
tissue_expression_ns	hsa-mir-383	Azoospermia	19210773	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	miR-383: deregulation
tissue_expression_ns	hsa-mir-491	Azoospermia	19210773	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	miR-491-3p: deregulation
tissue_expression_ns	hsa-mir-520d	Azoospermia	19210773	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	miR-520d-3p: deregulation
tissue_expression_ns	hsa-mir-92a-1	Azoospermia	19210773	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	miR-92a: deregulation
tissue_expression_ns	hsa-mir-92a-2	Azoospermia	19210773	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	miR-92a: deregulation
tissue_expression_ns	hsa-mir-127	Balkan Nephropathy	27218105	urinary system disease	DOID:3052	N15.0	D001449	124100		 Only three microRNAs (hsa-miR-127-3p, hsa-miR-154-5p, and hsa-miR-30a-5p) were downregulated among BEN-UTUC, and one microRNA (hsa-miR-663b) was downregulated among non-BEN-UTUC samples
tissue_expression_ns	hsa-mir-154	Balkan Nephropathy	27218105	urinary system disease	DOID:3052	N15.0	D001449	124100		 Only three microRNAs (hsa-miR-127-3p, hsa-miR-154-5p, and hsa-miR-30a-5p) were downregulated among BEN-UTUC, and one microRNA (hsa-miR-663b) was downregulated among non-BEN-UTUC samples
tissue_expression_ns	hsa-mir-30a	Balkan Nephropathy	27218105	urinary system disease	DOID:3052	N15.0	D001449	124100		 Only three microRNAs (hsa-miR-127-3p, hsa-miR-154-5p, and hsa-miR-30a-5p) were downregulated among BEN-UTUC, and one microRNA (hsa-miR-663b) was downregulated among non-BEN-UTUC samples
tissue_expression_ns	hsa-mir-663b	Balkan Nephropathy	27218105	urinary system disease	DOID:3052	N15.0	D001449	124100		 Only three microRNAs (hsa-miR-127-3p, hsa-miR-154-5p, and hsa-miR-30a-5p) were downregulated among BEN-UTUC, and one microRNA (hsa-miR-663b) was downregulated among non-BEN-UTUC samples
tissue_expression_ns	hsa-let-7a-1	Barrett Esophagus	21407181	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	differential expression between Barrett Esophagus patients with and without dysplasia.
tissue_expression_ns	hsa-let-7a-2	Barrett Esophagus	21407181	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	differential expression between Barrett Esophagus patients with and without dysplasia.
tissue_expression_ns	hsa-let-7a-3	Barrett Esophagus	21407181	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	differential expression between Barrett Esophagus patients with and without dysplasia.
tissue_expression_ns	hsa-mir-145	Barrett Esophagus	21407181	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	differential expression between Barrett Esophagus patients with and without dysplasia.
tissue_expression_ns	hsa-mir-15b	Barrett Esophagus	21407181	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	differential expression between Barrett Esophagus patients with and without dysplasia.
tissue_expression_ns	hsa-mir-192	Barrett Esophagus	26572780	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	MicroRNAs miR-192, -194, -203, -205, and -215 are promising tissue biomarkers for diagnosing BE. Cross-sectional data suggest that microRNAs may have a limited role in separating BE from HGD/EAC epithelia but need further testing in longitudinal follow-up studies.
tissue_expression_ns	hsa-mir-194	Barrett Esophagus	26572780	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	MicroRNAs miR-192, -194, -203, -205, and -215 are promising tissue biomarkers for diagnosing BE. Cross-sectional data suggest that microRNAs may have a limited role in separating BE from HGD/EAC epithelia but need further testing in longitudinal follow-up studies.
tissue_expression_ns	hsa-mir-196a-1	Barrett Esophagus	19342367	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	miR-196a: Marker of Progression
tissue_expression_ns	hsa-mir-196a-2	Barrett Esophagus	19342367	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	miR-196a: Marker of Progression
tissue_expression_ns	hsa-mir-203	Barrett Esophagus	21407181	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	differential expression between Barrett Esophagus patients with and without dysplasia.
tissue_expression_ns	hsa-mir-203	Barrett Esophagus	26572780	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	MicroRNAs miR-192, -194, -203, -205, and -215 are promising tissue biomarkers for diagnosing BE. Cross-sectional data suggest that microRNAs may have a limited role in separating BE from HGD/EAC epithelia but need further testing in longitudinal follow-up studies.
tissue_expression_ns	hsa-mir-205	Barrett Esophagus	26572780	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	MicroRNAs miR-192, -194, -203, -205, and -215 are promising tissue biomarkers for diagnosing BE. Cross-sectional data suggest that microRNAs may have a limited role in separating BE from HGD/EAC epithelia but need further testing in longitudinal follow-up studies.
tissue_expression_ns	hsa-mir-21	Barrett Esophagus	21407181	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	differential expression between Barrett Esophagus patients with and without dysplasia.
tissue_expression_ns	hsa-mir-215	Barrett Esophagus	26572780	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	MicroRNAs miR-192, -194, -203, -205, and -215 are promising tissue biomarkers for diagnosing BE. Cross-sectional data suggest that microRNAs may have a limited role in separating BE from HGD/EAC epithelia but need further testing in longitudinal follow-up studies.
tissue_expression_ns	hsa-mir-486	Barrett Esophagus	21407181	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	differential expression between Barrett Esophagus patients with and without dysplasia.
tissue_expression_ns	hsa-mir-100	Bladder Neoplasms	26489968			C67	D001749	109800	HP:0009725	MiRNAs detected in urine and serum/plasma will demonstrate their potentiality to describe the variegated scenario of BC and to become relevant clinical markers.
tissue_expression_ns	hsa-mir-106b	Bladder Neoplasms	23945108			C67	D001749	109800	HP:0009725	miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome.
tissue_expression_ns	hsa-mir-125b	Bladder Neoplasms	23945108			C67	D001749	109800	HP:0009725	miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome.
tissue_expression_ns	hsa-mir-125b	Bladder Neoplasms	25014919			C67	D001749	109800	HP:0009725	The results revealed a unique microRNA expression signature in the urine supernatants of UCB patients for the development of molecular diagnostic tests. An effective cell-free urinary microRNA-based model was developed using a combined index of the levels of microRNA-99a and microRNA-125b to detect UCB with good discriminating power, high sensitivity and high specificity.
tissue_expression_ns	hsa-mir-126	Bladder Neoplasms	26576778			C67	D001749	109800	HP:0009725	MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies.
tissue_expression_ns	hsa-mir-130a	Bladder Neoplasms	23945108			C67	D001749	109800	HP:0009725	miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome.
tissue_expression_ns	hsa-mir-130b	Bladder Neoplasms	23945108			C67	D001749	109800	HP:0009725	miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome.
tissue_expression_ns	hsa-mir-139	Bladder Neoplasms	23945108			C67	D001749	109800	HP:0009725	miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome.
tissue_expression_ns	hsa-mir-141	Bladder Neoplasms	23945108			C67	D001749	109800	HP:0009725	miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome.
tissue_expression_ns	hsa-mir-141	Bladder Neoplasms	27357429			C67	D001749	109800	HP:0009725	two types of cancer showed opposite expression patterns for miR-200 family miRNAs
tissue_expression_ns	hsa-mir-141	Bladder Neoplasms	19945312			C67	D001749	109800	HP:0009725	The diagnostic test, based on the three most discriminatory miRNAs in our panel (miR-200c, miR-141, and miR-30b), showed a sensitivity of 100% and a specificity of 96.2%. Such a panel of miRNAs has the potential to identify invasive bladder tumors misclassified in pathologic assessment of bladder biopsy specimens.
tissue_expression_ns	hsa-mir-145	Bladder Neoplasms	23945108			C67	D001749	109800	HP:0009725	miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome.
tissue_expression_ns	hsa-mir-145	Bladder Neoplasms	22961325			C67	D001749	109800	HP:0009725	Assessment of miR-145 levels was able to distinguish bladder cancer patients from non-cancer controls
tissue_expression_ns	hsa-mir-150	Bladder Neoplasms	26576778			C67	D001749	109800	HP:0009725	MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies.
tissue_expression_ns	hsa-mir-15b	Bladder Neoplasms	26576778			C67	D001749	109800	HP:0009725	MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies.
tissue_expression_ns	hsa-mir-195	Bladder Neoplasms	24520312			C67	D001749	109800	HP:0009725	The microRNA expression signature of bladder cancer by deep sequencing: the functional significance of the miR-195/497 cluster.
tissue_expression_ns	hsa-mir-199a	Bladder Neoplasms	23945108			C67	D001749	109800	HP:0009725	miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome.
tissue_expression_ns	hsa-mir-200	Bladder Neoplasms	27357429			C67	D001749	109800	HP:0009725	two types of cancer showed opposite expression patterns for miR-200 family miRNAs
tissue_expression_ns	hsa-mir-200a	Bladder Neoplasms	23945108			C67	D001749	109800	HP:0009725	miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome.
tissue_expression_ns	hsa-mir-200a	Bladder Neoplasms	27357429			C67	D001749	109800	HP:0009725	two types of cancer showed opposite expression patterns for miR-200 family miRNAs
tissue_expression_ns	hsa-mir-200b	Bladder Neoplasms	27357429			C67	D001749	109800	HP:0009725	two types of cancer showed opposite expression patterns for miR-200 family miRNAs
tissue_expression_ns	hsa-mir-200c	Bladder Neoplasms	26576778			C67	D001749	109800	HP:0009725	MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies.
tissue_expression_ns	hsa-mir-200c	Bladder Neoplasms	27357429			C67	D001749	109800	HP:0009725	two types of cancer showed opposite expression patterns for miR-200 family miRNAs
tissue_expression_ns	hsa-mir-200c	Bladder Neoplasms	19945312			C67	D001749	109800	HP:0009725	The diagnostic test, based on the three most discriminatory miRNAs in our panel (miR-200c, miR-141, and miR-30b), showed a sensitivity of 100% and a specificity of 96.2%. Such a panel of miRNAs has the potential to identify invasive bladder tumors misclassified in pathologic assessment of bladder biopsy specimens.
tissue_expression_ns	hsa-mir-205	Bladder Neoplasms	26576778			C67	D001749	109800	HP:0009725	MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies.
tissue_expression_ns	hsa-mir-205	Bladder Neoplasms	23945108			C67	D001749	109800	HP:0009725	miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome.
tissue_expression_ns	hsa-mir-20a	Bladder Neoplasms	23945108			C67	D001749	109800	HP:0009725	miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome.
tissue_expression_ns	hsa-mir-21	Bladder Neoplasms	26576778			C67	D001749	109800	HP:0009725	MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies.
tissue_expression_ns	hsa-mir-210	Bladder Neoplasms	27441495			C67	D001749	109800	HP:0009725	High miR-210 may reflect hypoxia in bladder cancer. However, its ability to predict benefit from hypoxia modification does not improve upon other  hypoxia markers. Investigation as part of a miRNA hypoxia signature may reveal the full potential of miR-210.
tissue_expression_ns	hsa-mir-214	Bladder Neoplasms	23945108			C67	D001749	109800	HP:0009725	miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome.
tissue_expression_ns	hsa-mir-222	Bladder Neoplasms	23945108			C67	D001749	109800	HP:0009725	miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome.
tissue_expression_ns	hsa-mir-29b	Bladder Neoplasms	26576778			C67	D001749	109800	HP:0009725	MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies.
tissue_expression_ns	hsa-mir-3007a	Bladder Neoplasms	26576778			C67	D001749	109800	HP:0009725	MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies.
tissue_expression_ns	hsa-mir-30b	Bladder Neoplasms	19945312			C67	D001749	109800	HP:0009725	The diagnostic test, based on the three most discriminatory miRNAs in our panel (miR-200c, miR-141, and miR-30b), showed a sensitivity of 100% and a specificity of 96.2%. Such a panel of miRNAs has the potential to identify invasive bladder tumors misclassified in pathologic assessment of bladder biopsy specimens.
tissue_expression_ns	hsa-mir-4454	Bladder Neoplasms	26576778			C67	D001749	109800	HP:0009725	MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies.
tissue_expression_ns	hsa-mir-497	Bladder Neoplasms	24520312			C67	D001749	109800	HP:0009725	The microRNA expression signature of bladder cancer by deep sequencing: the functional significance of the miR-195/497 cluster.
tissue_expression_ns	hsa-mir-720	Bladder Neoplasms	26576778			C67	D001749	109800	HP:0009725	MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies.
tissue_expression_ns	hsa-mir-93	Bladder Neoplasms	26576778			C67	D001749	109800	HP:0009725	MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies.
tissue_expression_ns	hsa-mir-96	Bladder Neoplasms	25511320			C67	D001749	109800	HP:0009725	Urinary miRNA-96 is a good noninvasive diagnostic biomarker for bladder cancer.
tissue_expression_ns	hsa-mir-99a	Bladder Neoplasms	25014919			C67	D001749	109800	HP:0009725	The results revealed a unique microRNA expression signature in the urine supernatants of UCB patients for the development of molecular diagnostic tests. An effective cell-free urinary microRNA-based model was developed using a combined index of the levels of microRNA-99a and microRNA-125b to detect UCB with good discriminating power, high sensitivity and high specificity.
tissue_expression_ns	hsa-mir-133a	Bone Disease [unspecific]	21108928	musculoskeletal system disease	DOID:0080001	M89.9	D001847			The expression of miRNAs, including miR-18a, miR-133a, miR-141 and miR-19a, was significantly altered in the PDLSCs cultured with ibandronate.
tissue_expression_ns	hsa-mir-141	Bone Disease [unspecific]	21108928	musculoskeletal system disease	DOID:0080001	M89.9	D001847			The expression of miRNAs, including miR-18a, miR-133a, miR-141 and miR-19a, was significantly altered in the PDLSCs cultured with ibandronate.
tissue_expression_ns	hsa-mir-18a	Bone Disease [unspecific]	21108928	musculoskeletal system disease	DOID:0080001	M89.9	D001847			The expression of miRNAs, including miR-18a, miR-133a, miR-141 and miR-19a, was significantly altered in the PDLSCs cultured with ibandronate.
tissue_expression_ns	hsa-mir-19a	Bone Disease [unspecific]	21108928	musculoskeletal system disease	DOID:0080001	M89.9	D001847			The expression of miRNAs, including miR-18a, miR-133a, miR-141 and miR-19a, was significantly altered in the PDLSCs cultured with ibandronate.
tissue_expression_ns	hsa-mir-1244	Borna Disease	27748825	disease by infectious agent	DOID:5154		D001890			Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus.
tissue_expression_ns	hsa-mir-1290	Borna Disease	27748825	disease by infectious agent	DOID:5154		D001890			Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus.
tissue_expression_ns	hsa-mir-146a	Borna Disease	27748825	disease by infectious agent	DOID:5154		D001890			Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus.
tissue_expression_ns	hsa-mir-1908	Borna Disease	27748825	disease by infectious agent	DOID:5154		D001890			Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus.
tissue_expression_ns	hsa-mir-296	Borna Disease	27748825	disease by infectious agent	DOID:5154		D001890			Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus.
tissue_expression_ns	hsa-mir-3676	Borna Disease	27748825	disease by infectious agent	DOID:5154		D001890			Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus.
tissue_expression_ns	hsa-mir-424	Borna Disease	27748825	disease by infectious agent	DOID:5154		D001890			Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus.
tissue_expression_ns	hsa-mir-4521	Borna Disease	27748825	disease by infectious agent	DOID:5154		D001890			Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus.
tissue_expression_ns	hsa-mir-7	Borna Disease	27748825	disease by infectious agent	DOID:5154		D001890			Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus.
tissue_expression_ns	hsa-mir-129-1	Brain Neoplasms	21157891	disease of cellular proliferation	DOID:1319	C71	D001932	603688	HP:0030692	MicroRNA-129, miR-142-5p, and miR-25 were differ entially expressed in every pediatric brain tumor type compared to normal tissue controls as measured by microarray.
tissue_expression_ns	hsa-mir-129-2	Brain Neoplasms	21157891	disease of cellular proliferation	DOID:1319	C71	D001932	603688	HP:0030692	MicroRNA-129, miR-142-5p, and miR-25 were differ entially expressed in every pediatric brain tumor type compared to normal tissue controls as measured by microarray.
tissue_expression_ns	hsa-mir-9-1	Brain Neoplasms	18624795	disease of cellular proliferation	DOID:1319	C71	D001932	603688	HP:0030692	miR-9: Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors
tissue_expression_ns	hsa-mir-9-2	Brain Neoplasms	18624795	disease of cellular proliferation	DOID:1319	C71	D001932	603688	HP:0030692	miR-9: Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors
tissue_expression_ns	hsa-mir-92b	Brain Neoplasms	18624795	disease of cellular proliferation	DOID:1319	C71	D001932	603688	HP:0030692	miR-92b: Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors
tissue_expression_ns	hsa-mir-9-3	Brain Neoplasms	18624795	disease of cellular proliferation	DOID:1319	C71	D001932	603688	HP:0030692	miR-9: Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors
tissue_expression_ns	hsa-mir-16	Breast Adenocarcinoma	20433153	thoracic disease	DOID:3458					Using isolated total RNA from human breast adenocarcinoma MCF-7 cells, the assay detected specifically miR-21 and miR-16 in parallel, and higher expression of oncogene miR-21 compared to miR-16 was demonstrated.
tissue_expression_ns	hsa-mir-21	Breast Adenocarcinoma	20433153	thoracic disease	DOID:3458					Using isolated total RNA from human breast adenocarcinoma MCF-7 cells, the assay detected specifically miR-21 and miR-16 in parallel, and higher expression of oncogene miR-21 compared to miR-16 was demonstrated.
tissue_expression_ns	hsa-let-7a	Breast Neoplasms	26130254	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer.
tissue_expression_ns	hsa-let-7b	Breast Neoplasms	22294324	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let-7b expression was shown to be associated with luminal tumours, and to have an independent significant positive prognostic value in this group. miR-205 is associated with tumours of ductal morphology, and is of significant positive prognostic value within these tumours.
tissue_expression_ns	hsa-let-7b	Breast Neoplasms	22976804	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	By means of RT-qPCR, we further investigated miRNA expression in more IMPC (n = 22) and IDC-NSTs (n = 24) FFPE samples and found let-7b, miR-30c, miR-148a, miR-181a, miR-181a*, and miR-181b were significantly differently expressed between the two groups. 
tissue_expression_ns	hsa-let-7c	Breast Neoplasms	26982264	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	we identified seven miRNAs (miR-9-5p, miR-9-3p, let-7c, miR-127-3p, miR-99a-5p, miR-129-5p, and miR-146a-5p) that were deregulated as a consequence of claudin 1 overexpression in the MDA-MB231 human breast cancer (HBC) cell line.
tissue_expression_ns	hsa-let-7i	Breast Neoplasms	22315424	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Five noncoding genes were associated with both prognostic signatures-miR-210, -21, -106b*, -197, and let-7i, with miR-210 the only one also involved in the invasive transition.
tissue_expression_ns	hsa-mir-1	Breast Neoplasms	23797906	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The clinical use of miRNA signatures as a noninvasive diagnostic strategy is promising, but should be further validated for different subtypes of breast cancers.
tissue_expression_ns	hsa-mir-106b	Breast Neoplasms	26684238	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Taken together, we have for the first time characterized the BMP4-induced miRNA expression profiles in breast cancer cell lines, showing that induced miRNAs contribute to the fine-tuning of proliferation and migration phenotypes.
tissue_expression_ns	hsa-mir-106b	Breast Neoplasms	22315424	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Five noncoding genes were associated with both prognostic signatures-miR-210, -21, -106b*, -197, and let-7i, with miR-210 the only one also involved in the invasive transition.
tissue_expression_ns	hsa-mir-10a	Breast Neoplasms	24632820	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	In summary, we have identified a set of recurrence-related microRNAs with potential prognostic value to identify patients who will likely develop metastasis early after primary breast surgery.
tissue_expression_ns	hsa-mir-10a	Breast Neoplasms	20099276	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-10a:dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c
tissue_expression_ns	hsa-mir-10a	Breast Neoplasms	21955614	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.
tissue_expression_ns	hsa-mir-10a	Breast Neoplasms	27433802	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified eight microRNAs (miR-10a, miR-10b, miR-21, miR-124, miR-125b, miR-126, miR-145 and miR-200a) to be associated with DMBA-induced mammary tumor progression.
tissue_expression_ns	hsa-mir-10b	Breast Neoplasms	24196612	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	microRNA expression in breast development and breast cancer]
tissue_expression_ns	hsa-mir-10b	Breast Neoplasms	24440078	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Detection of miRNA expression in intact cells using activatable sensor oligonucleotides.
tissue_expression_ns	hsa-mir-10b	Breast Neoplasms	24440980	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiR-21, -155, -222 and -10b are reliable candidate biomarkers for detection of breast cancer.
tissue_expression_ns	hsa-mir-10b	Breast Neoplasms	27433802	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified eight microRNAs (miR-10a, miR-10b, miR-21, miR-124, miR-125b, miR-126, miR-145 and miR-200a) to be associated with DMBA-induced mammary tumor progression.
tissue_expression_ns	hsa-mir-10b	Breast Neoplasms	28101798	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-10b, miR-26a, miR-146a And miR-153 Expression in Triple Negative Vs Non Triple Negative Breast Cancer: Potential Biomarkers.
tissue_expression_ns	hsa-mir-10b	Breast Neoplasms	29113216	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-10b is a useful marker for predicting metastasis and angiogenesis in ANN breast cancer
tissue_expression_ns	hsa-mir-124	Breast Neoplasms	27433802	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified eight microRNAs (miR-10a, miR-10b, miR-21, miR-124, miR-125b, miR-126, miR-145 and miR-200a) to be associated with DMBA-induced mammary tumor progression.
tissue_expression_ns	hsa-mir-1248	Breast Neoplasms	24917463	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	we identified miRNA expression signatures predictive of BRCA1/2 mutation status in routinely available FFPE breast tumor samples, which may be useful to complement current patient selection criteria for gene testing by identifying individuals with high likelihood of being BRCA1/2 mutation carriers.
tissue_expression_ns	hsa-mir-124a	Breast Neoplasms	26897751	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiR-124a and miR-30d were correlated with insulin resistance and development of BC with T2DM.
tissue_expression_ns	hsa-mir-125b	Breast Neoplasms	25886191	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a  specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection.
tissue_expression_ns	hsa-mir-125b	Breast Neoplasms	27433802	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified eight microRNAs (miR-10a, miR-10b, miR-21, miR-124, miR-125b, miR-126, miR-145 and miR-200a) to be associated with DMBA-induced mammary tumor progression.
tissue_expression_ns	hsa-mir-125b	Breast Neoplasms	29483949	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differentially expressed miRNAs provide insights of this uncommon but highly aggressive pathology
tissue_expression_ns	hsa-mir-125b-1	Breast Neoplasms	21375733	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	dysregulated
tissue_expression_ns	hsa-mir-125b-1	Breast Neoplasms	21955614	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.
tissue_expression_ns	hsa-mir-125b-2	Breast Neoplasms	21375733	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	dysregulated
tissue_expression_ns	hsa-mir-125b-2	Breast Neoplasms	21955614	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.
tissue_expression_ns	hsa-mir-126	Breast Neoplasms	27433802	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified eight microRNAs (miR-10a, miR-10b, miR-21, miR-124, miR-125b, miR-126, miR-145 and miR-200a) to be associated with DMBA-induced mammary tumor progression.
tissue_expression_ns	hsa-mir-127	Breast Neoplasms	26982264	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	we identified seven miRNAs (miR-9-5p, miR-9-3p, let-7c, miR-127-3p, miR-99a-5p, miR-129-5p, and miR-146a-5p) that were deregulated as a consequence of claudin 1 overexpression in the MDA-MB231 human breast cancer (HBC) cell line.
tissue_expression_ns	hsa-mir-129	Breast Neoplasms	26982264	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	we identified seven miRNAs (miR-9-5p, miR-9-3p, let-7c, miR-127-3p, miR-99a-5p, miR-129-5p, and miR-146a-5p) that were deregulated as a consequence of claudin 1 overexpression in the MDA-MB231 human breast cancer (HBC) cell line.
tissue_expression_ns	hsa-mir-130b	Breast Neoplasms	26152113	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Comparative microRNA profiling of sporadic and BRCA1 associated basal-like breast cancers
tissue_expression_ns	hsa-mir-133a	Breast Neoplasms	23797906	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The clinical use of miRNA signatures as a noninvasive diagnostic strategy is promising, but should be further validated for different subtypes of breast cancers.
tissue_expression_ns	hsa-mir-133b	Breast Neoplasms	23797906	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The clinical use of miRNA signatures as a noninvasive diagnostic strategy is promising, but should be further validated for different subtypes of breast cancers.
tissue_expression_ns	hsa-mir-139	Breast Neoplasms	27082076	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNAs  included in the invasive signatures include downregulation of miR-139-5p in aggressive subtypes and upregulation of miR-29c-5p expression in the luminal subtypes.
tissue_expression_ns	hsa-mir-142	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-142	Breast Neoplasms	24917463	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	we identified miRNA expression signatures predictive of BRCA1/2 mutation status in routinely available FFPE breast tumor samples, which may be useful to complement current patient selection criteria for gene testing by identifying individuals with high likelihood of being BRCA1/2 mutation carriers.
tissue_expression_ns	hsa-mir-143	Breast Neoplasms	29073169	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Expression and function of the miR-143/145 cluster in vitro and in vivo in human breast cancer.
tissue_expression_ns	hsa-mir-145	Breast Neoplasms	27433802	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified eight microRNAs (miR-10a, miR-10b, miR-21, miR-124, miR-125b, miR-126, miR-145 and miR-200a) to be associated with DMBA-induced mammary tumor progression.
tissue_expression_ns	hsa-mir-145	Breast Neoplasms	29073169	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Expression and function of the miR-143/145 cluster in vitro and in vivo in human breast cancer.
tissue_expression_ns	hsa-mir-146a	Breast Neoplasms	20099276	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-146a:dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c
tissue_expression_ns	hsa-mir-146a	Breast Neoplasms	26982264	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	we identified seven miRNAs (miR-9-5p, miR-9-3p, let-7c, miR-127-3p, miR-99a-5p, miR-129-5p, and miR-146a-5p) that were deregulated as a consequence of claudin 1 overexpression in the MDA-MB231 human breast cancer (HBC) cell line.
tissue_expression_ns	hsa-mir-146a	Breast Neoplasms	28101798	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-10b, miR-26a, miR-146a And miR-153 Expression in Triple Negative Vs Non Triple Negative Breast Cancer: Potential Biomarkers.
tissue_expression_ns	hsa-mir-148a	Breast Neoplasms	26199650	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Based on the results obtained in the last decade, some miRNAs are emerging as biomarkers of BC for diagnosis (i.e., miR-9, miR-10b, and miR-17-5p), prognosis (i.e., miR-148a and miR-335)
tissue_expression_ns	hsa-mir-148a	Breast Neoplasms	22976804	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	By means of RT-qPCR, we further investigated miRNA expression in more IMPC (n = 22) and IDC-NSTs (n = 24) FFPE samples and found let-7b, miR-30c, miR-148a, miR-181a, miR-181a*, and miR-181b were significantly differently expressed between the two groups. 
tissue_expression_ns	hsa-mir-149	Breast Neoplasms	24632820	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	In summary, we have identified a set of recurrence-related microRNAs with potential prognostic value to identify patients who will likely develop metastasis early after primary breast surgery.
tissue_expression_ns	hsa-mir-149	Breast Neoplasms	26152113	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Comparative microRNA profiling of sporadic and BRCA2 associated basal-like breast cancers
tissue_expression_ns	hsa-mir-151	Breast Neoplasms	25339470	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Specific differentially expressed miRNAs of the three subtypes were identified, including hsa-miR-99a and hsa-miR-151-3p for DCIS breast cancer, hsa-miR-145 and hsa-miR-210 for invasive breast cancer, and has-miR-205 and has-miR-361-5p metastatic breast cancer.
tissue_expression_ns	hsa-mir-152	Breast Neoplasms	25393370	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	For the first time, a different microRNA expression pattern in male and female fBC has been shown. Moreover, the importance of RASSF1A pathway in male fBC carcinogenesis has been confirmed, highlighting a possible role for miR-152 and miR-497 in controlling MAPK and Hippo signalling pathways, regulated by RASSF1A.
tissue_expression_ns	hsa-mir-153	Breast Neoplasms	28101798	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-10b, miR-26a, miR-146a And miR-153 Expression in Triple Negative Vs Non Triple Negative Breast Cancer: Potential Biomarkers.
tissue_expression_ns	hsa-mir-155	Breast Neoplasms	24440980	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiR-21, -155, -222 and -10b are reliable candidate biomarkers for detection of breast cancer.
tissue_expression_ns	hsa-mir-155	Breast Neoplasms	25157366	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiR-155 detection might have a diagnostic value in breast cancer patients. It might be used as an auxiliary biomarker for different clinicopathological breast cancer.
tissue_expression_ns	hsa-mir-155	Breast Neoplasms	25886191	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a  specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection.
tissue_expression_ns	hsa-mir-155	Breast Neoplasms	20664596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-155:miR-155, is differentially expressed in ER- versus ER+ tumors
tissue_expression_ns	hsa-mir-155	Breast Neoplasms	23162645	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-155 and miR-31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status
tissue_expression_ns	hsa-mir-155	Breast Neoplasms	28882698	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Prognostic value of microRNA-9 and microRNA-155 expression in triple-negative breast cancer
tissue_expression_ns	hsa-mir-15a	Breast Neoplasms	25550542	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiR-15a expression levels could be a promising biological and prognostic marker for overall survival especially in triple-negative BC cases.
tissue_expression_ns	hsa-mir-16	Breast Neoplasms	26684238	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Taken together, we have for the first time characterized the BMP4-induced miRNA expression profiles in breast cancer cell lines, showing that induced miRNAs contribute to the fine-tuning of proliferation and migration phenotypes.
tissue_expression_ns	hsa-mir-17	Breast Neoplasms	24626680	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MicroRNA expression profiles in human breast cancer cells after multifraction and single-dose radiation treatment.
tissue_expression_ns	hsa-mir-181a	Breast Neoplasms	22976804	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	By means of RT-qPCR, we further investigated miRNA expression in more IMPC (n = 22) and IDC-NSTs (n = 24) FFPE samples and found let-7b, miR-30c, miR-148a, miR-181a, miR-181a*, and miR-181b were significantly differently expressed between the two groups. 
tissue_expression_ns	hsa-mir-181a-2	Breast Neoplasms	21955614	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.
tissue_expression_ns	hsa-mir-181a-2	Breast Neoplasms	24917463	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	we identified miRNA expression signatures predictive of BRCA1/2 mutation status in routinely available FFPE breast tumor samples, which may be useful to complement current patient selection criteria for gene testing by identifying individuals with high likelihood of being BRCA1/2 mutation carriers.
tissue_expression_ns	hsa-mir-181b	Breast Neoplasms	22976804	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	By means of RT-qPCR, we further investigated miRNA expression in more IMPC (n = 22) and IDC-NSTs (n = 24) FFPE samples and found let-7b, miR-30c, miR-148a, miR-181a, miR-181a*, and miR-181b were significantly differently expressed between the two groups. 
tissue_expression_ns	hsa-mir-181b-1	Breast Neoplasms	21955614	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.
tissue_expression_ns	hsa-mir-181b-2	Breast Neoplasms	21955614	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.
tissue_expression_ns	hsa-mir-182	Breast Neoplasms	21375733	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	dysregulated
tissue_expression_ns	hsa-mir-183	Breast Neoplasms	21375733	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	dysregulated
tissue_expression_ns	hsa-mir-185	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-18a	Breast Neoplasms	24626680	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MicroRNA expression profiles in human breast cancer cells after multifraction and single-dose radiation treatment.
tissue_expression_ns	hsa-mir-190b	Breast Neoplasms	26152113	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Comparative microRNA profiling of sporadic and BRCA3 associated basal-like breast cancers
tissue_expression_ns	hsa-mir-191	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-195	Breast Neoplasms	25886191	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a  specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection.
tissue_expression_ns	hsa-mir-195	Breast Neoplasms	21375733	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	dysregulated
tissue_expression_ns	hsa-mir-196a	Breast Neoplasms	21962133	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-196a has been reported to be aberrantly expressed in breast cancer tissue. 
tissue_expression_ns	hsa-mir-197	Breast Neoplasms	22315424	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Five noncoding genes were associated with both prognostic signatures-miR-210, -21, -106b*, -197, and let-7i, with miR-210 the only one also involved in the invasive transition.
tissue_expression_ns	hsa-mir-198	Breast Neoplasms	26152113	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Comparative microRNA profiling of sporadic and BRCA4 associated basal-like breast cancers
tissue_expression_ns	hsa-mir-19a	Breast Neoplasms	24626680	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MicroRNA expression profiles in human breast cancer cells after multifraction and single-dose radiation treatment.
tissue_expression_ns	hsa-mir-19b	Breast Neoplasms	24626680	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MicroRNA expression profiles in human breast cancer cells after multifraction and single-dose radiation treatment.
tissue_expression_ns	hsa-mir-200a	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-200a	Breast Neoplasms	21955614	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.
tissue_expression_ns	hsa-mir-200b	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-200b	Breast Neoplasms	25886191	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a  specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection.
tissue_expression_ns	hsa-mir-200b	Breast Neoplasms	20099276	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-200b:dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c
tissue_expression_ns	hsa-mir-200b	Breast Neoplasms	21955614	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.
tissue_expression_ns	hsa-mir-200c	Breast Neoplasms	25886191	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a  specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection.
tissue_expression_ns	hsa-mir-200c	Breast Neoplasms	20099276	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-200c:dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c
tissue_expression_ns	hsa-mir-200c	Breast Neoplasms	21955614	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.
tissue_expression_ns	hsa-mir-204	Breast Neoplasms	25031750	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	the miR-204 may be a potential diagnostic and prognostic biomarker of breast cancer.
tissue_expression_ns	hsa-mir-204	Breast Neoplasms	24191129	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The expression and the functional role of several miRNAs (miR-206, miR-31, miR-27a/b, miR-21, miR-92a, miR-205, miR-125a/b, miR-10b, miR-155, miR-146a/b, miR-335, miR-204, miR-211, miR-7, miR-22, miR-126, and miR-17) in breast cancer has been identified.
tissue_expression_ns	hsa-mir-205	Breast Neoplasms	21955614	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.
tissue_expression_ns	hsa-mir-205	Breast Neoplasms	22294324	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let-7b expression was shown to be associated with luminal tumours, and to have an independent significant positive prognostic value in this group. miR-205 is associated with tumours of ductal morphology, and is of significant positive prognostic value within these tumours.
tissue_expression_ns	hsa-mir-205	Breast Neoplasms	22631664	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-205 and miR-342 may be used as potential biomarkers for diagnosis of triple negative breast cancer.
tissue_expression_ns	hsa-mir-206	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-20a	Breast Neoplasms	24626680	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MicroRNA expression profiles in human breast cancer cells after multifraction and single-dose radiation treatment.
tissue_expression_ns	hsa-mir-20b	Breast Neoplasms	24632820	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	In summary, we have identified a set of recurrence-related microRNAs with potential prognostic value to identify patients who will likely develop metastasis early after primary breast surgery.
tissue_expression_ns	hsa-mir-21	Breast Neoplasms	24440980	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiR-21, -155, -222 and -10b are reliable candidate biomarkers for detection of breast cancer.
tissue_expression_ns	hsa-mir-21	Breast Neoplasms	25886191	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a  specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection.
tissue_expression_ns	hsa-mir-21	Breast Neoplasms	21955614	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.
tissue_expression_ns	hsa-mir-21	Breast Neoplasms	22315424	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Five noncoding genes were associated with both prognostic signatures-miR-210, -21, -106b*, -197, and let-7i, with miR-210 the only one also involved in the invasive transition.
tissue_expression_ns	hsa-mir-21	Breast Neoplasms	26891730	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Analysis has shown that changes in miR-21 levels might be important for the later and/or late phases of breast cancerogenesis rather than for the initial early phases.
tissue_expression_ns	hsa-mir-21	Breast Neoplasms	27433802	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified eight microRNAs (miR-10a, miR-10b, miR-21, miR-124, miR-125b, miR-126, miR-145 and miR-200a) to be associated with DMBA-induced mammary tumor progression.
tissue_expression_ns	hsa-mir-210	Breast Neoplasms	24196612	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	microRNA expression in breast development and breast cancer]
tissue_expression_ns	hsa-mir-215	Breast Neoplasms	25270284	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Aberrant miR-215 expression is associated with clinical outcome in breast cancer patients.
tissue_expression_ns	hsa-mir-218	Breast Neoplasms	26152113	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Comparative microRNA profiling of sporadic and BRCA5 associated basal-like breast cancers
tissue_expression_ns	hsa-mir-22	Breast Neoplasms	21955614	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.
tissue_expression_ns	hsa-mir-221	Breast Neoplasms	20099276	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-221:dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c
tissue_expression_ns	hsa-mir-221	Breast Neoplasms	27488105	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	An increase in miR-221/222 might be an important event for in situ carcinoma formation, and miR-221/222 may be important molecules that highlight potential differences between invasive breast carcinomas associated with non-invasive and pure invasive BCs.
tissue_expression_ns	hsa-mir-222	Breast Neoplasms	24440980	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiR-21, -155, -222 and -10b are reliable candidate biomarkers for detection of breast cancer.
tissue_expression_ns	hsa-mir-222	Breast Neoplasms	20099276	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-222:dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c
tissue_expression_ns	hsa-mir-222	Breast Neoplasms	21955614	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells
tissue_expression_ns	hsa-mir-222	Breast Neoplasms	27488105	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	An increase in miR-221/222 might be an important event for in situ carcinoma formation, and miR-221/222 may be important molecules that highlight potential differences between invasive breast carcinomas associated with non-invasive and pure invasive BCs.
tissue_expression_ns	hsa-mir-222	Breast Neoplasms	27659519	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Profiles of miRNAs matched to biology in aromatase inhibitor resistant breast cancer.
tissue_expression_ns	hsa-mir-23a	Breast Neoplasms	26684238	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Taken together, we have for the first time characterized the BMP4-induced miRNA expression profiles in breast cancer cell lines, showing that induced miRNAs contribute to the fine-tuning of proliferation and migration phenotypes.
tissue_expression_ns	hsa-mir-23b	Breast Neoplasms	26684238	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Taken together, we have for the first time characterized the BMP4-induced miRNA expression profiles in breast cancer cell lines, showing that induced miRNAs contribute to the fine-tuning of proliferation and migration phenotypes.
tissue_expression_ns	hsa-mir-25	Breast Neoplasms	24917463	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	we identified miRNA expression signatures predictive of BRCA1/2 mutation status in routinely available FFPE breast tumor samples, which may be useful to complement current patient selection criteria for gene testing by identifying individuals with high likelihood of being BRCA1/2 mutation carriers.
tissue_expression_ns	hsa-mir-26a	Breast Neoplasms	28101798	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-10b, miR-26a, miR-146a And miR-153 Expression in Triple Negative Vs Non Triple Negative Breast Cancer: Potential Biomarkers.
tissue_expression_ns	hsa-mir-29a	Breast Neoplasms	20664596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-29a:We identified a set of 13 miRNAs of which expression differed between IBC and non-IBC, making these miRNAs candidate markers for the IBC subtype
tissue_expression_ns	hsa-mir-29a	Breast Neoplasms	21955614	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.
tissue_expression_ns	hsa-mir-29b	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-29c	Breast Neoplasms	27082076	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	include downregulation of miR-139-5p in aggressive subtypes and upregulation of miR-29c-5p expression in the luminal subtypes.
tissue_expression_ns	hsa-mir-30a	Breast Neoplasms	24632820	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	In summary, we have identified a set of recurrence-related microRNAs with potential prognostic value to identify patients who will likely develop metastasis early after primary breast surgery.
tissue_expression_ns	hsa-mir-30b	Breast Neoplasms	20664596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-30b:We identified a set of 13 miRNAs of which expression differed between IBC and non-IBC, making these miRNAs candidate markers for the IBC subtype
tissue_expression_ns	hsa-mir-30c	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-30c	Breast Neoplasms	22976804	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	By means of RT-qPCR, we further investigated miRNA expression in more IMPC (n = 22) and IDC-NSTs (n = 24) FFPE samples and found let-7b, miR-30c, miR-148a, miR-181a, miR-181a*, and miR-181b were significantly differently expressed between the two groups. 
tissue_expression_ns	hsa-mir-30d	Breast Neoplasms	26897751	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiR-124a and miR-30d were correlated with insulin resistance and development of BC with T2DM.
tissue_expression_ns	hsa-mir-31	Breast Neoplasms	24196612	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	microRNA expression in breast development and breast cancer]
tissue_expression_ns	hsa-mir-31	Breast Neoplasms	23162645	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-155 and miR-31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status
tissue_expression_ns	hsa-mir-31	Breast Neoplasms	27659519	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Profiles of miRNAs matched to biology in aromatase inhibitor resistant breast cancer.
tissue_expression_ns	hsa-mir-3196	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-335	Breast Neoplasms	24196612	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	microRNA expression in breast development and breast cancer]
tissue_expression_ns	hsa-mir-339	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-340	Breast Neoplasms	24917463	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	we identified miRNA expression signatures predictive of BRCA1/2 mutation status in routinely available FFPE breast tumor samples, which may be useful to complement current patient selection criteria for gene testing by identifying individuals with high likelihood of being BRCA1/2 mutation carriers.
tissue_expression_ns	hsa-mir-342	Breast Neoplasms	24632820	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	In summary, we have identified a set of recurrence-related microRNAs with potential prognostic value to identify patients who will likely develop metastasis early after primary breast surgery.
tissue_expression_ns	hsa-mir-342	Breast Neoplasms	20664596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-342-3p:We identified a set of 13 miRNAs of which expression differed between IBC and non-IBC, making these miRNAs candidate markers for the IBC subtype
tissue_expression_ns	hsa-mir-342	Breast Neoplasms	22631664	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-205 and miR-342 may be used as potential biomarkers for diagnosis of triple negative breast cancer.
tissue_expression_ns	hsa-mir-345	Breast Neoplasms	20099276	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-345:dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c
tissue_expression_ns	hsa-mir-34a	Breast Neoplasms	25886191	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a  specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection.
tissue_expression_ns	hsa-mir-374b	Breast Neoplasms	26152113	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Comparative microRNA profiling of sporadic and BRCA7 associated basal-like breast cancers
tissue_expression_ns	hsa-mir-375	Breast Neoplasms	25886191	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a  specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection.
tissue_expression_ns	hsa-mir-3923	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-421	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-451	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-451	Breast Neoplasms	25886191	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a  specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection.
tissue_expression_ns	hsa-mir-497	Breast Neoplasms	25393370	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	For the first time, a different microRNA expression pattern in male and female fBC has been shown. Moreover, the importance of RASSF1A pathway in male fBC carcinogenesis has been confirmed, highlighting a possible role for miR-152 and miR-497 in controlling MAPK and Hippo signalling pathways, regulated by RASSF1A.
tissue_expression_ns	hsa-mir-503	Breast Neoplasms	29164842	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-503 is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma andseveral others
tissue_expression_ns	hsa-mir-505	Breast Neoplasms	24917463	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	we identified miRNA expression signatures predictive of BRCA1/2 mutation status in routinely available FFPE breast tumor samples, which may be useful to complement current patient selection criteria for gene testing by identifying individuals with high likelihood of being BRCA1/2 mutation carriers.
tissue_expression_ns	hsa-mir-520a	Breast Neoplasms	20664596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-520a-5p:We identified a set of 13 miRNAs of which expression differed between IBC and non-IBC, making these miRNAs candidate markers for the IBC subtype
tissue_expression_ns	hsa-mir-542	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-564	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-590	Breast Neoplasms	26152113	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Comparative microRNA profiling of sporadic and BRCA6 associated basal-like breast cancers
tissue_expression_ns	hsa-mir-892a	Breast Neoplasms	26152113	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Comparative microRNA profiling of sporadic and BRCA8 associated basal-like breast cancers
tissue_expression_ns	hsa-mir-9	Breast Neoplasms	26982264	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	we identified seven miRNAs (miR-9-5p, miR-9-3p, let-7c, miR-127-3p, miR-99a-5p, miR-129-5p, and miR-146a-5p) that were deregulated as a consequence of claudin 1 overexpression in the MDA-MB231 human breast cancer (HBC) cell line.
tissue_expression_ns	hsa-mir-9	Breast Neoplasms	28882698	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Prognostic value of microRNA-9 and microRNA-155 expression in triple-negative breast cancer
tissue_expression_ns	hsa-mir-92a	Breast Neoplasms	24626680	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MicroRNA expression profiles in human breast cancer cells after multifraction and single-dose radiation treatment.
tissue_expression_ns	hsa-mir-92a	Breast Neoplasms	24846313	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features.
tissue_expression_ns	hsa-mir-92a	Breast Neoplasms	23797906	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The clinical use of miRNA signatures as a noninvasive diagnostic strategy is promising, but should be further validated for different subtypes of breast cancers.
tissue_expression_ns	hsa-mir-93	Breast Neoplasms	21955614	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.
tissue_expression_ns	hsa-mir-99a	Breast Neoplasms	26982264	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	we identified seven miRNAs (miR-9-5p, miR-9-3p, let-7c, miR-127-3p, miR-99a-5p, miR-129-5p, and miR-146a-5p) that were deregulated as a consequence of claudin 1 overexpression in the MDA-MB231 human breast cancer (HBC) cell line.
tissue_expression_ns	hsa-let-7f	Bronchopulmonary Dysplasia	24301780			P27.1	D001997			MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis.
tissue_expression_ns	hsa-mir-130b	Bronchopulmonary Dysplasia	24301780			P27.1	D001997			MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis.
tissue_expression_ns	hsa-mir-141	Bronchopulmonary Dysplasia	24301780			P27.1	D001997			MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis.
tissue_expression_ns	hsa-mir-146b	Bronchopulmonary Dysplasia	24301780			P27.1	D001997			MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis.
tissue_expression_ns	hsa-mir-150	Bronchopulmonary Dysplasia	27216745			P27.1	D001997			expression of miR-150 was altered in experimental BPD
tissue_expression_ns	hsa-mir-21	Bronchopulmonary Dysplasia	24301780			P27.1	D001997			MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis.
tissue_expression_ns	hsa-mir-214	Bronchopulmonary Dysplasia	24301780			P27.1	D001997			MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis.
tissue_expression_ns	hsa-mir-29a	Bronchopulmonary Dysplasia	24301780			P27.1	D001997			MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis.
tissue_expression_ns	hsa-mir-34a	Bronchopulmonary Dysplasia	24301780			P27.1	D001997			MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis.
tissue_expression_ns	hsa-mir-382	Bronchopulmonary Dysplasia	24301780			P27.1	D001997			MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis.
tissue_expression_ns	hsa-mir-411	Bronchopulmonary Dysplasia	24301780			P27.1	D001997			MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis.
tissue_expression_ns	hsa-mir-431	Bronchopulmonary Dysplasia	24301780			P27.1	D001997			MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis.
tissue_expression_ns	hsa-mir-503	Bronchopulmonary Dysplasia	24301780			P27.1	D001997			MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis.
tissue_expression_ns	hsa-mir-150	Burns	28404517			M61.30	D002056			Dysregulation of microRNA biogenesis in the small intestine after ethanol and burn injury.
tissue_expression_ns	hsa-mir-23b	Carcinoma, Adenoid Cystic	25240490	disease of cellular proliferation	DOID:0080202		D003528			9 microRNAs were downexpressed in sACC cases and overexpressed in bACC tissues (let-7e, miR-23b, miR-27b, miR-193b, miR-320a, miR-320c, miR-768-5p, miR-1280 and miR-1826) relative to their controls.
tissue_expression_ns	hsa-mir-23b	Carcinoma, Adenoid Cystic	26293217	disease of cellular proliferation	DOID:0080202		D003528			Expression of miR-23b and  miR-27b differed between normal breast and normal salivary gland tissue
tissue_expression_ns	hsa-mir-195	Carcinoma, Adrenocortical	24890943	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	In conclusion, (a) miR-483-3p, miR-483-5p, and miR-210 are differentially expressed in ACC variants, and (b) high miR-210 is associated with clinicopathologic parameters of aggressiveness and a poor prognosis.
tissue_expression_ns	hsa-mir-1974	Carcinoma, Adrenocortical	24890943	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	In conclusion, (a) miR-483-3p, miR-483-5p, and miR-210 are differentially expressed in ACC variants, and (b) high miR-210 is associated with clinicopathologic parameters of aggressiveness and a poor prognosis.
tissue_expression_ns	hsa-mir-210	Carcinoma, Adrenocortical	24890943	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	In conclusion, (a) miR-483-3p, miR-483-5p, and miR-210 are differentially expressed in ACC variants, and (b) high miR-210 is associated with clinicopathologic parameters of aggressiveness and a poor prognosis.
tissue_expression_ns	hsa-mir-483	Carcinoma, Adrenocortical	24890943	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	In conclusion, (a) miR-483-3p, miR-483-5p, and miR-210 are differentially expressed in ACC variants, and (b) high miR-210 is associated with clinicopathologic parameters of aggressiveness and a poor prognosis.
tissue_expression_ns	hsa-let-7c	Carcinoma, Bladder	25990459	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	this study identified the specific miRNAs associated with the progression and aggressiveness of MIBC and a four-miRNA signature as a promising prognostic parameter of MIBC.
tissue_expression_ns	hsa-mir-100	Carcinoma, Bladder	27586262	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	microRNA expression profiles as decision-making biomarkers in the management of bladder cancer.
tissue_expression_ns	hsa-mir-100	Carcinoma, Bladder	27631180	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	Evaluation of miR-182/miR-100 Ratio for Diagnosis and Survival Prediction in Bladder Cancer.
tissue_expression_ns	hsa-mir-125b-1	Carcinoma, Bladder	25990459	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	this study identified the specific miRNAs associated with the progression and aggressiveness of MIBC and a four-miRNA signature as a promising prognostic parameter of MIBC.
tissue_expression_ns	hsa-mir-146a	Carcinoma, Bladder	27751843	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	Real-time PCR analysis pointed to miR-375 as a biomarker for high-grade bladder cancer while miR-146a could identify low-grade patients
tissue_expression_ns	hsa-mir-146b	Carcinoma, Bladder	27586262	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	microRNA expression profiles as decision-making biomarkers in the management of bladder cancer.
tissue_expression_ns	hsa-mir-182	Carcinoma, Bladder	27631180	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	Evaluation of miR-182/miR-100 Ratio for Diagnosis and Survival Prediction in Bladder Cancer.
tissue_expression_ns	hsa-mir-193a	Carcinoma, Bladder	25990459	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	this study identified the specific miRNAs associated with the progression and aggressiveness of MIBC and a four-miRNA signature as a promising prognostic parameter of MIBC.
tissue_expression_ns	hsa-mir-193a	Carcinoma, Bladder	27586262	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	microRNA expression profiles as decision-making biomarkers in the management of bladder cancer.
tissue_expression_ns	hsa-mir-34	Carcinoma, Bladder	27586262	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	microRNA expression profiles as decision-making biomarkers in the management of bladder cancer.
tissue_expression_ns	hsa-mir-375	Carcinoma, Bladder	27751843	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	Real-time PCR analysis pointed to miR-375 as a biomarker for high-grade bladder cancer while miR-146a could identify low-grade patients
tissue_expression_ns	hsa-mir-9	Carcinoma, Bladder	27586262	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	microRNA expression profiles as decision-making biomarkers in the management of bladder cancer.
tissue_expression_ns	hsa-mir-99a	Carcinoma, Bladder	25990459	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	this study identified the specific miRNAs associated with the progression and aggressiveness of MIBC and a four-miRNA signature as a promising prognostic parameter of MIBC.
tissue_expression_ns	hsa-mir-1	Carcinoma, Breast	26331797			D05	D001943	114480	HP:0003002	These findings suggest that abnormal miR-1 expression is associated with an aggressive phenotype of breast carcinoma and that miR-1 status is a potent prognostic factor in human breast cancer patients.
tissue_expression_ns	hsa-mir-1246	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-1268a	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-1303	Carcinoma, Breast	23526361			D05	D001943	114480	HP:0003002	Among these, a 5-miRNA signature comprising miR-421, miR-486, miR-503, miR-720 and miR-1303 was shown to be predictive for IBC phenotype with an overall accuracy of 89%. 
tissue_expression_ns	hsa-mir-130a	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-138	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-139	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-197	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-200b	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-210	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-3613	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-421	Carcinoma, Breast	23526361			D05	D001943	114480	HP:0003002	Among these, a 5-miRNA signature comprising miR-421, miR-486, miR-503, miR-720 and miR-1303 was shown to be predictive for IBC phenotype with an overall accuracy of 89%. 
tissue_expression_ns	hsa-mir-4258	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-4298	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-449a	Carcinoma, Breast	27748845			D05	D001943	114480	HP:0003002	MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib.
tissue_expression_ns	hsa-mir-449b	Carcinoma, Breast	27748845			D05	D001943	114480	HP:0003002	MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib.
tissue_expression_ns	hsa-mir-452	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-4644	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-486	Carcinoma, Breast	23526361			D05	D001943	114480	HP:0003002	Among these, a 5-miRNA signature comprising miR-421, miR-486, miR-503, miR-720 and miR-1303 was shown to be predictive for IBC phenotype with an overall accuracy of 89%. 
tissue_expression_ns	hsa-mir-494	Carcinoma, Breast	27748845			D05	D001943	114480	HP:0003002	MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib.
tissue_expression_ns	hsa-mir-503	Carcinoma, Breast	23526361			D05	D001943	114480	HP:0003002	Among these, a 5-miRNA signature comprising miR-421, miR-486, miR-503, miR-720 and miR-1303 was shown to be predictive for IBC phenotype with an overall accuracy of 89%. 
tissue_expression_ns	hsa-mir-671	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-7107	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-720	Carcinoma, Breast	23526361			D05	D001943	114480	HP:0003002	Among these, a 5-miRNA signature comprising miR-421, miR-486, miR-503, miR-720 and miR-1303 was shown to be predictive for IBC phenotype with an overall accuracy of 89%. 
tissue_expression_ns	hsa-mir-7847	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-886	Carcinoma, Breast	27748845			D05	D001943	114480	HP:0003002	MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib.
tissue_expression_ns	hsa-mir-90b	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients
tissue_expression_ns	hsa-mir-923	Carcinoma, Breast	27748845			D05	D001943	114480	HP:0003002	MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib.
tissue_expression_ns	hsa-mir-126	Carcinoma, Breast, Triple Negative	26062749				D064726			This study provides strong evidence that the expression levels of miR-374b-5p, miR-27b-3p, miR-126-3p, and miR-218-5p in tumor tissues predict TNBC outcomes.
tissue_expression_ns	hsa-mir-155	Carcinoma, Breast, Triple Negative	24632568				D064726			microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers.
tissue_expression_ns	hsa-mir-17	Carcinoma, Breast, Triple Negative	24810926				D064726			Triple-negative and luminal A breast tumors: differential expression of miR-18a-5p, miR-17-5p, and miR-20a-5p.
tissue_expression_ns	hsa-mir-18a	Carcinoma, Breast, Triple Negative	24810926				D064726			Triple-negative and luminal A breast tumors: differential expression of miR-18a-5p, miR-17-5p, and miR-20a-5p.
tissue_expression_ns	hsa-mir-20a	Carcinoma, Breast, Triple Negative	24810926				D064726			Triple-negative and luminal A breast tumors: differential expression of miR-18a-5p, miR-17-5p, and miR-20a-5p.
tissue_expression_ns	hsa-mir-21	Carcinoma, Breast, Triple Negative	27113307				D064726			The function of MiR-21 expression differences and pathogenesis on familial and triple negative breast Cancer serum.
tissue_expression_ns	hsa-mir-218	Carcinoma, Breast, Triple Negative	26062749				D064726			This study provides strong evidence that the expression levels of miR-374b-5p, miR-27b-3p, miR-126-3p, and miR-218-5p in tumor tissues predict TNBC outcomes.
tissue_expression_ns	hsa-mir-27a	Carcinoma, Breast, Triple Negative	24632568				D064726			microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers.
tissue_expression_ns	hsa-mir-27b	Carcinoma, Breast, Triple Negative	26062749				D064726			This study provides strong evidence that the expression levels of miR-374b-5p, miR-27b-3p, miR-126-3p, and miR-218-5p in tumor tissues predict TNBC outcomes.
tissue_expression_ns	hsa-mir-30e	Carcinoma, Breast, Triple Negative	24632568				D064726			microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers.
tissue_expression_ns	hsa-mir-374b	Carcinoma, Breast, Triple Negative	26062749				D064726			This study provides strong evidence that the expression levels of miR-374b-5p, miR-27b-3p, miR-126-3p, and miR-218-5p in tumor tissues predict TNBC outcomes.
tissue_expression_ns	hsa-mir-493	Carcinoma, Breast, Triple Negative	24632568				D064726			microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers.
tissue_expression_ns	hsa-mir-106b	Carcinoma, Cervical	27764149	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China.
tissue_expression_ns	hsa-mir-10a	Carcinoma, Cervical	25920605	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers.
tissue_expression_ns	hsa-mir-141	Carcinoma, Cervical	25920605	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers.
tissue_expression_ns	hsa-mir-143	Carcinoma, Cervical	24517947	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	It seemed that miR-143 play an important role in the processes of generation and progression of cervical cancer. However, there was no significant difference found between the different ethnic groups. The expression level of miR-143 might serve as a valuable adjuvant parameter for diagnosing and predicting the state of cervical cancer.
tissue_expression_ns	hsa-mir-143	Carcinoma, Cervical	25920605	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers.
tissue_expression_ns	hsa-mir-145	Carcinoma, Cervical	25920605	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers.
tissue_expression_ns	hsa-mir-15a	Carcinoma, Cervical	27764149	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China.
tissue_expression_ns	hsa-mir-15b	Carcinoma, Cervical	25920605	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers.
tissue_expression_ns	hsa-mir-17	Carcinoma, Cervical	27764149	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China.
tissue_expression_ns	hsa-mir-200a	Carcinoma, Cervical	25920605	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers.
tissue_expression_ns	hsa-mir-203	Carcinoma, Cervical	25920605	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers.
tissue_expression_ns	hsa-mir-20a	Carcinoma, Cervical	25920605	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers.
tissue_expression_ns	hsa-mir-20a	Carcinoma, Cervical	27764149	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China.
tissue_expression_ns	hsa-mir-20b	Carcinoma, Cervical	25920605	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers.
tissue_expression_ns	hsa-mir-21	Carcinoma, Cervical	27764149	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China.
tissue_expression_ns	hsa-mir-215	Carcinoma, Cervical	24710934	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	It was concluded that the expression level of miR-215 is associated with cervical tumor progression and worse survival rate, suggesting that it may serve as a potential prognostic marker to identify patients at higher risk of recurrence.
tissue_expression_ns	hsa-mir-224	Carcinoma, Cervical	25920605	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers.
tissue_expression_ns	hsa-mir-3653	Carcinoma, Cervical	27764149	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China.
tissue_expression_ns	hsa-mir-497	Carcinoma, Cervical	27764149	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China.
tissue_expression_ns	hsa-mir-96	Carcinoma, Cervical	27764149	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China.
tissue_expression_ns	hsa-mir-106a	Carcinoma, Colon	28571588	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line.
tissue_expression_ns	hsa-mir-106b	Carcinoma, Colon	25755775	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	In situ hybridization analysis of the expression of miR-106b in colonic cancer.
tissue_expression_ns	hsa-mir-125b	Carcinoma, Colon	25421775	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	miR-145 and other 16 miRNAs may be used as diagnostic molecular markers of colon cancer, and miR100, miR125a-5p, miR125b, miR145 and miR145* may  become the molecular markers of colon cancer lymph node metastasis.
tissue_expression_ns	hsa-mir-126	Carcinoma, Colon	28714375	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	The association of miR-126-3p, miR-126-5p and miR-664-3p expression profiles with outcomes of patients with metastatic colorectal cancer treated with bevacizumab.
tissue_expression_ns	hsa-mir-145	Carcinoma, Colon	25421775	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	miR-145 and other 16 miRNAs may be used as diagnostic molecular markers of colon cancer, and miR100, miR125a-5p, miR125b, miR145 and miR146* may  become the molecular markers of colon cancer lymph node metastasis.
tissue_expression_ns	hsa-mir-17	Carcinoma, Colon	26465597	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	It is concluded that the expression of miR-17, miR-21, and miR-145 changes at early stages of the normal-adenoma-adenocarcinoma sequence. Thus, these microRNAs may play a role in the development of colon cancer.
tissue_expression_ns	hsa-mir-18	Carcinoma, Colon	26465597	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	It is concluded that the expression of miR-17, miR-21, and miR-145 changes at early stages of the normal-adenoma-adenocarcinoma sequence. Thus, these microRNAs may play a role in the development of colon cancer.
tissue_expression_ns	hsa-mir-19a	Carcinoma, Colon	26465597	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	It is concluded that the expression of miR-17, miR-21, and miR-145 changes at early stages of the normal-adenoma-adenocarcinoma sequence. Thus, these microRNAs may play a role in the development of colon cancer.
tissue_expression_ns	hsa-mir-19b-1	Carcinoma, Colon	26465597	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	It is concluded that the expression of miR-17, miR-21, and miR-145 changes at early stages of the normal-adenoma-adenocarcinoma sequence. Thus, these microRNAs may play a role in the development of colon cancer.
tissue_expression_ns	hsa-mir-200c	Carcinoma, Colon	28571588	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line.
tissue_expression_ns	hsa-mir-205	Carcinoma, Colon	28571588	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line.
tissue_expression_ns	hsa-mir-20a	Carcinoma, Colon	26465597	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	It is concluded that the expression of miR-17, miR-21, and miR-145 changes at early stages of the normal-adenoma-adenocarcinoma sequence. Thus, these microRNAs may play a role in the development of colon cancer.
tissue_expression_ns	hsa-mir-302d	Carcinoma, Colon	28571588	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line.
tissue_expression_ns	hsa-mir-324	Carcinoma, Colon	24882011	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage dysfunction and is associated with colon cancer.
tissue_expression_ns	hsa-mir-373	Carcinoma, Colon	28571588	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line.
tissue_expression_ns	hsa-mir-4454	Carcinoma, Colon	28571588	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line.
tissue_expression_ns	hsa-mir-483	Carcinoma, Colon	28571588	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line.
tissue_expression_ns	hsa-mir-5000	Carcinoma, Colon	24898979	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	MiR-5000-3p, miR-5009-3P and miR-552: potential microRNA biomarkers of side population cells in colon cancer.
tissue_expression_ns	hsa-mir-5009	Carcinoma, Colon	24898979	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	MiR-5000-3p, miR-5009-3P and miR-552: potential microRNA biomarkers of side population cells in colon cancer.
tissue_expression_ns	hsa-mir-512	Carcinoma, Colon	28571588	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line.
tissue_expression_ns	hsa-mir-552	Carcinoma, Colon	24898979	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	MiR-5000-3p, miR-5009-3P and miR-552: potential microRNA biomarkers of side population cells in colon cancer.
tissue_expression_ns	hsa-mir-664	Carcinoma, Colon	28714375	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	The association of miR-126-3p, miR-126-5p and miR-664-3p expression profiles with outcomes of patients with metastatic colorectal cancer treated with bevacizumab.
tissue_expression_ns	hsa-mir-92-1	Carcinoma, Colon	26465597	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	It is concluded that the expression of miR-17, miR-21, and miR-145 changes at early stages of the normal-adenoma-adenocarcinoma sequence. Thus, these microRNAs may play a role in the development of colon cancer.
tissue_expression_ns	hsa-mir-93	Carcinoma, Colon	28571588	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line.
tissue_expression_ns	hsa-mir-99b	Carcinoma, Colon	28571588	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line.
tissue_expression_ns	hsa-mir-372	Carcinoma, Embryonal	17011485	disease of cellular proliferation	DOID:3308		D018236		HP:0002898	Expression of miR-372 and miR-373 seems to be specifically associated with germ cell tumors, as most somatic tumors do not express these miRNAs.
tissue_expression_ns	hsa-mir-373	Carcinoma, Embryonal	17011485	disease of cellular proliferation	DOID:3308		D018236		HP:0002898	Expression of miR-372 and miR-373 seems to be specifically associated with germ cell tumors, as most somatic tumors do not express these miRNAs.
tissue_expression_ns	hsa-mir-141	Carcinoma, Endometrial	24363810	reproductive system disease	DOID:2871	D07.0	D016889	608089	HP:0012114	Aberrant microRNA expression in endometrial carcinoma using formalin-fixed paraffin-embedded (FFPE) tissues.
tissue_expression_ns	hsa-mir-182	Carcinoma, Endometrial	24363810	reproductive system disease	DOID:2871	D07.0	D016889	608089	HP:0012114	Aberrant microRNA expression in endometrial carcinoma using formalin-fixed paraffin-embedded (FFPE) tissues.
tissue_expression_ns	hsa-mir-200a	Carcinoma, Endometrial	24363810	reproductive system disease	DOID:2871	D07.0	D016889	608089	HP:0012114	Aberrant microRNA expression in endometrial carcinoma using formalin-fixed paraffin-embedded (FFPE) tissues.
tissue_expression_ns	hsa-mir-200b	Carcinoma, Endometrial	24363810	reproductive system disease	DOID:2871	D07.0	D016889	608089	HP:0012114	Aberrant microRNA expression in endometrial carcinoma using formalin-fixed paraffin-embedded (FFPE) tissues.
tissue_expression_ns	hsa-mir-205	Carcinoma, Endometrial	24363810	reproductive system disease	DOID:2871	D07.0	D016889	608089	HP:0012114	Aberrant microRNA expression in endometrial carcinoma using formalin-fixed paraffin-embedded (FFPE) tissues.
tissue_expression_ns	hsa-mir-106a	Carcinoma, Esophageal	20628822	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	Furthermore, miR-106a and miR-148a expression correlates with disease recurrence and tumor-related mortality.
tissue_expression_ns	hsa-mir-143	Carcinoma, Esophageal	25667498	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	Alterations of miRNA expression in ESCC can be correlated with the presence of common risk factors. The altered expression of certain miRNAs could be used as novel molecular markers of esophageal carcinoma.
tissue_expression_ns	hsa-mir-148a	Carcinoma, Esophageal	20628822	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	Furthermore, miR-106a and miR-148a expression correlates with disease recurrence and tumor-related mortality.
tissue_expression_ns	hsa-mir-203	Carcinoma, Esophageal	25667498	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	Alterations of miRNA expression in ESCC can be correlated with the presence of common risk factors. The altered expression of certain miRNAs could be used as novel molecular markers of esophageal carcinoma.
tissue_expression_ns	hsa-mir-205	Carcinoma, Esophageal	25667498	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	Alterations of miRNA expression in ESCC can be correlated with the presence of common risk factors. The altered expression of certain miRNAs could be used as novel molecular markers of esophageal carcinoma.
tissue_expression_ns	hsa-mir-205	Carcinoma, Esophageal	20628822	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	The expression of miR-21, miR-106a, miR-148a, miR-205 in formalin-fixed paraffin-embedded specimens was evaluated by TaqMan qPCR assays. Expression was compared with clinicopathological features of the cancers and outcome.
tissue_expression_ns	hsa-mir-21	Carcinoma, Esophageal	24680681	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	The expression of miR-21 and miR-375 predict prognosis of esophageal cancer.
tissue_expression_ns	hsa-mir-21	Carcinoma, Esophageal	25667498	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	Alterations of miRNA expression in ESCC can be correlated with the presence of common risk factors. The altered expression of certain miRNAs could be used as novel molecular markers of esophageal carcinoma.
tissue_expression_ns	hsa-mir-21	Carcinoma, Esophageal	20628822	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	The expression of miR-21, miR-106a, miR-148a, miR-205 in formalin-fixed paraffin-embedded specimens was evaluated by TaqMan qPCR assays. Expression was compared with clinicopathological features of the cancers and outcome.
tissue_expression_ns	hsa-mir-221	Carcinoma, Esophageal	25667498	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	Alterations of miRNA expression in ESCC can be correlated with the presence of common risk factors. The altered expression of certain miRNAs could be used as novel molecular markers of esophageal carcinoma.
tissue_expression_ns	hsa-mir-375	Carcinoma, Esophageal	24680681	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	The expression of miR-21 and miR-375 predict prognosis of esophageal cancer.
tissue_expression_ns	hsa-mir-106b	Carcinoma, Gastric	24040025	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	Candidate microRNA biomarkers in human gastric cancer: a systematic review and validation study.
tissue_expression_ns	hsa-mir-17	Carcinoma, Gastric	24040025	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	Candidate microRNA biomarkers in human gastric cancer: a systematic review and validation study.
tissue_expression_ns	hsa-mir-18a	Carcinoma, Gastric	24040025	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	Candidate microRNA biomarkers in human gastric cancer: a systematic review and validation study.
tissue_expression_ns	hsa-mir-1914	Carcinoma, Gastric	25730011	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	The miRNA expression patterns in different gastric adenocarcinoma subtypes may help discriminate between signet-ring cell and tubular gland cancer or other gastric cancer subtypes that would otherwise be difficult to identify using routine histological and immunohistochemical analyses. These preliminary data should be verified in further prospective studies.
tissue_expression_ns	hsa-mir-20a	Carcinoma, Gastric	24040025	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	Candidate microRNA biomarkers in human gastric cancer: a systematic review and validation study.
tissue_expression_ns	hsa-mir-21	Carcinoma, Gastric	24040025	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	Candidate microRNA biomarkers in human gastric cancer: a systematic review and validation study.
tissue_expression_ns	hsa-mir-378	Carcinoma, Gastric	24040025	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	Candidate microRNA biomarkers in human gastric cancer: a systematic review and validation study.
tissue_expression_ns	hsa-mir-499	Carcinoma, Gastric	25730011	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	The miRNA expression patterns in different gastric adenocarcinoma subtypes may help discriminate between signet-ring cell and tubular gland cancer or other gastric cancer subtypes that would otherwise be difficult to identify using routine histological and immunohistochemical analyses. These preliminary data should be verified in further prospective studies.
tissue_expression_ns	hsa-mir-524	Carcinoma, Gastric	25730011	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	The miRNA expression patterns in different gastric adenocarcinoma subtypes may help discriminate between signet-ring cell and tubular gland cancer or other gastric cancer subtypes that would otherwise be difficult to identify using routine histological and immunohistochemical analyses. These preliminary data should be verified in further prospective studies.
tissue_expression_ns	hsa-mir-628	Carcinoma, Gastric	25730011	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	The miRNA expression patterns in different gastric adenocarcinoma subtypes may help discriminate between signet-ring cell and tubular gland cancer or other gastric cancer subtypes that would otherwise be difficult to identify using routine histological and immunohistochemical analyses. These preliminary data should be verified in further prospective studies.
tissue_expression_ns	hsa-mir-638	Carcinoma, Gastric	24040025	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	Candidate microRNA biomarkers in human gastric cancer: a systematic review and validation study.
tissue_expression_ns	hsa-let-7a	Carcinoma, Hepatocellular	28440732	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Expression of microRNA let-7a positively correlates with hepatitis B virus replication in hepatocellular carcinoma tissues.
tissue_expression_ns	hsa-mir-106a	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-106a: involve
tissue_expression_ns	hsa-mir-106b	Carcinoma, Hepatocellular	25916067	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	A total of 54 differentially expressed miRNAs were identified, in which there were 13 miRNAs published to be related to HCC.
tissue_expression_ns	hsa-mir-106b	Carcinoma, Hepatocellular	29179453	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis
tissue_expression_ns	hsa-mir-122	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-122	Carcinoma, Hepatocellular	27874954	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The anti-cancer effects of cisplatin on hepatic cancer are associated with modulation of miRNA-21 and miRNA-122 expression.
tissue_expression_ns	hsa-mir-122	Carcinoma, Hepatocellular	28272709	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Expression of microRNA-122 and microRNA-22 in HBV-related liver cancer and the correlation with clinical features.
tissue_expression_ns	hsa-mir-125a	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-125a	Carcinoma, Hepatocellular	28878257	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Molecular mechanisms governing microRNA-125a expression in human hepatocellular carcinoma cells.
tissue_expression_ns	hsa-mir-125b	Carcinoma, Hepatocellular	21882851	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Many aberrantly expressed miRNAs were related to various cancers (e.g., miR-125b, hepatocellular carcinoma; miR-21, leukemia; miR-16, chronic lymphocytic leukemia;miR-192, pituitary adenomas; miR-199a-3p, ovarian cancer; miR-34a, pancreatic cancer).
tissue_expression_ns	hsa-mir-125b	Carcinoma, Hepatocellular	28984009	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MicroRNA-125b expression and intrahepatic metastasis are predictors for early recurrence after hepatocellular carcinoma resection.
tissue_expression_ns	hsa-mir-1285	Carcinoma, Hepatocellular	27554417	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Diagnosis of HCC for patients with cirrhosis using miRNA profiles of the tumor-surrounding tissue - A statistical model based on stepwise penalized logistic regression.
tissue_expression_ns	hsa-mir-129	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-130a	Carcinoma, Hepatocellular	26231037	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Systematic and integrative analysis of published datesets that compared the miRNA expression profiles between hepatocellular carcinoma (HCC) tissue and paired adjacent noncancerous liver tissue was performed to determine candidate HCC associated miRNAs. 
tissue_expression_ns	hsa-mir-130b	Carcinoma, Hepatocellular	26927562	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The expression and clinopathological significance of miR-130b in human hepatocellular carcinoma
tissue_expression_ns	hsa-mir-132	Carcinoma, Hepatocellular	28430373	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	A five-miRNA expression signature predicts survival in hepatocellular carcinoma.
tissue_expression_ns	hsa-mir-133b	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-142	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-1468	Carcinoma, Hepatocellular	28430373	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	A five-miRNA expression signature predicts survival in hepatocellular carcinoma.
tissue_expression_ns	hsa-mir-148a	Carcinoma, Hepatocellular	24798342	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression.
tissue_expression_ns	hsa-mir-155	Carcinoma, Hepatocellular	29291025	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value
tissue_expression_ns	hsa-mir-17	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-17-5p: involve
tissue_expression_ns	hsa-mir-182	Carcinoma, Hepatocellular	26728044	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In this study, fifteen microRNAs which were modulated in hepatic tissues and in tumors during the transition NAFLD-NASH-HCC are reported. Besides some already described, new and early dysregulated miRNAs were identified.Functional analyses are needed to validate the results here obtained, and to better define the role of these molecules in the progression of the hepatic disease.
tissue_expression_ns	hsa-mir-192	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-194	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-195	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-198	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-199a	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-199a	Carcinoma, Hepatocellular	26998997	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miTALOS v2: Analyzing Tissue Specific microRNA Function.
tissue_expression_ns	hsa-mir-199a	Carcinoma, Hepatocellular	22714032	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	the expression of miR-21, miR-221, miR-222 and miR-199a showing characteristic alterations in hepatocellular carcinoma also displayed deregulated expressions in these two early stages.
tissue_expression_ns	hsa-mir-199a	Carcinoma, Hepatocellular	29291025	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value
tissue_expression_ns	hsa-mir-199b	Carcinoma, Hepatocellular	26998997	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miTALOS v3: Analyzing Tissue Specific microRNA Function.
tissue_expression_ns	hsa-mir-20	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-200	Carcinoma, Hepatocellular	26998997	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miTALOS v4: Analyzing Tissue Specific microRNA Function.
tissue_expression_ns	hsa-mir-200a	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-200a	Carcinoma, Hepatocellular	29291025	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value
tissue_expression_ns	hsa-mir-203	Carcinoma, Hepatocellular	29291025	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value
tissue_expression_ns	hsa-mir-204	Carcinoma, Hepatocellular	28746200	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Promising significance of the association of miR-204-5p expression with clinicopathological features of hepatocellular carcinoma
tissue_expression_ns	hsa-mir-20a	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-20: involve
tissue_expression_ns	hsa-mir-20b	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-20: involve
tissue_expression_ns	hsa-mir-21	Carcinoma, Hepatocellular	25150373	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The results of the present study suggested miR-21 expression level could be a novel potential biomarker for HCC prognosis.
tissue_expression_ns	hsa-mir-21	Carcinoma, Hepatocellular	26231037	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Systematic and integrative analysis of published datesets that compared the miRNA expression profiles between hepatocellular carcinoma (HCC) tissue and paired adjacent noncancerous liver tissue was performed to determine candidate HCC associated miRNAs. 
tissue_expression_ns	hsa-mir-21	Carcinoma, Hepatocellular	27874954	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The anti-cancer effects of cisplatin on hepatic cancer are associated with modulation of miRNA-21 and miRNA-122 expression.
tissue_expression_ns	hsa-mir-21	Carcinoma, Hepatocellular	19120703	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In some cases, aberrantly expressed miRNAs could be linked to cancer-associated pathways, indicating a direct role in liver tumourigenesis. For example, up-regulation of mir-221 and mir-21 could promote cell cycle progression, reduce cell death and favour angiogenesis and invasion.
tissue_expression_ns	hsa-mir-21	Carcinoma, Hepatocellular	22714032	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	the expression of miR-21, miR-221, miR-222 and miR-199a showing characteristic alterations in hepatocellular carcinoma also displayed deregulated expressions in these two early stages.
tissue_expression_ns	hsa-mir-212	Carcinoma, Hepatocellular	28430373	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	A five-miRNA expression signature predicts survival in hepatocellular carcinoma.
tissue_expression_ns	hsa-mir-214	Carcinoma, Hepatocellular	26231037	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Systematic and integrative analysis of published datesets that compared the miRNA expression profiles between hepatocellular carcinoma (HCC) tissue and paired adjacent noncancerous liver tissue was performed to determine candidate HCC associated miRNAs. 
tissue_expression_ns	hsa-mir-214	Carcinoma, Hepatocellular	24804874	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Among the analysed miRNAs, high miR-214 expression was associated with smaller tumor size (p=0.019), whereas high miR-17-5p expression correlated with better Eastern Cooperative Oncology Group performance status (p=0.003).
tissue_expression_ns	hsa-mir-215	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-22	Carcinoma, Hepatocellular	28272709	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Expression of microRNA-122 and microRNA-22 in HBV-related liver cancer and the correlation with clinical features.
tissue_expression_ns	hsa-mir-22	Carcinoma, Hepatocellular	29291025	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value
tissue_expression_ns	hsa-mir-221	Carcinoma, Hepatocellular	26231037	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Systematic and integrative analysis of published datesets that compared the miRNA expression profiles between hepatocellular carcinoma (HCC) tissue and paired adjacent noncancerous liver tissue was performed to determine candidate HCC associated miRNAs. 
tissue_expression_ns	hsa-mir-221	Carcinoma, Hepatocellular	19120703	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In some cases, aberrantly expressed miRNAs could be linked to cancer-associated pathways, indicating a direct role in liver tumourigenesis. For example, up-regulation of mir-221 and mir-21 could promote cell cycle progression, reduce cell death and favour angiogenesis and invasion.
tissue_expression_ns	hsa-mir-221	Carcinoma, Hepatocellular	22714032	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	the expression of miR-21, miR-221, miR-222 and miR-199a showing characteristic alterations in hepatocellular carcinoma also displayed deregulated expressions in these two early stages.
tissue_expression_ns	hsa-mir-221	Carcinoma, Hepatocellular	29291025	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value
tissue_expression_ns	hsa-mir-222	Carcinoma, Hepatocellular	22714032	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	the expression of miR-21, miR-221, miR-222 and miR-199a showing characteristic alterations in hepatocellular carcinoma also displayed deregulated expressions in these two early stages.
tissue_expression_ns	hsa-mir-223	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-224	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-24	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-24-1	Carcinoma, Hepatocellular	23229173	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Human hepatocellular carcinoma cell-specific miRNAs reveal the differential expression of miR-24 and miR-27a in cirrhotic/non-cirrhotic HCC
tissue_expression_ns	hsa-mir-24-2	Carcinoma, Hepatocellular	23229173	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Human hepatocellular carcinoma cell-specific miRNAs reveal the differential expression of miR-24 and miR-27a in cirrhotic/non-cirrhotic HCC
tissue_expression_ns	hsa-mir-25	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-26a	Carcinoma, Hepatocellular	28218742	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MiRNA expression profiles reveal the involvement of miR-26a, miR-548l and miR-34a in hepatocellular carcinoma progression through regulation of ST3GAL5.
tissue_expression_ns	hsa-mir-26b	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-27a	Carcinoma, Hepatocellular	23229173	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Human hepatocellular carcinoma cell-specific miRNAs reveal the differential expression of miR-24 and miR-27a in cirrhotic/non-cirrhotic HCC
tissue_expression_ns	hsa-mir-27a	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-29a	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-29b	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-29b	Carcinoma, Hepatocellular	23863670	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The combined detection of miRNA-29b and AFP aids the diagnosis of PHC and the prediction of its prognosis.
tissue_expression_ns	hsa-mir-29c	Carcinoma, Hepatocellular	29291025	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value
tissue_expression_ns	hsa-mir-301a	Carcinoma, Hepatocellular	28430373	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	A five-miRNA expression signature predicts survival in hepatocellular carcinoma.
tissue_expression_ns	hsa-mir-302b	Carcinoma, Hepatocellular	24083596	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-302b suppresses HCC growth may due to targeting the EGFR/AKT2/CCND1 pathway.
tissue_expression_ns	hsa-mir-320	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-340	Carcinoma, Hepatocellular	26728044	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In this study, fifteen microRNAs which were modulated in hepatic tissues and in tumors during the transition NAFLD-NASH-HCC are reported. Besides some already described, new and early dysregulated miRNAs were identified.Functional analyses are needed to validate the results here obtained, and to better define the role of these molecules in the progression of the hepatic disease.
tissue_expression_ns	hsa-mir-34a	Carcinoma, Hepatocellular	28218742	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MiRNA expression profiles reveal the involvement of miR-26a, miR-548l and miR-34a in hepatocellular carcinoma progression through regulation of ST3GAL5.
tissue_expression_ns	hsa-mir-34a	Carcinoma, Hepatocellular	28950684	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Deregulation of miR-34a and Its Chaperon Hsp70 in Hepatitis C virus-Induced Liver Cirrhosis and Hepatocellular Carcinoma Patients
tissue_expression_ns	hsa-mir-34a	Carcinoma, Hepatocellular	29291025	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value
tissue_expression_ns	hsa-mir-34c	Carcinoma, Hepatocellular	29291025	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value
tissue_expression_ns	hsa-mir-369	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-432	Carcinoma, Hepatocellular	24592541	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Our study firstly demonstrated that miRNAs were differentially expressed in HCC-MVs compared with CHB and normal controls. Aberrant HCC-MVs miRNAs may play important roles in the development of HCC.
tissue_expression_ns	hsa-mir-484	Carcinoma, Hepatocellular	26728044	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In this study, fifteen microRNAs which were modulated in hepatic tissues and in tumors during the transition NAFLD-NASH-HCC are reported. Besides some already described, new and early dysregulated miRNAs were identified.Functional analyses are needed to validate the results here obtained, and to better define the role of these molecules in the progression of the hepatic disease.
tissue_expression_ns	hsa-mir-489	Carcinoma, Hepatocellular	28430373	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	A five-miRNA expression signature predicts survival in hepatocellular carcinoma.
tissue_expression_ns	hsa-mir-491	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-503	Carcinoma, Hepatocellular	29164842	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-503 is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma andseveral others
tissue_expression_ns	hsa-mir-512	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-522	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-542	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-548l	Carcinoma, Hepatocellular	28218742	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MiRNA expression profiles reveal the involvement of miR-26a, miR-548l and miR-34a in hepatocellular carcinoma progression through regulation of ST3GAL5.
tissue_expression_ns	hsa-mir-571	Carcinoma, Hepatocellular	26998997	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miTALOS v5: Analyzing Tissue Specific microRNA Function.
tissue_expression_ns	hsa-mir-574	Carcinoma, Hepatocellular	26728044	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In this study, fifteen microRNAs which were modulated in hepatic tissues and in tumors during the transition NAFLD-NASH-HCC are reported. Besides some already described, new and early dysregulated miRNAs were identified.Functional analyses are needed to validate the results here obtained, and to better define the role of these molecules in the progression of the hepatic disease.
tissue_expression_ns	hsa-mir-576	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-651	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-671	Carcinoma, Hepatocellular	24592541	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Our study firstly demonstrated that miRNAs were differentially expressed in HCC-MVs compared with CHB and normal controls. Aberrant HCC-MVs miRNAs may play important roles in the development of HCC.
tissue_expression_ns	hsa-mir-720	Carcinoma, Hepatocellular	26728044	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In this study, fifteen microRNAs which were modulated in hepatic tissues and in tumors during the transition NAFLD-NASH-HCC are reported. Besides some already described, new and early dysregulated miRNAs were identified.Functional analyses are needed to validate the results here obtained, and to better define the role of these molecules in the progression of the hepatic disease.
tissue_expression_ns	hsa-mir-9	Carcinoma, Hepatocellular	29291025	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value
tissue_expression_ns	hsa-mir-92	Carcinoma, Hepatocellular	26229398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers.
tissue_expression_ns	hsa-mir-92a-1	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-92: involve
tissue_expression_ns	hsa-mir-92a-1	Carcinoma, Hepatocellular	20518884	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-92a:Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development
tissue_expression_ns	hsa-mir-92a-2	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-92: involve
tissue_expression_ns	hsa-mir-92a-2	Carcinoma, Hepatocellular	20518884	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-92a:Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development
tissue_expression_ns	hsa-mir-92b	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-92: involve
tissue_expression_ns	hsa-mir-93	Carcinoma, Hepatocellular	25633810	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-93 stimulated cell proliferation,migration, and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC.
tissue_expression_ns	hsa-mir-943	Carcinoma, Hepatocellular	27554417	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Diagnosis of HCC for patients with cirrhosis using miRNA profiles of the tumor-surrounding tissue - A statistical model based on stepwise penalized logistic regression.
tissue_expression_ns	hsa-let-7a	Carcinoma, Hepatocellular, HBV-Related	24273923							Analysis of microRNA expression profiles in human hepatitis B virus-related hepatocellular carcinoma.
tissue_expression_ns	hsa-let-7c	Carcinoma, Hepatocellular, HBV-Related	24273923							Analysis of microRNA expression profiles in human hepatitis B virus-related hepatocellular carcinoma.
tissue_expression_ns	hsa-mir-138	Carcinoma, Hepatocellular, HBV-Related	24273923							Analysis of microRNA expression profiles in human hepatitis B virus-related hepatocellular carcinoma.
tissue_expression_ns	hsa-mir-183	Carcinoma, Hepatocellular, HBV-Related	24273923							Analysis of microRNA expression profiles in human hepatitis B virus-related hepatocellular carcinoma.
tissue_expression_ns	hsa-mir-196a	Carcinoma, Hepatocellular, HBV-Related	24273923							Analysis of microRNA expression profiles in human hepatitis B virus-related hepatocellular carcinoma.
tissue_expression_ns	hsa-mir-96	Carcinoma, Hepatocellular, HBV-Related	24273923							Analysis of microRNA expression profiles in human hepatitis B virus-related hepatocellular carcinoma.
tissue_expression_ns	hsa-mir-10a	Carcinoma, Laryngeal	25266939	disease of cellular proliferation	DOID:2600	C32.3	D007822	21198	HP:0012118	MicroRNA-10a-5p and microRNA-34c-5p in laryngeal epithelial premalignant lesions:differential expression and clinicopathological correlation.
tissue_expression_ns	hsa-mir-1276	Carcinoma, Laryngeal	27916417	disease of cellular proliferation	DOID:2600	C32.3	D007822	21198	HP:0012118	CCR6 was positively associated with miR-20a-5p, miR-489 and negatively related to miR-29-3p, miR-632 and miR-1276 in laryngeal cancer tissues
tissue_expression_ns	hsa-mir-20a	Carcinoma, Laryngeal	27916417	disease of cellular proliferation	DOID:2600	C32.3	D007822	21198	HP:0012118	CCR6 was positively associated with miR-20a-5p, miR-489 and negatively related to miR-29-3p, miR-632 and miR-1277 in laryngeal cancer tissues
tissue_expression_ns	hsa-mir-29	Carcinoma, Laryngeal	27916417	disease of cellular proliferation	DOID:2600	C32.3	D007822	21198	HP:0012118	CCR6 was positively associated with miR-20a-5p, miR-489 and negatively related to miR-29-3p, miR-632 and miR-1278 in laryngeal cancer tissues
tissue_expression_ns	hsa-mir-34c	Carcinoma, Laryngeal	25266939	disease of cellular proliferation	DOID:2600	C32.3	D007822	21198	HP:0012118	MicroRNA-10a-5p and microRNA-34c-5p in laryngeal epithelial premalignant lesions:differential expression and clinicopathological correlation.
tissue_expression_ns	hsa-mir-489	Carcinoma, Laryngeal	27916417	disease of cellular proliferation	DOID:2600	C32.3	D007822	21198	HP:0012118	CCR6 was positively associated with miR-20a-5p, miR-489 and negatively related to miR-29-3p, miR-632 and miR-1279 in laryngeal cancer tissues
tissue_expression_ns	hsa-mir-632	Carcinoma, Laryngeal	27916417	disease of cellular proliferation	DOID:2600	C32.3	D007822	21198	HP:0012118	CCR6 was positively associated with miR-20a-5p, miR-489 and negatively related to miR-29-3p, miR-632 and miR-1280 in laryngeal cancer tissues
tissue_expression_ns	hsa-mir-125a	Carcinoma, Lung	27748875	disease of cellular proliferation	DOID:3905	C34.90	D008175			MicroRNA expression profiles of granulocytic myeloid‑derived suppressor cells from mice bearing Lewis lung carcinoma.
tissue_expression_ns	hsa-mir-125b	Carcinoma, Lung	27748875	disease of cellular proliferation	DOID:3905	C34.90	D008175			MicroRNA expression profiles of granulocytic myeloid‑derived suppressor cells from mice bearing Lewis lung carcinoma.
tissue_expression_ns	hsa-mir-128	Carcinoma, Lung	27748875	disease of cellular proliferation	DOID:3905	C34.90	D008175			MicroRNA expression profiles of granulocytic myeloid‑derived suppressor cells from mice bearing Lewis lung carcinoma.
tissue_expression_ns	hsa-mir-149	Carcinoma, Lung	27748875	disease of cellular proliferation	DOID:3905	C34.90	D008175			MicroRNA expression profiles of granulocytic myeloid‑derived suppressor cells from mice bearing Lewis lung carcinoma.
tissue_expression_ns	hsa-mir-192	Carcinoma, Lung	27748875	disease of cellular proliferation	DOID:3905	C34.90	D008175			MicroRNA expression profiles of granulocytic myeloid‑derived suppressor cells from mice bearing Lewis lung carcinoma.
tissue_expression_ns	hsa-mir-203	Carcinoma, Lung	26397233	disease of cellular proliferation	DOID:3905	C34.90	D008175			Cumulatively,our data purport that p53 not only increased Puma expression directly, but that it may also do so through miR-203. Additionally, functional studies revealed that miR-203 overexpression induced apoptosis and inhibited cell invasiveness.
tissue_expression_ns	hsa-mir-27a	Carcinoma, Lung	27748875	disease of cellular proliferation	DOID:3905	C34.90	D008175			MicroRNA expression profiles of granulocytic myeloid‑derived suppressor cells from mice bearing Lewis lung carcinoma.
tissue_expression_ns	hsa-mir-328	Carcinoma, Lung	27748875	disease of cellular proliferation	DOID:3905	C34.90	D008175			MicroRNA expression profiles of granulocytic myeloid‑derived suppressor cells from mice bearing Lewis lung carcinoma.
tissue_expression_ns	hsa-mir-350	Carcinoma, Lung	27748875	disease of cellular proliferation	DOID:3905	C34.90	D008175			MicroRNA expression profiles of granulocytic myeloid‑derived suppressor cells from mice bearing Lewis lung carcinoma.
tissue_expression_ns	hsa-mir-486	Carcinoma, Lung	27748875	disease of cellular proliferation	DOID:3905	C34.90	D008175			MicroRNA expression profiles of granulocytic myeloid‑derived suppressor cells from mice bearing Lewis lung carcinoma.
tissue_expression_ns	hsa-let-7a	Carcinoma, Lung, Non-Small-Cell	20975375			C34.90	D002289		HP:0030358	In an exploratory study, we determined whether expression of six miRNAs (let-7a, miR-7, miR-21, miR-155, miR-210, and miR-221) previously reported to correlate with invasiveness or outcome in various human malignancies were associated with tumor recurrence in patients with resected stage I NSCLC.
tissue_expression_ns	hsa-let-7a	Carcinoma, Lung, Non-Small-Cell	20978195			C34.90	D002289		HP:0030358	We also analyzed the association of TP53 mutation status and miR-34a/b/c expression, epidermal growth factor receptor and KRAS mutation status, and miR-21 and Let-7a expression.
tissue_expression_ns	hsa-let-7a	Carcinoma, Lung, Non-Small-Cell	23043708			C34.90	D002289		HP:0030358	The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls.
tissue_expression_ns	hsa-let-7a	Carcinoma, Lung, Non-Small-Cell	24802132			C34.90	D002289		HP:0030358	Before PRFA, tumor suppressor let-7a and miR-34a were downregulated whereas oncomiR miR-21 was upregulated in primary tumors, and let-7a and miR-126 levels were downregulated whereas oncomiRs miR-21, miR-155 and miR-17-5p/miR-20b levels were upregulated in secondary tumors.
tissue_expression_ns	hsa-let-7b	Carcinoma, Lung, Non-Small-Cell	28534369			C34.90	D002289		HP:0030358	The relationship between miR-17-5p, miR-92a, and let-7b expression with non-small cell lung cancer targeted drug resistance.
tissue_expression_ns	hsa-mir-10b	Carcinoma, Lung, Non-Small-Cell	24448358			C34.90	D002289		HP:0030358	Expression of miR-128, -10b, -502-3p and -192 differed between SCC and AC, and miR-128 and -192 - between NLP and NSCLC.
tissue_expression_ns	hsa-mir-126	Carcinoma, Lung, Non-Small-Cell	27665734			C34.90	D002289		HP:0030358	Matrine induces cell cycle arrest and apoptosis with recovery of the expression of miR-126 in the A549 non-small cell lung cancer cell line.
tissue_expression_ns	hsa-mir-128	Carcinoma, Lung, Non-Small-Cell	24448358			C34.90	D002289		HP:0030358	Expression of miR-128, -10b, -502-3p and -192 differed between SCC and AC, and miR-128 and -192 - between NLP and NSCLC.
tissue_expression_ns	hsa-mir-130a	Carcinoma, Lung, Non-Small-Cell	20625274			C34.90	D002289		HP:0030358	Multivariate Cox regression analysis showed that miRNA-130a was an independent prognostic factor for patients with NSCLC.
tissue_expression_ns	hsa-mir-143	Carcinoma, Lung, Non-Small-Cell	23043708			C34.90	D002289		HP:0030358	The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls.
tissue_expression_ns	hsa-mir-145	Carcinoma, Lung, Non-Small-Cell	23043708			C34.90	D002289		HP:0030358	The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls.
tissue_expression_ns	hsa-mir-155	Carcinoma, Lung, Non-Small-Cell	20975375			C34.90	D002289		HP:0030358	In an exploratory study, we determined whether expression of six miRNAs (let-7a, miR-7, miR-21, miR-155, miR-210, and miR-221) previously reported to correlate with invasiveness or outcome in various human malignancies were associated with tumor recurrence in patients with resected stage I NSCLC.
tissue_expression_ns	hsa-mir-155	Carcinoma, Lung, Non-Small-Cell	23043708			C34.90	D002289		HP:0030358	The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls.
tissue_expression_ns	hsa-mir-15a	Carcinoma, Lung, Non-Small-Cell	28537679			C34.90	D002289		HP:0030358	MiR-15a expression analysis in non-small cell lung cancer A549 cells under local hypoxia microenvironment.
tissue_expression_ns	hsa-mir-17	Carcinoma, Lung, Non-Small-Cell	23043708			C34.90	D002289		HP:0030358	The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls.
tissue_expression_ns	hsa-mir-17	Carcinoma, Lung, Non-Small-Cell	28534369			C34.90	D002289		HP:0030358	The relationship between miR-17-5p, miR-92a, and let-7b expression with non-small cell lung cancer targeted drug resistance.
tissue_expression_ns	hsa-mir-182	Carcinoma, Lung, Non-Small-Cell	23043708			C34.90	D002289		HP:0030358	The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls.
tissue_expression_ns	hsa-mir-192	Carcinoma, Lung, Non-Small-Cell	24448358			C34.90	D002289		HP:0030358	Expression of miR-128, -10b, -502-3p and -192 differed between SCC and AC, and miR-128 and -192 - between NLP and NSCLC.
tissue_expression_ns	hsa-mir-200b	Carcinoma, Lung, Non-Small-Cell	27876017			C34.90	D002289		HP:0030358	miR-27b and miR-200b levels were determined in resected adenocarcinoma and squamous cell carcinoma samples by qRT-PCR
tissue_expression_ns	hsa-mir-203	Carcinoma, Lung, Non-Small-Cell	29088807			C34.90	D002289		HP:0030358	Identification of microRNA differentially expressed in three subtypes of non-small cell lung cancer and in silico functional analysis.
tissue_expression_ns	hsa-mir-205	Carcinoma, Lung, Non-Small-Cell	23043708			C34.90	D002289		HP:0030358	The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls.
tissue_expression_ns	hsa-mir-205	Carcinoma, Lung, Non-Small-Cell	23759980			C34.90	D002289		HP:0030358	Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma.
tissue_expression_ns	hsa-mir-205	Carcinoma, Lung, Non-Small-Cell	29088807			C34.90	D002289		HP:0030358	Identification of microRNA differentially expressed in three subtypes of non-small cell lung cancer and in silico functional analysis.
tissue_expression_ns	hsa-mir-21	Carcinoma, Lung, Non-Small-Cell	20975375			C34.90	D002289		HP:0030358	In an exploratory study, we determined whether expression of six miRNAs (let-7a, miR-7, miR-21, miR-155, miR-210, and miR-221) previously reported to correlate with invasiveness or outcome in various human malignancies were associated with tumor recurrence in patients with resected stage I NSCLC.
tissue_expression_ns	hsa-mir-21	Carcinoma, Lung, Non-Small-Cell	20978195			C34.90	D002289		HP:0030358	We also analyzed the association of TP53 mutation status and miR-34a/b/c expression, epidermal growth factor receptor and KRAS mutation status, and miR-21 and Let-7a expression.
tissue_expression_ns	hsa-mir-21	Carcinoma, Lung, Non-Small-Cell	23043708			C34.90	D002289		HP:0030358	The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls.
tissue_expression_ns	hsa-mir-21	Carcinoma, Lung, Non-Small-Cell	28799568			C34.90	D002289		HP:0030358	Association of long non-coding RNA H19 and microRNA-21 expression with the biological features and prognosis of non-small cell lung cancer.
tissue_expression_ns	hsa-mir-210	Carcinoma, Lung, Non-Small-Cell	20975375			C34.90	D002289		HP:0030358	In an exploratory study, we determined whether expression of six miRNAs (let-7a, miR-7, miR-21, miR-155, miR-210, and miR-221) previously reported to correlate with invasiveness or outcome in various human malignancies were associated with tumor recurrence in patients with resected stage I NSCLC.
tissue_expression_ns	hsa-mir-210	Carcinoma, Lung, Non-Small-Cell	23043708			C34.90	D002289		HP:0030358	The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls.
tissue_expression_ns	hsa-mir-221	Carcinoma, Lung, Non-Small-Cell	20975375			C34.90	D002289		HP:0030358	In an exploratory study, we determined whether expression of six miRNAs (let-7a, miR-7, miR-21, miR-155, miR-210, and miR-221) previously reported to correlate with invasiveness or outcome in various human malignancies were associated with tumor recurrence in patients with resected stage I NSCLC.
tissue_expression_ns	hsa-mir-27b	Carcinoma, Lung, Non-Small-Cell	27876017			C34.90	D002289		HP:0030358	miR-27b and miR-200b levels were determined in resected adenocarcinoma and squamous cell carcinoma samples by qRT-PCR
tissue_expression_ns	hsa-mir-34a	Carcinoma, Lung, Non-Small-Cell	20978195			C34.90	D002289		HP:0030358	We also analyzed the association of TP53 mutation status and miR-34a/b/c expression, epidermal growth factor receptor and KRAS mutation status, and miR-21 and Let-7a expression.
tissue_expression_ns	hsa-mir-34b	Carcinoma, Lung, Non-Small-Cell	20978195			C34.90	D002289		HP:0030358	We also analyzed the association of TP53 mutation status and miR-34a/b/c expression, epidermal growth factor receptor and KRAS mutation status, and miR-21 and Let-7a expression.
tissue_expression_ns	hsa-mir-34c	Carcinoma, Lung, Non-Small-Cell	20978195			C34.90	D002289		HP:0030358	We also analyzed the association of TP53 mutation status and miR-34a/b/c expression, epidermal growth factor receptor and KRAS mutation status, and miR-21 and Let-7a expression.
tissue_expression_ns	hsa-mir-372	Carcinoma, Lung, Non-Small-Cell	23043708			C34.90	D002289		HP:0030358	The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls.
tissue_expression_ns	hsa-mir-375	Carcinoma, Lung, Non-Small-Cell	29088807			C34.90	D002289		HP:0030358	Identification of microRNA differentially expressed in three subtypes of non-small cell lung cancer and in silico functional analysis.
tissue_expression_ns	hsa-mir-502	Carcinoma, Lung, Non-Small-Cell	24448358			C34.90	D002289		HP:0030358	Expression of miR-128, -10b, -502-3p and -192 differed between SCC and AC, and miR-128 and -192 - between NLP and NSCLC.
tissue_expression_ns	hsa-mir-662	Carcinoma, Lung, Non-Small-Cell	24448358			C34.90	D002289		HP:0030358	Of these six miRNAs, miR-662, -192 and -192* were confirmed as  prognostic in the independent SCC cohort.
tissue_expression_ns	hsa-mir-7	Carcinoma, Lung, Non-Small-Cell	20975375			C34.90	D002289		HP:0030358	In an exploratory study, we determined whether expression of six miRNAs (let-7a, miR-7, miR-21, miR-155, miR-210, and miR-221) previously reported to correlate with invasiveness or outcome in various human malignancies were associated with tumor recurrence in patients with resected stage I NSCLC.
tissue_expression_ns	hsa-mir-92	Carcinoma, Lung, Non-Small-Cell	23043708			C34.90	D002289		HP:0030358	The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls.
tissue_expression_ns	hsa-mir-92a	Carcinoma, Lung, Non-Small-Cell	28534369			C34.90	D002289		HP:0030358	The relationship between miR-17-5p, miR-92a, and let-7b expression with non-small cell lung cancer targeted drug resistance.
tissue_expression_ns	hsa-let-7d	Carcinoma, Lung, Non-Small-Cell	25873351			C34.90	D002289		HP:0030358	mRNA and microRNA expression profiles of radioresistant NCI-H520 non-small cell lung cancer cells.
tissue_expression_ns	hsa-let-7e	Carcinoma, Lung, Non-Small-Cell	24945821			C34.90	D002289		HP:0030358	Differential expression of miR-125a-5p and let-7e predicts the progression and prognosis of non-small cell lung cancer.
tissue_expression_ns	hsa-mir-124a	Carcinoma, Lung, Non-Small-Cell	24113142			C34.90	D002289		HP:0030358	The developed prediction algorithm is a valuable potential biomarker for assisting lung cancer diagnosis in minimal biopsy material. A prospective validation is required to measure the enhancement of diagnostic accuracy of our current clinical practice.
tissue_expression_ns	hsa-mir-125a	Carcinoma, Lung, Non-Small-Cell	24945821			C34.90	D002289		HP:0030358	Differential expression of miR-125a-5p and let-7e predicts the progression and prognosis of non-small cell lung cancer.
tissue_expression_ns	hsa-mir-126	Carcinoma, Lung, Non-Small-Cell	24113142			C34.90	D002289		HP:0030358	The developed prediction algorithm is a valuable potential biomarker for assisting lung cancer diagnosis in minimal biopsy material. A prospective validation is required to measure the enhancement of diagnostic accuracy of our current clinical practice.
tissue_expression_ns	hsa-mir-127	Carcinoma, Lung, Non-Small-Cell	25873351			C34.90	D002289		HP:0030358	mRNA and microRNA expression profiles of radioresistant NCI-H520 non-small cell lung cancer cells.
tissue_expression_ns	hsa-mir-143	Carcinoma, Lung, Non-Small-Cell	24286416			C34.90	D002289		HP:0030358	It is indicated that there is a potential for using miR-143 as a novel diagnostic biomarker for NSCLC. Moreover, miR-150 can be a highly accurate  marker for differentiating adenocarcinoma from squamous cell carcinoma.
tissue_expression_ns	hsa-mir-143	Carcinoma, Lung, Non-Small-Cell	25862841			C34.90	D002289		HP:0030358	miRNA expression profiling of sputum and BAL fluids represent a potential means to detect early-stage NSCLC.
tissue_expression_ns	hsa-mir-150	Carcinoma, Lung, Non-Small-Cell	24286416			C34.90	D002289		HP:0030358	It is indicated that there is a potential for using miR-143 as a novel diagnostic biomarker for NSCLC. Moreover, miR-150 can be a highly accurate  marker for differentiating adenocarcinoma from squamous cell carcinoma.
tissue_expression_ns	hsa-mir-155	Carcinoma, Lung, Non-Small-Cell	25862841			C34.90	D002289		HP:0030358	miRNA expression profiling of sputum and BAL fluids represent a potential means to detect early-stage NSCLC.
tissue_expression_ns	hsa-mir-155	Carcinoma, Lung, Non-Small-Cell	24460255			C34.90	D002289		HP:0030358	the miR-155 expression level plays a prognostic role in patients with cancer, especially NSCLCs and digestive system carcinomas.
tissue_expression_ns	hsa-mir-155	Carcinoma, Lung, Non-Small-Cell	25873351			C34.90	D002289		HP:0030358	mRNA and microRNA expression profiles of radioresistant NCI-H520 non-small cell lung cancer cells.
tissue_expression_ns	hsa-mir-15b	Carcinoma, Lung, Non-Small-Cell	22389695			C34.90	D002289		HP:0030358	A combination of two differentially expressed miRNAs miR-15b and miR-27b, was able to discriminate NSCLC from healthy controls with sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 100% in the training set.
tissue_expression_ns	hsa-mir-197	Carcinoma, Lung, Non-Small-Cell	25867273			C34.90	D002289		HP:0030358	The cost-effective expression analysis of miR-197 could constitute a novel molecular tool for NSCLC management.
tissue_expression_ns	hsa-mir-200c	Carcinoma, Lung, Non-Small-Cell	24113142			C34.90	D002289		HP:0030358	The developed prediction algorithm is a valuable potential biomarker for assisting lung cancer diagnosis in minimal biopsy material. A prospective validation is required to measure the enhancement of diagnostic accuracy of our current clinical practice.
tissue_expression_ns	hsa-mir-21	Carcinoma, Lung, Non-Small-Cell	25862841			C34.90	D002289		HP:0030358	miRNA expression profiling of sputum and BAL fluids represent a potential means to detect early-stage NSCLC.
tissue_expression_ns	hsa-mir-210	Carcinoma, Lung, Non-Small-Cell	25862841			C34.90	D002289		HP:0030358	miRNA expression profiling of sputum and BAL fluids represent a potential means to detect early-stage NSCLC.
tissue_expression_ns	hsa-mir-27b	Carcinoma, Lung, Non-Small-Cell	22389695			C34.90	D002289		HP:0030358	A combination of two differentially expressed miRNAs miR-15b and miR-27b, was able to discriminate NSCLC from healthy controls with sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 100% in the training set.
tissue_expression_ns	hsa-mir-34	Carcinoma, Lung, Non-Small-Cell	24113142			C34.90	D002289		HP:0030358	The developed prediction algorithm is a valuable potential biomarker for assisting lung cancer diagnosis in minimal biopsy material. A prospective validation is required to measure the enhancement of diagnostic accuracy of our current clinical practice.
tissue_expression_ns	hsa-mir-372	Carcinoma, Lung, Non-Small-Cell	25862841			C34.90	D002289		HP:0030358	miRNA expression profiling of sputum and BAL fluids represent a potential means to detect early-stage NSCLC.
tissue_expression_ns	hsa-mir-9	Carcinoma, Lung, Non-Small-Cell	24113142			C34.90	D002289		HP:0030358	The developed prediction algorithm is a valuable potential biomarker for assisting lung cancer diagnosis in minimal biopsy material. A prospective validation is required to measure the enhancement of diagnostic accuracy of our current clinical practice.
tissue_expression_ns	hsa-mir-155	Carcinoma, Lung, Small-Cell	27682492			C34.90	D055752	182280	HP:0030357	Changes of microRNAs profiling in mesothelial cells exposed to multi-walled carbon nanotubes.
tissue_expression_ns	hsa-mir-28	Carcinoma, Lung, Small-Cell	27682492			C34.90	D055752	182280	HP:0030357	Changes of microRNAs profiling in mesothelial cells exposed to multi-walled carbon nanotubes.
tissue_expression_ns	hsa-mir-30	Carcinoma, Lung, Small-Cell	27682492			C34.90	D055752	182280	HP:0030357	Changes of microRNAs profiling in mesothelial cells exposed to multi-walled carbon nanotubes.
tissue_expression_ns	hsa-mir-324	Carcinoma, Lung, Small-Cell	27682492			C34.90	D055752	182280	HP:0030357	Changes of microRNAs profiling in mesothelial cells exposed to multi-walled carbon nanotubes.
tissue_expression_ns	hsa-mir-34c	Carcinoma, Lung, Small-Cell	27682492			C34.90	D055752	182280	HP:0030357	Changes of microRNAs profiling in mesothelial cells exposed to multi-walled carbon nanotubes.
tissue_expression_ns	hsa-mir-302a	Carcinoma, Mucoepidermoid	29095552	disease of cellular proliferation	DOID:4531		D018277			miRNA expression profile of mucoepidermoid carcinoma.
tissue_expression_ns	hsa-let-7i	Carcinoma, Nasopharyngeal	29455649	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	miR-142, miR-26a, miR-141 and let-7i have significant prognostic power
tissue_expression_ns	hsa-mir-130a	Carcinoma, Nasopharyngeal	27350400	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	hsa-miR-205, hsa-miR-18b, hsa-miR-632, hsa-miR-130a, and hsa-miR-34b may be related to the development of nasopharyngeal carcinoma
tissue_expression_ns	hsa-mir-1323	Carcinoma, Nasopharyngeal	24367666	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing.
tissue_expression_ns	hsa-mir-141	Carcinoma, Nasopharyngeal	29455649	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	miR-142, miR-26a, miR-141 and let-7i have significant prognostic power
tissue_expression_ns	hsa-mir-142	Carcinoma, Nasopharyngeal	29455649	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	miR-142, miR-26a, miR-141 and let-7i have significant prognostic power
tissue_expression_ns	hsa-mir-18b	Carcinoma, Nasopharyngeal	27350400	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	hsa-miR-205, hsa-miR-18b, hsa-miR-632, hsa-miR-130a, and hsa-miR-34b may be related to the development of nasopharyngeal carcinoma
tissue_expression_ns	hsa-mir-205	Carcinoma, Nasopharyngeal	27350400	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	hsa-miR-205, hsa-miR-18b, hsa-miR-632, hsa-miR-130a, and hsa-miR-34b may be related to the development of nasopharyngeal carcinoma
tissue_expression_ns	hsa-mir-205	Carcinoma, Nasopharyngeal	28931826	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	MicroRNA profiling study reveals miR-150 in association with metastasis in nasopharyngeal carcinoma
tissue_expression_ns	hsa-mir-26a	Carcinoma, Nasopharyngeal	29455649	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	miR-142, miR-26a, miR-141 and let-7i have significant prognostic power
tissue_expression_ns	hsa-mir-324	Carcinoma, Nasopharyngeal	24367666	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing.
tissue_expression_ns	hsa-mir-34b	Carcinoma, Nasopharyngeal	26330189	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	Integrated analysis of the differential cellular and EBV miRNA expression profiles in microdissected nasopharyngeal carcinoma and non-cancerous nasopharyngeal tissues.
tissue_expression_ns	hsa-mir-34b	Carcinoma, Nasopharyngeal	27350400	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	hsa-miR-205, hsa-miR-18b, hsa-miR-632, hsa-miR-130a, and hsa-miR-34b may be related to the development of nasopharyngeal carcinoma
tissue_expression_ns	hsa-mir-34c	Carcinoma, Nasopharyngeal	24367666	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing.
tissue_expression_ns	hsa-mir-371a	Carcinoma, Nasopharyngeal	24367666	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing.
tissue_expression_ns	hsa-mir-4501	Carcinoma, Nasopharyngeal	24367666	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing.
tissue_expression_ns	hsa-mir-632	Carcinoma, Nasopharyngeal	27350400	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	hsa-miR-205, hsa-miR-18b, hsa-miR-632, hsa-miR-130a, and hsa-miR-34b may be related to the development of nasopharyngeal carcinoma
tissue_expression_ns	hsa-mir-93	Carcinoma, Nasopharyngeal	24367666	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing.
tissue_expression_ns	hsa-mir-10b	Carcinoma, Oral	22318752	gastrointestinal system disease	DOID:0050610					hsa-mir-10b has the potential for Oncogenic Function and Early Detection in Oral Cancer as Identified by microRNA Profiling.
tissue_expression_ns	hsa-mir-1271	Carcinoma, Ovarian	24816756	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer.
tissue_expression_ns	hsa-mir-130b	Carcinoma, Ovarian	24816756	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer.
tissue_expression_ns	hsa-mir-135b	Carcinoma, Ovarian	24816756	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer.
tissue_expression_ns	hsa-mir-141	Carcinoma, Ovarian	24816756	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer.
tissue_expression_ns	hsa-mir-143	Carcinoma, Ovarian	27748916	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	Dysregulation of micro-143-3p and BALBP1 contributes to the pathogenesis of the development of ovarian carcinoma.
tissue_expression_ns	hsa-mir-15b	Carcinoma, Ovarian	24816756	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer.
tissue_expression_ns	hsa-mir-182	Carcinoma, Ovarian	24816756	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer.
tissue_expression_ns	hsa-mir-183	Carcinoma, Ovarian	24816756	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer.
tissue_expression_ns	hsa-mir-196b	Carcinoma, Ovarian	25964536	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC.
tissue_expression_ns	hsa-mir-19b	Carcinoma, Ovarian	25964536	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC.
tissue_expression_ns	hsa-mir-3198	Carcinoma, Ovarian	25964536	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC.
tissue_expression_ns	hsa-mir-3201	Carcinoma, Ovarian	25964536	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC.
tissue_expression_ns	hsa-mir-3613	Carcinoma, Ovarian	25964536	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC.
tissue_expression_ns	hsa-mir-381	Carcinoma, Ovarian	27757782	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	Identification of candidate biomarkers and analysis of prognostic values in ovarian cancer by integrated bioinformatics analysis.
tissue_expression_ns	hsa-mir-424	Carcinoma, Ovarian	27757782	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	Identification of candidate biomarkers and analysis of prognostic values in ovarian cancer by integrated bioinformatics analysis.
tissue_expression_ns	hsa-mir-510	Carcinoma, Ovarian	26497752	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	Profile of differentially expressed miRNAs in high-grade serous carcinoma and clear cell ovarian carcinoma, and the expression of miR-510 in ovarian carcinoma.
tissue_expression_ns	hsa-mir-551b	Carcinoma, Ovarian	25964536	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC.
tissue_expression_ns	hsa-mir-574	Carcinoma, Ovarian	24816756	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer.
tissue_expression_ns	hsa-mir-7515	Carcinoma, Ovarian	25964536	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC.
tissue_expression_ns	hsa-mir-8084	Carcinoma, Ovarian	25964536	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC.
tissue_expression_ns	hsa-mir-96	Carcinoma, Ovarian	24816756	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer.
tissue_expression_ns	hsa-mir-29a	Carcinoma, Ovarian, Serous	27063471	endocrine system disease	DOID:0050933					miR-29a and its target DNMT3A are novel candidate biomarkers of longer and shorter survival, respectively, in metastatic high-grade serous carcinoma.
tissue_expression_ns	hsa-mir-30a	Carcinoma, Ovarian, Serous	24676806	endocrine system disease	DOID:0050933					The expression of miR-30a* and miR-30e* is associated with a dualistic model for grading ovarian papillary serious carcinoma.
tissue_expression_ns	hsa-mir-30e	Carcinoma, Ovarian, Serous	24676806	endocrine system disease	DOID:0050933					The expression of miR-30a* and miR-30e* is associated with a dualistic model for grading ovarian papillary serious carcinoma.
tissue_expression_ns	hsa-mir-483	Carcinoma, Ovarian, Serous	23836287	endocrine system disease	DOID:0050933					MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma.
tissue_expression_ns	hsa-mir-508	Carcinoma, Ovarian, Serous	23836287	endocrine system disease	DOID:0050933					MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma.
tissue_expression_ns	hsa-mir-509	Carcinoma, Ovarian, Serous	23836287	endocrine system disease	DOID:0050933					MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma.
tissue_expression_ns	hsa-mir-510	Carcinoma, Ovarian, Serous	23836287	endocrine system disease	DOID:0050933					MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma.
tissue_expression_ns	hsa-mir-1178	Carcinoma, Pancreatic	28592083			C25.3	C562463	260350	HP:0002894	Correlation between miR-1178 expression and clinicopathological significance in human pancreatic cancer.
tissue_expression_ns	hsa-mir-155	Carcinoma, Pancreatic	27840954			C25.3	C562463	260350	HP:0002894	Identfication of key miRNAs in pancreatitis using bioinformatics analysis of microarray data.
tissue_expression_ns	hsa-mir-15a	Carcinoma, Pancreatic	27840954			C25.3	C562463	260350	HP:0002894	Identfication of key miRNAs in pancreatitis using bioinformatics analysis of microarray data.
tissue_expression_ns	hsa-mir-16	Carcinoma, Pancreatic	27840954			C25.3	C562463	260350	HP:0002894	Identfication of key miRNAs in pancreatitis using bioinformatics analysis of microarray data.
tissue_expression_ns	hsa-mir-375	Carcinoma, Pancreatic	27840954			C25.3	C562463	260350	HP:0002894	Identfication of key miRNAs in pancreatitis using bioinformatics analysis of microarray data.
tissue_expression_ns	hsa-mir-429	Carcinoma, Pancreatic	27840954			C25.3	C562463	260350	HP:0002894	Identfication of key miRNAs in pancreatitis using bioinformatics analysis of microarray data.
tissue_expression_ns	hsa-mir-196a	Carcinoma, Periampullary	24555977	disease of cellular proliferation	DOID:8110					Differentially expressed common miRNA signatures identified in PAC subgroups may have a role in pathogenesis of PAC and miR-375, miR-31 and miR-196a expression patterns may differentiate PAC subtypes.
tissue_expression_ns	hsa-mir-31	Carcinoma, Periampullary	24555977	disease of cellular proliferation	DOID:8110					Differentially expressed common miRNA signatures identified in PAC subgroups may have a role in pathogenesis of PAC and miR-375, miR-31 and miR-196a expression patterns may differentiate PAC subtypes.
tissue_expression_ns	hsa-mir-375	Carcinoma, Periampullary	24555977	disease of cellular proliferation	DOID:8110					Differentially expressed common miRNA signatures identified in PAC subgroups may have a role in pathogenesis of PAC and miR-375, miR-31 and miR-196a expression patterns may differentiate PAC subtypes.
tissue_expression_ns	hsa-let-7b	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-1179	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-1184	Carcinoma, Prostate	28072703	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	Screening the key microRNAs and transcription factors in prostate cancer based on microRNA functional synergistic relationships.
tissue_expression_ns	hsa-mir-1207	Carcinoma, Prostate	28072703	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	Screening the key microRNAs and transcription factors in prostate cancer based on microRNA functional synergistic relationships.
tissue_expression_ns	hsa-mir-1299	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-130a	Carcinoma, Prostate	27915273	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	Altered miRNA expression in high-fat diet-induced prostate cancer progression.
tissue_expression_ns	hsa-mir-145	Carcinoma, Prostate	28617988	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	MiR-145 detection in urinary extracellular vesicles increase diagnostic efficiency of prostate cancer based on hydrostatic filtration dialysis method.
tissue_expression_ns	hsa-mir-155	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-182	Carcinoma, Prostate	28072703	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	Screening the key microRNAs and transcription factors in prostate cancer based on microRNA functional synergistic relationships.
tissue_expression_ns	hsa-mir-183	Carcinoma, Prostate	28072703	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	Screening the key microRNAs and transcription factors in prostate cancer based on microRNA functional synergistic relationships.
tissue_expression_ns	hsa-mir-18a	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-19a	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-200a	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-21	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-221	Carcinoma, Prostate	27630329	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	to evaluate miR-23b, miR-26a and miR-221 expression levels in combination with preoperative serum PSA level to the risk of PCa recurrence after radical prostatectomy
tissue_expression_ns	hsa-mir-23b	Carcinoma, Prostate	27630329	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	to evaluate miR-23b, miR-26a and miR-221 expression levels in combination with preoperative serum PSA level to the risk of PCa recurrence after radical prostatectomy
tissue_expression_ns	hsa-mir-24	Carcinoma, Prostate	28072703	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	Screening the key microRNAs and transcription factors in prostate cancer based on microRNA functional synergistic relationships.
tissue_expression_ns	hsa-mir-26a	Carcinoma, Prostate	27630329	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	to evaluate miR-23b, miR-26a and miR-221 expression levels in combination with preoperative serum PSA level to the risk of PCa recurrence after radical prostatectomy
tissue_expression_ns	hsa-mir-30c	Carcinoma, Prostate	26499781	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	The average relative expressions of hsa-miR-203 and hsa-miR-30c in tumor tissues were significantly different from those in adjacent normal tissues
tissue_expression_ns	hsa-mir-3120	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-3149	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-3189	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-3622b	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-3677	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-3682	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-3689d	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-410	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-4469	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-4518	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-5189	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-639	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-92b	Carcinoma, Prostate	27903835	disease of cellular proliferation	DOID:10286	D07.5	D011471	176807	HP:0012125	the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer
tissue_expression_ns	hsa-mir-133b	Carcinoma, Rectal	16854228	disease of cellular proliferation	DOID:1993	C20	D012004			The analysis by several bioinformatics algorithms of colorectal tumours and adjacent non-neoplastic tissues from patients and colorectal cancer cell lines allowed identifying a group of 13 miRNA whose expression is significantly altered in this tumor. The most significantly deregulated miRNA being miR-31, miR-96, miR-133b, miR-135b, miR-145, and miR-183.
tissue_expression_ns	hsa-mir-135b	Carcinoma, Rectal	16854228	disease of cellular proliferation	DOID:1993	C20	D012004			The analysis by several bioinformatics algorithms of colorectal tumours and adjacent non-neoplastic tissues from patients and colorectal cancer cell lines allowed identifying a group of 13 miRNA whose expression is significantly altered in this tumor. The most significantly deregulated miRNA being miR-31, miR-96, miR-133b, miR-135b, miR-145, and miR-183.
tissue_expression_ns	hsa-mir-145	Carcinoma, Rectal	16854228	disease of cellular proliferation	DOID:1993	C20	D012004			The analysis by several bioinformatics algorithms of colorectal tumours and adjacent non-neoplastic tissues from patients and colorectal cancer cell lines allowed identifying a group of 13 miRNA whose expression is significantly altered in this tumor. The most significantly deregulated miRNA being miR-31, miR-96, miR-133b, miR-135b, miR-145, and miR-183.
tissue_expression_ns	hsa-mir-183	Carcinoma, Rectal	16854228	disease of cellular proliferation	DOID:1993	C20	D012004			The analysis by several bioinformatics algorithms of colorectal tumours and adjacent non-neoplastic tissues from patients and colorectal cancer cell lines allowed identifying a group of 13 miRNA whose expression is significantly altered in this tumor. The most significantly deregulated miRNA being miR-31, miR-96, miR-133b, miR-135b, miR-145, and miR-183.
tissue_expression_ns	hsa-mir-203	Carcinoma, Rectal	28403349	disease of cellular proliferation	DOID:1993	C20	D012004			Analysis of gene expression EGFR and KRAS, microRNA-21 and microRNA-203 in patients with colon and rectal cancer and correlation with clinical outcome and prognostic factors.
tissue_expression_ns	hsa-mir-21	Carcinoma, Rectal	20682703	disease of cellular proliferation	DOID:1993	C20	D012004			Although altered expressions of miR-21 and miR-34a were manifested within cancer cells, those of miR-126 and miR-155 were predominantly confined to endothelial cells and immune cells, respectively.
tissue_expression_ns	hsa-mir-21	Carcinoma, Rectal	28403349	disease of cellular proliferation	DOID:1993	C20	D012004			Analysis of gene expression EGFR and KRAS, microRNA-21 and microRNA-203 in patients with colon and rectal cancer and correlation with clinical outcome and prognostic factors.
tissue_expression_ns	hsa-mir-31	Carcinoma, Rectal	16854228	disease of cellular proliferation	DOID:1993	C20	D012004			The analysis by several bioinformatics algorithms of colorectal tumours and adjacent non-neoplastic tissues from patients and colorectal cancer cell lines allowed identifying a group of 13 miRNA whose expression is significantly altered in this tumor. The most significantly deregulated miRNA being miR-31, miR-96, miR-133b, miR-135b, miR-145, and miR-183.
tissue_expression_ns	hsa-mir-34a	Carcinoma, Rectal	20682703	disease of cellular proliferation	DOID:1993	C20	D012004			Although altered expressions of miR-21 and miR-34a were manifested within cancer cells, those of miR-126 and miR-155 were predominantly confined to endothelial cells and immune cells, respectively.
tissue_expression_ns	hsa-mir-92b	Carcinoma, Rectal	27601590	disease of cellular proliferation	DOID:1993	C20	D012004			Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis.
tissue_expression_ns	hsa-mir-96	Carcinoma, Rectal	16854228	disease of cellular proliferation	DOID:1993	C20	D012004			The analysis by several bioinformatics algorithms of colorectal tumours and adjacent non-neoplastic tissues from patients and colorectal cancer cell lines allowed identifying a group of 13 miRNA whose expression is significantly altered in this tumor. The most significantly deregulated miRNA being miR-31, miR-96, miR-133b, miR-135b, miR-145, and miR-183.
tissue_expression_ns	hsa-let-7c	Carcinoma, Renal Cell	23799849	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	MicroRNAs are able to accurately classify RCC samples. Deregulated miRNAs might contribute to the high chemotherapy resistance of RCC. Furthermore, our results indicate that pRCC type 2 tumours could be dependent on oncogenic MYC signalling.
tissue_expression_ns	hsa-mir-106a	Carcinoma, Renal Cell	24977165	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles.
tissue_expression_ns	hsa-mir-10b	Carcinoma, Renal Cell	22623952	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	The expression levels of miR-10b, miR-139-5p, miR-130b and miR-199b-5p could determine the status of ccRCC metastasis.
tissue_expression_ns	hsa-mir-126	Carcinoma, Renal Cell	22033272	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	The expression level of this miRNA was significantly altered in two independent cohorts of patients.
tissue_expression_ns	hsa-mir-126	Carcinoma, Renal Cell	24428907	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	A combined expression level of miR-21 and miR-126 accurately predicted CSS in two independent RCC cohorts and seems feasible for clinical application in assessing prognosis.
tissue_expression_ns	hsa-mir-130b	Carcinoma, Renal Cell	22623952	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	The expression levels of miR-10b, miR-139-5p, miR-130b and miR-199b-5p could determine the status of ccRCC metastasis.
tissue_expression_ns	hsa-mir-135a	Carcinoma, Renal Cell	24977165	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles.
tissue_expression_ns	hsa-mir-139	Carcinoma, Renal Cell	22623952	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	The expression levels of miR-10b, miR-139-5p, miR-130b and miR-199b-5p could determine the status of ccRCC metastasis.
tissue_expression_ns	hsa-mir-141	Carcinoma, Renal Cell	24129247	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Expression analysis of miR-141 or miR-200b accurately distinguished RCTs from normal renal tissues, oncocytoma from RCC and chRCC from oncocytoma. The diagnostic performance was confirmed in the validation set. Interestingly,miR-21, miR-141 and miR-155 expression levels showed prognostic significance in a univariate analysis.
tissue_expression_ns	hsa-mir-141	Carcinoma, Renal Cell	23635949	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Our recent studies of microRNA (miRNA) expression signatures demonstrated that the epithelial-mesenchymal transition (EMT)-related microRNA-200 family (miR-200s: miR-200a/b/c, miR-141 and miR-429) were significantly downregulated in renal cell carcinoma (RCC) and putative tumor-suppressive miRNAs in RCC.
tissue_expression_ns	hsa-mir-141	Carcinoma, Renal Cell	27357429	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	two types of cancer showed opposite expression patterns for miR-200 family miRNAs
tissue_expression_ns	hsa-mir-142	Carcinoma, Renal Cell	24977165	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles.
tissue_expression_ns	hsa-mir-145	Carcinoma, Renal Cell	23799849	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	MicroRNAs are able to accurately classify RCC samples. Deregulated miRNAs might contribute to the high chemotherapy resistance of RCC. Furthermore, our results indicate that pRCC type 2 tumours could be dependent on oncogenic MYC signalling.
tissue_expression_ns	hsa-mir-155	Carcinoma, Renal Cell	24129247	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Expression analysis of miR-141 or miR-200b accurately distinguished RCTs from normal renal tissues, oncocytoma from RCC and chRCC from oncocytoma. The diagnostic performance was confirmed in the validation set. Interestingly,miR-21, miR-141 and miR-155 expression levels showed prognostic significance in a univariate analysis.
tissue_expression_ns	hsa-mir-15a	Carcinoma, Renal Cell	29549624	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	MicroRNA-15a expression measured in urine samples as a potential biomarker of renal cell carcinoma.
tissue_expression_ns	hsa-mir-195	Carcinoma, Renal Cell	22623952	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	The expression levels of miR-10b, miR-139-5p, miR-130b and miR-199b-5p could determine the status of ccRCC metastasis.
tissue_expression_ns	hsa-mir-196a-1	Carcinoma, Renal Cell	22033272	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	The expression level of this miRNA was significantly altered in two independent cohorts of patients.
tissue_expression_ns	hsa-mir-199b	Carcinoma, Renal Cell	22623952	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	The expression levels of miR-10b, miR-139-5p, miR-130b and miR-199b-5p could determine the status of ccRCC metastasis.
tissue_expression_ns	hsa-mir-200	Carcinoma, Renal Cell	27357429	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	two types of cancer showed opposite expression patterns for miR-200 family miRNAs
tissue_expression_ns	hsa-mir-200a	Carcinoma, Renal Cell	23074016	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	The entire miR-200 seed family is strongly deregulated in clear cell renal cell cancer compared to the proximal tubular epithelial cells of the kidney
tissue_expression_ns	hsa-mir-200a	Carcinoma, Renal Cell	23635949	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Our recent studies of microRNA (miRNA) expression signatures demonstrated that the epithelial-mesenchymal transition (EMT)-related microRNA-200 family (miR-200s: miR-200a/b/c, miR-141 and miR-429) were significantly downregulated in renal cell carcinoma (RCC) and putative tumor-suppressive miRNAs in RCC.
tissue_expression_ns	hsa-mir-200a	Carcinoma, Renal Cell	27357429	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	two types of cancer showed opposite expression patterns for miR-200 family miRNAs
tissue_expression_ns	hsa-mir-200b	Carcinoma, Renal Cell	23074016	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	The entire miR-200 seed family is strongly deregulated in clear cell renal cell cancer compared to the proximal tubular epithelial cells of the kidney
tissue_expression_ns	hsa-mir-200b	Carcinoma, Renal Cell	23635949	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Our recent studies of microRNA (miRNA) expression signatures demonstrated that the epithelial-mesenchymal transition (EMT)-related microRNA-200 family (miR-200s: miR-200a/b/c, miR-141 and miR-429) were significantly downregulated in renal cell carcinoma (RCC) and putative tumor-suppressive miRNAs in RCC.
tissue_expression_ns	hsa-mir-200b	Carcinoma, Renal Cell	27357429	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	two types of cancer showed opposite expression patterns for miR-200 family miRNAs
tissue_expression_ns	hsa-mir-200b	Carcinoma, Renal Cell	29416756	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-126, miR-222 and miR-200b were significantly differentially expressed between the subtypes by in situ hybridization
tissue_expression_ns	hsa-mir-200c	Carcinoma, Renal Cell	23074016	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	The entire miR-200 seed family is strongly deregulated in clear cell renal cell cancer compared to the proximal tubular epithelial cells of the kidney
tissue_expression_ns	hsa-mir-200c	Carcinoma, Renal Cell	23799849	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	MicroRNAs are able to accurately classify RCC samples. Deregulated miRNAs might contribute to the high chemotherapy resistance of RCC. Furthermore, our results indicate that pRCC type 2 tumours could be dependent on oncogenic MYC signalling.
tissue_expression_ns	hsa-mir-200c	Carcinoma, Renal Cell	23635949	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Our recent studies of microRNA (miRNA) expression signatures demonstrated that the epithelial-mesenchymal transition (EMT)-related microRNA-200 family (miR-200s: miR-200a/b/c, miR-141 and miR-429) were significantly downregulated in renal cell carcinoma (RCC) and putative tumor-suppressive miRNAs in RCC.
tissue_expression_ns	hsa-mir-200c	Carcinoma, Renal Cell	27357429	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	two types of cancer showed opposite expression patterns for miR-200 family miRNAs
tissue_expression_ns	hsa-mir-204	Carcinoma, Renal Cell	22033272	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	The expression level of this miRNA was significantly altered in two independent cohorts of patients.
tissue_expression_ns	hsa-mir-206	Carcinoma, Renal Cell	24977165	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles.
tissue_expression_ns	hsa-mir-21	Carcinoma, Renal Cell	24428907	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	A combined expression level of miR-21 and miR-126 accurately predicted CSS in two independent RCC cohorts and seems feasible for clinical application in assessing prognosis.
tissue_expression_ns	hsa-mir-21	Carcinoma, Renal Cell	26729387	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Diagnostic and prognostic accuracy of miR-21 in renal cell carcinoma: a systematic review protocol.
tissue_expression_ns	hsa-mir-21	Carcinoma, Renal Cell	24977165	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles.
tissue_expression_ns	hsa-mir-21	Carcinoma, Renal Cell	24129247	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Expression analysis of miR-141 or miR-200b accurately distinguished RCTs from normal renal tissues, oncocytoma from RCC and chRCC from oncocytoma. The diagnostic performance was confirmed in the validation set. Interestingly,miR-21, miR-141 and miR-155 expression levels showed prognostic significance in a univariate analysis.
tissue_expression_ns	hsa-mir-210	Carcinoma, Renal Cell	23150176	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma
tissue_expression_ns	hsa-mir-210	Carcinoma, Renal Cell	23799849	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	MicroRNAs are able to accurately classify RCC samples. Deregulated miRNAs might contribute to the high chemotherapy resistance of RCC. Furthermore, our results indicate that pRCC type 2 tumours could be dependent on oncogenic MYC signalling.
tissue_expression_ns	hsa-mir-215	Carcinoma, Renal Cell	22033272	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	The expression level of this miRNA was significantly altered in two independent cohorts of patients. Overexpression of miR-215 decreased cellular migration and invasion in an RCC cell line model. In addition, through gene expression profiling, the authors identified direct and indirect targets of miR-215 that can contribute to tumour metastasis.
tissue_expression_ns	hsa-mir-216b	Carcinoma, Renal Cell	24977165	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles.
tissue_expression_ns	hsa-mir-221	Carcinoma, Renal Cell	29416756	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-126, miR-222 and miR-201b were significantly differentially expressed between the subtypes by in situ hybridization
tissue_expression_ns	hsa-mir-222	Carcinoma, Renal Cell	29416756	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-126, miR-222 and miR-202b were significantly differentially expressed between the subtypes by in situ hybridization
tissue_expression_ns	hsa-mir-2278	Carcinoma, Renal Cell	28099931	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	A new semisynthetic cardenolide analog 3β-2-(1-amantadine)- 1-on-ethylamine-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines.
tissue_expression_ns	hsa-mir-3065	Carcinoma, Renal Cell	24977165	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles.
tissue_expression_ns	hsa-mir-363	Carcinoma, Renal Cell	24977165	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles.
tissue_expression_ns	hsa-mir-429	Carcinoma, Renal Cell	23635949	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Our recent studies of microRNA (miRNA) expression signatures demonstrated that the epithelial-mesenchymal transition (EMT)-related microRNA-200 family (miR-200s: miR-200a/b/c, miR-141 and miR-429) were significantly downregulated in renal cell carcinoma (RCC) and putative tumor-suppressive miRNAs in RCC.
tissue_expression_ns	hsa-mir-489	Carcinoma, Renal Cell	24621579	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	New miRNA profiles accurately distinguish renal cell carcinomas and upper tract urothelial carcinomas from the normal kidney.
tissue_expression_ns	hsa-mir-502	Carcinoma, Renal Cell	23799849	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	MicroRNAs are able to accurately classify RCC samples. Deregulated miRNAs might contribute to the high chemotherapy resistance of RCC. Furthermore, our results indicate that pRCC type 2 tumours could be dependent on oncogenic MYC signalling.
tissue_expression_ns	hsa-mir-670	Carcinoma, Renal Cell	28099931	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	A new semisynthetic cardenolide analog 3β-2-(1-amantadine)- 1-on-ethylamine-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines.
tissue_expression_ns	hsa-mir-191	Carcinoma, Renal Cell, Chromophobe	25981392	disease of cellular proliferation	DOID:4471					mir-191, mir-19a, mir-210, and mir-425 miRNAs are expressed differentially in chRCC, and unique expression of miRNAs is associated with the progression and prognosis of chRCC.
tissue_expression_ns	hsa-mir-19a	Carcinoma, Renal Cell, Chromophobe	25981392	disease of cellular proliferation	DOID:4471					mir-191, mir-19a, mir-210, and mir-425 miRNAs are expressed differentially in chRCC, and unique expression of miRNAs is associated with the progression and prognosis of chRCC.
tissue_expression_ns	hsa-mir-210	Carcinoma, Renal Cell, Chromophobe	25981392	disease of cellular proliferation	DOID:4471					mir-191, mir-19a, mir-210, and mir-425 miRNAs are expressed differentially in chRCC, and unique expression of miRNAs is associated with the progression and prognosis of chRCC.
tissue_expression_ns	hsa-mir-425	Carcinoma, Renal Cell, Chromophobe	25981392	disease of cellular proliferation	DOID:4471					mir-191, mir-19a, mir-210, and mir-425 miRNAs are expressed differentially in chRCC, and unique expression of miRNAs is associated with the progression and prognosis of chRCC.
tissue_expression_ns	hsa-let-7a	Carcinoma, Renal Cell, Clear-Cell	28694731	disease of cellular proliferation	DOID:4467				HP:0006770	Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma.
tissue_expression_ns	hsa-let-7b	Carcinoma, Renal Cell, Clear-Cell	28694731	disease of cellular proliferation	DOID:4467				HP:0006770	Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma.
tissue_expression_ns	hsa-let-7d	Carcinoma, Renal Cell, Clear-Cell	28694731	disease of cellular proliferation	DOID:4467				HP:0006770	Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma.
tissue_expression_ns	hsa-let-7e	Carcinoma, Renal Cell, Clear-Cell	28694731	disease of cellular proliferation	DOID:4467				HP:0006770	Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma.
tissue_expression_ns	hsa-let-7g	Carcinoma, Renal Cell, Clear-Cell	24351440	disease of cellular proliferation	DOID:4467				HP:0006770	MicroRNA expression signatures of stage, grade, and progression in clear cell RCC.
tissue_expression_ns	hsa-let-7g	Carcinoma, Renal Cell, Clear-Cell	28694731	disease of cellular proliferation	DOID:4467				HP:0006770	Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma.
tissue_expression_ns	hsa-mir-122	Carcinoma, Renal Cell, Clear-Cell	28184927	disease of cellular proliferation	DOID:4467				HP:0006770	miR-122 and miR-34a, respectively, may regulate their expression in this cancer
tissue_expression_ns	hsa-mir-126	Carcinoma, Renal Cell, Clear-Cell	29202733	disease of cellular proliferation	DOID:4467				HP:0006770	Expression of micro-RNAs and genes related to angiogenesis in ccRCC and associations with tumor characteristics
tissue_expression_ns	hsa-mir-142	Carcinoma, Renal Cell, Clear-Cell	24351440	disease of cellular proliferation	DOID:4467				HP:0006770	MicroRNA expression signatures of stage, grade, and progression in clear cell RCC.
tissue_expression_ns	hsa-mir-200b	Carcinoma, Renal Cell, Clear-Cell	29202733	disease of cellular proliferation	DOID:4467				HP:0006770	Expression of micro-RNAs and genes related to angiogenesis in ccRCC and associations with tumor characteristics
tissue_expression_ns	hsa-mir-204	Carcinoma, Renal Cell, Clear-Cell	24351440	disease of cellular proliferation	DOID:4467				HP:0006770	MicroRNA expression signatures of stage, grade, and progression in clear cell RCC.
tissue_expression_ns	hsa-mir-21	Carcinoma, Renal Cell, Clear-Cell	24351440	disease of cellular proliferation	DOID:4467				HP:0006770	MicroRNA expression signatures of stage, grade, and progression in clear cell RCC.
tissue_expression_ns	hsa-mir-29a	Carcinoma, Renal Cell, Clear-Cell	25938468	disease of cellular proliferation	DOID:4467				HP:0006770	This study identified 11 commonly dysregulated miRNAs in ccRCC,three of which (miR-199a-5p, miR-22 and miR-429) may represent key miRNAs involved in the pathogenesis of ccRCC. Further studies suggested that miR-199a-5p plays an important role in inhibition of cell invasion of ccRCC cells by suppressing expression of TGFBR1 and JunB.
tissue_expression_ns	hsa-mir-34a	Carcinoma, Renal Cell, Clear-Cell	28184927	disease of cellular proliferation	DOID:4467				HP:0006770	Downregulation of OCLN and GAS1 in clear cell renal cell carcinoma.
tissue_expression_ns	hsa-mir-378	Carcinoma, Renal Cell, Clear-Cell	25119741	disease of cellular proliferation	DOID:4467				HP:0006770	The tumors of patients with ccRCC had lower  expression of miR-126 and miR-378 during the early stages of disease (T1), but higher expression of these miRNAs during the later stages of disease (T2/T3).
tissue_expression_ns	hsa-mir-424	Carcinoma, Renal Cell, Clear-Cell	24351440	disease of cellular proliferation	DOID:4467				HP:0006770	MicroRNA expression signatures of stage, grade, and progression in clear cell RCC.
tissue_expression_ns	hsa-mir-429	Carcinoma, Renal Cell, Clear-Cell	25938468	disease of cellular proliferation	DOID:4467				HP:0006770	This study identified 11 commonly dysregulated miRNAs in ccRCC,three of which (miR-199a-5p, miR-22 and miR-429) may represent key miRNAs involved in the pathogenesis of ccRCC. Further studies suggested that miR-199a-5p plays an important role in inhibition of cell invasion of ccRCC cells by suppressing expression of TGFBR1 and JunB.
tissue_expression_ns	hsa-mir-452	Carcinoma, Renal Cell, Clear-Cell	25938468	disease of cellular proliferation	DOID:4467				HP:0006770	This study identified 11 commonly dysregulated miRNAs in ccRCC,three of which (miR-199a-5p, miR-22 and miR-429) may represent key miRNAs involved in the pathogenesis of ccRCC. Further studies suggested that miR-199a-5p plays an important role in inhibition of cell invasion of ccRCC cells by suppressing expression of TGFBR1 and JunB.
tissue_expression_ns	hsa-mir-487a	Carcinoma, Renal Cell, Clear-Cell	25938468	disease of cellular proliferation	DOID:4467				HP:0006770	This study identified 11 commonly dysregulated miRNAs in ccRCC,three of which (miR-199a-5p, miR-22 and miR-429) may represent key miRNAs involved in the pathogenesis of ccRCC. Further studies suggested that miR-199a-5p plays an important role in inhibition of cell invasion of ccRCC cells by suppressing expression of TGFBR1 and JunB.
tissue_expression_ns	hsa-mir-491	Carcinoma, Renal Cell, Clear-Cell	25938468	disease of cellular proliferation	DOID:4467				HP:0006770	This study identified 11 commonly dysregulated miRNAs in ccRCC,three of which (miR-199a-5p, miR-22 and miR-429) may represent key miRNAs involved in the pathogenesis of ccRCC. Further studies suggested that miR-199a-5p plays an important role in inhibition of cell invasion of ccRCC cells by suppressing expression of TGFBR1 and JunB.
tissue_expression_ns	hsa-mir-532	Carcinoma, Renal Cell, Clear-Cell	25938468	disease of cellular proliferation	DOID:4467				HP:0006770	This study identified 11 commonly dysregulated miRNAs in ccRCC,three of which (miR-199a-5p, miR-22 and miR-429) may represent key miRNAs involved in the pathogenesis of ccRCC. Further studies suggested that miR-199a-5p plays an important role in inhibition of cell invasion of ccRCC cells by suppressing expression of TGFBR1 and JunB.
tissue_expression_ns	hsa-mir-1	Carcinoma, Skin	23646287	disease of cellular proliferation	DOID:3451	D04.9	D018280		HP:0008069	Differential expression of miR-1, a putative tumor suppressing microRNA, in cancer resistant and cancer susceptible mice.
tissue_expression_ns	hsa-mir-19a	Carcinoma, Supraglottic	24676647	disease of cellular proliferation	DOID:13476	C32.1	D059525			MicroRNA expression profiles in supraglottic carcinoma.
tissue_expression_ns	hsa-mir-206	Carcinoma, Supraglottic	24676647	disease of cellular proliferation	DOID:13476	C32.1	D059525			MicroRNA expression profiles in supraglottic carcinoma.
tissue_expression_ns	hsa-mir-21	Carcinoma, Supraglottic	24676647	disease of cellular proliferation	DOID:13476	C32.1	D059525			MicroRNA expression profiles in supraglottic carcinoma.
tissue_expression_ns	hsa-mir-33a	Carcinoma, Supraglottic	24676647	disease of cellular proliferation	DOID:13476	C32.1	D059525			MicroRNA expression profiles in supraglottic carcinoma.
tissue_expression_ns	hsa-mir-375	Carcinoma, Supraglottic	24676647	disease of cellular proliferation	DOID:13476	C32.1	D059525			MicroRNA expression profiles in supraglottic carcinoma.
tissue_expression_ns	hsa-let-7a	Carcinoma, Thyroid	28655518	disease of cellular proliferation	DOID:3963	C73	D013964	188550	HP:0002890	Effects of long non-coding RNA H19 and microRNA let7a expression on thyroid cancer prognosis.
tissue_expression_ns	hsa-mir-150	Carcinoma, Thyroid	24443580	disease of cellular proliferation	DOID:3963	C73	D013964	188550	HP:0002890	MicroRNA profile of poorly differentiated thyroid carcinomas: new diagnostic and prognostic insights.
tissue_expression_ns	hsa-mir-23b	Carcinoma, Thyroid	24443580	disease of cellular proliferation	DOID:3963	C73	D013964	188550	HP:0002890	MicroRNA profile of poorly differentiated thyroid carcinomas: new diagnostic and prognostic insights.
tissue_expression_ns	hsa-mir-10b	Carcinoma, Thyroid, Anaplastic	29397781			C73	D065646	188550	HP:0011779	These results demonstrate that IR deregulates microRNA expression, affecting the double-strand DNA breaks repair efficiency of irradiated thyroid cells, and suggest that miR-10b-5p overexpression may be an innovative approach for anaplastic thyroid cancer therapy by increasing cancer cell radiosensitivity.
tissue_expression_ns	hsa-mir-146b	Carcinoma, Thyroid, Follicular	24631480	disease of cellular proliferation	DOID:3962	C73	C572845	188470	HP:0006731	Differential miRNA expression defines migration and reduced apoptosis in follicular thyroid carcinomas.
tissue_expression_ns	hsa-mir-183	Carcinoma, Thyroid, Follicular	24631480	disease of cellular proliferation	DOID:3962	C73	C572845	188470	HP:0006731	Differential miRNA expression defines migration and reduced apoptosis in follicular thyroid carcinomas.
tissue_expression_ns	hsa-mir-199b	Carcinoma, Thyroid, Follicular	24631480	disease of cellular proliferation	DOID:3962	C73	C572845	188470	HP:0006731	Differential miRNA expression defines migration and reduced apoptosis in follicular thyroid carcinomas.
tissue_expression_ns	hsa-mir-221	Carcinoma, Thyroid, Follicular	24631480	disease of cellular proliferation	DOID:3962	C73	C572845	188470	HP:0006731	Differential miRNA expression defines migration and reduced apoptosis in follicular thyroid carcinomas.
tissue_expression_ns	hsa-mir-151a	Carcinoma, Thyroid, Medullary	27666315	disease of cellular proliferation	DOID:3973	C73	C536914	155240	HP:0002865	Selection and validation of miRNAs as normalizers for profiling expression of microRNAs isolated from thyroid fine needle aspiration smears.
tissue_expression_ns	hsa-mir-183	Carcinoma, Thyroid, Medullary	23072640	disease of cellular proliferation	DOID:3973	C73	C536914	155240	HP:0002865	This further validates previously reported miRNA profile analyses and reiterates the potential significance of miR-9*, -183 and -375 in the pathophysiology of MTC.
tissue_expression_ns	hsa-mir-197	Carcinoma, Thyroid, Medullary	27666315	disease of cellular proliferation	DOID:3973	C73	C536914	155240	HP:0002865	Selection and validation of miRNAs as normalizers for profiling expression of microRNAs isolated from thyroid fine needle aspiration smears.
tissue_expression_ns	hsa-mir-214	Carcinoma, Thyroid, Medullary	27666315	disease of cellular proliferation	DOID:3973	C73	C536914	155240	HP:0002865	Selection and validation of miRNAs as normalizers for profiling expression of microRNAs isolated from thyroid fine needle aspiration smears.
tissue_expression_ns	hsa-mir-375	Carcinoma, Thyroid, Medullary	23072640	disease of cellular proliferation	DOID:3973	C73	C536914	155240	HP:0002865	This further validates previously reported miRNA profile analyses and reiterates the potential significance of miR-9*, -183 and -375 in the pathophysiology of MTC.
tissue_expression_ns	hsa-mir-375	Carcinoma, Thyroid, Medullary	28861609	disease of cellular proliferation	DOID:3973	C73	C536914	155240	HP:0002865	MiR-375 and YAP1 expression profiling in medullary thyroid carcinoma and their correlation with clinical-pathological features and outcome.
tissue_expression_ns	hsa-mir-9	Carcinoma, Thyroid, Medullary	23072640	disease of cellular proliferation	DOID:3973	C73	C536914	155240	HP:0002865	This further validates previously reported miRNA profile analyses and reiterates the potential significance of miR-9*, -183 and -375 in the pathophysiology of MTC.
tissue_expression_ns	hsa-mir-99a	Carcinoma, Thyroid, Medullary	27666315	disease of cellular proliferation	DOID:3973	C73	C536914	155240	HP:0002865	Selection and validation of miRNAs as normalizers for profiling expression of microRNAs isolated from thyroid fine needle aspiration smears.
tissue_expression_ns	hsa-let-7a	Carcinoma, Thyroid, Papillary	25720323	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival.
tissue_expression_ns	hsa-mir-1179	Carcinoma, Thyroid, Papillary	25720323	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival.
tissue_expression_ns	hsa-mir-1179	Carcinoma, Thyroid, Papillary	28393181	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence
tissue_expression_ns	hsa-mir-1271	Carcinoma, Thyroid, Papillary	26414548	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations.
tissue_expression_ns	hsa-mir-130b	Carcinoma, Thyroid, Papillary	26414548	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations.
tissue_expression_ns	hsa-mir-135b	Carcinoma, Thyroid, Papillary	26414548	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations.
tissue_expression_ns	hsa-mir-140	Carcinoma, Thyroid, Papillary	28393181	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence
tissue_expression_ns	hsa-mir-144	Carcinoma, Thyroid, Papillary	28393181	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence
tissue_expression_ns	hsa-mir-146b	Carcinoma, Thyroid, Papillary	26414548	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations.
tissue_expression_ns	hsa-mir-146b	Carcinoma, Thyroid, Papillary	25771986	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Since miR-146b-5p was mainly expressed in PTC including FVPTC and was not expressed in most FTC, PDTC, or ATC, it may serve as a useful diagnostic  marker for PTC. ISH is a useful method to analyze microRNA expression in formalin-fixed paraffin-embedded thyroid tissues.
tissue_expression_ns	hsa-mir-146b	Carcinoma, Thyroid, Papillary	25720323	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival.
tissue_expression_ns	hsa-mir-146b	Carcinoma, Thyroid, Papillary	28393181	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence
tissue_expression_ns	hsa-mir-146b	Carcinoma, Thyroid, Papillary	20459574	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Hyalinizing trabecular tumour of the thyroid-differential expression of distinct miRNAs compared with papillary thyroid carcinoma.
tissue_expression_ns	hsa-mir-146b	Carcinoma, Thyroid, Papillary	21842215	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	miRNA profiling of hyalinizing trabecular tumours compared with benign thyroid lesions and papillary thyroid carcinoma failed to demonstrate the characteristic up-regulation found in papillary thyroid carcinoma
tissue_expression_ns	hsa-mir-146b	Carcinoma, Thyroid, Papillary	26321247	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	miRNA-222 and miRNA-146b deregulation are commonly associated with cancer recurrence in patients with papillary thyroid carcinoma.
tissue_expression_ns	hsa-mir-146b	Carcinoma, Thyroid, Papillary	28599426	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Dynamic monitoring of circulating microRNAs as a predictive biomarker for the diagnosis and recurrence of papillary thyroid carcinoma.
tissue_expression_ns	hsa-mir-151	Carcinoma, Thyroid, Papillary	26414548	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations.
tissue_expression_ns	hsa-mir-15a	Carcinoma, Thyroid, Papillary	26252081	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	We found that the area under the curve (AUC) values of 8 miRNAs (miR-106a, miR-15a, miR-30a, miR-30b, miR-20a, miR-20b, miR-30d and miR-30e)
tissue_expression_ns	hsa-mir-181-2	Carcinoma, Thyroid, Papillary	23427895	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Fourteen miRNAs were deregulated in FVPTC with a fold change of more than five (up/down), including miRNAs known to be upregulated in PTC (miR-146b-3p, -146-5p, -221, -222 and miR-222-5p) and novel miRNAs (miR-375, -551b, 181-2-3p, 99b-3p).
tissue_expression_ns	hsa-mir-181b	Carcinoma, Thyroid, Papillary	26414548	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations.
tissue_expression_ns	hsa-mir-181b	Carcinoma, Thyroid, Papillary	21842215	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	miRNA profiling of hyalinizing trabecular tumours compared with benign thyroid lesions and papillary thyroid carcinoma failed to demonstrate the characteristic up-regulation found in papillary thyroid carcinoma
tissue_expression_ns	hsa-mir-192	Carcinoma, Thyroid, Papillary	25720323	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival.
tissue_expression_ns	hsa-mir-199b	Carcinoma, Thyroid, Papillary	26414548	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations.
tissue_expression_ns	hsa-mir-204	Carcinoma, Thyroid, Papillary	25720323	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival.
tissue_expression_ns	hsa-mir-204	Carcinoma, Thyroid, Papillary	28393181	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence
tissue_expression_ns	hsa-mir-20a	Carcinoma, Thyroid, Papillary	26252081	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	We found that the area under the curve (AUC) values of 8 miRNAs (miR-106a, miR-15a, miR-30a, miR-30b, miR-20a, miR-20b, miR-30d and miR-30e)
tissue_expression_ns	hsa-mir-21	Carcinoma, Thyroid, Papillary	26414548	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations.
tissue_expression_ns	hsa-mir-21	Carcinoma, Thyroid, Papillary	25771986	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Since miR-146b-5p was mainly expressed in PTC including FVPTC and was not expressed in most FTC, PDTC, or ATC, it may serve as a useful diagnostic  marker for PTC. ISH is a useful method to analyze microRNA expression in formalin-fixed paraffin-embedded thyroid tissues.
tissue_expression_ns	hsa-mir-21	Carcinoma, Thyroid, Papillary	28393181	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence
tissue_expression_ns	hsa-mir-21	Carcinoma, Thyroid, Papillary	21842215	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	miRNA profiling of hyalinizing trabecular tumours compared with benign thyroid lesions and papillary thyroid carcinoma failed to demonstrate the characteristic up-regulation found in papillary thyroid carcinoma
tissue_expression_ns	hsa-mir-221	Carcinoma, Thyroid, Papillary	26414548	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations.
tissue_expression_ns	hsa-mir-221	Carcinoma, Thyroid, Papillary	25720323	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival.
tissue_expression_ns	hsa-mir-221	Carcinoma, Thyroid, Papillary	28393181	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence
tissue_expression_ns	hsa-mir-221	Carcinoma, Thyroid, Papillary	21842215	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	miRNA profiling of hyalinizing trabecular tumours compared with benign thyroid lesions and papillary thyroid carcinoma failed to demonstrate the characteristic up-regulation found in papillary thyroid carcinoma
tissue_expression_ns	hsa-mir-221	Carcinoma, Thyroid, Papillary	28599426	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Dynamic monitoring of circulating microRNAs as a predictive biomarker for the diagnosis and recurrence of papillary thyroid carcinoma.
tissue_expression_ns	hsa-mir-222	Carcinoma, Thyroid, Papillary	25720323	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival.
tissue_expression_ns	hsa-mir-222	Carcinoma, Thyroid, Papillary	26414548	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations.
tissue_expression_ns	hsa-mir-222	Carcinoma, Thyroid, Papillary	28393181	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence
tissue_expression_ns	hsa-mir-222	Carcinoma, Thyroid, Papillary	29435194	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	miRNA dysregulation and the risk of metastasis and invasion in papillary thyroid cancer: a systematic review and meta-analysis
tissue_expression_ns	hsa-mir-222	Carcinoma, Thyroid, Papillary	21842215	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	miRNA profiling of hyalinizing trabecular tumours compared with benign thyroid lesions and papillary thyroid carcinoma failed to demonstrate the characteristic up-regulation found in papillary thyroid carcinoma
tissue_expression_ns	hsa-mir-222	Carcinoma, Thyroid, Papillary	26321247	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	miRNA-222 and miRNA-146b deregulation are commonly associated with cancer recurrence in patients with papillary thyroid carcinoma.
tissue_expression_ns	hsa-mir-2861	Carcinoma, Thyroid, Papillary	26414548	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations.
tissue_expression_ns	hsa-mir-30a	Carcinoma, Thyroid, Papillary	26047355	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	The results of this study suggest that miR-30a-5p might be a novel diagnostic marker candidate in PTC. Further studies are required to investigate this possibility.
tissue_expression_ns	hsa-mir-30e	Carcinoma, Thyroid, Papillary	26252081	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	We found that the area under the curve (AUC) values of 8 miRNAs (miR-106a, miR-15a, miR-30a, miR-30b, miR-20a, miR-20b, miR-30d and miR-30e)
tissue_expression_ns	hsa-mir-34b	Carcinoma, Thyroid, Papillary	26414548	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations.
tissue_expression_ns	hsa-mir-375	Carcinoma, Thyroid, Papillary	23427895	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Fourteen miRNAs were deregulated in FVPTC with a fold change of more than five (up/down), including miRNAs known to be upregulated in PTC (miR-146b-3p, -146-5p, -221, -222 and miR-222-5p) and novel miRNAs (miR-375, -551b, 181-2-3p, 99b-3p).
tissue_expression_ns	hsa-mir-451	Carcinoma, Thyroid, Papillary	26414548	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations.
tissue_expression_ns	hsa-mir-486	Carcinoma, Thyroid, Papillary	28393181	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence
tissue_expression_ns	hsa-mir-551b	Carcinoma, Thyroid, Papillary	23427895	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Fourteen miRNAs were deregulated in FVPTC with a fold change of more than five (up/down), including miRNAs known to be upregulated in PTC (miR-146b-3p, -146-5p, -221, -222 and miR-222-5p) and novel miRNAs (miR-375, -551b, 181-2-3p, 99b-3p).
tissue_expression_ns	hsa-mir-623	Carcinoma, Thyroid, Papillary	26414548	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations.
tissue_expression_ns	hsa-mir-7	Carcinoma, Thyroid, Papillary	25720323	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival.
tissue_expression_ns	hsa-mir-7	Carcinoma, Thyroid, Papillary	28393181	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence
tissue_expression_ns	hsa-mir-99b	Carcinoma, Thyroid, Papillary	23427895	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Fourteen miRNAs were deregulated in FVPTC with a fold change of more than five (up/down), including miRNAs known to be upregulated in PTC (miR-146b-3p, -146-5p, -221, -222 and miR-222-5p) and novel miRNAs (miR-375, -551b, 181-2-3p, 99b-3p).
tissue_expression_ns	hsa-mir-183	Carcinoma, Tounge	28616749							miR-183 and miR-21 expression as biomarkers of progression and survival in tongue carcinoma patients.
tissue_expression_ns	hsa-mir-21	Carcinoma, Tounge	28616749							miR-183 and miR-21 expression as biomarkers of progression and survival in tongue carcinoma patients.
tissue_expression_ns	hsa-mir-630	Carcinoma, Urothelial	27752905	disease of cellular proliferation	DOID:4006				HP:0030409	Expression of miRNA-630 in bladder urothelial carcinoma and its clinical significance.
tissue_expression_ns	hsa-mir-181c	Carcinoma, Urothelial, Upper Tract	26397152							Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo.
tissue_expression_ns	hsa-mir-330	Carcinoma, Urothelial, Upper Tract	26397152							Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo.
tissue_expression_ns	hsa-mir-3916	Carcinoma, Urothelial, Upper Tract	26397152							Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo.
tissue_expression_ns	hsa-mir-4274	Carcinoma, Urothelial, Upper Tract	26397152							Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo.
tissue_expression_ns	hsa-mir-4784	Carcinoma, Urothelial, Upper Tract	26397152							Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo.
tissue_expression_ns	hsa-mir-4795	Carcinoma, Urothelial, Upper Tract	26397152							Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo.
tissue_expression_ns	hsa-mir-488	Carcinoma, Urothelial, Upper Tract	26397152							Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo.
tissue_expression_ns	hsa-mir-1	Cardiomegaly	20015039			I51.7	D006332		HP:0001640	Lately, some highlight articles revealed that the altered expression of miRNAs such as miR-1, miR-133, miR-21, miR-208 etc in hearts also contributed to cardiovascular diseases, such as heart ischemia, cardiac hypertrophy, and arrhythmias.
tissue_expression_ns	hsa-mir-21	Cardiomegaly	20015039			I51.7	D006332		HP:0001640	Lately, some highlight articles revealed that the altered expression of miRNAs such as miR-1, miR-133, miR-21, miR-208 etc in hearts also contributed to cardiovascular diseases, such as heart ischemia, cardiac hypertrophy, and arrhythmias.
tissue_expression_ns	hsa-mir-200	Cardiomyopathy	27737314	cardiovascular system disease	DOID:0050700	I42	D009202			Analyzing gene expression profiles in dilated cardiomyopathy via bioinformatics methods.
tissue_expression_ns	hsa-mir-30	Cardiomyopathy	27737314	cardiovascular system disease	DOID:0050700	I42	D009202			Analyzing gene expression profiles in dilated cardiomyopathy via bioinformatics methods.
tissue_expression_ns	hsa-mir-9	Cardiomyopathy	27737314	cardiovascular system disease	DOID:0050700	I42	D009202			Analyzing gene expression profiles in dilated cardiomyopathy via bioinformatics methods.
tissue_expression_ns	hsa-mir-10a	Cardiomyopathy, Hypertrophic	24083979	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways.
tissue_expression_ns	hsa-mir-10b	Cardiomyopathy, Hypertrophic	24083979	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways.
tissue_expression_ns	hsa-mir-181a-2	Cardiomyopathy, Hypertrophic	24083979	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways.
tissue_expression_ns	hsa-mir-184	Cardiomyopathy, Hypertrophic	24083979	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways.
tissue_expression_ns	hsa-mir-204	Cardiomyopathy, Hypertrophic	24083979	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways.
tissue_expression_ns	hsa-mir-222	Cardiomyopathy, Hypertrophic	24083979	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways.
tissue_expression_ns	hsa-mir-34b	Cardiomyopathy, Hypertrophic	24083979	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways.
tissue_expression_ns	hsa-mir-371	Cardiomyopathy, Hypertrophic	24083979	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways.
tissue_expression_ns	hsa-mir-383	Cardiomyopathy, Hypertrophic	24083979	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways.
tissue_expression_ns	hsa-mir-497	Cardiomyopathy, Hypertrophic	24083979	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways.
tissue_expression_ns	hsa-mir-708	Cardiomyopathy, Hypertrophic	24083979	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways.
tissue_expression_ns	hsa-mir-96	Cardiomyopathy, Hypertrophic	24083979	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways.
tissue_expression_ns	hsa-mir-130a	Cardiotoxicity	27033315				D066126			We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin.
tissue_expression_ns	hsa-mir-146a	Cardiotoxicity	27033315				D066126			We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin.
tissue_expression_ns	hsa-mir-15b	Cardiotoxicity	27033315				D066126			We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin.
tissue_expression_ns	hsa-mir-187	Cardiotoxicity	27033315				D066126			We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin.
tissue_expression_ns	hsa-mir-199a	Cardiotoxicity	27033315				D066126			We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin.
tissue_expression_ns	hsa-mir-199b	Cardiotoxicity	27033315				D066126			We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin.
tissue_expression_ns	hsa-mir-214	Cardiotoxicity	27033315				D066126			We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin.
tissue_expression_ns	hsa-mir-34a	Cardiotoxicity	27033315				D066126			We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin.
tissue_expression_ns	hsa-mir-34b	Cardiotoxicity	27033315				D066126			We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin.
tissue_expression_ns	hsa-mir-424	Cardiotoxicity	27033315				D066126			We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin.
tissue_expression_ns	hsa-mir-133a	Cardiovascular Diseases [unspecific]	27765794				D002318			Inhibition of Aberrant MicroRNA-133a Expression in Endothelial Cells by Statin Prevents Endothelial Dysfunction by Targeting GTP Cyclohydrolase 1 in Vivo.
tissue_expression_ns	hsa-mir-155	Cardiovascular Diseases [unspecific]	25978529				D002318			microRNA expression patterns have a low diagnostic potential clinically in discriminating DCD liver quality and outcome.
tissue_expression_ns	hsa-mir-21	Cardiovascular Diseases [unspecific]	28802862				D002318			MicroRNA-21: Expression in oligodendrocytes and correlation with low myelin mRNAs in depression and alcoholism.
tissue_expression_ns	hsa-mir-22	Cardiovascular Diseases [unspecific]	25978529				D002318			microRNA expression patterns have a low diagnostic potential clinically in discriminating DCD liver quality and outcome.
tissue_expression_ns	hsa-mir-24	Cardiovascular Diseases [unspecific]	27108908				D002318			The dysregulation of miR-24 is associated with dysfunction or even damage of VECs, and contributes to the development of cardiovascular disease.
tissue_expression_ns	hsa-mir-940	Cardiovascular Diseases [unspecific]	25978529				D002318			microRNA expression patterns have a low diagnostic potential clinically in discriminating DCD liver quality and outcome.
tissue_expression_ns	hsa-mir-9	Cerebral Aneurysm	27824808	cardiovascular system disease	DOID:0060228	I67.1	D002532	PS105800	HP:0007029	Aberrant Expression of microRNA-9 Contributes to Development of Intracranial Aneurysm by Suppressing Proliferation and Reducing Contractility of Smooth Muscle Cells.
tissue_expression_ns	hsa-let-7i	Cerebral Malaria	21422175	disease by infectious agent	DOID:14069	B50.0	D016779			We identified three miRNAs that were differentially expressed in the brain of PbA-infected CBA mice: let7i, miR-27a, and miR-150.
tissue_expression_ns	hsa-mir-150	Cerebral Malaria	21422175	disease by infectious agent	DOID:14069	B50.0	D016779			We identified three miRNAs that were differentially expressed in the brain of PbA-infected CBA mice: let7i, miR-27a, and miR-150.
tissue_expression_ns	hsa-mir-27a	Cerebral Malaria	21422175	disease by infectious agent	DOID:14069	B50.0	D016779			We identified three miRNAs that were differentially expressed in the brain of PbA-infected CBA mice: let7i, miR-27a, and miR-150.
tissue_expression_ns	hsa-mir-126	Cholangiocarcinoma	23458262	disease of cellular proliferation	DOID:4947	C22.1	D018281	615619	HP:0030153	Concomitant dysregulation of microRNAs miR-151-3p and miR-126 correlates with improved survival in resected cholangiocarcinoma
tissue_expression_ns	hsa-mir-151	Cholangiocarcinoma	23458262	disease of cellular proliferation	DOID:4947	C22.1	D018281	615619	HP:0030153	Concomitant dysregulation of microRNAs miR-151-3p and miR-126 correlates with improved survival in resected cholangiocarcinoma
tissue_expression_ns	hsa-mir-138	Chondrosarcoma	27267924	disease of cellular proliferation	DOID:3371	M91-M94	D002813	215300	HP:0006765	increased expression of two microRNAs, miRs-181a and -138, in low-grade chondrosarcomas compared with enchondromas
tissue_expression_ns	hsa-mir-149	Chordoma	23826111	musculoskeletal system disease	DOID:3302	C41.0	D002817	215400	HP:0010762	This study provides an integrated dataset of the miRNA and mRNA profiles in chordomas, and the results demonstrate that not only the MAPK pathway and its related miRNAs but also the Notch pathway may be involved in chordoma development. The occurrence of chordoma may be associated with dysfunctional calcification or ossification of the notochord.
tissue_expression_ns	hsa-mir-1908	Chordoma	23826111	musculoskeletal system disease	DOID:3302	C41.0	D002817	215400	HP:0010762	This study provides an integrated dataset of the miRNA and mRNA profiles in chordomas, and the results demonstrate that not only the MAPK pathway and its related miRNAs but also the Notch pathway may be involved in chordoma development. The occurrence of chordoma may be associated with dysfunctional calcification or ossification of the notochord.
tissue_expression_ns	hsa-mir-2861	Chordoma	23826111	musculoskeletal system disease	DOID:3302	C41.0	D002817	215400	HP:0010762	This study provides an integrated dataset of the miRNA and mRNA profiles in chordomas, and the results demonstrate that not only the MAPK pathway and its related miRNAs but also the Notch pathway may be involved in chordoma development. The occurrence of chordoma may be associated with dysfunctional calcification or ossification of the notochord.
tissue_expression_ns	hsa-mir-3185	Chordoma	23826111	musculoskeletal system disease	DOID:3302	C41.0	D002817	215400	HP:0010762	This study provides an integrated dataset of the miRNA and mRNA profiles in chordomas, and the results demonstrate that not only the MAPK pathway and its related miRNAs but also the Notch pathway may be involved in chordoma development. The occurrence of chordoma may be associated with dysfunctional calcification or ossification of the notochord.
tissue_expression_ns	hsa-mir-663a	Chordoma	23826111	musculoskeletal system disease	DOID:3302	C41.0	D002817	215400	HP:0010762	This study provides an integrated dataset of the miRNA and mRNA profiles in chordomas, and the results demonstrate that not only the MAPK pathway and its related miRNAs but also the Notch pathway may be involved in chordoma development. The occurrence of chordoma may be associated with dysfunctional calcification or ossification of the notochord.
tissue_expression_ns	hsa-mir-194	Choriocarcinoma	26578390	disease of cellular proliferation	DOID:3594	C58	D002822		HP:0100768	we found hsa-miR-194 and  hsa-miR-7 along with 7 transcription factors (TFs) such as SOX11, SMAD3 and SOX4  etc. could correctly differentiate SPN from PanNET
tissue_expression_ns	hsa-mir-203	Choriocarcinoma	20652642	disease of cellular proliferation	DOID:3594	C58	D002822		HP:0100768	miR-203 expression is a new prognostic marker in pancreatic adenocarcinoma patients.
tissue_expression_ns	hsa-mir-204	Choriocarcinoma	26578390	disease of cellular proliferation	DOID:3594	C58	D002822		HP:0100768	while hsa-miR-204 and 4 TFs such as SOX9, TCF7 and PPARD etc. were demonstrated as the potential markers for  SPN versus PDAC.
tissue_expression_ns	hsa-mir-21	Choriocarcinoma	26338526	disease of cellular proliferation	DOID:3594	C58	D002822		HP:0100768	Statistical analysis of a Bayesian classifier based on the expression of miRNAs.
tissue_expression_ns	hsa-mir-1238	Chronic Brucellosis	27722176			A23	D002006			Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis.
tissue_expression_ns	hsa-mir-139	Chronic Brucellosis	27722176			A23	D002006			Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis.
tissue_expression_ns	hsa-mir-494	Chronic Brucellosis	27722176			A23	D002006			Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis.
tissue_expression_ns	hsa-mir-6069	Chronic Brucellosis	27722176			A23	D002006			Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis.
tissue_expression_ns	hsa-mir-146a	Chronic Hepatitis C	27888401			B18.2	D019698	609532		The impact of chronic hepatitis C infection on cholesterol metabolism in PBMCs is associated with microRNA-146a expression.
tissue_expression_ns	hsa-mir-106b	Chronic Kidney Disease	28148896	urinary system disease	DOID:784	N18.9	D007676		HP:0012622	Investigated the safety of intra-renal arterial transfusion of autologous CD34+ cells and time courses of creatinine levels, endothelial dysfunction biomarkers and micro-RNAs in chronic kidney disease patients-phase I clinical trial.
tissue_expression_ns	hsa-mir-107	Chronic Kidney Disease	21794090	urinary system disease	DOID:784	N18.9	D007676		HP:0012622	Differential expression was detected for miR-142-3p, miR-204, miR-107 and miR-211 (p < 0.001) and miR-32 (p < 0.05).
tissue_expression_ns	hsa-mir-142	Chronic Kidney Disease	21794090	urinary system disease	DOID:784	N18.9	D007676		HP:0012622	Differential expression was detected for miR-142-3p, miR-204, miR-107 and miR-211 (p < 0.001) and miR-32 (p < 0.05). Furthermore, differential expression of miR-142-3p (p < 0.01), miR-204 (p < 0.01) and miR-211 (p < 0.05) was also observed between patient groups in urine samples.
tissue_expression_ns	hsa-mir-19a	Chronic Kidney Disease	28148896	urinary system disease	DOID:784	N18.9	D007676		HP:0012622	Investigated the safety of intra-renal arterial transfusion of autologous CD34+ cells and time courses of creatinine levels, endothelial dysfunction biomarkers and micro-RNAs in chronic kidney disease patients-phase I clinical trial.
tissue_expression_ns	hsa-mir-204	Chronic Kidney Disease	21794090	urinary system disease	DOID:784	N18.9	D007676		HP:0012622	Differential expression was detected for miR-142-3p, miR-204, miR-107 and miR-211 (p < 0.001) and miR-32 (p < 0.05). Furthermore, differential expression of miR-142-3p (p < 0.01), miR-204 (p < 0.01) and miR-211 (p < 0.05) was also observed between patient groups in urine samples.
tissue_expression_ns	hsa-mir-20a	Chronic Kidney Disease	28148896	urinary system disease	DOID:784	N18.9	D007676		HP:0012622	Investigated the safety of intra-renal arterial transfusion of autologous CD34+ cells and time courses of creatinine levels, endothelial dysfunction biomarkers and micro-RNAs in chronic kidney disease patients-phase I clinical trial.
tissue_expression_ns	hsa-mir-211	Chronic Kidney Disease	21794090	urinary system disease	DOID:784	N18.9	D007676		HP:0012622	Differential expression was detected for miR-142-3p, miR-204, miR-107 and miR-211 (p < 0.001) and miR-32 (p < 0.05). Furthermore, differential expression of miR-142-3p (p < 0.01), miR-204 (p < 0.01) and miR-211 (p < 0.05) was also observed between patient groups in urine samples.
tissue_expression_ns	hsa-mir-26b	Chronic Kidney Disease	28148896	urinary system disease	DOID:784	N18.9	D007676		HP:0012622	Investigated the safety of intra-renal arterial transfusion of autologous CD34+ cells and time courses of creatinine levels, endothelial dysfunction biomarkers and micro-RNAs in chronic kidney disease patients-phase I clinical trial.
tissue_expression_ns	hsa-mir-32	Chronic Kidney Disease	21794090	urinary system disease	DOID:784	N18.9	D007676		HP:0012622	Differential expression was detected for miR-142-3p, miR-204, miR-107 and miR-211 (p < 0.001) and miR-32 (p < 0.05).
tissue_expression_ns	hsa-mir-374a	Chronic Kidney Disease	28148896	urinary system disease	DOID:784	N18.9	D007676		HP:0012622	Investigated the safety of intra-renal arterial transfusion of autologous CD34+ cells and time courses of creatinine levels, endothelial dysfunction biomarkers and micro-RNAs in chronic kidney disease patients-phase I clinical trial.
tissue_expression_ns	hsa-let-7a	Chronic Obstructive Pulmonary Disease	29371906	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-let-7c	Chronic Obstructive Pulmonary Disease	29371906	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-mir-126	Chronic Obstructive Pulmonary Disease	29371906	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-mir-155	Chronic Obstructive Pulmonary Disease	29371906	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-mir-200b	Chronic Obstructive Pulmonary Disease	29371906	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-mir-21	Chronic Obstructive Pulmonary Disease	29371906	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-mir-210	Chronic Obstructive Pulmonary Disease	29371906	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-mir-30a	Chronic Obstructive Pulmonary Disease	29371906	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-mir-451	Chronic Obstructive Pulmonary Disease	29371906	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-mir-198	Chronic Pancreatitis	25908274			K86.1	D050500	167800	HP:0006280	Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-21	Chronic Pancreatitis	25908274			K86.1	D050500	167800	HP:0006280	Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-217	Chronic Pancreatitis	25908274			K86.1	D050500	167800	HP:0006280	Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-mir-34a	Chronic Pancreatitis	25908274			K86.1	D050500	167800	HP:0006280	Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma.
tissue_expression_ns	hsa-let-7e	Colitis, Ulcerative	23885139	gastrointestinal system disease	DOID:8577	K51	D003093			The present study provides the first evidence that miR-20b, miR-98, miR-125b-1*, and let-7e* are deregulated in patients with UC.
tissue_expression_ns	hsa-let-7c	Colon Neoplasms	29844680			D12.6	D003110		HP:0100273	five hub miRNAs were identified to be related to prognosis (hsa-miR-125b-5p, hsa-miR-145-5p, hsa-let-7c-5p, hsa-miR-218-5p and hsa-miR-125b-2-3p)
tissue_expression_ns	hsa-mir-125b	Colon Neoplasms	29844680			D12.6	D003110		HP:0100273	five hub miRNAs were identified to be related to prognosis (hsa-miR-125b-5p, hsa-miR-145-5p, hsa-let-7c-5p, hsa-miR-218-5p and hsa-miR-125b-2-3p)
tissue_expression_ns	hsa-mir-138	Colon Neoplasms	24941171			D12.6	D003110		HP:0100273	This is the first to reveal the importance of aberrant expression of miRNAs in dynamically transformation from chronic colitis to colitis-associated cancer. These findings shed light on revealing the mechanisms of chronic colitis malignant transformation.
tissue_expression_ns	hsa-mir-138	Colon Neoplasms	24732966			D12.6	D003110		HP:0100273	miRs including mir-425, mir-196, mir-155, mir-150, mir-351, mir-16, let-7, mir34, and  mir-138 were differentially expressed between the dietary groups.
tissue_expression_ns	hsa-mir-143	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-145	Colon Neoplasms	24941171			D12.6	D003110		HP:0100273	This is the first to reveal the importance of aberrant expression of miRNAs in dynamically transformation from chronic colitis to colitis-associated cancer. These findings shed light on revealing the mechanisms of chronic colitis malignant transformation.
tissue_expression_ns	hsa-mir-145	Colon Neoplasms	29844680			D12.6	D003110		HP:0100273	five hub miRNAs were identified to be related to prognosis (hsa-miR-125b-5p, hsa-miR-145-5p, hsa-let-7c-5p, hsa-miR-218-5p and hsa-miR-125b-2-3p)
tissue_expression_ns	hsa-mir-146a	Colon Neoplasms	24941171			D12.6	D003110		HP:0100273	This is the first to reveal the importance of aberrant expression of miRNAs in dynamically transformation from chronic colitis to colitis-associated cancer. These findings shed light on revealing the mechanisms of chronic colitis malignant transformation.
tissue_expression_ns	hsa-mir-146a	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-148a	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-150	Colon Neoplasms	24941171			D12.6	D003110		HP:0100273	This is the first to reveal the importance of aberrant expression of miRNAs in dynamically transformation from chronic colitis to colitis-associated cancer. These findings shed light on revealing the mechanisms of chronic colitis malignant transformation.
tissue_expression_ns	hsa-mir-150	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-181a	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-196a	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-203	Colon Neoplasms	26397233			D12.6	D003110		HP:0100273	Cumulatively,our data purport that p53 not only increased Puma expression directly, but that it may also do so through miR-203. Additionally, functional studies revealed that miR-203 overexpression induced apoptosis and inhibited cell invasiveness.
tissue_expression_ns	hsa-mir-210	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-218	Colon Neoplasms	29844680			D12.6	D003110		HP:0100273	five hub miRNAs were identified to be related to prognosis (hsa-miR-125b-5p, hsa-miR-145-5p, hsa-let-7c-5p, hsa-miR-218-5p and hsa-miR-125b-2-3p)
tissue_expression_ns	hsa-mir-221	Colon Neoplasms	25075256			D12.6	D003110		HP:0100273	Five miRNAs (miR-203-3p, miR-221-3p, miR-342-3p, miR-491-5p and miR-503-5p) were dysregulated in colon cancer tissue (P < 0.05).
tissue_expression_ns	hsa-mir-222	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-223	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-23a	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-25	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-27a	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-30b	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-30c	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-30d	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-31	Colon Neoplasms	29152124			D12.6	D003110		HP:0100273	The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p
tissue_expression_ns	hsa-mir-1	Colorectal Adenocarcinoma	25803870	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma.
tissue_expression_ns	hsa-mir-135b	Colorectal Adenocarcinoma	25803870	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma.
tissue_expression_ns	hsa-mir-145	Colorectal Adenocarcinoma	25803870	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma.
tissue_expression_ns	hsa-mir-3195	Colorectal Adenocarcinoma	25803870	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma.
tissue_expression_ns	hsa-mir-429	Colorectal Adenocarcinoma	25803870	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma.
tissue_expression_ns	hsa-mir-4469	Colorectal Adenocarcinoma	25803870	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma.
tissue_expression_ns	hsa-mir-4510	Colorectal Adenocarcinoma	25803870	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma.
tissue_expression_ns	hsa-mir-4770	Colorectal Adenocarcinoma	25803870	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma.
tissue_expression_ns	hsa-mir-549	Colorectal Adenocarcinoma	25803870	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma.
tissue_expression_ns	hsa-mir-552	Colorectal Adenocarcinoma	25803870	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma.
tissue_expression_ns	hsa-mir-96	Colorectal Adenocarcinoma	25803870	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma.
tissue_expression_ns	hsa-mir-99b	Colorectal Adenocarcinoma	25803870	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma.
tissue_expression_ns	hsa-mir-125a	Colorectal Adenoma	25586944	disease of cellular proliferation	DOID:0050860					several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer.
tissue_expression_ns	hsa-mir-145	Colorectal Adenoma	25586944	disease of cellular proliferation	DOID:0050860					several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer.
tissue_expression_ns	hsa-mir-15b	Colorectal Adenoma	25586944	disease of cellular proliferation	DOID:0050860					several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer.
tissue_expression_ns	hsa-mir-16	Colorectal Adenoma	25586944	disease of cellular proliferation	DOID:0050860					several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer.
tissue_expression_ns	hsa-mir-21	Colorectal Adenoma	25586944	disease of cellular proliferation	DOID:0050860					several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer.
tissue_expression_ns	hsa-mir-24	Colorectal Adenoma	25586944	disease of cellular proliferation	DOID:0050860					several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer.
tissue_expression_ns	hsa-mir-320	Colorectal Adenoma	25586944	disease of cellular proliferation	DOID:0050860					several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer.
tissue_expression_ns	hsa-mir-320b	Colorectal Adenoma	25586944	disease of cellular proliferation	DOID:0050860					several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer.
tissue_expression_ns	hsa-mir-378	Colorectal Adenoma	25586944	disease of cellular proliferation	DOID:0050860					several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer.
tissue_expression_ns	hsa-let-7g	Colorectal Carcinoma	23932154	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.
tissue_expression_ns	hsa-mir-1	Colorectal Carcinoma	26045793	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The potential value of miR-1 and miR-374b as biomarkers for colorectal cancer.
tissue_expression_ns	hsa-mir-100	Colorectal Carcinoma	26714601	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression of miR-100 is correlated with lymph node metastasis, TNM stage and differentiation grade, and may be a potential biomarker indicating the development of CRC.
tissue_expression_ns	hsa-mir-106	Colorectal Carcinoma	24078989	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiRNAs might soon represent novel prognostic and diagnostic tools in patients at high risk of CRC or being diagnosed with CRC.
tissue_expression_ns	hsa-mir-106a	Colorectal Carcinoma	25773836	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.
tissue_expression_ns	hsa-mir-106b	Colorectal Carcinoma	23690963	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples.
tissue_expression_ns	hsa-mir-10b	Colorectal Carcinoma	28289479	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Colorectal adenoma and carcinoma specific miRNA profiles in biopsy and their expression in plasma specimens.
tissue_expression_ns	hsa-mir-1246	Colorectal Carcinoma	27916938	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells.
tissue_expression_ns	hsa-mir-125	Colorectal Carcinoma	27775664	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival.
tissue_expression_ns	hsa-mir-126	Colorectal Carcinoma	25592646	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The intra-tumoural expression of EGFL7 in early stages of CRC may influence the risk of post-surgical recurrence. Differential expression of miRNA-126 seems more pronounced in disseminated disease, which supports its role as a regulator in the metastatic process.
tissue_expression_ns	hsa-mir-126	Colorectal Carcinoma	26455548	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		To conclude, deregulation of miR-126 in colorectal cancer at the tissue and cellular levels as well as its correlation with various clinicopathological parameters confirm the cancer suppressive role of miR-126 in colorectal cancer.
tissue_expression_ns	hsa-mir-126	Colorectal Carcinoma	24078989	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiRNAs might soon represent novel prognostic and diagnostic tools in patients at high risk of CRC or being diagnosed with CRC.
tissue_expression_ns	hsa-mir-127	Colorectal Carcinoma	25773836	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.
tissue_expression_ns	hsa-mir-127	Colorectal Carcinoma	27775664	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival.
tissue_expression_ns	hsa-mir-1290	Colorectal Carcinoma	27916938	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells.
tissue_expression_ns	hsa-mir-132	Colorectal Carcinoma	23932154	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.
tissue_expression_ns	hsa-mir-133a	Colorectal Carcinoma	25773836	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.
tissue_expression_ns	hsa-mir-133a	Colorectal Carcinoma	23690963	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples.
tissue_expression_ns	hsa-mir-133b	Colorectal Carcinoma	25773836	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.
tissue_expression_ns	hsa-mir-135b	Colorectal Carcinoma	25773836	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.
tissue_expression_ns	hsa-mir-135b	Colorectal Carcinoma	23568010	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		our results are contradictory to previous studies performed on the CRC patients from Chinese population, providing an evidence against usage of serum miR-17-3p, miR-29a, miR-92a and miR-135b as new biomarkers for early detection of CRC
tissue_expression_ns	hsa-mir-135b	Colorectal Carcinoma	27672263	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MicroRNA biomarkers predicting risk, initiation and progression of colorectal cancer.
tissue_expression_ns	hsa-mir-139	Colorectal Carcinoma	26462034	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation.
tissue_expression_ns	hsa-mir-141	Colorectal Carcinoma	24510588	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-200a, miR-200c, miR-141, and miR-429 expression levels may identify CRC patients, including those with stage II disease, who are most likely to benefit from adjuvant chemotherapy.
tissue_expression_ns	hsa-mir-143	Colorectal Carcinoma	25773836	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.
tissue_expression_ns	hsa-mir-143	Colorectal Carcinoma	26462034	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation.
tissue_expression_ns	hsa-mir-143	Colorectal Carcinoma	23690963	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples.
tissue_expression_ns	hsa-mir-145	Colorectal Carcinoma	25773836	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.
tissue_expression_ns	hsa-mir-145	Colorectal Carcinoma	26462034	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation.
tissue_expression_ns	hsa-mir-145	Colorectal Carcinoma	26335822	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The analysis of microRNAs miR-200C and miR-145 expression in colorectal cancer of different molecular subtypes.
tissue_expression_ns	hsa-mir-145	Colorectal Carcinoma	23690963	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples.
tissue_expression_ns	hsa-mir-145	Colorectal Carcinoma	27775664	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival.
tissue_expression_ns	hsa-mir-152	Colorectal Carcinoma	27784461	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Expression of microRNA-152 in colorectal cancer and its relationship with prognosis.
tissue_expression_ns	hsa-mir-155	Colorectal Carcinoma	25773836	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.
tissue_expression_ns	hsa-mir-17	Colorectal Carcinoma	26462034	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation.
tissue_expression_ns	hsa-mir-17	Colorectal Carcinoma	23568010	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		our results are contradictory to previous studies performed on the CRC patients from Chinese population, providing an evidence against usage of serum miR-17-3p, miR-29a, miR-92a and miR-135b as new biomarkers for early detection of CRC
tissue_expression_ns	hsa-mir-182	Colorectal Carcinoma	25773836	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.
tissue_expression_ns	hsa-mir-183	Colorectal Carcinoma	26462034	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation.
tissue_expression_ns	hsa-mir-183	Colorectal Carcinoma	28289479	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Colorectal adenoma and carcinoma specific miRNA profiles in biopsy and their expression in plasma specimens.
tissue_expression_ns	hsa-mir-18a	Colorectal Carcinoma	23690963	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples.
tissue_expression_ns	hsa-mir-18a	Colorectal Carcinoma	27672263	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MicroRNA biomarkers predicting risk, initiation and progression of colorectal cancer.
tissue_expression_ns	hsa-mir-19	Colorectal Carcinoma	27775664	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival.
tissue_expression_ns	hsa-mir-192	Colorectal Carcinoma	27747302	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		high miR-192 and miR-194 correlate with better overall survival in Stage II patients, but worse survival in more advanced Stage III/IV patients
tissue_expression_ns	hsa-mir-192	Colorectal Carcinoma	27775664	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival.
tissue_expression_ns	hsa-mir-194	Colorectal Carcinoma	27747302	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		high miR-192 and miR-194 correlate with better overall survival in Stage II patients, but worse survival in more advanced Stage III/IV patients
tissue_expression_ns	hsa-mir-194	Colorectal Carcinoma	27775664	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival.
tissue_expression_ns	hsa-mir-195	Colorectal Carcinoma	25027346	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The 15 differentially expressed miRNAs, especially hsa-miR-195 and hsa-miR-20a may be used as potential biomarkers for early detection and screening of colorectal cancer.
tissue_expression_ns	hsa-mir-195	Colorectal Carcinoma	26462034	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation.
tissue_expression_ns	hsa-mir-199	Colorectal Carcinoma	27775664	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival.
tissue_expression_ns	hsa-mir-200	Colorectal Carcinoma	27157610	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The miR-200 family presented as the most powerful determinant of CMS4-specific gene expression, tuning the majority of genes differentially expressed in the poor prognosis subtype,
tissue_expression_ns	hsa-mir-200a	Colorectal Carcinoma	24510588	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-200a, miR-200c, miR-141, and miR-429 expression levels may identify CRC patients, including those with stage II disease, who are most likely to benefit from adjuvant chemotherapy.
tissue_expression_ns	hsa-mir-200a	Colorectal Carcinoma	25773836	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.
tissue_expression_ns	hsa-mir-200c	Colorectal Carcinoma	24510588	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-200a, miR-200c, miR-141, and miR-429 expression levels may identify CRC patients, including those with stage II disease, who are most likely to benefit from adjuvant chemotherapy.
tissue_expression_ns	hsa-mir-200c	Colorectal Carcinoma	25773836	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.
tissue_expression_ns	hsa-mir-200C	Colorectal Carcinoma	26335822	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The analysis of microRNAs miR-200C and miR-145 expression in colorectal cancer of different molecular subtypes.
tissue_expression_ns	hsa-mir-200c	Colorectal Carcinoma	27565378	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Investigating intra-tumor heterogeneity and expression gradients of miR-21, miR-92a and miR-200c and their potential of predicting lymph node metastases in early colorectal cancer.
tissue_expression_ns	hsa-mir-204	Colorectal Carcinoma	25209181	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-204-5p expression in colorectal cancer: an autophagy-associated gene.
tissue_expression_ns	hsa-mir-205	Colorectal Carcinoma	24935592	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Diagnostic and prognostic value of miR-205 in colorectal cancer.
tissue_expression_ns	hsa-mir-20a	Colorectal Carcinoma	25027346	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The 15 differentially expressed miRNAs, especially hsa-miR-195 and hsa-miR-20a may be used as potential biomarkers for early detection and screening of colorectal cancer.
tissue_expression_ns	hsa-mir-20a	Colorectal Carcinoma	26462034	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation.
tissue_expression_ns	hsa-mir-20a	Colorectal Carcinoma	23690963	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples.
tissue_expression_ns	hsa-mir-20a	Colorectal Carcinoma	27916938	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells.
tissue_expression_ns	hsa-mir-21	Colorectal Carcinoma	25292032	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Our findings suggest that miR-21 has a potential diagnostic value for CRC with a moderate level of overall diagnostic accuracy. Hence, it could be  used as auxiliary means for the initial screening of CRC and avoid unnecessary colonoscopy, which is an invasive and expensive procedure.
tissue_expression_ns	hsa-mir-21	Colorectal Carcinoma	25421755	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-21 expression may be a valuable biomarker for prediction of poor prognosis in CRC patients with Dukes' stage B, C and D.
tissue_expression_ns	hsa-mir-21	Colorectal Carcinoma	26462034	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation.
tissue_expression_ns	hsa-mir-21	Colorectal Carcinoma	24078989	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiRNAs might soon represent novel prognostic and diagnostic tools in patients at high risk of CRC or being diagnosed with CRC.
tissue_expression_ns	hsa-mir-21	Colorectal Carcinoma	23690963	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples.
tissue_expression_ns	hsa-mir-21	Colorectal Carcinoma	27565378	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Investigating intra-tumor heterogeneity and expression gradients of miR-21, miR-92a and miR-200c and their potential of predicting lymph node metastases in early colorectal cancer.
tissue_expression_ns	hsa-mir-21	Colorectal Carcinoma	27672263	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MicroRNA biomarkers predicting risk, initiation and progression of colorectal cancer.
tissue_expression_ns	hsa-mir-21	Colorectal Carcinoma	27775664	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival.
tissue_expression_ns	hsa-mir-21	Colorectal Carcinoma	28207045	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance.
tissue_expression_ns	hsa-mir-210	Colorectal Carcinoma	28207045	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance.
tissue_expression_ns	hsa-mir-215	Colorectal Carcinoma	27775664	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival.
tissue_expression_ns	hsa-mir-224	Colorectal Carcinoma	23932154	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.
tissue_expression_ns	hsa-mir-26a	Colorectal Carcinoma	25611389	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer.
tissue_expression_ns	hsa-mir-26b	Colorectal Carcinoma	24078989	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiRNAs might soon represent novel prognostic and diagnostic tools in patients at high risk of CRC or being diagnosed with CRC.
tissue_expression_ns	hsa-mir-27a	Colorectal Carcinoma	26913599	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Low miR-27a-expressing cells displayed more ecto-calreticulin on the cell surface and increased ATP and HMGB1 secretion than  high miR-27a-expressing ones in time-course experiments upon drug exposure.
tissue_expression_ns	hsa-mir-29a	Colorectal Carcinoma	23568010	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		our results are contradictory to previous studies performed on the CRC patients from Chinese population, providing an evidence against usage of serum miR-17-3p, miR-29a, miR-92a and miR-135b as new biomarkers for early detection of CRC
tissue_expression_ns	hsa-mir-29a	Colorectal Carcinoma	23690963	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples.
tissue_expression_ns	hsa-mir-30d	Colorectal Carcinoma	28207045	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance.
tissue_expression_ns	hsa-mir-31	Colorectal Carcinoma	25232271	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MicroRNA-31 expression in colorectal serrated pathway progression.
tissue_expression_ns	hsa-mir-3142	Colorectal Carcinoma	27916938	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells.
tissue_expression_ns	hsa-mir-3182	Colorectal Carcinoma	27916938	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells.
tissue_expression_ns	hsa-mir-320a	Colorectal Carcinoma	23932154	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.
tissue_expression_ns	hsa-mir-328	Colorectal Carcinoma	24078989	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiRNAs might soon represent novel prognostic and diagnostic tools in patients at high risk of CRC or being diagnosed with CRC.
tissue_expression_ns	hsa-mir-345	Colorectal Carcinoma	24078989	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiRNAs might soon represent novel prognostic and diagnostic tools in patients at high risk of CRC or being diagnosed with CRC.
tissue_expression_ns	hsa-mir-362	Colorectal Carcinoma	25773836	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.
tissue_expression_ns	hsa-mir-363	Colorectal Carcinoma	24519049	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression pattern in female is different from that in male.miR-363 and miR-490-5p possess the potential in screening colorectal cancer patients from healthy people.
tissue_expression_ns	hsa-mir-375	Colorectal Carcinoma	26681654	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		While the intra-tumor variance of miR-92a, miR-375 and miR-424 is substantial, it only constitutes approximately 30% of the total variation. Functional deregulation between tumor zones might contribute to variations in measured expression levels, and thus knowledge of specific intra-tumor expression patterns is crucial in tissue sampling for research as well as in future diagnostics.
tissue_expression_ns	hsa-mir-375	Colorectal Carcinoma	28618945	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression profiling of serum miR-92a, miR-375, and miR-760 in colorectal cancer: An Egyptian study.
tissue_expression_ns	hsa-mir-378a	Colorectal Carcinoma	26462034	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation.
tissue_expression_ns	hsa-mir-424	Colorectal Carcinoma	26681654	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		While the intra-tumor variance of miR-92a, miR-375 and miR-424 is substantial, it only constitutes approximately 30% of the total variation. Functional deregulation between tumor zones might contribute to variations in measured expression levels, and thus knowledge of specific intra-tumor expression patterns is crucial in tissue sampling for research as well as in future diagnostics.
tissue_expression_ns	hsa-mir-4286	Colorectal Carcinoma	27916938	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells.
tissue_expression_ns	hsa-mir-429	Colorectal Carcinoma	27775664	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival.
tissue_expression_ns	hsa-mir-4301	Colorectal Carcinoma	27916938	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells.
tissue_expression_ns	hsa-mir-490	Colorectal Carcinoma	24519049	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression pattern in female is different from that in male.miR-363 and miR-490-5p possess the potential in screening colorectal cancer patients from healthy people.
tissue_expression_ns	hsa-mir-503	Colorectal Carcinoma	29164842	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-503 is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma andseveral others
tissue_expression_ns	hsa-mir-597	Colorectal Carcinoma	27916938	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells.
tissue_expression_ns	hsa-mir-601	Colorectal Carcinoma	27672263	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MicroRNA biomarkers predicting risk, initiation and progression of colorectal cancer.
tissue_expression_ns	hsa-mir-720	Colorectal Carcinoma	27916938	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells.
tissue_expression_ns	hsa-mir-760	Colorectal Carcinoma	27672263	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MicroRNA biomarkers predicting risk, initiation and progression of colorectal cancer.
tissue_expression_ns	hsa-mir-760	Colorectal Carcinoma	28618945	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression profiling of serum miR-92a, miR-375, and miR-760 in colorectal cancer: An Egyptian study.
tissue_expression_ns	hsa-mir-92a	Colorectal Carcinoma	24551148	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MicroRNA-92a might be a novel potential biomarker in the diagnosis of colorectal cancer, and more studies are needed to highlight the theoretical strengths.
tissue_expression_ns	hsa-mir-92a	Colorectal Carcinoma	26681654	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		While the intra-tumor variance of miR-92a, miR-375 and miR-424 is substantial, it only constitutes approximately 30% of the total variation. Functional deregulation between tumor zones might contribute to variations in measured expression levels, and thus knowledge of specific intra-tumor expression patterns is crucial in tissue sampling for research as well as in future diagnostics.
tissue_expression_ns	hsa-mir-92a	Colorectal Carcinoma	24078989	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiRNAs might soon represent novel prognostic and diagnostic tools in patients at high risk of CRC or being diagnosed with CRC.
tissue_expression_ns	hsa-mir-92a	Colorectal Carcinoma	23568010	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		our results are contradictory to previous studies performed on the CRC patients from Chinese population, providing an evidence against usage of serum miR-17-3p, miR-29a, miR-92a and miR-135b as new biomarkers for early detection of CRC
tissue_expression_ns	hsa-mir-92a	Colorectal Carcinoma	23690963	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples.
tissue_expression_ns	hsa-mir-92a	Colorectal Carcinoma	27565378	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Investigating intra-tumor heterogeneity and expression gradients of miR-21, miR-92a and miR-200c and their potential of predicting lymph node metastases in early colorectal cancer.
tissue_expression_ns	hsa-mir-92a	Colorectal Carcinoma	27672263	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MicroRNA biomarkers predicting risk, initiation and progression of colorectal cancer.
tissue_expression_ns	hsa-mir-92a	Colorectal Carcinoma	28618945	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression profiling of serum miR-92a, miR-375, and miR-760 in colorectal cancer: An Egyptian study.
tissue_expression_ns	hsa-mir-1-1	Colorectal Carcinoma	21694772	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		deregulated
tissue_expression_ns	hsa-mir-1-2	Colorectal Carcinoma	21694772	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		deregulated
tissue_expression_ns	hsa-mir-133a-1	Colorectal Carcinoma	21532750	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors.
tissue_expression_ns	hsa-mir-133a-2	Colorectal Carcinoma	21532750	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors.
tissue_expression_ns	hsa-mir-135a-1	Colorectal Carcinoma	21694772	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		deregulated
tissue_expression_ns	hsa-mir-135a-2	Colorectal Carcinoma	21694772	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		deregulated
tissue_expression_ns	hsa-mir-135b	Colorectal Carcinoma	21532750	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors.
tissue_expression_ns	hsa-mir-135b	Colorectal Carcinoma	21694772	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		deregulated
tissue_expression_ns	hsa-mir-135b	Colorectal Carcinoma	22844381	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Expression of miR-21, miR-31, miR-96 and miR-135b is correlated with the clinical parameters of colorectal cancer.
tissue_expression_ns	hsa-mir-137	Colorectal Carcinoma	21532750	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors.
tissue_expression_ns	hsa-mir-137	Colorectal Carcinoma	21694772	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		deregulated
tissue_expression_ns	hsa-mir-144	Colorectal Carcinoma	22850566	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		differentially expressed
tissue_expression_ns	hsa-mir-145	Colorectal Carcinoma	25896668	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiRNA-145 and miRNA-378* are potential biomarkers for early detection of CRC, which may help in diagnosing CRC in early period.
tissue_expression_ns	hsa-mir-147b	Colorectal Carcinoma	22850566	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		differentially expressed
tissue_expression_ns	hsa-mir-148a	Colorectal Carcinoma	22850566	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		differentially expressed
tissue_expression_ns	hsa-mir-190a	Colorectal Carcinoma	22850566	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		differentially expressed
tissue_expression_ns	hsa-mir-21	Colorectal Carcinoma	22844381	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Expression of miR-21, miR-31, miR-96 and miR-135b is correlated with the clinical parameters of colorectal cancer.
tissue_expression_ns	hsa-mir-2110	Colorectal Carcinoma	22850566	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		differentially expressed
tissue_expression_ns	hsa-mir-215	Colorectal Carcinoma	21532750	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors.
tissue_expression_ns	hsa-mir-218-1	Colorectal Carcinoma	21532750	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors.
tissue_expression_ns	hsa-mir-218-2	Colorectal Carcinoma	21532750	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors.
tissue_expression_ns	hsa-mir-26a-1	Colorectal Carcinoma	22850566	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		differentially expressed
tissue_expression_ns	hsa-mir-26a-2	Colorectal Carcinoma	22850566	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		differentially expressed
tissue_expression_ns	hsa-mir-26b	Colorectal Carcinoma	22850566	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		differentially expressed
tissue_expression_ns	hsa-mir-31	Colorectal Carcinoma	21532750	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors.
tissue_expression_ns	hsa-mir-31	Colorectal Carcinoma	21694772	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		deregulated
tissue_expression_ns	hsa-mir-31	Colorectal Carcinoma	22844381	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Expression of miR-21, miR-31, miR-96 and miR-135b is correlated with the clinical parameters of colorectal cancer.
tissue_expression_ns	hsa-mir-338	Colorectal Carcinoma	24824250	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Relationship between miRNA-338-3p expression and progression and prognosis of human colorectal carcinoma.
tissue_expression_ns	hsa-mir-338	Colorectal Carcinoma	22850566	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-338-3p: differentially expressed
tissue_expression_ns	hsa-mir-375	Colorectal Carcinoma	22850566	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		differentially expressed
tissue_expression_ns	hsa-mir-378	Colorectal Carcinoma	25896668	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiRNA-145 and miRNA-378* are potential biomarkers for early detection of CRC, which may help in diagnosing CRC in early period.
tissue_expression_ns	hsa-mir-483	Colorectal Carcinoma	22850566	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-483-5p: differentially expressed
tissue_expression_ns	hsa-mir-492	Colorectal Carcinoma	22850566	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		differentially expressed
tissue_expression_ns	hsa-mir-542	Colorectal Carcinoma	22850566	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-542-5p: differentially expressed
tissue_expression_ns	hsa-mir-584	Colorectal Carcinoma	22850566	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		differentially expressed
tissue_expression_ns	hsa-mir-652	Colorectal Carcinoma	22850566	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		differentially expressed
tissue_expression_ns	hsa-mir-708	Colorectal Carcinoma	21532750	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors.
tissue_expression_ns	hsa-mir-9-1	Colorectal Carcinoma	21694772	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		deregulated
tissue_expression_ns	hsa-mir-9-2	Colorectal Carcinoma	21694772	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		deregulated
tissue_expression_ns	hsa-mir-9-3	Colorectal Carcinoma	21694772	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		deregulated
tissue_expression_ns	hsa-mir-96	Colorectal Carcinoma	22844381	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Expression of miR-21, miR-31, miR-96 and miR-135b is correlated with the clinical parameters of colorectal cancer.
tissue_expression_ns	hsa-mir-99a	Colorectal Carcinoma	21694772	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		deregulated
tissue_expression_ns	hsa-mir-126	Coronary Artery Disease	22925274	cardiovascular system disease	DOID:3393	I20-I25	D003324	608320		MiR-126 was not significantly down-regulated or up-regulated in CAD patients. Interestingly, the level of miR-126 was significantly decreased in patients with CAD and high low-density lipoprotein (LDL) cholesterol level. In contrast, the level of miR-126 was significantly increased when LDL cholesterol was high in patients who had risk factors for CAD but did not have angiographically significant CAD.
tissue_expression_ns	hsa-let-7b	Crohn Disease	27556489	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease.
tissue_expression_ns	hsa-mir-124	Crohn Disease	24910152	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	Both inflamed and non-inflamed terminal ileal mucosa in adult patients with active CD have their distinct miRNA expression patterns compared with healthy controls. Dysregulated miRNAs may be responsible for pathogenesis of CD.
tissue_expression_ns	hsa-mir-124	Crohn Disease	27556489	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease.
tissue_expression_ns	hsa-mir-192	Crohn Disease	24910152	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	Both inflamed and non-inflamed terminal ileal mucosa in adult patients with active CD have their distinct miRNA expression patterns compared with healthy controls. Dysregulated miRNAs may be responsible for pathogenesis of CD.
tissue_expression_ns	hsa-mir-192	Crohn Disease	27556489	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease.
tissue_expression_ns	hsa-mir-196b	Crohn Disease	26164662	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	We found a suite of miRNAs, including miR-31-5p, miR-215, miR-223-3p, miR-196b-5p, and miR-203 that stratify patients with CD according to disease behavior independent of the effect of inflammation.
tissue_expression_ns	hsa-mir-203	Crohn Disease	26164662	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	We found a suite of miRNAs, including miR-31-5p, miR-215, miR-223-3p, miR-196b-5p, and miR-203 that stratify patients with CD according to disease behavior independent of the effect of inflammation.
tissue_expression_ns	hsa-mir-301a	Crohn Disease	27556489	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease.
tissue_expression_ns	hsa-mir-361	Crohn Disease	24910152	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	Both inflamed and non-inflamed terminal ileal mucosa in adult patients with active CD have their distinct miRNA expression patterns compared with healthy controls. Dysregulated miRNAs may be responsible for pathogenesis of CD.
tissue_expression_ns	hsa-mir-423	Crohn Disease	27556489	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease.
tissue_expression_ns	hsa-mir-495	Crohn Disease	24910152	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	Both inflamed and non-inflamed terminal ileal mucosa in adult patients with active CD have their distinct miRNA expression patterns compared with healthy controls. Dysregulated miRNAs may be responsible for pathogenesis of CD.
tissue_expression_ns	hsa-mir-495	Crohn Disease	27556489	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease.
tissue_expression_ns	hsa-mir-99a	Crohn Disease	27556489	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease.
tissue_expression_ns	hsa-let-7a	Cutaneous Melanoma	28218741	disease of cellular proliferation	DOID:8923	C43	C562393	PS155600	HP:0012056	Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing.
tissue_expression_ns	hsa-let-7b	Cutaneous Melanoma	28218741	disease of cellular proliferation	DOID:8923	C43	C562393	PS155600	HP:0012056	Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing.
tissue_expression_ns	hsa-mir-182	Cutaneous Melanoma	28218741	disease of cellular proliferation	DOID:8923	C43	C562393	PS155600	HP:0012056	Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing.
tissue_expression_ns	hsa-mir-199b	Cutaneous Melanoma	28218741	disease of cellular proliferation	DOID:8923	C43	C562393	PS155600	HP:0012056	Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing.
tissue_expression_ns	hsa-mir-205	Cutaneous Melanoma	28218741	disease of cellular proliferation	DOID:8923	C43	C562393	PS155600	HP:0012056	Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing.
tissue_expression_ns	hsa-mir-21	Cutaneous Melanoma	28218741	disease of cellular proliferation	DOID:8923	C43	C562393	PS155600	HP:0012056	Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing.
tissue_expression_ns	hsa-mir-423	Cutaneous Melanoma	28218741	disease of cellular proliferation	DOID:8923	C43	C562393	PS155600	HP:0012056	Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing.
tissue_expression_ns	hsa-mir-424	Cutaneous Melanoma	28218741	disease of cellular proliferation	DOID:8923	C43	C562393	PS155600	HP:0012056	Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing.
tissue_expression_ns	hsa-mir-146a	Diabetes Mellitus	27743454	disease of metabolism	DOID:9351	E10-E14	D003920	222100	HP:0000819	we present an overview of the roles of miRNAs in the islet β-cell development, focusing on the application of different miRNAs in the experimental protocols
tissue_expression_ns	hsa-mir-200	Diabetes Mellitus	27743454	disease of metabolism	DOID:9351	E10-E14	D003920	222100	HP:0000819	The role of microRNAs in islet β-cell development.
tissue_expression_ns	hsa-mir-29a	Diabetes Mellitus	28003969	disease of metabolism	DOID:9351	E10-E14	D003920	222100	HP:0000819	Expression and regulation of microRNA-29a and microRNA-29c in early diabetic rat cataract formation.
tissue_expression_ns	hsa-mir-29c	Diabetes Mellitus	28003969	disease of metabolism	DOID:9351	E10-E14	D003920	222100	HP:0000819	Expression and regulation of microRNA-29a and microRNA-29c in early diabetic rat cataract formation.
tissue_expression_ns	hsa-mir-30	Diabetes Mellitus	27743454	disease of metabolism	DOID:9351	E10-E14	D003920	222100	HP:0000819	The role of microRNAs in islet β-cell development.
tissue_expression_ns	hsa-mir-342	Diabetes Mellitus	27743454	disease of metabolism	DOID:9351	E10-E14	D003920	222100	HP:0000819	The role of microRNAs in islet β-cell development.
tissue_expression_ns	hsa-mir-34a	Diabetes Mellitus	27743454	disease of metabolism	DOID:9351	E10-E14	D003920	222100	HP:0000819	The role of microRNAs in islet β-cell development.
tissue_expression_ns	hsa-mir-375	Diabetes Mellitus	27743454	disease of metabolism	DOID:9351	E10-E14	D003920	222100	HP:0000819	The role of microRNAs in islet β-cell development.
tissue_expression_ns	hsa-mir-7	Diabetes Mellitus	27743454	disease of metabolism	DOID:9351	E10-E14	D003920	222100	HP:0000819	The role of microRNAs in islet β-cell development.
tissue_expression_ns	hsa-mir-222	Diabetes Mellitus, Gestational	24601884	disease of metabolism	DOID:11714	O24.4	D016640	606176	HP:0009800	Differential expression of microRNAs in omental adipose tissue from gestational diabetes mellitus subjects reveals miR-222 as a regulator of ERα expression in estrogen-induced insulin resistance.
tissue_expression_ns	hsa-mir-103	Diabetes Mellitus, Type 2	23389544	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	The deregulation of miRNAs miR-143 (ref. 4), miR-181 (ref. 5), and miR-103 and miR-107 (ref. 6) alters hepatic insulin sensitivity.
tissue_expression_ns	hsa-mir-107	Diabetes Mellitus, Type 2	23389544	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	The deregulation of miRNAs miR-143 (ref. 4), miR-181 (ref. 5), and miR-103 and miR-107 (ref. 6) alters hepatic insulin sensitivity.
tissue_expression_ns	hsa-mir-122	Diabetes Mellitus, Type 2	27681254	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	Differentially expressed microRNAs in the corpus cavernosum from a murine model with type 2 diabetes mellitus-associated erectile dysfunction.
tissue_expression_ns	hsa-mir-124a	Diabetes Mellitus, Type 2	26897751	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	MiR-124a and miR-30d were correlated with insulin resistance and development of BC with T2DM.
tissue_expression_ns	hsa-mir-133	Diabetes Mellitus, Type 2	27681254	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	Differentially expressed microRNAs in the corpus cavernosum from a murine model with type 2 diabetes mellitus-associated erectile dysfunction.
tissue_expression_ns	hsa-mir-143	Diabetes Mellitus, Type 2	23389544	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	The deregulation of miRNAs miR-143 (ref. 4), miR-181 (ref. 5), and miR-103 and miR-107 (ref. 6) alters hepatic insulin sensitivity.
tissue_expression_ns	hsa-mir-181	Diabetes Mellitus, Type 2	23389544	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	The deregulation of miRNAs miR-143 (ref. 4), miR-181 (ref. 5), and miR-103 and miR-107 (ref. 6) alters hepatic insulin sensitivity.
tissue_expression_ns	hsa-mir-18a	Diabetes Mellitus, Type 2	27681254	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	Differentially expressed microRNAs in the corpus cavernosum from a murine model with type 2 diabetes mellitus-associated erectile dysfunction.
tissue_expression_ns	hsa-mir-206	Diabetes Mellitus, Type 2	27681254	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	Differentially expressed microRNAs in the corpus cavernosum from a murine model with type 2 diabetes mellitus-associated erectile dysfunction.
tissue_expression_ns	hsa-mir-30d	Diabetes Mellitus, Type 2	26897751	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	MiR-124a and miR-30d were correlated with insulin resistance and development of BC with T2DM.
tissue_expression_ns	hsa-mir-199a	Diabetic Cardiomyopathies	26553540				D058065			A dysregulation of 316 out of 1008 total miRNAs was observed in the diabetic hearts when compared with controls.
tissue_expression_ns	hsa-mir-203	Diabetic Foot	26722550			E10-11.621	D017719			Our results demonstrated that expression profile of miR-203 in diabetic foot had a positive correlation with the severity of diabetic foot ulcers, which indicated that miR-203 can be served as a new, accurate and validated bio-marker for evaluating the severity of diabetic foot ulcers in clinic. The significant finding of the study: Quantification of miR-203 in different degrees of diabetic foot. This study adds a new bio-marker for evaluation and management of diabetic foot.
tissue_expression_ns	hsa-mir-146a	Diabetic Peripheral Neuropathy	29398906			E11.40				miR-146a is involved in the pathogenesis of DPN, and its expression level is closely related to the inflammatory responses that aggravate sciatic nerve injuries
tissue_expression_ns	hsa-mir-150	Digeorge Syndrome	25084529	genetic disease	DOID:11198	D82.1	D004062	188400		Decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 deletion syndrome.
tissue_expression_ns	hsa-mir-185	Digeorge Syndrome	25084529	genetic disease	DOID:11198	D82.1	D004062	188400		Decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 deletion syndrome.
tissue_expression_ns	hsa-mir-194	Digeorge Syndrome	25084529	genetic disease	DOID:11198	D82.1	D004062	188400		Decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 deletion syndrome.
tissue_expression_ns	hsa-let-7c	Down Syndrome	24071828	genetic disease	DOID:14250	Q90	D004314	190685		Differentially expressed microRNAs may be involved in hemopoietic abnormalities and the immune defects of DS fetuses and newborns.
tissue_expression_ns	hsa-mir-125b-2	Down Syndrome	24071828	genetic disease	DOID:14250	Q90	D004314	190685		Differentially expressed microRNAs may be involved in hemopoietic abnormalities and the immune defects of DS fetuses and newborns.
tissue_expression_ns	hsa-mir-138	Down Syndrome	27266699	genetic disease	DOID:14250	Q90	D004314	190685		The function of hsa-miR-138-5p and its target EZH2 was involved in hippocampus in DS patients.
tissue_expression_ns	hsa-mir-146a	Down Syndrome	28720071	genetic disease	DOID:14250	Q90	D004314	190685		Developmental Expression and Dysregulation of miR-146a and miR-155 in Down's Syndrome and Mouse Models of Down's Syndrome and Alzheimer's Disease.
tissue_expression_ns	hsa-mir-155	Down Syndrome	24071828	genetic disease	DOID:14250	Q90	D004314	190685		Differentially expressed microRNAs may be involved in hemopoietic abnormalities and the immune defects of DS fetuses and newborns.
tissue_expression_ns	hsa-mir-155	Down Syndrome	28720071	genetic disease	DOID:14250	Q90	D004314	190685		Developmental Expression and Dysregulation of miR-146a and miR-155 in Down's Syndrome and Mouse Models of Down's Syndrome and Alzheimer's Disease.
tissue_expression_ns	hsa-mir-27a	Down Syndrome	27666924	genetic disease	DOID:14250	Q90	D004314	190685		Integrated microRNA and protein expression analysis reveals novel microRNA regulation of targets in fetal down syndrome.
tissue_expression_ns	hsa-mir-27b	Down Syndrome	27666924	genetic disease	DOID:14250	Q90	D004314	190685		Integrated microRNA and protein expression analysis reveals novel microRNA regulation of targets in fetal down syndrome.
tissue_expression_ns	hsa-mir-329	Down Syndrome	27666924	genetic disease	DOID:14250	Q90	D004314	190685		Integrated microRNA and protein expression analysis reveals novel microRNA regulation of targets in fetal down syndrome.
tissue_expression_ns	hsa-mir-802	Down Syndrome	24071828	genetic disease	DOID:14250	Q90	D004314	190685		Differentially expressed microRNAs may be involved in hemopoietic abnormalities and the immune defects of DS fetuses and newborns.
tissue_expression_ns	hsa-mir-99a	Down Syndrome	24071828	genetic disease	DOID:14250	Q90	D004314	190685		Differentially expressed microRNAs may be involved in hemopoietic abnormalities and the immune defects of DS fetuses and newborns.
tissue_expression_ns	hsa-mir-103	Early-Stage Gastric Carcinoma	24577775					613659		Abnormal mirna expression level in early gastric cancer tissues may be associated to the development of gastric cancer.
tissue_expression_ns	hsa-mir-141	Early-Stage Gastric Carcinoma	24577775					613659		Abnormal mirna expression level in early gastric cancer tissues may be associated to the development of gastric cancer.
tissue_expression_ns	hsa-mir-142	Early-Stage Gastric Carcinoma	24577775					613659		Abnormal mirna expression level in early gastric cancer tissues may be associated to the development of gastric cancer.
tissue_expression_ns	hsa-mir-196a	Early-Stage Gastric Carcinoma	24577775					613659		Abnormal mirna expression level in early gastric cancer tissues may be associated to the development of gastric cancer.
tissue_expression_ns	hsa-mir-25	Early-Stage Gastric Carcinoma	24577775					613659		Abnormal mirna expression level in early gastric cancer tissues may be associated to the development of gastric cancer.
tissue_expression_ns	hsa-mir-9-1	Early-Stage Gastric Carcinoma	24577775					613659		Abnormal mirna expression level in early gastric cancer tissues may be associated to the development of gastric cancer.
tissue_expression_ns	hsa-mir-16	Endometrial Neoplasms	28129244	reproductive system disease	DOID:1380	C54.1	D016889	608089		Aberrant MicroRNA Expression in Patients With Endometrial Cancer.
tissue_expression_ns	hsa-mir-1	Endometriosis	26819681	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	The expression of miR-1, miR-133a, and miR-451 were reduced significantly (p<0.0001) in the OC patients compared to its associated endometriosis.
tissue_expression_ns	hsa-mir-125a	Endometriosis	21335415	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA.
tissue_expression_ns	hsa-mir-15b	Endometriosis	21335415	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA.
tissue_expression_ns	hsa-mir-16	Endometriosis	26307093	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	Peritoneal fluid modifies the microRNA expression profile in endometrial and endometriotic cells from women with endometriosis.
tissue_expression_ns	hsa-mir-16	Endometriosis	21335415	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA.
tissue_expression_ns	hsa-mir-17	Endometriosis	21335415	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA.
tissue_expression_ns	hsa-mir-202	Endometriosis	24608518	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	Differences in miRNA levels could modulate the expression of VEGF-A and TSP-1, which may play an important role in the pathogenesis of endometriosis. The higher angiogenic and proteolytic activities observed in eutopic endometrium from patients might facilitate the implantation of endometrial cells at ectopic sites.
tissue_expression_ns	hsa-mir-20a	Endometriosis	21335415	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA.
tissue_expression_ns	hsa-mir-21	Endometriosis	21335415	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA.
tissue_expression_ns	hsa-mir-221	Endometriosis	21335415	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA.
tissue_expression_ns	hsa-mir-222	Endometriosis	21335415	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA.
tissue_expression_ns	hsa-mir-29c	Endometriosis	26307093	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	Peritoneal fluid modifies the microRNA expression profile in endometrial and endometriotic cells from women with endometriosis.
tissue_expression_ns	hsa-mir-424	Endometriosis	24608518	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	Differences in miRNA levels could modulate the expression of VEGF-A and TSP-1, which may play an important role in the pathogenesis of endometriosis. The higher angiogenic and proteolytic activities observed in eutopic endometrium from patients might facilitate the implantation of endometrial cells at ectopic sites.
tissue_expression_ns	hsa-mir-424	Endometriosis	26307093	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	Peritoneal fluid modifies the microRNA expression profile in endometrial and endometriotic cells from women with endometriosis.
tissue_expression_ns	hsa-mir-449b	Endometriosis	24608518	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	Differences in miRNA levels could modulate the expression of VEGF-A and TSP-1, which may play an important role in the pathogenesis of endometriosis. The higher angiogenic and proteolytic activities observed in eutopic endometrium from patients might facilitate the implantation of endometrial cells at ectopic sites.
tissue_expression_ns	hsa-mir-451	Endometriosis	26370665	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	Altered expression of microRNA-451 in eutopic endometrium of baboons (Papioanubis) with endometriosis.
tissue_expression_ns	hsa-mir-556	Endometriosis	24608518	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	Differences in miRNA levels could modulate the expression of VEGF-A and TSP-1, which may play an important role in the pathogenesis of endometriosis. The higher angiogenic and proteolytic activities observed in eutopic endometrium from patients might facilitate the implantation of endometrial cells at ectopic sites.
tissue_expression_ns	hsa-mir-203	Endomyocardial Fibrosis	28272698	cardiovascular system disease	DOID:12932	I42.3	D004719		HP:0006685	Effect of miR-203 expression on myocardial fibrosis.
tissue_expression_ns	hsa-mir-323a	Epilepsy	27824513	nervous system disease	DOID:1826	G40	D004827	PS601068	HP:0001250	Aberrant Expression of miR-323a-5p in Patients with Refractory Epilepsy Caused by Focal Cortical Dysplasia.
tissue_expression_ns	hsa-mir-143	Esophageal Neoplasms	23092342			C15.9	D004938	133239	HP:0100751	There are several microRNAs that have been consistently reported to be differentially expressed in esophageal squamous cell carcinoma vs. normal squamous tissue, with prognostic associations for miR-21 (invasion, positive nodes, decreased survival), miR-143 (disease recurrence, invasion depth), and miR-375 (inversely correlated with advanced stage, distant metastasis, poor overall survival, and disease-free survival).
tissue_expression_ns	hsa-mir-183	Esophageal Neoplasms	22891887			C15.9	D004938	133239	HP:0100751	The relative expressions of miR-155, miR-183, and miR-20a in esophageal tissue were found to be significantly associated with increased risk for esophageal cancer.
tissue_expression_ns	hsa-mir-20a	Esophageal Neoplasms	22891887			C15.9	D004938	133239	HP:0100751	The relative expressions of miR-155, miR-183, and miR-20a in esophageal tissue were found to be significantly associated with increased risk for esophageal cancer.
tissue_expression_ns	hsa-mir-21	Esophageal Neoplasms	23092342			C15.9	D004938	133239	HP:0100751	There are several microRNAs that have been consistently reported to be differentially expressed in esophageal squamous cell carcinoma vs. normal squamous tissue, with prognostic associations for miR-21 (invasion, positive nodes, decreased survival), miR-143 (disease recurrence, invasion depth), and miR-375 (inversely correlated with advanced stage, distant metastasis, poor overall survival, and disease-free survival).
tissue_expression_ns	hsa-mir-375	Esophageal Neoplasms	23092342			C15.9	D004938	133239	HP:0100751	There are several microRNAs that have been consistently reported to be differentially expressed in esophageal squamous cell carcinoma vs. normal squamous tissue, with prognostic associations for miR-21 (invasion, positive nodes, decreased survival), miR-143 (disease recurrence, invasion depth), and miR-375 (inversely correlated with advanced stage, distant metastasis, poor overall survival, and disease-free survival).
tissue_expression_ns	hsa-mir-106b	Ewing Sarcoma	22429812	musculoskeletal system disease	DOID:3369		D012512	612219	HP:0012254	MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression.
tissue_expression_ns	hsa-mir-145	Ewing Sarcoma	22429812	musculoskeletal system disease	DOID:3369		D012512	612219	HP:0012254	MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression.
tissue_expression_ns	hsa-mir-150	Ewing Sarcoma	22429812	musculoskeletal system disease	DOID:3369		D012512	612219	HP:0012254	MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression.
tissue_expression_ns	hsa-mir-21	Ewing Sarcoma	22429812	musculoskeletal system disease	DOID:3369		D012512	612219	HP:0012254	MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression.
tissue_expression_ns	hsa-mir-31	Ewing Sarcoma	22429812	musculoskeletal system disease	DOID:3369		D012512	612219	HP:0012254	MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression.
tissue_expression_ns	hsa-mir-371a	Ewing Sarcoma	22429812	musculoskeletal system disease	DOID:3369		D012512	612219	HP:0012254	MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression.
tissue_expression_ns	hsa-mir-557	Ewing Sarcoma	22429812	musculoskeletal system disease	DOID:3369		D012512	612219	HP:0012254	MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression.
tissue_expression_ns	hsa-mir-598	Ewing Sarcoma	22429812	musculoskeletal system disease	DOID:3369		D012512	612219	HP:0012254	MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression.
tissue_expression_ns	hsa-mir-216a	Fatty Liver [unspecific]	21764575	disease of metabolism	DOID:9452	K76.0	D005234	613282	HP:0001397	altered expression
tissue_expression_ns	hsa-mir-216b	Fatty Liver [unspecific]	21764575	disease of metabolism	DOID:9452	K76.0	D005234	613282	HP:0001397	altered expression
tissue_expression_ns	hsa-mir-302a	Fatty Liver [unspecific]	21764575	disease of metabolism	DOID:9452	K76.0	D005234	613282	HP:0001397	altered expression
tissue_expression_ns	hsa-mir-516a-1	Frontotemporal Lobar Degeneration	22032330	disease of mental health	DOID:0060672		D057174	607485		miR-516a-3p was significantly dysregulated in frontal cortex and cerebellar tissue samples of PGRN mutation carriers.
tissue_expression_ns	hsa-mir-516a-2	Frontotemporal Lobar Degeneration	22032330	disease of mental health	DOID:0060672		D057174	607485		miR-516a-3p was significantly dysregulated in frontal cortex and cerebellar tissue samples of PGRN mutation carriers.
tissue_expression_ns	hsa-mir-548b	Frontotemporal Lobar Degeneration	22032330	disease of mental health	DOID:0060672		D057174	607485		miR-548b-5p was significantly dysregulated in frontal cortex and cerebellar tissue samples of PGRN mutation carriers.
tissue_expression_ns	hsa-mir-548c	Frontotemporal Lobar Degeneration	22032330	disease of mental health	DOID:0060672		D057174	607485		miR-548c-5p was significantly dysregulated in frontal cortex and cerebellar tissue samples of PGRN mutation carriers.
tissue_expression_ns	hsa-mir-571	Frontotemporal Lobar Degeneration	22032330	disease of mental health	DOID:0060672		D057174	607485		miR-571 was significantly dysregulated in frontal cortex and cerebellar tissue samples of PGRN mutation carriers.
tissue_expression_ns	hsa-mir-922	Frontotemporal Lobar Degeneration	22032330	disease of mental health	DOID:0060672		D057174	607485		miR-922 was significantly dysregulated in frontal cortex and cerebellar tissue samples of PGRN mutation carriers.
tissue_expression_ns	hsa-mir-1244	Gastric Cardia Adenocarcinoma	26781873	disease of cellular proliferation	DOID:6271					Four miRNAs (miR-1244, miR-135b-5p, miR-3196, and miR-628-3p) were found to be associated with GCA differentiation.
tissue_expression_ns	hsa-mir-135b	Gastric Cardia Adenocarcinoma	26781873	disease of cellular proliferation	DOID:6271					Four miRNAs (miR-1244, miR-135b-5p, miR-3196, and miR-628-3p) were found to be associated with GCA differentiation.
tissue_expression_ns	hsa-mir-196a	Gastric Cardia Adenocarcinoma	26781873	disease of cellular proliferation	DOID:6271					miR-196a-5p, was found to be associated with age of GCA onset.
tissue_expression_ns	hsa-mir-3196	Gastric Cardia Adenocarcinoma	26781873	disease of cellular proliferation	DOID:6271					Four miRNAs (miR-1244, miR-135b-5p, miR-3196, and miR-628-3p) were found to be associated with GCA differentiation.
tissue_expression_ns	hsa-mir-628	Gastric Cardia Adenocarcinoma	26781873	disease of cellular proliferation	DOID:6271					Four miRNAs (miR-1244, miR-135b-5p, miR-3196, and miR-628-3p) were found to be associated with GCA differentiation.
tissue_expression_ns	hsa-let-7f-1	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-let-7f-2	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-let-7g	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-103	Gastric Neoplasms	24902858	disease of cellular proliferation	DOID:10534	C16	D013274	137215		This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer.
tissue_expression_ns	hsa-mir-103a-1	Gastric Neoplasms	20726036	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a separated node-positive from node-negative gastric cancers
tissue_expression_ns	hsa-mir-103a-2	Gastric Neoplasms	20726036	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a separated node-positive from node-negative gastric cancers
tissue_expression_ns	hsa-mir-106b	Gastric Neoplasms	20726036	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a separated node-positive from node-negative gastric cancers
tissue_expression_ns	hsa-mir-107	Gastric Neoplasms	24902858	disease of cellular proliferation	DOID:10534	C16	D013274	137215		This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer.
tissue_expression_ns	hsa-mir-1-1	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-1-2	Gastric Neoplasms	26168960	disease of cellular proliferation	DOID:10534	C16	D013274	137215		mir-17, mir-133b, mir-133a-2, and mir-1-2 appear to be a potential novel predictor of tumor stage and preoperative and intraoperative diagnosis.
tissue_expression_ns	hsa-mir-1-2	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-1207	Gastric Neoplasms	25688358	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Multivariate analysis showed that stromal reaction type, lymphovascular invasion, pathological T category and TNM stage, and expression of miR-1207-5p were independent risk factors of LNM. MiR-1207-5p could serve as a useful biomarker in the prediction of LNM in gastric cancer.
tissue_expression_ns	hsa-mir-122	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-125a	Gastric Neoplasms	21987613	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Five microRNAs (miR-125a-3p, miR-133b, miR-143, miR-195 and miR-212) were differently expressed between different metastatic groups in 30 gastric cancer biopsies (P < 0.05). Partial correlation analysis showed that hsa-mir-212 and hsa-mir-195 were correlated with the status of metastasis to LN in spite of age, gender, tumor location, tumor size, depth of invasion and cell differentiation. ROC analysis indicated that miR-212 and miR-195 have better sensitivities (84.6% and 69.2%, respectively) and specificities (both 100%) in distinguishing biopsies with metastasis to LN from biopsies without metastasis to LN.
tissue_expression_ns	hsa-mir-127	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-128-1	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-128-2	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-130a	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-132	Gastric Neoplasms	24621117	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-132 could serve as an efficient prognostic factor for gastric cancer patients.
tissue_expression_ns	hsa-mir-132	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-133a-2	Gastric Neoplasms	26168960	disease of cellular proliferation	DOID:10534	C16	D013274	137215		mir-17, mir-133b, mir-133a-2, and mir-1-2 appear to be a potential novel predictor of tumor stage and preoperative and intraoperative diagnosis.
tissue_expression_ns	hsa-mir-133b	Gastric Neoplasms	26168960	disease of cellular proliferation	DOID:10534	C16	D013274	137215		mir-17, mir-133b, mir-133a-2, and mir-1-2 appear to be a potential novel predictor of tumor stage and preoperative and intraoperative diagnosis.
tissue_expression_ns	hsa-mir-133b	Gastric Neoplasms	21987613	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Five microRNAs (miR-125a-3p, miR-133b, miR-143, miR-195 and miR-212) were differently expressed between different metastatic groups in 30 gastric cancer biopsies (P < 0.05). Partial correlation analysis showed that hsa-mir-212 and hsa-mir-195 were correlated with the status of metastasis to LN in spite of age, gender, tumor location, tumor size, depth of invasion and cell differentiation. ROC analysis indicated that miR-212 and miR-195 have better sensitivities (84.6% and 69.2%, respectively) and specificities (both 100%) in distinguishing biopsies with metastasis to LN from biopsies without metastasis to LN.
tissue_expression_ns	hsa-mir-140	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-143	Gastric Neoplasms	21874264	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-32,miR-182 and miR-143 dysregulated expression levels are related with different pathological stages of intestinal-type gastric cancers.
tissue_expression_ns	hsa-mir-143	Gastric Neoplasms	21987613	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Five microRNAs (miR-125a-3p, miR-133b, miR-143, miR-195 and miR-212) were differently expressed between different metastatic groups in 30 gastric cancer biopsies (P < 0.05). Partial correlation analysis showed that hsa-mir-212 and hsa-mir-195 were correlated with the status of metastasis to LN in spite of age, gender, tumor location, tumor size, depth of invasion and cell differentiation. ROC analysis indicated that miR-212 and miR-195 have better sensitivities (84.6% and 69.2%, respectively) and specificities (both 100%) in distinguishing biopsies with metastasis to LN from biopsies without metastasis to LN.
tissue_expression_ns	hsa-mir-145	Gastric Neoplasms	20726036	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a separated node-positive from node-negative gastric cancers
tissue_expression_ns	hsa-mir-145	Gastric Neoplasms	21874264	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-145, miR-27a, miR-494 are differently expressed between intestinal-type and diffuse-type gastric cancers.
tissue_expression_ns	hsa-mir-146a	Gastric Neoplasms	20726036	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a separated node-positive from node-negative gastric cancers
tissue_expression_ns	hsa-mir-146a	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-146b	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-148a	Gastric Neoplasms	24902858	disease of cellular proliferation	DOID:10534	C16	D013274	137215		This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer.
tissue_expression_ns	hsa-mir-148a	Gastric Neoplasms	20726036	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a separated node-positive from node-negative gastric cancers
tissue_expression_ns	hsa-mir-155	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-15b	Gastric Neoplasms	23907579	disease of cellular proliferation	DOID:10534	C16	D013274	137215		The modulation of miR-15b and miR-16 mediated the apoptosis effects of DHA in gastric cancer cells.
tissue_expression_ns	hsa-mir-16-1	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-16-2	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-17	Gastric Neoplasms	26168960	disease of cellular proliferation	DOID:10534	C16	D013274	137215		mir-17, mir-133b, mir-133a-2, and mir-1-2 appear to be a potential novel predictor of tumor stage and preoperative and intraoperative diagnosis.
tissue_expression_ns	hsa-mir-181b-1	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-181b-2	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-182	Gastric Neoplasms	21874264	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-32,miR-182 and miR-143 dysregulated expression levels are related with different pathological stages of intestinal-type gastric cancers.
tissue_expression_ns	hsa-mir-182	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-183	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-185	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-186	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-193b	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-195	Gastric Neoplasms	21987613	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Five microRNAs (miR-125a-3p, miR-133b, miR-143, miR-195 and miR-212) were differently expressed between different metastatic groups in 30 gastric cancer biopsies (P < 0.05). Partial correlation analysis showed that hsa-mir-212 and hsa-mir-195 were correlated with the status of metastasis to LN in spite of age, gender, tumor location, tumor size, depth of invasion and cell differentiation. ROC analysis indicated that miR-212 and miR-195 have better sensitivities (84.6% and 69.2%, respectively) and specificities (both 100%) in distinguishing biopsies with metastasis to LN from biopsies without metastasis to LN.
tissue_expression_ns	hsa-mir-195	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-199b	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-206	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-21	Gastric Neoplasms	24023850	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-21 has potential diagnostic value with a moderate sensitivity and specificity for GC. More prospective studies on the diagnostic value of miR-21 for GC are needed in the future.
tissue_expression_ns	hsa-mir-21	Gastric Neoplasms	24902858	disease of cellular proliferation	DOID:10534	C16	D013274	137215		This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer.
tissue_expression_ns	hsa-mir-21	Gastric Neoplasms	20726036	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a separated node-positive from node-negative gastric cancers
tissue_expression_ns	hsa-mir-21	Gastric Neoplasms	28628924	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Chrysin Alters microRNAs Expression Levels in Gastric Cancer Cells: Possible Molecular Mechanism.
tissue_expression_ns	hsa-mir-212	Gastric Neoplasms	21987613	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Five microRNAs (miR-125a-3p, miR-133b, miR-143, miR-195 and miR-212) were differently expressed between different metastatic groups in 30 gastric cancer biopsies (P < 0.05). Partial correlation analysis showed that hsa-mir-212 and hsa-mir-195 were correlated with the status of metastasis to LN in spite of age, gender, tumor location, tumor size, depth of invasion and cell differentiation. ROC analysis indicated that miR-212 and miR-195 have better sensitivities (84.6% and 69.2%, respectively) and specificities (both 100%) in distinguishing biopsies with metastasis to LN from biopsies without metastasis to LN.
tissue_expression_ns	hsa-mir-221	Gastric Neoplasms	28628924	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Chrysin Alters microRNAs Expression Levels in Gastric Cancer Cells: Possible Molecular Mechanism.
tissue_expression_ns	hsa-mir-223	Gastric Neoplasms	24902858	disease of cellular proliferation	DOID:10534	C16	D013274	137215		This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer.
tissue_expression_ns	hsa-mir-223	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-224	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-23a	Gastric Neoplasms	25674252	disease of cellular proliferation	DOID:10534	C16	D013274	137215		These results suggest that the dysregulation of miR-23a and miR-23b may be implicated in the progression of human GC. Combined expression of miR-23a and miR-23b appears to be a valuable marker for prognosis of this disease.
tissue_expression_ns	hsa-mir-23b	Gastric Neoplasms	25674252	disease of cellular proliferation	DOID:10534	C16	D013274	137215		These results suggest that the dysregulation of miR-23a and miR-23b may be implicated in the progression of human GC. Combined expression of miR-23a and miR-23b appears to be a valuable marker for prognosis of this disease.
tissue_expression_ns	hsa-mir-25	Gastric Neoplasms	24902858	disease of cellular proliferation	DOID:10534	C16	D013274	137215		This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer.
tissue_expression_ns	hsa-mir-26b	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-27a	Gastric Neoplasms	21874264	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-145, miR-27a, miR-494 are differently expressed between intestinal-type and diffuse-type gastric cancers.
tissue_expression_ns	hsa-mir-29a	Gastric Neoplasms	25889078	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Our preliminary results suggest that altered expression of miR-29a-3p is involved in gastric cancer process. The present study provides the first insight into the specific role of miR-29a-3p in gastric carcinogenesis.
tissue_expression_ns	hsa-mir-32	Gastric Neoplasms	21874264	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-32,miR-182 and miR-143 dysregulated expression levels are related with different pathological stages of intestinal-type gastric cancers.
tissue_expression_ns	hsa-mir-320a	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-328	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-340	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-342	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-34a	Gastric Neoplasms	28628924	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Chrysin Alters microRNAs Expression Levels in Gastric Cancer Cells: Possible Molecular Mechanism.
tissue_expression_ns	hsa-mir-34c	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-363	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-374a	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-374b	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-375	Gastric Neoplasms	24902858	disease of cellular proliferation	DOID:10534	C16	D013274	137215		This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer.
tissue_expression_ns	hsa-mir-421	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-487b	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-494	Gastric Neoplasms	21874264	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-145, miR-27a, miR-494 are differently expressed between intestinal-type and diffuse-type gastric cancers.
tissue_expression_ns	hsa-mir-497	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-503	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-513a-1	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-513a-2	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-513b	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-513c	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-515-1	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-515-2	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-516a-1	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-516a-2	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-516b-1	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-516b-2	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-517a	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-518f	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-519a-1	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-519a-2	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-519c	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-519e	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-520a	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-520d	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-524	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-526a-1	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-526a-2	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-574	Gastric Neoplasms	22683180	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-574-3p: Aberrant expression
tissue_expression_ns	hsa-mir-577	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-591	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-595	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-601	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-629	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-638	Gastric Neoplasms	24902858	disease of cellular proliferation	DOID:10534	C16	D013274	137215		This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer.
tissue_expression_ns	hsa-mir-640	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-658	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-661	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance
tissue_expression_ns	hsa-mir-92	Gastric Neoplasms	24902858	disease of cellular proliferation	DOID:10534	C16	D013274	137215		This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer.
tissue_expression_ns	hsa-mir-95	Gastric Neoplasms	22112324	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity
tissue_expression_ns	hsa-mir-146b	Gastrointestinal Neoplasms	23456798			D37.9	D005770			The deregulation of miR-146b-5p, miR-375, miR-148a, miR-31, and miR-451 was associated significantly with gastric adenocarcinomas.
tissue_expression_ns	hsa-mir-148a	Gastrointestinal Neoplasms	23456798			D37.9	D005770			The deregulation of miR-146b-5p, miR-375, miR-148a, miR-31, and miR-451 was associated significantly with gastric adenocarcinomas.
tissue_expression_ns	hsa-mir-200b	Gastrointestinal Neoplasms	28402940			D37.9	D005770			Prognostic role of microRNAs in human gastrointestinal cancer: A systematic review and meta-analysis.
tissue_expression_ns	hsa-mir-200c	Gastrointestinal Neoplasms	28402940			D37.9	D005770			Prognostic role of microRNAs in human gastrointestinal cancer: A systematic review and meta-analysis.
tissue_expression_ns	hsa-mir-31	Gastrointestinal Neoplasms	23456798			D37.9	D005770			The deregulation of miR-146b-5p, miR-375, miR-148a, miR-31, and miR-451 was associated significantly with gastric adenocarcinomas.
tissue_expression_ns	hsa-mir-375	Gastrointestinal Neoplasms	23456798			D37.9	D005770			The deregulation of miR-146b-5p, miR-375, miR-148a, miR-31, and miR-451 was associated significantly with gastric adenocarcinomas.
tissue_expression_ns	hsa-mir-451	Gastrointestinal Neoplasms	23456798			D37.9	D005770			The deregulation of miR-146b-5p, miR-375, miR-148a, miR-31, and miR-451 was associated significantly with gastric adenocarcinomas.
tissue_expression_ns	hsa-mir-516	Gestational Trophoblastic Disease	28381180			O01.9	D031901			Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences.
tissue_expression_ns	hsa-mir-517	Gestational Trophoblastic Disease	28381180			O01.9	D031901			Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences.
tissue_expression_ns	hsa-mir-518b	Gestational Trophoblastic Disease	28381180			O01.9	D031901			Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences.
tissue_expression_ns	hsa-mir-520a	Gestational Trophoblastic Disease	28381180			O01.9	D031901			Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences.
tissue_expression_ns	hsa-mir-520h	Gestational Trophoblastic Disease	28381180			O01.9	D031901			Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences.
tissue_expression_ns	hsa-mir-525	Gestational Trophoblastic Disease	28381180			O01.9	D031901			Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences.
tissue_expression_ns	hsa-mir-526a	Gestational Trophoblastic Disease	28381180			O01.9	D031901			Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences.
tissue_expression_ns	hsa-let-7d	Glioblastoma	24691539				D005909		HP:0100843	microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells.
tissue_expression_ns	hsa-mir-10a	Glioblastoma	24691539				D005909		HP:0100843	microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells.
tissue_expression_ns	hsa-mir-10b	Glioblastoma	24691539				D005909		HP:0100843	microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells.
tissue_expression_ns	hsa-mir-1247	Glioblastoma	27572852				D005909		HP:0100843	Several crucial genes, TFs, miRNAs and small molecules in the different GBM subgroups were identified, which may be used as potential markers
tissue_expression_ns	hsa-mir-1275	Glioblastoma	25129238				D005909		HP:0100843	We show miR-210-3p, miR-1275, miR-376c-3p, miR-23b-3p, miR-193a-3p and miR-145-5p to be up-regulated, while miR-92b-3p, miR-20a-5p, miR-10b-5p, miR-181a-2-3p and miR-185-5p are down-regulated by hypoxia.
tissue_expression_ns	hsa-mir-128-1	Glioblastoma	22844109				D005909		HP:0100843	Expression of miR-128a, -504, -124a, and -184 each negatively correlated with the expression of mesenchymal markers in GBM.
tissue_expression_ns	hsa-mir-128-2	Glioblastoma	22844109				D005909		HP:0100843	Expression of miR-128a, -504, -124a, and -184 each negatively correlated with the expression of mesenchymal markers in GBM.
tissue_expression_ns	hsa-mir-137	Glioblastoma	24691539				D005909		HP:0100843	microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells.
tissue_expression_ns	hsa-mir-145	Glioblastoma	24691539				D005909		HP:0100843	microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells.
tissue_expression_ns	hsa-mir-147b	Glioblastoma	27572852				D005909		HP:0100843	Several crucial genes, TFs, miRNAs and small molecules in the different GBM subgroups were identified, which may be used as potential markers
tissue_expression_ns	hsa-mir-153	Glioblastoma	24691539				D005909		HP:0100843	microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells.
tissue_expression_ns	hsa-mir-17	Glioblastoma	19775293				D005909		HP:0100843	Taken together, our results support an important role of altered miRNA expression in gliomas, and suggest miR-17 and miR-184 as interesting candidates contributing to glioma progression.
tissue_expression_ns	hsa-mir-181b	Glioblastoma	24691539				D005909		HP:0100843	microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells.
tissue_expression_ns	hsa-mir-184	Glioblastoma	22844109				D005909		HP:0100843	Expression of miR-128a, -504, -124a, and -184 each negatively correlated with the expression of mesenchymal markers in GBM.
tissue_expression_ns	hsa-mir-184	Glioblastoma	19775293				D005909		HP:0100843	Taken together, our results support an important role of altered miRNA expression in gliomas, and suggest miR-17 and miR-184 as interesting candidates contributing to glioma progression.
tissue_expression_ns	hsa-mir-220a	Glioblastoma	27572852				D005909		HP:0100843	miR-147b, miR-770-5p, miR-220a and miR-1247 were the particular miRNAs in subgroups 1-4
tissue_expression_ns	hsa-mir-34a	Glioblastoma	24412053				D005909		HP:0100843	Comparing miRNA expression between glioblastoma group and gliomas of grades I-III, 3 miRNAs (miR-10b, mir-34a and miR-101) showed different regulation statuses between high-grade and low-grade tumors.
tissue_expression_ns	hsa-mir-455	Glioblastoma	24691539				D005909		HP:0100843	microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells.
tissue_expression_ns	hsa-mir-503	Glioblastoma	29164842				D005909		HP:0100843	miR-503 is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma andseveral others
tissue_expression_ns	hsa-mir-504	Glioblastoma	22844109				D005909		HP:0100843	Expression of miR-128a, -504, -124a, and -184 each negatively correlated with the expression of mesenchymal markers in GBM.
tissue_expression_ns	hsa-mir-524	Glioblastoma	23924460				D005909		HP:0100843	The miRNA gene expression profiles correlate with several selected MRI features of patients with GBM. Further analysis of key imaging features of MRI with correlation with miRNA gene expression patterns may help to guide treatment decisions based on these unique correlative profiles of GBM.
tissue_expression_ns	hsa-mir-612	Glioblastoma	23924460				D005909		HP:0100843	The miRNA gene expression profiles correlate with several selected MRI features of patients with GBM. Further analysis of key imaging features of MRI with correlation with miRNA gene expression patterns may help to guide treatment decisions based on these unique correlative profiles of GBM.
tissue_expression_ns	hsa-mir-770	Glioblastoma	27572852				D005909		HP:0100843	Several crucial genes, TFs, miRNAs and small molecules in the different GBM subgroups were identified, which may be used as potential markers
tissue_expression_ns	hsa-mir-9	Glioblastoma	24691539				D005909		HP:0100843	microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells.
tissue_expression_ns	hsa-mir-105	Glioma	25415048	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miRNA expression patterns in the malignant progression of gliomas and a novel prognostic classifier, the five-miRNA signature, serve as a prognostic marker for patient risk stratification in anaplastic gliomas, Secondary and Proneural glioblastomas.
tissue_expression_ns	hsa-mir-107	Glioma	25596705	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	expression level of miR-107 may be a novel and valuable prognostic factor in glioma.
tissue_expression_ns	hsa-mir-107	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-126	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-135	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-137	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-138	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-145	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-149	Glioma	26617839	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Our study thus demonstrates that miR-149 expression in glioma tissues is critically associated with the prognosis of patients,suggesting its potential clinical significance.
tissue_expression_ns	hsa-mir-150	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-155	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-181a	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-182	Glioma	20472885	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR-182 as a prognostic marker for glioma progression and patient survival.
tissue_expression_ns	hsa-mir-184	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-186	Glioma	26231038	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	CRNDE affects the malignant biological characteristics of human glioma stem cells by negatively regulating miR-186.
tissue_expression_ns	hsa-mir-196a	Glioma	25415048	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miRNA expression patterns in the malignant progression of gliomas and a novel prognostic classifier, the five-miRNA signature, serve as a prognostic marker for patient risk stratification in anaplastic gliomas, Secondary and Proneural glioblastomas.
tissue_expression_ns	hsa-mir-205	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-21	Glioma	25452796	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Among  the six identified differentially expressed miRNAs, hsa-miR-21 and hsa-miR-612 have been previously reported to be associated with glioma.
tissue_expression_ns	hsa-mir-21	Glioma	26799295	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	4 hypoxia-mediated microRNAs (miRNA)-miR-210, miR-21, miR-10b, and miR-196b-are upregulated in glioma
tissue_expression_ns	hsa-mir-21	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-21	Glioma	28547591	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	MicroRNA-21 expression in the prognosis of low-grade gliomas: data from the cancer genome atlas (TCGA) project.
tissue_expression_ns	hsa-mir-218	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-296	Glioma	25415048	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miRNA expression patterns in the malignant progression of gliomas and a novel prognostic classifier, the five-miRNA signature, serve as a prognostic marker for patient risk stratification in anaplastic gliomas, Secondary and Proneural glioblastomas.
tissue_expression_ns	hsa-mir-34a	Glioma	25953448	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	The top 20 potential miRNAs including MIR-124A, MIR-34A and MIR-34C were screened for a constructing gene-miRNA interaction network.
tissue_expression_ns	hsa-mir-4489	Glioma	25954994	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	The dysregulated miRNAs identified in the present study contribute to the tumorigenesis and malignant progression of gliomas and may serve as useful markers for advanced glioma pathological grading and prognosis.
tissue_expression_ns	hsa-mir-584	Glioma	25415048	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miRNA expression patterns in the malignant progression of gliomas and a novel prognostic classifier, the five-miRNA signature, serve as a prognostic marker for patient risk stratification in anaplastic gliomas, Secondary and Proneural glioblastomas.
tissue_expression_ns	hsa-mir-650	Glioma	24062138	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	MicroRNA-650 expression in glioma is associated with prognosis of patients.
tissue_expression_ns	hsa-mir-7	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-767	Glioma	25415048	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miRNA expression patterns in the malignant progression of gliomas and a novel prognostic classifier, the five-miRNA signature, serve as a prognostic marker for patient risk stratification in anaplastic gliomas, Secondary and Proneural glioblastomas.
tissue_expression_ns	hsa-mir-9	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-98	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-99b	Glioma	27999452	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth
tissue_expression_ns	hsa-mir-4717	Guillain-Barre Syndrome	27836180	immune system disease	DOID:12842	G61.0	D020275	139393		MicroRNA expression profiling in Guillain-Barré syndrome.
tissue_expression_ns	hsa-mir-642b	Guillain-Barre Syndrome	27836180	immune system disease	DOID:12842	G61.0	D020275	139393		MicroRNA expression profiling in Guillain-Barré syndrome.
tissue_expression_ns	hsa-mir-125a	Head And Neck Adenoid Cystic Carcinoma	25750274							Our data showed significantly different expression patterns of mircoRNA in HNACC and HNSCC supporting the theory of tumor-specific expression and giving hints for different clinical behavior. review
tissue_expression_ns	hsa-mir-199a	Head And Neck Adenoid Cystic Carcinoma	25750274							Our data showed significantly different expression patterns of mircoRNA in HNACC and HNSCC supporting the theory of tumor-specific expression and giving hints for different clinical behavior. review
tissue_expression_ns	hsa-mir-199b	Head And Neck Adenoid Cystic Carcinoma	25750274							Our data showed significantly different expression patterns of mircoRNA in HNACC and HNSCC supporting the theory of tumor-specific expression and giving hints for different clinical behavior. review
tissue_expression_ns	hsa-mir-214	Head And Neck Adenoid Cystic Carcinoma	25750274							Our data showed significantly different expression patterns of mircoRNA in HNACC and HNSCC supporting the theory of tumor-specific expression and giving hints for different clinical behavior. review
tissue_expression_ns	hsa-mir-574	Head And Neck Adenoid Cystic Carcinoma	25750274							Our data showed significantly different expression patterns of mircoRNA in HNACC and HNSCC supporting the theory of tumor-specific expression and giving hints for different clinical behavior. review
tissue_expression_ns	hsa-mir-125a	Head And Neck Neoplasms	22690848	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Differential expression
tissue_expression_ns	hsa-mir-125b-1	Head And Neck Neoplasms	22690848	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Differential expression
tissue_expression_ns	hsa-mir-125b-2	Head And Neck Neoplasms	22690848	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Differential expression
tissue_expression_ns	hsa-mir-203	Head And Neck Neoplasms	22690848	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Differential expression
tissue_expression_ns	hsa-mir-21	Head And Neck Neoplasms	22690848	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Differential expression
tissue_expression_ns	hsa-mir-31	Head And Neck Neoplasms	22690848	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Differential expression
tissue_expression_ns	hsa-mir-355	Hearing Disorders	29781875			H91.90	D006311			Most fluids showed expression of miR-355, miR-509p, miR-515p, miR-3p, miR-873, and miR-616, but also showed significant differences between the fluid types, suggesting that miRNA profiling may be used as a diagnostic tool
tissue_expression_ns	hsa-mir-509	Hearing Disorders	29781875			H91.90	D006311			Most fluids showed expression of miR-355, miR-509p, miR-515p, miR-3p, miR-873, and miR-616, but also showed significant differences between the fluid types, suggesting that miRNA profiling may be used as a diagnostic tool
tissue_expression_ns	hsa-mir-515	Hearing Disorders	29781875			H91.90	D006311			Most fluids showed expression of miR-355, miR-509p, miR-515p, miR-3p, miR-873, and miR-616, but also showed significant differences between the fluid types, suggesting that miRNA profiling may be used as a diagnostic tool
tissue_expression_ns	hsa-mir-616	Hearing Disorders	29781875			H91.90	D006311			Most fluids showed expression of miR-355, miR-509p, miR-515p, miR-3p, miR-873, and miR-616, but also showed significant differences between the fluid types, suggesting that miRNA profiling may be used as a diagnostic tool
tissue_expression_ns	hsa-mir-873	Hearing Disorders	29781875			H91.90	D006311			Most fluids showed expression of miR-355, miR-509p, miR-515p, miR-3p, miR-873, and miR-616, but also showed significant differences between the fluid types, suggesting that miRNA profiling may be used as a diagnostic tool
tissue_expression_ns	hsa-mir-1	Heart Failure	21737570			I50	D006331		HP:0001635	In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury.
tissue_expression_ns	hsa-mir-126	Heart Failure	21737570			I50	D006331		HP:0001635	In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury.
tissue_expression_ns	hsa-mir-133	Heart Failure	21737570			I50	D006331		HP:0001635	In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury.
tissue_expression_ns	hsa-mir-195	Heart Failure	21737570			I50	D006331		HP:0001635	In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury.
tissue_expression_ns	hsa-mir-199a	Heart Failure	21737570			I50	D006331		HP:0001635	In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury.
tissue_expression_ns	hsa-mir-199b	Heart Failure	22427379			I50	D006331		HP:0001635	Six miRNAs were differently expressed when comparing D-HF (diabetic HF) and ND-HF (nondiabetic HF) patients: miR-34b, miR-34c, miR-199b, miR-210, miR-650, and miR-223.
tissue_expression_ns	hsa-mir-208	Heart Failure	21737570			I50	D006331		HP:0001635	In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury.
tissue_expression_ns	hsa-mir-208	Heart Failure	25287062			I50	D006331		HP:0001635	miR-208, which was progressively downregulated as RV failure progressed
tissue_expression_ns	hsa-mir-210	Heart Failure	22427379			I50	D006331		HP:0001635	Six miRNAs were differently expressed when comparing D-HF (diabetic HF) and ND-HF (nondiabetic HF) patients: miR-34b, miR-34c, miR-199b, miR-210, miR-650, and miR-223.
tissue_expression_ns	hsa-mir-223	Heart Failure	22427379			I50	D006331		HP:0001635	Six miRNAs were differently expressed when comparing D-HF (diabetic HF) and ND-HF (nondiabetic HF) patients: miR-34b, miR-34c, miR-199b, miR-210, miR-650, and miR-223.
tissue_expression_ns	hsa-mir-24	Heart Failure	21737570			I50	D006331		HP:0001635	In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury.
tissue_expression_ns	hsa-mir-29	Heart Failure	21737570			I50	D006331		HP:0001635	In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury.
tissue_expression_ns	hsa-mir-29b	Heart Failure	28765595			I50	D006331		HP:0001635	Integration of miRNA and mRNA expression profiles reveals microRNA-regulated networks during muscle wasting in cardiac cachexia.
tissue_expression_ns	hsa-mir-320	Heart Failure	21737570			I50	D006331		HP:0001635	In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury.
tissue_expression_ns	hsa-mir-34b	Heart Failure	22427379			I50	D006331		HP:0001635	Six miRNAs were differently expressed when comparing D-HF (diabetic HF) and ND-HF (nondiabetic HF) patients: miR-34b, miR-34c, miR-199b, miR-210, miR-650, and miR-223.
tissue_expression_ns	hsa-mir-34c	Heart Failure	22427379			I50	D006331		HP:0001635	Six miRNAs were differently expressed when comparing D-HF (diabetic HF) and ND-HF (nondiabetic HF) patients: miR-34b, miR-34c, miR-199b, miR-210, miR-650, and miR-223.
tissue_expression_ns	hsa-mir-650	Heart Failure	22427379			I50	D006331		HP:0001635	Six miRNAs were differently expressed when comparing D-HF (diabetic HF) and ND-HF (nondiabetic HF) patients: miR-34b, miR-34c, miR-199b, miR-210, miR-650, and miR-223.
tissue_expression_ns	hsa-mir-92a	Heart Failure	21737570			I50	D006331		HP:0001635	In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury.
tissue_expression_ns	hsa-mir-31	Heart Transplant Rejection	25176944			T86.31				We identified seven miRNAs that were differentially expressed between normal and rejecting heart allografts: miR-10a, miR-21, miR-31, miR-92a, miR-142-3p miR-155, and miR-451
tissue_expression_ns	hsa-mir-101	Hepatitis B Virus Infection	24971953	disease by infectious agent	DOID:2043	B16/18	D006509	610424		Expression profiling of serum microRNA-101 in HBV-associated chronic hepatitis,liver cirrhosis, and hepatocellular carcinoma.
tissue_expression_ns	hsa-mir-122	Hepatitis C Virus Infection	24696531	disease by infectious agent	DOID:1883	B19.2	D006526	609532		The study thus unveiled the role of miR-122 as a plausible diagnostic biomarker during HCV genotype-3 infection in India.
tissue_expression_ns	hsa-mir-122	Hepatitis C Virus Infection	24612050	disease by infectious agent	DOID:1883	B19.2	D006526	609532		However, a significant difference was observed in miR-122 expression between patients who showed a sustained virological response (SVR) and those who did not (P鈥?鈥?.05).
tissue_expression_ns	hsa-mir-125b	Hepatitis C Virus Infection	24637254	disease by infectious agent	DOID:1883	B19.2	D006526	609532		PBMC-miR-125b expression levels were inversely related to the achievement of an SVR in HCV-1 patients, independent of interleukin-28B genotype,and was the single predictor of SVR in non-RVR patients.
tissue_expression_ns	hsa-mir-224	Hepatitis C Virus Infection	25386083	disease by infectious agent	DOID:1883	B19.2	D006526	609532		Differences in miRNA expression were observed between CHC and steatotic CHC, CHC and steatotic liver, but not between steatotic CHC and steatotic liver of metabolic origin.
tissue_expression_ns	hsa-mir-33a	Hepatitis C Virus Infection	25386083	disease by infectious agent	DOID:1883	B19.2	D006526	609532		Differences in miRNA expression were observed between CHC and steatotic CHC, CHC and steatotic liver, but not between steatotic CHC and steatotic liver of metabolic origin.
tissue_expression_ns	hsa-mir-106b	Hepatoblastoma	26613016	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	These datasets provide a global landscape of miRNA expression for a rare childhood cancer that has not previously been well characterised. These data could serve as a resource for future studies aiming to make comparisons of HB miRNA profiles and to document aberrant miRNA expression in this type of cancer.
tissue_expression_ns	hsa-mir-122	Hepatoblastoma	24570391	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	MicroRNA expression might predict prognosis of epithelial hepatoblastoma.
tissue_expression_ns	hsa-mir-140	Hepatoblastoma	24570391	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	MicroRNA expression might predict prognosis of epithelial hepatoblastoma.
tissue_expression_ns	hsa-mir-17	Hepatoblastoma	24570391	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	MicroRNA expression might predict prognosis of epithelial hepatoblastoma.
tissue_expression_ns	hsa-mir-17	Hepatoblastoma	26613016	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	These datasets provide a global landscape of miRNA expression for a rare childhood cancer that has not previously been well characterised. These data could serve as a resource for future studies aiming to make comparisons of HB miRNA profiles and to document aberrant miRNA expression in this type of cancer.
tissue_expression_ns	hsa-mir-18a	Hepatoblastoma	24570391	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	MicroRNA expression might predict prognosis of epithelial hepatoblastoma.
tissue_expression_ns	hsa-mir-191	Hepatoblastoma	26613016	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	These datasets provide a global landscape of miRNA expression for a rare childhood cancer that has not previously been well characterised. These data could serve as a resource for future studies aiming to make comparisons of HB miRNA profiles and to document aberrant miRNA expression in this type of cancer.
tissue_expression_ns	hsa-mir-195	Hepatoblastoma	24570391	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	MicroRNA expression might predict prognosis of epithelial hepatoblastoma.
tissue_expression_ns	hsa-mir-210	Hepatoblastoma	24570391	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	MicroRNA expression might predict prognosis of epithelial hepatoblastoma.
tissue_expression_ns	hsa-mir-214	Hepatoblastoma	24570391	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	MicroRNA expression might predict prognosis of epithelial hepatoblastoma.
tissue_expression_ns	hsa-mir-221	Hepatoblastoma	24570391	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	MicroRNA expression might predict prognosis of epithelial hepatoblastoma.
tissue_expression_ns	hsa-mir-222	Hepatoblastoma	24570391	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	MicroRNA expression might predict prognosis of epithelial hepatoblastoma.
tissue_expression_ns	hsa-mir-223	Hepatoblastoma	24570391	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	MicroRNA expression might predict prognosis of epithelial hepatoblastoma.
tissue_expression_ns	hsa-mir-224	Hepatoblastoma	24570391	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	MicroRNA expression might predict prognosis of epithelial hepatoblastoma.
tissue_expression_ns	hsa-mir-34a	Hepatoblastoma	24570391	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	MicroRNA expression might predict prognosis of epithelial hepatoblastoma.
tissue_expression_ns	hsa-mir-95	Hepatoblastoma	26613016	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	These datasets provide a global landscape of miRNA expression for a rare childhood cancer that has not previously been well characterised. These data could serve as a resource for future studies aiming to make comparisons of HB miRNA profiles and to document aberrant miRNA expression in this type of cancer.
tissue_expression_ns	hsa-mir-96	Hepatoblastoma	24570391	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	MicroRNA expression might predict prognosis of epithelial hepatoblastoma.
tissue_expression_ns	hsa-mir-210	Human Immunodeficiency Virus Infection	27749601			B20	D015658	609423		MicroRNA-210, MicroRNA-331, and MicroRNA-7 Are Differentially Regulated in Treated HIV-1-Infected Individuals and Are Associated With Markers of Systemic Inflammation.
tissue_expression_ns	hsa-mir-331	Human Immunodeficiency Virus Infection	27749601			B20	D015658	609423		MicroRNA-210, MicroRNA-331, and MicroRNA-7 Are Differentially Regulated in Treated HIV-1-Infected Individuals and Are Associated With Markers of Systemic Inflammation.
tissue_expression_ns	hsa-mir-7	Human Immunodeficiency Virus Infection	27749601			B20	D015658	609423		MicroRNA-210, MicroRNA-331, and MicroRNA-7 Are Differentially Regulated in Treated HIV-1-Infected Individuals and Are Associated With Markers of Systemic Inflammation.
tissue_expression_ns	hsa-mir-150	Human Papilloma Virus Infection	28302562			B97.7	D027383			Dysregulated expression of microRNA-150 in human papillomavirus-induced lesions of K14-HPV16 transgenic mice.
tissue_expression_ns	hsa-mir-155	Human Papilloma Virus Infection	25550598			B97.7	D027383			Evaluation of miRNA expression might be helpful to distinguish different cervical lesions and might be able to help in the prediction of HPV infection outcome. epithelial cell adhesion molecule
tissue_expression_ns	hsa-mir-196a	Human Papilloma Virus Infection	25550598			B97.7	D027383			Evaluation of miRNA expression might be helpful to distinguish different cervical lesions and might be able to help in the prediction of HPV infection outcome. epithelial cell adhesion molecule
tissue_expression_ns	hsa-mir-203	Human Papilloma Virus Infection	25550598			B97.7	D027383			Evaluation of miRNA expression might be helpful to distinguish different cervical lesions and might be able to help in the prediction of HPV infection outcome. epithelial cell adhesion molecule
tissue_expression_ns	hsa-mir-27a	Human Papilloma Virus Infection	25550598			B97.7	D027383			Evaluation of miRNA expression might be helpful to distinguish different cervical lesions and might be able to help in the prediction of HPV infection outcome. epithelial cell adhesion molecule
tissue_expression_ns	hsa-mir-34a	Human Papilloma Virus Infection	25550598			B97.7	D027383			Evaluation of miRNA expression might be helpful to distinguish different cervical lesions and might be able to help in the prediction of HPV infection outcome. epithelial cell adhesion molecule
tissue_expression_ns	hsa-mir-155	Hypertension	25087597	cardiovascular system disease	DOID:10763	I10	D006973	145500	HP:0000822	In addition, exercise training in SHR increased levels of microRNA-27a (targeting ACE) and microRNA-155 (targeting AT1R) and decreased levels of microRNA-143 (targeting ACE2) in the aortas.
tissue_expression_ns	hsa-mir-200b	Hypertrophic Scar	26500110			L91.0	D017439			Aberrant miR-21 and miR-200b expression and its pro-fibrotic potential in hypertrophic scars.
tissue_expression_ns	hsa-mir-21	Hypertrophic Scar	26500110			L91.0	D017439			Aberrant miR-21 and miR-200b expression and its pro-fibrotic potential in hypertrophic scars.
tissue_expression_ns	hsa-mir-133a	Hypertrophy	25147795				D006984			Fifty-seven miRNAs were expressed differentially between transgenic and littermate controls, of which most abundant miRNAs, miR-133a and 378a, were significantly differentially expressed.
tissue_expression_ns	hsa-mir-126	Immune System Disease [unspecific]	20682703	immune system disease	DOID:2914	D89.9	D007154			Although altered expressions of miR-21 and miR-34a were manifested within cancer cells, those of miR-126 and miR-155 were predominantly confined to endothelial cells and immune cells, respectively.
tissue_expression_ns	hsa-mir-155	Immune System Disease [unspecific]	20682703	immune system disease	DOID:2914	D89.9	D007154			Although altered expressions of miR-21 and miR-34a were manifested within cancer cells, those of miR-126 and miR-155 were predominantly confined to endothelial cells and immune cells, respectively.
tissue_expression_ns	hsa-mir-31	Immune System Disease [unspecific]	23352895	immune system disease	DOID:2914	D89.9	D007154			Bantam, miR-276*, miR-10, miR-31 and miR-184 were detected as five most abundant miRNAs in both libraries and 96 miRNAs were identified that were differentially expressed after parasitization.
tissue_expression_ns	hsa-mir-21	Infection [unspecific]	28472924				D007239			Identification of differentially expressed Atlantic salmon miRNAs responding to salmonid alphavirus (SAV) infection.
tissue_expression_ns	hsa-mir-34c	Infertility	28886318	reproductive system disease	DOID:5223	N46.9/N97.9	D007246			New insights into the expression profile of MicroRNA-34c and P53 in infertile men spermatozoa and testicular tissue.
tissue_expression_ns	hsa-mir-132	Inflammation	25564423				D007249			We assessed miRNA and mRNA expression in lung infiltrating mononuclear cells following exposure to SEB and found 89 miRNA that were dysregulated (>2-fold) compared with vehicle controls.
tissue_expression_ns	hsa-mir-143	Inflammation	27776879				D007249			Expression Profiles of Inflammation-associated microRNAs in Periapical Lesions and Human Periodontal Ligament Fibroblasts Inflammation.
tissue_expression_ns	hsa-mir-146	Inflammation	18291670				D007249			Recent evidence showing altered miRNA expression in chronic inflammatory diseases (e.g. miR-203 and miR-146) suggests their involvement in immune-mediated diseases.
tissue_expression_ns	hsa-mir-146a	Inflammation	16885212				D007249			Analysis of miR-146a and miR-146b gene expression unveiled a pattern of induction in response to a variety of microbial components and proinflammatory cytokines.
tissue_expression_ns	hsa-mir-146b	Inflammation	16885212				D007249			Analysis of miR-146a and miR-146b gene expression unveiled a pattern of induction in response to a variety of microbial components and proinflammatory cytokines.
tissue_expression_ns	hsa-mir-15b	Inflammation	20564181				D007249			Of note, differentially expressed miRNAs (hsa-miR-15b and 181b) may have a potential role in regulating these processes.
tissue_expression_ns	hsa-mir-181b	Inflammation	20564181				D007249			Of note, differentially expressed miRNAs (hsa-miR-15b and 181b) may have a potential role in regulating these processes.
tissue_expression_ns	hsa-mir-223	Inflammation	27129807				D007249			miR-223 that has been reported to be abnormally expressed in several diseases like diabetes-type2, sepsis, rheumatoid arthritis, viral infections likes' human immunodeficiency virus-1 (HIV-1) and inflammatory disorders.
tissue_expression_ns	hsa-mir-31	Inflammation	26303911				D007249			We identified three miRNAs, miR-497, miR-351 and miR-31, that are candidate master regulators of genes associated with neutrophil recruitment.
tissue_expression_ns	hsa-mir-106a	Inflammatory Bowel Diseases	22899284	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	A significant difference in expressions of miR-19b, miR-106a, and miR-629 was detected between ulcerative colitis and Crohns disease groups (P<0.05).
tissue_expression_ns	hsa-mir-146a	Inflammatory Bowel Diseases	24051693	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	In summary,we demonstrate that miR-31, miR-206, miR-424, and miR-146a are novel specific biomarkers of inflammatory bowel disease.
tissue_expression_ns	hsa-mir-19b-1	Inflammatory Bowel Diseases	22899284	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	A significant difference in expressions of miR-19b, miR-106a, and miR-629 was detected between ulcerative colitis and Crohns disease groups (P<0.05).
tissue_expression_ns	hsa-mir-19b-2	Inflammatory Bowel Diseases	22899284	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	A significant difference in expressions of miR-19b, miR-106a, and miR-629 was detected between ulcerative colitis and Crohns disease groups (P<0.05).
tissue_expression_ns	hsa-mir-206	Inflammatory Bowel Diseases	24051693	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	In summary,we demonstrate that miR-31, miR-206, miR-424, and miR-146a are novel specific biomarkers of inflammatory bowel disease.
tissue_expression_ns	hsa-mir-21	Inflammatory Bowel Diseases	25222661	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	MiRNAs are differentially expressed in both human IBD and murine colitis, with overlap of several IBD-associated miRNAs. The demonstration that miR-21-/- deletion exacerbated CD4+ T-cell-mediated models of colitis provide further evidence that miRNAs play significant roles in the pathogenesis of IBD.
tissue_expression_ns	hsa-mir-31	Inflammatory Bowel Diseases	24051693	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	In summary,we demonstrate that miR-31, miR-206, miR-424, and miR-146a are novel specific biomarkers of inflammatory bowel disease.
tissue_expression_ns	hsa-mir-31	Inflammatory Bowel Diseases	20848542	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	Dynamic changes in the expression of MicroRNA-31 during inflammatory bowel disease-associated neoplastic transformation.
tissue_expression_ns	hsa-mir-424	Inflammatory Bowel Diseases	24051693	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	In summary,we demonstrate that miR-31, miR-206, miR-424, and miR-146a are novel specific biomarkers of inflammatory bowel disease.
tissue_expression_ns	hsa-mir-629	Inflammatory Bowel Diseases	22899284	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	A significant difference in expressions of miR-19b, miR-106a, and miR-629 was detected between ulcerative colitis and Crohns disease groups (P<0.05).
tissue_expression_ns	hsa-mir-99b	Inflammatory Bowel Diseases	26466382	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	These results suggest that the proposed miRNA signature is of relevance for the etiology of IBD. Its diagnostic value, however, should be further evaluated in large, independent, clinically well characterized cohorts.
tissue_expression_ns	hsa-mir-143	Intracranial Aneurysm	25300531	cardiovascular system disease	DOID:10941	I67.1	D002532	105800		As compared to normal arteries, we identified 157 microRNAs that were differentially expressed in the aneurysmal tissue (P鈥?鈥?.05 and fold change鈥夆墺鈥?), including 72 upregulated and 85 downregulated.
tissue_expression_ns	hsa-mir-103	Intrahepatic Cholangiocarcinoma	25880914	disease of cellular proliferation	DOID:4928	C22.1	D018281	615619		In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression.
tissue_expression_ns	hsa-mir-146a	Intrahepatic Cholangiocarcinoma	25880914	disease of cellular proliferation	DOID:4928	C22.1	D018281	615619		In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression.
tissue_expression_ns	hsa-mir-216a	Intrahepatic Cholangiocarcinoma	25880914	disease of cellular proliferation	DOID:4928	C22.1	D018281	615619		In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression.
tissue_expression_ns	hsa-mir-216b	Intrahepatic Cholangiocarcinoma	25880914	disease of cellular proliferation	DOID:4928	C22.1	D018281	615619		In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression.
tissue_expression_ns	hsa-mir-217	Intrahepatic Cholangiocarcinoma	25880914	disease of cellular proliferation	DOID:4928	C22.1	D018281	615619		In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression.
tissue_expression_ns	hsa-mir-338	Intrahepatic Cholangiocarcinoma	25880914	disease of cellular proliferation	DOID:4928	C22.1	D018281	615619		In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression.
tissue_expression_ns	hsa-mir-513	Intrahepatic Cholangiocarcinoma	25880914	disease of cellular proliferation	DOID:4928	C22.1	D018281	615619		In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression.
tissue_expression_ns	hsa-mir-652	Intrahepatic Cholangiocarcinoma	25880914	disease of cellular proliferation	DOID:4928	C22.1	D018281	615619		In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression.
tissue_expression_ns	hsa-mir-675	Intrahepatic Cholangiocarcinoma	25880914	disease of cellular proliferation	DOID:4928	C22.1	D018281	615619		In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression.
tissue_expression_ns	hsa-mir-126	Ischemia	26672806	cardiovascular system disease	DOID:326		D007511	601367		ghrelin treatment activated proangiogenic (miR-126  and miR-132) and antifibrotic (miR-30a) microRNAs (miRs)
tissue_expression_ns	hsa-mir-206	Ischemia	26672806	cardiovascular system disease	DOID:326		D007511	601367		ghrelin treatment activated proangiogenic (miR-126  and miR-132) and antifibrotic (miR-30a) microRNAs (miRs)
tissue_expression_ns	hsa-mir-21	Ischemia	21373187	cardiovascular system disease	DOID:326		D007511	601367		deregulated
tissue_expression_ns	hsa-mir-210	Ischemia	23931770	cardiovascular system disease	DOID:326		D007511	601367		The physiopathological significance of miR-210 is context dependent. In the ischemic skeletal muscle it seems to be cytoprotective, regulating oxidative metabolism and oxidative stress.
tissue_expression_ns	hsa-mir-29b-1	Ischemia	21373187	cardiovascular system disease	DOID:326		D007511	601367		deregulated
tissue_expression_ns	hsa-mir-29b-2	Ischemia	21373187	cardiovascular system disease	DOID:326		D007511	601367		deregulated
tissue_expression_ns	hsa-mir-30b	Ischemia	21373187	cardiovascular system disease	DOID:326		D007511	601367		deregulated
tissue_expression_ns	hsa-mir-92a	Ischemia	26672806	cardiovascular system disease	DOID:326		D007511	601367		Further, ghrelin treatment activated proangiogenic (miR-126  and miR-132) and antifibrotic (miR-30a) microRNAs (miRs) while inhibiting antiangiogenic (miR-92a and miR-206) miRs.
tissue_expression_ns	hsa-mir-1	Ischemia-Reperfusion Injury	29642230				D015427			Most commonly reported miRNAs with differential expression between preconditioned and control groups include miR-1, miR-21 and miR-144
tissue_expression_ns	hsa-mir-144	Ischemia-Reperfusion Injury	29642230				D015427			Most commonly reported miRNAs with differential expression between preconditioned and control groups include miR-1, miR-21 and miR-144
tissue_expression_ns	hsa-mir-146a	Ischemia-Reperfusion Injury	20651252				D015427			miR-146a:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI
tissue_expression_ns	hsa-mir-187	Ischemia-Reperfusion Injury	20651252				D015427			miR-187:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI
tissue_expression_ns	hsa-mir-192	Ischemia-Reperfusion Injury	20651252				D015427			miR-192:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI
tissue_expression_ns	hsa-mir-194-1	Ischemia-Reperfusion Injury	20651252				D015427			miR-194:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI
tissue_expression_ns	hsa-mir-194-2	Ischemia-Reperfusion Injury	20651252				D015427			miR-194:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI
tissue_expression_ns	hsa-mir-199a-1	Ischemia-Reperfusion Injury	20651252				D015427			miR-199a-3p:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI
tissue_expression_ns	hsa-mir-199a-2	Ischemia-Reperfusion Injury	20651252				D015427			miR-199a-3p:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI
tissue_expression_ns	hsa-mir-20a	Ischemia-Reperfusion Injury	20651252				D015427			miR-20a:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI
tissue_expression_ns	hsa-mir-21	Ischemia-Reperfusion Injury	20651252				D015427			miR-21:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI
tissue_expression_ns	hsa-mir-21	Ischemia-Reperfusion Injury	29642230				D015427			Most commonly reported miRNAs with differential expression between preconditioned and control groups include miR-1, miR-21 and miR-144
tissue_expression_ns	hsa-mir-214	Ischemia-Reperfusion Injury	20651252				D015427			miR-214:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI
tissue_expression_ns	hsa-mir-210	Ischemic Diseases [unspecific]	27750254				D007511	601367		Temporal Profile of Circulating microRNAs after Global Hypoxia-Ischemia in Newborn Piglets.
tissue_expression_ns	hsa-mir-24	Kaposi Sarcoma	19381257	disease of cellular proliferation	DOID:8632	C46	D012514			Mir-140 and Kaposi sarcoma-associated herpesvirus viral miRNAs increased linearly with the degree of transformation. Mir-24 emerged as a biomarker specific for KS.
tissue_expression_ns	hsa-mir-199a	Keloid	24782087			L91.0	D007627	148100	HP:0010562	Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblasts.
tissue_expression_ns	hsa-let-7d	Kidney Diseases [unspecific]	28414804			N18.9	D007674			Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity.
tissue_expression_ns	hsa-mir-130	Kidney Diseases [unspecific]	28414804			N18.9	D007674			Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity.
tissue_expression_ns	hsa-mir-186	Kidney Diseases [unspecific]	28414804			N18.9	D007674			Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity.
tissue_expression_ns	hsa-mir-192	Kidney Diseases [unspecific]	28414804			N18.9	D007674			Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity.
tissue_expression_ns	hsa-mir-200	Kidney Diseases [unspecific]	28414804			N18.9	D007674			Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity.
tissue_expression_ns	hsa-mir-21	Kidney Diseases [unspecific]	28414804			N18.9	D007674			Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity.
tissue_expression_ns	hsa-mir-29	Kidney Diseases [unspecific]	28414804			N18.9	D007674			Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity.
tissue_expression_ns	hsa-mir-30	Kidney Diseases [unspecific]	28414804			N18.9	D007674			Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity.
tissue_expression_ns	hsa-mir-709	Kidney Diseases [unspecific]	28414804			N18.9	D007674			Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity.
tissue_expression_ns	hsa-mir-1264	Laryngeal Neoplasms	23826416			C32.3	D007822			Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line.
tissue_expression_ns	hsa-mir-1265	Laryngeal Neoplasms	23826416			C32.3	D007822			Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line.
tissue_expression_ns	hsa-mir-1277	Laryngeal Neoplasms	23826416			C32.3	D007822			Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line.
tissue_expression_ns	hsa-mir-1291	Laryngeal Neoplasms	23826416			C32.3	D007822			Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line.
tissue_expression_ns	hsa-mir-130a	Laryngeal Neoplasms	23826416			C32.3	D007822			Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line.
tissue_expression_ns	hsa-mir-155	Laryngeal Neoplasms	27292022			C32.3	D007822			miR-21, miR-155, miR-192, and miR-375 Deregulations Related to NF-kappaB Activation in Gastroduodenal Fluid-Induced Early Preneoplastic Lesions of Laryngeal Mucosa In Vivo.
tissue_expression_ns	hsa-mir-192	Laryngeal Neoplasms	27292022			C32.3	D007822			miR-21, miR-155, miR-192, and miR-375 Deregulations Related to NF-kappaB Activation in Gastroduodenal Fluid-Induced Early Preneoplastic Lesions of Laryngeal Mucosa In Vivo.
tissue_expression_ns	hsa-mir-195	Laryngeal Neoplasms	23826416			C32.3	D007822			Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line.
tissue_expression_ns	hsa-mir-21	Laryngeal Neoplasms	23259291			C32.3	D007822			Expression of mir-21 and mir-375 in laryngeal squamous cell carcinoma
tissue_expression_ns	hsa-mir-21	Laryngeal Neoplasms	27292022			C32.3	D007822			miR-21, miR-155, miR-192, and miR-375 Deregulations Related to NF-kappaB Activation in Gastroduodenal Fluid-Induced Early Preneoplastic Lesions of Laryngeal Mucosa In Vivo.
tissue_expression_ns	hsa-mir-214	Laryngeal Neoplasms	23826416			C32.3	D007822			Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line.
tissue_expression_ns	hsa-mir-27b	Laryngeal Neoplasms	23826416			C32.3	D007822			Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line.
tissue_expression_ns	hsa-mir-375	Laryngeal Neoplasms	23259291			C32.3	D007822			Expression of mir-21 and mir-375 in laryngeal squamous cell carcinoma
tissue_expression_ns	hsa-mir-375	Laryngeal Neoplasms	27292022			C32.3	D007822			miR-21, miR-155, miR-192, and miR-375 Deregulations Related to NF-kappaB Activation in Gastroduodenal Fluid-Induced Early Preneoplastic Lesions of Laryngeal Mucosa In Vivo.
tissue_expression_ns	hsa-mir-1287	Laryngeal Neoplasms	24238754			C32.3	D007822			Identification of predictive biomarkers for early diagnosis of larynx carcinoma based on microRNA expression data.
tissue_expression_ns	hsa-mir-657	Laryngeal Neoplasms	24238754			C32.3	D007822			Identification of predictive biomarkers for early diagnosis of larynx carcinoma based on microRNA expression data.
tissue_expression_ns	hsa-mir-137	Leiomyoma	22446413	disease of cellular proliferation	DOID:127	D25	D007889	150699		deregulated
tissue_expression_ns	hsa-mir-217	Leiomyoma	22446413	disease of cellular proliferation	DOID:127	D25	D007889	150699		deregulated
tissue_expression_ns	hsa-mir-363	Leiomyoma	22446413	disease of cellular proliferation	DOID:127	D25	D007889	150699		deregulated
tissue_expression_ns	hsa-mir-4792	Leiomyoma	22446413	disease of cellular proliferation	DOID:127	D25	D007889	150699		deregulated
tissue_expression_ns	hsa-mir-490	Leiomyoma	22446413	disease of cellular proliferation	DOID:127	D25	D007889	150699		deregulated
tissue_expression_ns	hsa-mir-142	Leukemia	19246560			C95	D007938	613065	HP:0001909	Here, we report aberrant expression of hematopoietic-specific miR-223, miR-181a, miR-150, miR-142.3p, and miR-155 in HTLV-I-infected cells in vitro and uncultured ex vivo ATL cells.
tissue_expression_ns	hsa-mir-150	Leukemia	19246560			C95	D007938	613065	HP:0001909	Here, we report aberrant expression of hematopoietic-specific miR-223, miR-181a, miR-150, miR-142.3p, and miR-155 in HTLV-I-infected cells in vitro and uncultured ex vivo ATL cells.
tissue_expression_ns	hsa-mir-155	Leukemia	19246560			C95	D007938	613065	HP:0001909	Here, we report aberrant expression of hematopoietic-specific miR-223, miR-181a, miR-150, miR-142.3p, and miR-155 in HTLV-I-infected cells in vitro and uncultured ex vivo ATL cells.
tissue_expression_ns	hsa-mir-17	Leukemia	24479800			C95	D007938	613065	HP:0001909	Aberrant expression of oncogenic miRNAs, including miR-155, miR-17-92, miR-21, miR-125b, miR-93, miR-143-p3, miR-196b, and miR-223 promotes leukemogenesis through increasing the  leukemic stem/progenitor cell population, promoting cell proliferation, blocking  cell differentiation, and diminishing cell apoptosis.
tissue_expression_ns	hsa-mir-17	Leukemia	28105201			C95	D007938	613065	HP:0001909	Comparison of microRNA expression profiles in K562-cells-derived microvesicles and parental cells, and analysis of their roles in leukemia.
tissue_expression_ns	hsa-mir-181a	Leukemia	19246560			C95	D007938	613065	HP:0001909	Here, we report aberrant expression of hematopoietic-specific miR-223, miR-181a, miR-150, miR-142.3p, and miR-155 in HTLV-I-infected cells in vitro and uncultured ex vivo ATL cells.
tissue_expression_ns	hsa-mir-21	Leukemia	21882851			C95	D007938	613065	HP:0001909	Many aberrantly expressed miRNAs were related to various cancers (e.g., miR-125b, hepatocellular carcinoma; miR-21, leukemia; miR-16, chronic lymphocytic leukemia;miR-192, pituitary adenomas; miR-199a-3p, ovarian cancer; miR-34a, pancreatic cancer).
tissue_expression_ns	hsa-mir-223	Leukemia	19246560			C95	D007938	613065	HP:0001909	Here, we report aberrant expression of hematopoietic-specific miR-223, miR-181a, miR-150, miR-142.3p, and miR-155 in HTLV-I-infected cells in vitro and uncultured ex vivo ATL cells.
tissue_expression_ns	hsa-mir-34a	Leukemia	29780367			C95	D007938	613065	HP:0001909	Expression of miR-34a in T-Cells Infected by Human T-Lymphotropic Virus 1.
tissue_expression_ns	hsa-mir-15a	Leukemia, Lymphocytic, Chronic, B-Cell	17941951	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	altered expression
tissue_expression_ns	hsa-mir-16-1	Leukemia, Lymphocytic, Chronic, B-Cell	17941951	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	altered expression
tissue_expression_ns	hsa-mir-16	Leukemia, Lymphocytic, Chronic, B-Cell	21882851	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	Many aberrantly expressed miRNAs were related to various cancers (e.g., miR-125b, hepatocellular carcinoma; miR-21, leukemia; miR-16, chronic lymphocytic leukemia;miR-192, pituitary adenomas; miR-199a-3p, ovarian cancer; miR-34a, pancreatic cancer).
tissue_expression_ns	hsa-mir-221	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	20299489			C92.1	D015464			Among them, the expression of miR-34a, miR-221, and miR-222 was induced in the early stages and maintained throughout the late stages of differentiation.
tissue_expression_ns	hsa-mir-222	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	20299489			C92.1	D015464			Among them, the expression of miR-34a, miR-221, and miR-222 was induced in the early stages and maintained throughout the late stages of differentiation.
tissue_expression_ns	hsa-mir-34a	Leukemia, Myelogenous, Chronic, BCR-ABL Positive	20299489			C92.1	D015464			Among them, the expression of miR-34a, miR-221, and miR-222 was induced in the early stages and maintained throughout the late stages of differentiation.
tissue_expression_ns	hsa-mir-182	Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic	22582938	disease of cellular proliferation	DOID:5599	C83.5	D054218			Aberrant microRNA-182 expression is associated with glucocorticoid resistance in lymphoblastic malignancies.
tissue_expression_ns	hsa-mir-145	Liposarcoma	24375455	disease of cellular proliferation	DOID:3382	C49.9	D008080	613488	HP:0012034	MicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors.
tissue_expression_ns	hsa-mir-155	Liposarcoma	25888631	disease of cellular proliferation	DOID:3382	C49.9	D008080	613488	HP:0012034	Deregulation of dicer and mir-155 expression in liposarcoma.
tissue_expression_ns	hsa-mir-451	Liposarcoma	24375455	disease of cellular proliferation	DOID:3382	C49.9	D008080	613488	HP:0012034	MicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors.
tissue_expression_ns	hsa-mir-122	Liver Cirrhosis	27879410	endocrine system disease	DOID:5082	K74	D008103	215600	HP:0001394	We also detected expression of hsa-miR-122 in primitive ductular reactions expected for hepatocytic differentiation and hsa-miR-23b cluster expression that drives liver cell fate decisions in cells undergoing lineage commitment
tissue_expression_ns	hsa-mir-23b	Liver Cirrhosis	27879410	endocrine system disease	DOID:5082	K74	D008103	215600	HP:0001394	We also detected expression of hsa-miR-122 in primitive ductular reactions expected for hepatocytic differentiation and hsa-miR-23b cluster expression that drives liver cell fate decisions in cells undergoing lineage commitment
tissue_expression_ns	hsa-mir-378	Liver Diseases [unspecific]	23818290			K76.9	D008107			Dietary fisetin protects against hepatosteatosis in association with modulation of lipid metabolism genes and miR-378 in mice
tissue_expression_ns	hsa-mir-155	Liver Injury	27673475			S36.11	D056486			Fine-tuning the expression of microRNA-155 controls acetaminophen-induced liver inflammation.
tissue_expression_ns	hsa-mir-141	Liver Neoplasms	19167416	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis
tissue_expression_ns	hsa-mir-146a	Liver Neoplasms	24431000	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	Aberrant miRNA expression response to UV irradiation in human liver cancer cells.
tissue_expression_ns	hsa-mir-18	Liver Neoplasms	19167416	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis
tissue_expression_ns	hsa-mir-182	Liver Neoplasms	19167416	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis
tissue_expression_ns	hsa-mir-200a	Liver Neoplasms	19167416	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis
tissue_expression_ns	hsa-mir-200b	Liver Neoplasms	19167416	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis
tissue_expression_ns	hsa-mir-200c	Liver Neoplasms	19167416	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis
tissue_expression_ns	hsa-mir-21	Liver Neoplasms	24431000	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	Aberrant miRNA expression response to UV irradiation in human liver cancer cells.
tissue_expression_ns	hsa-mir-21	Liver Neoplasms	19167416	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis
tissue_expression_ns	hsa-mir-26a	Liver Neoplasms	24431000	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	Aberrant miRNA expression response to UV irradiation in human liver cancer cells.
tissue_expression_ns	hsa-mir-34a	Liver Neoplasms	24431000	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	Aberrant miRNA expression response to UV irradiation in human liver cancer cells.
tissue_expression_ns	hsa-mir-429	Liver Neoplasms	19167416	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis
tissue_expression_ns	hsa-mir-18a	Lung Fibrosis	27689473	respiratory system disease	DOID:3770	J84.10	D011658	178500		Altered microRNA expression profiles in lung damage induced by nanosized SiO2.
tissue_expression_ns	hsa-mir-212	Lung Fibrosis	27689473	respiratory system disease	DOID:3770	J84.10	D011658	178500		Altered microRNA expression profiles in lung damage induced by nanosized SiO2.
tissue_expression_ns	hsa-let-7a	Lung Neoplasms	21102586	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a).
tissue_expression_ns	hsa-let-7a	Lung Neoplasms	29371906	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-let-7a	Lung Neoplasms	23365639	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Specifically, let-7 and miR-9 are deregulated in both lung cancers and other solid malignancies.
tissue_expression_ns	hsa-let-7b	Lung Neoplasms	21102586	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a).
tissue_expression_ns	hsa-let-7c	Lung Neoplasms	21102586	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a).
tissue_expression_ns	hsa-let-7c	Lung Neoplasms	29371906	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-let-7d	Lung Neoplasms	21102586	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a).
tissue_expression_ns	hsa-let-7e	Lung Neoplasms	21102586	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a).
tissue_expression_ns	hsa-let-7f	Lung Neoplasms	21102586	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a).
tissue_expression_ns	hsa-let-7g	Lung Neoplasms	20818338	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Four miRNAs (miR-155, miR-25, miR-495 and miR-7g) were expressed differently among these tumors. miR-155 was upregulated only in EGFR/KRAS-negative group, miR-25 was upregulated only in EGFR-positive group and miR-495 was upregulated only in KRAS-positive adenocarcinomas. 
tissue_expression_ns	hsa-let-7g	Lung Neoplasms	21102586	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a).
tissue_expression_ns	hsa-let-7i	Lung Neoplasms	21102586	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a).
tissue_expression_ns	hsa-mir-103	Lung Neoplasms	22576802	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Among them, some have a well-characterized association with cancer progression, e.g. miR-125b, miR-210, miR-103, miR-194 and miR-500. In summary, it is evident from our results that MTA1 functions in regulating the invasive phenotype of lung cancer cells and this regulation may be through altered miRNA expression.
tissue_expression_ns	hsa-mir-125b	Lung Neoplasms	22576802	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Among them, some have a well-characterized association with cancer progression, e.g. miR-125b, miR-210, miR-103, miR-194 and miR-500. In summary, it is evident from our results that MTA1 functions in regulating the invasive phenotype of lung cancer cells and this regulation may be through altered miRNA expression.
tissue_expression_ns	hsa-mir-126	Lung Neoplasms	25124149	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Expression of microRNA miR-126 and miR-200c is associated with prognosis in patients with non-small cell lung cancer.
tissue_expression_ns	hsa-mir-126	Lung Neoplasms	21102586	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a).
tissue_expression_ns	hsa-mir-126	Lung Neoplasms	29371906	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-mir-126	Lung Neoplasms	19493678	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Comparing paired lung cancer tissue with adjacent normal lung parenchyma, hsa-miR-126*, hsa-miR-145, hsa-miR-21, hsa-miR-182, hsa-miR-183 and hsa-miR-210 were found to be the most differentially expressed miRNAs.
tissue_expression_ns	hsa-mir-145	Lung Neoplasms	19493678	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Comparing paired lung cancer tissue with adjacent normal lung parenchyma, hsa-miR-126*, hsa-miR-145, hsa-miR-21, hsa-miR-182, hsa-miR-183 and hsa-miR-210 were found to be the most differentially expressed miRNAs.
tissue_expression_ns	hsa-mir-155	Lung Neoplasms	24574164	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Under clinical conditions, mRNA detection is likely unsuitable for improving sensitivity of EBUS-TBNA-facilitated cancer staging. In contrast,detection of miRNA combined with EBUS-TBNA cytology may improve staging sensitivity.
tissue_expression_ns	hsa-mir-155	Lung Neoplasms	20818338	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Four miRNAs (miR-155, miR-25, miR-495 and miR-7g) were expressed differently among these tumors. miR-155 was upregulated only in EGFR/KRAS-negative group, miR-25 was upregulated only in EGFR-positive group and miR-495 was upregulated only in KRAS-positive adenocarcinomas. 
tissue_expression_ns	hsa-mir-155	Lung Neoplasms	29371906	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-mir-155	Lung Neoplasms	29437031	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Underexpression of miR-486-5p but not Overexpression of miR-156 is Associated with Lung Cancer Stages
tissue_expression_ns	hsa-mir-15a	Lung Neoplasms	21102586	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a).
tissue_expression_ns	hsa-mir-182	Lung Neoplasms	19493678	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Comparing paired lung cancer tissue with adjacent normal lung parenchyma, hsa-miR-126*, hsa-miR-145, hsa-miR-21, hsa-miR-182, hsa-miR-183 and hsa-miR-210 were found to be the most differentially expressed miRNAs.
tissue_expression_ns	hsa-mir-183	Lung Neoplasms	19493678	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Comparing paired lung cancer tissue with adjacent normal lung parenchyma, hsa-miR-126*, hsa-miR-145, hsa-miR-21, hsa-miR-182, hsa-miR-183 and hsa-miR-210 were found to be the most differentially expressed miRNAs.
tissue_expression_ns	hsa-mir-194	Lung Neoplasms	22576802	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Among them, some have a well-characterized association with cancer progression, e.g. miR-125b, miR-210, miR-103, miR-194 and miR-500. In summary, it is evident from our results that MTA1 functions in regulating the invasive phenotype of lung cancer cells and this regulation may be through altered miRNA expression.
tissue_expression_ns	hsa-mir-200b	Lung Neoplasms	29371906	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-mir-200c	Lung Neoplasms	24574164	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Under clinical conditions, mRNA detection is likely unsuitable for improving sensitivity of EBUS-TBNA-facilitated cancer staging. In contrast,detection of miRNA combined with EBUS-TBNA cytology may improve staging sensitivity.
tissue_expression_ns	hsa-mir-200c	Lung Neoplasms	25124150	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Expression of microRNA miR-126 and miR-201c is associated with prognosis in patients with non-small cell lung cancer.
tissue_expression_ns	hsa-mir-202	Lung Neoplasms	21102586	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a).
tissue_expression_ns	hsa-mir-205	Lung Neoplasms	25917317	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	MiR-205 and miR-218 expression is associated with carboplatin chemoresistance and regulation of apoptosis via Mcl-1 and Survivin in lung cancer cells.
tissue_expression_ns	hsa-mir-21	Lung Neoplasms	24574164	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Under clinical conditions, mRNA detection is likely unsuitable for improving sensitivity of EBUS-TBNA-facilitated cancer staging. In contrast,detection of miRNA combined with EBUS-TBNA cytology may improve staging sensitivity.
tissue_expression_ns	hsa-mir-21	Lung Neoplasms	24880588	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Diagnostic value of microRNA-21 in the diagnosis of lung cancer: evidence from a meta-analysis involving 11 studies.
tissue_expression_ns	hsa-mir-21	Lung Neoplasms	21102586	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a).
tissue_expression_ns	hsa-mir-21	Lung Neoplasms	29371906	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-mir-21	Lung Neoplasms	19493678	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Comparing paired lung cancer tissue with adjacent normal lung parenchyma, hsa-miR-126*, hsa-miR-145, hsa-miR-21, hsa-miR-182, hsa-miR-183 and hsa-miR-210 were found to be the most differentially expressed miRNAs.
tissue_expression_ns	hsa-mir-210	Lung Neoplasms	20885442	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	These observations help explain contradictory data regarding miR-210 expression and its putative function in solid tumors.
tissue_expression_ns	hsa-mir-210	Lung Neoplasms	29371906	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-mir-210	Lung Neoplasms	19493678	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Comparing paired lung cancer tissue with adjacent normal lung parenchyma, hsa-miR-126*, hsa-miR-145, hsa-miR-21, hsa-miR-182, hsa-miR-183 and hsa-miR-210 were found to be the most differentially expressed miRNAs.
tissue_expression_ns	hsa-mir-210	Lung Neoplasms	22576802	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Among them, some have a well-characterized association with cancer progression, e.g. miR-125b, miR-210, miR-103, miR-194 and miR-500. In summary, it is evident from our results that MTA1 functions in regulating the invasive phenotype of lung cancer cells and this regulation may be through altered miRNA expression.
tissue_expression_ns	hsa-mir-218	Lung Neoplasms	25917317	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	MiR-205 and miR-218 expression is associated with carboplatin chemoresistance and regulation of apoptosis via Mcl-1 and Survivin in lung cancer cells.
tissue_expression_ns	hsa-mir-25	Lung Neoplasms	20818338	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Four miRNAs (miR-155, miR-25, miR-495 and miR-7g) were expressed differently among these tumors. miR-155 was upregulated only in EGFR/KRAS-negative group, miR-25 was upregulated only in EGFR-positive group and miR-495 was upregulated only in KRAS-positive adenocarcinomas. 
tissue_expression_ns	hsa-mir-25	Lung Neoplasms	21102586	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a).
tissue_expression_ns	hsa-mir-30a	Lung Neoplasms	29371906	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-mir-34a	Lung Neoplasms	24574164	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Under clinical conditions, mRNA detection is likely unsuitable for improving sensitivity of EBUS-TBNA-facilitated cancer staging. In contrast,detection of miRNA combined with EBUS-TBNA cytology may improve staging sensitivity.
tissue_expression_ns	hsa-mir-451	Lung Neoplasms	29371906	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions
tissue_expression_ns	hsa-mir-486	Lung Neoplasms	29437031	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Underexpression of miR-486-5p but not Overexpression of miR-155 is Associated with Lung Cancer Stages
tissue_expression_ns	hsa-mir-495	Lung Neoplasms	20818338	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Four miRNAs (miR-155, miR-25, miR-495 and miR-7g) were expressed differently among these tumors. miR-155 was upregulated only in EGFR/KRAS-negative group, miR-25 was upregulated only in EGFR-positive group and miR-495 was upregulated only in KRAS-positive adenocarcinomas. 
tissue_expression_ns	hsa-mir-500	Lung Neoplasms	22576802	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Among them, some have a well-characterized association with cancer progression, e.g. miR-125b, miR-210, miR-103, miR-194 and miR-500. In summary, it is evident from our results that MTA1 functions in regulating the invasive phenotype of lung cancer cells and this regulation may be through altered miRNA expression.
tissue_expression_ns	hsa-mir-503	Lung Neoplasms	29164842	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-503 is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma andseveral others
tissue_expression_ns	hsa-mir-9	Lung Neoplasms	23365639	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Specifically, let-7 and miR-9 are deregulated in both lung cancers and other solid malignancies.
tissue_expression_ns	hsa-mir-98	Lung Neoplasms	21102586	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a).
tissue_expression_ns	hsa-mir-125a	Lupus Nephritis	26762103	urinary system disease	DOID:0080162	M32.14	D008181			Levels of cell-free miR-125a, miR-150, and miR-155 in the urine supernatant are associated with the expression of LN-Panel biomarkers and some LN measures. These miRNA's may complement, but are unlikely superior to the LN-Panel for estimating concurrent LN activity.
tissue_expression_ns	hsa-mir-127	Lupus Nephritis	26762103	urinary system disease	DOID:0080162	M32.14	D008181			Levels of cell-free miR-125a, miR-150, and miR-155 in the urine supernatant are associated with the expression of LN-Panel biomarkers and some LN measures. These miRNA's may complement, but are unlikely superior to the LN-Panel for estimating concurrent LN activity.
tissue_expression_ns	hsa-mir-145	Lupus Nephritis	26722454	urinary system disease	DOID:0080162	M32.14	D008181			Association of miRNA-145 expression in vascular smooth muscle cells with vascular damages in patients with lupus nephritis.
tissue_expression_ns	hsa-mir-146a	Lupus Nephritis	22295894	urinary system disease	DOID:0080162	M32.14	D008181			Intra-renal expression of miR-638, miR-198 and miR-146a are differentially expressed between LN patients and normal controls. Furthermore, the degree of change in glomerular miR-146a and tubulointerstitial miR-638 expression correlated with clinical disease severity.
tissue_expression_ns	hsa-mir-146a	Lupus Nephritis	26762103	urinary system disease	DOID:0080162	M32.14	D008181			Levels of cell-free miR-125a, miR-150, and miR-155 in the urine supernatant are associated with the expression of LN-Panel biomarkers and some LN measures. These miRNA's may complement, but are unlikely superior to the LN-Panel for estimating concurrent LN activity.
tissue_expression_ns	hsa-mir-150	Lupus Nephritis	26762103	urinary system disease	DOID:0080162	M32.14	D008181			Levels of cell-free miR-125a, miR-150, and miR-155 in the urine supernatant are associated with the expression of LN-Panel biomarkers and some LN measures. These miRNA's may complement, but are unlikely superior to the LN-Panel for estimating concurrent LN activity.
tissue_expression_ns	hsa-mir-155	Lupus Nephritis	26762103	urinary system disease	DOID:0080162	M32.14	D008181			Levels of cell-free miR-125a, miR-150, and miR-155 in the urine supernatant are associated with the expression of LN-Panel biomarkers and some LN measures. These miRNA's may complement, but are unlikely superior to the LN-Panel for estimating concurrent LN activity.
tissue_expression_ns	hsa-mir-198	Lupus Nephritis	22295894	urinary system disease	DOID:0080162	M32.14	D008181			Intra-renal expression of miR-638, miR-198 and miR-146a are differentially expressed between LN patients and normal controls. Furthermore, the degree of change in glomerular miR-146a and tubulointerstitial miR-638 expression correlated with clinical disease severity.
tissue_expression_ns	hsa-mir-638	Lupus Nephritis	22295894	urinary system disease	DOID:0080162	M32.14	D008181			Intra-renal expression of miR-638, miR-198 and miR-146a are differentially expressed between LN patients and normal controls. Furthermore, the degree of change in glomerular miR-146a and tubulointerstitial miR-638 expression correlated with clinical disease severity.
tissue_expression_ns	hsa-mir-223	Lyme Disease	28076897	disease by infectious agent	DOID:11729	A69.2	D008193			MicroRNA Expression Shows Inflammatory Dysregulation and Tumor-Like Proliferative Responses in Joints of Patients With Postinfectious Lyme Arthritis.
tissue_expression_ns	hsa-mir-124-1	Lymphoma	22395483	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	A distinct set of five microRNAs (miR-150, miR-550, miR-124a, miR-518b and miR-539) was shown to be differentially expressed in gastritis as opposed to MALT lymphoma.
tissue_expression_ns	hsa-mir-135a-1	Lymphoma	22490335	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	different expression between small lymphocytic leukemia and lymphoma
tissue_expression_ns	hsa-mir-135a-2	Lymphoma	22490335	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	different expression between small lymphocytic leukemia and lymphoma
tissue_expression_ns	hsa-mir-142	Lymphoma	28031239	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	MicroRNAs 142-3p, miR-155 and miR-203 Are Deregulated in Gastric MALT Lymphomas Compared to Chronic Gastritis.
tissue_expression_ns	hsa-mir-150	Lymphoma	22395483	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	A distinct set of five microRNAs (miR-150, miR-550, miR-124a, miR-518b and miR-539) was shown to be differentially expressed in gastritis as opposed to MALT lymphoma.
tissue_expression_ns	hsa-mir-150	Lymphoma	22490335	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	different expression between small lymphocytic leukemia and lymphoma
tissue_expression_ns	hsa-mir-155	Lymphoma	25265435	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	Differential expression of miR-155 and miR-21 in tumor and stroma cells in diffuse large B-cell lymphoma.
tissue_expression_ns	hsa-mir-155	Lymphoma	23871213	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	The expression ratio of miR-17-5p and miR-155 correlates with grading in canine splenic lymphoma.
tissue_expression_ns	hsa-mir-155	Lymphoma	22776000	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	Although miRNA microarray analysis did not identify statistically significant differentially expressed miRNAs, miRNA-Q-PCR demonstrated statistically significantly differential expression of miR-155, miR-27b, miR-93, miR-29b and miR-92a between tumor-stage MF and C-ALCL.
tissue_expression_ns	hsa-mir-155	Lymphoma	28031239	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	MicroRNAs 142-3p, miR-155 and miR-203 Are Deregulated in Gastric MALT Lymphomas Compared to Chronic Gastritis.
tissue_expression_ns	hsa-mir-184	Lymphoma	22490335	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	different expression between small lymphocytic leukemia and lymphoma
tissue_expression_ns	hsa-mir-203	Lymphoma	28031239	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	MicroRNAs 142-3p, miR-155 and miR-203 Are Deregulated in Gastric MALT Lymphomas Compared to Chronic Gastritis.
tissue_expression_ns	hsa-mir-21	Lymphoma	25265435	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	Differential expression of miR-155 and miR-21 in tumor and stroma cells in diffuse large B-cell lymphoma.
tissue_expression_ns	hsa-mir-27b	Lymphoma	22776000	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	Although miRNA microarray analysis did not identify statistically significant differentially expressed miRNAs, miRNA-Q-PCR demonstrated statistically significantly differential expression of miR-155, miR-27b, miR-93, miR-29b and miR-92a between tumor-stage MF and C-ALCL.
tissue_expression_ns	hsa-mir-29b	Lymphoma	22776000	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	Although miRNA microarray analysis did not identify statistically significant differentially expressed miRNAs, miRNA-Q-PCR demonstrated statistically significantly differential expression of miR-155, miR-27b, miR-93, miR-29b and miR-92a between tumor-stage MF and C-ALCL.
tissue_expression_ns	hsa-mir-342	Lymphoma	22490335	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	different expression between small lymphocytic leukemia and lymphoma
tissue_expression_ns	hsa-mir-363	Lymphoma	22490335	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	different expression between small lymphocytic leukemia and lymphoma
tissue_expression_ns	hsa-mir-518b	Lymphoma	22395483	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	A distinct set of five microRNAs (miR-150, miR-550, miR-124a, miR-518b and miR-539) was shown to be differentially expressed in gastritis as opposed to MALT lymphoma.
tissue_expression_ns	hsa-mir-539	Lymphoma	22395483	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	A distinct set of five microRNAs (miR-150, miR-550, miR-124a, miR-518b and miR-539) was shown to be differentially expressed in gastritis as opposed to MALT lymphoma.
tissue_expression_ns	hsa-mir-550a-1	Lymphoma	22395483	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	A distinct set of five microRNAs (miR-150, miR-550, miR-124a, miR-518b and miR-539) was shown to be differentially expressed in gastritis as opposed to MALT lymphoma.
tissue_expression_ns	hsa-mir-550a-2	Lymphoma	22395483	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	A distinct set of five microRNAs (miR-150, miR-550, miR-124a, miR-518b and miR-539) was shown to be differentially expressed in gastritis as opposed to MALT lymphoma.
tissue_expression_ns	hsa-mir-708	Lymphoma	22490335	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	different expression between small lymphocytic leukemia and lymphoma
tissue_expression_ns	hsa-mir-92a	Lymphoma	22776000	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	Although miRNA microarray analysis did not identify statistically significant differentially expressed miRNAs, miRNA-Q-PCR demonstrated statistically significantly differential expression of miR-155, miR-27b, miR-93, miR-29b and miR-92a between tumor-stage MF and C-ALCL.
tissue_expression_ns	hsa-mir-93	Lymphoma	22776000	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	Although miRNA microarray analysis did not identify statistically significant differentially expressed miRNAs, miRNA-Q-PCR demonstrated statistically significantly differential expression of miR-155, miR-27b, miR-93, miR-29b and miR-92a between tumor-stage MF and C-ALCL.
tissue_expression_ns	hsa-mir-155	Lymphoma, Burkitt	16235244	disease of cellular proliferation	DOID:8584	C83.7	D002051	113970	HP:0030080	Expression of BIC and miR-155 in 3 latency type III EBV-positive BL cell lines and in all primary PTLD cases suggests a possible role for EBV latency type III specific proteins in the induction of BIC expression.
tissue_expression_ns	hsa-mir-26a	Lymphoma, Burkitt	18713946	disease of cellular proliferation	DOID:8584	C83.7	D002051	113970	HP:0030080	Interestingly, miR-26a was also found to be deregulated in primary human Burkitt lymphoma samples, thereby probably being of clinical relevance.
tissue_expression_ns	hsa-mir-129-2	Lymphoma, Large B-Cell	24358187			C83.3	D016403	109565		MicroRNA profiling of primary cutaneous large B-cell lymphomas.
tissue_expression_ns	hsa-mir-135b	Lymphoma, Large B-Cell	23801630			C83.3	D016403	109565		MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma.
tissue_expression_ns	hsa-mir-146a	Lymphoma, Large B-Cell	23801630			C83.3	D016403	109565		MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma.
tissue_expression_ns	hsa-mir-155	Lymphoma, Large B-Cell	23801630			C83.3	D016403	109565		MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma.
tissue_expression_ns	hsa-mir-214	Lymphoma, Large B-Cell	24358187			C83.3	D016403	109565		MicroRNA profiling of primary cutaneous large B-cell lymphomas.
tissue_expression_ns	hsa-mir-31	Lymphoma, Large B-Cell	24358187			C83.3	D016403	109565		MicroRNA profiling of primary cutaneous large B-cell lymphomas.
tissue_expression_ns	hsa-mir-512	Lymphoma, Large B-Cell	23801630			C83.3	D016403	109565		MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma.
tissue_expression_ns	hsa-mir-708	Lymphoma, Large B-Cell	23801630			C83.3	D016403	109565		MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma.
tissue_expression_ns	hsa-mir-886	Lymphoma, Large B-Cell	23801630			C83.3	D016403	109565		MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma.
tissue_expression_ns	hsa-mir-9	Lymphoma, Large B-Cell	24358187			C83.3	D016403	109565		MicroRNA profiling of primary cutaneous large B-cell lymphomas.
tissue_expression_ns	hsa-mir-127	Lymphoma, Large B-Cell, Diffuse	19287466	disease of cellular proliferation	DOID:0050745	C83.3	D016403	109565		Specific expression of miR-17-5p and miR-127 in testicular and central nervous system diffuse large B-cell lymphoma.
tissue_expression_ns	hsa-mir-17	Lymphoma, Large B-Cell, Diffuse	19287466	disease of cellular proliferation	DOID:0050745	C83.3	D016403	109565		Specific expression of miR-17-5p and miR-127 in testicular and central nervous system diffuse large B-cell lymphoma.
tissue_expression_ns	hsa-mir-23a	Lymphoma, Large B-Cell, Diffuse	24659264	disease of cellular proliferation	DOID:0050745	C83.3	D016403	109565		MicroRNA-23a expression in paraffin-embedded specimen correlates with overall survival of diffuse large B-cell lymphoma.
tissue_expression_ns	hsa-mir-17	Lymphoproliferative Disorders	25130212			D47.Z1	D008232			Unsupervised nonhierarchical clustering of the viral and cellular microRNAome distinguished non-EBV-associated from EBV-associated samples and identified a separate group of EBV-associated pCNS PTLD that displayed reduced levels of B cell lymphoma associated oncomiRs such as hsa-miR-155, -21, -221 and the hsa-miR-17-92 cluster.
tissue_expression_ns	hsa-mir-181b	Male Infertility	25141839	reproductive system disease	DOID:12336	N46.9	D007248		HP:0003251	The expression of three out of five selected miRNAs, including miR-34a, miR-181b and miR-122a, showed some degrees of changes following exposure to oxidative stress.
tissue_expression_ns	hsa-mir-29	Malignant Neoplasms [unspecific]	28063172			C80.1	D009369			Prognostic value of the MicroRNA-29 family in multiple human cancers: A meta-analysis and systematic review.
tissue_expression_ns	hsa-mir-223	Mastitis	28831974	thoracic disease	DOID:10690		D008413			Expression profiles of miRNAs from bovine mammary glands in response to Streptococcus agalactiae-induced mastitis.
tissue_expression_ns	hsa-mir-10b	Medulloblastoma	18973228	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	miR-10b: different expression in tumors overexpression or not ErbB2
tissue_expression_ns	hsa-mir-125b-1	Medulloblastoma	18973228	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	miR-125b: different expression in tumors overexpression or not ErbB2
tissue_expression_ns	hsa-mir-125b-2	Medulloblastoma	18973228	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	miR-125b: different expression in tumors overexpression or not ErbB2
tissue_expression_ns	hsa-mir-135a-1	Medulloblastoma	18973228	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	miR-135a: different expression in tumors overexpression or not ErbB2
tissue_expression_ns	hsa-mir-135a-2	Medulloblastoma	18973228	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	miR-135a: different expression in tumors overexpression or not ErbB2
tissue_expression_ns	hsa-mir-135b	Medulloblastoma	18973228	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	miR-135b: different expression in tumors overexpression or not ErbB2
tissue_expression_ns	hsa-mir-153-1	Medulloblastoma	18973228	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	miR-153: different expression in tumors overexpression or not ErbB2
tissue_expression_ns	hsa-mir-153-2	Medulloblastoma	18973228	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	miR-153: different expression in tumors overexpression or not ErbB2
tissue_expression_ns	hsa-mir-181b-1	Medulloblastoma	18973228	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	miR-181b: different expression in tumors overexpression or not c-Myc
tissue_expression_ns	hsa-mir-181b-2	Medulloblastoma	18973228	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	miR-181b: different expression in tumors overexpression or not c-Myc
tissue_expression_ns	hsa-mir-199b	Medulloblastoma	18973228	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	miR-199b: different expression in tumors overexpression or not ErbB2
tissue_expression_ns	hsa-mir-211	Medulloepithelioma	25807141	disease of cellular proliferation	DOID:4790		D018242		HP:0030071	We report significantly dysregulated miRNAs in intraocular ME tumors, which exhibited abnormal profiles in other cancers as well such as retinoblastoma and glioblastoma. Pathway analysis of all dysregulated miRNAs shared commonalities with other cancer pathways.
tissue_expression_ns	hsa-mir-509	Medulloepithelioma	25807141	disease of cellular proliferation	DOID:4790		D018242		HP:0030071	We report significantly dysregulated miRNAs in intraocular ME tumors, which exhibited abnormal profiles in other cancers as well such as retinoblastoma and glioblastoma. Pathway analysis of all dysregulated miRNAs shared commonalities with other cancer pathways.
tissue_expression_ns	hsa-let-7a	Melanoma	23377970	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222.
tissue_expression_ns	hsa-let-7b	Melanoma	18477892	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	The most significant discriminators were let-7b and miR-199a, and the expression of these miRNAs was validated by quantitative PCR.
tissue_expression_ns	hsa-let-7b	Melanoma	23377970	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222.
tissue_expression_ns	hsa-mir-125b	Melanoma	27566021	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MicroRNA dysregulation in melanoma.
tissue_expression_ns	hsa-mir-146a	Melanoma	27311960	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-146a controls melanoma progression in a dual way, promoting growth and inhibiting dissemination
tissue_expression_ns	hsa-mir-148	Melanoma	23377970	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222.
tissue_expression_ns	hsa-mir-150	Melanoma	27566021	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MicroRNA dysregulation in melanoma.
tissue_expression_ns	hsa-mir-155	Melanoma	23377970	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222.
tissue_expression_ns	hsa-mir-155	Melanoma	27565163	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Expression of natural killer cell regulatory microRNA by uveal melanoma cancer stem cells.
tissue_expression_ns	hsa-mir-155	Melanoma	27566021	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MicroRNA dysregulation in melanoma.
tissue_expression_ns	hsa-mir-182	Melanoma	23377970	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222.
tissue_expression_ns	hsa-mir-182	Melanoma	26273328	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Clinical analyses demonstrated the link of miR-182 expression to poor prognosis in cancer patients.
tissue_expression_ns	hsa-mir-199a	Melanoma	18477892	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	The most significant discriminators were let-7b and miR-199a, and the expression of these miRNAs was validated by quantitative PCR.
tissue_expression_ns	hsa-mir-199a	Melanoma	26812476	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Five miRNAs (miR-214, miR146b, miR-143, miR-199a  and miR-134) were found to be differentially expressed in M3/ D3 UM tumors.
tissue_expression_ns	hsa-mir-200b	Melanoma	26743475	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-10b and miR-200b showed independent prognostic value (P=0.002 and 0.047, respectively) in multivariable analysis alongside known clinico-pathological prognostic features
tissue_expression_ns	hsa-mir-200c	Melanoma	23377970	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222.
tissue_expression_ns	hsa-mir-200c	Melanoma	27469124	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR expression profiles can be measured in indeterminate Spitz tumors and correlate with markers of malignant potential.
tissue_expression_ns	hsa-mir-203	Melanoma	24023765	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	we found extensive sequence variations (isomiRs) and other non-coding small RNAs revealing a complex melanoma transcriptome. Deep-sequencing small RNAs directly from clinically defined specimens provides a robust strategy to improve melanoma diagnostics.
tissue_expression_ns	hsa-mir-204	Melanoma	24023765	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	we found extensive sequence variations (isomiRs) and other non-coding small RNAs revealing a complex melanoma transcriptome. Deep-sequencing small RNAs directly from clinically defined specimens provides a robust strategy to improve melanoma diagnostics.
tissue_expression_ns	hsa-mir-204	Melanoma	20302635	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Although the number of cases is small, positive lymph node status in the two age groups was characterized by the statistically significant expression of hsa-miR-30a* and hsa-miR-204 (F-test, p-value < 0.001).
tissue_expression_ns	hsa-mir-205	Melanoma	24023765	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	we found extensive sequence variations (isomiRs) and other non-coding small RNAs revealing a complex melanoma transcriptome. Deep-sequencing small RNAs directly from clinically defined specimens provides a robust strategy to improve melanoma diagnostics.
tissue_expression_ns	hsa-mir-205	Melanoma	27566021	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MicroRNA dysregulation in melanoma.
tissue_expression_ns	hsa-mir-21	Melanoma	27566021	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MicroRNA dysregulation in melanoma.
tissue_expression_ns	hsa-mir-211	Melanoma	24023765	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	we found extensive sequence variations (isomiRs) and other non-coding small RNAs revealing a complex melanoma transcriptome. Deep-sequencing small RNAs directly from clinically defined specimens provides a robust strategy to improve melanoma diagnostics.
tissue_expression_ns	hsa-mir-211	Melanoma	23377970	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222.
tissue_expression_ns	hsa-mir-211	Melanoma	27566021	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MicroRNA dysregulation in melanoma.
tissue_expression_ns	hsa-mir-214	Melanoma	23377970	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222.
tissue_expression_ns	hsa-mir-221	Melanoma	23377970	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222.
tissue_expression_ns	hsa-mir-222	Melanoma	23377970	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222.
tissue_expression_ns	hsa-mir-23a	Melanoma	23377970	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222.
tissue_expression_ns	hsa-mir-23b	Melanoma	24023765	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	we found extensive sequence variations (isomiRs) and other non-coding small RNAs revealing a complex melanoma transcriptome. Deep-sequencing small RNAs directly from clinically defined specimens provides a robust strategy to improve melanoma diagnostics.
tissue_expression_ns	hsa-mir-23b	Melanoma	23377970	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222.
tissue_expression_ns	hsa-mir-26a	Melanoma	24023765	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	we found extensive sequence variations (isomiRs) and other non-coding small RNAs revealing a complex melanoma transcriptome. Deep-sequencing small RNAs directly from clinically defined specimens provides a robust strategy to improve melanoma diagnostics.
tissue_expression_ns	hsa-mir-26b	Melanoma	24023765	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	we found extensive sequence variations (isomiRs) and other non-coding small RNAs revealing a complex melanoma transcriptome. Deep-sequencing small RNAs directly from clinically defined specimens provides a robust strategy to improve melanoma diagnostics.
tissue_expression_ns	hsa-mir-301a	Melanoma	27855389	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Expression of MicroRNA-301a and its Functional Roles in Malignant Melanoma.
tissue_expression_ns	hsa-mir-30a	Melanoma	20302635	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Although the number of cases is small, positive lymph node status in the two age groups was characterized by the statistically significant expression of hsa-miR-30a* and hsa-miR-204 (F-test, p-value < 0.001).
tissue_expression_ns	hsa-mir-320	Melanoma	26264058	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	hsa-miR-519, "hsa-miR-431" and "hsa-miR-320c" are possible novel predictions for renal cancer, lung cancer and melanoma, respectively.
tissue_expression_ns	hsa-mir-107	Meningioma	28349893	disease of cellular proliferation	DOID:3565	D32.9	D008579	607174	HP:0002858	Expression of miRNA-21, miRNA-107, miRNA-137 and miRNA-29b in meningioma.
tissue_expression_ns	hsa-mir-137	Meningioma	28349893	disease of cellular proliferation	DOID:3565	D32.9	D008579	607174	HP:0002858	Expression of miRNA-21, miRNA-107, miRNA-137 and miRNA-29b in meningioma.
tissue_expression_ns	hsa-mir-21	Meningioma	28349893	disease of cellular proliferation	DOID:3565	D32.9	D008579	607174	HP:0002858	Expression of miRNA-21, miRNA-107, miRNA-137 and miRNA-29b in meningioma.
tissue_expression_ns	hsa-mir-29b	Meningioma	28349893	disease of cellular proliferation	DOID:3565	D32.9	D008579	607174	HP:0002858	Expression of miRNA-21, miRNA-107, miRNA-137 and miRNA-29b in meningioma.
tissue_expression_ns	hsa-mir-124	Mesial Temporal Lobe Epilepsy	23315173			G40.209	D004833	608096		Expression patterns of miR-124, miR-134, miR-132, and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy.
tissue_expression_ns	hsa-mir-128a	Mesial Temporal Lobe Epilepsy	27695061			G40.209	D004833	608096		Identification of microRNAs with Dysregulated Expression in Status Epilepticus Induced Epileptogenesis.
tissue_expression_ns	hsa-mir-132	Mesial Temporal Lobe Epilepsy	23315173			G40.209	D004833	608096		Expression patterns of miR-124, miR-134, miR-132, and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy.
tissue_expression_ns	hsa-mir-134	Mesial Temporal Lobe Epilepsy	23315173			G40.209	D004833	608096		Expression patterns of miR-124, miR-134, miR-132, and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy.
tissue_expression_ns	hsa-mir-196b	Mesial Temporal Lobe Epilepsy	27695061			G40.209	D004833	608096		Identification of microRNAs with Dysregulated Expression in Status Epilepticus Induced Epileptogenesis.
tissue_expression_ns	hsa-mir-21	Mesial Temporal Lobe Epilepsy	23315173			G40.209	D004833	608096		Expression patterns of miR-124, miR-134, miR-132, and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy.
tissue_expression_ns	hsa-mir-352	Mesial Temporal Lobe Epilepsy	27695061			G40.209	D004833	608096		Identification of microRNAs with Dysregulated Expression in Status Epilepticus Induced Epileptogenesis.
tissue_expression_ns	hsa-mir-103a	Mesothelioma	25469901	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	the use of biomarkers of different molecular classes might be a reasonable approach to assemble a biomarker panel.
tissue_expression_ns	hsa-mir-126	Mesothelioma	26765063	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	Subject to validation of the current results in further larger studies, miR-21 and miR-126 profiling could be an effective and reliable tool for the diagnosis of MM in pleural effusions complementary to cytology evaluation.
tissue_expression_ns	hsa-mir-182	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	dysregulated
tissue_expression_ns	hsa-mir-21	Mesothelioma	26765063	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	Subject to validation of the current results in further larger studies, miR-21 and miR-126 profiling could be an effective and reliable tool for the diagnosis of MM in pleural effusions complementary to cytology evaluation.
tissue_expression_ns	hsa-mir-214	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	dysregulated
tissue_expression_ns	hsa-mir-497	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	dysregulated
tissue_expression_ns	hsa-mir-7-1	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	dysregulated
tissue_expression_ns	hsa-mir-7-2	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	dysregulated
tissue_expression_ns	hsa-mir-7-3	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	dysregulated
tissue_expression_ns	hsa-let-7c	Mitral Valve Disease	29315310			I05				Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d  in naturally occurring canine myxomatous mitral valve disease
tissue_expression_ns	hsa-mir-17	Mitral Valve Disease	29315310			I05				Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d  in naturally occurring canine myxomatous mitral valve disease
tissue_expression_ns	hsa-mir-20a	Mitral Valve Disease	29315310			I05				Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d  in naturally occurring canine myxomatous mitral valve disease
tissue_expression_ns	hsa-mir-30d	Mitral Valve Disease	29315310			I05				Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d  in naturally occurring canine myxomatous mitral valve disease
tissue_expression_ns	hsa-mir-223	Multiple Myeloma	27023728	disease of cellular proliferation	DOID:9538		D009101	254500	HP:0006775	miR-223 expression in MM-BMMSCs was reduced by the presence of MM cells
tissue_expression_ns	hsa-let-7a	Multiple Sclerosis	25487315	nervous system disease	DOID:2377	G35	D009103	PS126200		some miRNA subsets may be potential biomarkers for MS activity.
tissue_expression_ns	hsa-mir-26a	Multiple Sclerosis	24792898	nervous system disease	DOID:2377	G35	D009103	PS126200		miR-326 and miR-26a, two potential markers for diagnosis of relapse and remission phases in patient with relapsing-remitting multiple sclerosis.
tissue_expression_ns	hsa-mir-26a	Multiple Sclerosis	27310932	nervous system disease	DOID:2377	G35	D009103	PS126200		down-regulation of miR-155 and miR-26a was seen in MS patients during and after natalizumab therapy.
tissue_expression_ns	hsa-mir-326	Multiple Sclerosis	24792898	nervous system disease	DOID:2377	G35	D009103	PS126200		miR-326 and miR-26a, two potential markers for diagnosis of relapse and remission phases in patient with relapsing-remitting multiple sclerosis.
tissue_expression_ns	hsa-mir-648a	Multiple Sclerosis	25487315	nervous system disease	DOID:2377	G35	D009103	PS126200		some miRNA subsets may be potential biomarkers for MS activity.
tissue_expression_ns	hsa-mir-92a	Multiple Sclerosis	25487315	nervous system disease	DOID:2377	G35	D009103	PS126200		some miRNA subsets may be potential biomarkers for MS activity.
tissue_expression_ns	hsa-mir-202	Multiple System Atrophy	24981430	nervous system disease	DOID:4752	G90.3	D019578	146500		Altered expression of miR-202 in cerebellum of multiple-system atrophy.
tissue_expression_ns	hsa-mir-21	Muscle Atrophy	24891504			M62.5	D009133		HP:0100295	Among the different miRNAs, microRNA-206 and -21 were the most induced in denervated muscles.
tissue_expression_ns	hsa-mir-206	Muscle Diseases [unspecific]	25703017			M63.80	D009135			Thirty-six miRNAs were differentially expressed between prenatal and postnatal stages of muscle development including several myomiRs (miR-1, miR-206 and let-7  families).
tissue_expression_ns	hsa-mir-1	Muscular Dystrophy	26398013			G71.0	D009136	310200	HP:0003560	whereas down-regulation of myogenic miRNAs, including miR-1 and miR-206, is associated with inhibition of muscle regeneration.
tissue_expression_ns	hsa-mir-195	Muscular Dystrophy	27651778			G71.0	D009136	310200	HP:0003560	At the epigenetic level, miRNAs are thought to be highly involved in the pathophysiological progress of denervated muscles
tissue_expression_ns	hsa-mir-214	Muscular Dystrophy	27651778			G71.0	D009136	310200	HP:0003560	At the epigenetic level, miRNAs are thought to be highly involved in the pathophysiological progress of denervated muscles
tissue_expression_ns	hsa-mir-221	Muscular Dystrophy	27651778			G71.0	D009136	310200	HP:0003560	At the epigenetic level, miRNAs are thought to be highly involved in the pathophysiological progress of denervated muscles
tissue_expression_ns	hsa-mir-222	Muscular Dystrophy	27651778			G71.0	D009136	310200	HP:0003560	At the epigenetic level, miRNAs are thought to be highly involved in the pathophysiological progress of denervated muscles
tissue_expression_ns	hsa-mir-320	Muscular Dystrophy	27651778			G71.0	D009136	310200	HP:0003560	At the epigenetic level, miRNAs are thought to be highly involved in the pathophysiological progress of denervated muscles
tissue_expression_ns	hsa-mir-330	Muscular Dystrophy, Facioscapulohumeral	25692472	musculoskeletal system disease	DOID:11727	G71.0	D020391	158900		This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated.
tissue_expression_ns	hsa-mir-331	Muscular Dystrophy, Facioscapulohumeral	25692472	musculoskeletal system disease	DOID:11727	G71.0	D020391	158900		This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated.
tissue_expression_ns	hsa-mir-34a	Muscular Dystrophy, Facioscapulohumeral	25692472	musculoskeletal system disease	DOID:11727	G71.0	D020391	158900		This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated.
tissue_expression_ns	hsa-mir-380	Muscular Dystrophy, Facioscapulohumeral	25692472	musculoskeletal system disease	DOID:11727	G71.0	D020391	158900		This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated.
tissue_expression_ns	hsa-mir-516b	Muscular Dystrophy, Facioscapulohumeral	25692472	musculoskeletal system disease	DOID:11727	G71.0	D020391	158900		This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated.
tissue_expression_ns	hsa-mir-517	Muscular Dystrophy, Facioscapulohumeral	25692472	musculoskeletal system disease	DOID:11727	G71.0	D020391	158900		This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated.
tissue_expression_ns	hsa-mir-582	Muscular Dystrophy, Facioscapulohumeral	25692472	musculoskeletal system disease	DOID:11727	G71.0	D020391	158900		This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated.
tissue_expression_ns	hsa-mir-625	Muscular Dystrophy, Facioscapulohumeral	25692472	musculoskeletal system disease	DOID:11727	G71.0	D020391	158900		This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated.
tissue_expression_ns	hsa-mir-146a	Mycobacterium Avium Complex Disease	24462562	disease by infectious agent	DOID:2755	A31.2	D015270			Analysis of miRNA expression profiling in human macrophages responding to Mycobacterium infection: induction of the immune regulator miR-146a.
tissue_expression_ns	hsa-mir-155	Mycosis Fungoides	25698383			C84.00	D009182			These results by identifying a number of differentially expressed microRNAs add further insight into the molecular pathogenesis of folliculotropic MF and large cell transformation of MF.
tissue_expression_ns	hsa-mir-181b	Mycosis Fungoides	25698383			C84.00	D009182			These results by identifying a number of differentially expressed microRNAs add further insight into the molecular pathogenesis of folliculotropic MF and large cell transformation of MF.
tissue_expression_ns	hsa-mir-223	Mycosis Fungoides	25698383			C84.00	D009182			These results by identifying a number of differentially expressed microRNAs add further insight into the molecular pathogenesis of folliculotropic MF and large cell transformation of MF.
tissue_expression_ns	hsa-mir-326	Mycosis Fungoides	25698383			C84.00	D009182			These results by identifying a number of differentially expressed microRNAs add further insight into the molecular pathogenesis of folliculotropic MF and large cell transformation of MF.
tissue_expression_ns	hsa-mir-150	Myeloma	28458781			C90.0	D009101	254500		MicroRNA expression patterns and target prediction in multiple myeloma development and malignancy.
tissue_expression_ns	hsa-mir-150	Myeloproliferative Neoplasms	23343777	disease of cellular proliferation	DOID:2226	D47.1		616871		An aberrant expression of miRNAs 10a and 150 could be demonstrated for essential thrombocythemia and PMF as well as for polycythemia vera and PMF, respectively. The expression of miR-150 could further be shown to correlate with both JAK2 allele burden and peripheral blood counts.
tissue_expression_ns	hsa-mir-1-1	Myocardial Infarction	21386882	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	miR-1, miR-29b and miR-98 dysregulated.
tissue_expression_ns	hsa-mir-1-2	Myocardial Infarction	21386882	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	miR-1, miR-29b and miR-98 dysregulated.
tissue_expression_ns	hsa-mir-133b	Myocardial Infarction	20075508	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	dysregulation
tissue_expression_ns	hsa-mir-150	Myocardial Infarction	20075508	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	dysregulation
tissue_expression_ns	hsa-mir-186	Myocardial Infarction	20075508	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	dysregulation
tissue_expression_ns	hsa-mir-21	Myocardial Infarction	19706597	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	hsa-mir-21:a remarkable example of MicroRNA expression signature; downregulated in infarcted areas,  upregulated in border areas
tissue_expression_ns	hsa-mir-21	Myocardial Infarction	21956146	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	deregulated
tissue_expression_ns	hsa-mir-210	Myocardial Infarction	20075508	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	dysregulation
tissue_expression_ns	hsa-mir-29a	Myocardial Infarction	21956146	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	deregulated
tissue_expression_ns	hsa-mir-29b-1	Myocardial Infarction	21386882	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	miR-1, miR-29b and miR-98 dysregulated.
tissue_expression_ns	hsa-mir-29b-2	Myocardial Infarction	21386882	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	miR-1, miR-29b and miR-98 dysregulated.
tissue_expression_ns	hsa-mir-451a	Myocardial Infarction	20075508	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	dysregulation
tissue_expression_ns	hsa-mir-98	Myocardial Infarction	21386882	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	miR-1, miR-29b and miR-98 dysregulated.
tissue_expression_ns	hsa-mir-1	Myocardial Ischemic-Reperfusion Injury	26738985				D015428			Of the 17 miRs, 9 miRs, including miR-1, miR-21, miR-24, and miR-195, which are related to apoptosis, exhibited different expression patterns in the RIPerc group compared with the control.
tissue_expression_ns	hsa-mir-195	Myocardial Ischemic-Reperfusion Injury	26738985				D015428			Of the 17 miRs, 9 miRs, including miR-1, miR-21, miR-24, and miR-195, which are related to apoptosis, exhibited different expression patterns in the RIPerc group compared with the control.
tissue_expression_ns	hsa-mir-1	Myotonic Muscular Dystrophy	28078570			G71.11	D009223	160900		Micro-RNA expression in muscle and fiber morphometry in myotonic dystrophy type 1.
tissue_expression_ns	hsa-mir-133a	Myotonic Muscular Dystrophy	28078570			G71.11	D009223	160900		Micro-RNA expression in muscle and fiber morphometry in myotonic dystrophy type 1.
tissue_expression_ns	hsa-mir-133b	Myotonic Muscular Dystrophy	28078570			G71.11	D009223	160900		Micro-RNA expression in muscle and fiber morphometry in myotonic dystrophy type 1.
tissue_expression_ns	hsa-mir-206	Myotonic Muscular Dystrophy	28078570			G71.11	D009223	160900		Micro-RNA expression in muscle and fiber morphometry in myotonic dystrophy type 1.
tissue_expression_ns	hsa-mir-23b	Myotonic Muscular Dystrophy	24412363			G71.11	D009223	160900		The Mef2 transcription network is disrupted in myotonic dystrophy heart tissue,dramatically altering miRNA and mRNA expression.
tissue_expression_ns	hsa-mir-1290	Necrotizing Enterocolitis	26274503	gastrointestinal system disease	DOID:8677	K55.3	D020345			The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology.
tissue_expression_ns	hsa-mir-194	Necrotizing Enterocolitis	26274503	gastrointestinal system disease	DOID:8677	K55.3	D020345			The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology.
tissue_expression_ns	hsa-mir-203	Necrotizing Enterocolitis	26274503	gastrointestinal system disease	DOID:8677	K55.3	D020345			The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology.
tissue_expression_ns	hsa-mir-21	Necrotizing Enterocolitis	26274503	gastrointestinal system disease	DOID:8677	K55.3	D020345			The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology.
tissue_expression_ns	hsa-mir-31	Necrotizing Enterocolitis	26274503	gastrointestinal system disease	DOID:8677	K55.3	D020345			The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology.
tissue_expression_ns	hsa-mir-431	Necrotizing Enterocolitis	26274503	gastrointestinal system disease	DOID:8677	K55.3	D020345			The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology.
tissue_expression_ns	hsa-mir-451	Necrotizing Enterocolitis	26274503	gastrointestinal system disease	DOID:8677	K55.3	D020345			The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology.
tissue_expression_ns	hsa-let-7	Neoplasms [unspecific]	25998712			C80.1	D009369			together with the recent identification of novel miRNA regulatory factors and pathways, highlights the importance of miRNA dysregulation in cancer.
tissue_expression_ns	hsa-let-7a	Neoplasms [unspecific]	27623940			C80.1	D009369			Aberrant microRNA expression in tumor mycosis fungoides.
tissue_expression_ns	hsa-mir-10b	Neoplasms [unspecific]	28864233			C80.1	D009369			MicroRNA-10b and the clinical outcomes of various cancers: A systematic review and meta-analysis.
tissue_expression_ns	hsa-mir-125b	Neoplasms [unspecific]	26407906			C80.1	D009369			The aberrant expression of miR-125 familyis tightly related to tumorigenesis and tumor development.
tissue_expression_ns	hsa-mir-126	Neoplasms [unspecific]	28536479			C80.1	D009369			Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease.
tissue_expression_ns	hsa-mir-1267	Neoplasms [unspecific]	27623940			C80.1	D009369			Aberrant microRNA expression in tumor mycosis fungoides.
tissue_expression_ns	hsa-mir-128	Neoplasms [unspecific]	24515752			C80.1	D009369			Microvesicle-associated microRNA expression is altered upon particulate matter exposure in healthy workers and in A549 cells.
tissue_expression_ns	hsa-mir-1280	Neoplasms [unspecific]	23936320			C80.1	D009369			Characterization of microRNA expression profiles and the discovery of novel microRNAs involved in cancer during human embryonic development.
tissue_expression_ns	hsa-mir-1282	Neoplasms [unspecific]	27623940			C80.1	D009369			Aberrant microRNA expression in tumor mycosis fungoides.
tissue_expression_ns	hsa-mir-133b	Neoplasms [unspecific]	25075017			C80.1	D009369			Prognostic microRNA expression signature from examination of colorectal primary and metastatic tumors.
tissue_expression_ns	hsa-mir-141	Neoplasms [unspecific]	25789530			C80.1	D009369			miR-141 as a prognostic and diagnostic biomarker in different types of cancer
tissue_expression_ns	hsa-mir-141	Neoplasms [unspecific]	26828359			C80.1	D009369			microRNA (miR)-141 is aberrantly expressed in many human malignant tumors
tissue_expression_ns	hsa-mir-143	Neoplasms [unspecific]	24974841			C80.1	D009369			Using microRNA expression profiles the authors were able to distinguish peritumoural tissues according to distance from the primary tumour site. Future application of the method may prove to be useful in early detection of the altered epigenetic regulation in tissue fields representing normal phenotype. This may be helpful in cancer risk assessment and prevention.
tissue_expression_ns	hsa-mir-143	Neoplasms [unspecific]	20064147			C80.1	D009369			Overall, the current study suggests that miR-143 is ubiquitously expressed among tissues and is likely to be involved in the regulation of cell proliferation and apoptosis.
tissue_expression_ns	hsa-mir-145	Neoplasms [unspecific]	24609385			C80.1	D009369			Together, our probabilistic approach of integrating expression and sequence scores establishes a functional link between the aberrant miRNA and mRNA expression, which was previously under-appreciated due to the methodological differences.
tissue_expression_ns	hsa-mir-145	Neoplasms [unspecific]	25792469			C80.1	D009369			In conclusion, our findings suggest that miR-145 expression is associated with overall survival (OS) in cancer patients and can serve as a promising biomarker for monitoring prognosis.
tissue_expression_ns	hsa-mir-148a	Neoplasms [unspecific]	27390598			C80.1	D009369			Mir-148a  is aberrantly expressed in various cancers and has been identified as an oncogenic or tumor suppressor with crucial roles in the molecular mechanisms of oncogenesis.
tissue_expression_ns	hsa-mir-15	Neoplasms [unspecific]	25998712			C80.1	D009369			together with the recent identification of novel miRNA regulatory factors and pathways, highlights the importance of miRNA dysregulation in cancer.
tissue_expression_ns	hsa-mir-155	Neoplasms [unspecific]	24824925			C80.1	D009369			miR-155 as a diagnostic and prognostic marker in hematological and solid malignancies
tissue_expression_ns	hsa-mir-155	Neoplasms [unspecific]	24974841			C80.1	D009369			Using microRNA expression profiles the authors were able to distinguish peritumoural tissues according to distance from the primary tumour site. Future application of the method may prove to be useful in early detection of the altered epigenetic regulation in tissue fields representing normal phenotype. This may be helpful in cancer risk assessment and prevention.
tissue_expression_ns	hsa-mir-155	Neoplasms [unspecific]	24609385			C80.1	D009369			Together, our probabilistic approach of integrating expression and sequence scores establishes a functional link between the aberrant miRNA and mRNA expression, which was previously under-appreciated due to the methodological differences.
tissue_expression_ns	hsa-mir-16	Neoplasms [unspecific]	25998712			C80.1	D009369			together with the recent identification of novel miRNA regulatory factors and pathways, highlights the importance of miRNA dysregulation in cancer.
tissue_expression_ns	hsa-mir-16	Neoplasms [unspecific]	26299954			C80.1	D009369			Genome-wide analysis of microRNA and mRNA expression signatures in cancer.
tissue_expression_ns	hsa-mir-17	Neoplasms [unspecific]	28222938			C80.1	D009369			The role of miR-17-92 cluster in the expression of tumor suppressor genes in unrestricted somatic stem cells.
tissue_expression_ns	hsa-mir-182	Neoplasms [unspecific]	23791657			C80.1	D009369			Meta-analysis of microRNA-183 family expression in human cancer studies comparing cancer tissues with noncancerous tissues.
tissue_expression_ns	hsa-mir-183	Neoplasms [unspecific]	24609385			C80.1	D009369			Together, our probabilistic approach of integrating expression and sequence scores establishes a functional link between the aberrant miRNA and mRNA expression, which was previously under-appreciated due to the methodological differences.
tissue_expression_ns	hsa-mir-183	Neoplasms [unspecific]	23791657			C80.1	D009369			Meta-analysis of microRNA-183 family expression in human cancer studies comparing cancer tissues with noncancerous tissues.
tissue_expression_ns	hsa-mir-18a	Neoplasms [unspecific]	28222938			C80.1	D009369			The role of miR-17-92 cluster in the expression of tumor suppressor genes in unrestricted somatic stem cells.
tissue_expression_ns	hsa-mir-191	Neoplasms [unspecific]	26299954			C80.1	D009369			Genome-wide analysis of microRNA and mRNA expression signatures in cancer.
tissue_expression_ns	hsa-mir-19a	Neoplasms [unspecific]	28222938			C80.1	D009369			The role of miR-17-92 cluster in the expression of tumor suppressor genes in unrestricted somatic stem cells.
tissue_expression_ns	hsa-mir-19b	Neoplasms [unspecific]	28222938			C80.1	D009369			The role of miR-17-92 cluster in the expression of tumor suppressor genes in unrestricted somatic stem cells.
tissue_expression_ns	hsa-mir-200a	Neoplasms [unspecific]	20498632			C80.1	D009369			miR-200a:altered microRNA signatures as potent markers for ATCs
tissue_expression_ns	hsa-mir-200b	Neoplasms [unspecific]	20498632			C80.1	D009369			miR-200b:altered microRNA signatures as potent markers for ATCs
tissue_expression_ns	hsa-mir-200c	Neoplasms [unspecific]	20498632			C80.1	D009369			miR-200c:altered microRNA signatures as potent markers for ATCs
tissue_expression_ns	hsa-mir-200c	Neoplasms [unspecific]	27623940			C80.1	D009369			Aberrant microRNA expression in tumor mycosis fungoides.
tissue_expression_ns	hsa-mir-20a	Neoplasms [unspecific]	28222938			C80.1	D009369			The role of miR-17-92 cluster in the expression of tumor suppressor genes in unrestricted somatic stem cells.
tissue_expression_ns	hsa-mir-21	Neoplasms [unspecific]	24974841			C80.1	D009369			Using microRNA expression profiles the authors were able to distinguish peritumoural tissues according to distance from the primary tumour site. Future application of the method may prove to be useful in early detection of the altered epigenetic regulation in tissue fields representing normal phenotype. This may be helpful in cancer risk assessment and prevention.
tissue_expression_ns	hsa-mir-21	Neoplasms [unspecific]	24609385			C80.1	D009369			Together, our probabilistic approach of integrating expression and sequence scores establishes a functional link between the aberrant miRNA and mRNA expression, which was previously under-appreciated due to the methodological differences.
tissue_expression_ns	hsa-mir-21	Neoplasms [unspecific]	20498632			C80.1	D009369			miR-21:altered microRNA signatures as potent markers for ATCs
tissue_expression_ns	hsa-mir-210	Neoplasms [unspecific]	25075017			C80.1	D009369			Prognostic microRNA expression signature from examination of colorectal primary and metastatic tumors.
tissue_expression_ns	hsa-mir-210	Neoplasms [unspecific]	27623940			C80.1	D009369			Aberrant microRNA expression in tumor mycosis fungoides.
tissue_expression_ns	hsa-mir-214	Neoplasms [unspecific]	28536479			C80.1	D009369			Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease.
tissue_expression_ns	hsa-mir-22	Neoplasms [unspecific]	26295583			C80.1	D009369			Genome Wide Expression Profiling of Cancer Cell Lines Cultured in Microgravity Reveals Significant Dysregulation of Cell Cycle and MicroRNA Gene Networks.
tissue_expression_ns	hsa-mir-221	Neoplasms [unspecific]	24974841			C80.1	D009369			Using microRNA expression profiles the authors were able to distinguish peritumoural tissues according to distance from the primary tumour site. Future application of the method may prove to be useful in early detection of the altered epigenetic regulation in tissue fields representing normal phenotype. This may be helpful in cancer risk assessment and prevention.
tissue_expression_ns	hsa-mir-221	Neoplasms [unspecific]	24609385			C80.1	D009369			Together, our probabilistic approach of integrating expression and sequence scores establishes a functional link between the aberrant miRNA and mRNA expression, which was previously under-appreciated due to the methodological differences.
tissue_expression_ns	hsa-mir-222	Neoplasms [unspecific]	24609385			C80.1	D009369			Together, our probabilistic approach of integrating expression and sequence scores establishes a functional link between the aberrant miRNA and mRNA expression, which was previously under-appreciated due to the methodological differences.
tissue_expression_ns	hsa-mir-29a	Neoplasms [unspecific]	27623940			C80.1	D009369			Aberrant microRNA expression in tumor mycosis fungoides.
tissue_expression_ns	hsa-mir-302c	Neoplasms [unspecific]	24515752			C80.1	D009369			Microvesicle-associated microRNA expression is altered upon particulate matter exposure in healthy workers and in A549 cells.
tissue_expression_ns	hsa-mir-30a	Neoplasms [unspecific]	20498632			C80.1	D009369			miR-30:altered microRNA signatures as potent markers for ATCs
tissue_expression_ns	hsa-mir-3177	Neoplasms [unspecific]	27623940			C80.1	D009369			Aberrant microRNA expression in tumor mycosis fungoides.
tissue_expression_ns	hsa-mir-330	Neoplasms [unspecific]	24278004			C80.1	D009369			MicroRNA-gene association as a prognostic biomarker in cancer exposes disease mechanisms.
tissue_expression_ns	hsa-mir-34	Neoplasms [unspecific]	25452192			C80.1	D009369			miR-34 family members could be expected to become potential diagnostic and prognostic biomarkers in some types of human cancers. Further well-designed and larger sample studies are surely warranted to identify the role of the miR-34 family in the occurrence and development of tumors.
tissue_expression_ns	hsa-mir-34a	Neoplasms [unspecific]	27623940			C80.1	D009369			Aberrant microRNA expression in tumor mycosis fungoides.
tissue_expression_ns	hsa-mir-373	Neoplasms [unspecific]	25990556			C80.1	D009369			Deregulation of miR-373 has been demonstrated in a number of cancers, whether it acts as an oncogene or a tumor suppressor, however, seems to be context dependent. In this review, we focus on the diverse functions of miR-373 and its implication in cancers.
tissue_expression_ns	hsa-mir-514b	Neoplasms [unspecific]	27623940			C80.1	D009369			Aberrant microRNA expression in tumor mycosis fungoides.
tissue_expression_ns	hsa-mir-638	Neoplasms [unspecific]	23936320			C80.1	D009369			Characterization of microRNA expression profiles and the discovery of novel microRNAs involved in cancer during human embryonic development.
tissue_expression_ns	hsa-mir-7	Neoplasms [unspecific]	26578390			C80.1	D009369			we found hsa-miR-194 and  hsa-miR-7 along with 7 transcription factors (TFs) such as SOX11, SMAD3 and SOX4  etc. could correctly differentiate SPN from PanNET
tissue_expression_ns	hsa-mir-720	Neoplasms [unspecific]	23936320			C80.1	D009369			Characterization of microRNA expression profiles and the discovery of novel microRNAs involved in cancer during human embryonic development.
tissue_expression_ns	hsa-mir-92a	Neoplasms [unspecific]	28222938			C80.1	D009369			The role of miR-17-92 cluster in the expression of tumor suppressor genes in unrestricted somatic stem cells.
tissue_expression_ns	hsa-mir-93	Neoplasms [unspecific]	26299954			C80.1	D009369			Genome-wide analysis of microRNA and mRNA expression signatures in cancer.
tissue_expression_ns	hsa-mir-96	Neoplasms [unspecific]	23791657			C80.1	D009369			Meta-analysis of microRNA-183 family expression in human cancer studies comparing cancer tissues with noncancerous tissues.
tissue_expression_ns	hsa-mir-147b	Neuroblastoma	23724168	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Numerous miRNAs were detected by microarrays to be regulated by the combined lithium and valproic acid treatment, and the following candidates were confirmed using real-time PCR: miR-34a, miR-147b, miR-182,miR-222, miR-495, and miR-690. 
tissue_expression_ns	hsa-mir-182	Neuroblastoma	23724168	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Numerous miRNAs were detected by microarrays to be regulated by the combined lithium and valproic acid treatment, and the following candidates were confirmed using real-time PCR: miR-34a, miR-147b, miR-182,miR-222, miR-495, and miR-690. 
tissue_expression_ns	hsa-mir-222	Neuroblastoma	23724168	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Numerous miRNAs were detected by microarrays to be regulated by the combined lithium and valproic acid treatment, and the following candidates were confirmed using real-time PCR: miR-34a, miR-147b, miR-182,miR-222, miR-495, and miR-690. 
tissue_expression_ns	hsa-mir-34a	Neuroblastoma	23724168	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Numerous miRNAs were detected by microarrays to be regulated by the combined lithium and valproic acid treatment, and the following candidates were confirmed using real-time PCR: miR-34a, miR-147b, miR-182,miR-222, miR-495, and miR-690. 
tissue_expression_ns	hsa-mir-34a	Neuroblastoma	25292042	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Hsa-miR-34a, for example, targets gene  MYC, which regulates hsa-miR-34a in turn.
tissue_expression_ns	hsa-mir-496	Neuroblastoma	23724168	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Numerous miRNAs were detected by microarrays to be regulated by the combined lithium and valproic acid treatment, and the following candidates were confirmed using real-time PCR: miR-34a, miR-147b, miR-182,miR-222, miR-495, and miR-690. 
tissue_expression_ns	hsa-mir-690	Neuroblastoma	23724168	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Numerous miRNAs were detected by microarrays to be regulated by the combined lithium and valproic acid treatment, and the following candidates were confirmed using real-time PCR: miR-34a, miR-147b, miR-182,miR-222, miR-495, and miR-690. 
tissue_expression_ns	hsa-mir-133a	Neuroendocrine Tumors	24535468	disease of cellular proliferation	DOID:169	C7A	D018358			Establishment of robust controls for the normalization of miRNA expression in neuroendocrine tumors of the ileum and pancreas.
tissue_expression_ns	hsa-mir-191	Neuroendocrine Tumors	24535468	disease of cellular proliferation	DOID:169	C7A	D018358			Establishment of robust controls for the normalization of miRNA expression in neuroendocrine tumors of the ileum and pancreas.
tissue_expression_ns	hsa-mir-93	Neuroendocrine Tumors	24535468	disease of cellular proliferation	DOID:169	C7A	D018358			Establishment of robust controls for the normalization of miRNA expression in neuroendocrine tumors of the ileum and pancreas.
tissue_expression_ns	hsa-mir-1909	Neuroepithelial Tumors	26698155				D018302			Our findings indicated that miR-3138 might act as a tumor suppressor gene when down-regulated and miR-1909* as a putative oncogenic molecule when up-regulated in pediatric DNETs compared to the control cohort. Subsequently, both miRNA signatures might serve as putative diagnostic biomarkers for pediatric DNETs.
tissue_expression_ns	hsa-mir-3138	Neuroepithelial Tumors	26698155				D018302			Our findings indicated that miR-3138 might act as a tumor suppressor gene when down-regulated and miR-1909* as a putative oncogenic molecule when up-regulated in pediatric DNETs compared to the control cohort. Subsequently, both miRNA signatures might serve as putative diagnostic biomarkers for pediatric DNETs.
tissue_expression_ns	hsa-let-7c	Nevus	21166724			I78.1	D009506	162900	HP:0003764	The microRNA molecular signature of atypic and common acquired melanocytic nevi: differential expression of miR-125b and let-7c.
tissue_expression_ns	hsa-mir-125b-1	Nevus	21166724			I78.1	D009506	162900	HP:0003764	The microRNA molecular signature of atypic and common acquired melanocytic nevi: differential expression of miR-125b and let-7c.
tissue_expression_ns	hsa-mir-125b-2	Nevus	21166724			I78.1	D009506	162900	HP:0003764	The microRNA molecular signature of atypic and common acquired melanocytic nevi: differential expression of miR-125b and let-7c.
tissue_expression_ns	hsa-let-7c	Non-Traumatic Osteonecrosis	25863178			M90.5	D010020			Our data also manifests that the signaling pathways regulated by these differentially expressed miRNAs might be important in the pathogenesis of non-traumatic ONFH.
tissue_expression_ns	hsa-let-7i	Non-Traumatic Osteonecrosis	25863178			M90.5	D010020			Our data also manifests that the signaling pathways regulated by these differentially expressed miRNAs might be important in the pathogenesis of non-traumatic ONFH.
tissue_expression_ns	hsa-mir-146b	Non-Traumatic Osteonecrosis	25863178			M90.5	D010020			Our data also manifests that the signaling pathways regulated by these differentially expressed miRNAs might be important in the pathogenesis of non-traumatic ONFH.
tissue_expression_ns	hsa-mir-320e	Non-Traumatic Osteonecrosis	25863178			M90.5	D010020			Our data also manifests that the signaling pathways regulated by these differentially expressed miRNAs might be important in the pathogenesis of non-traumatic ONFH.
tissue_expression_ns	hsa-mir-335	Non-Traumatic Osteonecrosis	25863178			M90.5	D010020			Our data also manifests that the signaling pathways regulated by these differentially expressed miRNAs might be important in the pathogenesis of non-traumatic ONFH.
tissue_expression_ns	hsa-let-7f	Obesity	27049726	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Our study shows that the first evidence of hsa-let-7 family, hsa-miR-15a-5p, hsa-miR-27a-3p, hsa-miR-106b-5p, hsa-miR-148a-3p and hsa-miR-26b-5p got a great weight in adipogenesis
tissue_expression_ns	hsa-mir-10b	Obesity	27682205	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Impact of endurance exercise training on adipocyte microRNA expression in overweight men.
tissue_expression_ns	hsa-mir-122	Obesity	25769350	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Deregulation of miR-33 and miR-122, as major regulators of lipid metabolism in liver, has been related to obesity and metabolic syndrome.
tissue_expression_ns	hsa-mir-125a	Obesity	24675842	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Adaptive expression of microRNA-125a in adipose tissue in response to obesity in mice and men.
tissue_expression_ns	hsa-mir-200a	Obesity	24758184	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Taken together, our data indicate that the dysregulated expression of miRNAs occurs in distinct cell types and is likely to affect cell-specific function(s) of obese WAT.
tissue_expression_ns	hsa-mir-200b	Obesity	24758184	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Taken together, our data indicate that the dysregulated expression of miRNAs occurs in distinct cell types and is likely to affect cell-specific function(s) of obese WAT.
tissue_expression_ns	hsa-mir-204	Obesity	27682205	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Impact of endurance exercise training on adipocyte microRNA expression in overweight men.
tissue_expression_ns	hsa-mir-219	Obesity	23817051	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	the miRNA profile is altered in amnion during obesity and hypothesize that this could affect pathways important for placental growth and function, thereby contributing to an increase in the newborn's risk of future metabolic diseases.
tissue_expression_ns	hsa-mir-335	Obesity	24758184	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Taken together, our data indicate that the dysregulated expression of miRNAs occurs in distinct cell types and is likely to affect cell-specific function(s) of obese WAT.
tissue_expression_ns	hsa-mir-342	Obesity	24758184	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Taken together, our data indicate that the dysregulated expression of miRNAs occurs in distinct cell types and is likely to affect cell-specific function(s) of obese WAT.
tissue_expression_ns	hsa-mir-3613	Obesity	27682205	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Impact of endurance exercise training on adipocyte microRNA expression in overweight men.
tissue_expression_ns	hsa-mir-370	Obesity	28386478	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Changes in the MicroRNA Profile Observed in the Subcutaneous Adipose Tissue of Obese Patients after Laparoscopic Adjustable Gastric Banding.
tissue_expression_ns	hsa-mir-422b	Obesity	23817051	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	the miRNA profile is altered in amnion during obesity and hypothesize that this could affect pathways important for placental growth and function, thereby contributing to an increase in the newborn's risk of future metabolic diseases.
tissue_expression_ns	hsa-mir-4532	Obesity	27682205	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Impact of endurance exercise training on adipocyte microRNA expression in overweight men.
tissue_expression_ns	hsa-mir-523	Obesity	23817051	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	the miRNA profile is altered in amnion during obesity and hypothesize that this could affect pathways important for placental growth and function, thereby contributing to an increase in the newborn's risk of future metabolic diseases.
tissue_expression_ns	hsa-mir-575	Obesity	23817051	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	the miRNA profile is altered in amnion during obesity and hypothesize that this could affect pathways important for placental growth and function, thereby contributing to an increase in the newborn's risk of future metabolic diseases.
tissue_expression_ns	hsa-mir-579	Obesity	23817051	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	the miRNA profile is altered in amnion during obesity and hypothesize that this could affect pathways important for placental growth and function, thereby contributing to an increase in the newborn's risk of future metabolic diseases.
tissue_expression_ns	hsa-mir-618	Obesity	23817051	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	the miRNA profile is altered in amnion during obesity and hypothesize that this could affect pathways important for placental growth and function, thereby contributing to an increase in the newborn's risk of future metabolic diseases.
tissue_expression_ns	hsa-mir-659	Obesity	23817051	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	the miRNA profile is altered in amnion during obesity and hypothesize that this could affect pathways important for placental growth and function, thereby contributing to an increase in the newborn's risk of future metabolic diseases.
tissue_expression_ns	hsa-mir-181b	Oral Leukoplakia	24020903	gastrointestinal system disease	DOID:9655	K13.21	D007972		HP:0002745	some cytological and histopathological parameters used to grade dysplasia are associated with altered  miRNA expression.
tissue_expression_ns	hsa-mir-21	Oral Leukoplakia	24020903	gastrointestinal system disease	DOID:9655	K13.21	D007972		HP:0002745	some cytological and histopathological parameters used to grade dysplasia are associated with altered  miRNA expression.
tissue_expression_ns	hsa-mir-345	Oral Leukoplakia	24020903	gastrointestinal system disease	DOID:9655	K13.21	D007972		HP:0002745	some cytological and histopathological parameters used to grade dysplasia are associated with altered  miRNA expression.
tissue_expression_ns	hsa-mir-125b	Oral Neoplasms	27208839			C06.9	D009062		HP:0100649	Differential expression of miR-21, miR-100, miR-125b and miR-375 was validated in oral cytology training sample set.
tissue_expression_ns	hsa-mir-140	Osteoarthritis	25785087	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	We verified that miR-140 and miR-455 were associated with cartilage development
tissue_expression_ns	hsa-mir-140	Osteoarthritis	28065216	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	Expression of miRNA-140 in Chondrocytes and Synovial Fluid of Knee Joints in Patients with Osteoarthritis.
tissue_expression_ns	hsa-mir-140	Osteoarthritis	28085114	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway.
tissue_expression_ns	hsa-mir-146a	Osteoarthritis	28085114	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway.
tissue_expression_ns	hsa-mir-146b	Osteoarthritis	28085114	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway.
tissue_expression_ns	hsa-mir-27a	Osteoarthritis	28085114	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway.
tissue_expression_ns	hsa-mir-27b	Osteoarthritis	28085114	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway.
tissue_expression_ns	hsa-mir-365	Osteoarthritis	28085114	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway.
tissue_expression_ns	hsa-mir-9	Osteoarthritis	25785087	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	miR-9 and miR-98 were involved in the endochondral ossification, suggesting they may be also the key regulators in the process of endochondral ossification.
tissue_expression_ns	hsa-mir-98	Osteoarthritis	25785087	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	miR-9 and miR-98 were involved in the endochondral ossification, suggesting they may be also the key regulators in the process of endochondral ossification.
tissue_expression_ns	hsa-mir-106b	Osteosarcoma	28272712	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	The expression and function of miRNA-106 in pediatric osteosarcoma.
tissue_expression_ns	hsa-mir-126	Osteosarcoma	25510179	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	expression of miR-126 increased the sensitivity of osteosarcoma cells to EGCG through induction of apoptosis.
tissue_expression_ns	hsa-mir-126	Osteosarcoma	26194657	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	Tissue microRNA-126 expression level predicts outcome in human osteosarcoma.
tissue_expression_ns	hsa-mir-135b	Osteosarcoma	21789031	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	deregulated
tissue_expression_ns	hsa-mir-148a	Osteosarcoma	27041566	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	we show that miR-148a-3p and miR-155-5p are species-conserved deregulated miRNA in OS
tissue_expression_ns	hsa-mir-150	Osteosarcoma	21789031	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	deregulated
tissue_expression_ns	hsa-mir-155	Osteosarcoma	27041566	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	we show that miR-148a-3p and miR-155-5p are species-conserved deregulated miRNA in OS
tissue_expression_ns	hsa-mir-19a	Osteosarcoma	28214202	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	Elevated expression of microRNA-19a predicts a poor prognosis in patients with osteosarcoma.
tissue_expression_ns	hsa-mir-23a	Osteosarcoma	25322765	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	We identified miR-23a as a tumor suppressor in osteosarcoma. Our data clarify the mechanism of osteosarcoma progression and demonstrated the potential  for exploiting miR-23a as a diagnostic marker for osteosarcoma.
tissue_expression_ns	hsa-mir-542	Osteosarcoma	21789031	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	miR-542-5p: deregulated
tissue_expression_ns	hsa-mir-652	Osteosarcoma	21789031	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	deregulated
tissue_expression_ns	hsa-let-7i	Ovarian Disease	25451316	endocrine system disease	DOID:1100	E28.9	D010049			let-7i-5p, miR-122,miR-152-5p and miR-25-3p could act as diagnostic biomarkers in ovarian cancer.
tissue_expression_ns	hsa-mir-122	Ovarian Disease	25451316	endocrine system disease	DOID:1100	E28.9	D010049			let-7i-5p, miR-122,miR-152-5p and miR-25-3p could act as diagnostic biomarkers in ovarian cancer.
tissue_expression_ns	hsa-mir-152	Ovarian Disease	25451316	endocrine system disease	DOID:1100	E28.9	D010049			let-7i-5p, miR-122,miR-152-5p and miR-25-3p could act as diagnostic biomarkers in ovarian cancer.
tissue_expression_ns	hsa-mir-15b	Ovarian Disease	29377183	endocrine system disease	DOID:1100	E28.9	D010049			miR-379, miR-15b, miR-691, miR-872 and miR-1897-5p are potentially useful markers of ovarian toxicity and dysfunction
tissue_expression_ns	hsa-mir-1897	Ovarian Disease	29377183	endocrine system disease	DOID:1100	E28.9	D010049			miR-379, miR-15b, miR-691, miR-872 and miR-1897-5p are potentially useful markers of ovarian toxicity and dysfunction
tissue_expression_ns	hsa-mir-25	Ovarian Disease	25451316	endocrine system disease	DOID:1100	E28.9	D010049			let-7i-5p, miR-122,miR-152-5p and miR-25-3p could act as diagnostic biomarkers in ovarian cancer.
tissue_expression_ns	hsa-mir-379	Ovarian Disease	29377183	endocrine system disease	DOID:1100	E28.9	D010049			miR-379, miR-15b, miR-691, miR-872 and miR-1897-5p are potentially useful markers of ovarian toxicity and dysfunction
tissue_expression_ns	hsa-mir-691	Ovarian Disease	29377183	endocrine system disease	DOID:1100	E28.9	D010049			miR-379, miR-15b, miR-691, miR-872 and miR-1897-5p are potentially useful markers of ovarian toxicity and dysfunction
tissue_expression_ns	hsa-mir-872	Ovarian Disease	29377183	endocrine system disease	DOID:1100	E28.9	D010049			miR-379, miR-15b, miR-691, miR-872 and miR-1897-5p are potentially useful markers of ovarian toxicity and dysfunction
tissue_expression_ns	hsa-let-7	Ovarian Neoplasms	18199536	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Here, we show that several miRNAs are altered in human ovarian cancer, with the most significantly deregulated miRNAs being miR-214, miR-199a*, miR-200a, miR-100, miR-125b, and let-7 cluster.
tissue_expression_ns	hsa-let-7a	Ovarian Neoplasms	28423547	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Genomic imbalances are involved in miR-30c and let-7a deregulation in ovarian tumors: implications for HMGA2 expression.
tissue_expression_ns	hsa-let-7b	Ovarian Neoplasms	29385306	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	RT-PCR revealed a significantly increased expression of ovarian miRNAs (let-7b, miR-17-5p miR-181a, and miR-151), which inhibit follicular granulosa cell proliferation
tissue_expression_ns	hsa-mir-100	Ovarian Neoplasms	18199536	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Here, we show that several miRNAs are altered in human ovarian cancer, with the most significantly deregulated miRNAs being miR-214, miR-199a*, miR-200a, miR-100, miR-125b, and let-7 cluster.
tissue_expression_ns	hsa-mir-106a	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-106b	Ovarian Neoplasms	24805828	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The results obtained by miRNA microarrays of differential expression with hsa-miR-106b-3p, hsa-miR-152, hsa-miR-200a-3p, hsa-miR-381, and hsa-miR-429 were confirmed by real-time PCR.
tissue_expression_ns	hsa-mir-107	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-125b	Ovarian Neoplasms	18199536	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Here, we show that several miRNAs are altered in human ovarian cancer, with the most significantly deregulated miRNAs being miR-214, miR-199a*, miR-200a, miR-100, miR-125b, and let-7 cluster.
tissue_expression_ns	hsa-mir-125b	Ovarian Neoplasms	20658525	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Our results suggest that aberrantly expressed miR-125b may contribute to OC development.
tissue_expression_ns	hsa-mir-141	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-142	Ovarian Neoplasms	18182067	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We selected and validated the expression of miR-20a, miR-21, miR-26a, miR-18a, miR-206, miR-181a and miR-142-5p and found their differential expression in tissue and cell-specific manners (P<0.05).
tissue_expression_ns	hsa-mir-151	Ovarian Neoplasms	29385306	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	RT-PCR revealed a significantly increased expression of ovarian miRNAs (let-7b, miR-17-5p miR-181a, and miR-151), which inhibit follicular granulosa cell proliferation
tissue_expression_ns	hsa-mir-153	Ovarian Neoplasms	21083603	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours.
tissue_expression_ns	hsa-mir-17	Ovarian Neoplasms	29385306	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	RT-PCR revealed a significantly increased expression of ovarian miRNAs (let-7b, miR-17-5p miR-181a, and miR-151), which inhibit follicular granulosa cell proliferation
tissue_expression_ns	hsa-mir-181a	Ovarian Neoplasms	29385306	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	RT-PCR revealed a significantly increased expression of ovarian miRNAs (let-7b, miR-17-5p miR-181a, and miR-151), which inhibit follicular granulosa cell proliferation
tissue_expression_ns	hsa-mir-181a	Ovarian Neoplasms	18182067	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We selected and validated the expression of miR-20a, miR-21, miR-26a, miR-18a, miR-206, miR-181a and miR-142-5p and found their differential expression in tissue and cell-specific manners (P<0.05).
tissue_expression_ns	hsa-mir-181d	Ovarian Neoplasms	22925189	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues.
tissue_expression_ns	hsa-mir-187	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-18a	Ovarian Neoplasms	18182067	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We selected and validated the expression of miR-20a, miR-21, miR-26a, miR-18a, miR-206, miR-181a and miR-142-5p and found their differential expression in tissue and cell-specific manners (P<0.05).
tissue_expression_ns	hsa-mir-195	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-199a	Ovarian Neoplasms	18199536	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Here, we show that several miRNAs are altered in human ovarian cancer, with the most significantly deregulated miRNAs being miR-214, miR-199a*, miR-200a, miR-100, miR-125b, and let-7 cluster.
tissue_expression_ns	hsa-mir-199a	Ovarian Neoplasms	21882851	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Many aberrantly expressed miRNAs were related to various cancers (e.g., miR-125b, hepatocellular carcinoma; miR-21, leukemia; miR-16, chronic lymphocytic leukemia;miR-192, pituitary adenomas; miR-199a-3p, ovarian cancer; miR-34a, pancreatic cancer).
tissue_expression_ns	hsa-mir-200a	Ovarian Neoplasms	18199536	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Here, we show that several miRNAs are altered in human ovarian cancer, with the most significantly deregulated miRNAs being miR-214, miR-199a*, miR-200a, miR-100, miR-125b, and let-7 cluster.
tissue_expression_ns	hsa-mir-200c	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-206	Ovarian Neoplasms	18182067	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We selected and validated the expression of miR-20a, miR-21, miR-26a, miR-18a, miR-206, miR-181a and miR-142-5p and found their differential expression in tissue and cell-specific manners (P<0.05).
tissue_expression_ns	hsa-mir-20a	Ovarian Neoplasms	18182067	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We selected and validated the expression of miR-20a, miR-21, miR-26a, miR-18a, miR-206, miR-181a and miR-142-5p and found their differential expression in tissue and cell-specific manners (P<0.05).
tissue_expression_ns	hsa-mir-21	Ovarian Neoplasms	18182067	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We selected and validated the expression of miR-20a, miR-21, miR-26a, miR-18a, miR-206, miR-181a and miR-142-5p and found their differential expression in tissue and cell-specific manners (P<0.05).
tissue_expression_ns	hsa-mir-221	Ovarian Neoplasms	23569131	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Prognostic significance of serum microRNA-221 expression in human epithelial ovarian cancer
tissue_expression_ns	hsa-mir-26a	Ovarian Neoplasms	18182067	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We selected and validated the expression of miR-20a, miR-21, miR-26a, miR-18a, miR-206, miR-181a and miR-142-5p and found their differential expression in tissue and cell-specific manners (P<0.05).
tissue_expression_ns	hsa-mir-302b	Ovarian Neoplasms	23484053	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	hsa-miR-302b expression was significantly associated with time to relapse or overall survival in two data sets of platinum-treated ovarian cancer patients.
tissue_expression_ns	hsa-mir-30a	Ovarian Neoplasms	22925189	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues.
tissue_expression_ns	hsa-mir-30c	Ovarian Neoplasms	28423547	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Genomic imbalances are involved in miR-30c and let-7a deregulation in ovarian tumors: implications for HMGA2 expression.
tissue_expression_ns	hsa-mir-30c-1	Ovarian Neoplasms	22925189	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues.
tissue_expression_ns	hsa-mir-30c-2	Ovarian Neoplasms	22925189	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues.
tissue_expression_ns	hsa-mir-30d	Ovarian Neoplasms	22925189	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues.
tissue_expression_ns	hsa-mir-30e	Ovarian Neoplasms	22925189	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues.
tissue_expression_ns	hsa-mir-34c	Ovarian Neoplasms	19798417	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	High grade serous carcinomas as a group exhibit significant miRNA dysregulation in comparison to tubal epithelium and the levels of miR-34c and miR-422b appear to be prognostically important.
tissue_expression_ns	hsa-mir-370	Ovarian Neoplasms	22925189	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues.
tissue_expression_ns	hsa-mir-378	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-409	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-411	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-422b	Ovarian Neoplasms	19798417	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	High grade serous carcinomas as a group exhibit significant miRNA dysregulation in comparison to tubal epithelium and the levels of miR-34c and miR-422b appear to be prognostically important.
tissue_expression_ns	hsa-mir-432	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-485	Ovarian Neoplasms	21083603	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours.
tissue_expression_ns	hsa-mir-494	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-497	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-519a	Ovarian Neoplasms	21083603	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours.
tissue_expression_ns	hsa-mir-532	Ovarian Neoplasms	22925189	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues.
tissue_expression_ns	hsa-mir-622	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-647	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-663	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-96	Ovarian Neoplasms	24591819	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells.
tissue_expression_ns	hsa-mir-1244	Pallister-Killian Syndrome	24981202				C538105	601803		12p microRNA expression in fibroblast cell lines from probands with Pallister-Killian syndrome.
tissue_expression_ns	hsa-mir-145	Pancreatic Adenocarcinoma	28903323	disease of cellular proliferation	DOID:4074	C25.3				The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma.
tissue_expression_ns	hsa-mir-205	Pancreatic Adenocarcinoma	28903323	disease of cellular proliferation	DOID:4074	C25.3				The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma.
tissue_expression_ns	hsa-mir-21	Pancreatic Adenocarcinoma	29069873	disease of cellular proliferation	DOID:4074	C25.3				These molecules are often aberrantly expressed and exhibit oncogenic and/or tumor suppressor functions in PDAC
tissue_expression_ns	hsa-mir-100	Pancreatic Neoplasms	21785383	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Differentially expressed miRNAs including miR-99a, miR-100, miR-125b, miR-192, and miR-429 were detected in pancreatic cancer stem cells.
tissue_expression_ns	hsa-mir-103	Pancreatic Neoplasms	16966691	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		the expression of miR-103 and miR-107, associated with lack of expression of miR-155, discriminates tumors from normal
tissue_expression_ns	hsa-mir-107	Pancreatic Neoplasms	16966691	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		the expression of miR-103 and miR-107, associated with lack of expression of miR-155, discriminates tumors from normal
tissue_expression_ns	hsa-mir-1246	Pancreatic Neoplasms	25117811	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-1246 expression was associated with chemoresistance and CSC-like properties via CCNG2, and could predict worse prognosis in pancreatic cancer patients.
tissue_expression_ns	hsa-mir-1246	Pancreatic Neoplasms	25388097	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		the concomitant evaluation of PaCIC and PaCa-related miRNA marker panels awaits retrospective analyses of larger cohorts, as it should allow for a highly sensitive, minimally-invasive PaCa diagnostics.
tissue_expression_ns	hsa-mir-125b-1	Pancreatic Neoplasms	21785383	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Differentially expressed miRNAs including miR-99a, miR-100, miR-125b, miR-192, and miR-429 were detected in pancreatic cancer stem cells.
tissue_expression_ns	hsa-mir-125b-1	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-125b-2	Pancreatic Neoplasms	21785383	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Differentially expressed miRNAs including miR-99a, miR-100, miR-125b, miR-192, and miR-429 were detected in pancreatic cancer stem cells.
tissue_expression_ns	hsa-mir-125b-2	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-130b	Pancreatic Neoplasms	24662333	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We developed and validated a 5-miRNA classifier that can accurately predict which preoperative pancreatic EUS-FNA specimens contain PDAC. This test might aid in the diagnosis of pancreatic cancer by reducing the number of FNAs without a definitive adenocarcinoma diagnosis, thereby reducing the number of repeat EUS-FNA procedures.
tissue_expression_ns	hsa-mir-135b	Pancreatic Neoplasms	24662333	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We developed and validated a 5-miRNA classifier that can accurately predict which preoperative pancreatic EUS-FNA specimens contain PDAC. This test might aid in the diagnosis of pancreatic cancer by reducing the number of FNAs without a definitive adenocarcinoma diagnosis, thereby reducing the number of repeat EUS-FNA procedures.
tissue_expression_ns	hsa-mir-143	Pancreatic Neoplasms	22836856	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Changes in miR-143 and miR-21 Expression are correlated with Clinicopathology in Pancreatic Cancers.
tissue_expression_ns	hsa-mir-146a	Pancreatic Neoplasms	24839931	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Deregulation of miR-146a expression in a mouse model of pancreatic cancer affecting EGFR signaling.
tissue_expression_ns	hsa-mir-146a	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-148a	Pancreatic Neoplasms	24662333	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We developed and validated a 5-miRNA classifier that can accurately predict which preoperative pancreatic EUS-FNA specimens contain PDAC. This test might aid in the diagnosis of pancreatic cancer by reducing the number of FNAs without a definitive adenocarcinoma diagnosis, thereby reducing the number of repeat EUS-FNA procedures.
tissue_expression_ns	hsa-mir-155	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-155	Pancreatic Neoplasms	26499892	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We found miR-21, miR-155 or miR-217 expression values in tumors may differ up to several times
tissue_expression_ns	hsa-mir-155	Pancreatic Neoplasms	16966691	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		the expression of miR-103 and miR-107, associated with lack of expression of miR-155, discriminates tumors from normal
tissue_expression_ns	hsa-mir-155	Pancreatic Neoplasms	17149698	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		One hundred microRNA precursors were aberrantly expressed in pancreatic cancer or desmoplasia (p < 0.01), including microRNAs previously reported as differentially expressed in other human cancers (miR-155, miR-21, miR-221 and miR-222) as well as those not previously reported in cancer (miR-376a and miR-301).
tissue_expression_ns	hsa-mir-15a	Pancreatic Neoplasms	21106054	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Dysregulation of miR-15a and miR-214 in human pancreatic cancer.
tissue_expression_ns	hsa-mir-182	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-183	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-183*:altered expression
tissue_expression_ns	hsa-mir-192	Pancreatic Neoplasms	21785383	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Differentially expressed miRNAs including miR-99a, miR-100, miR-125b, miR-192, and miR-429 were detected in pancreatic cancer stem cells.
tissue_expression_ns	hsa-mir-196	Pancreatic Neoplasms	24662333	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We developed and validated a 5-miRNA classifier that can accurately predict which preoperative pancreatic EUS-FNA specimens contain PDAC. This test might aid in the diagnosis of pancreatic cancer by reducing the number of FNAs without a definitive adenocarcinoma diagnosis, thereby reducing the number of repeat EUS-FNA procedures.
tissue_expression_ns	hsa-mir-196a	Pancreatic Neoplasms	24048456	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Our results provide experimental evidence to support aberrant expression of miR-196a is associated with abnormal apoptosis, invasion, and proliferation of pancreatic cancer cells.
tissue_expression_ns	hsa-mir-196a	Pancreatic Neoplasms	26499892	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Moreover, different internal controls can produce controversial results for miR-96, miR-148a or miR-196a quantification.
tissue_expression_ns	hsa-mir-196a-1	Pancreatic Neoplasms	18719196	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-196a: biomarkers improved the ability to distinguish between healthy tissue, PDAC, and chronic pancreatitis
tissue_expression_ns	hsa-mir-196a-1	Pancreatic Neoplasms	21463235	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-196a-2	Pancreatic Neoplasms	18719196	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-196a: biomarkers improved the ability to distinguish between healthy tissue, PDAC, and chronic pancreatitis
tissue_expression_ns	hsa-mir-196a-2	Pancreatic Neoplasms	21463235	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-196b	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-200a	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-200b	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-200b	Pancreatic Neoplasms	28548126	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		MicroRNA dysregulation in the tumor microenvironment influences the phenotype of pancreatic cancer.
tissue_expression_ns	hsa-mir-200c	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-200c	Pancreatic Neoplasms	28548126	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		MicroRNA dysregulation in the tumor microenvironment influences the phenotype of pancreatic cancer.
tissue_expression_ns	hsa-mir-203	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-21	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-21	Pancreatic Neoplasms	22836856	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Changes in miR-143 and miR-21 Expression are correlated with Clinicopathology in Pancreatic Cancers.
tissue_expression_ns	hsa-mir-21	Pancreatic Neoplasms	28186267	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We also examined miRNA expression [microRNA-21 (miR-21) and microRNA-31 (miR-31)] and epigenetic alterations, including CpG island methylator phenotype (CIMP), potentially associated with the identified miRNAs
tissue_expression_ns	hsa-mir-21	Pancreatic Neoplasms	28548126	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		MicroRNA dysregulation in the tumor microenvironment influences the phenotype of pancreatic cancer.
tissue_expression_ns	hsa-mir-21	Pancreatic Neoplasms	17149698	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		One hundred microRNA precursors were aberrantly expressed in pancreatic cancer or desmoplasia (p < 0.01), including microRNAs previously reported as differentially expressed in other human cancers (miR-155, miR-21, miR-221 and miR-222) as well as those not previously reported in cancer (miR-376a and miR-301).
tissue_expression_ns	hsa-mir-210	Pancreatic Neoplasms	28548126	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		MicroRNA dysregulation in the tumor microenvironment influences the phenotype of pancreatic cancer.
tissue_expression_ns	hsa-mir-214	Pancreatic Neoplasms	21106054	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Dysregulation of miR-15a and miR-214 in human pancreatic cancer.
tissue_expression_ns	hsa-mir-216a	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-216b	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-217	Pancreatic Neoplasms	18719196	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-217: biomarkers improved the ability to distinguish between healthy tissue, PDAC, and chronic pancreatitis
tissue_expression_ns	hsa-mir-217	Pancreatic Neoplasms	21463235	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-217	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-221	Pancreatic Neoplasms	17149698	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		One hundred microRNA precursors were aberrantly expressed in pancreatic cancer or desmoplasia (p < 0.01), including microRNAs previously reported as differentially expressed in other human cancers (miR-155, miR-21, miR-221 and miR-222) as well as those not previously reported in cancer (miR-376a and miR-301).
tissue_expression_ns	hsa-mir-222	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-222	Pancreatic Neoplasms	17149698	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		One hundred microRNA precursors were aberrantly expressed in pancreatic cancer or desmoplasia (p < 0.01), including microRNAs previously reported as differentially expressed in other human cancers (miR-155, miR-21, miR-221 and miR-222) as well as those not previously reported in cancer (miR-376a and miR-301).
tissue_expression_ns	hsa-mir-24	Pancreatic Neoplasms	24662333	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We developed and validated a 5-miRNA classifier that can accurately predict which preoperative pancreatic EUS-FNA specimens contain PDAC. This test might aid in the diagnosis of pancreatic cancer by reducing the number of FNAs without a definitive adenocarcinoma diagnosis, thereby reducing the number of repeat EUS-FNA procedures.
tissue_expression_ns	hsa-mir-296	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-296-5p:altered expression
tissue_expression_ns	hsa-mir-301	Pancreatic Neoplasms	17149698	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		One hundred microRNA precursors were aberrantly expressed in pancreatic cancer or desmoplasia (p < 0.01), including microRNAs previously reported as differentially expressed in other human cancers (miR-155, miR-21, miR-221 and miR-222) as well as those not previously reported in cancer (miR-376a and miR-301).
tissue_expression_ns	hsa-mir-31	Pancreatic Neoplasms	28186267	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We also examined miRNA expression [microRNA-21 (miR-21) and microRNA-31 (miR-31)] and epigenetic alterations, including CpG island methylator phenotype (CIMP), potentially associated with the identified miRNAs
tissue_expression_ns	hsa-mir-338	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-338-3p;altered expression
tissue_expression_ns	hsa-mir-34a	Pancreatic Neoplasms	21882851	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Many aberrantly expressed miRNAs were related to various cancers (e.g., miR-125b, hepatocellular carcinoma; miR-21, leukemia; miR-16, chronic lymphocytic leukemia;miR-192, pituitary adenomas; miR-199a-3p, ovarian cancer; miR-34a, pancreatic cancer).
tissue_expression_ns	hsa-mir-376a	Pancreatic Neoplasms	17149698	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		One hundred microRNA precursors were aberrantly expressed in pancreatic cancer or desmoplasia (p < 0.01), including microRNAs previously reported as differentially expressed in other human cancers (miR-155, miR-21, miR-221 and miR-222) as well as those not previously reported in cancer (miR-376a and miR-301).
tissue_expression_ns	hsa-mir-3976	Pancreatic Neoplasms	25388097	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		the concomitant evaluation of PaCIC and PaCa-related miRNA marker panels awaits retrospective analyses of larger cohorts, as it should allow for a highly sensitive, minimally-invasive PaCa diagnostics.
tissue_expression_ns	hsa-mir-429	Pancreatic Neoplasms	21785383	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Differentially expressed miRNAs including miR-99a, miR-100, miR-125b, miR-192, and miR-429 were detected in pancreatic cancer stem cells.
tissue_expression_ns	hsa-mir-4306	Pancreatic Neoplasms	25388097	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		the concomitant evaluation of PaCIC and PaCa-related miRNA marker panels awaits retrospective analyses of larger cohorts, as it should allow for a highly sensitive, minimally-invasive PaCa diagnostics.
tissue_expression_ns	hsa-mir-4644	Pancreatic Neoplasms	25388097	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		the concomitant evaluation of PaCIC and PaCa-related miRNA marker panels awaits retrospective analyses of larger cohorts, as it should allow for a highly sensitive, minimally-invasive PaCa diagnostics.
tissue_expression_ns	hsa-mir-486	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-486-3p:altered expression
tissue_expression_ns	hsa-mir-494	Pancreatic Neoplasms	26782462	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Correlation of miR-494 expression with tumor progression and patient survival in pancreatic cancer.
tissue_expression_ns	hsa-mir-603	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-625	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-625*:altered expression
tissue_expression_ns	hsa-mir-708	Pancreatic Neoplasms	22114139	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		altered expression
tissue_expression_ns	hsa-mir-99a	Pancreatic Neoplasms	21785383	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Differentially expressed miRNAs including miR-99a, miR-100, miR-125b, miR-192, and miR-429 were detected in pancreatic cancer stem cells.
tissue_expression_ns	hsa-mir-126	Parathyroid Carcinoma	29453660	endocrine system disease	DOID:1540	C75.0	D010282	608266	HP:0006780	miR-139, miR-222, miR-30b, miR-517c, and miR-126* were differentially expressed between PCa and PAd.
tissue_expression_ns	hsa-mir-139	Parathyroid Carcinoma	29453660	endocrine system disease	DOID:1540	C75.0	D010282	608266	HP:0006780	The combined analysis of miR-139 and miR-30b may be used as a potential diagnostic strategy for distinguishing Pca from PAd
tissue_expression_ns	hsa-mir-222	Parathyroid Carcinoma	29453660	endocrine system disease	DOID:1540	C75.0	D010282	608266	HP:0006780	miR-139, miR-222, miR-30b, miR-517c, and miR-126* were differentially expressed between PCa and PAd.
tissue_expression_ns	hsa-mir-30b	Parathyroid Carcinoma	29453660	endocrine system disease	DOID:1540	C75.0	D010282	608266	HP:0006780	The combined analysis of miR-139 and miR-31b may be used as a potential diagnostic strategy for distinguishing Pca from PAd
tissue_expression_ns	hsa-mir-517c	Parathyroid Carcinoma	29453660	endocrine system disease	DOID:1540	C75.0	D010282	608266	HP:0006780	miR-139, miR-222, miR-30b, miR-517c, and miR-126* were differentially expressed between PCa and PAd.
tissue_expression_ns	hsa-let-7g	Parkinson Disease	26497684	nervous system disease	DOID:14330	G20	D010300	PS168600		Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease.
tissue_expression_ns	hsa-mir-10a	Parkinson Disease	26497684	nervous system disease	DOID:14330	G20	D010300	PS168600		Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease.
tissue_expression_ns	hsa-mir-153	Parkinson Disease	26497684	nervous system disease	DOID:14330	G20	D010300	PS168600		Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease.
tissue_expression_ns	hsa-mir-16	Parkinson Disease	24427314	nervous system disease	DOID:14330	G20	D010300	PS168600		We identified a total of 761 genes and 24 miRNAs that were misregulated in the absence of LRRK2 when a false discovery rate of 0.2 was applied. Notably, most changes in gene expression were modest (i.e., <2 fold). By real-time quantitative RT-PCR, we confirmed the variations of selected genes (e.g., adra2, syt2, opalin) and miRNAs (e.g., miR-16, miR-25).
tissue_expression_ns	hsa-mir-19b	Parkinson Disease	25675938	nervous system disease	DOID:14330	G20	D010300	PS168600		Our findings indicate that dysregulation of the microRNA miR-19b occurs in the prodromal stage of synucleinopathies.
tissue_expression_ns	hsa-mir-29a	Parkinson Disease	25675938	nervous system disease	DOID:14330	G20	D010300	PS168600		Our findings indicate that dysregulation of the microRNA miR-19b occurs in the prodromal stage of synucleinopathies.
tissue_expression_ns	hsa-mir-29b	Parkinson Disease	28540642	nervous system disease	DOID:14330	G20	D010300	PS168600		Plasma and White Blood Cells Show Different miRNA Expression Profiles in Parkinson's Disease.
tissue_expression_ns	hsa-mir-29c	Parkinson Disease	25675938	nervous system disease	DOID:14330	G20	D010300	PS168600		Our findings indicate that dysregulation of the microRNA miR-19b occurs in the prodromal stage of synucleinopathies.
tissue_expression_ns	hsa-mir-30a	Parkinson Disease	28540642	nervous system disease	DOID:14330	G20	D010300	PS168600		Plasma and White Blood Cells Show Different miRNA Expression Profiles in Parkinson's Disease.
tissue_expression_ns	hsa-mir-409	Parkinson Disease	26497684	nervous system disease	DOID:14330	G20	D010300	PS168600		Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease.
tissue_expression_ns	hsa-mir-128	Pediatric Ependymoma	29704232	disease of cellular proliferation	DOID:5509					miR-543, miR-495-3p, miR-299-3p, miR-139-5p and miR-128-3p were identified to have CD44 positively co-regulated potential target oncogenes
tissue_expression_ns	hsa-mir-139	Pediatric Ependymoma	29704232	disease of cellular proliferation	DOID:5509					miR-543, miR-495-3p, miR-299-3p, miR-139-5p and miR-128-3p were identified to have CD44 positively co-regulated potential target oncogenes
tissue_expression_ns	hsa-mir-299	Pediatric Ependymoma	29704232	disease of cellular proliferation	DOID:5509					miR-543, miR-495-3p, miR-299-3p, miR-139-5p and miR-128-3p were identified to have CD44 positively co-regulated potential target oncogenes
tissue_expression_ns	hsa-mir-495	Pediatric Ependymoma	29704232	disease of cellular proliferation	DOID:5509					miR-543, miR-495-3p, miR-299-3p, miR-139-5p and miR-128-3p were identified to have CD44 positively co-regulated potential target oncogenes
tissue_expression_ns	hsa-mir-543	Pediatric Ependymoma	29704232	disease of cellular proliferation	DOID:5509					miR-543, miR-495-3p, miR-299-3p, miR-139-5p and miR-128-3p were identified to have CD44 positively co-regulated potential target oncogenes
tissue_expression_ns	hsa-mir-130b	Penis Carcinoma	28751665	reproductive system disease	DOID:3449	C60.9				hsa-miR-31, hsa-miR-34a and hsa-miR-130b, were significantly associated with over-represented pathways in cancer
tissue_expression_ns	hsa-mir-223	Penis Carcinoma	28122331	reproductive system disease	DOID:3449	C60.9				Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact.
tissue_expression_ns	hsa-mir-224	Penis Carcinoma	28122331	reproductive system disease	DOID:3449	C60.9				Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact.
tissue_expression_ns	hsa-mir-31	Penis Carcinoma	28122331	reproductive system disease	DOID:3449	C60.9				Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact.
tissue_expression_ns	hsa-mir-31	Penis Carcinoma	28751665	reproductive system disease	DOID:3449	C60.9				hsa-miR-31, hsa-miR-34a and hsa-miR-130b, were significantly associated with over-represented pathways in cancer
tissue_expression_ns	hsa-mir-34a	Penis Carcinoma	28751665	reproductive system disease	DOID:3449	C60.9				hsa-miR-31, hsa-miR-34a and hsa-miR-130b, were significantly associated with over-represented pathways in cancer
tissue_expression_ns	hsa-mir-146a	Periodontal Diseases	21789961	gastrointestinal system disease	DOID:3388	K05.6	D010510		HP:0000704	hsa-mirNA-146a, hsa-miRNA-146b, and hsa-miRNA-155, showed significant differences between inflamed and healthy gingiva.
tissue_expression_ns	hsa-mir-146b	Periodontal Diseases	21789961	gastrointestinal system disease	DOID:3388	K05.6	D010510		HP:0000704	hsa-mirNA-146a, hsa-miRNA-146b, and hsa-miRNA-155, showed significant differences between inflamed and healthy gingiva.
tissue_expression_ns	hsa-mir-155	Periodontal Diseases	21789961	gastrointestinal system disease	DOID:3388	K05.6	D010510		HP:0000704	hsa-mirNA-146a, hsa-miRNA-146b, and hsa-miRNA-155, showed significant differences between inflamed and healthy gingiva.
tissue_expression_ns	hsa-let-7a	Periodontitis	29226952	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Differential expression of microRNAs let-7a, miR-125b, miR-100, and miR-21 and interaction with NF-kB pathway genes in periodontitis pathogenesis
tissue_expression_ns	hsa-mir-100	Periodontitis	29226952	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Differential expression of microRNAs let-7a, miR-125b, miR-100, and miR-21 and interaction with NF-kB pathway genes in periodontitis pathogenesis
tissue_expression_ns	hsa-mir-125b	Periodontitis	29226952	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Differential expression of microRNAs let-7a, miR-125b, miR-100, and miR-21 and interaction with NF-kB pathway genes in periodontitis pathogenesis
tissue_expression_ns	hsa-mir-21	Periodontitis	29226952	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Differential expression of microRNAs let-7a, miR-125b, miR-100, and miR-21 and interaction with NF-kB pathway genes in periodontitis pathogenesis
tissue_expression_ns	hsa-mir-21	Peritoneal Dialysis Failure	27867039			T85.71				Peritoneal dialysis effluent miR-21 and miR-589 levels correlate with longitudinal change in peritoneal transport characteristics.
tissue_expression_ns	hsa-mir-589	Peritoneal Dialysis Failure	27867039			T85.71				Peritoneal dialysis effluent miR-21 and miR-589 levels correlate with longitudinal change in peritoneal transport characteristics.
tissue_expression_ns	hsa-mir-186	Peritoneal Neoplasms	29360196			C48.2	D010534			The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA
tissue_expression_ns	hsa-mir-21	Peritoneal Neoplasms	29360196			C48.2	D010534			The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA
tissue_expression_ns	hsa-mir-222	Peritoneal Neoplasms	29360196			C48.2	D010534			The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA
tissue_expression_ns	hsa-mir-223	Peritoneal Neoplasms	29360196			C48.2	D010534			The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA
tissue_expression_ns	hsa-mir-483	Peritoneal Neoplasms	29360196			C48.2	D010534			The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA
tissue_expression_ns	hsa-mir-21	Perlman Syndrome	24786382	syndrome	DOID:0060476		C536399	267000		Our study is the first to investigate the association between placental miRNA expression and macrosomia. Our results indicate that the expression level of miR-21 in placental tissue may be involved in the development of macrosomia.
tissue_expression_ns	hsa-let-7a-1	Pituitary Adenoma	18840638	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	let-7a: deregulation
tissue_expression_ns	hsa-let-7a-2	Pituitary Adenoma	18840638	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	let-7a: deregulation
tissue_expression_ns	hsa-let-7a-3	Pituitary Adenoma	18840638	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	let-7a: deregulation
tissue_expression_ns	hsa-mir-10b	Pituitary Adenoma	24310454	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	We established miRNA expression maps of non-functioning and gonadotropin-secreting pituitary adenomas. The most strongly differentially expressed genes were miR-124a and miR-31 in non-functioning pituitary adenomas, and miR-10b and miR-503 in gonadotropin-secreting pituitary adenomas.
tissue_expression_ns	hsa-mir-135a	Pituitary Adenoma	29374071	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	elevant compensatory mechanisms were found through the changes in miR involved in osteoblastogenesis (miR-210-5p, miR-135a-5p, miR-211, miR-23a-3p, miR-204-5p)
tissue_expression_ns	hsa-mir-141	Pituitary Adenoma	18840638	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	miR-141: deregulation
tissue_expression_ns	hsa-mir-143	Pituitary Adenoma	18840638	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	miR-143: deregulation
tissue_expression_ns	hsa-mir-145	Pituitary Adenoma	18840638	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	miR-145: deregulation
tissue_expression_ns	hsa-mir-150	Pituitary Adenoma	18840638	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	miR-150: deregulation
tissue_expression_ns	hsa-mir-15a	Pituitary Adenoma	18840638	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	miR-15a: deregulation
tissue_expression_ns	hsa-mir-16-1	Pituitary Adenoma	18840638	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	miR-16: deregulation
tissue_expression_ns	hsa-mir-16-2	Pituitary Adenoma	18840638	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	miR-16: deregulation
tissue_expression_ns	hsa-mir-181a	Pituitary Adenoma	28315020	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile.
tissue_expression_ns	hsa-mir-181b	Pituitary Adenoma	28315020	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile.
tissue_expression_ns	hsa-mir-181d	Pituitary Adenoma	28315020	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile.
tissue_expression_ns	hsa-mir-191	Pituitary Adenoma	28315020	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile.
tissue_expression_ns	hsa-mir-192	Pituitary Adenoma	21882851	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	Many aberrantly expressed miRNAs were related to various cancers (e.g., miR-125b, hepatocellular carcinoma; miR-21, leukemia; miR-16, chronic lymphocytic leukemia;miR-192, pituitary adenomas; miR-199a-3p, ovarian cancer; miR-34a, pancreatic cancer).
tissue_expression_ns	hsa-mir-204	Pituitary Adenoma	29374071	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	elevant compensatory mechanisms were found through the changes in miR involved in osteoblastogenesis (miR-210-5p, miR-135a-5p, miR-211, miR-23a-3p, miR-204-5p)
tissue_expression_ns	hsa-mir-21	Pituitary Adenoma	18840638	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	miR-21: deregulation
tissue_expression_ns	hsa-mir-210	Pituitary Adenoma	29374071	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	elevant compensatory mechanisms were found through the changes in miR involved in osteoblastogenesis (miR-210-5p, miR-135a-5p, miR-211, miR-23a-3p, miR-204-5p)
tissue_expression_ns	hsa-mir-2110	Pituitary Adenoma	29374071	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	elevant compensatory mechanisms were found through the changes in miR involved in osteoblastogenesis (miR-210-5p, miR-135a-5p, miR-211, miR-23a-3p, miR-204-5p)
tissue_expression_ns	hsa-mir-23a	Pituitary Adenoma	29374071	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	elevant compensatory mechanisms were found through the changes in miR involved in osteoblastogenesis (miR-210-5p, miR-135a-5p, miR-211, miR-23a-3p, miR-204-5p)
tissue_expression_ns	hsa-mir-26a	Pituitary Adenoma	28012286	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	Expression and Clinical Significance of miR-26a and Pleomorphic Adenoma Gene 1 (PLAG1) in Invasive Pituitary Adenoma.
tissue_expression_ns	hsa-mir-3676	Pituitary Adenoma	28315020	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile.
tissue_expression_ns	hsa-mir-383	Pituitary Adenoma	28315020	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile.
tissue_expression_ns	hsa-mir-422a	Pituitary Adenoma	24310454	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	We established miRNA expression maps of non-functioning and gonadotropin-secreting pituitary adenomas. The most strongly differentially expressed genes were miR-124a and miR-31 in non-functioning pituitary adenomas, and miR-10b and miR-503 in gonadotropin-secreting pituitary adenomas.
tissue_expression_ns	hsa-mir-422b	Pituitary Adenoma	24310454	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	We established miRNA expression maps of non-functioning and gonadotropin-secreting pituitary adenomas. The most strongly differentially expressed genes were miR-124a and miR-31 in non-functioning pituitary adenomas, and miR-10b and miR-503 in gonadotropin-secreting pituitary adenomas.
tissue_expression_ns	hsa-mir-520b	Pituitary Adenoma	24310454	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	We established miRNA expression maps of non-functioning and gonadotropin-secreting pituitary adenomas. The most strongly differentially expressed genes were miR-124a and miR-31 in non-functioning pituitary adenomas, and miR-10b and miR-503 in gonadotropin-secreting pituitary adenomas.
tissue_expression_ns	hsa-mir-523	Pituitary Adenoma	24310454	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	We established miRNA expression maps of non-functioning and gonadotropin-secreting pituitary adenomas. The most strongly differentially expressed genes were miR-124a and miR-31 in non-functioning pituitary adenomas, and miR-10b and miR-503 in gonadotropin-secreting pituitary adenomas.
tissue_expression_ns	hsa-mir-598	Pituitary Adenoma	28315020	disease of cellular proliferation	DOID:3829	D35.2	D010911	102200	HP:0002893	Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile.
tissue_expression_ns	hsa-let-7a	Pituitary Neoplasms	28300776	disease of cellular proliferation	DOID:1785	C75.1	D010911		HP:0040277	Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream.
tissue_expression_ns	hsa-let-7b	Pituitary Neoplasms	28300776	disease of cellular proliferation	DOID:1785	C75.1	D010911		HP:0040277	Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream.
tissue_expression_ns	hsa-let-7c	Pituitary Neoplasms	28300776	disease of cellular proliferation	DOID:1785	C75.1	D010911		HP:0040277	Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream.
tissue_expression_ns	hsa-let-7d	Pituitary Neoplasms	28300776	disease of cellular proliferation	DOID:1785	C75.1	D010911		HP:0040277	Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream.
tissue_expression_ns	hsa-let-7e	Pituitary Neoplasms	28300776	disease of cellular proliferation	DOID:1785	C75.1	D010911		HP:0040277	Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream.
tissue_expression_ns	hsa-let-7f	Pituitary Neoplasms	28300776	disease of cellular proliferation	DOID:1785	C75.1	D010911		HP:0040277	Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream.
tissue_expression_ns	hsa-let-7g	Pituitary Neoplasms	28300776	disease of cellular proliferation	DOID:1785	C75.1	D010911		HP:0040277	Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream.
tissue_expression_ns	hsa-let-7i	Pituitary Neoplasms	28300776	disease of cellular proliferation	DOID:1785	C75.1	D010911		HP:0040277	Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream.
tissue_expression_ns	hsa-mir-126	Pleural Mesothelioma	24912849	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	Diagnostic potential of miR-126, miR-143, miR-145, and miR-652 in malignant pleural mesothelioma.
tissue_expression_ns	hsa-mir-941	Polyangiitis	27755585							MicroRNA-941 Expression in Polymorphonuclear Granulocytes Is Not Related to Granulomatosis with Polyangiitis.
tissue_expression_ns	hsa-mir-133	Polycystic Kidney Disease	24489795			Q61.19	D007690	PS173900	HP:0000113	We found that in ADPKD urine specimens, miRNA previously implicated as kidney tumor suppressors (miR-1 and miR-133), as well as miRNA of presumed inflammatory and fibroblast cell origin (miR-223/miR-199), are dysregulated when compared to other CKD patients. Concordant with findings in the primary tubule epithelial cell model, this suggests roles for dysregulated miRNA in ADPKD pathogenesis and potential use as biomarkers. We intend to assess prognostic potential of miRNA in a followup analysis.
tissue_expression_ns	hsa-mir-143	Polycystic Kidney Disease	24489795			Q61.19	D007690	PS173900	HP:0000113	We found that in ADPKD urine specimens, miRNA previously implicated as kidney tumor suppressors (miR-1 and miR-133), as well as miRNA of presumed inflammatory and fibroblast cell origin (miR-223/miR-199), are dysregulated when compared to other CKD patients. Concordant with findings in the primary tubule epithelial cell model, this suggests roles for dysregulated miRNA in ADPKD pathogenesis and potential use as biomarkers. We intend to assess prognostic potential of miRNA in a followup analysis.
tissue_expression_ns	hsa-mir-199	Polycystic Kidney Disease	24489795			Q61.19	D007690	PS173900	HP:0000113	We found that in ADPKD urine specimens, miRNA previously implicated as kidney tumor suppressors (miR-1 and miR-133), as well as miRNA of presumed inflammatory and fibroblast cell origin (miR-223/miR-199), are dysregulated when compared to other CKD patients. Concordant with findings in the primary tubule epithelial cell model, this suggests roles for dysregulated miRNA in ADPKD pathogenesis and potential use as biomarkers. We intend to assess prognostic potential of miRNA in a followup analysis.
tissue_expression_ns	hsa-mir-205	Polycystic Kidney Disease	24489795			Q61.19	D007690	PS173900	HP:0000113	We found that in ADPKD urine specimens, miRNA previously implicated as kidney tumor suppressors (miR-1 and miR-133), as well as miRNA of presumed inflammatory and fibroblast cell origin (miR-223/miR-199), are dysregulated when compared to other CKD patients. Concordant with findings in the primary tubule epithelial cell model, this suggests roles for dysregulated miRNA in ADPKD pathogenesis and potential use as biomarkers. We intend to assess prognostic potential of miRNA in a followup analysis.
tissue_expression_ns	hsa-mir-223	Polycystic Kidney Disease	24489795			Q61.19	D007690	PS173900	HP:0000113	We found that in ADPKD urine specimens, miRNA previously implicated as kidney tumor suppressors (miR-1 and miR-133), as well as miRNA of presumed inflammatory and fibroblast cell origin (miR-223/miR-199), are dysregulated when compared to other CKD patients. Concordant with findings in the primary tubule epithelial cell model, this suggests roles for dysregulated miRNA in ADPKD pathogenesis and potential use as biomarkers. We intend to assess prognostic potential of miRNA in a followup analysis.
tissue_expression_ns	hsa-mir-135a	Polycystic Ovarian Syndrome	24390626	syndrome	DOID:11612	E28.2	D011085	184700		Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome.
tissue_expression_ns	hsa-mir-18b	Polycystic Ovarian Syndrome	24390626	syndrome	DOID:11612	E28.2	D011085	184700		Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome.
tissue_expression_ns	hsa-mir-223	Polycystic Ovarian Syndrome	27777110	syndrome	DOID:11612	E28.2	D011085	184700		Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model.
tissue_expression_ns	hsa-mir-32	Polycystic Ovarian Syndrome	24390626	syndrome	DOID:11612	E28.2	D011085	184700		Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome.
tissue_expression_ns	hsa-mir-324	Polycystic Ovarian Syndrome	27777110	syndrome	DOID:11612	E28.2	D011085	184700		Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model.
tissue_expression_ns	hsa-mir-34c	Polycystic Ovarian Syndrome	24390626	syndrome	DOID:11612	E28.2	D011085	184700		Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome.
tissue_expression_ns	hsa-mir-375	Polycystic Ovarian Syndrome	27777110	syndrome	DOID:11612	E28.2	D011085	184700		Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model.
tissue_expression_ns	hsa-mir-484	Polycystic Ovarian Syndrome	27777110	syndrome	DOID:11612	E28.2	D011085	184700		Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model.
tissue_expression_ns	hsa-mir-9	Polycystic Ovarian Syndrome	24390626	syndrome	DOID:11612	E28.2	D011085	184700		Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome.
tissue_expression_ns	hsa-mir-155	Porphyromonas Gingivalis	28069815				D016966			Identification and Characterization of MicroRNA Differentially Expressed in Macrophages Exposed to Porphyromonas gingivalis Infection.
tissue_expression_ns	hsa-mir-125a	Post-Traumatic Stress Disorder	24759737	disease of mental health	DOID:2055	F43.1	D013313			Dysregulation in microRNA expression is associated with alterations in immune functions in combat veterans with post-traumatic stress disorder.
tissue_expression_ns	hsa-mir-106a	Preeclampsia	25499681	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	facilitate further investigation of aberrant expression of miRNAs in the pathology of preeclampsia.
tissue_expression_ns	hsa-mir-152	Preeclampsia	19285651	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	miR-152: expressed differentially in preeclamptic placentas vs normal controls
tissue_expression_ns	hsa-mir-16	Preeclampsia	23083510	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Together, these data suggest that the alteration of miR-16 expression in decidua-derived mesenchymal stem cells may be involved in the development of pre-eclampsia.
tissue_expression_ns	hsa-mir-182	Preeclampsia	17346547	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Differential expression between preeclampsia and the control group (miR-210, miR-182) and between preeclampsia + SGA and the control group (miR-210, miR-182*, and others) was found.
tissue_expression_ns	hsa-mir-191	Preeclampsia	23830491	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management.
tissue_expression_ns	hsa-mir-197	Preeclampsia	23830491	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management.
tissue_expression_ns	hsa-mir-198	Preeclampsia	23830491	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management.
tissue_expression_ns	hsa-mir-202	Preeclampsia	23830491	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management.
tissue_expression_ns	hsa-mir-204	Preeclampsia	23830491	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management.
tissue_expression_ns	hsa-mir-210	Preeclampsia	19285651	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	miR-210: expressed differentially in preeclamptic placentas vs normal controls
tissue_expression_ns	hsa-mir-210	Preeclampsia	17346547	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Differential expression between preeclampsia and the control group (miR-210, miR-182) and between preeclampsia + SGA and the control group (miR-210, miR-182*, and others) was found.
tissue_expression_ns	hsa-mir-25	Preeclampsia	23830491	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management.
tissue_expression_ns	hsa-mir-26a	Preeclampsia	23830491	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management.
tissue_expression_ns	hsa-mir-26b	Preeclampsia	23830491	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management.
tissue_expression_ns	hsa-mir-296	Preeclampsia	23830491	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management.
tissue_expression_ns	hsa-mir-342	Preeclampsia	23830491	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management.
tissue_expression_ns	hsa-mir-363	Preeclampsia	25499681	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	facilitate further investigation of aberrant expression of miRNAs in the pathology of preeclampsia.
tissue_expression_ns	hsa-mir-411	Preeclampsia	19285651	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	miR-411: expressed differentially in preeclamptic placentas vs normal controls
tissue_expression_ns	hsa-mir-517a	Preeclampsia	25799546	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia.
tissue_expression_ns	hsa-mir-517b	Preeclampsia	25799546	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia.
tissue_expression_ns	hsa-mir-517c	Preeclampsia	25799546	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia.
tissue_expression_ns	hsa-mir-92b	Preeclampsia	23830491	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management.
tissue_expression_ns	hsa-mir-95	Preeclampsia	23830491	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management.
tissue_expression_ns	hsa-mir-126	Prolactinoma	25064468	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma.
tissue_expression_ns	hsa-mir-136	Prolactinoma	25064468	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma.
tissue_expression_ns	hsa-mir-142	Prolactinoma	25064468	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma.
tissue_expression_ns	hsa-mir-144	Prolactinoma	25064468	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma.
tissue_expression_ns	hsa-mir-17	Prolactinoma	25064468	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma.
tissue_expression_ns	hsa-mir-22	Prolactinoma	25064468	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma.
tissue_expression_ns	hsa-mir-30a	Prolactinoma	25064468	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma.
tissue_expression_ns	hsa-mir-382	Prolactinoma	25064468	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma.
tissue_expression_ns	hsa-mir-451	Prolactinoma	25064468	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma.
tissue_expression_ns	hsa-mir-486	Prolactinoma	25064468	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma.
tissue_expression_ns	hsa-mir-92a	Prolactinoma	25064468	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma.
tissue_expression_ns	Hsa-mir-93	Prolactinoma	25064468	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma.
tissue_expression_ns	hsa-let-7	Prostate Neoplasms	24431212	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic.
tissue_expression_ns	hsa-let-7	Prostate Neoplasms	24452514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment.
tissue_expression_ns	hsa-let-7a	Prostate Neoplasms	20944140	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of our study was to assess the expression of mir-20a, let-7a, miR-15a and miR-16 in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) tissue and to investigate the relation between the expression of miRNAs and the clinicopathological features of PCa.
tissue_expression_ns	hsa-let-7c	Prostate Neoplasms	17891175	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	We have analysed expression of 328 known and 152 novel human miRNAs in 10 benign peripheral zone tissues and 16 prostate cancer tissues using microarrays and found widespread, but not universal, downregulation of miRNAs in clinically localized prostate cancer relative to benign peripheral zone tissue.These findings have been verified by real-time RT-PCR assays on select miRNAs, including miR-125b, miR-145 and let-7c.
tissue_expression_ns	hsa-let-7d	Prostate Neoplasms	20873592	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The expression profiles of the microRNAs let-7d, let-7g, miR-98, miR-96, miR-182 and miR-183 reflect the biological behavior of PCa to some extent, and might be important biomarkers for the early detection and prognostic assessment of prostate cancer.
tissue_expression_ns	hsa-let-7g	Prostate Neoplasms	20873592	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The expression profiles of the microRNAs let-7d, let-7g, miR-98, miR-96, miR-182 and miR-183 reflect the biological behavior of PCa to some extent, and might be important biomarkers for the early detection and prognostic assessment of prostate cancer.
tissue_expression_ns	hsa-mir-1	Prostate Neoplasms	24452514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment.
tissue_expression_ns	hsa-mir-1	Prostate Neoplasms	24967583	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-1 and miR-133b are differentially expressed in patients with recurrent prostate cancer.
tissue_expression_ns	hsa-mir-100	Prostate Neoplasms	23621234	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	In conclusion, expression changes in miRNAs of miR-146a, miR-100, miR-425, miR-193a-3p and, miR-106b in metformin-treated cells may be important.
tissue_expression_ns	hsa-mir-101	Prostate Neoplasms	20539944	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa.
tissue_expression_ns	hsa-mir-106b	Prostate Neoplasms	24452514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment.
tissue_expression_ns	hsa-mir-106b	Prostate Neoplasms	23621234	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	In conclusion, expression changes in miRNAs of miR-146a, miR-100, miR-425, miR-193a-3p and, miR-106b in metformin-treated cells may be important.
tissue_expression_ns	hsa-mir-1-1	Prostate Neoplasms	22210864	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancer.
tissue_expression_ns	hsa-mir-1-2	Prostate Neoplasms	22210864	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancer.
tissue_expression_ns	hsa-mir-125b	Prostate Neoplasms	24452514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment.
tissue_expression_ns	hsa-mir-125b	Prostate Neoplasms	17891175	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	We have analysed expression of 328 known and 152 novel human miRNAs in 10 benign peripheral zone tissues and 16 prostate cancer tissues using microarrays and found widespread, but not universal, downregulation of miRNAs in clinically localized prostate cancer relative to benign peripheral zone tissue.These findings have been verified by real-time RT-PCR assays on select miRNAs, including miR-125b, miR-145 and let-7c.
tissue_expression_ns	hsa-mir-125b	Prostate Neoplasms	20539944	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa.
tissue_expression_ns	hsa-mir-125b	Prostate Neoplasms	20890088	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Normalization of the four miRNAs hsa-miR-96, hsa- miR-125b, hsa-miR-205, and hsa-miR-375, which were previously shown to be regulated, shows that normalization to hsa-mir-16 can lead to biased results.
tissue_expression_ns	hsa-mir-126	Prostate Neoplasms	20539944	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa.
tissue_expression_ns	hsa-mir-127	Prostate Neoplasms	28239051	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	MicroRNA expression profiling in canine prostate cancer.
tissue_expression_ns	hsa-mir-127	Prostate Neoplasms	28621736	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	A Panel of MicroRNAs as Diagnostic Biomarkers for the Identification of Prostate Cancer.
tissue_expression_ns	hsa-mir-133b	Prostate Neoplasms	24967583	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-1 and miR-133b are differentially expressed in patients with recurrent prostate cancer.
tissue_expression_ns	hsa-mir-134	Prostate Neoplasms	24431212	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic.
tissue_expression_ns	hsa-mir-135a	Prostate Neoplasms	18831788	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	In addition, microRNA microarray data from other studies confirm that several predicted microRNAs, including miR-21, miR-135a, and miR-135b, demonstrate differential expression in prostate cancer cells, comparing with normal tissues.
tissue_expression_ns	hsa-mir-135b	Prostate Neoplasms	18831788	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	In addition, microRNA microarray data from other studies confirm that several predicted microRNAs, including miR-21, miR-135a, and miR-135b, demonstrate differential expression in prostate cancer cells, comparing with normal tissues.
tissue_expression_ns	hsa-mir-138	Prostate Neoplasms	24431212	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic.
tissue_expression_ns	hsa-mir-141	Prostate Neoplasms	26751899	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miRNAs as novel biomarkers in the management of prostate cancer.
tissue_expression_ns	hsa-mir-141	Prostate Neoplasms	20014922	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Promising molecular markers identified from gene expression profiling studies include AMACR, EZH2, TMPRSS2-ERG, miR-221 and miR-141, which are described in more detail.
tissue_expression_ns	hsa-mir-141	Prostate Neoplasms	20539944	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa.
tissue_expression_ns	hsa-mir-143	Prostate Neoplasms	24431212	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic.
tissue_expression_ns	hsa-mir-143	Prostate Neoplasms	21400514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The differential expression of miRNAs miR-375, miR-143 and miR-145 was validated by quantitative PCR. MiRNA in situ hybridization revealed that the differential expression is cancer-cell associated.
tissue_expression_ns	hsa-mir-145	Prostate Neoplasms	17891175	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	We have analysed expression of 328 known and 152 novel human miRNAs in 10 benign peripheral zone tissues and 16 prostate cancer tissues using microarrays and found widespread, but not universal, downregulation of miRNAs in clinically localized prostate cancer relative to benign peripheral zone tissue.These findings have been verified by real-time RT-PCR assays on select miRNAs, including miR-125b, miR-145 and let-7c.
tissue_expression_ns	hsa-mir-145	Prostate Neoplasms	21400514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The differential expression of miRNAs miR-375, miR-143 and miR-145 was validated by quantitative PCR. MiRNA in situ hybridization revealed that the differential expression is cancer-cell associated.
tissue_expression_ns	hsa-mir-146a	Prostate Neoplasms	23621234	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	In conclusion, expression changes in miRNAs of miR-146a, miR-100, miR-425, miR-193a-3p and, miR-106b in metformin-treated cells may be important.
tissue_expression_ns	hsa-mir-146a	Prostate Neoplasms	20539944	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa.
tissue_expression_ns	hsa-mir-155	Prostate Neoplasms	24431212	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic.
tissue_expression_ns	hsa-mir-15a	Prostate Neoplasms	20944140	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of our study was to assess the expression of mir-20a, let-7a, miR-15a and miR-16 in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) tissue and to investigate the relation between the expression of miRNAs and the clinicopathological features of PCa.
tissue_expression_ns	hsa-mir-16	Prostate Neoplasms	20890088	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Normalization of the four miRNAs hsa-miR-96, hsa- miR-125b, hsa-miR-205, and hsa-miR-375, which were previously shown to be regulated, shows that normalization to hsa-mir-16 can lead to biased results.
tissue_expression_ns	hsa-mir-16	Prostate Neoplasms	20944140	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of our study was to assess the expression of mir-20a, let-7a, miR-15a and miR-16 in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) tissue and to investigate the relation between the expression of miRNAs and the clinicopathological features of PCa.
tissue_expression_ns	hsa-mir-181c	Prostate Neoplasms	24431212	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic.
tissue_expression_ns	hsa-mir-181d	Prostate Neoplasms	24431212	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic.
tissue_expression_ns	hsa-mir-182	Prostate Neoplasms	24518785	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Results show that miR-182 and 187 are promising biomarkers for prostate cancer prognosis to identify patients at risk for progression and for diagnosis to improve the predictive capability of existing biomarkers.
tissue_expression_ns	hsa-mir-182	Prostate Neoplasms	26484677	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Integrated Analysis Reveals together miR-182, miR-200c and miR-221 Can Help in the Diagnosis of Prostate Cancer.
tissue_expression_ns	hsa-mir-182	Prostate Neoplasms	23184537	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Expression of MicroRNAs associated with Gleason grading system in prostate cancer: miR-182-5p is a useful marker for high grade prostate cancer
tissue_expression_ns	hsa-mir-182	Prostate Neoplasms	20873592	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The expression profiles of the microRNAs let-7d, let-7g, miR-98, miR-96, miR-182 and miR-183 reflect the biological behavior of PCa to some extent, and might be important biomarkers for the early detection and prognostic assessment of prostate cancer.
tissue_expression_ns	hsa-mir-183	Prostate Neoplasms	25720086	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Urinary miR-183 and miR-205 do not surpass PCA3 in urine as predictive markers for prostate biopsy outcome despite their highly dysregulated expression in prostate cancer tissue.
tissue_expression_ns	hsa-mir-183	Prostate Neoplasms	20873592	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The expression profiles of the microRNAs let-7d, let-7g, miR-98, miR-96, miR-182 and miR-183 reflect the biological behavior of PCa to some extent, and might be important biomarkers for the early detection and prognostic assessment of prostate cancer.
tissue_expression_ns	hsa-mir-187	Prostate Neoplasms	24518785	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Results show that miR-182 and 187 are promising biomarkers for prostate cancer prognosis to identify patients at risk for progression and for diagnosis to improve the predictive capability of existing biomarkers.
tissue_expression_ns	hsa-mir-193a	Prostate Neoplasms	23621234	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	In conclusion, expression changes in miRNAs of miR-146a, miR-100, miR-425, miR-193a-3p and, miR-106b in metformin-treated cells may be important.
tissue_expression_ns	hsa-mir-200a	Prostate Neoplasms	20539944	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa.
tissue_expression_ns	hsa-mir-200b	Prostate Neoplasms	20539944	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa.
tissue_expression_ns	hsa-mir-200c	Prostate Neoplasms	26484677	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Integrated Analysis Reveals together miR-182, miR-200c and miR-221 Can Help in the Diagnosis of Prostate Cancer.
tissue_expression_ns	hsa-mir-200c	Prostate Neoplasms	20539944	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa.
tissue_expression_ns	hsa-mir-205	Prostate Neoplasms	24431212	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic.
tissue_expression_ns	hsa-mir-205	Prostate Neoplasms	24452514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment.
tissue_expression_ns	hsa-mir-205	Prostate Neoplasms	25720086	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Urinary miR-183 and miR-205 do not surpass PCA3 in urine as predictive markers for prostate biopsy outcome despite their highly dysregulated expression in prostate cancer tissue.
tissue_expression_ns	hsa-mir-205	Prostate Neoplasms	24167554	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	MicroRNA profiling in prostate cancer--the diagnostic potential of urinary miR-205 and miR-214.
tissue_expression_ns	hsa-mir-205	Prostate Neoplasms	20890088	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Normalization of the four miRNAs hsa-miR-96, hsa- miR-125b, hsa-miR-205, and hsa-miR-375, which were previously shown to be regulated, shows that normalization to hsa-mir-16 can lead to biased results.
tissue_expression_ns	hsa-mir-20a	Prostate Neoplasms	24452514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment.
tissue_expression_ns	hsa-mir-20a	Prostate Neoplasms	20944140	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of our study was to assess the expression of mir-20a, let-7a, miR-15a and miR-16 in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) tissue and to investigate the relation between the expression of miRNAs and the clinicopathological features of PCa.
tissue_expression_ns	hsa-mir-21	Prostate Neoplasms	24452514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment.
tissue_expression_ns	hsa-mir-21	Prostate Neoplasms	26751899	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miRNAs as novel biomarkers in the management of prostate cancer.
tissue_expression_ns	hsa-mir-21	Prostate Neoplasms	18831788	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	In addition, microRNA microarray data from other studies confirm that several predicted microRNAs, including miR-21, miR-135a, and miR-135b, demonstrate differential expression in prostate cancer cells, comparing with normal tissues.
tissue_expression_ns	hsa-mir-21	Prostate Neoplasms	20539944	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa.
tissue_expression_ns	hsa-mir-214	Prostate Neoplasms	24167554	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	MicroRNA profiling in prostate cancer--the diagnostic potential of urinary miR-205 and miR-214.
tissue_expression_ns	hsa-mir-221	Prostate Neoplasms	26484677	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Integrated Analysis Reveals together miR-182, miR-200c and miR-221 Can Help in the Diagnosis of Prostate Cancer.
tissue_expression_ns	hsa-mir-221	Prostate Neoplasms	20014922	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Promising molecular markers identified from gene expression profiling studies include AMACR, EZH2, TMPRSS2-ERG, miR-221 and miR-141, which are described in more detail.
tissue_expression_ns	hsa-mir-221	Prostate Neoplasms	20539944	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa.
tissue_expression_ns	hsa-mir-222	Prostate Neoplasms	20539944	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa.
tissue_expression_ns	hsa-mir-330	Prostate Neoplasms	20539944	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa.
tissue_expression_ns	hsa-mir-34	Prostate Neoplasms	20539944	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa.
tissue_expression_ns	hsa-mir-34a	Prostate Neoplasms	24452514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment.
tissue_expression_ns	hsa-mir-34b	Prostate Neoplasms	28039468	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians.
tissue_expression_ns	hsa-mir-34c	Prostate Neoplasms	24431212	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic.
tissue_expression_ns	hsa-mir-373	Prostate Neoplasms	24431212	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic.
tissue_expression_ns	hsa-mir-375	Prostate Neoplasms	26751899	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miRNAs as novel biomarkers in the management of prostate cancer.
tissue_expression_ns	hsa-mir-375	Prostate Neoplasms	20890088	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Normalization of the four miRNAs hsa-miR-96, hsa- miR-125b, hsa-miR-205, and hsa-miR-375, which were previously shown to be regulated, shows that normalization to hsa-mir-16 can lead to biased results.
tissue_expression_ns	hsa-mir-375	Prostate Neoplasms	21400514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The differential expression of miRNAs miR-375, miR-143 and miR-145 was validated by quantitative PCR. MiRNA in situ hybridization revealed that the differential expression is cancer-cell associated.
tissue_expression_ns	hsa-mir-425	Prostate Neoplasms	23621234	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	In conclusion, expression changes in miRNAs of miR-146a, miR-100, miR-425, miR-193a-3p and, miR-106b in metformin-treated cells may be important.
tissue_expression_ns	hsa-mir-429	Prostate Neoplasms	20539944	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa.
tissue_expression_ns	hsa-mir-503	Prostate Neoplasms	29164842	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-503 is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma andseveral others
tissue_expression_ns	hsa-mir-521	Prostate Neoplasms	24452514	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment.
tissue_expression_ns	hsa-mir-96	Prostate Neoplasms	20873592	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The expression profiles of the microRNAs let-7d, let-7g, miR-98, miR-96, miR-182 and miR-183 reflect the biological behavior of PCa to some extent, and might be important biomarkers for the early detection and prognostic assessment of prostate cancer.
tissue_expression_ns	hsa-mir-96	Prostate Neoplasms	20890088	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Normalization of the four miRNAs hsa-miR-96, hsa- miR-125b, hsa-miR-205, and hsa-miR-375, which were previously shown to be regulated, shows that normalization to hsa-mir-16 can lead to biased results.
tissue_expression_ns	hsa-mir-98	Prostate Neoplasms	20873592	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The expression profiles of the microRNAs let-7d, let-7g, miR-98, miR-96, miR-182 and miR-183 reflect the biological behavior of PCa to some extent, and might be important biomarkers for the early detection and prognostic assessment of prostate cancer.
tissue_expression_ns	hsa-mir-100	Psoriasis	21807764	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	deregulated
tissue_expression_ns	hsa-mir-106a	Psoriasis	28077577	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity.
tissue_expression_ns	hsa-mir-142	Psoriasis	21807764	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	miR-142-3p: deregulated
tissue_expression_ns	hsa-mir-146a	Psoriasis	25662483	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	In the mouse model of Aldara-induced skin inflammation, the level of miR-146a increased
tissue_expression_ns	hsa-mir-146a	Psoriasis	27562321	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	MicroRNA-146a and miR-99a are potential biomarkers for disease activity and clinical efficacy assessment in psoriasis patients treated with traditional Chinese medicine.
tissue_expression_ns	hsa-mir-146a	Psoriasis	28077577	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity.
tissue_expression_ns	hsa-mir-150	Psoriasis	21687694	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	differentially expressed
tissue_expression_ns	hsa-mir-150	Psoriasis	28077577	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity.
tissue_expression_ns	hsa-mir-155	Psoriasis	28077577	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity.
tissue_expression_ns	hsa-mir-197	Psoriasis	21687694	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	differentially expressed
tissue_expression_ns	hsa-mir-19a	Psoriasis	28077577	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity.
tissue_expression_ns	hsa-mir-203	Psoriasis	26559308	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	Key roles of several unique miRNAs, such as miR-203 and miR-125b, in inflammatory responses and immune dysfunction, as well as hyperproliferative disorders of psoriatic lesions have been revealed.
tissue_expression_ns	hsa-mir-21	Psoriasis	21807764	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	deregulated
tissue_expression_ns	hsa-mir-21	Psoriasis	28077577	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity.
tissue_expression_ns	hsa-mir-223	Psoriasis	21807764	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	miR-223 and miR-223*: deregulated
tissue_expression_ns	hsa-mir-378a	Psoriasis	21807764	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	deregulated
tissue_expression_ns	hsa-mir-423	Psoriasis	21687694	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	differentially expressed
tissue_expression_ns	hsa-mir-99a	Psoriasis	27562321	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	MicroRNA-146a and miR-99a are potential biomarkers for disease activity and clinical efficacy assessment in psoriasis patients treated with traditional Chinese medicine.
tissue_expression_ns	hsa-mir-129	Psychiatric Disorders	24246224				D001523	604363		Metabolic stress-induced microRNA and mRNA expression profiles of human fibroblasts.
tissue_expression_ns	hsa-mir-146b	Psychiatric Disorders	24246224				D001523	604363		Metabolic stress-induced microRNA and mRNA expression profiles of human fibroblasts.
tissue_expression_ns	hsa-mir-543	Psychiatric Disorders	24246224				D001523	604363		Metabolic stress-induced microRNA and mRNA expression profiles of human fibroblasts.
tissue_expression_ns	hsa-mir-550a	Psychiatric Disorders	24246224				D001523	604363		Metabolic stress-induced microRNA and mRNA expression profiles of human fibroblasts.
tissue_expression_ns	hsa-mir-1246	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-1308	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-141	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-143	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-18a	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-1972	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-1973	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-200a	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-200b	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-210	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-211	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-29b	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-31	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-3172	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-3175	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-375	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-451	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-486	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-663b	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-665	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-675	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-mir-934	Pterygium	23872359	nervous system disease	DOID:0002116	H11.0	D011625	178200		miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.
tissue_expression_ns	hsa-let-7f	Pulmonary Sarcoidosis	26768132	immune system disease	DOID:13406	D86.0	D017565			The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value.
tissue_expression_ns	hsa-mir-128a	Pulmonary Sarcoidosis	26768132	immune system disease	DOID:13406	D86.0	D017565			The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value.
tissue_expression_ns	hsa-mir-130a	Pulmonary Sarcoidosis	26768132	immune system disease	DOID:13406	D86.0	D017565			The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value.
tissue_expression_ns	hsa-mir-15b	Pulmonary Sarcoidosis	26768132	immune system disease	DOID:13406	D86.0	D017565			The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value.
tissue_expression_ns	hsa-mir-16	Pulmonary Sarcoidosis	26768132	immune system disease	DOID:13406	D86.0	D017565			The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value.
tissue_expression_ns	hsa-mir-192	Pulmonary Sarcoidosis	26768132	immune system disease	DOID:13406	D86.0	D017565			The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value.
tissue_expression_ns	hsa-mir-20a	Pulmonary Sarcoidosis	26768132	immune system disease	DOID:13406	D86.0	D017565			The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value.
tissue_expression_ns	hsa-mir-221	Pulmonary Sarcoidosis	26768132	immune system disease	DOID:13406	D86.0	D017565			The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value.
tissue_expression_ns	hsa-mir-222	Pulmonary Sarcoidosis	26768132	immune system disease	DOID:13406	D86.0	D017565			The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value.
tissue_expression_ns	hsa-mir-222	Pulmonary Sarcoidosis	26696750	immune system disease	DOID:13406	D86.0	D017565			miRNAs in sarcoid BAL cells detected deregulation of miR-146a, miR-150,  miR-202, miR-204, and miR-222 expression comparing to controls
tissue_expression_ns	hsa-let-7g	Rectal Neoplasms	26937645	disease of cellular proliferation	DOID:1984		D012004			We recommend the mean expression of miR-27a, miR-193a-5p and let-7g as normalisation factor, when performing miRNA expression analyses by RT-qPCR on rectal cancer tissue.
tissue_expression_ns	hsa-mir-193a	Rectal Neoplasms	26937645	disease of cellular proliferation	DOID:1984		D012004			We recommend the mean expression of miR-27a, miR-193a-5p and let-7g as normalisation factor, when performing miRNA expression analyses by RT-qPCR on rectal cancer tissue.
tissue_expression_ns	hsa-mir-21	Rectal Neoplasms	25953218	disease of cellular proliferation	DOID:1984		D012004			MicroRNA-21 expression efficiently predicts preoperative chemoradiotherapy pathological response in locally advanced rectal cancer.
tissue_expression_ns	hsa-mir-27a	Rectal Neoplasms	26937645	disease of cellular proliferation	DOID:1984		D012004			We recommend the mean expression of miR-27a, miR-193a-5p and let-7g as normalisation factor, when performing miRNA expression analyses by RT-qPCR on rectal cancer tissue.
tissue_expression_ns	hsa-mir-645	Rectal Neoplasms	26937645	disease of cellular proliferation	DOID:1984		D012004			We recommend the mean expression of miR-27a, miR-193a-5p and let-7g as normalisation factor, when performing miRNA expression analyses by RT-qPCR on rectal cancer tissue.
tissue_expression_ns	hsa-mir-630	Rectum Adenocarcinoma	27225591	disease of cellular proliferation	DOID:1996	C20				The miR-630 appeared only with the NR patients and was anti-correlated with a single transcript: RAB5B.
tissue_expression_ns	hsa-mir-125b-2	Recurrent Spontaneous Abortion	24686457			O03	D000022			Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients.
tissue_expression_ns	hsa-mir-184	Recurrent Spontaneous Abortion	24686457			O03	D000022			Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients.
tissue_expression_ns	hsa-mir-187	Recurrent Spontaneous Abortion	24686457			O03	D000022			Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients.
tissue_expression_ns	hsa-mir-3175	Recurrent Spontaneous Abortion	24686457			O03	D000022			Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients.
tissue_expression_ns	hsa-mir-4672	Recurrent Spontaneous Abortion	24686457			O03	D000022			Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients.
tissue_expression_ns	hsa-mir-517c	Recurrent Spontaneous Abortion	24686457			O03	D000022			Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients.
tissue_expression_ns	hsa-mir-519a-1	Recurrent Spontaneous Abortion	24686457			O03	D000022			Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients.
tissue_expression_ns	hsa-mir-520f	Recurrent Spontaneous Abortion	24686457			O03	D000022			Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients.
tissue_expression_ns	hsa-mir-520h	Recurrent Spontaneous Abortion	24686457			O03	D000022			Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients.
tissue_expression_ns	hsa-mir-522	Recurrent Spontaneous Abortion	24686457			O03	D000022			Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients.
tissue_expression_ns	hsa-let-7d	Reproductive System Disease	27789200	reproductive system disease	DOID:15					A number of these differentially expressed miRNAs have previously been associated with adipogenesis(e.g. let-7d*, miR-103-2*, -130b, -146b-5-p, -29c, and -26b)
tissue_expression_ns	hsa-mir-103-2	Reproductive System Disease	27789200	reproductive system disease	DOID:15					A number of these differentially expressed miRNAs have previously been associated with adipogenesis(e.g. let-7d*, miR-103-2*, -130b, -146b-5-p, -29c, and -26b)
tissue_expression_ns	hsa-mir-130b	Reproductive System Disease	27789200	reproductive system disease	DOID:15					A number of these differentially expressed miRNAs have previously been associated with adipogenesis(e.g. let-7d*, miR-103-2*, -130b, -146b-5-p, -29c, and -26b)
tissue_expression_ns	hsa-mir-146b	Reproductive System Disease	27789200	reproductive system disease	DOID:15					A number of these differentially expressed miRNAs have previously been associated with adipogenesis(e.g. let-7d*, miR-103-2*, -130b, -146b-5-p, -29c, and -26b)
tissue_expression_ns	hsa-mir-26b	Reproductive System Disease	27789200	reproductive system disease	DOID:15					A number of these differentially expressed miRNAs have previously been associated with adipogenesis(e.g. let-7d*, miR-103-2*, -130b, -146b-5-p, -29c, and -26b)
tissue_expression_ns	hsa-mir-29c	Reproductive System Disease	27789200	reproductive system disease	DOID:15					A number of these differentially expressed miRNAs have previously been associated with adipogenesis(e.g. let-7d*, miR-103-2*, -130b, -146b-5-p, -29c, and -26b)
tissue_expression_ns	hsa-mir-155	Respiratory Syncytial Virus Pneumonia	25884957	disease by infectious agent	DOID:1273	J12.1	D018357			microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-κB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV.
tissue_expression_ns	hsa-mir-16	Respiratory Syncytial Virus Pneumonia	25884957	disease by infectious agent	DOID:1273	J12.1	D018357			microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-κB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV.
tissue_expression_ns	hsa-mir-203a	Respiratory Syncytial Virus Pneumonia	25884957	disease by infectious agent	DOID:1273	J12.1	D018357			microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-κB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV.
tissue_expression_ns	hsa-mir-27b	Respiratory Syncytial Virus Pneumonia	25884957	disease by infectious agent	DOID:1273	J12.1	D018357			microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-κB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV.
tissue_expression_ns	hsa-mir-29c	Respiratory Syncytial Virus Pneumonia	25884957	disease by infectious agent	DOID:1273	J12.1	D018357			microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-κB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV.
tissue_expression_ns	hsa-mir-31	Respiratory Syncytial Virus Pneumonia	25884957	disease by infectious agent	DOID:1273	J12.1	D018357			microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-κB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV.
tissue_expression_ns	hsa-mir-34b	Respiratory Syncytial Virus Pneumonia	25884957	disease by infectious agent	DOID:1273	J12.1	D018357			microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-κB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV.
tissue_expression_ns	hsa-mir-34c	Respiratory Syncytial Virus Pneumonia	25884957	disease by infectious agent	DOID:1273	J12.1	D018357			microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-κB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV.
tissue_expression_ns	hsa-mir-124-1	Rheumatoid Arthritis	22100329	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	deregulated
tissue_expression_ns	hsa-mir-124-2	Rheumatoid Arthritis	22100329	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	deregulated
tissue_expression_ns	hsa-mir-124-3	Rheumatoid Arthritis	22100329	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	deregulated
tissue_expression_ns	hsa-mir-132	Rheumatoid Arthritis	22100329	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	deregulated
tissue_expression_ns	hsa-mir-146a	Rheumatoid Arthritis	22100329	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	deregulated
tissue_expression_ns	hsa-mir-155	Rheumatoid Arthritis	22100329	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	deregulated
tissue_expression_ns	hsa-mir-15a	Rheumatoid Arthritis	22100329	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	deregulated
tissue_expression_ns	hsa-mir-16-1	Rheumatoid Arthritis	22100329	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	deregulated
tissue_expression_ns	hsa-mir-16-2	Rheumatoid Arthritis	22100329	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	deregulated
tissue_expression_ns	hsa-mir-203	Rheumatoid Arthritis	22100329	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	deregulated
tissue_expression_ns	hsa-mir-223	Rheumatoid Arthritis	22100329	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	deregulated
tissue_expression_ns	hsa-mir-346	Rheumatoid Arthritis	22100329	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	deregulated
tissue_expression_ns	hsa-mir-363	Rheumatoid Arthritis	22100329	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	deregulated
tissue_expression_ns	hsa-mir-498	Rheumatoid Arthritis	22100329	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	deregulated
tissue_expression_ns	hsa-let-7a	Salivary Gland Neoplasms	28377929	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	Expression, Mutation, and Amplification Status of EGFR and Its Correlation with Five miRNAs in Salivary Gland Tumours.
tissue_expression_ns	hsa-mir-133b	Salivary Gland Neoplasms	28377929	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	Expression, Mutation, and Amplification Status of EGFR and Its Correlation with Five miRNAs in Salivary Gland Tumours.
tissue_expression_ns	hsa-mir-140	Salivary Gland Neoplasms	28377929	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	Expression, Mutation, and Amplification Status of EGFR and Its Correlation with Five miRNAs in Salivary Gland Tumours.
tissue_expression_ns	hsa-mir-15a	Salivary Gland Neoplasms	27981346	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
tissue_expression_ns	hsa-mir-16	Salivary Gland Neoplasms	27981346	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
tissue_expression_ns	hsa-mir-17	Salivary Gland Neoplasms	27981346	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
tissue_expression_ns	hsa-mir-20a	Salivary Gland Neoplasms	27981346	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
tissue_expression_ns	hsa-mir-21	Salivary Gland Neoplasms	27981346	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
tissue_expression_ns	hsa-mir-29	Salivary Gland Neoplasms	27981346	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
tissue_expression_ns	hsa-mir-34	Salivary Gland Neoplasms	27981346	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
tissue_expression_ns	hsa-mir-34a	Salivary Gland Neoplasms	27981346	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
tissue_expression_ns	hsa-mir-99b	Salivary Gland Neoplasms	28377929	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	Expression, Mutation, and Amplification Status of EGFR and Its Correlation with Five miRNAs in Salivary Gland Tumours.
tissue_expression_ns	hsa-let-7	Schizophrenia	27748930	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	the possible role of let-7, miR-98 and miR-183 as biomarkers for Ca and SZ was investigated in our previous research studies
tissue_expression_ns	hsa-mir-183	Schizophrenia	27748930	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	the possible role of let-7, miR-98 and miR-183 as biomarkers for Ca and SZ was investigated in our previous research studies
tissue_expression_ns	hsa-mir-212	Schizophrenia	27468165	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	miR-132, miR-133a and  miR-212 were initially identified as differentially expressed in BP, miR-184 in MDD and miR-34a in both MDD and BP (although none survived multiple correction testing and must be considered preliminary).
tissue_expression_ns	hsa-mir-7	Schizophrenia	26572867	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	Here we show post-transcriptional regulation of SHANK3 expression by three microRNAs (miRNAs), miR-7, miR-34a, and miR-504.
tissue_expression_ns	hsa-mir-98	Schizophrenia	27748930	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	the possible role of let-7, miR-98 and miR-183 as biomarkers for Ca and SZ was investigated in our previous research studies
tissue_expression_ns	hsa-mir-145	Scleroderma, Systemic	22307526	musculoskeletal system disease	DOID:418	M34	D012595	181750		The expression of the miRNA was correlated with Systemic Scleroderma fibrosis
tissue_expression_ns	hsa-mir-146a	Scleroderma, Systemic	22307526	musculoskeletal system disease	DOID:418	M34	D012595	181750		The expression of the miRNA was correlated with Systemic Scleroderma fibrosis
tissue_expression_ns	hsa-mir-146b	Scleroderma, Systemic	22307526	musculoskeletal system disease	DOID:418	M34	D012595	181750		The expression of the miRNA was correlated with Systemic Scleroderma fibrosis
tissue_expression_ns	hsa-mir-21	Scleroderma, Systemic	22307526	musculoskeletal system disease	DOID:418	M34	D012595	181750		The expression of the miRNA was correlated with Systemic Scleroderma fibrosis
tissue_expression_ns	hsa-mir-29b-1	Scleroderma, Systemic	22307526	musculoskeletal system disease	DOID:418	M34	D012595	181750		The expression of the miRNA was correlated with Systemic Scleroderma fibrosis
tissue_expression_ns	hsa-mir-29b-2	Scleroderma, Systemic	22307526	musculoskeletal system disease	DOID:418	M34	D012595	181750		The expression of the miRNA was correlated with Systemic Scleroderma fibrosis
tissue_expression_ns	hsa-mir-31	Scleroderma, Systemic	22307526	musculoskeletal system disease	DOID:418	M34	D012595	181750		The expression of the miRNA was correlated with Systemic Scleroderma fibrosis
tissue_expression_ns	hsa-mir-503	Scleroderma, Systemic	22307526	musculoskeletal system disease	DOID:418	M34	D012595	181750		The expression of the miRNA was correlated with Systemic Scleroderma fibrosis
tissue_expression_ns	hsa-mir-223	Sepsis	27129807			A41.9	D018805		HP:0100806	miR-223 that has been reported to be abnormally expressed in several diseases like diabetes-type2, sepsis, rheumatoid arthritis, viral infections likes' human immunodeficiency virus-1 (HIV-1) and inflammatory disorders.
tissue_expression_ns	hsa-mir-129	Sertoli Cell-Only Syndrome	28779347	reproductive system disease	DOID:0050457		D054331	305700		Among the highest differentially expressed miRNAs only seven, hsa-miR-34b, hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-449a, hsa-miR-449b*, hsa-miR-517b, and hsa-miR-129-3p, were shared by the three histopathological conditions and were strongly downregulated compared to the normal group 
tissue_expression_ns	hsa-mir-34b	Sertoli Cell-Only Syndrome	28779347	reproductive system disease	DOID:0050457		D054331	305700		Among the highest differentially expressed miRNAs only seven, hsa-miR-34b, hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-449a, hsa-miR-449b*, hsa-miR-517b, and hsa-miR-129-3p, were shared by the three histopathological conditions and were strongly downregulated compared to the normal group 
tissue_expression_ns	hsa-mir-34c	Sertoli Cell-Only Syndrome	28779347	reproductive system disease	DOID:0050457		D054331	305700		Among the highest differentially expressed miRNAs only seven, hsa-miR-34b, hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-449a, hsa-miR-449b*, hsa-miR-517b, and hsa-miR-129-3p, were shared by the three histopathological conditions and were strongly downregulated compared to the normal group 
tissue_expression_ns	hsa-mir-449a	Sertoli Cell-Only Syndrome	28779347	reproductive system disease	DOID:0050457		D054331	305700		Among the highest differentially expressed miRNAs only seven, hsa-miR-34b, hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-449a, hsa-miR-449b*, hsa-miR-517b, and hsa-miR-129-3p, were shared by the three histopathological conditions and were strongly downregulated compared to the normal group 
tissue_expression_ns	hsa-mir-449b	Sertoli Cell-Only Syndrome	28779347	reproductive system disease	DOID:0050457		D054331	305700		Among the highest differentially expressed miRNAs only seven, hsa-miR-34b, hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-449a, hsa-miR-449b*, hsa-miR-517b, and hsa-miR-129-3p, were shared by the three histopathological conditions and were strongly downregulated compared to the normal group 
tissue_expression_ns	hsa-mir-517b	Sertoli Cell-Only Syndrome	28779347	reproductive system disease	DOID:0050457		D054331	305700		Among the highest differentially expressed miRNAs only seven, hsa-miR-34b, hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-449a, hsa-miR-449b*, hsa-miR-517b, and hsa-miR-129-3p, were shared by the three histopathological conditions and were strongly downregulated compared to the normal group 
tissue_expression_ns	hsa-mir-182	Shock, Septic	22940033			R65.21	D012772			We confirmed expression of select miRNAs (miR-182, -199a-5p, -203, -211, -222, and -29b) using quantitative reverse transcriptase-polymerase chain reaction.
tissue_expression_ns	hsa-mir-199a	Shock, Septic	22940033			R65.21	D012772			We confirmed expression of select miRNAs (miR-182, -199a-5p, -203, -211, -222, and -29b) using quantitative reverse transcriptase-polymerase chain reaction.
tissue_expression_ns	hsa-mir-203	Shock, Septic	22940033			R65.21	D012772			We confirmed expression of select miRNAs (miR-182, -199a-5p, -203, -211, -222, and -29b) using quantitative reverse transcriptase-polymerase chain reaction.
tissue_expression_ns	hsa-mir-211	Shock, Septic	22940033			R65.21	D012772			We confirmed expression of select miRNAs (miR-182, -199a-5p, -203, -211, -222, and -29b) using quantitative reverse transcriptase-polymerase chain reaction.
tissue_expression_ns	hsa-mir-222	Shock, Septic	22940033			R65.21	D012772			We confirmed expression of select miRNAs (miR-182, -199a-5p, -203, -211, -222, and -29b) using quantitative reverse transcriptase-polymerase chain reaction.
tissue_expression_ns	hsa-mir-29b	Shock, Septic	22940033			R65.21	D012772			We confirmed expression of select miRNAs (miR-182, -199a-5p, -203, -211, -222, and -29b) using quantitative reverse transcriptase-polymerase chain reaction.
tissue_expression_ns	hsa-mir-181c	Silicosis	26903263	respiratory system disease	DOID:10325	J62.8	D012829			The differential expression of two selected miRNAs hsa-miR-181c-5p and hsa-miR-29a-3p were confirmed by RT-qPCR.
tissue_expression_ns	hsa-mir-29a	Silicosis	26903263	respiratory system disease	DOID:10325	J62.8	D012829			The differential expression of two selected miRNAs hsa-miR-181c-5p and hsa-miR-29a-3p were confirmed by RT-qPCR.
tissue_expression_ns	hsa-mir-146a	Sjogren Syndrome	28339495	immune system disease	DOID:12894	M35.00	D012859	270150		MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-148a	Sjogren Syndrome	28339495	immune system disease	DOID:12894	M35.00	D012859	270150		MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-150	Sjogren Syndrome	28339495	immune system disease	DOID:12894	M35.00	D012859	270150		MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-152	Sjogren Syndrome	28339495	immune system disease	DOID:12894	M35.00	D012859	270150		MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-155	Sjogren Syndrome	28339495	immune system disease	DOID:12894	M35.00	D012859	270150		MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-16	Sjogren Syndrome	28339495	immune system disease	DOID:12894	M35.00	D012859	270150		MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-21	Sjogren Syndrome	28339495	immune system disease	DOID:12894	M35.00	D012859	270150		MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-223	Sjogren Syndrome	28339495	immune system disease	DOID:12894	M35.00	D012859	270150		MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-224	Sjogren Syndrome	28339495	immune system disease	DOID:12894	M35.00	D012859	270150		MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-326	Sjogren Syndrome	28339495	immune system disease	DOID:12894	M35.00	D012859	270150		MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-342	Sjogren Syndrome	28339495	immune system disease	DOID:12894	M35.00	D012859	270150		MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-424	Skin Hemangioma	28928430	disease of cellular proliferation	DOID:471	D18.01				The expression and function of miR-424 in infantile skin hemangioma and its mechanism.
tissue_expression_ns	hsa-mir-1203	Small Cell Carcinoma, Esophageal	25667451							The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE.
tissue_expression_ns	hsa-mir-1249	Small Cell Carcinoma, Esophageal	25667451							The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE.
tissue_expression_ns	hsa-mir-3619	Small Cell Carcinoma, Esophageal	25667451							The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE.
tissue_expression_ns	hsa-mir-4419b	Small Cell Carcinoma, Esophageal	25667451							The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE.
tissue_expression_ns	hsa-mir-4648	Small Cell Carcinoma, Esophageal	25667451							The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE.
tissue_expression_ns	hsa-mir-4664	Small Cell Carcinoma, Esophageal	25667451							The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE.
tissue_expression_ns	hsa-mir-765	Soft Tissue Sarcoma	27223121			C49.9	D012509		HP:0030448	miR-765 could possibly be a diagnostic tool for ES because of its 97% specificity and 80% sensitivity.
tissue_expression_ns	hsa-mir-1237	Spinal Chordoma	25850393	musculoskeletal system disease	DOID:4153		D002817			The data from the current study identified a total of 29 differentially expressed miRNAs in chordoma tissues and reduced miR-1237-3p expression was associated with chordoma invasion and worse recurrence-free survival of the patients.
tissue_expression_ns	hsa-let-7a	Squamous Cell Carcinoma	27835588	disease of cellular proliferation	DOID:1749		D002294			Expressions of miR-30c and let-7a are inversely correlated with HMGA2 expression in squamous cell carcinoma of the vulva.
tissue_expression_ns	hsa-mir-101	Squamous Cell Carcinoma, Esophageal	25538231	disease of cellular proliferation	DOID:3748		C562729			A significant negative correlation exists between miR-101 or miR-217 and MALAT1 in 42 pairs of ESCC tissue samples and adjacent normal tissues. Mice xenograft data also support the tumor suppressor role of both miRNAs in ESCCs.
tissue_expression_ns	hsa-mir-106b	Squamous Cell Carcinoma, Esophageal	27998862	disease of cellular proliferation	DOID:3748		C562729			Expression of mir-106b in esophageal squamous cell carcinoma.
tissue_expression_ns	hsa-mir-10a	Squamous Cell Carcinoma, Esophageal	20588024	disease of cellular proliferation	DOID:3748		C562729			We found that miR-205 and miR-10a were significantly altered in cellular expression, and might be specific for ESCC with potential roles in the pathogenesis. 
tissue_expression_ns	hsa-mir-146b	Squamous Cell Carcinoma, Esophageal	23175214	disease of cellular proliferation	DOID:3748		C562729			The expression levels of miR-21 (p = 0.027), miR-181b (p = 0.002) and miR-146b (p = 0.021) in tumor tissue and miR-21 (p = 0.003) in noncancerous tissue were associated with overall survival of patients. 
tissue_expression_ns	hsa-mir-148	Squamous Cell Carcinoma, Esophageal	25928282	disease of cellular proliferation	DOID:3748		C562729			Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer.
tissue_expression_ns	hsa-mir-17	Squamous Cell Carcinoma, Esophageal	24360091	disease of cellular proliferation	DOID:3748		C562729			miR-17, miR-18a, and miR-19a can serve as potential unfavorable prognostic biomarkers in ESCC which are associated with some clinicopathologic factors
tissue_expression_ns	hsa-mir-181b	Squamous Cell Carcinoma, Esophageal	23175214	disease of cellular proliferation	DOID:3748		C562729			The expression levels of miR-21 (p = 0.027), miR-181b (p = 0.002) and miR-146b (p = 0.021) in tumor tissue and miR-21 (p = 0.003) in noncancerous tissue were associated with overall survival of patients. 
tissue_expression_ns	hsa-mir-181c	Squamous Cell Carcinoma, Esophageal	26888510	disease of cellular proliferation	DOID:3748		C562729			There are significant correlation between miR-181c-3p/miR-5692b expression, clinicopathologic parameters and prognosis. They represent potential prognostic biomarkers in esophageal squamous cell carcinoma.
tissue_expression_ns	hsa-mir-186	Squamous Cell Carcinoma, Esophageal	27889881	disease of cellular proliferation	DOID:3748		C562729			Identification of reference genes and miRNAs for qRT-PCR in human esophageal squamous cell carcinoma.
tissue_expression_ns	hsa-mir-18a	Squamous Cell Carcinoma, Esophageal	24360091	disease of cellular proliferation	DOID:3748		C562729			miR-17, miR-18a, and miR-19a can serve as potential unfavorable prognostic biomarkers in ESCC which are associated with some clinicopathologic factors
tissue_expression_ns	hsa-mir-19a	Squamous Cell Carcinoma, Esophageal	24360091	disease of cellular proliferation	DOID:3748		C562729			miR-17, miR-18a, and miR-19a can serve as potential unfavorable prognostic biomarkers in ESCC which are associated with some clinicopathologic factors
tissue_expression_ns	hsa-mir-203	Squamous Cell Carcinoma, Esophageal	25928282	disease of cellular proliferation	DOID:3748		C562729			Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer.
tissue_expression_ns	hsa-mir-205	Squamous Cell Carcinoma, Esophageal	20588024	disease of cellular proliferation	DOID:3748		C562729			We found that miR-205 and miR-10a were significantly altered in cellular expression, and might be specific for ESCC with potential roles in the pathogenesis. 
tissue_expression_ns	hsa-mir-21	Squamous Cell Carcinoma, Esophageal	25928282	disease of cellular proliferation	DOID:3748		C562729			Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer.
tissue_expression_ns	hsa-mir-21	Squamous Cell Carcinoma, Esophageal	23175214	disease of cellular proliferation	DOID:3748		C562729			The expression levels of miR-21 (p = 0.027), miR-181b (p = 0.002) and miR-146b (p = 0.021) in tumor tissue and miR-21 (p = 0.003) in noncancerous tissue were associated with overall survival of patients. 
tissue_expression_ns	hsa-mir-217	Squamous Cell Carcinoma, Esophageal	25538231	disease of cellular proliferation	DOID:3748		C562729			A significant negative correlation exists between miR-101 or miR-217 and MALAT1 in 42 pairs of ESCC tissue samples and adjacent normal tissues. Mice xenograft data also support the tumor suppressor role of both miRNAs in ESCCs.
tissue_expression_ns	hsa-mir-28	Squamous Cell Carcinoma, Esophageal	27889881	disease of cellular proliferation	DOID:3748		C562729			Identification of reference genes and miRNAs for qRT-PCR in human esophageal squamous cell carcinoma.
tissue_expression_ns	hsa-mir-29c	Squamous Cell Carcinoma, Esophageal	25928282	disease of cellular proliferation	DOID:3748		C562729			Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer.
tissue_expression_ns	hsa-mir-335	Squamous Cell Carcinoma, Esophageal	25337272	disease of cellular proliferation	DOID:3748		C562729			miR-335 expression isan independent prognostic factor for patients with esophageal cancer, which might be a potential valuable biomarker for ESCC.
tissue_expression_ns	hsa-mir-33b	Squamous Cell Carcinoma, Esophageal	27609581	disease of cellular proliferation	DOID:3748		C562729			The expression and significance of miR-33b and HMGA2 in esophageal squamous cell carcinoma.
tissue_expression_ns	hsa-mir-34a	Squamous Cell Carcinoma, Esophageal	27889881	disease of cellular proliferation	DOID:3748		C562729			Identification of reference genes and miRNAs for qRT-PCR in human esophageal squamous cell carcinoma.
tissue_expression_ns	hsa-mir-5692b	Squamous Cell Carcinoma, Esophageal	26888510	disease of cellular proliferation	DOID:3748		C562729			There are significant correlation between miR-181c-3p/miR-5692b expression, clinicopathologic parameters and prognosis. They represent potential prognostic biomarkers in esophageal squamous cell carcinoma.
tissue_expression_ns	hsa-mir-574	Squamous Cell Carcinoma, Esophageal	27565418	disease of cellular proliferation	DOID:3748		C562729			The expression of microRNA 574-3p as a predictor of postoperative outcome in patients with esophageal squamous cell carcinoma.
tissue_expression_ns	hsa-mir-638	Squamous Cell Carcinoma, Esophageal	28108314	disease of cellular proliferation	DOID:3748		C562729			MiRNA-638 promotes autophagy and malignant phenotypes of cancer cells via directly suppressing DACT3.
tissue_expression_ns	hsa-mir-10a	Squamous Cell Carcinoma, Head and Neck	28495058	disease of cellular proliferation	DOID:5520	C76.0	C535575			miRNA profiling of primary lung and head and neck squamous cell carcinomas: Addressing a diagnostic dilemma.
tissue_expression_ns	hsa-mir-10b	Squamous Cell Carcinoma, Head and Neck	28495058	disease of cellular proliferation	DOID:5520	C76.0	C535575			miRNA profiling of primary lung and head and neck squamous cell carcinomas: Addressing a diagnostic dilemma.
tissue_expression_ns	hsa-mir-155	Squamous Cell Carcinoma, Head and Neck	28347920	disease of cellular proliferation	DOID:5520	C76.0	C535575			MiR-200b and miR-155 as predictive biomarkers for the efficacy of chemoradiation in locally advanced head and neck squamous cell carcinoma.
tissue_expression_ns	hsa-mir-200b	Squamous Cell Carcinoma, Head and Neck	28347920	disease of cellular proliferation	DOID:5520	C76.0	C535575			MiR-200b and miR-155 as predictive biomarkers for the efficacy of chemoradiation in locally advanced head and neck squamous cell carcinoma.
tissue_expression_ns	hsa-mir-34a	Squamous Cell Carcinoma, Head and Neck	28495058	disease of cellular proliferation	DOID:5520	C76.0	C535575			miRNA profiling of primary lung and head and neck squamous cell carcinomas: Addressing a diagnostic dilemma.
tissue_expression_ns	hsa-mir-375	Squamous Cell Carcinoma, Head and Neck	27440205	disease of cellular proliferation	DOID:5520	C76.0	C535575			Primary HNSCC carcinoma tissues can be distinguished from histologically normal-matched noncancerous tumour-adjacent tissues based on hsa-miR-375-3p expression.
tissue_expression_ns	hsa-let-7a	Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal	29082244	disease of cellular proliferation	DOID:2876					Expression Levels and Clinical Significance of miR-21-5p, miR-let-7a, and miR-34c-5p in Laryngeal Squamous Cell Carcinoma.
tissue_expression_ns	hsa-mir-106b	Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal	25189575	disease of cellular proliferation	DOID:2876					Guo investigated regulation and expression of three miRNAs; miR-21, miR-106b and miR-375. The paper reported these miRNAs as potential biomarkers for laryngeal squamous cell carcinoma diagnosis.
tissue_expression_ns	hsa-mir-21	Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal	29082244	disease of cellular proliferation	DOID:2876					Expression Levels and Clinical Significance of miR-21-5p, miR-let-7a, and miR-34c-5p in Laryngeal Squamous Cell Carcinoma.
tissue_expression_ns	hsa-mir-23a	Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal	26175945	disease of cellular proliferation	DOID:2876					MiR-21/miR-375 ratio is an independent prognostic factor in patients with laryngeal squamous cell carcinoma.
tissue_expression_ns	hsa-mir-34c	Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal	29082244	disease of cellular proliferation	DOID:2876					Expression Levels and Clinical Significance of miR-21-5p, miR-let-7a, and miR-34c-5p in Laryngeal Squamous Cell Carcinoma.
tissue_expression_ns	hsa-mir-140	Squamous Cell Carcinoma, Lung	21890451	disease of cellular proliferation	DOID:3907	C34.91				The authors identified a five-microRNA classifier (hsa-miR-210, hsa-miR-182, hsa-miR-486-5p, hsa-miR-30a and hsa-miR-140-3p) that could distinguish SCC (Squamous cell carcinoma) from normal lung tissues.
tissue_expression_ns	hsa-mir-182	Squamous Cell Carcinoma, Lung	21890451	disease of cellular proliferation	DOID:3907	C34.91				The authors identified a five-microRNA classifier (hsa-miR-210, hsa-miR-182, hsa-miR-486-5p, hsa-miR-30a and hsa-miR-140-3p) that could distinguish SCC (Squamous cell carcinoma) from normal lung tissues.
tissue_expression_ns	hsa-mir-182	Squamous Cell Carcinoma, Lung	24600991	disease of cellular proliferation	DOID:3907	C34.91				We provide first time evidence through tissue microarray and quantitative PCR validation of mir-182 in the expression of lung squamous cell carcinoma. Our data provide a possible mechanism for lung cancer cell proliferation in lung squamous cell cancer and may be helpful in discovering a new strategy to reveal lung squamous cell carcinoma progress.
tissue_expression_ns	hsa-mir-196a	Squamous Cell Carcinoma, Lung	23074073	disease of cellular proliferation	DOID:3907	C34.91				Validation of selected microRNAs by in situ hybridization demonstrated strong expression of hsa-miR-196a in the inner tumor; moderate expression of hsa-miR-224 in the inner tumor and tumor front, and strong expression of hsa-miR-650 in the adjacent lung tissue.
tissue_expression_ns	hsa-mir-210	Squamous Cell Carcinoma, Lung	21890451	disease of cellular proliferation	DOID:3907	C34.91				The authors identified a five-microRNA classifier (hsa-miR-210, hsa-miR-182, hsa-miR-486-5p, hsa-miR-30a and hsa-miR-140-3p) that could distinguish SCC (Squamous cell carcinoma) from normal lung tissues.
tissue_expression_ns	hsa-mir-224	Squamous Cell Carcinoma, Lung	23074073	disease of cellular proliferation	DOID:3907	C34.91				Validation of selected microRNAs by in situ hybridization demonstrated strong expression of hsa-miR-196a in the inner tumor; moderate expression of hsa-miR-224 in the inner tumor and tumor front, and strong expression of hsa-miR-650 in the adjacent lung tissue.
tissue_expression_ns	hsa-mir-30a	Squamous Cell Carcinoma, Lung	21890451	disease of cellular proliferation	DOID:3907	C34.91				The authors identified a five-microRNA classifier (hsa-miR-210, hsa-miR-182, hsa-miR-486-5p, hsa-miR-30a and hsa-miR-140-3p) that could distinguish SCC (Squamous cell carcinoma) from normal lung tissues.
tissue_expression_ns	hsa-mir-486	Squamous Cell Carcinoma, Lung	21890451	disease of cellular proliferation	DOID:3907	C34.91				The authors identified a five-microRNA classifier (hsa-miR-210, hsa-miR-182, hsa-miR-486-5p, hsa-miR-30a and hsa-miR-140-3p) that could distinguish SCC (Squamous cell carcinoma) from normal lung tissues.
tissue_expression_ns	hsa-mir-650	Squamous Cell Carcinoma, Lung	23074073	disease of cellular proliferation	DOID:3907	C34.91				Validation of selected microRNAs by in situ hybridization demonstrated strong expression of hsa-miR-196a in the inner tumor; moderate expression of hsa-miR-224 in the inner tumor and tumor front, and strong expression of hsa-miR-650 in the adjacent lung tissue.
tissue_expression_ns	hsa-let-7g	Squamous Cell Carcinoma, Oral	25050621	disease of cellular proliferation	DOID:0050866					MicroRNAs MiR-218, MiR-125b, and Let-7g predict prognosis in patients with oral cavity squamous cell carcinoma.
tissue_expression_ns	hsa-mir-125b	Squamous Cell Carcinoma, Oral	25050621	disease of cellular proliferation	DOID:0050866					MicroRNAs MiR-218, MiR-125b, and Let-7g predict prognosis in patients with oral cavity squamous cell carcinoma.
tissue_expression_ns	hsa-mir-125b	Squamous Cell Carcinoma, Oral	27935034	disease of cellular proliferation	DOID:0050866					Integrated Analysis and MicroRNA Expression Profiling Identified Seven miRNAs Associated With Progression of Oral Squamous Cell Carcinoma.
tissue_expression_ns	hsa-mir-1275	Squamous Cell Carcinoma, Oral	27056547	disease of cellular proliferation	DOID:0050866					the expression of miR-1275 was variable in tumours, with high levels associated to regional lymph node invasion;
tissue_expression_ns	hsa-mir-133a	Squamous Cell Carcinoma, Oral	27935034	disease of cellular proliferation	DOID:0050866					Integrated Analysis and MicroRNA Expression Profiling Identified Seven miRNAs Associated With Progression of Oral Squamous Cell Carcinoma.
tissue_expression_ns	hsa-mir-133b	Squamous Cell Carcinoma, Oral	27935034	disease of cellular proliferation	DOID:0050866					Integrated Analysis and MicroRNA Expression Profiling Identified Seven miRNAs Associated With Progression of Oral Squamous Cell Carcinoma.
tissue_expression_ns	hsa-mir-139	Squamous Cell Carcinoma, Oral	27935034	disease of cellular proliferation	DOID:0050866					Integrated Analysis and MicroRNA Expression Profiling Identified Seven miRNAs Associated With Progression of Oral Squamous Cell Carcinoma.
tissue_expression_ns	hsa-mir-184	Squamous Cell Carcinoma, Oral	25482863	disease of cellular proliferation	DOID:0050866					Our results corroborate the previous findings on the overexpression  of mir-21 and downregulation of miR-138 in OSCC. As the expression of miR-184 is controversial in tongue/oral cancer, the downregulation may be specific to tumor anatomical localization. On the other hand, to the best of our knowledge, this is the first report to show the association of miR-155 with tobacco chewing and the downregulation of miR-125b-2* in OSCC. Computational predictions suggest that miR-125b-2* may have a role in alternative splicing.
tissue_expression_ns	hsa-mir-200	Squamous Cell Carcinoma, Oral	29375721	disease of cellular proliferation	DOID:0050866					Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma
tissue_expression_ns	hsa-mir-21	Squamous Cell Carcinoma, Oral	24755828	disease of cellular proliferation	DOID:0050866					MiR-21 expression in the tumor stroma of oral squamous cell carcinoma: an independent biomarker of disease free survival.
tissue_expression_ns	hsa-mir-21	Squamous Cell Carcinoma, Oral	27935034	disease of cellular proliferation	DOID:0050866					Integrated Analysis and MicroRNA Expression Profiling Identified Seven miRNAs Associated With Progression of Oral Squamous Cell Carcinoma.
tissue_expression_ns	hsa-mir-218	Squamous Cell Carcinoma, Oral	25050621	disease of cellular proliferation	DOID:0050866					MicroRNAs MiR-218, MiR-125b, and Let-7g predict prognosis in patients with oral cavity squamous cell carcinoma.
tissue_expression_ns	hsa-mir-31	Squamous Cell Carcinoma, Oral	26104160	disease of cellular proliferation	DOID:0050866					MiR-31 and miR-130b, known to inhibit several steps in the metastatic process, were over-expressed in non-metastatic samples and the expression of miR-130b was confirmed in plasma of patients showing no metastasis.
tissue_expression_ns	hsa-mir-31	Squamous Cell Carcinoma, Oral	27935034	disease of cellular proliferation	DOID:0050866					Integrated Analysis and MicroRNA Expression Profiling Identified Seven miRNAs Associated With Progression of Oral Squamous Cell Carcinoma.
tissue_expression_ns	hsa-mir-338	Squamous Cell Carcinoma, Oral	27935034	disease of cellular proliferation	DOID:0050866					Integrated Analysis and MicroRNA Expression Profiling Identified Seven miRNAs Associated With Progression of Oral Squamous Cell Carcinoma.
tissue_expression_ns	hsa-mir-542	Squamous Cell Carcinoma, Oral	28275798	disease of cellular proliferation	DOID:0050866					Expression and correlation of survivin and hsa-miR-542-3p in patients with oral squamous cell carcinoma.
tissue_expression_ns	hsa-mir-200c	Squamous Cell Carcinoma, Sinonasal	28960576							Deregulation of selected microRNAs in sinonasal carcinoma: Value of miR-21 as prognostic biomarker in sinonasal squamous cell carcinoma.
tissue_expression_ns	hsa-mir-21	Squamous Cell Carcinoma, Sinonasal	28960576							Deregulation of selected microRNAs in sinonasal carcinoma: Value of miR-21 as prognostic biomarker in sinonasal squamous cell carcinoma.
tissue_expression_ns	hsa-mir-203	Squamous Cell Carcinoma, Skin or Unspecific	27943259	disease of cellular proliferation	DOID:3151	C44.92			HP:0006739	MicroRNA (miR)-203 and miR-205 expression patterns identify subgroups of prognosis in cutaneous squamous cell carcinoma.
tissue_expression_ns	hsa-mir-205	Squamous Cell Carcinoma, Skin or Unspecific	27943259	disease of cellular proliferation	DOID:3151	C44.92			HP:0006739	MicroRNA (miR)-203 and miR-205 expression patterns identify subgroups of prognosis in cutaneous squamous cell carcinoma.
tissue_expression_ns	hsa-mir-375	Squamous Cell Carcinoma, Tongue	25633534	disease of cellular proliferation	DOID:0050865	C02.9				miR-375 inhibits the cell growth, and its expression is correlated  with clinical outcomes in TSCC.
tissue_expression_ns	hsa-mir-498	Squamous Cell Carcinoma, Tongue	27773646	disease of cellular proliferation	DOID:0050865	C02.9				MicroRNA and protein profiles in invasive versus non-invasive oral tongue squamous cell carcinoma cells in vitro.
tissue_expression_ns	hsa-mir-940	Squamous Cell Carcinoma, Tongue	27773646	disease of cellular proliferation	DOID:0050865	C02.9				MicroRNA and protein profiles in invasive versus non-invasive oral tongue squamous cell carcinoma cells in vitro.
tissue_expression_ns	hsa-mir-155	Stroke	26663183			I64	D020521	601367	HP:0001297	we will provide insight into recent knowledge from animal and human studies concerning miRNA profiling in acute stroke and their expression dynamics in brain tissue and extracellular fluids (roles of, e.g. let-7 family, miR-21, miR-29 family, miR-124, miR-145, miR-181 family, miR-210 and miR-223)
tissue_expression_ns	hsa-mir-124	Stroke, Hemorrhagic	24650689			I61.9			HP:0001342	Both miR-124-3p and miR-16 are diagnostic markers to discriminate HS and IS.
tissue_expression_ns	hsa-mir-16	Stroke, Hemorrhagic	24650689			I61.9			HP:0001342	Both miR-124-3p and miR-16 are diagnostic markers to discriminate HS and IS.
tissue_expression_ns	hsa-mir-210	Stroke, Ischemic	27906445			I63.9			HP:0002140	The expression research of miR-210 in the elderly patients with COPD combined with ischemic stroke.
tissue_expression_ns	hsa-mir-146a	Systemic Lupus Erythematosus	28339495	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-148a	Systemic Lupus Erythematosus	28339495	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-150	Systemic Lupus Erythematosus	28339495	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-152	Systemic Lupus Erythematosus	28339495	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-155	Systemic Lupus Erythematosus	28339495	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-16	Systemic Lupus Erythematosus	28339495	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-21	Systemic Lupus Erythematosus	28339495	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-223	Systemic Lupus Erythematosus	28339495	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-224	Systemic Lupus Erythematosus	28339495	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-326	Systemic Lupus Erythematosus	28339495	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-342	Systemic Lupus Erythematosus	28339495	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome.
tissue_expression_ns	hsa-mir-140	Thymoma	28517980	disease of cellular proliferation	DOID:3275		D013945	274230	HP:0100522	Among the seven significant miRNAs, six (mir-140, mir-450b, mir-542, mir-639, mir-3613 and mir-3913–1) were positively associated with OS, while the remaining one (mir-1976) was negatively correlated
tissue_expression_ns	hsa-mir-1976	Thymoma	28517980	disease of cellular proliferation	DOID:3275		D013945	274230	HP:0100522	Among the seven significant miRNAs, six (mir-140, mir-450b, mir-542, mir-639, mir-3613 and mir-3913–1) were positively associated with OS, while the remaining one (mir-1976) was negatively correlated
tissue_expression_ns	hsa-mir-3613	Thymoma	28517980	disease of cellular proliferation	DOID:3275		D013945	274230	HP:0100522	Among the seven significant miRNAs, six (mir-140, mir-450b, mir-542, mir-639, mir-3613 and mir-3913–1) were positively associated with OS, while the remaining one (mir-1976) was negatively correlated
tissue_expression_ns	hsa-mir-3913	Thymoma	28517980	disease of cellular proliferation	DOID:3275		D013945	274230	HP:0100522	Among the seven significant miRNAs, six (mir-140, mir-450b, mir-542, mir-639, mir-3613 and mir-3913–1) were positively associated with OS, while the remaining one (mir-1976) was negatively correlated
tissue_expression_ns	hsa-mir-450b	Thymoma	28517980	disease of cellular proliferation	DOID:3275		D013945	274230	HP:0100522	Among the seven significant miRNAs, six (mir-140, mir-450b, mir-542, mir-639, mir-3613 and mir-3913–1) were positively associated with OS, while the remaining one (mir-1976) was negatively correlated
tissue_expression_ns	hsa-mir-542	Thymoma	28517980	disease of cellular proliferation	DOID:3275		D013945	274230	HP:0100522	Among the seven significant miRNAs, six (mir-140, mir-450b, mir-542, mir-639, mir-3613 and mir-3913–1) were positively associated with OS, while the remaining one (mir-1976) was negatively correlated
tissue_expression_ns	hsa-mir-639	Thymoma	28517980	disease of cellular proliferation	DOID:3275		D013945	274230	HP:0100522	Among the seven significant miRNAs, six (mir-140, mir-450b, mir-542, mir-639, mir-3613 and mir-3913–1) were positively associated with OS, while the remaining one (mir-1976) was negatively correlated
tissue_expression_ns	hsa-mir-146b	Thyroid Lymphoma	24327568	disease of cellular proliferation	DOID:10011	C85.99				Histotype-specific miRNA signatures can provide new insight into the molecular mechanisms of thyroid carcinogenesis. The tested 4-miRNA signature is a promising diagnostic tool for differentiating ATC from PTL and non-neoplastic MNG, even in the presence of scant material obtained from minimally invasive procedures.
tissue_expression_ns	hsa-mir-221	Thyroid Lymphoma	24327568	disease of cellular proliferation	DOID:10011	C85.99				Histotype-specific miRNA signatures can provide new insight into the molecular mechanisms of thyroid carcinogenesis. The tested 4-miRNA signature is a promising diagnostic tool for differentiating ATC from PTL and non-neoplastic MNG, even in the presence of scant material obtained from minimally invasive procedures.
tissue_expression_ns	hsa-mir-222	Thyroid Lymphoma	24327568	disease of cellular proliferation	DOID:10011	C85.99				Histotype-specific miRNA signatures can provide new insight into the molecular mechanisms of thyroid carcinogenesis. The tested 4-miRNA signature is a promising diagnostic tool for differentiating ATC from PTL and non-neoplastic MNG, even in the presence of scant material obtained from minimally invasive procedures.
tissue_expression_ns	hsa-mir-26a	Thyroid Lymphoma	24327568	disease of cellular proliferation	DOID:10011	C85.99				Histotype-specific miRNA signatures can provide new insight into the molecular mechanisms of thyroid carcinogenesis. The tested 4-miRNA signature is a promising diagnostic tool for differentiating ATC from PTL and non-neoplastic MNG, even in the presence of scant material obtained from minimally invasive procedures.
tissue_expression_ns	hsa-mir-138	Thyroid Neoplasms	27547222	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	Expression of miRNA and Occurrence of Distant Metastases in Patients with Hürthle Cell Carcinoma.
tissue_expression_ns	hsa-let-7b	Thyroid Neoplasms	29762469	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	The expression of miRNAs hsa-let-7f-5p, has-let-7b-5p hsa-miR-146b-5p and hsa-miR-146b-3p was modulated heterogeneously
tissue_expression_ns	hsa-let-7f	Thyroid Neoplasms	29762469	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	The expression of miRNAs hsa-let-7f-5p, has-let-7b-5p hsa-miR-146b-5p and hsa-miR-146b-3p was modulated heterogeneously
tissue_expression_ns	hsa-mir-146b	Thyroid Neoplasms	29762469	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	The expression of miRNAs hsa-let-7f-5p, has-let-7b-5p hsa-miR-146b-5p and hsa-miR-146b-3p was modulated heterogeneously
tissue_expression_ns	hsa-mir-146b	Thyroid Neoplasms	21778212	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	In this context, a small set of miRNAs (i.e. miR-7, miR-146a, miR-146b, miR-200b, miR-221, and miR-222) appears to be useful, though not sufficient per se, in distinguishing TT-UMP from other WDT of the thyroid gland.
tissue_expression_ns	hsa-mir-200b	Thyroid Neoplasms	21778212	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	In this context, a small set of miRNAs (i.e. miR-7, miR-146a, miR-146b, miR-200b, miR-221, and miR-222) appears to be useful, though not sufficient per se, in distinguishing TT-UMP from other WDT of the thyroid gland.
tissue_expression_ns	hsa-mir-221	Thyroid Neoplasms	21778212	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	In this context, a small set of miRNAs (i.e. miR-7, miR-146a, miR-146b, miR-200b, miR-221, and miR-222) appears to be useful, though not sufficient per se, in distinguishing TT-UMP from other WDT of the thyroid gland.
tissue_expression_ns	hsa-mir-222	Thyroid Neoplasms	21778212	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	In this context, a small set of miRNAs (i.e. miR-7, miR-146a, miR-146b, miR-200b, miR-221, and miR-222) appears to be useful, though not sufficient per se, in distinguishing TT-UMP from other WDT of the thyroid gland.
tissue_expression_ns	hsa-mir-7	Thyroid Neoplasms	21778212	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	In this context, a small set of miRNAs (i.e. miR-7, miR-146a, miR-146b, miR-200b, miR-221, and miR-222) appears to be useful, though not sufficient per se, in distinguishing TT-UMP from other WDT of the thyroid gland.
tissue_expression_ns	hsa-mir-20a	Toxoplasma gondii Infection	28424428	disease by infectious agent	DOID:9965	B58	D014123			Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection.
tissue_expression_ns	hsa-mir-126	Traumatic Brain Injury	27027233			S06.2	D000070642			Our results indicated that altered expression of miR-126-3p and miR-3610 may play an important role in the development of TBI-induced hypopituitarism.
tissue_expression_ns	hsa-mir-150	Traumatic Brain Injury	24108763			S06.2	D000070642			neutrophils associated with traumatic injury were found to have a unique miRNA signature. Changes in signaling pathways due to deregulated miRNAs may be involved in the pathological processes of traumatic injury.
tissue_expression_ns	hsa-mir-155	Traumatic Brain Injury	24108763			S06.2	D000070642			neutrophils associated with traumatic injury were found to have a unique miRNA signature. Changes in signaling pathways due to deregulated miRNAs may be involved in the pathological processes of traumatic injury.
tissue_expression_ns	hsa-mir-223	Traumatic Brain Injury	24108763			S06.2	D000070642			neutrophils associated with traumatic injury were found to have a unique miRNA signature. Changes in signaling pathways due to deregulated miRNAs may be involved in the pathological processes of traumatic injury.
tissue_expression_ns	hsa-mir-23a	Traumatic Brain Injury	24108763			S06.2	D000070642			neutrophils associated with traumatic injury were found to have a unique miRNA signature. Changes in signaling pathways due to deregulated miRNAs may be involved in the pathological processes of traumatic injury.
tissue_expression_ns	hsa-mir-30e	Traumatic Brain Injury	24108763			S06.2	D000070642			neutrophils associated with traumatic injury were found to have a unique miRNA signature. Changes in signaling pathways due to deregulated miRNAs may be involved in the pathological processes of traumatic injury.
tissue_expression_ns	hsa-mir-3610	Traumatic Brain Injury	27027233			S06.2	D000070642			Our results indicated that altered expression of miR-126-3p and miR-3610 may play an important role in the development of TBI-induced hypopituitarism.
tissue_expression_ns	hsa-mir-3945	Traumatic Brain Injury	24108763			S06.2	D000070642			neutrophils associated with traumatic injury were found to have a unique miRNA signature. Changes in signaling pathways due to deregulated miRNAs may be involved in the pathological processes of traumatic injury.
tissue_expression_ns	hsa-mir-196	Tuberculosis	27102525	disease by infectious agent	DOID:399	A15-A19	D014376			9鈥塵iRNAs were differentially expressed after MAP infection.
tissue_expression_ns	hsa-mir-196b	Tuberculosis	24586438	disease by infectious agent	DOID:399	A15-A19	D014376			The microRNA differential-expression profiles generated in this study provide a good foundation for the development of markers for TB diagnosis, and for investigations on the role of microRNAs in BCG-inoculated and latent-infected individuals.
tissue_expression_ns	hsa-mir-376c	Tuberculosis	24586438	disease by infectious agent	DOID:399	A15-A19	D014376			The microRNA differential-expression profiles generated in this study provide a good foundation for the development of markers for TB diagnosis, and for investigations on the role of microRNAs in BCG-inoculated and latent-infected individuals.
tissue_expression_ns	hsa-mir-130b	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-130b*: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-144	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-144: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-155	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-155: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-181b-1	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-181b: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-181b-2	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-181b: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-21	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-21*: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-223	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-223: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-302a	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-302a: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-329-1	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-329: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-329-2	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-329: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-342	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-342-5p: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-421	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-421: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-424	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-424: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-451a	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-451: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-486	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-486-5p: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-520d	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-520d-3p: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-548b	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-548b-3p: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-550a-1	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-550*: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-550a-2	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-550*: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-550a-3	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-550*: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-550b-1	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-550*: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-550b-2	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-550*: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-640	Tuberculosis, Pulmonary	22003408	disease by infectious agent	DOID:2957	A15	D014397			hsa-mir-640: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI).
tissue_expression_ns	hsa-mir-100	Urinary Bladder Cancer	22644299	urinary system disease	DOID:11054	C67	D001749	109800		differential expression in urinary samples
tissue_expression_ns	hsa-mir-100	Urinary Bladder Cancer	22330141	urinary system disease	DOID:11054	C67	D001749	109800		Altered expression of five significantly differentially expressed miRNAs, hsa-miR-9 (1q23.2), hsa-miR-15b (3q25.32), hsa-miR-28-5p (3q27.3), hsa-miR-100 and hsa-miR-125b (both 11q24.1), was directly linked to frequent chromosomal alterations.
tissue_expression_ns	hsa-mir-10a	Urinary Bladder Cancer	24439061	urinary system disease	DOID:11054	C67	D001749	109800		The role of microRNA profiling in prognosticating progression in Ta and T1 urinary bladder cancer.
tissue_expression_ns	hsa-mir-10a	Urinary Bladder Cancer	22140553	urinary system disease	DOID:11054	C67	D001749	109800		deregulated
tissue_expression_ns	hsa-mir-10a	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-1-1	Urinary Bladder Cancer	21133599	urinary system disease	DOID:11054	C67	D001749	109800		dysregulated
tissue_expression_ns	hsa-mir-1-1	Urinary Bladder Cancer	22140553	urinary system disease	DOID:11054	C67	D001749	109800		deregulated
tissue_expression_ns	hsa-mir-1-2	Urinary Bladder Cancer	21133599	urinary system disease	DOID:11054	C67	D001749	109800		dysregulated
tissue_expression_ns	hsa-mir-1-2	Urinary Bladder Cancer	22140553	urinary system disease	DOID:11054	C67	D001749	109800		deregulated
tissue_expression_ns	hsa-mir-1224	Urinary Bladder Cancer	22644299	urinary system disease	DOID:11054	C67	D001749	109800		differential expression in urinary samples
tissue_expression_ns	hsa-mir-125b-1	Urinary Bladder Cancer	21133599	urinary system disease	DOID:11054	C67	D001749	109800		dysregulated
tissue_expression_ns	hsa-mir-125b-1	Urinary Bladder Cancer	22140553	urinary system disease	DOID:11054	C67	D001749	109800		deregulated
tissue_expression_ns	hsa-mir-125b-1	Urinary Bladder Cancer	22330141	urinary system disease	DOID:11054	C67	D001749	109800		Altered expression of five significantly differentially expressed miRNAs, hsa-miR-9 (1q23.2), hsa-miR-15b (3q25.32), hsa-miR-28-5p (3q27.3), hsa-miR-100 and hsa-miR-125b (both 11q24.1), was directly linked to frequent chromosomal alterations.
tissue_expression_ns	hsa-mir-125b-2	Urinary Bladder Cancer	21133599	urinary system disease	DOID:11054	C67	D001749	109800		dysregulated
tissue_expression_ns	hsa-mir-125b-2	Urinary Bladder Cancer	22140553	urinary system disease	DOID:11054	C67	D001749	109800		deregulated
tissue_expression_ns	hsa-mir-133a-1	Urinary Bladder Cancer	21133599	urinary system disease	DOID:11054	C67	D001749	109800		dysregulated
tissue_expression_ns	hsa-mir-133a-1	Urinary Bladder Cancer	22140553	urinary system disease	DOID:11054	C67	D001749	109800		deregulated
tissue_expression_ns	hsa-mir-133a-2	Urinary Bladder Cancer	21133599	urinary system disease	DOID:11054	C67	D001749	109800		dysregulated
tissue_expression_ns	hsa-mir-133a-2	Urinary Bladder Cancer	22140553	urinary system disease	DOID:11054	C67	D001749	109800		deregulated
tissue_expression_ns	hsa-mir-133b	Urinary Bladder Cancer	21133599	urinary system disease	DOID:11054	C67	D001749	109800		dysregulated
tissue_expression_ns	hsa-mir-133b	Urinary Bladder Cancer	22140553	urinary system disease	DOID:11054	C67	D001749	109800		deregulated
tissue_expression_ns	hsa-mir-135b	Urinary Bladder Cancer	22644299	urinary system disease	DOID:11054	C67	D001749	109800		differential expression in urinary samples
tissue_expression_ns	hsa-mir-143	Urinary Bladder Cancer	21133599	urinary system disease	DOID:11054	C67	D001749	109800		dysregulated
tissue_expression_ns	hsa-mir-143	Urinary Bladder Cancer	22140553	urinary system disease	DOID:11054	C67	D001749	109800		deregulated
tissue_expression_ns	hsa-mir-143	Urinary Bladder Cancer	22426337	urinary system disease	DOID:11054	C67	D001749	109800		miR-143, miR-222, and miR-452 Are Useful as Tumor Stratification and Noninvasive Diagnostic Biomarkers for Bladder Cancer.
tissue_expression_ns	hsa-mir-145	Urinary Bladder Cancer	21133599	urinary system disease	DOID:11054	C67	D001749	109800		dysregulated
tissue_expression_ns	hsa-mir-145	Urinary Bladder Cancer	22140553	urinary system disease	DOID:11054	C67	D001749	109800		deregulated
tissue_expression_ns	hsa-mir-146a	Urinary Bladder Cancer	23749909	urinary system disease	DOID:11054	C67	D001749	109800		altered expression
tissue_expression_ns	hsa-mir-155	Urinary Bladder Cancer	23749909	urinary system disease	DOID:11054	C67	D001749	109800		altered expression
tissue_expression_ns	hsa-mir-15a	Urinary Bladder Cancer	22644299	urinary system disease	DOID:11054	C67	D001749	109800		differential expression in urinary samples
tissue_expression_ns	hsa-mir-15b	Urinary Bladder Cancer	22644299	urinary system disease	DOID:11054	C67	D001749	109800		differential expression in urinary samples
tissue_expression_ns	hsa-mir-15b	Urinary Bladder Cancer	22330141	urinary system disease	DOID:11054	C67	D001749	109800		Altered expression of five significantly differentially expressed miRNAs, hsa-miR-9 (1q23.2), hsa-miR-15b (3q25.32), hsa-miR-28-5p (3q27.3), hsa-miR-100 and hsa-miR-125b (both 11q24.1), was directly linked to frequent chromosomal alterations.
tissue_expression_ns	hsa-mir-182	Urinary Bladder Cancer	22140553	urinary system disease	DOID:11054	C67	D001749	109800		deregulated
tissue_expression_ns	hsa-mir-183	Urinary Bladder Cancer	22140553	urinary system disease	DOID:11054	C67	D001749	109800		deregulated
tissue_expression_ns	hsa-mir-193b	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-196a-1	Urinary Bladder Cancer	23749909	urinary system disease	DOID:11054	C67	D001749	109800		altered expression
tissue_expression_ns	hsa-mir-196a-2	Urinary Bladder Cancer	23749909	urinary system disease	DOID:11054	C67	D001749	109800		altered expression
tissue_expression_ns	hsa-mir-200b	Urinary Bladder Cancer	21133599	urinary system disease	DOID:11054	C67	D001749	109800		dysregulated
tissue_expression_ns	hsa-mir-203	Urinary Bladder Cancer	22140553	urinary system disease	DOID:11054	C67	D001749	109800		deregulated
tissue_expression_ns	hsa-mir-203	Urinary Bladder Cancer	22644299	urinary system disease	DOID:11054	C67	D001749	109800		differential expression in urinary samples
tissue_expression_ns	hsa-mir-203	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-203	Urinary Bladder Cancer	23749909	urinary system disease	DOID:11054	C67	D001749	109800		altered expression
tissue_expression_ns	hsa-mir-20b	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-21	Urinary Bladder Cancer	23749909	urinary system disease	DOID:11054	C67	D001749	109800		altered expression
tissue_expression_ns	hsa-mir-212	Urinary Bladder Cancer	22644299	urinary system disease	DOID:11054	C67	D001749	109800		differential expression in urinary samples
tissue_expression_ns	hsa-mir-221	Urinary Bladder Cancer	23749909	urinary system disease	DOID:11054	C67	D001749	109800		altered expression
tissue_expression_ns	hsa-mir-222	Urinary Bladder Cancer	22426337	urinary system disease	DOID:11054	C67	D001749	109800		miR-143, miR-222, and miR-452 Are Useful as Tumor Stratification and Noninvasive Diagnostic Biomarkers for Bladder Cancer.
tissue_expression_ns	hsa-mir-224	Urinary Bladder Cancer	22140553	urinary system disease	DOID:11054	C67	D001749	109800		deregulated
tissue_expression_ns	hsa-mir-24-1	Urinary Bladder Cancer	22644299	urinary system disease	DOID:11054	C67	D001749	109800		differential expression in urinary samples
tissue_expression_ns	hsa-mir-27a	Urinary Bladder Cancer	23749909	urinary system disease	DOID:11054	C67	D001749	109800		altered expression
tissue_expression_ns	hsa-mir-27b	Urinary Bladder Cancer	22644299	urinary system disease	DOID:11054	C67	D001749	109800		differential expression in urinary samples
tissue_expression_ns	hsa-mir-28	Urinary Bladder Cancer	22330141	urinary system disease	DOID:11054	C67	D001749	109800		Altered expression of five significantly differentially expressed miRNAs, hsa-miR-9 (1q23.2), hsa-miR-15b (3q25.32), hsa-miR-28-5p (3q27.3), hsa-miR-100 and hsa-miR-125b (both 11q24.1), was directly linked to frequent chromosomal alterations.
tissue_expression_ns	hsa-mir-31	Urinary Bladder Cancer	24439061	urinary system disease	DOID:11054	C67	D001749	109800		The role of microRNA profiling in prognosticating progression in Ta and T1 urinary bladder cancer.
tissue_expression_ns	hsa-mir-328	Urinary Bladder Cancer	22644299	urinary system disease	DOID:11054	C67	D001749	109800		differential expression in urinary samples
tissue_expression_ns	hsa-mir-338	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-345	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-34a	Urinary Bladder Cancer	23749909	urinary system disease	DOID:11054	C67	D001749	109800		altered expression
tissue_expression_ns	hsa-mir-34b	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-34c	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-424	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-452	Urinary Bladder Cancer	22426337	urinary system disease	DOID:11054	C67	D001749	109800		miR-143, miR-222, and miR-452 Are Useful as Tumor Stratification and Noninvasive Diagnostic Biomarkers for Bladder Cancer.
tissue_expression_ns	hsa-mir-512-1	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-512-2	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-518a-1	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-518a-2	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-708	Urinary Bladder Cancer	21133599	urinary system disease	DOID:11054	C67	D001749	109800		dysregulated
tissue_expression_ns	hsa-mir-9-1	Urinary Bladder Cancer	22330141	urinary system disease	DOID:11054	C67	D001749	109800		Altered expression of five significantly differentially expressed miRNAs, hsa-miR-9 (1q23.2), hsa-miR-15b (3q25.32), hsa-miR-28-5p (3q27.3), hsa-miR-100 and hsa-miR-125b (both 11q24.1), was directly linked to frequent chromosomal alterations.
tissue_expression_ns	hsa-mir-9-1	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-9-2	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-9-3	Urinary Bladder Cancer	22801550	urinary system disease	DOID:11054	C67	D001749	109800		differentially expressed
tissue_expression_ns	hsa-mir-99a	Urinary Bladder Cancer	21133599	urinary system disease	DOID:11054	C67	D001749	109800		dysregulated
tissue_expression_ns	hsa-mir-99b	Urinary Bladder Cancer	21133599	urinary system disease	DOID:11054	C67	D001749	109800		dysregulated
tissue_expression_ns	hsa-mir-142	Uterine Corpus Endometrial Carcinoma	29567372	disease of cellular proliferation	DOID:0050939					A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma.
tissue_expression_ns	hsa-mir-146a	Uterine Corpus Endometrial Carcinoma	29567372	disease of cellular proliferation	DOID:0050939					A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma.
tissue_expression_ns	hsa-mir-15a	Uterine Corpus Endometrial Carcinoma	29567372	disease of cellular proliferation	DOID:0050939					A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma.
tissue_expression_ns	hsa-mir-1976	Uterine Corpus Endometrial Carcinoma	29567372	disease of cellular proliferation	DOID:0050939					A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma.
tissue_expression_ns	hsa-mir-3170	Uterine Corpus Endometrial Carcinoma	29567372	disease of cellular proliferation	DOID:0050939					A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma.
tissue_expression_ns	hsa-mir-200c	Uterine Corpus Myxoid Leiomyosarcoma	26307392	disease of cellular proliferation	DOID:6567					Malignant tumors of the uterine corpus: molecular background of their origin.
tissue_expression_ns	hsa-mir-21	Uterine Corpus Serous Adenocarcinoma	24748979	disease of cellular proliferation	DOID:5750					microRNA expression patterns across seven cancers are highly correlated and dominated by evolutionarily ancient families.
tissue_expression_ns	hsa-mir-146a	Uveal Melanoma	27565163				C536494	155720	HP:0007716	Expression of natural killer cell regulatory microRNA by uveal melanoma cancer stem cells.
tissue_expression_ns	hsa-mir-122	Varicella	24759212	disease by infectious agent	DOID:8659	B01	D002644			Dysregulated microRNA expression in serum of non-vaccinated children with varicella.
tissue_expression_ns	hsa-mir-132	Varicella	24759212	disease by infectious agent	DOID:8659	B01	D002644			Dysregulated microRNA expression in serum of non-vaccinated children with varicella.
tissue_expression_ns	hsa-mir-197	Varicella	24759212	disease by infectious agent	DOID:8659	B01	D002644			Dysregulated microRNA expression in serum of non-vaccinated children with varicella.
tissue_expression_ns	hsa-mir-363	Varicella	24759212	disease by infectious agent	DOID:8659	B01	D002644			Dysregulated microRNA expression in serum of non-vaccinated children with varicella.
tissue_expression_ns	hsa-mir-629	Varicella	24759212	disease by infectious agent	DOID:8659	B01	D002644			Dysregulated microRNA expression in serum of non-vaccinated children with varicella.
tissue_expression_ns	hsa-mir-126	Vascular Disease [unspecific]	28082910	cardiovascular system disease	DOID:178	I72.9	D000783			Acute Effects of Different Exercise Protocols on the Circulating Vascular microRNAs -16, -21, and -126 in Trained Subjects.
tissue_expression_ns	hsa-mir-143	Vascular Disease [unspecific]	24166492	cardiovascular system disease	DOID:178	I72.9	D000783			The flank sequences of miR-145 and miR-143 play a critical role in their aberrant expression in VSMCs and vascular walls. The genetically engineered smart miRNAs based on their flank sequences may have broadly therapeutic applications for many vascular diseases.
tissue_expression_ns	hsa-mir-145	Vascular Disease [unspecific]	24166492	cardiovascular system disease	DOID:178	I72.9	D000783			The flank sequences of miR-145 and miR-143 play a critical role in their aberrant expression in VSMCs and vascular walls. The genetically engineered smart miRNAs based on their flank sequences may have broadly therapeutic applications for many vascular diseases.
tissue_expression_ns	hsa-mir-16	Vascular Disease [unspecific]	28082910	cardiovascular system disease	DOID:178	I72.9	D000783			Acute Effects of Different Exercise Protocols on the Circulating Vascular microRNAs -16, -21, and -126 in Trained Subjects.
tissue_expression_ns	hsa-mir-21	Vascular Disease [unspecific]	28082910	cardiovascular system disease	DOID:178	I72.9	D000783			Acute Effects of Different Exercise Protocols on the Circulating Vascular microRNAs -16, -21, and -126 in Trained Subjects.
tissue_expression_ns	hsa-mir-1	Vascular Hypertrophy	27831640							Influence and significance of intervening diabetes microRNA expression profile of NOD mice with exendin-4.
tissue_expression_ns	hsa-mir-133	Vascular Hypertrophy	20015039							Lately, some highlight articles revealed that the altered expression of miRNAs such as miR-1, miR-133, miR-21, miR-208 etc in hearts also contributed to cardiovascular diseases, such as heart ischemia, cardiac hypertrophy, and arrhythmias.
tissue_expression_ns	hsa-mir-206	Vascular Hypertrophy	23842077							 miR-206 was depressed in the hypertrophied RV of Hx rats but was increased in growth-retarded SM.
tissue_expression_ns	hsa-mir-208	Vascular Hypertrophy	20015039							Lately, some highlight articles revealed that the altered expression of miRNAs such as miR-1, miR-133, miR-21, miR-208 etc in hearts also contributed to cardiovascular diseases, such as heart ischemia, cardiac hypertrophy, and arrhythmias.
tissue_expression_ns	hsa-mir-21	Viral Myocarditis	23544605			B33.2	D009205			Myocardial miR-21 expression was negatively related to viral myocarditis severity.
tissue_expression_ns	hsa-mir-146a	Vogt-Koyanagi-Harada Disease	26818976	immune system disease	DOID:12297	H20.82	D014607			CNVs of miR-146a, miR-23a and miR-301a confer susceptibility to VKH syndrome, but not to BD.
tissue_expression_ns	hsa-mir-103a	Vulvar Squamous Tumor	29299981	disease of cellular proliferation	DOID:2072					Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples
tissue_expression_ns	hsa-mir-16	Vulvar Squamous Tumor	29299981	disease of cellular proliferation	DOID:2072					Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples
tissue_expression_ns	hsa-mir-191	Vulvar Squamous Tumor	29299981	disease of cellular proliferation	DOID:2072					Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples
tissue_expression_ns	hsa-mir-423	Vulvar Squamous Tumor	29299981	disease of cellular proliferation	DOID:2072					Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples
tissue_expression_ns	hsa-mir-425	Vulvar Squamous Tumor	29299981	disease of cellular proliferation	DOID:2072					Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples
tissue_expression_ns	hsa-mir-93	Vulvar Squamous Tumor	29299981	disease of cellular proliferation	DOID:2072					Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples
tissue_expression_ns	hsa-mir-205	Wounds and Injuries [unspecific]	23861701				D014947			we predicted that topical treatment of shikonin in vivo affects epithelial-mesenchymal transition (EMT) and the expression of related microRNAs, including 200a, 200b, 200c, 141, 205, and 429 microRNAs, in mouse skin tissues.
tissue_expression_up	hsa-mir-1224	Acute Kidney Failure	24695114	urinary system disease	DOID:3021	N17.9	D058186		HP:0001919	Ischemia-reperfusion caused highly reproducible, progressive, concordant elevation of miR-714, miR-1188, miR-1897-3p, miR-877*, and miR-1224 in plasma and kidneys at 3, 6 and 24 hours after acute kidney injury compared to the sham-operated mice (n鈥?鈥?).
tissue_expression_up	hsa-mir-21	Acute Kidney Failure	26577279	urinary system disease	DOID:3021	N17.9	D058186		HP:0001919	A set of microRNAs was differentially expressed after renal damage, among them miR-21, which was up-regulated.
tissue_expression_up	hsa-mir-16-1	Acute Lung Injury	22940131			S27	D055371			miR-16 upregulates ENaC, a major sodium channel involved in resolution of pulmonary edema in acute lung injury.
tissue_expression_up	hsa-mir-16-2	Acute Lung Injury	22940131			S27	D055371			miR-16 upregulates ENaC, a major sodium channel involved in resolution of pulmonary edema in acute lung injury.
tissue_expression_up	hsa-mir-21	Acute Lung Injury	24736893			S27	D055371			miR-21 was upregulated in the OA group throughout the 24 h following OA challenge.
tissue_expression_up	hsa-mir-1	Acute Myocardial Infarction	26046358	cardiovascular system disease	DOID:9408	I21	D056989	608446	HP:0001658	This study highlights the stability of miRNAs after death and long-term fixation, validating their use as reliable biomarkers for AMI during postmortem examination.
tissue_expression_up	hsa-mir-208b	Acute Myocardial Infarction	26046358	cardiovascular system disease	DOID:9408	I21	D056989	608446	HP:0001658	This study highlights the stability of miRNAs after death and long-term fixation, validating their use as reliable biomarkers for AMI during postmortem examination.
tissue_expression_up	hsa-mir-29a	Acute Pancreatitis	27239114	endocrine system disease	DOID:2913	K85	D019283	167800	HP:0001735	The expression of miR-29a was much higher in the AEP group compared with the control group
tissue_expression_up	hsa-mir-125b	Acute Peritonitis	28074870	gastrointestinal system disease	DOID:8283	K65.0	D010538		HP:0002586	MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis.
tissue_expression_up	hsa-mir-107	Adenocarcinoma, Colon	27658891	disease of cellular proliferation	DOID:234	C18			HP:0040276	the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -322b (downregulated)
tissue_expression_up	hsa-mir-143	Adenocarcinoma, Colon	27658891	disease of cellular proliferation	DOID:234	C18			HP:0040276	the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -321b (downregulated)
tissue_expression_up	hsa-mir-145	Adenocarcinoma, Colon	27658891	disease of cellular proliferation	DOID:234	C18			HP:0040276	the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -320b (downregulated)
tissue_expression_up	hsa-mir-16	Adenocarcinoma, Colon	27930363	disease of cellular proliferation	DOID:234	C18			HP:0040276	Upregulated miR-16 expression is an independent indicator of relapse and poor overall survival of colorectal adenocarcinoma patients.
tissue_expression_up	hsa-mir-194	Adenocarcinoma, Colon	27658891	disease of cellular proliferation	DOID:234	C18			HP:0040276	the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -323b (downregulated)
tissue_expression_up	hsa-mir-21	Adenocarcinoma, Colon	19672269	disease of cellular proliferation	DOID:234	C18			HP:0040276	expression Increased
tissue_expression_up	hsa-mir-24	Adenocarcinoma, Colon	27939727	disease of cellular proliferation	DOID:234	C18			HP:0040276	Elevated expression of miR-24-3p is a potentially adverse prognostic factor in colorectal adenocarcinoma.
tissue_expression_up	hsa-mir-26a	Adenocarcinoma, Colon	27658891	disease of cellular proliferation	DOID:234	C18			HP:0040276	the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -324b (downregulated)
tissue_expression_up	hsa-mir-103a-1	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-103: upregulated
tissue_expression_up	hsa-mir-103a-2	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-103: upregulated
tissue_expression_up	hsa-mir-106a	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-106a: upregulated
tissue_expression_up	hsa-mir-151a	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-151: upregulated
tissue_expression_up	hsa-mir-155	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-155: upregulated
tissue_expression_up	hsa-mir-182	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-182: upregulated
tissue_expression_up	hsa-mir-183	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-183: upregulated
tissue_expression_up	hsa-mir-194-1	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-194: upregulated
tissue_expression_up	hsa-mir-194-2	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-194: upregulated
tissue_expression_up	hsa-mir-200a	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-200a: upregulated
tissue_expression_up	hsa-mir-200a	Adenocarcinoma, Endometrial	19891660	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	up-regulated
tissue_expression_up	hsa-mir-200b	Adenocarcinoma, Endometrial	19891660	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	up-regulated
tissue_expression_up	hsa-mir-200c	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-200c: upregulated
tissue_expression_up	hsa-mir-203	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-203: upregulated
tissue_expression_up	hsa-mir-205	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-205: upregulated
tissue_expression_up	hsa-mir-205	Adenocarcinoma, Endometrial	19077565	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-205: upregulated
tissue_expression_up	hsa-mir-205	Adenocarcinoma, Endometrial	19891660	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	up-regulated
tissue_expression_up	hsa-mir-210	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-210: upregulated
tissue_expression_up	hsa-mir-223	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-223: upregulated
tissue_expression_up	hsa-mir-429	Adenocarcinoma, Endometrial	19077565	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-429: upregulated
tissue_expression_up	hsa-mir-449a	Adenocarcinoma, Endometrial	19077565	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-449: upregulated
tissue_expression_up	hsa-mir-449b	Adenocarcinoma, Endometrial	19077565	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-449: upregulated
tissue_expression_up	hsa-mir-95	Adenocarcinoma, Endometrial	19065659	reproductive system disease	DOID:2870	C54.1	D018269	608089	HP:0012114	miR-95: upregulated
tissue_expression_up	hsa-mir-143	Adenocarcinoma, Esophageal	20301167	disease of cellular proliferation	DOID:4914		C562730	133239		upregulated
tissue_expression_up	hsa-mir-145	Adenocarcinoma, Esophageal	20301167	disease of cellular proliferation	DOID:4914		C562730	133239		upregulated
tissue_expression_up	hsa-mir-192	Adenocarcinoma, Esophageal	23724052	disease of cellular proliferation	DOID:4914		C562730	133239		6 miRNAs (up-regulated: miR-194, miR-31, miR-192, and miR-200a; down-regulated: miR-203 and miR-205) in EAC
tissue_expression_up	hsa-mir-194	Adenocarcinoma, Esophageal	23724052	disease of cellular proliferation	DOID:4914		C562730	133239		6 miRNAs (up-regulated: miR-194, miR-31, miR-192, and miR-200a; down-regulated: miR-203 and miR-205) in EAC
tissue_expression_up	hsa-mir-200a	Adenocarcinoma, Esophageal	23724052	disease of cellular proliferation	DOID:4914		C562730	133239		6 miRNAs (up-regulated: miR-194, miR-31, miR-192, and miR-200a; down-regulated: miR-203 and miR-205) in EAC
tissue_expression_up	hsa-mir-203	Adenocarcinoma, Esophageal	20301167	disease of cellular proliferation	DOID:4914		C562730	133239		miR-203:Levels of miR-203 and miR-205 were high in normal squamous epithelium and low in columnar epithelia
tissue_expression_up	hsa-mir-203	Adenocarcinoma, Esophageal	23724052	disease of cellular proliferation	DOID:4914		C562730	133239		6 miRNAs (up-regulated: miR-194, miR-31, miR-192, and miR-200a; down-regulated: miR-203 and miR-205) in EAC
tissue_expression_up	hsa-mir-205	Adenocarcinoma, Esophageal	20301167	disease of cellular proliferation	DOID:4914		C562730	133239		miR-205:Levels of miR-203 and miR-205 were high in normal squamous epithelium and low in columnar epithelia
tissue_expression_up	hsa-mir-205	Adenocarcinoma, Esophageal	23724052	disease of cellular proliferation	DOID:4914		C562730	133239		6 miRNAs (up-regulated: miR-194, miR-31, miR-192, and miR-200a; down-regulated: miR-203 and miR-205) in EAC
tissue_expression_up	hsa-mir-21	Adenocarcinoma, Esophageal	20301167	disease of cellular proliferation	DOID:4914		C562730	133239		upregulated
tissue_expression_up	hsa-mir-21	Adenocarcinoma, Esophageal	25950983	disease of cellular proliferation	DOID:4914		C562730	133239		microRNA-21 expression is elevated in esophageal adenocarcinoma after neoadjuvant chemotherapy.
tissue_expression_up	hsa-mir-21	Adenocarcinoma, Esophageal	25746664	disease of cellular proliferation	DOID:4914		C562730	133239		miRs such as miR-192, miR-196 and miR-21 were frequently noted to up-regulated whereas miR-203, miR-205 and miR-let-7 were commonly down-regulated during the development of Barrett's oesophagus to oesophageal adenocarcinoma.
tissue_expression_up	hsa-mir-210	Adenocarcinoma, Esophageal	28968550	disease of cellular proliferation	DOID:4914		C562730	133239		Expression levels of miR-25 and miR-210 were significantly higher, and  those of PTEN and AIFM3 significantly lower
tissue_expression_up	hsa-mir-215	Adenocarcinoma, Esophageal	20301167	disease of cellular proliferation	DOID:4914		C562730	133239		upregulated
tissue_expression_up	hsa-mir-221	Adenocarcinoma, Esophageal	27501171	disease of cellular proliferation	DOID:4914		C562730	133239		MiR-221 was overexpressed in 5-FU resistant EC cell lines as well as in  human EAC tissue.
tissue_expression_up	hsa-mir-25	Adenocarcinoma, Esophageal	28968550	disease of cellular proliferation	DOID:4914		C562730	133239		Expression levels of miR-25 and miR-210 were significantly higher, and  those of PTEN and AIFM3 significantly lower
tissue_expression_up	hsa-mir-31	Adenocarcinoma, Esophageal	23724052	disease of cellular proliferation	DOID:4914		C562730	133239		6 miRNAs (up-regulated: miR-194, miR-31, miR-192, and miR-200a; down-regulated: miR-203 and miR-205) in EAC
tissue_expression_up	hsa-mir-183	Adenocarcinoma, Lung	24805982	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	Up-regulation of microRNA-183-3p is a potent prognostic marker for lung adenocarcinoma of female non-smokers.
tissue_expression_up	hsa-mir-183	Adenocarcinoma, Lung	26170125	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	down-regulation of miR-34c and up-regulation of miR-183 and miR-210 were identified in caner groups
tissue_expression_up	hsa-mir-200c	Adenocarcinoma, Lung	20864637	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	miR-200c:Hsa-miR-193-3p was overexpressed in MPM, while hsa-miR-200c and hsa-miR-192 were overexpressed in peripheral lung adenocarcinoma and carcinomas
tissue_expression_up	hsa-mir-210	Adenocarcinoma, Lung	26170125	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	down-regulation of miR-34c and up-regulation of miR-183 and miR-210 were identified in caner groups
tissue_expression_up	hsa-mir-218	Adenocarcinoma, Lung	24705471	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	ADAM9 up-regulates N-cadherin via miR-218 suppression in lung adenocarcinoma cells.
tissue_expression_up	hsa-mir-26b	Adenocarcinoma, Lung	24815696	disease of cellular proliferation	DOID:3910	C78.00	C538231	211980	HP:0030078	Huaier suppresses proliferation and induces apoptosis in human pulmonary cancer cells via upregulation of miR-26b-5p.
tissue_expression_up	hsa-mir-196	Adenocarcinoma, Pancreatic Ductal	27267055	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		The expressions of all microRNAs were 1.4-3.7 times higher (significantly) in the PAC group compared to non-cancer patients.
tissue_expression_up	hsa-mir-200	Adenocarcinoma, Pancreatic Ductal	27267055	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		The expressions of all microRNAs were 1.4-3.7 times higher (significantly) in the PAC group compared to non-cancer patients.
tissue_expression_up	hsa-mir-21	Adenocarcinoma, Pancreatic Ductal	21757972	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		Elevated microRNA miR-21 Levels in Pancreatic Cyst Fluid Are Predictive of Mucinous Precursor Lesions of Ductal Adenocarcinoma.
tissue_expression_up	hsa-mir-506	Adenocarcinoma, Pancreatic Ductal	27371108	disease of cellular proliferation	DOID:3498	C25.3	D021441	260350		miR-506 expression was higher in PDAC
tissue_expression_up	hsa-mir-181a	Adenosquamous Pancreas Carcinoma	29221165	disease of cellular proliferation	DOID:5637					Furthermore, lower Ang-1 and Tie-2 transcript levels and higher increases of miR-21-5p, miR27a-3p and miR-181a-5p levels were found in the rarest form of pancreatic carcinoma.
tissue_expression_up	hsa-mir-21	Adenosquamous Pancreas Carcinoma	29221165	disease of cellular proliferation	DOID:5637					Furthermore, lower Ang-1 and Tie-2 transcript levels and higher increases of miR-21-5p, miR27a-3p and miR-181a-5p levels were found in the rarest form of pancreatic carcinoma.
tissue_expression_up	hsa-mir-27a	Adenosquamous Pancreas Carcinoma	29221165	disease of cellular proliferation	DOID:5637					Furthermore, lower Ang-1 and Tie-2 transcript levels and higher increases of miR-21-5p, miR27a-3p and miR-181a-5p levels were found in the rarest form of pancreatic carcinoma.
tissue_expression_up	hsa-mir-1246	Adenovirus Infection	20634878			B34.0	D000257			miR-1246:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-1247	Adenovirus Infection	20634878			B34.0	D000257			miR-1247:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-1273a	Adenovirus Infection	20634878			B34.0	D000257			miR-1273:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-1302-1	Adenovirus Infection	20634878			B34.0	D000257			miR-1302-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-1302-2	Adenovirus Infection	20634878			B34.0	D000257			miR-1302-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-1302-3	Adenovirus Infection	20634878			B34.0	D000257			miR-1302-3:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-1302-4	Adenovirus Infection	20634878			B34.0	D000257			miR-1302-4:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-1302-5	Adenovirus Infection	20634878			B34.0	D000257			miR-1302-5:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-1302-6	Adenovirus Infection	20634878			B34.0	D000257			miR-1302-6:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-1302-7	Adenovirus Infection	20634878			B34.0	D000257			miR-1302-7:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-1302-8	Adenovirus Infection	20634878			B34.0	D000257			miR-1302-8:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-146b	Adenovirus Infection	20634878			B34.0	D000257			miR-146b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-150	Adenovirus Infection	20634878			B34.0	D000257			miR-150:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-17	Adenovirus Infection	20634878			B34.0	D000257			miR-17:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-181b	Adenovirus Infection	25744056			B34.0	D000257			The expression patterns of these miRNAs changed dramatically during the course of the infection
tissue_expression_up	hsa-mir-18a	Adenovirus Infection	20634878			B34.0	D000257			miR-18a:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-191	Adenovirus Infection	20634878			B34.0	D000257			miR-191:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-191	Adenovirus Infection	25744056			B34.0	D000257			The expression patterns of these miRNAs changed dramatically during the course of the infection
tissue_expression_up	hsa-mir-1972-1	Adenovirus Infection	20634878			B34.0	D000257			miR-1972:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-320c-2	Adenovirus Infection	20634878			B34.0	D000257			miR-320c-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-324	Adenovirus Infection	20634878			B34.0	D000257			miR-324:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-342	Adenovirus Infection	20634878			B34.0	D000257			miR-342:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-345	Adenovirus Infection	20634878			B34.0	D000257			miR-345:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-378a	Adenovirus Infection	20634878			B34.0	D000257			miR-378:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-454	Adenovirus Infection	20634878			B34.0	D000257			miR-454:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-505	Adenovirus Infection	20634878			B34.0	D000257			miR-505:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-566	Adenovirus Infection	20634878			B34.0	D000257			miR-566:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-589	Adenovirus Infection	20634878			B34.0	D000257			miR-589:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-627	Adenovirus Infection	20634878			B34.0	D000257			miR-627:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-635	Adenovirus Infection	20634878			B34.0	D000257			miR-635:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-7-1	Adenovirus Infection	20634878			B34.0	D000257			miR-7-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-7-2	Adenovirus Infection	20634878			B34.0	D000257			miR-7-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-7-3	Adenovirus Infection	20634878			B34.0	D000257			miR-7-3:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-744	Adenovirus Infection	20634878			B34.0	D000257			miR-744:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-92a-1	Adenovirus Infection	20634878			B34.0	D000257			miR-92a-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-942	Adenovirus Infection	20634878			B34.0	D000257			miR-942:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control
tissue_expression_up	hsa-mir-210	Adrenal Cortex Neoplasms	19546168	disease of cellular proliferation	DOID:0050891	C74.0	D000306		HP:0100641	significantly higher expressed
tissue_expression_up	hsa-mir-210	Adrenal Cortex Neoplasms	19849700	disease of cellular proliferation	DOID:0050891	C74.0	D000306		HP:0100641	up-regulated
tissue_expression_up	hsa-mir-484	Adrenal Cortex Neoplasms	19849700	disease of cellular proliferation	DOID:0050891	C74.0	D000306		HP:0100641	up-regulated
tissue_expression_up	hsa-mir-503	Adrenal Cortex Neoplasms	19546168	disease of cellular proliferation	DOID:0050891	C74.0	D000306		HP:0100641	significantly higher expressed
tissue_expression_up	hsa-mir-467d	Alcoholic Cardiomyopathy	29734191			I42.6	D002310			The results demonstrated that miR-467d-3p and miR-491-5p were up-regulated and miR-3098-3p was down-regulated in the alcohol-exposed myocardial samples compared with the control samples (P < 0.05).
tissue_expression_up	hsa-mir-491	Alcoholic Cardiomyopathy	29734191			I42.6	D002310			The results demonstrated that miR-467d-3p and miR-491-5p were up-regulated and miR-3098-3p was down-regulated in the alcohol-exposed myocardial samples compared with the control samples (P < 0.05).
tissue_expression_up	hsa-mir-182	Alcoholic Hepatitis	27196584	endocrine system disease	DOID:12351	K70.1	D006519			miR-182 was the most highly expressed miRNA in AH
tissue_expression_up	hsa-mir-143	Allergic Rhinitis	24513959	respiratory system disease	DOID:4481	J30.9	D065631	607154	HP:0003193	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_up	hsa-mir-155	Allergic Rhinitis	23704072	respiratory system disease	DOID:4481	J30.9	D065631	607154	HP:0003193	Subjects with current allergic rhinitis symptoms had increased levels of miR-155, miR-205, and miR-498, but reduced levels of let-7e.
tissue_expression_up	hsa-mir-187	Allergic Rhinitis	24513959	respiratory system disease	DOID:4481	J30.9	D065631	607154	HP:0003193	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_up	hsa-mir-205	Allergic Rhinitis	23704072	respiratory system disease	DOID:4481	J30.9	D065631	607154	HP:0003193	Subjects with current allergic rhinitis symptoms had increased levels of miR-155, miR-205, and miR-498, but reduced levels of let-7e.
tissue_expression_up	hsa-mir-498	Allergic Rhinitis	23704072	respiratory system disease	DOID:4481	J30.9	D065631	607154	HP:0003193	Subjects with current allergic rhinitis symptoms had increased levels of miR-155, miR-205, and miR-498, but reduced levels of let-7e.
tissue_expression_up	hsa-mir-498	Allergic Rhinitis	24513959	respiratory system disease	DOID:4481	J30.9	D065631	607154	HP:0003193	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_up	hsa-mir-874	Allergic Rhinitis	24513959	respiratory system disease	DOID:4481	J30.9	D065631	607154	HP:0003193	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_up	hsa-mir-886	Allergic Rhinitis	24513959	respiratory system disease	DOID:4481	J30.9	D065631	607154	HP:0003193	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_up	hsa-mir-7-1	Allergic Rhinitis,Perennial	22185732			J30.89	D012221	607154		up-regulated
tissue_expression_up	hsa-mir-7-2	Allergic Rhinitis,Perennial	22185732			J30.89	D012221	607154		up-regulated
tissue_expression_up	hsa-mir-7-3	Allergic Rhinitis,Perennial	22185732			J30.89	D012221	607154		up-regulated
tissue_expression_up	hsa-mir-106a	Alopecia	21967250	integumentary system disease	DOID:987	L65.9	D000505	300042	HP:0001596	We detected the significant upregulation of miR-221, miR-125b, miR-106a and miR-410 in balding papilla cells.
tissue_expression_up	hsa-mir-125b	Alopecia	21967250	integumentary system disease	DOID:987	L65.9	D000505	300042	HP:0001596	We detected the significant upregulation of miR-221, miR-125b, miR-106a and miR-410 in balding papilla cells.
tissue_expression_up	hsa-mir-221	Alopecia	21967250	integumentary system disease	DOID:987	L65.9	D000505	300042	HP:0001596	We detected the significant upregulation of miR-221, miR-125b, miR-106a and miR-410 in balding papilla cells.
tissue_expression_up	hsa-mir-410	Alopecia	21967250	integumentary system disease	DOID:987	L65.9	D000505	300042	HP:0001596	We detected the significant upregulation of miR-221, miR-125b, miR-106a and miR-410 in balding papilla cells.
tissue_expression_up	hsa-mir-148a	Alzheimer Disease	21834602	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	upregulated in bone marrow plasma cells from patients with immunoglobulin light chain (AL) amyloidosis compared with controls.
tissue_expression_up	hsa-mir-16-2	Alzheimer Disease	21834602	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	upregulated in bone marrow plasma cells from patients with immunoglobulin light chain (AL) amyloidosis compared with controls.
tissue_expression_up	hsa-mir-206	Alzheimer Disease	24604632	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	We now report that miR-206 is upregulated in the hippocampal tissue, cerebrospinal fluid, and plasma of embryonic APP/PS1 transgenic mice.
tissue_expression_up	hsa-mir-21	Alzheimer Disease	19683563	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	up-regulated,  inhibits bcl2 translation
tissue_expression_up	hsa-mir-26a-1	Alzheimer Disease	21834602	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	upregulated in bone marrow plasma cells from patients with immunoglobulin light chain (AL) amyloidosis compared with controls.
tissue_expression_up	hsa-mir-26a-2	Alzheimer Disease	21834602	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	upregulated in bone marrow plasma cells from patients with immunoglobulin light chain (AL) amyloidosis compared with controls.
tissue_expression_up	hsa-mir-26b	Alzheimer Disease	24027266	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry,tau-phosphorylation, and apoptosis in postmitotic neurons.
tissue_expression_up	hsa-mir-34a	Alzheimer Disease	27235866	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	miR-34a over expression in patient's tissue
tissue_expression_up	hsa-mir-34c	Alzheimer Disease	21946562	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	The authors identify miR-34c as a negative constraint of memory consolidation and show that miR-34c levels are elevated in the hippocampus of AD patients and corresponding mouse models.
tissue_expression_up	hsa-mir-34c	Alzheimer Disease	25052764	nervous system disease	DOID:10652	G30.9	D000544	104300	HP:0002511	We have used an  in vivo neonatal mouse model to induce ketamine-related neurotoxicity in the hippocampus, and found that miR-34c, a microRNA associated with pathogenesis of Alzheimer's disease, was significantly upregulated during ketamine-induced hippocampal neurodegeneration.
tissue_expression_up	hsa-mir-125b	Amyotrophic Lateral Sclerosis	24336079	nervous system disease	DOID:332	G12.21	D000690	PS105400	HP:0007354	We identified upregulation of selected immune-enriched miRNAs, recognizing miR-22, miR-155, miR-125b and miR-146b among the most highly modulated.
tissue_expression_up	hsa-mir-146b	Amyotrophic Lateral Sclerosis	24336079	nervous system disease	DOID:332	G12.21	D000690	PS105400	HP:0007354	We identified upregulation of selected immune-enriched miRNAs, recognizing miR-22, miR-155, miR-125b and miR-146b among the most highly modulated.
tissue_expression_up	hsa-mir-132	Aneurysmal Subarachnoid Hemorrhage	26675167			I60	D013345		HP:0002138	Our study demonstrated that as compared to healthy control, miR-132 and miR-324 showed a upregulation in both SAH DCI and Non-DCI groups. However,the differences between the SAH DCI and non-DCI groups were not statistically significant.
tissue_expression_up	hsa-mir-324	Aneurysmal Subarachnoid Hemorrhage	26675167			I60	D013345		HP:0002138	Our study demonstrated that as compared to healthy control, miR-132 and miR-324 showed a upregulation in both SAH DCI and Non-DCI groups. However,the differences between the SAH DCI and non-DCI groups were not statistically significant.
tissue_expression_up	hsa-let-7i	Ankylosing Spondylitis	23607629	musculoskeletal system disease	DOID:7147	M45.9	D013167			In the functional studies, the increased let-7i expression facilitated the T helper type 1 (IFN-γ) immune response in T cells.
tissue_expression_up	hsa-mir-145	Aortic Aneurysm	25465469	cardiovascular system disease	DOID:3627	I71	D001014	100070	HP:0004942	The increased expression of microRNA-145 promotes media remodeling through TGF-b1 in the aortic aneurysm wall.
tissue_expression_up	hsa-mir-124a	Aortic Aneurysm, Abdominal	23316282	cardiovascular system disease	DOID:7693	I71.3-.4	D017544	PS100070		MicroRNAs related to fibrosis (miR-29b),inflammation (miR-124a, miR-146a, miR-155, and miR-223), and endothelium(miR-126, let-7 family members, and miR-21) were significantly upregulated in AAA tissue. 
tissue_expression_up	hsa-mir-126	Aortic Aneurysm, Abdominal	23316282	cardiovascular system disease	DOID:7693	I71.3-.4	D017544	PS100070		MicroRNAs related to fibrosis (miR-29b),inflammation (miR-124a, miR-146a, miR-155, and miR-223), and endothelium(miR-126, let-7 family members, and miR-21) were significantly upregulated in AAA tissue. 
tissue_expression_up	hsa-mir-146a	Aortic Aneurysm, Abdominal	23316282	cardiovascular system disease	DOID:7693	I71.3-.4	D017544	PS100070		MicroRNAs related to fibrosis (miR-29b),inflammation (miR-124a, miR-146a, miR-155, and miR-223), and endothelium(miR-126, let-7 family members, and miR-21) were significantly upregulated in AAA tissue. 
tissue_expression_up	hsa-mir-155	Aortic Aneurysm, Abdominal	23316282	cardiovascular system disease	DOID:7693	I71.3-.4	D017544	PS100070		MicroRNAs related to fibrosis (miR-29b),inflammation (miR-124a, miR-146a, miR-155, and miR-223), and endothelium(miR-126, let-7 family members, and miR-21) were significantly upregulated in AAA tissue. 
tissue_expression_up	hsa-mir-223	Aortic Aneurysm, Abdominal	23316282	cardiovascular system disease	DOID:7693	I71.3-.4	D017544	PS100070		MicroRNAs related to fibrosis (miR-29b),inflammation (miR-124a, miR-146a, miR-155, and miR-223), and endothelium(miR-126, let-7 family members, and miR-21) were significantly upregulated in AAA tissue. 
tissue_expression_up	hsa-mir-29b	Aortic Aneurysm, Abdominal	23316282	cardiovascular system disease	DOID:7693	I71.3-.4	D017544	PS100070		MicroRNAs related to fibrosis (miR-29b),inflammation (miR-124a, miR-146a, miR-155, and miR-223), and endothelium(miR-126, let-7 family members, and miR-21) were significantly upregulated in AAA tissue. 
tissue_expression_up	hsa-mir-126	Asthma	21605405	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	upregulated compared with normal control
tissue_expression_up	hsa-mir-126	Asthma	24615202	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	In mice models of asthma it has been found that increased levels of miR-21 and miR-126
tissue_expression_up	hsa-mir-126	Asthma	24995087	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Compared to the normal group, miR-21 and miR-126 expression was significantly upregulated in asthma patients regardless of treatment.
tissue_expression_up	hsa-mir-126	Asthma	27247924	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Elevated levels of miRNA-126, IL-13 mRNA and pathological changes were observed in the sensitized group compared to the control group
tissue_expression_up	hsa-mir-143	Asthma	24513959	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_up	hsa-mir-15a	Asthma	25979194	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	miRNA regulation network demonstrated that miR-16 and miR-15a had higher degree.
tissue_expression_up	hsa-mir-16	Asthma	25979194	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	miRNA regulation network demonstrated that miR-16 and miR-15a had higher degree.
tissue_expression_up	hsa-mir-187	Asthma	24513959	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_up	hsa-mir-221	Asthma	22895815	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Upregulation of miRNA-221 and miRNA-485-3p in pediatric asthma.
tissue_expression_up	hsa-mir-485	Asthma	22895815	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Upregulation of miRNA-221 and miRNA-485-3p in pediatric asthma.
tissue_expression_up	hsa-mir-498	Asthma	24513959	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_up	hsa-mir-874	Asthma	24513959	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_up	hsa-mir-886	Asthma	24513959	respiratory system disease	DOID:2841	J45	D001249	600807	HP:0002099	Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic  patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR.
tissue_expression_up	hsa-mir-15a	Astrocytoma	26813564	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-15a and miR-24-1 were found upregulated in EP relapsed and EP deceased cases
tissue_expression_up	hsa-mir-195	Astrocytoma	20976148	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	The observation that miR-34a and miR-195 levels were increased in the RISC of U-87 astrocytoma cells suggests an oncogenic role for these miRNAs.
tissue_expression_up	hsa-mir-21	Astrocytoma	19159078	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-21: upregulation
tissue_expression_up	hsa-mir-21	Astrocytoma	20219352	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-21:hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma
tissue_expression_up	hsa-mir-21	Astrocytoma	20711171	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	Inhibition of two glioblastoma-upregulated miRNAs (miR-21 and miR-23a) and exogenous overexpression of two glioblastoma-downregulated miRNAs (miR-218 and miR-219-5p) resulted in reduced soft agar colony formation but showed varying effects on cell proliferation and chemosensitivity.
tissue_expression_up	hsa-mir-221	Astrocytoma	19159078	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-221: upregulation
tissue_expression_up	hsa-mir-23a	Astrocytoma	20711171	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	Inhibition of two glioblastoma-upregulated miRNAs (miR-21 and miR-23a) and exogenous overexpression of two glioblastoma-downregulated miRNAs (miR-218 and miR-219-5p) resulted in reduced soft agar colony formation but showed varying effects on cell proliferation and chemosensitivity.
tissue_expression_up	hsa-mir-24	Astrocytoma	26813564	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	miR-15a and miR-24-1 were found upregulated in EP relapsed and EP deceased cases
tissue_expression_up	hsa-mir-34a	Astrocytoma	20976148	disease of cellular proliferation	DOID:3069	C72.9	D001254	155755	HP:0009592	The observation that miR-34a and miR-195 levels were increased in the RISC of U-87 astrocytoma cells suggests an oncogenic role for these miRNAs.
tissue_expression_up	hsa-mir-126	Atherosclerosis	27288564	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Aroclor 1260 increased miR-21, miR-31, miR-126, miR-221 and miR-222 expression levels.
tissue_expression_up	hsa-mir-142	Atherosclerosis	25586666	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	the upregulation of miR-142-5p expression may regulate apoptosis in human macrophages by targeting TGF-β2. This effect may have an important role in the progression of atherosclerosis.
tissue_expression_up	hsa-mir-146b	Atherosclerosis	25743474	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Aa challenge significantly increased the expression of miR-146b and miR-155 in the aorta.
tissue_expression_up	hsa-mir-155	Atherosclerosis	25872580	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	our data demonstrate that miR-155 is significantly upregulated in atherosclerotic plaque, functioning to accelerate the proliferation and migration of VSMCs by targeting eNOS.
tissue_expression_up	hsa-mir-155	Atherosclerosis	29642385	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Exposure to the high dose of CS also significantly upregulated the miRNA-155 level in the aortic tissues of ApoE KO mice
tissue_expression_up	hsa-mir-21	Atherosclerosis	27288564	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Aroclor 1260 increased miR-21, miR-31, miR-126, miR-221 and miR-222 expression levels.
tissue_expression_up	hsa-mir-21	Atherosclerosis	29642385	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Moreover, the expression level of miR-126 tended to be downregulated and that of miR-21 tended to be upregulated in ApoE KO mice exposed to the high dose of CS, albeit statistically insignificant
tissue_expression_up	hsa-mir-221	Atherosclerosis	27288564	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Aroclor 1260 increased miR-21, miR-31, miR-126, miR-221 and miR-222 expression levels.
tissue_expression_up	hsa-mir-222	Atherosclerosis	27288564	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Aroclor 1260 increased miR-21, miR-31, miR-126, miR-221 and miR-222 expression levels.
tissue_expression_up	hsa-mir-223	Atherosclerosis	26492242	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	an obvious increase  of miR-223 was observed in aortic atherosclerotic lesions.
tissue_expression_up	hsa-mir-31	Atherosclerosis	27288564	cardiovascular system disease	DOID:1936	I70	D050197	108725	HP:0002621	Aroclor 1260 increased miR-21, miR-31, miR-126, miR-221 and miR-222 expression levels.
tissue_expression_up	hsa-mir-142	Atopic Dermatitis	22594804	integumentary system disease	DOID:3310	L20	D003876	PS603165	HP:0001047	In humans sensitized with DPCP, we found significant upregulation of miR-21, miR-142-3p, miR-142-5p and miR-223 in challenged skin.
tissue_expression_up	hsa-mir-21	Atopic Dermatitis	17622355	integumentary system disease	DOID:3310	L20	D003876	PS603165	HP:0001047	miR-21 was significantly up-regulated both psoriasis (p<0.001) and atopic eczema (p<0.001) as compared with healthy skin.
tissue_expression_up	hsa-mir-21	Atopic Dermatitis	22594804	integumentary system disease	DOID:3310	L20	D003876	PS603165	HP:0001047	In humans sensitized with DPCP, we found significant upregulation of miR-21, miR-142-3p, miR-142-5p and miR-223 in challenged skin.
tissue_expression_up	hsa-mir-223	Atopic Dermatitis	22594804	integumentary system disease	DOID:3310	L20	D003876	PS603165	HP:0001047	In humans sensitized with DPCP, we found significant upregulation of miR-21, miR-142-3p, miR-142-5p and miR-223 in challenged skin.
tissue_expression_up	hsa-mir-142	Atrial Fibrillation	22944230	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated  in left atrial appendage (LAA) in patients with atrial fibrillation.
tissue_expression_up	hsa-mir-146b	Atrial Fibrillation	22944230	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated  in left atrial appendage (LAA) in patients with atrial fibrillation.
tissue_expression_up	hsa-mir-146b	Atrial Fibrillation	26319023	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Expression of inflammation-associated miRNAs is significantly up-regulated in the left atrial appendage of patients with non-valvular paroxysmal atrial fibrillation, which may play a significant role in electrical and structural remodeling.
tissue_expression_up	hsa-mir-155	Atrial Fibrillation	22944230	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated  in left atrial appendage (LAA) in patients with atrial fibrillation.
tissue_expression_up	hsa-mir-155	Atrial Fibrillation	26319023	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Expression of inflammation-associated miRNAs is significantly up-regulated in the left atrial appendage of patients with non-valvular paroxysmal atrial fibrillation, which may play a significant role in electrical and structural remodeling.
tissue_expression_up	hsa-mir-193b	Atrial Fibrillation	22944230	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated  in left atrial appendage (LAA) in patients with atrial fibrillation.
tissue_expression_up	hsa-mir-19a	Atrial Fibrillation	22944230	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated  in left atrial appendage (LAA) in patients with atrial fibrillation.
tissue_expression_up	hsa-mir-19b	Atrial Fibrillation	26319023	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Expression of inflammation-associated miRNAs is significantly up-regulated in the left atrial appendage of patients with non-valvular paroxysmal atrial fibrillation, which may play a significant role in electrical and structural remodeling.
tissue_expression_up	hsa-mir-19b-1	Atrial Fibrillation	22944230	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated  in left atrial appendage (LAA) in patients with atrial fibrillation.
tissue_expression_up	hsa-mir-19b-2	Atrial Fibrillation	22944230	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated  in left atrial appendage (LAA) in patients with atrial fibrillation.
tissue_expression_up	hsa-mir-223	Atrial Fibrillation	22944230	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated  in left atrial appendage (LAA) in patients with atrial fibrillation.
tissue_expression_up	hsa-mir-328	Atrial Fibrillation	23710743	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	miR-328 expression is significantly increased in patients with AF
tissue_expression_up	hsa-mir-483	Atrial Fibrillation	27422887	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	Sixteen microRNAs were differentially expressed in the atrial myocardium of POAF patients when compared with those maintaining sinus rhythm. miR-208a was  the most underexpressed [fold change (FC) = 2.458] and miR-483-5p the most overexpressed (FC = 1.804).
tissue_expression_up	hsa-mir-486	Atrial Fibrillation	22944230	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated  in left atrial appendage (LAA) in patients with atrial fibrillation.
tissue_expression_up	hsa-mir-519b	Atrial Fibrillation	22944230	cardiovascular system disease	DOID:0060224	I48.0	D001281	PS608583	HP:0005110	MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated  in left atrial appendage (LAA) in patients with atrial fibrillation.
tissue_expression_up	hsa-mir-125a	Autoimmune Thyroiditis	25863684	immune system disease	DOID:7188	E06.3	D013967	109100		Decreased expression of microRNA-125a-3p upregulates interleukin-23 receptor in patients with Hashimoto's thyroiditis.
tissue_expression_up	hsa-mir-141	Azoospermia	23559187	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p
tissue_expression_up	hsa-mir-429	Azoospermia	23559187	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p
tissue_expression_up	hsa-mir-7-1	Azoospermia	23559187	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p
tissue_expression_up	hsa-mir-7-2	Azoospermia	23559187	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p
tissue_expression_up	hsa-mir-7-3	Azoospermia	23559187	reproductive system disease	DOID:14227	N46.0	D053713		HP:0000027	Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p
tissue_expression_up	hsa-mir-143	Barrett Esophagus	27374102	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	miR-143, miR-145, miR-194 and miR-215 levels were significantly higher
tissue_expression_up	hsa-mir-192	Barrett Esophagus	22094011	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	We demonstrated unequivocal statistically significant upregulation of two microRNAs (miR-192, 196a) and downregulation of miR-203 and positive miR-196a correlation with progression from intestinal metaplasia to adenocarcinoma compared to normal individuals.
tissue_expression_up	hsa-mir-194	Barrett Esophagus	27374102	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	miR-143, miR-145, miR-194 and miR-215 levels were significantly higher
tissue_expression_up	hsa-mir-196a-1	Barrett Esophagus	22094011	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	We demonstrated unequivocal statistically significant upregulation of two microRNAs (miR-192, 196a) and downregulation of miR-203 and positive miR-196a correlation with progression from intestinal metaplasia to adenocarcinoma compared to normal individuals.
tissue_expression_up	hsa-mir-196a-2	Barrett Esophagus	22094011	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	We demonstrated unequivocal statistically significant upregulation of two microRNAs (miR-192, 196a) and downregulation of miR-203 and positive miR-196a correlation with progression from intestinal metaplasia to adenocarcinoma compared to normal individuals.
tissue_expression_up	hsa-mir-205	Barrett Esophagus	26711784	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	we observed significantly higher levels of miR-205 in tumor tissue of esophageal squamous cell carcinoma
tissue_expression_up	hsa-mir-215	Barrett Esophagus	27374102	gastrointestinal system disease	DOID:9206	K22.7	D001471	614266	HP:0100580	miR-143, miR-145, miR-194 and miR-215 levels were significantly higher
tissue_expression_up	hsa-mir-155	Behcet Disease	27156371	cardiovascular system disease	DOID:13241	M35.2	D001528	109650		The expression of miR-155 and IL-17 was significantly increased in CD4+  T cells of patients with active BD.
tissue_expression_up	hsa-mir-182	Behcet Disease	28482290	cardiovascular system disease	DOID:13241	M35.2	D001528	109650		up regulation of miR-182 and miR-3591-3p; down regulation of miR-155, miR-638 and miR-4488 in the pathogenesis of the disease
tissue_expression_up	hsa-mir-3591	Behcet Disease	28482290	cardiovascular system disease	DOID:13241	M35.2	D001528	109650		up regulation of miR-182 and miR-3591-3p; down regulation of miR-155, miR-638 and miR-4488 in the pathogenesis of the disease
tissue_expression_up	hsa-let-7f-2	Biliary Tract Neoplasms	21858175	disease of cellular proliferation	DOID:0050625	C24.9	D001661		HP:0100574	The miRNA let-7f-2* was significantly more highly expressed in the malignant group than in the benign group.
tissue_expression_up	hsa-let-7i	Biliary Tract Neoplasms	21858175	disease of cellular proliferation	DOID:0050625	C24.9	D001661		HP:0100574	The miRNA let-7i* was significantly more highly expressed in the malignant group than in the benign group.
tissue_expression_up	hsa-mir-105-1	Biliary Tract Neoplasms	21858175	disease of cellular proliferation	DOID:0050625	C24.9	D001661		HP:0100574	The miRNA was significantly more highly expressed in the malignant group than in the benign group.
tissue_expression_up	hsa-mir-105-2	Biliary Tract Neoplasms	21858175	disease of cellular proliferation	DOID:0050625	C24.9	D001661		HP:0100574	The miRNA was significantly more highly expressed in the malignant group than in the benign group.
tissue_expression_up	hsa-mir-141	Biliary Tract Neoplasms	27172928	disease of cellular proliferation	DOID:0050625	C24.9	D001661		HP:0100574	Overexpression of miRNA 141 is an indicator of a poor prognosis in patients with biliary tract cancer
tissue_expression_up	hsa-mir-145	Biliary Tract Neoplasms	21858175	disease of cellular proliferation	DOID:0050625	C24.9	D001661		HP:0100574	The miRNA miR-145* was significantly more highly expressed in the malignant group than in the benign group.
tissue_expression_up	hsa-mir-147b	Biliary Tract Neoplasms	21858175	disease of cellular proliferation	DOID:0050625	C24.9	D001661		HP:0100574	The miRNA was significantly more highly expressed in the malignant group than in the benign group.
tissue_expression_up	hsa-mir-199a-1	Biliary Tract Neoplasms	21858175	disease of cellular proliferation	DOID:0050625	C24.9	D001661		HP:0100574	The miRNA miR-199a-3p was significantly more highly expressed in the malignant group than in the benign group.
tissue_expression_up	hsa-mir-199a-2	Biliary Tract Neoplasms	21858175	disease of cellular proliferation	DOID:0050625	C24.9	D001661		HP:0100574	The miRNA miR-199a-3p was significantly more highly expressed in the malignant group than in the benign group.
tissue_expression_up	hsa-mir-222	Biliary Tract Neoplasms	21858175	disease of cellular proliferation	DOID:0050625	C24.9	D001661		HP:0100574	The miRNA miR-222* was significantly more highly expressed in the malignant group than in the benign group.
tissue_expression_up	hsa-mir-302c	Biliary Tract Neoplasms	21858175	disease of cellular proliferation	DOID:0050625	C24.9	D001661		HP:0100574	The miRNA miR-302c* was significantly more highly expressed in the malignant group than in the benign group.
tissue_expression_up	hsa-mir-9-1	Biliary Tract Neoplasms	21858175	disease of cellular proliferation	DOID:0050625	C24.9	D001661		HP:0100574	The miRNA was significantly more highly expressed in the malignant group than in the benign group.
tissue_expression_up	hsa-mir-9-2	Biliary Tract Neoplasms	21858175	disease of cellular proliferation	DOID:0050625	C24.9	D001661		HP:0100574	The miRNA was significantly more highly expressed in the malignant group than in the benign group.
tissue_expression_up	hsa-mir-9-3	Biliary Tract Neoplasms	21858175	disease of cellular proliferation	DOID:0050625	C24.9	D001661		HP:0100574	The miRNA was significantly more highly expressed in the malignant group than in the benign group.
tissue_expression_up	hsa-mir-942	Biliary Tract Neoplasms	21858175	disease of cellular proliferation	DOID:0050625	C24.9	D001661		HP:0100574	The miRNA was significantly more highly expressed in the malignant group than in the benign group.
tissue_expression_up	hsa-mir-100	Bladder Neoplasms	27350368			C67	D001749	109800	HP:0009725	six up-regulated candidate miRNAs (miR-182-5p, miR-935, miR-518e-3p, miR-573, miR-100-3p, and miR-3171)
tissue_expression_up	hsa-mir-103	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-103-1	Bladder Neoplasms	17826655			C67	D001749	109800	HP:0009725	Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa.
tissue_expression_up	hsa-mir-1233	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-130b	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-135b	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-137	Bladder Neoplasms	25330156			C67	D001749	109800	HP:0009725	MicroRNA-137 upregulation increases bladder cancer cell proliferation and invasion by targeting PAQR3.
tissue_expression_up	hsa-mir-138	Bladder Neoplasms	23169479			C67	D001749	109800	HP:0009725	three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)
tissue_expression_up	hsa-mir-141	Bladder Neoplasms	25304156			C67	D001749	109800	HP:0009725	Increased miR-141 expression is associated with diagnosis and favorable prognosis of patients with bladder cancer.
tissue_expression_up	hsa-mir-141	Bladder Neoplasms	25703910			C67	D001749	109800	HP:0009725	There was a more expression rate of miR-200c, miR-141 and miR-30b in bladder cancer tissues than healthy adjacent control tissues. Further studies are needed to draw final conclusion.
tissue_expression_up	hsa-mir-141	Bladder Neoplasms	25991007			C67	D001749	109800	HP:0009725	The present meta-analysis identified eight highly significant and consistently dysregulated miRNAs from 19 datasets. We also constructed an eight-miRNA signature which provided predictive and prognostic value that complements traditional clinicopathological risk factors.
tissue_expression_up	hsa-mir-141	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-145	Bladder Neoplasms	26196183			C67	D001749	109800	HP:0009725	The most hypoxia-upregulated miRNA was miR-145.
tissue_expression_up	hsa-mir-146b	Bladder Neoplasms	23169479			C67	D001749	109800	HP:0009725	Except for two miRNAs, miR-146b and miR-9, which were specifically upregulated in MIBC, the majority of miRNAs (n = 13) were deregulated in the same way in the two types of bladder tumors
tissue_expression_up	hsa-mir-15a	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-17	Bladder Neoplasms	17826655			C67	D001749	109800	HP:0009725	Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa.
tissue_expression_up	hsa-mir-182	Bladder Neoplasms	27350368			C67	D001749	109800	HP:0009725	six up-regulated candidate miRNAs (miR-182-5p, miR-935, miR-518e-3p, miR-573, miR-100-3p, and miR-3171)
tissue_expression_up	hsa-mir-182	Bladder Neoplasms	23169479			C67	D001749	109800	HP:0009725	three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)
tissue_expression_up	hsa-mir-182	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-183	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-185	Bladder Neoplasms	17826655			C67	D001749	109800	HP:0009725	Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa.
tissue_expression_up	hsa-mir-18a	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-190	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-191	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-19a	Bladder Neoplasms	25107371			C67	D001749	109800	HP:0009725	Our data indicated that miR-19a might act as an oncogenic microRNA in bladder cancer and was significantly up-regulated in bladder cancer carcinogenesis. The oncogenic role of miR19a in bladder cancer was dependent on targeting PTEN.
tissue_expression_up	hsa-mir-200b	Bladder Neoplasms	23169479			C67	D001749	109800	HP:0009725	three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)
tissue_expression_up	hsa-mir-200b	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-200c	Bladder Neoplasms	25703910			C67	D001749	109800	HP:0009725	There was a more expression rate of miR-200c, miR-141 and miR-30b in bladder cancer tissues than healthy adjacent control tissues. Further studies are needed to draw final conclusion.
tissue_expression_up	hsa-mir-200c	Bladder Neoplasms	25991007			C67	D001749	109800	HP:0009725	The present meta-analysis identified eight highly significant and consistently dysregulated miRNAs from 19 datasets. We also constructed an eight-miRNA signature which provided predictive and prognostic value that complements traditional clinicopathological risk factors.
tissue_expression_up	hsa-mir-203	Bladder Neoplasms	17826655			C67	D001749	109800	HP:0009725	Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa.
tissue_expression_up	hsa-mir-205	Bladder Neoplasms	17826655			C67	D001749	109800	HP:0009725	Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa.
tissue_expression_up	hsa-mir-21	Bladder Neoplasms	25991007			C67	D001749	109800	HP:0009725	The present meta-analysis identified eight highly significant and consistently dysregulated miRNAs from 19 datasets. We also constructed an eight-miRNA signature which provided predictive and prognostic value that complements traditional clinicopathological risk factors.
tissue_expression_up	hsa-mir-21	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-221	Bladder Neoplasms	17826655			C67	D001749	109800	HP:0009725	Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa.
tissue_expression_up	hsa-mir-222	Bladder Neoplasms	25078265			C67	D001749	109800	HP:0009725	Increased expression of miR-222 is associated with poor prognosis in bladder cancer.
tissue_expression_up	hsa-mir-223	Bladder Neoplasms	17826655			C67	D001749	109800	HP:0009725	Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa.
tissue_expression_up	hsa-mir-23a	Bladder Neoplasms	17826655			C67	D001749	109800	HP:0009725	Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa.
tissue_expression_up	hsa-mir-23b	Bladder Neoplasms	17826655			C67	D001749	109800	HP:0009725	Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa.
tissue_expression_up	hsa-mir-26b	Bladder Neoplasms	17826655			C67	D001749	109800	HP:0009725	Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa.
tissue_expression_up	hsa-mir-30b	Bladder Neoplasms	25703910			C67	D001749	109800	HP:0009725	There was a more expression rate of miR-200c, miR-141 and miR-30b in bladder cancer tissues than healthy adjacent control tissues. Further studies are needed to draw final conclusion.
tissue_expression_up	hsa-mir-3171	Bladder Neoplasms	27350368			C67	D001749	109800	HP:0009725	six up-regulated candidate miRNAs (miR-182-5p, miR-935, miR-518e-3p, miR-573, miR-100-3p, and miR-3171)
tissue_expression_up	hsa-mir-422b	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-425	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-449b	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-518e	Bladder Neoplasms	27350368			C67	D001749	109800	HP:0009725	six up-regulated candidate miRNAs (miR-182-5p, miR-935, miR-518e-3p, miR-573, miR-100-3p, and miR-3171)
tissue_expression_up	hsa-mir-573	Bladder Neoplasms	27350368			C67	D001749	109800	HP:0009725	six up-regulated candidate miRNAs (miR-182-5p, miR-935, miR-518e-3p, miR-573, miR-100-3p, and miR-3171)
tissue_expression_up	hsa-mir-601	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-639	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-644	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-649	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-708	Bladder Neoplasms	22393979			C67	D001749	109800	HP:0009725	Differential miRNA expression profiles in bladder urothelial carcinomas identified miR-100 down-regulation and miR-708 up-regulation among the most common alterations
tissue_expression_up	hsa-mir-9	Bladder Neoplasms	23169479			C67	D001749	109800	HP:0009725	Except for two miRNAs, miR-146b and miR-9, which were specifically upregulated in MIBC, the majority of miRNAs (n = 13) were deregulated in the same way in the two types of bladder tumors
tissue_expression_up	hsa-mir-93	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-935	Bladder Neoplasms	27350368			C67	D001749	109800	HP:0009725	six up-regulated candidate miRNAs (miR-182-5p, miR-935, miR-518e-3p, miR-573, miR-100-3p, and miR-3171)
tissue_expression_up	hsa-mir-96	Bladder Neoplasms	23266581			C67	D001749	109800	HP:0009725	Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort
tissue_expression_up	hsa-mir-21	Breast Ductal Carcinoma	19080492	thoracic disease	DOID:3007	D05.10	D044584			miR-21: expression is significantly higher than the normal controls
tissue_expression_up	hsa-mir-103a-1	Breast Neoplasms	20603000	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-103:In human breast cancer, high levels of miR-103/107 are associated with metastasis and poor outcome
tissue_expression_up	hsa-mir-103a-2	Breast Neoplasms	20603000	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-103:In human breast cancer, high levels of miR-103/107 are associated with metastasis and poor outcome
tissue_expression_up	hsa-mir-106a	Breast Neoplasms	20801493	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	A high correlation of miRNA expression level was found between breast tumor tissues and sera. MiR-21, miR-106a and miR-155 were significantly over-expressed in the tumor specimens compared with those in normal controls (P < 0.05), whereas miR-126, miR-199a and miR-335 were significantly under-expressed (P < 0.05).
tissue_expression_up	hsa-mir-107	Breast Neoplasms	20603000	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-107:In human breast cancer, high levels of miR-103/107 are associated with metastasis and poor outcome
tissue_expression_up	hsa-mir-10a	Breast Neoplasms	23968733	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Increased expression of miR-126 and miR-10a predict prolonged relapse-free time of primary oestrogen receptor-positive breast cancer following tamoxifen treatment.
tissue_expression_up	hsa-mir-10a	Breast Neoplasms	25266482	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	These findings indicate that higher expression of RUNX2 and miR-10a/b was associated with adverse outcome of breast cancer. Expression levels of RUNX2 and miR-10a/b individually or jointly are potential prognostic factors for predicting breast cancer recurrence. Data from in vitro studies support the notion that RUNX2 promoted cell motility by upregulating miR-10a/b.
tissue_expression_up	hsa-mir-10a	Breast Neoplasms	22524830	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The BC patients showed an up-regulation in miRNAs (mir-155, mir-10,mir-21 and mir-373)
tissue_expression_up	hsa-mir-10b	Breast Neoplasms	25266482	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	These findings indicate that higher expression of RUNX2 and miR-10a/b was associated with adverse outcome of breast cancer. Expression levels of RUNX2 and miR-10a/b individually or jointly are potential prognostic factors for predicting breast cancer recurrence. Data from in vitro studies support the notion that RUNX2 promoted cell motility by upregulating miR-10a/b.
tissue_expression_up	hsa-mir-10b	Breast Neoplasms	22057972	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas.
tissue_expression_up	hsa-mir-10b	Breast Neoplasms	22492962	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The levels of miR-10b and miR-21 are found significantly increased in the CSF (cerebrospinal fluid) of patients with glioblastoma and brain metastasis of breast and lung cancer, compared with tumors in remission and a variety of nonneoplastic conditions.
tissue_expression_up	hsa-mir-10b	Breast Neoplasms	22524830	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The BC patients showed an up-regulation in miRNAs (mir-155, mir-10,mir-21 and mir-373)
tissue_expression_up	hsa-mir-1-1	Breast Neoplasms	21931769	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	ATF-126 and Maspin cDNA induction led to the re-activation of tumor suppressive miRNAs also expressed in neural cells, such as miR-1 and miR-34, and to the down-regulation of potential oncogenic miRNAs, such as miR-10b, miR-124, and miR-363.
tissue_expression_up	hsa-mir-1-2	Breast Neoplasms	21931769	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	ATF-126 and Maspin cDNA induction led to the re-activation of tumor suppressive miRNAs also expressed in neural cells, such as miR-1 and miR-34, and to the down-regulation of potential oncogenic miRNAs, such as miR-10b, miR-124, and miR-363.
tissue_expression_up	hsa-mir-125b	Breast Neoplasms	25605244	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	up-regulation of miR-125b or targeting Sema4C could serve as novel approaches to reverse chemotherapy resistance in breast cancers.
tissue_expression_up	hsa-mir-125b-1	Breast Neoplasms	21409395	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells
tissue_expression_up	hsa-mir-125b-1	Breast Neoplasms	22523546	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-125b was significantly associated with therapeutic response, exhibiting higher expression level in non-responsive patients.
tissue_expression_up	hsa-mir-125b-2	Breast Neoplasms	21409395	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells
tissue_expression_up	hsa-mir-125b-2	Breast Neoplasms	22523546	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-125b was significantly associated with therapeutic response, exhibiting higher expression level in non-responsive patients.
tissue_expression_up	hsa-mir-126	Breast Neoplasms	23968733	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Increased expression of miR-126 and miR-10a predict prolonged relapse-free time of primary oestrogen receptor-positive breast cancer following tamoxifen treatment.
tissue_expression_up	hsa-mir-126	Breast Neoplasms	21409395	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells
tissue_expression_up	hsa-mir-127	Breast Neoplasms	21409395	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells
tissue_expression_up	hsa-mir-139	Breast Neoplasms	25027758	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Down-regulation of miR-486-5p and miR-139-5p, in conjunction with up-regulation of miR-21, may represent a useful signature for the identification of high-risk breast cancer patients.
tissue_expression_up	hsa-mir-143	Breast Neoplasms	21409395	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells
tissue_expression_up	hsa-mir-143	Breast Neoplasms	28588724	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Upregulation of microRNA-143 reverses drug resistance in human breast cancer cells via inhibition of cytokine-induced apoptosis inhibitor 1.
tissue_expression_up	hsa-mir-145	Breast Neoplasms	21409395	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells
tissue_expression_up	hsa-mir-146a	Breast Neoplasms	16461460	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	overexpressed
tissue_expression_up	hsa-mir-146b	Breast Neoplasms	16461460	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	overexpressed
tissue_expression_up	hsa-mir-146b	Breast Neoplasms	21409395	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells
tissue_expression_up	hsa-mir-151a	Breast Neoplasms	22489664	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-151-5p upregulation may suppress metastasis in primary breast tumors.
tissue_expression_up	hsa-mir-151b	Breast Neoplasms	22489664	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-151-5p upregulation may suppress metastasis in primary breast tumors.
tissue_expression_up	hsa-mir-155	Breast Neoplasms	16103053	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	upregulated
tissue_expression_up	hsa-mir-155	Breast Neoplasms	16461460	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	overexpressed
tissue_expression_up	hsa-mir-155	Breast Neoplasms	22105810	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The relative expression of miR-155 was significantly higher in breast cancer tissues than in corresponding nontumor tissues. High miR-155 expression was correlated with higher tumor grade, advanced tumor stage and lymph node metastasis (P=0.012, 0.001, and 0.003, respectively). Kaplan-Meier survival analysis indicated that the disease-free and overall survival rates of high miR-155 group were significantly lower than those of low miR-155 group (P=0.038 and 0.029, respectively). Multivariate analysis showed that high miR-155 expression was a poor prognostic factor (P=0.009). Furthermore, antisense targeting miR-155 could inhibit growth, induce cell arrest in G(0) /G(1) phase, enhance apoptosis, and increase radiosensitivity in breast cancer cells.
tissue_expression_up	hsa-mir-155	Breast Neoplasms	22524830	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The BC patients showed an up-regulation in miRNAs (mir-155, mir-10,mir-21 and mir-373)
tissue_expression_up	hsa-mir-155	Breast Neoplasms	23568502	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	17β-Estradiol up-regulates miR-155 expression and reduces TP53INP1 expression in MCF-7 breast cancer cells
tissue_expression_up	hsa-mir-155	Breast Neoplasms	26901459	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiRNA-155 was selected for being overexpressed in breast cancer
tissue_expression_up	hsa-mir-155	Breast Neoplasms	19290006	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Compared with normal breast samples, a panel of miRs was consistently dysregulated in breast cancer, including earlier-reported breast cancer-related miRs, such as upregulated miR-21, miR-155, miR-191, and miR-196a, and downregulated miR-125b and miR-221.
tissue_expression_up	hsa-mir-155	Breast Neoplasms	20388420	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The expression of miR-155 is up-regulated in primary breast cancer, especially in patients with positive estrogen and progesterone receptor.
tissue_expression_up	hsa-mir-155	Breast Neoplasms	20801493	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	A high correlation of miRNA expression level was found between breast tumor tissues and sera. MiR-21, miR-106a and miR-155 were significantly over-expressed in the tumor specimens compared with those in normal controls (P < 0.05), whereas miR-126, miR-199a and miR-335 were significantly under-expressed (P < 0.05).
tissue_expression_up	hsa-mir-17	Breast Neoplasms	16461460	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	overexpressed
tissue_expression_up	hsa-mir-181a	Breast Neoplasms	23656790	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We report that miR-181a and miR-181b were overexpressed in more aggressive breast cancers, and their expression correlates inversely with ATM levels.
tissue_expression_up	hsa-mir-181a-2	Breast Neoplasms	21271219	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Increased miR-21 and miR-181a levels were significantly associated with shortened
tissue_expression_up	hsa-mir-181a-2	Breast Neoplasms	23241956	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	TGF-beta upregulates miR-181a expression to promote breast cancer metastasis
tissue_expression_up	hsa-mir-181b	Breast Neoplasms	23656790	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We report that miR-181a and miR-181b were overexpressed in more aggressive breast cancers, and their expression correlates inversely with ATM levels.
tissue_expression_up	hsa-mir-181b-1	Breast Neoplasms	16461460	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	overexpressed
tissue_expression_up	hsa-mir-182	Breast Neoplasms	21953071	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA was up-regulated during lobular neoplasia progression compared to normal epithelium.
tissue_expression_up	hsa-mir-183	Breast Neoplasms	20331864	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	up-regulated in male breast cancer
tissue_expression_up	hsa-mir-183	Breast Neoplasms	21953071	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA was up-regulated during lobular neoplasia progression compared to normal epithelium.
tissue_expression_up	hsa-mir-18a	Breast Neoplasms	19624877	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression profiles of microRNAs between breast cancer cells and mammary epithelial cells: mir-18a and mir-195 were highly expressed in MCF-7 cells; target genes of mir-200b were predicted by informatics analysis.
tissue_expression_up	hsa-mir-18a	Breast Neoplasms	19684618	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	higher levels of expression in ERalpha-negative tumors
tissue_expression_up	hsa-mir-18b	Breast Neoplasms	23970382	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MicroRNA-18b is upregulated in breast cancer and modulates genes involved in cell migration.
tissue_expression_up	hsa-mir-190b	Breast Neoplasms	26141719	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	This study reveals miR-190b as the highest up-regulated miRNA in hormone-dependent breast cancers. Due to its specificity and high expression level, miR-190b could therefore represent a new biomarker in hormone-dependent breast cancers but its exact role carcinogenesis remains to elucidate.
tissue_expression_up	hsa-mir-191	Breast Neoplasms	19290006	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Compared with normal breast samples, a panel of miRs was consistently dysregulated in breast cancer, including earlier-reported breast cancer-related miRs, such as upregulated miR-21, miR-155, miR-191, and miR-196a, and downregulated miR-125b and miR-221.
tissue_expression_up	hsa-mir-196a	Breast Neoplasms	26062455	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MicroRNA-196a post-transcriptionally upregulates the UBE2C proto-oncogene and promotes cell proliferation in breast cancer.
tissue_expression_up	hsa-mir-196a	Breast Neoplasms	19290006	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Compared with normal breast samples, a panel of miRs was consistently dysregulated in breast cancer, including earlier-reported breast cancer-related miRs, such as upregulated miR-21, miR-155, miR-191, and miR-196a, and downregulated miR-125b and miR-221.
tissue_expression_up	hsa-mir-197	Breast Neoplasms	20331864	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	up-regulated in male breast cancer
tissue_expression_up	hsa-mir-199a-1	Breast Neoplasms	21409395	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells
tissue_expression_up	hsa-mir-199a-2	Breast Neoplasms	21409395	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells
tissue_expression_up	hsa-mir-200a	Breast Neoplasms	22294488	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer.
tissue_expression_up	hsa-mir-200b	Breast Neoplasms	19624877	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression profiles of microRNAs between breast cancer cells and mammary epithelial cells: mir-18a and mir-195 were highly expressed in MCF-7 cells; target genes of mir-200b were predicted by informatics analysis.
tissue_expression_up	hsa-mir-200b	Breast Neoplasms	22294488	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer.
tissue_expression_up	hsa-mir-200c	Breast Neoplasms	21409395	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Both miR-200c and miR-429, two members of the miR-200 family were expressed in the luminal and basal type of breast cancer in contrast to malignant myoepithelioma.
tissue_expression_up	hsa-mir-200c	Breast Neoplasms	22294488	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer.
tissue_expression_up	hsa-mir-200c	Breast Neoplasms	23185507	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-200c targets a NF-kB up-regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer
tissue_expression_up	hsa-mir-203	Breast Neoplasms	21953071	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA was up-regulated during lobular neoplasia progression compared to normal epithelium.
tissue_expression_up	hsa-mir-204	Breast Neoplasms	18922924	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-204: upregulated
tissue_expression_up	hsa-mir-206	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	mir-206 upregulated in breast cancer (Iorio et al., 2005).
tissue_expression_up	hsa-mir-20a	Breast Neoplasms	29617404	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Our results suggest a role for miR-20a in the regulation of breast cancer angiogenesis, and raise the possibility of its use as an angiogenic biomarker
tissue_expression_up	hsa-mir-21	Breast Neoplasms	25027758	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Down-regulation of miR-486-5p and miR-139-5p, in conjunction with up-regulation of miR-21, may represent a useful signature for the identification of high-risk breast cancer patients.
tissue_expression_up	hsa-mir-21	Breast Neoplasms	25337203	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Prognostic and clinicopathological significance of microRNA-21 overexpression in breast cancer: a meta-analysis.
tissue_expression_up	hsa-mir-21	Breast Neoplasms	25440114	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	the context of altered miR-21 expression provides clinically relevant information. Importantly, miR-21 expression was predominantly up-regulated and potentially prognostic in the tumor stroma of TNBC.
tissue_expression_up	hsa-mir-21	Breast Neoplasms	16103053	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	upregulation
tissue_expression_up	hsa-mir-21	Breast Neoplasms	16461460	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	overexpressed
tissue_expression_up	hsa-mir-21	Breast Neoplasms	17531469	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiR-21 is found to be highly expressed in numerous cancers like breast cancer, and glioblastoma and pancreatic cancer.
tissue_expression_up	hsa-mir-21	Breast Neoplasms	19212625	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-21: upregulated, The expression levels of miR-21 were correlated with PTEN and commonly used clinicopathologic features of breast cancer
tissue_expression_up	hsa-mir-21	Breast Neoplasms	20331864	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	up-regulated in male breast cancer
tissue_expression_up	hsa-mir-21	Breast Neoplasms	21270527	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-21, miR-210 and miR-221 were significantly overexpressed, whereas miR-10b, miR-145, miR-205, miR-122a were significantly underexpressed in the triple-negative primary breast cancers.
tissue_expression_up	hsa-mir-21	Breast Neoplasms	21271219	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Increased miR-21 and miR-181a levels were significantly associated with shortened disease-free survival(DFS; p=0.0003, 0.0007) and overall survival (OS; p=0.0351, 0.0443), respectively. Accumulation of miR-21 and miR-181a in bone marrow appears to be associated with prognosis in breast cancer patients. The much higher significant correlation with microRNA levels and prognosis suggests epistatic effects on multiple target genes in the bone marrow of breast cancer patients.
tissue_expression_up	hsa-mir-21	Breast Neoplasms	21326627	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-21 Expression in Pregnancy-Associated Breast Cancer: A Possible Marker of Poor Prognosis.
tissue_expression_up	hsa-mir-21	Breast Neoplasms	22057972	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas.
tissue_expression_up	hsa-mir-21	Breast Neoplasms	22323912	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	High miR-21 expression was associated with mastectomy, larger tumor size, higher stage, higher grade, estrogen receptor (ER) negative, human epidermal growth factor receptor 2 (HER2) positive, HER2 positive breast cancer subtype, high Ki-67 expression, and death.
tissue_expression_up	hsa-mir-21	Breast Neoplasms	22492962	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The levels of miR-10b and miR-21 are found significantly increased in the CSF (cerebrospinal fluid) of patients with glioblastoma and brain metastasis of breast and lung cancer, compared with tumors in remission and a variety of nonneoplastic conditions.
tissue_expression_up	hsa-mir-21	Breast Neoplasms	22524830	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The BC patients showed an up-regulation in miRNAs (mir-155, mir-10,mir-21 and mir-373)
tissue_expression_up	hsa-mir-21	Breast Neoplasms	22638884	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control (P < 0.001), and its sensitivity and specificity were significantly higher than the currently used tumor markers.
tissue_expression_up	hsa-mir-21	Breast Neoplasms	27082076	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	included upregulation of miR-21-5p and the miR-200 family and downregulation of let-7 family members in DCIS samples.
tissue_expression_up	hsa-mir-21	Breast Neoplasms	19290006	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Compared with normal breast samples, a panel of miRs was consistently dysregulated in breast cancer, including earlier-reported breast cancer-related miRs, such as upregulated miR-21, miR-155, miR-191, and miR-196a, and downregulated miR-125b and miR-221.
tissue_expression_up	hsa-mir-21	Breast Neoplasms	20801493	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	A high correlation of miRNA expression level was found between breast tumor tissues and sera. MiR-21, miR-106a and miR-155 were significantly over-expressed in the tumor specimens compared with those in normal controls (P < 0.05), whereas miR-126, miR-199a and miR-335 were significantly under-expressed (P < 0.05).
tissue_expression_up	hsa-mir-210	Breast Neoplasms	21270527	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-21, miR-210 and miR-221 were significantly overexpressed, whereas miR-10b, miR-145, miR-205, miR-122a were significantly underexpressed in the triple-negative primary breast cancers.
tissue_expression_up	hsa-mir-210	Breast Neoplasms	22323552	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	High Expression of MicroRNA-210 is an Independent Factor Indicating a Poor Prognosis in Japanese Triple-negative Breast Cancer Patients.
tissue_expression_up	hsa-mir-221	Breast Neoplasms	21270527	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-21, miR-210 and miR-221 were significantly overexpressed, whereas miR-10b, miR-145, miR-205, miR-122a were significantly underexpressed in the triple-negative primary breast cancers.
tissue_expression_up	hsa-mir-221	Breast Neoplasms	22964023	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)
tissue_expression_up	hsa-mir-223	Breast Neoplasms	19624877	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Differential expression profiles of microRNAs between breast cancer cells and mammary epithelial cells: mir-18a and mir-195 were highly expressed in MCF-7 cells; target genes of mir-200b were predicted by informatics analysis.
tissue_expression_up	hsa-mir-223	Breast Neoplasms	21939504	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-223, a miRNA specific for IL-4-activated macrophages, was detected within the exosomes released by macrophages and was significantly elevated in the co-cultivated SKBR3 and MDA-MB-231 cells.
tissue_expression_up	hsa-mir-24	Breast Neoplasms	25120807	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Over-expression of miR-24 and miR-378 in FFPE tissue of breast cancer patients might conduct as an ideal source for biomarker discovery and validation in breast cancer patients.
tissue_expression_up	hsa-mir-29b-1	Breast Neoplasms	16461460	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	overexpressed
tissue_expression_up	hsa-mir-301a	Breast Neoplasms	25311065	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Upregulation of miR-301a correlates with poor prognosis in triple-negative breast cancer.
tissue_expression_up	hsa-mir-302f	Breast Neoplasms	24982406	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiR-337 and miR-302f were commonly overexpressed in HER2-postive breast  and gastric cancer. MiR-139 and miR-129 were commonly underexpressed in HER2-positive breast and gastric cancer.
tissue_expression_up	hsa-mir-31	Breast Neoplasms	22057972	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas.
tissue_expression_up	hsa-mir-31	Breast Neoplasms	22964023	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)
tissue_expression_up	hsa-mir-342	Breast Neoplasms	19432961	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiR-342 expression was highest in ER and HER2/neu-positive luminal B tumours and lowest in triple-negative tumours. MiR-520g expression was elevated in ER and PR-negative tumours.
tissue_expression_up	hsa-mir-34a	Breast Neoplasms	23771315	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Synergistic effects of curcumin with emodin against the proliferation and invasion of breast cancer cells through upregulation of mir-34a.
tissue_expression_up	hsa-mir-34a	Breast Neoplasms	19684618	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	higher levels of expression in ERalpha-negative tumors
tissue_expression_up	hsa-mir-34a	Breast Neoplasms	21931769	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	ATF-126 and Maspin cDNA induction led to the re-activation of tumor suppressive miRNAs also expressed in neural cells, such as miR-1 and miR-34, and to the down-regulation of potential oncogenic miRNAs, such as miR-10b, miR-124, and miR-363.
tissue_expression_up	hsa-mir-373	Breast Neoplasms	21271679	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-373 was found to be capable of promoting breast cancer invasion and metastasis
tissue_expression_up	hsa-mir-373	Breast Neoplasms	22524830	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The BC patients showed an up-regulation in miRNAs (mir-155, mir-10,mir-21 and mir-373)
tissue_expression_up	hsa-mir-375	Breast Neoplasms	21953071	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA was up-regulated during lobular neoplasia progression compared to normal epithelium. Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity.
tissue_expression_up	hsa-mir-378a	Breast Neoplasms	25120807	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Over-expression of miR-24 and miR-378 in FFPE tissue of breast cancer patients might conduct as an ideal source for biomarker discovery and validation in breast cancer patients.
tissue_expression_up	hsa-mir-425	Breast Neoplasms	21953071	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-425-5p was up-regulated during lobular neoplasia progression compared to normal epithelium.
tissue_expression_up	hsa-mir-429	Breast Neoplasms	21409395	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Both miR-200c and miR-429, two members of the miR-200 family were expressed in the luminal and basal type of breast cancer in contrast to malignant myoepithelioma.
tissue_expression_up	hsa-mir-486	Breast Neoplasms	25027758	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Down-regulation of miR-486-5p and miR-139-5p, in conjunction with up-regulation of miR-21, may represent a useful signature for the identification of high-risk breast cancer patients.
tissue_expression_up	hsa-mir-493	Breast Neoplasms	20331864	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	up-regulated in male breast cancer
tissue_expression_up	hsa-mir-495	Breast Neoplasms	21258409	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1.
tissue_expression_up	hsa-mir-510	Breast Neoplasms	18922924	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	miR-510: upregulated
tissue_expression_up	hsa-mir-519d	Breast Neoplasms	20331864	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	up-regulated in male breast cancer
tissue_expression_up	hsa-mir-520g	Breast Neoplasms	19432961	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	MiR-342 expression was highest in ER and HER2/neu-positive luminal B tumours and lowest in triple-negative tumours. MiR-520g expression was elevated in ER and PR-negative tumours.
tissue_expression_up	hsa-mir-629	Breast Neoplasms	19946373	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	upregulated
tissue_expression_up	hsa-mir-638	Breast Neoplasms	22403704	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT
tissue_expression_up	hsa-mir-663a	Breast Neoplasms	22403704	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT
tissue_expression_up	hsa-mir-888	Breast Neoplasms	24480745	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	As a potential role in intercellular adhesiveness and maintenance of malignant tissue architecture, the results indicate that miR-888 is a repressor of the AJ pathway in MCF-7 cells and that up-regulation of miR-888 contributes to aggressiveness in MCF-7 SP cells.
tissue_expression_up	hsa-mir-9-1	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	mir-9 increased in breast cancers (Iorio et al., 2005), but downregulated in lung cancers (Yanaihara et al., 2006)
tissue_expression_up	hsa-mir-9-1	Breast Neoplasms	22294488	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer.
tissue_expression_up	hsa-mir-9-2	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	mir-9 increased in breast cancers (Iorio et al., 2005), but downregulated in lung cancers (Yanaihara et al., 2006)
tissue_expression_up	hsa-mir-9-2	Breast Neoplasms	22294488	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer.
tissue_expression_up	hsa-mir-93	Breast Neoplasms	24606013	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	These results suggest that overexpression of miR-93 in FFPE tissues may serve as an indispensable source for biomarker discovery and validation in breast cancer patients.
tissue_expression_up	hsa-mir-9-3	Breast Neoplasms	17028596	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	mir-9 increased in breast cancers (Iorio et al., 2005), but downregulated in lung cancers (Yanaihara et al., 2006)
tissue_expression_up	hsa-mir-9-3	Breast Neoplasms	22294488	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer.
tissue_expression_up	hsa-mir-98	Breast Neoplasms	24696733	thoracic disease	DOID:1612	C50	D001943	114480	HP:0100013	Over-expression of miR-98 in FFPE tissues might serve as a valuable source for biomarker discovery in breast cancer patients.
tissue_expression_up	hsa-mir-663a	Burns	22360957			M61.30	D002056			miR-663 was up-regulated in denatured dermis compared with those in normal skin.
tissue_expression_up	hsa-mir-181d	Carcinoma, Adenoid Cystic	29467480	disease of cellular proliferation	DOID:0080202		D003528			hsa-miR-455-5p and hsa-miR-181d-5p were upregulated in carcinomas of both salivary and lacrimal gland
tissue_expression_up	hsa-mir-20a	Carcinoma, Adenoid Cystic	26293217	disease of cellular proliferation	DOID:0080202		D003528			Increased expression of miR-17 and miR-20a was found in bACCs compared with bNs
tissue_expression_up	hsa-mir-455	Carcinoma, Adenoid Cystic	29467480	disease of cellular proliferation	DOID:0080202		D003528			hsa-miR-455-5p and hsa-miR-181d-5p were upregulated in carcinomas of both salivary and lacrimal gland
tissue_expression_up	hsa-let-7a-1	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	let-7a: upregulated
tissue_expression_up	hsa-let-7a-2	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	let-7a: upregulated
tissue_expression_up	hsa-let-7a-3	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	let-7a: upregulated
tissue_expression_up	hsa-let-7b	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	let-7b: upregulated
tissue_expression_up	hsa-let-7c	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	let-7c: upregulated
tissue_expression_up	hsa-let-7d	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	let-7d: upregulated
tissue_expression_up	hsa-mir-100	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-100: upregulated
tissue_expression_up	hsa-mir-1-1	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-1: upregulated
tissue_expression_up	hsa-mir-1-2	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-1: upregulated
tissue_expression_up	hsa-mir-125b-1	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-125b: upregulated
tissue_expression_up	hsa-mir-125b-2	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-125b: upregulated
tissue_expression_up	hsa-mir-126	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-126: upregulated
tissue_expression_up	hsa-mir-130a	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-130a: upregulated
tissue_expression_up	hsa-mir-132	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-132: upregulated
tissue_expression_up	hsa-mir-133a-1	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-133a: upregulated
tissue_expression_up	hsa-mir-133a-2	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-133a: upregulated
tissue_expression_up	hsa-mir-135a-1	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-135a: upregulated
tissue_expression_up	hsa-mir-135a-2	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-135a: upregulated
tissue_expression_up	hsa-mir-137	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-137: upregulated
tissue_expression_up	hsa-mir-139	Carcinoma, Adrenocortical	21471143	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	ACCs (adrenocortical carcinomas) exhibited significantly lower levels of miR-139-3p (up to 8.49-fold, p<0.001), miR-675 (up to 23.25-fold, p<0.001) and miR-335 (up to 5.25-fold, p<0.001).
tissue_expression_up	hsa-mir-143	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-143: upregulated
tissue_expression_up	hsa-mir-145	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-145: upregulated
tissue_expression_up	hsa-mir-146a	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-146a: upregulated
tissue_expression_up	hsa-mir-155	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-155: upregulated
tissue_expression_up	hsa-mir-15b	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-15b: upregulated
tissue_expression_up	hsa-mir-16-1	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-16: upregulated
tissue_expression_up	hsa-mir-16-2	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-16: upregulated
tissue_expression_up	hsa-mir-17	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-17-5p: upregulated
tissue_expression_up	hsa-mir-192	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-192: upregulated
tissue_expression_up	hsa-mir-194-1	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-194: upregulated
tissue_expression_up	hsa-mir-194-2	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-194: upregulated
tissue_expression_up	hsa-mir-200b	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-200b: upregulated
tissue_expression_up	hsa-mir-200c	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-200c: upregulated
tissue_expression_up	hsa-mir-203	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-203: upregulated
tissue_expression_up	hsa-mir-21	Carcinoma, Adrenocortical	21859927	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	Among others, miR-483-3p, miR-483-5p, miR-210, and miR-21 were found overexpressed,while miR-195, miR-497, and miR-1974 were underexpressed in ACC. 
tissue_expression_up	hsa-mir-210	Carcinoma, Adrenocortical	21859927	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	Among others, miR-483-3p, miR-483-5p, miR-210, and miR-21 were found overexpressed,while miR-195, miR-497, and miR-1974 were underexpressed in ACC. 
tissue_expression_up	hsa-mir-222	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-222: upregulated
tissue_expression_up	hsa-mir-23b	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-23b: upregulated
tissue_expression_up	hsa-mir-28	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-28: upregulated
tissue_expression_up	hsa-mir-30a	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-30a-3p: upregulated
tissue_expression_up	hsa-mir-335	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-335: upregulated
tissue_expression_up	hsa-mir-375	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-375: upregulated
tissue_expression_up	hsa-mir-375	Carcinoma, Adrenocortical	21471143	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	ACCs (adrenocortical carcinomas) exhibited significantly lower levels of miR-139-3p (up to 8.49-fold, p<0.001), miR-675 (up to 23.25-fold, p<0.001) and miR-335 (up to 5.25-fold, p<0.001).
tissue_expression_up	hsa-mir-449a	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-449: upregulated
tissue_expression_up	hsa-mir-449b	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-449: upregulated
tissue_expression_up	hsa-mir-483	Carcinoma, Adrenocortical	21472710	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miRs -100, -125b, and -195 were significantly down-regulated, whereas miR-483-5p was significantly up-regulated in malignant as compared with benign tumors.
tissue_expression_up	hsa-mir-483	Carcinoma, Adrenocortical	21859927	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	Among others, miR-483-3p, miR-483-5p, miR-210, and miR-21 were found overexpressed,while miR-195, miR-497, and miR-1974 were underexpressed in ACC. 
tissue_expression_up	hsa-mir-675	Carcinoma, Adrenocortical	21471143	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	ACCs (adrenocortical carcinomas) exhibited significantly lower levels of miR-139-3p (up to 8.49-fold, p<0.001), miR-675 (up to 23.25-fold, p<0.001) and miR-335 (up to 5.25-fold, p<0.001).
tissue_expression_up	hsa-mir-7-1	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-7: upregulated
tissue_expression_up	hsa-mir-7-2	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-7: upregulated
tissue_expression_up	hsa-mir-7-3	Carcinoma, Adrenocortical	19351815	endocrine system disease	DOID:3948		D018268	202300	HP:0006744	miR-7: upregulated
tissue_expression_up	hsa-mir-106b	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	upregulated in the tumor center
tissue_expression_up	hsa-mir-125a	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	miR-125a-5p is upregulated in the tumor center
tissue_expression_up	hsa-mir-17	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	upregulated in the tumor center
tissue_expression_up	hsa-mir-181c	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	miR-181c and miR-181c* are upregulated in the tumor center
tissue_expression_up	hsa-mir-181d	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	upregulated in the tumor center
tissue_expression_up	hsa-mir-182	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	upregulated in the tumor center
tissue_expression_up	hsa-mir-18a	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	upregulated in the tumor center
tissue_expression_up	hsa-mir-18b	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	upregulated in the tumor center
tissue_expression_up	hsa-mir-19b-1	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	miR-19b is upregulated in the tumor center
tissue_expression_up	hsa-mir-19b-2	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	miR-19b is upregulated in the tumor center
tissue_expression_up	hsa-mir-455	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	miR-455-5p and miR-455-3p are upregulated in the tumor center
tissue_expression_up	hsa-mir-542	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	miR-542 is upregulated in the tumor center
tissue_expression_up	hsa-mir-93	Carcinoma, Basal Cell	22540308	disease of cellular proliferation	DOID:2513	C44.91	D002280	605462	HP:0002671	upregulated in the tumor center
tissue_expression_up	hsa-mir-138	Carcinoma, Bladder	23946872	urinary system disease	DOID:4007	D09.0	D001749	109800	HP:0002862	Within this group, let-7b and let-7i exhibited decreased expression, while miR-1290 and miR-138 displayed increased expression levels in gemcitabine-resistant cells.
tissue_expression_up	hsa-mir-140	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies
tissue_expression_up	hsa-mir-181b	Carcinoma, Breast	21779448			D05	D001943	114480	HP:0003002	we focused on miR-181b, which was overexpressed in several malignant neoplasias including breast carcinomas. 
tissue_expression_up	hsa-mir-20b	Carcinoma, Breast	25893380			D05	D001943	114480	HP:0003002	miR-20b is up-regulated in brain metastases from primary breast cancers.
tissue_expression_up	hsa-mir-21	Carcinoma, Breast	24781337			D05	D001943	114480	HP:0003002	Higher miR-21 expression in invasive breast carcinomas is associated with positive estrogen and progesterone receptor status in patients from Serbia.
tissue_expression_up	hsa-mir-21	Carcinoma, Breast	26342497			D05	D001943	114480	HP:0003002	Chromosome 17 aneusomy and miR-21 expression are positively correlated and can potentially serve as prognostic markers in BC.
tissue_expression_up	hsa-mir-222	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies
tissue_expression_up	hsa-mir-222	Carcinoma, Breast	27746366			D05	D001943	114480	HP:0003002	MiR-222 promotes drug-resistance of breast cancer cells to adriamycin via modulation of PTEN/Akt/FOXO1 pathway.
tissue_expression_up	hsa-mir-29a	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies
tissue_expression_up	hsa-mir-3178	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies
tissue_expression_up	hsa-mir-34a	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies
tissue_expression_up	hsa-mir-423	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies
tissue_expression_up	hsa-mir-574	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies
tissue_expression_up	hsa-mir-6780b	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies
tissue_expression_up	hsa-mir-744	Carcinoma, Breast	27746365			D05	D001943	114480	HP:0003002	MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies
tissue_expression_up	hsa-let-7a	Carcinoma, Breast, Triple Negative	27404381				D064726			Interestingly, despite being a known tumor suppressor, Let-7a showed a significant overexpression in TNBCs.
tissue_expression_up	hsa-mir-155	Carcinoma, Breast, Triple Negative	26398931				D064726			These results indicate that miR-155-5p antagonizes bufalin sensitivity in TNBC cells, and that downregulation of DNMT1 and DNMT3a may be responsible for the bufalin-induced upregulation of miR-155-5p.
tissue_expression_up	hsa-mir-21	Carcinoma, Breast, Triple Negative	24930006				D064726			High expression of miR-21 in triple-negative breast cancers was correlated with a poor prognosis and promoted tumor cell in vitro proliferation.
tissue_expression_up	hsa-mir-21	Carcinoma, Breast, Triple Negative	27404381				D064726			While miR-21, miR-221 and miR-210 showed  significant over-expression, miR-195 and miR-145 were downregulated and well correlated with various clinicopathological and demographic risk factors, tumor grade, clinical stage and hormone receptor status.
tissue_expression_up	hsa-mir-210	Carcinoma, Breast, Triple Negative	27404381				D064726			While miR-21, miR-221 and miR-210 showed  significant over-expression, miR-195 and miR-145 were downregulated and well correlated with various clinicopathological and demographic risk factors, tumor grade, clinical stage and hormone receptor status.
tissue_expression_up	hsa-mir-221	Carcinoma, Breast, Triple Negative	27404381				D064726			While miR-21, miR-221 and miR-210 showed  significant over-expression, miR-195 and miR-145 were downregulated and well correlated with various clinicopathological and demographic risk factors, tumor grade, clinical stage and hormone receptor status.
tissue_expression_up	hsa-mir-126	Carcinoma, Cervical	24037526	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	Repression of miR-126 and upregulation of adrenomedullin in the stromal endothelium by cancer-stromal cross talks confers angiogenesis of cervical cancer.
tissue_expression_up	hsa-mir-196a	Carcinoma, Cervical	24817935	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	Heterogeneity of microRNAs expression in cervical cancer cells: over-expression of miR-196a.
tissue_expression_up	hsa-mir-21	Carcinoma, Cervical	26261606	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	MiR-21 upregulation is associated with aggressive progression and poor prognosis in cervical cancer, which suggests that miR-21 might be identified as an independent marker for predicting the clinical outcome of cervical cancer patients.
tissue_expression_up	hsa-mir-27a	Carcinoma, Cervical	26987623	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	B4GALT3 up-regulation by miR-27a contributes to the oncogenic activity in human cervical cancer cells.
tissue_expression_up	hsa-mir-27b	Carcinoma, Cervical	26397063	disease of cellular proliferation	DOID:2893	D06.9	D002583	603956	HP:0030159	In summary, the present study revealed that miR-27b is upregulated by HPV16 E7 to inhibit PPARγ expression and promotes proliferation and invasion in cervical carcinoma cells.
tissue_expression_up	hsa-mir-155	Carcinoma, Colon	24888652	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	The expression of miR-155 is up-regulated in colon cancer tissue. A combination of miR-155 level assay in colon cancer tissue and the serum CEA level both pre- and postoperatively can afford more accurate information for diagnosis and prognosis, especially for predicting recurrence and metastasis postoperatively.
tissue_expression_up	hsa-mir-182	Carcinoma, Colon	24053448	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells. Moreover, anti-miR-182 exerts a transcriptional regulatory mechanism of tsp-1 modulating Egr-1 and Sp-1 function. Anti-miR-182 could be used to restore TSP-1 expression in order to contrast angiogenic and invasive events in CRC.
tissue_expression_up	hsa-mir-21	Carcinoma, Colon	24122631	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	High miR-21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer.
tissue_expression_up	hsa-mir-21	Carcinoma, Colon	25569638	gastrointestinal system disease	DOID:1520	D01.0	C028885		HP:0003003	the primary tumor in colon cancer releases high concentrations of miR-21 in the MV but that these concentrations are later diluted in the circulatory system. MV expression of miR-21 may be a stronger prognostic marker than PV expression.
tissue_expression_up	hsa-mir-141	Carcinoma, Ehrlich Tumor	21899346	thoracic disease	DOID:5050		D002286			Two clusters miR-183~miR-96~miR-182 and miR-200b~miR-200a~miR-429 as well as miR-141 to be consistently up-regulated in the MDR (Multidrug resistance) cell lines, while miR-125b-5p and the two clusters miR-30d~miR-30b and miR-23b~miR-27b~miR-24-1 were down-regulated in most of the resistant EAT (Ehrlich ascites tumor) cells.
tissue_expression_up	hsa-mir-182	Carcinoma, Ehrlich Tumor	21899346	thoracic disease	DOID:5050		D002286			Two clusters miR-183~miR-96~miR-182 and miR-200b~miR-200a~miR-429 as well as miR-141 to be consistently up-regulated in the MDR (Multidrug resistance) cell lines, while miR-125b-5p and the two clusters miR-30d~miR-30b and miR-23b~miR-27b~miR-24-1 were down-regulated in most of the resistant EAT (Ehrlich ascites tumor) cells.
tissue_expression_up	hsa-mir-183	Carcinoma, Ehrlich Tumor	21899346	thoracic disease	DOID:5050		D002286			Two clusters miR-183~miR-96~miR-182 and miR-200b~miR-200a~miR-429 as well as miR-141 to be consistently up-regulated in the MDR (Multidrug resistance) cell lines, while miR-125b-5p and the two clusters miR-30d~miR-30b and miR-23b~miR-27b~miR-24-1 were down-regulated in most of the resistant EAT (Ehrlich ascites tumor) cells.
tissue_expression_up	hsa-mir-200a	Carcinoma, Ehrlich Tumor	21899346	thoracic disease	DOID:5050		D002286			Two clusters miR-183~miR-96~miR-182 and miR-200b~miR-200a~miR-429 as well as miR-141 to be consistently up-regulated in the MDR (Multidrug resistance) cell lines, while miR-125b-5p and the two clusters miR-30d~miR-30b and miR-23b~miR-27b~miR-24-1 were down-regulated in most of the resistant EAT (Ehrlich ascites tumor) cells.
tissue_expression_up	hsa-mir-200b	Carcinoma, Ehrlich Tumor	21899346	thoracic disease	DOID:5050		D002286			Two clusters miR-183~miR-96~miR-182 and miR-200b~miR-200a~miR-429 as well as miR-141 to be consistently up-regulated in the MDR (Multidrug resistance) cell lines, while miR-125b-5p and the two clusters miR-30d~miR-30b and miR-23b~miR-27b~miR-24-1 were down-regulated in most of the resistant EAT (Ehrlich ascites tumor) cells.
tissue_expression_up	hsa-mir-429	Carcinoma, Ehrlich Tumor	21899346	thoracic disease	DOID:5050		D002286			Two clusters miR-183~miR-96~miR-182 and miR-200b~miR-200a~miR-429 as well as miR-141 to be consistently up-regulated in the MDR (Multidrug resistance) cell lines, while miR-125b-5p and the two clusters miR-30d~miR-30b and miR-23b~miR-27b~miR-24-1 were down-regulated in most of the resistant EAT (Ehrlich ascites tumor) cells.
tissue_expression_up	hsa-mir-96	Carcinoma, Ehrlich Tumor	21899346	thoracic disease	DOID:5050		D002286			Two clusters miR-183~miR-96~miR-182 and miR-200b~miR-200a~miR-429 as well as miR-141 to be consistently up-regulated in the MDR (Multidrug resistance) cell lines, while miR-125b-5p and the two clusters miR-30d~miR-30b and miR-23b~miR-27b~miR-24-1 were down-regulated in most of the resistant EAT (Ehrlich ascites tumor) cells.
tissue_expression_up	hsa-mir-141	Carcinoma, Endometrial	26045795	reproductive system disease	DOID:2871	D07.0	D016889	608089	HP:0012114	miR-200a/miR-141 and miR-205 upregulation might be associated with hormone receptor status and prognosis in endometrial carcinomas.
tissue_expression_up	hsa-mir-155	Carcinoma, Endometrial	21125666	reproductive system disease	DOID:2871	D07.0	D016889	608089	HP:0012114	Up-regulated miRNAs included miR-155, miR-369-5p, miR-370, miR-450a and miR-542-5p. These data suggest that in human ECS, the interplay between transcriptional repressors of E-cadherin and miRNAs provides a link between EMT-activation and the maintenance of stemness.
tissue_expression_up	hsa-mir-200a	Carcinoma, Endometrial	26045795	reproductive system disease	DOID:2871	D07.0	D016889	608089	HP:0012114	miR-200a/miR-141 and miR-205 upregulation might be associated with hormone receptor status and prognosis in endometrial carcinomas.
tissue_expression_up	hsa-mir-205	Carcinoma, Endometrial	26045795	reproductive system disease	DOID:2871	D07.0	D016889	608089	HP:0012114	miR-200a/miR-141 and miR-205 upregulation might be associated with hormone receptor status and prognosis in endometrial carcinomas.
tissue_expression_up	hsa-mir-369	Carcinoma, Endometrial	21125666	reproductive system disease	DOID:2871	D07.0	D016889	608089	HP:0012114	Up-regulated miRNAs included miR-155, miR-369-5p, miR-370, miR-450a and miR-542-5p. These data suggest that in human ECS, the interplay between transcriptional repressors of E-cadherin and miRNAs provides a link between EMT-activation and the maintenance of stemness.
tissue_expression_up	hsa-mir-450a	Carcinoma, Endometrial	21125666	reproductive system disease	DOID:2871	D07.0	D016889	608089	HP:0012114	Up-regulated miRNAs included miR-155, miR-369-5p, miR-370, miR-450a and miR-542-5p. These data suggest that in human ECS, the interplay between transcriptional repressors of E-cadherin and miRNAs provides a link between EMT-activation and the maintenance of stemness.
tissue_expression_up	hsa-mir-542	Carcinoma, Endometrial	21125666	reproductive system disease	DOID:2871	D07.0	D016889	608089	HP:0012114	Up-regulated miRNAs included miR-155, miR-369-5p, miR-370, miR-450a and miR-542-5p. These data suggest that in human ECS, the interplay between transcriptional repressors of E-cadherin and miRNAs provides a link between EMT-activation and the maintenance of stemness.
tissue_expression_up	hsa-mir-135b	Carcinoma, Endometrioid Endometrial	24491411			C54.1	D018269			Quantitative reverse-transcriptase PCR identified 8 EEC-associated miRNAs in tissue (upregulated: miR-499, miR-135b, miR-205, downregulated: miR-10b, miR-195, miR-30a-5p, miR-30a-3p and miR-21).
tissue_expression_up	hsa-mir-141	Carcinoma, Endometrioid Endometrial	21035172			C54.1	D018269			A miRNA microarray showed that the miR-200 family, including hsa-miR-141, hsa-miR-200a, hsa-miR-200b, hsa-miR-200c, and hsa-miR-429, was up-regulated in EECs as compared with that in normal endometrial tissues.
tissue_expression_up	hsa-mir-200a	Carcinoma, Endometrioid Endometrial	21035172			C54.1	D018269			A miRNA microarray showed that the miR-200 family, including hsa-miR-141, hsa-miR-200a, hsa-miR-200b, hsa-miR-200c, and hsa-miR-429, was up-regulated in EECs as compared with that in normal endometrial tissues.
tissue_expression_up	hsa-mir-200b	Carcinoma, Endometrioid Endometrial	21035172			C54.1	D018269			A miRNA microarray showed that the miR-200 family, including hsa-miR-141, hsa-miR-200a, hsa-miR-200b, hsa-miR-200c, and hsa-miR-429, was up-regulated in EECs as compared with that in normal endometrial tissues.
tissue_expression_up	hsa-mir-200c	Carcinoma, Endometrioid Endometrial	21035172			C54.1	D018269			A miRNA microarray showed that the miR-200 family, including hsa-miR-141, hsa-miR-200a, hsa-miR-200b, hsa-miR-200c, and hsa-miR-429, was up-regulated in EECs as compared with that in normal endometrial tissues.
tissue_expression_up	hsa-mir-429	Carcinoma, Endometrioid Endometrial	21035172			C54.1	D018269			These results indicate that the miR-200 family is highly expressed in EECs compared with that of normal endometrial tissues and could play an important role in cancer growth. Specifically, anti-miR-429 could enhance the cytotoxic activity with cisplatin in EECs.
tissue_expression_up	hsa-mir-198	Carcinoma, Esophageal	24175778	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	miR-198 overexpression is involved in the poor prognosis of esophageal cancer and can be used as a biomarker for selection of cases requiring especial attention.
tissue_expression_up	hsa-mir-21	Carcinoma, Esophageal	24756761	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	Nicotine upregulates microRNA-21 and promotes TGF-β-dependent epithelial-mesenchymal transition of esophageal cancer cells.
tissue_expression_up	hsa-mir-503	Carcinoma, Esophageal	25750296	disease of cellular proliferation	DOID:1107	C15.9	D004938	133239	HP:0011459	High miR-503 expression was identified as an independent prognostic predictor in patients with EC according to multivariate analysis
tissue_expression_up	hsa-let-7a	Carcinoma, Gastric	28399984	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	Up-regulation of Let-7a Expression Induces Gastric Carcinoma Cell Apoptosis In Vitro.
tissue_expression_up	hsa-mir-124	Carcinoma, Gastric	26109806	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	Paeoniflorin inhibits human gastric carcinoma cell proliferation through up-regulation of microRNA-124 and suppression of PI3K/Akt and STAT3 signaling.
tissue_expression_up	hsa-mir-16	Carcinoma, Gastric	27605261	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	High expression of miR-16 and miR-451 predicating better prognosis in patients with gastric cancer.
tissue_expression_up	hsa-mir-222	Carcinoma, Gastric	27994199	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	Upregulation of miR-222 in both Helicobacter pylori- infected and noninfected gastric cancer patients.
tissue_expression_up	hsa-mir-451	Carcinoma, Gastric	27605261	disease of cellular proliferation	DOID:5517	C16.9	D013274		HP:0012126	High expression of miR-16 and miR-451 predicating better prognosis in patients with gastric cancer.
tissue_expression_up	hsa-mir-223	Carcinoma, Gastrooesophageal	28395057							Early miR-223 Upregulation in Gastroesophageal Carcinogenesis.
tissue_expression_up	hsa-mir-31	Carcinoma, Gingival	25126847			D00.03				Expression of hsa-miR-31 was significantly up-regulated in both cancer and leukoplakia tissues and, thus, may  be one of the molecular markers of leukoplakia which may progress to gingivo-buccal cancer.
tissue_expression_up	hsa-let-7a-1	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-let-7a-2	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-let-7a-3	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-100	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-100: overexpressed In HCC patients with hepatitis C and liver cirrhosis
tissue_expression_up	hsa-mir-100	Carcinoma, Hepatocellular	18307259	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-122, miR-100, and miR-10a were overexpressed whereas miR-198 and miR-145 were up to 5-fold down-regulated in hepatic tumors compared to normal liver parenchyma.
tissue_expression_up	hsa-mir-105-1	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-105-2	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-106a	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-106b	Carcinoma, Hepatocellular	25466449	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-106b expression was significantly upregulated in HCC and could serve as a potential unfavorable prognostic biomarker.
tissue_expression_up	hsa-mir-106b	Carcinoma, Hepatocellular	27298561	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	The value of miR-106b expression in HBV-associated HCC patients was significantly higher
tissue_expression_up	hsa-mir-10a	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-10a: overexpressed In HCC patients with hepatitis C and liver cirrhosis
tissue_expression_up	hsa-mir-10a	Carcinoma, Hepatocellular	18307259	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-122, miR-100, and miR-10a were overexpressed whereas miR-198 and miR-145 were up to 5-fold down-regulated in hepatic tumors compared to normal liver parenchyma.
tissue_expression_up	hsa-mir-10b	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-10b	Carcinoma, Hepatocellular	29314614	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-1, miR-122, let-7a, and let-7g were downregulated, whereas miR-10b and miR-21 were upregulated in canine HCC
tissue_expression_up	hsa-mir-122	Carcinoma, Hepatocellular	22213236	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	up-regulated in HCC tissues.correlated with cirrhosis
tissue_expression_up	hsa-mir-122	Carcinoma, Hepatocellular	18307259	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-122, miR-100, and miR-10a were overexpressed whereas miR-198 and miR-145 were up to 5-fold down-regulated in hepatic tumors compared to normal liver parenchyma.
tissue_expression_up	hsa-mir-1224	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-1224-3p was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_up	hsa-mir-1234	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-1234 was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_up	hsa-mir-1249	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-1249 was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_up	hsa-mir-126	Carcinoma, Hepatocellular	20619223	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-126:hsa-miR-126 showed higher expression levels in hepatocellular carcinomas
tissue_expression_up	hsa-mir-126	Carcinoma, Hepatocellular	18433021	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-96 was overexpressed in HBV tumors, and miR-126* was down-regulated in alcohol-related hepatocellular carcinoma.
tissue_expression_up	hsa-mir-128a	Carcinoma, Hepatocellular	25345933	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-128a is up-regulated in HCC and promotes HCC cell proliferation by targeting RND3.
tissue_expression_up	hsa-mir-137	Carcinoma, Hepatocellular	28350139	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Upregulation of miR-137 reverses sorafenib resistance and cancer-initiating cell phenotypes by degrading ANT2 in hepatocellular carcinoma.
tissue_expression_up	hsa-mir-146a	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-148b	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-151a	Carcinoma, Hepatocellular	21319996	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-30d and miR-151 were amplified in ~50% of Hepatitis B Virus-Associated HCC tumor tissues
tissue_expression_up	hsa-mir-155	Carcinoma, Hepatocellular	21762537	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	ectopic expression of miR-155 upregulated the expression of several IFN-inducible antivirus genes in human hepatoma cells.
tissue_expression_up	hsa-mir-155	Carcinoma, Hepatocellular	22629365	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	High expression levels of miR-155, miR-15a, miR-432, miR-486-3p, miR-15b and miR-30b were significantly associated with recurrence-free.
tissue_expression_up	hsa-mir-155	Carcinoma, Hepatocellular	23863669	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MicroRNA-155 is over-expressed in primary HCC with tumor recurrence and may serve as a novel biomarker for tumor recurrence and survival of HCC patients after LT. The detection of microRNA-155 is of clinical significance in HCC.
tissue_expression_up	hsa-mir-15a	Carcinoma, Hepatocellular	22629365	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	High expression levels of miR-155, miR-15a, miR-432, miR-486-3p, miR-15b and miR-30b were significantly associated with recurrence-free.
tissue_expression_up	hsa-mir-15b	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-15b* was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_up	hsa-mir-15b	Carcinoma, Hepatocellular	22629365	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	High expression levels of miR-155, miR-15a, miR-432, miR-486-3p, miR-15b and miR-30b were significantly associated with recurrence-free.
tissue_expression_up	hsa-mir-17	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-17	Carcinoma, Hepatocellular	22583011	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-17-5p was significantly upregulated in HCCs. HCC with metastasis had higher miR-17-5p levels than that without metastasis.
tissue_expression_up	hsa-mir-182	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-183	Carcinoma, Hepatocellular	20602797	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Among the 25 HCC samples analyzed, microRNA-183 was significantly up-regulated (twofold to 367-fold) in 17 samples compared with the matching nontumoral liver tissues.
tissue_expression_up	hsa-mir-183	Carcinoma, Hepatocellular	26640336	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miRNA-183 was the most up-regulated, followed by miRNA-373. miRNA-129 and miRNA-188 were both strongly down-regulated and miRNA-378 was down-regulated a small amount.
tissue_expression_up	hsa-mir-18a	Carcinoma, Hepatocellular	16331254	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	upregulated
tissue_expression_up	hsa-mir-18b	Carcinoma, Hepatocellular	16331254	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	upregulated
tissue_expression_up	hsa-mir-193a	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-196a-1	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-196a-2	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-197	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-197 was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_up	hsa-mir-199a-1	Carcinoma, Hepatocellular	23319430	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Propofol induces apoptosis of hepatocellular carcinoma cells by upregulation of microRNA-199a expression
tissue_expression_up	hsa-mir-199a-2	Carcinoma, Hepatocellular	23319430	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Propofol induces apoptosis of hepatocellular carcinoma cells by upregulation of microRNA-199a expression
tissue_expression_up	hsa-mir-203	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-203: up-regulated in HCC compared to benign hepatocellular tumors
tissue_expression_up	hsa-mir-205	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-20a	Carcinoma, Hepatocellular	16331254	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	overexpression
tissue_expression_up	hsa-mir-20b	Carcinoma, Hepatocellular	16331254	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	overexpression
tissue_expression_up	hsa-mir-21	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-21: up-regulated in HCC compared to benign hepatocellular tumors
tissue_expression_up	hsa-mir-21	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-21	Carcinoma, Hepatocellular	22213236	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	up-regulated in HCC tissues.correlated with cirrhosis;associated with tumor stage and poor prognosis.
tissue_expression_up	hsa-mir-21	Carcinoma, Hepatocellular	26436398	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	We concluded that miR-21 might be complementary to alpha fetal protein in HCC diagnosis, and might serve as an attractive estimator of HCC. We also demonstrated that miR-21 overexpression was associated with HCC TNM stage and with poor survival.
tissue_expression_up	hsa-mir-21	Carcinoma, Hepatocellular	26261620	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Our results suggested that increased expression of miR-21 was significantly correlated with tumor progression and could be a novel potential biomarker for HCC prognosis.
tissue_expression_up	hsa-mir-21	Carcinoma, Hepatocellular	29314614	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-1, miR-122, let-7a, and let-7g were downregulated, whereas miR-10b and miR-21 were upregulated in canine HCC
tissue_expression_up	hsa-mir-210	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-214	Carcinoma, Hepatocellular	29088870	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	high miR-214 could be a promising biomarker for prognosis prediction of cancer
tissue_expression_up	hsa-mir-217	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-217	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_up	hsa-mir-221	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-221: up-regulated in HCC compared to benign hepatocellular tumors
tissue_expression_up	hsa-mir-221	Carcinoma, Hepatocellular	19585654	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	critical player; up-regulated; could directly target hepatic transcriptional regulators of differentiation and an inhibitor of Wnt/beta-catenin signaling
tissue_expression_up	hsa-mir-221	Carcinoma, Hepatocellular	21458843	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Deregulated expression of microRNA-221 with the potential for prognostic biomarkers in surgically resected hepatocellular carcinoma.
tissue_expression_up	hsa-mir-221	Carcinoma, Hepatocellular	22213236	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	up-regulated in HCC tissues.correlated with cirrhosis;associated with tumor stage and poor prognosis.
tissue_expression_up	hsa-mir-221	Carcinoma, Hepatocellular	23320393	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Increased MiR-221 expression in hepatocellular carcinoma tissues and its role in enhancing cell growth and inhibiting apoptosis in vitro
tissue_expression_up	hsa-mir-221	Carcinoma, Hepatocellular	26258795	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MiR-221 and miR-222 (miR-221/222) are well-studied oncogenic microRNAs that are frequently upregulated in several types of human tumors
tissue_expression_up	hsa-mir-222	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-222: up-regulated in HCC compared to benign hepatocellular tumors
tissue_expression_up	hsa-mir-222	Carcinoma, Hepatocellular	20103675	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	overexpression
tissue_expression_up	hsa-mir-222	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-222	Carcinoma, Hepatocellular	22213236	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	up-regulated in HCC tissues.
tissue_expression_up	hsa-mir-222	Carcinoma, Hepatocellular	24124720	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Serum miR-222, upregulated in HCC, maybe helpful in prognosis of HCC patients.
tissue_expression_up	hsa-mir-224	Carcinoma, Hepatocellular	16331254	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	upregulated
tissue_expression_up	hsa-mir-224	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-224: up-regulated in HCC compared to benign hepatocellular tumors
tissue_expression_up	hsa-mir-224	Carcinoma, Hepatocellular	24923856	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	These results indicate for the first time that miR-224 upregulation and AKT activation may synergistically associate with tumor progression of HCC.The combined high expression of miR-224 and pAKT may be a potential indicator for predicting unfavorable prognosis in HCC patients.
tissue_expression_up	hsa-mir-25	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-25	Carcinoma, Hepatocellular	24593846	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Our data suggests that the overexpression of miR-25 in HCC tissues is of predictive value on poor prognosis.
tissue_expression_up	hsa-mir-29a	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-302b	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-302c	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-30a	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-30b	Carcinoma, Hepatocellular	22629365	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	High expression levels of miR-155, miR-15a, miR-432, miR-486-3p, miR-15b and miR-30b were significantly associated with recurrence-free.
tissue_expression_up	hsa-mir-30d	Carcinoma, Hepatocellular	21319996	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-30d and miR-151 were amplified in ~50% of Hepatitis B Virus-Associated HCC tumor tissues
tissue_expression_up	hsa-mir-31	Carcinoma, Hepatocellular	22213236	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	up-regulated in HCC tissues.correlated with cirrhosis
tissue_expression_up	hsa-mir-34a	Carcinoma, Hepatocellular	19360909	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	miR-34a: up-regulated in HCC compared to benign hepatocellular tumors
tissue_expression_up	hsa-mir-34c	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-372	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-372	Carcinoma, Hepatocellular	23291979	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Upregulation of microRNA-372 associates with tumor progression and prognosis in hepatocellular carcinoma
tissue_expression_up	hsa-mir-376a-1	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-376a-2	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-379	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-432	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-432	Carcinoma, Hepatocellular	22629365	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	High expression levels of miR-155, miR-15a, miR-432, miR-486-3p, miR-15b and miR-30b were significantly associated with recurrence-free.
tissue_expression_up	hsa-mir-449b	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-449b* was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_up	hsa-mir-450a-1	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-450a-2	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-450b	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-486	Carcinoma, Hepatocellular	22629365	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	High expression levels of miR-155, miR-15a, miR-432, miR-486-3p, miR-15b and miR-30b were significantly associated with recurrence-free.
tissue_expression_up	hsa-mir-493	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-508	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-512	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_up	hsa-mir-517c	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-517c	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_up	hsa-mir-518a	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_up	hsa-mir-518b	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_up	hsa-mir-518e	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_up	hsa-mir-519a	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_up	hsa-mir-519e	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-520g	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_up	hsa-mir-522	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-522 was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_up	hsa-mir-522	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_up	hsa-mir-525	Carcinoma, Hepatocellular	23082062	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. 
tissue_expression_up	hsa-mir-532	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-532-3p was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_up	hsa-mir-675	Carcinoma, Hepatocellular	23864307	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Expression of the miR-675 in hepatocellular carcinoma links a dramatic upregulation of proliferative and growth capacity with inhibition of motility in HCC cells.
tissue_expression_up	hsa-mir-744	Carcinoma, Hepatocellular	21998738	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	hsa-mir-744* was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract.
tissue_expression_up	hsa-mir-761	Carcinoma, Hepatocellular	26845057	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	MicroRNA-761 is upregulated in hepatocellular carcinoma and regulates tumorigenesis by targeting Mitofusin-2.
tissue_expression_up	hsa-mir-888	Carcinoma, Hepatocellular	28337887	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	Up-regulation of miR-888-5p in hepatocellular carcinoma cell lines and its effect on malignant characteristics of cells.
tissue_expression_up	hsa-mir-9	Carcinoma, Hepatocellular	28774651	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	inhibition of hsa_circ_0071410 increased the expression of miR-9-5p, resulting in the attenuation of irradiation induced HSC activation
tissue_expression_up	hsa-mir-92a-1	Carcinoma, Hepatocellular	16331254	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	overexpression
tissue_expression_up	hsa-mir-92a-2	Carcinoma, Hepatocellular	16331254	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	overexpression
tissue_expression_up	hsa-mir-92b	Carcinoma, Hepatocellular	16331254	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	overexpression
tissue_expression_up	hsa-mir-96	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-98	Carcinoma, Hepatocellular	22027761	disease of cellular proliferation	DOID:684	C22.0	D006528	114550	HP:0001402	This miRNA was up-regulated in HepG2 cells treated with BJA32515.
tissue_expression_up	hsa-mir-155	Carcinoma, Lung, Non-Small-Cell	23099007			C34.90	D002289		HP:0030358	High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer.
tissue_expression_up	hsa-mir-181b	Carcinoma, Lung, Non-Small-Cell	27291819			C34.90	D002289		HP:0030358	miR-181b-5p was up-regulated in squamous cell carcinoma
tissue_expression_up	hsa-mir-205	Carcinoma, Lung, Non-Small-Cell	20068099			C34.90	D002289		HP:0030358	hsa-miR-205 is a miRNA that is highly expressed in lung squamous cell carcinomas (SqCC) but not in lung adenocarcinomas.
tissue_expression_up	hsa-mir-205	Carcinoma, Lung, Non-Small-Cell	23207443			C34.90	D002289		HP:0030358	SQCC was distinguished from normal tissue and ADC by high-level miR-205 expression and decreased miR-26b.
tissue_expression_up	hsa-mir-21	Carcinoma, Lung, Non-Small-Cell	19446359			C34.90	D002289		HP:0030358	Mir-21 expression in the sputum specimens was significantly higher in cancer patients (76.32+/-9.79) than cancer-free individuals (62.24+/-3.82) (P<0.0001).
tissue_expression_up	hsa-mir-21	Carcinoma, Lung, Non-Small-Cell	23099007			C34.90	D002289		HP:0030358	High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer.
tissue_expression_up	hsa-mir-21	Carcinoma, Lung, Non-Small-Cell	27072269			C34.90	D002289		HP:0030358	miR-15a/16, miR-34a, miR-126 and miR-128 were down-regulated significantly. (>2-fold change), while miR-21 and miR.210 were up-regulated in A549.
tissue_expression_up	hsa-mir-210	Carcinoma, Lung, Non-Small-Cell	25384507			C34.90	D002289		HP:0030358	At the same time, miR-21 and miR-210 were upregulated by 53.3 and 66.6% in cancer tissue versus matched adjacent normal tissues, respectively.
tissue_expression_up	hsa-mir-210	Carcinoma, Lung, Non-Small-Cell	27072269			C34.90	D002289		HP:0030358	miR-15a/16, miR-34a, miR-126 and miR-128 were down-regulated significantly. (>2-fold change), while miR-21 and miR.210 were up-regulated in A549.
tissue_expression_up	hsa-mir-221	Carcinoma, Lung, Non-Small-Cell	26831656			C34.90	D002289		HP:0030358	The relative expression levels of microRNA-221 in the pathological  tissues were remarkably higher than that in the corresponding normal tissues
tissue_expression_up	hsa-mir-543	Carcinoma, Lung, Non-Small-Cell	27769862			C34.90	D002289		HP:0030358	miR-543 is up-regulated in gefitinib-resistant non-small cell lung cancer and promotes cell proliferation and invasion via phosphatase and tensin homolog.
tissue_expression_up	hsa-let-7b	Carcinoma, Lung, Non-Small-Cell	21622546			C34.90	D002289		HP:0030358	Eighteen cases were classified as AD and 13 as SCC by light microscopy and immunocytochemistry. miRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens
tissue_expression_up	hsa-let-7c	Carcinoma, Lung, Non-Small-Cell	21622546			C34.90	D002289		HP:0030358	Eighteen cases were classified as AD and 13 as SCC by light microscopy and immunocytochemistry. miRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens
tissue_expression_up	hsa-let-7f	Carcinoma, Lung, Non-Small-Cell	21622546			C34.90	D002289		HP:0030358	Eighteen cases were classified as AD and 13 as SCC by light microscopy and immunocytochemistry. miRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens
tissue_expression_up	hsa-let-7g	Carcinoma, Lung, Non-Small-Cell	21622546			C34.90	D002289		HP:0030358	Eighteen cases were classified as AD and 13 as SCC by light microscopy and immunocytochemistry. miRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens
tissue_expression_up	hsa-let-7i	Carcinoma, Lung, Non-Small-Cell	21622546			C34.90	D002289		HP:0030358	Eighteen cases were classified as AD and 13 as SCC by light microscopy and immunocytochemistry. miRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens
tissue_expression_up	hsa-mir-126	Carcinoma, Lung, Non-Small-Cell	21264844			C34.90	D002289		HP:0030358	Independent and tissue-specific prognostic impact of miR-126 in nonsmall cell lung cancer: Coexpression with vascular endothelial growth factor-A predicts poor survival.
tissue_expression_up	hsa-mir-1280	Carcinoma, Lung, Non-Small-Cell	25698202			C34.90	D002289		HP:0030358	The miR-1280 expression was significantly higher in the NSCLC tissues than distal normal tissues
tissue_expression_up	hsa-mir-141	Carcinoma, Lung, Non-Small-Cell	25003366			C34.90	D002289		HP:0030358	High miR-141 and miR-200c expression are associated with shorter OS in NSCLC patients with adenocarcinoma through MET and angiogenesis.
tissue_expression_up	hsa-mir-146	Carcinoma, Lung, Non-Small-Cell	24448024			C34.90	D002289		HP:0030358	microRNA-146 up-regulation predicts the prognosis of non-small cell lung cancer by miRNA in situ hybridization.
tissue_expression_up	hsa-mir-150	Carcinoma, Lung, Non-Small-Cell	25755784			C34.90	D002289		HP:0030358	Our data indicated that overexpression of miR-150 in NSCLC tissues has prognostic value.
tissue_expression_up	hsa-mir-155	Carcinoma, Lung, Non-Small-Cell	24854560			C34.90	D002289		HP:0030358	High expression of miR-155 represents a valuable marker of poor clinical outcomes in patients with stage III NSCLC.
tissue_expression_up	hsa-mir-16-1	Carcinoma, Lung, Non-Small-Cell	21400525			C34.90	D002289		HP:0030358	miR-16 levels in tumor samples may be a prognostic marker in NSCLC.
tissue_expression_up	hsa-mir-16-2	Carcinoma, Lung, Non-Small-Cell	21400525			C34.90	D002289		HP:0030358	miR-16 levels in tumor samples may be a prognostic marker in NSCLC.
tissue_expression_up	hsa-mir-182	Carcinoma, Lung, Non-Small-Cell	24575749			C34.90	D002289		HP:0030358	In patients with SCC and in stage II patients, high tumor cell miR-182 expression is an independent positive prognostic factor.
tissue_expression_up	hsa-mir-200c	Carcinoma, Lung, Non-Small-Cell	25003366			C34.90	D002289		HP:0030358	High miR-141 and miR-200c expression are associated with shorter OS in NSCLC patients with adenocarcinoma through MET and angiogenesis.
tissue_expression_up	hsa-mir-205	Carcinoma, Lung, Non-Small-Cell	18719201			C34.90	D002289		HP:0030358	miR-205: overexpression
tissue_expression_up	hsa-mir-21	Carcinoma, Lung, Non-Small-Cell	18719201			C34.90	D002289		HP:0030358	miR-21: overexpression
tissue_expression_up	hsa-mir-21	Carcinoma, Lung, Non-Small-Cell	24293118			C34.90	D002289		HP:0030358	Our data suggest a novel molecular mechanism in which inhibition of microRNA-21 and upregulation of PTEN mediate the anticancer activities of curcumin in NSCLC cells. Suppression of microRNA-21 may thus have therapeutic benefits against this malignancy.
tissue_expression_up	hsa-mir-21	Carcinoma, Lung, Non-Small-Cell	26563758			C34.90	D002289		HP:0030358	Higher expression levels of miR-21, AmiR-27a, and miR-218 detected in this study suggest potential roles of these miRNAs in primary resistance to EGFR-TKI in advanced NSCLC patients with EGFR exon 19 deletion mutations. These findings need to be further confirmed in a study with a larger sample size.
tissue_expression_up	hsa-mir-34a	Carcinoma, Lung, Non-Small-Cell	22438124			C34.90	D002289		HP:0030358	Delta-tocotrienol suppresses Notch-1 pathway by up-regulating miR-34a in non-small cell lung cancer cells.
tissue_expression_up	hsa-mir-708	Carcinoma, Lung, Non-Small-Cell	22573352			C34.90	D002289		HP:0030358	Increased miR-708 expression in NSCLC and its association with poor survival in lung adenocarcinoma from never smokers.
tissue_expression_up	hsa-mir-96	Carcinoma, Lung, Non-Small-Cell	22046296			C34.90	D002289		HP:0030358	hsa-mir-96 is significantly and consistently up-regulated in all 6 NSCLCs.
tissue_expression_up	hsa-mir-98	Carcinoma, Lung, Non-Small-Cell	21622546			C34.90	D002289		HP:0030358	Eighteen cases were classified as AD and 13 as SCC by light microscopy and immunocytochemistry. miRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens
tissue_expression_up	hsa-mir-375	Carcinoma, Lung, Small-Cell	22172490			C34.90	D055752	182280	HP:0030357	miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells.
tissue_expression_up	hsa-mir-10b	Carcinoma, Nasopharyngeal	27186392	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	we show that microRNA-10b (miR-10b) is up-regulated in HNE1/DDP cells
tissue_expression_up	hsa-mir-143	Carcinoma, Nasopharyngeal	28105209	disease of cellular proliferation	DOID:9261	C11	C538339	607107	HP:0100630	Upregulated microRNA-143 inhibits cell proliferation in human nasopharyngeal carcinoma.
tissue_expression_up	hsa-mir-155	Carcinoma, Neuroendocrine	22924844	disease of cellular proliferation	DOID:1800	C7A	D018278		HP:0100634	The expression levels of miR-21 and miR-155 were significantly higher in high-grade NE carcinomas (LCNECs and SCLCs) than in carcinoid tumors (TCs and ACs) (each P < 0.001). The expression level of miR-21 in carcinoid tumors with lymph node metastasis was significantly higher than in carcinoid tumors without lymph node metastasis (P= 0.010).
tissue_expression_up	hsa-mir-21	Carcinoma, Neuroendocrine	22924844	disease of cellular proliferation	DOID:1800	C7A	D018278		HP:0100634	The expression levels of miR-21 and miR-155 were significantly higher in high-grade NE carcinomas (LCNECs and SCLCs) than in carcinoid tumors (TCs and ACs) (each P < 0.001). The expression level of miR-21 in carcinoid tumors with lymph node metastasis was significantly higher than in carcinoid tumors without lymph node metastasis (P= 0.010).
tissue_expression_up	hsa-mir-31	Carcinoma, Oral	22083872	gastrointestinal system disease	DOID:0050610					Salivary miR-31 was significantly increased in patients with oral carcinoma at all clinical stages, including very small tumors. However, our preliminary analysis showed no increase of salivary miR-31in patients with oral verrucous leukoplakia relative to controls. The miR-31 was more abundant in saliva than in plasma, suggesting salivary miR-31 was a more sensitive marker for oral malignancy. After excision of oral carcinoma, salivary miR-31 was remarkably reduced, indicating that most of the upregulated salivary miR-31 came from tumor tissues.
tissue_expression_up	hsa-mir-372	Carcinoma, Oral	26152520	gastrointestinal system disease	DOID:0050610					Upregulation of miR-372 and -373 associates with lymph node metastasis and poor prognosis of oral carcinomas.
tissue_expression_up	hsa-mir-373	Carcinoma, Oral	26152520	gastrointestinal system disease	DOID:0050610					Upregulation of miR-372 and -373 associates with lymph node metastasis and poor prognosis of oral carcinomas.
tissue_expression_up	hsa-mir-145	Carcinoma, Ovarian	29569698	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	miRNA-145 expression was lower in DPEEOC endometrial tissues and higher in DPEEOC ovarian tissues compared to the corresponding normal tissues
tissue_expression_up	hsa-mir-25	Carcinoma, Ovarian	24696291	endocrine system disease	DOID:4001	C56.9	C538090	167000	HP:0025318	The increased expression of miR-25 is closely related to poor prognosis of EOC, indicating that miR-25 may serve as a predictive biomarker for the prognosis of EOC.
tissue_expression_up	hsa-mir-126	Carcinoma, Ovarian, Clear Cell	27612152	endocrine system disease	DOID:0050934					MicroRNA Gene Expression Signature Driven by miR-9 Overexpression in Ovarian Clear Cell Carcinoma.
tissue_expression_up	hsa-mir-9	Carcinoma, Ovarian, Clear Cell	27612152	endocrine system disease	DOID:0050934					MicroRNA Gene Expression Signature Driven by miR-9 Overexpression in Ovarian Clear Cell Carcinoma.
tissue_expression_up	hsa-let-7f	Carcinoma, Pancreatic	18665421			C25.3	C562463	260350	HP:0002894	In addition, when analyzed according to specific cancer phenotypes, miR-15a and miR-16 show a significant downregulation in canine ductal carcinomas while miRsR-181b, -21, -29b, and let-7f show a significant upregulation in canine tubular papillary carcinomas.
tissue_expression_up	hsa-mir-181b	Carcinoma, Pancreatic	18665421			C25.3	C562463	260350	HP:0002894	In addition, when analyzed according to specific cancer phenotypes, miR-15a and miR-16 show a significant downregulation in canine ductal carcinomas while miRsR-181b, -21, -29b, and let-7f show a significant upregulation in canine tubular papillary carcinomas.
tissue_expression_up	hsa-mir-21	Carcinoma, Pancreatic	18665421			C25.3	C562463	260350	HP:0002894	In addition, when analyzed according to specific cancer phenotypes, miR-15a and miR-16 show a significant downregulation in canine ductal carcinomas while miRsR-181b, -21, -29b, and let-7f show a significant upregulation in canine tubular papillary carcinomas.
tissue_expression_up	hsa-mir-29b	Carcinoma, Pancreatic	18665421			C25.3	C562463	260350	HP:0002894	In addition, when analyzed according to specific cancer phenotypes, miR-15a and miR-16 show a significant downregulation in canine ductal carcinomas while miRsR-181b, -21, -29b, and let-7f show a significant upregulation in canine tubular papillary carcinomas.
tissue_expression_up	hsa-mir-106a	Carcinoma, Rectal	21671476	disease of cellular proliferation	DOID:1993	C20	D012004			One of the most up-regulated miRNAs, miRNA-106a, was consistently reported to be differentially expressed in six studies and the five most down-regulated miRNAs, miR-30a-3p, miR-139, miR-145, miR-125a and miR-133a, were consistently reported to be differentially expressed in four studies.
tissue_expression_up	hsa-mir-143	Carcinoma, Rectal	17553685	disease of cellular proliferation	DOID:1993	C20	D012004			Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells.
tissue_expression_up	hsa-mir-21	Carcinoma, Rectal	18196926	disease of cellular proliferation	DOID:1993	C20	D012004			Expression levels of analyzed miRNAs significantly differed among tumors and adjacent non-tumor tissues: miR-21 (p = 0.0001) and miR-31 (p = 0.0006) were upregulated, and miR-143 (p = 0.011) and miR-145 (p = 0.003) were downregulated in tumors.
tissue_expression_up	hsa-mir-21	Carcinoma, Rectal	20551304	disease of cellular proliferation	DOID:1993	C20	D012004			miRNA expression profiles from 29 patients showed higher expression of miR-21 and miR-106a in patients with adenomas and CRCs compared with individuals free of colorectal neoplasia.
tissue_expression_up	hsa-mir-31	Carcinoma, Rectal	18196926	disease of cellular proliferation	DOID:1993	C20	D012004			Expression levels of analyzed miRNAs significantly differed among tumors and adjacent non-tumor tissues: miR-21 (p = 0.0001) and miR-31 (p = 0.0006) were upregulated, and miR-143 (p = 0.011) and miR-145 (p = 0.003) were downregulated in tumors.
tissue_expression_up	hsa-mir-122	Carcinoma, Renal Cell	21784468	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Overexpression
tissue_expression_up	hsa-mir-122	Carcinoma, Renal Cell	24175769	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	The up-regulation of miR-122 may play an important role in the progress of renal cancer through activating PI3K/Akt signal pathway and could be a potential molecular target for anti-cancer therapeutics.
tissue_expression_up	hsa-mir-142	Carcinoma, Renal Cell	29440068	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-21, miR-142-3p, miR-142-5p, miR-150, and miR-155 as significantly upregulated
tissue_expression_up	hsa-mir-150	Carcinoma, Renal Cell	29440068	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-21, miR-142-3p, miR-142-5p, miR-150, and miR-155 as significantly upregulated
tissue_expression_up	hsa-mir-155	Carcinoma, Renal Cell	19228262	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-155: overexpressed in malignant cancer than non-malignant one
tissue_expression_up	hsa-mir-155	Carcinoma, Renal Cell	21784468	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Overexpression
tissue_expression_up	hsa-mir-155	Carcinoma, Renal Cell	29440068	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-21, miR-142-3p, miR-142-5p, miR-150, and miR-155 as significantly upregulated
tissue_expression_up	hsa-mir-16-1	Carcinoma, Renal Cell	19228262	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-16: overexpressed in malignant cancer than non-malignant one
tissue_expression_up	hsa-mir-16-2	Carcinoma, Renal Cell	19228262	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-16: overexpressed in malignant cancer than non-malignant one
tissue_expression_up	hsa-mir-185	Carcinoma, Renal Cell	25217984	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Elevated microRNA-185 is associated with high vascular endothelial growth factor receptor 2 expression levels and high microvessel density in clear cell renal cell carcinoma.
tissue_expression_up	hsa-mir-200c	Carcinoma, Renal Cell	25860934	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Loss of miR-200c up-regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma.
tissue_expression_up	hsa-mir-21	Carcinoma, Renal Cell	28184919	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Upregulation of miR-21 expression is a valuable predicator of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma through the p53/p21‑cyclin E2‑Bax/caspase-3 signaling pathway.
tissue_expression_up	hsa-mir-21	Carcinoma, Renal Cell	29440068	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-21, miR-142-3p, miR-142-5p, miR-150, and miR-155 as significantly upregulated
tissue_expression_up	hsa-mir-210	Carcinoma, Renal Cell	19228262	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-210: overexpressed in malignant cancer than non-malignant one
tissue_expression_up	hsa-mir-210	Carcinoma, Renal Cell	21465485	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Overexpression of miR-210, a downstream target of HIF1, causes centrosome amplification in renal carcinoma cells.
tissue_expression_up	hsa-mir-210	Carcinoma, Renal Cell	21784468	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	Overexpression
tissue_expression_up	hsa-mir-210	Carcinoma, Renal Cell	22043236	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	For miR-92a, and a striking inverse correlation with VHL mRNA levels was found. For the hypoxia-regulated miR-210, clear cell tumors showed significantly higher expression levels when compared to tumor of non-clear cell histology (9.90-fold vs. 1.36, p<0.001).
tissue_expression_up	hsa-mir-224	Carcinoma, Renal Cell	19228262	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-224: overexpressed in malignant cancer than non-malignant one
tissue_expression_up	hsa-mir-605	Carcinoma, Renal Cell	28222071	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-605 is elevated at baseline in the Responders and is downregulated with treatment in Responders as compared with Progressors
tissue_expression_up	hsa-mir-452	Carcinoma, Renal Cell	19228262	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	miR-452*: overexpressed in malignant cancer than non-malignant one
tissue_expression_up	hsa-mir-92a-1	Carcinoma, Renal Cell	22043236	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	For miR-92a, and a striking inverse correlation with VHL mRNA levels was found. For the hypoxia-regulated miR-210, clear cell tumors showed significantly higher expression levels when compared to tumor of non-clear cell histology (9.90-fold vs. 1.36, p<0.001).
tissue_expression_up	hsa-mir-92a-2	Carcinoma, Renal Cell	22043236	disease of cellular proliferation	DOID:4450		D002292	144700	HP:0005584	For miR-92a, and a striking inverse correlation with VHL mRNA levels was found. For the hypoxia-regulated miR-210, clear cell tumors showed significantly higher expression levels when compared to tumor of non-clear cell histology (9.90-fold vs. 1.36, p<0.001).
tissue_expression_up	hsa-mir-210	Carcinoma, Renal Cell, Clear-Cell	26670229	disease of cellular proliferation	DOID:4467				HP:0006770	miR-21-5p and miR-210-3p resulted the most significantly up-regulated miRNAs in this patient cohort
tissue_expression_up	hsa-mir-221	Carcinoma, Renal Cell, Clear-Cell	27427222	disease of cellular proliferation	DOID:4467				HP:0006770	miRNA-21 and miRNA-221 expressions were significantly up-regulated in tumor specimens compared to normal tissue (P<0.05).
tissue_expression_up	hsa-mir-21	Carcinoma, Skin	28069514	disease of cellular proliferation	DOID:3451	D04.9	D018280		HP:0008069	Increased microRNA 21 expression contributes to arsenic induced skin lesions, skin cancers and respiratory distress in chronically exposed individuals.
tissue_expression_up	hsa-mir-146a	Carcinoma, Thyroid	25524940	disease of cellular proliferation	DOID:3963	C73	D013964	188550	HP:0002890	Up-regulation of miR-146a and miR-146b expression in tissues was related to carcinogenesis and deterioration of PTC. MicroRNA-146a and miR-146b expressed in thyroid tissue may act as potential biomarkers for PTC patients.
tissue_expression_up	hsa-mir-146b	Carcinoma, Thyroid	25524940	disease of cellular proliferation	DOID:3963	C73	D013964	188550	HP:0002890	Up-regulation of miR-146a and miR-146b expression in tissues was related to carcinogenesis and deterioration of PTC. MicroRNA-146a and miR-146b expressed in thyroid tissue may act as potential biomarkers for PTC patients.
tissue_expression_up	hsa-mir-146b	Carcinoma, Thyroid	27347103	disease of cellular proliferation	DOID:3963	C73	D013964	188550	HP:0002890	the expression levels of miR146b, miR221 and miR222 were significantly higher
tissue_expression_up	hsa-mir-221	Carcinoma, Thyroid	27347103	disease of cellular proliferation	DOID:3963	C73	D013964	188550	HP:0002890	the expression levels of miR146b, miR221 and miR222 were significantly higher
tissue_expression_up	hsa-mir-146a	Carcinoma, Thyroid, Anaplastic	20061417			C73	D065646	188550	HP:0011779	Nuclear factor-{kappa}B contributes to anaplastic thyroid carcinomas through up-regulation of miR-146a.
tissue_expression_up	hsa-mir-375	Carcinoma, Thyroid, Follicular	26818914	disease of cellular proliferation	DOID:3962	C73	C572845	188470	HP:0006731	Only miR-375 was over-expressed in the FNs diagnosed as carcinomas and in the PMs.
tissue_expression_up	hsa-mir-375	Carcinoma, Thyroid, Follicular	29683529	disease of cellular proliferation	DOID:3962	C73	C572845	188470	HP:0006731	High expression values of MirR-375 provided 100% ROM
tissue_expression_up	hsa-mir-183	Carcinoma, Thyroid, Medullary	29388012	disease of cellular proliferation	DOID:3973	C73	C536914	155240	HP:0002865	Tumour expression levels of miR-21 (p=0.0008) and miR-183 (p=0.0096) were higher in the LNI group
tissue_expression_up	hsa-mir-21	Carcinoma, Thyroid, Medullary	29107050	disease of cellular proliferation	DOID:3973	C73	C536914	155240	HP:0002865	MicroRNA-21 and long non-coding RNA MALAT1 are overexpressed markers in medullary thyroid carcinoma.
tissue_expression_up	hsa-mir-21	Carcinoma, Thyroid, Medullary	29388012	disease of cellular proliferation	DOID:3973	C73	C536914	155240	HP:0002865	Tumour expression levels of miR-21 (p=0.0008) and miR-183 (p=0.0097) were higher in the LNI group
tissue_expression_up	hsa-mir-146a	Carcinoma, Thyroid, Papillary	26003825	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Our results demonstrate that down-regulation of THRβ is a common feature of PTCs. While it is not associated with a more aggressive phenotype of PTC, it correlates with the reduction of all the markers of differentiation and is associated with overexpression of some miRNAs supposed to play a role in thyroid tumorigenesis.
tissue_expression_up	hsa-mir-146b	Carcinoma, Thyroid, Papillary	23427895	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Fourteen miRNAs were deregulated in FVPTC with a fold change of more than five (up/down), including miRNAs known to be upregulated in PTC (miR-146b-3p, -146-5p, -221, -222 and miR-222-5p) and novel miRNAs (miR-375, -551b, 181-2-3p, 99b-3p).
tissue_expression_up	hsa-mir-146b	Carcinoma, Thyroid, Papillary	23569392	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	In addition, the miR-146b expression level was significantly higher in the massive extrathyroidal invasion group than in the minimal extrathyroidal invasion group
tissue_expression_up	hsa-mir-21	Carcinoma, Thyroid, Papillary	26003825	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Our results demonstrate that down-regulation of THRβ is a common feature of PTCs. While it is not associated with a more aggressive phenotype of PTC, it correlates with the reduction of all the markers of differentiation and is associated with overexpression of some miRNAs supposed to play a role in thyroid tumorigenesis.
tissue_expression_up	hsa-mir-221	Carcinoma, Thyroid, Papillary	16365291	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	upregulation
tissue_expression_up	hsa-mir-221	Carcinoma, Thyroid, Papillary	16728577	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	upregulation
tissue_expression_up	hsa-mir-221	Carcinoma, Thyroid, Papillary	26003825	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Our results demonstrate that down-regulation of THRβ is a common feature of PTCs. While it is not associated with a more aggressive phenotype of PTC, it correlates with the reduction of all the markers of differentiation and is associated with overexpression of some miRNAs supposed to play a role in thyroid tumorigenesis.
tissue_expression_up	hsa-mir-221	Carcinoma, Thyroid, Papillary	19030936	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Primary or mature miR-221 were overexpressed in PTC as compared with HT-ori3.
tissue_expression_up	hsa-mir-221	Carcinoma, Thyroid, Papillary	23427895	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Fourteen miRNAs were deregulated in FVPTC with a fold change of more than five (up/down), including miRNAs known to be upregulated in PTC (miR-146b-3p, -146-5p, -221, -222 and miR-222-5p) and novel miRNAs (miR-375, -551b, 181-2-3p, 99b-3p).
tissue_expression_up	hsa-mir-222	Carcinoma, Thyroid, Papillary	16728577	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	upregulation
tissue_expression_up	hsa-mir-222	Carcinoma, Thyroid, Papillary	23427895	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Fourteen miRNAs were deregulated in FVPTC with a fold change of more than five (up/down), including miRNAs known to be upregulated in PTC (miR-146b-3p, -146-5p, -221, -222 and miR-222-5p) and novel miRNAs (miR-375, -551b, 181-2-3p, 99b-3p).
tissue_expression_up	hsa-mir-31	Carcinoma, Thyroid, Papillary	26380656	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	miR-21, miR-146b, miR-221, miR-222, miR-31, and miR-3613 were up-regulated
tissue_expression_up	hsa-mir-595	Carcinoma, Thyroid, Papillary	27022736	disease of cellular proliferation	DOID:3969	C73	C536915	188550	HP:0002895	Interestingly, in PTC cell lines and PTC tissues, expression of IL-22 and miR-595 was upregulated and Sox17  downregulated compared with normal thyroid
tissue_expression_up	hsa-mir-372	Carcinoma, Urothelial	27351382	disease of cellular proliferation	DOID:4006				HP:0030409	high primary tumour levels of E2F1, miR-21 and miR-372 are associated with poor PFS independent of clinical prognostic factors.
tissue_expression_up	hsa-mir-208a	Cardiomegaly	19726871			I51.7	D006332		HP:0001640	overexpression
tissue_expression_up	hsa-mir-133a	Cardiomyopathy, Dilated	27292200	cardiovascular system disease	DOID:12930	I42.0	D002311	115200	HP:0001644	Endomyocardial  expression of miR-155 and miR-133a, as quantified by reverse transcription-PCR (RT-PCR), was up-regulated in patients with iCMP as compared with patients with DCM.
tissue_expression_up	hsa-mir-208	Cardiomyopathy, Dilated	20447577	cardiovascular system disease	DOID:12930	I42.0	D002311	115200	HP:0001644	Levels of miR-208, miR-208b, and miR-499 were higher in DCM patients than in controls.
tissue_expression_up	hsa-mir-208b	Cardiomyopathy, Dilated	20447577	cardiovascular system disease	DOID:12930	I42.0	D002311	115200	HP:0001644	Levels of miR-208, miR-208b, and miR-499 were higher in DCM patients than in controls.
tissue_expression_up	hsa-mir-21	Cardiomyopathy, Dilated	22041329	cardiovascular system disease	DOID:12930	I42.0	D002311	115200	HP:0001644	Levels of let-7i, miR-126, and miR-155 were lower in the DCM group than in the controls, whereas levels of miR-21 and TLR4 (both mRNA and protein) were higher in the DCM group than in the control group. Levels of let-7i were negatively correlated with TLR4 protein levels in all subjects. After a mean follow-up period of 509 days, 6 DCM patients (5.8%) had died due to a cardiac cause and 15 (14.6%) had developed heart failure. When patients with DCM were divided into tertiles according to let-7i levels, log-rank analysis showed that the DCM subgroup with low let-7i levels was associated with poor clinical outcomes (P = .02).
tissue_expression_up	hsa-mir-499	Cardiomyopathy, Dilated	20447577	cardiovascular system disease	DOID:12930	I42.0	D002311	115200	HP:0001644	Levels of miR-208, miR-208b, and miR-499 were higher in DCM patients than in controls.
tissue_expression_up	hsa-mir-133a-1	Cardiomyopathy, Hypertrophic	21893044	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	Hydrogen sulphide inhibits cardiomyocyte hypertrophy by up-regulating miR-133a.
tissue_expression_up	hsa-mir-133a-2	Cardiomyopathy, Hypertrophic	21893044	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	Hydrogen sulphide inhibits cardiomyocyte hypertrophy by up-regulating miR-133a.
tissue_expression_up	hsa-mir-195	Cardiomyopathy, Hypertrophic	17108080	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	miR-23a, miR-23b, miR-24, miR-195, and miR-214, all of which were up-regulated during cardiac hypertrophy, appeared to be capable of inducing hypertrophic growth in vitro.
tissue_expression_up	hsa-mir-199a-1	Cardiomyopathy, Hypertrophic	17108080	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	overexpressed
tissue_expression_up	hsa-mir-199a-2	Cardiomyopathy, Hypertrophic	17108080	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	overexpressed
tissue_expression_up	hsa-mir-214	Cardiomyopathy, Hypertrophic	17108080	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	overexpressed
tissue_expression_up	hsa-mir-23a	Cardiomyopathy, Hypertrophic	17108080	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	miR-23a, miR-23b, miR-24, miR-195, and miR-214, all of which were up-regulated during cardiac hypertrophy, appeared to be capable of inducing hypertrophic growth in vitro.
tissue_expression_up	hsa-mir-23b	Cardiomyopathy, Hypertrophic	17108080	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	miR-23a, miR-23b, miR-24, miR-195, and miR-214, all of which were up-regulated during cardiac hypertrophy, appeared to be capable of inducing hypertrophic growth in vitro.
tissue_expression_up	hsa-mir-24-1	Cardiomyopathy, Hypertrophic	17108080	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	miR-23a, miR-23b, miR-24, miR-195, and miR-214, all of which were up-regulated during cardiac hypertrophy, appeared to be capable of inducing hypertrophic growth in vitro.
tissue_expression_up	hsa-mir-24-2	Cardiomyopathy, Hypertrophic	17108080	cardiovascular system disease	DOID:11984	I42.2	D002312	192600	HP:0001639	miR-23a, miR-23b, miR-24, miR-195, and miR-214, all of which were up-regulated during cardiac hypertrophy, appeared to be capable of inducing hypertrophic growth in vitro.
tissue_expression_up	hsa-mir-4423	Cardiotoxicity	26842497				D066126			early deregulation of miR-187-3p, miR-182-5p, miR-486-3p, miR-486-5p, miR-34a-3p, miR-4423-3p, miR-34c-3p, miR-34c-5p and miR-1303, and also the prolonged up-regulation of miR-182-5p, miR-4423-3p and miR-34c-5p.
tissue_expression_up	hsa-mir-195	Cardiovascular Diseases [unspecific]	25339460				D002318			The cardiac dysfunction of the rat with selenium deficiency was mainly associated with five upregulated miRNAs, which were miR-374, miR-16, miR-199a-5p, miR-195 and miR-30e*, and three downregulated  miRNAs, which were miR-3571, miR-675 and miR-450a*.
tissue_expression_up	hsa-mir-21	Cardiovascular Diseases [unspecific]	26342092				D002318			MiR-146b-5p, -146a, -21, -150, -155, -299-5p are overexpressed in the presence of inflammation in TABs from patients with GCA.
tissue_expression_up	hsa-mir-34a	Cardiovascular Diseases [unspecific]	26446137				D002318			overexpression of miR-34a was significantly associated with increased apoptosis, impaired cell vitality and aggravated senescence.
tissue_expression_up	hsa-mir-15a	Cataract	25932180	nervous system disease	DOID:83	H26.9	D002386	PS116200	HP:0000518	hsa-miR-15a-5p, hsa-miR-15a-3p, and hsa-miR-16-1-5p were expressed at low levels  in normal lens epithelial cells but at significantly higher levels in corresponding cells of patients
tissue_expression_up	hsa-mir-210	Cerebral Ischemia	27386874	cardiovascular system disease	DOID:2316	I67.82	D002545		HP:0002637	miR-210 expression in the hippocampus of the I/R group at 6, 24 and 96 h after reperfusion was significantly increased at each time point, while its  expression in the group treated with HRS was significantly decreased.
tissue_expression_up	hsa-mir-21	Cervical Neoplasms	27278606	disease of cellular proliferation	DOID:4362	C53.9	D002583	603956	HP:0030159	the expression of miR-21 was upregulated and the expression of miR-143 was downregulated by the HPV16 E7 oncoprotein in vivo
tissue_expression_up	hsa-mir-21	Cervical Neoplasms	29487007	disease of cellular proliferation	DOID:4362	C53.9	D002583	603956	HP:0030159	MiR-21-5p upregulation, miR-34a downregulation, and hTERC amplification were associated with the aggressive progression of CC, which suggests that miR-21-5p, miR-34a and hTERC might serve as surrogate markers for CC progression and potential molecular targets for blockage of the development of CC
tissue_expression_up	hsa-mir-21	Cervical Neoplasms	22997891	disease of cellular proliferation	DOID:4362	C53.9	D002583	603956	HP:0030159	The high expression of miR-21 in cervical cancer and Hela cell indicate that it may play a possible role of oncogenes, while miR-143 and miR-373 with low expression may play the role of tumor suppressor genes.
tissue_expression_up	hsa-mir-425	Cervical Neoplasms	27166306	disease of cellular proliferation	DOID:4362	C53.9	D002583	603956	HP:0030159	miR-425-5p is up-regulated in cervical cancer and serum miR-425-5p may serve as a potential prognostic biomarker for cervical cancer.
tissue_expression_up	hsa-mir-9	Cervical Neoplasms	27345415	disease of cellular proliferation	DOID:4362	C53.9	D002583	603956	HP:0030159	MiR-9 up-regulated in cervical cancer
tissue_expression_up	hsa-mir-141	Cholangiocarcinoma	16762633	disease of cellular proliferation	DOID:4947	C22.1	D018281	615619	HP:0030153	MiR-21, miR-141, and miR-200b were highly over-expressed in malignant cholangiocytes.
tissue_expression_up	hsa-mir-200b	Cholangiocarcinoma	16762633	disease of cellular proliferation	DOID:4947	C22.1	D018281	615619	HP:0030153	MiR-21, miR-141, and miR-200b were highly over-expressed in malignant cholangiocytes.
tissue_expression_up	hsa-mir-21	Cholangiocarcinoma	17531469	disease of cellular proliferation	DOID:4947	C22.1	D018281	615619	HP:0030153	Recently Meng et al. showed that miR-21 is also overexpressed in malignant cholangiocarcinomas, a highly chemoresistant cancer type, knockdown of miR-21 sensitised cholangiocarcinoma cell lines for treatment with gemcitabin, whereas transfection of non-malignant cholangiocytes with precursor miR-21 made cells more resistant to gemcitabin.
tissue_expression_up	hsa-mir-21	Cholangiocarcinoma	19296468	disease of cellular proliferation	DOID:4947	C22.1	D018281	615619	HP:0030153	miR-21: overexpressed
tissue_expression_up	hsa-mir-21	Cholangiocarcinoma	16762633	disease of cellular proliferation	DOID:4947	C22.1	D018281	615619	HP:0030153	MiR-21, miR-141, and miR-200b were highly over-expressed in malignant cholangiocytes.
tissue_expression_up	hsa-let-7a-1	Cholesteatoma	22289526	integumentary system disease	DOID:869	H71.9	D002781	604183	HP:0009797	Levels of miR-21 and let-7a microRNA were significantly higher in cholesteatoma tissue compared with normal skin, especially in paediatric patients.
tissue_expression_up	hsa-let-7a-2	Cholesteatoma	22289526	integumentary system disease	DOID:869	H71.9	D002781	604183	HP:0009797	Levels of miR-21 and let-7a microRNA were significantly higher in cholesteatoma tissue compared with normal skin, especially in paediatric patients.
tissue_expression_up	hsa-let-7a-3	Cholesteatoma	22289526	integumentary system disease	DOID:869	H71.9	D002781	604183	HP:0009797	Levels of miR-21 and let-7a microRNA were significantly higher in cholesteatoma tissue compared with normal skin, especially in paediatric patients.
tissue_expression_up	hsa-mir-21	Cholesteatoma	22289526	integumentary system disease	DOID:869	H71.9	D002781	604183	HP:0009797	Levels of miR-21 and let-7a microRNA were significantly higher in cholesteatoma tissue compared with normal skin, especially in paediatric patients.
tissue_expression_up	hsa-mir-221	Cholesteatoma	19672202	integumentary system disease	DOID:869	H71.9	D002781	604183	HP:0009797	up-regulated concurrent with down-regulation of PTEN
tissue_expression_up	hsa-mir-141	Chondrosarcoma	24992595	disease of cellular proliferation	DOID:3371	M91-M94	D002813	215300	HP:0006765	Paeonol suppresses chondrosarcoma metastasis through up-regulation of miR-141 by modulating PKCδ and c-Src signaling pathway.
tissue_expression_up	hsa-mir-518b	Chondrosarcoma	24173143	disease of cellular proliferation	DOID:3371	M91-M94	D002813	215300	HP:0006765	Gallic acid induces apoptosis and inhibits cell migration by upregulating miR-518b in SW1353 human chondrosarcoma cells.
tissue_expression_up	hsa-mir-223	Chorioamnionitis	29083107	reproductive system disease	DOID:0050697	41.129	D002821			Increased miR-223 expression in foetal organs is a signature of acute chorioamnionitis with systemic consequences.
tissue_expression_up	hsa-mir-143	Choriocarcinoma	27374102	disease of cellular proliferation	DOID:3594	C58	D002822		HP:0100768	miR-143, miR-145, miR-194 and miR-215 levels were significantly higher
tissue_expression_up	hsa-mir-205	Choriocarcinoma	26711784	disease of cellular proliferation	DOID:3594	C58	D002822		HP:0100768	we observed significantly higher levels of miR-205 in tumor tissue of esophageal squamous cell carcinoma
tissue_expression_up	hsa-mir-21	Choriocarcinoma	26807210	disease of cellular proliferation	DOID:3594	C58	D002822		HP:0100768	the expression of miR-200b, miR-200c, miR-451, miR-223 and miR-21 were significantly upregulated in mucinous cystadenocarcinoma
tissue_expression_up	hsa-mir-221	Choriocarcinoma	26258795	disease of cellular proliferation	DOID:3594	C58	D002822		HP:0100768	MiR-221 and miR-222 (miR-221/222) are well-studied oncogenic microRNAs that are frequently upregulated in several types of human tumors
tissue_expression_up	hsa-mir-223	Choriocarcinoma	26807210	disease of cellular proliferation	DOID:3594	C58	D002822		HP:0100768	the expression of miR-200b, miR-200c, miR-451, miR-223 and miR-21 were significantly upregulated in mucinous cystadenocarcinoma
tissue_expression_up	hsa-mir-31	Choriocarcinoma	23946296	disease of cellular proliferation	DOID:3594	C58	D002822		HP:0100768	MicroRNA-31 predicts the presence of lymph node metastases and survival in patients with lung adenocarcinoma.
tissue_expression_up	hsa-mir-130a	Chronic Alcohol-Induced Alveolar Macrophage Dysfunction	26677910							Alcohol increased levels of microRNA-130a/-301a, these findings demonstrate that targeting PPARγ provides a novel therapeutic approach for mitigating alcohol-induced AM derangements and susceptibility to lung infection
tissue_expression_up	hsa-mir-301a	Chronic Alcohol-Induced Alveolar Macrophage Dysfunction	26677910							Alcohol increased levels of microRNA-130a/-301a, these findings demonstrate that targeting PPARγ provides a novel therapeutic approach for mitigating alcohol-induced AM derangements and susceptibility to lung infection
tissue_expression_up	hsa-mir-150	Chronic Heart Failure	24239242	cardiovascular system disease	DOID:6000	I50	D006333		HP:0001635	MicroRNA-150 counteracts ADIPOR2 up-regulation in CHF and thus may contribute to adiponectin resistance. Targeting microRNA-150 may be a future strategy to restore cardioprotective adiponectin effects.
tissue_expression_up	hsa-mir-143	Chronic Hepatitis	24993656			K75.9	D006521		HP:0200123	In conclusion, the expression of miR-143 and miR-215 in serum were significantly up-regulated in patients with chronic hepatitis and HCC. Due to its reasonable sensitivity and specificity for both diseases, miR-143 and miR-215 could be as potential circulating biomarkers.
tissue_expression_up	hsa-mir-215	Chronic Hepatitis	24993656			K75.9	D006521		HP:0200123	In conclusion, the expression of miR-143 and miR-215 in serum were significantly up-regulated in patients with chronic hepatitis and HCC. Due to its reasonable sensitivity and specificity for both diseases, miR-143 and miR-215 could be as potential circulating biomarkers.
tissue_expression_up	hsa-let-7b	Chronic Inflammation	27539004							PM2.5 exposure increased miR-3560 and let-7b-5p in the hippocampus, two proteins that regulate genes Oxct1 and Lin28b that control ketogenesis and glycosylation, and neural cell differentiation, respectively
tissue_expression_up	hsa-mir-3560	Chronic Inflammation	27539004							PM2.5 exposure increased miR-3560 and let-7b-5p in the hippocampus, two proteins that regulate genes Oxct1 and Lin28b that control ketogenesis and glycosylation, and neural cell differentiation, respectively
tissue_expression_up	hsa-mir-3588	Chronic Inflammation	27539004							Expression levels of cortical miR-6315, miR-3588, and miR-466b-5p were upregulated
tissue_expression_up	hsa-mir-466b	Chronic Inflammation	27539004							Expression levels of cortical miR-6315, miR-3588, and miR-466b-5p were upregulated
tissue_expression_up	hsa-mir-6315	Chronic Inflammation	27539004							Expression levels of cortical miR-6315, miR-3588, and miR-466b-5p were upregulated
tissue_expression_up	hsa-mir-199a-1	Chronic Obstructive Pulmonary Disease	22383663	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	miR-34a and miR-199a-5p expression was increased and the phosphorylation of AKT was decreased in COPD lungs. The miR-199a-5p expression was correlated with HIF-1ж┿protein expression in COPD patient's lungs. Transfection of HPMVEC with the miR-199a-5p precursor gene decreased HIF-1ж┿protein expression, and transfection with the miR-34a precursor gene increased miR-199a-5p expression.
tissue_expression_up	hsa-mir-34a	Chronic Obstructive Pulmonary Disease	22383663	respiratory system disease	DOID:3083	J44.9	D029424	606963	HP:0006510	miR-34a and miR-199a-5p expression was increased and the phosphorylation of AKT was decreased in COPD lungs. The miR-199a-5p expression was correlated with HIF-1ж┿protein expression in COPD patient's lungs. Transfection of HPMVEC with the miR-199a-5p precursor gene decreased HIF-1ж┿protein expression, and transfection with the miR-34a precursor gene increased miR-199a-5p expression.
tissue_expression_up	hsa-mir-155	Colitis, Ulcerative	20586854	gastrointestinal system disease	DOID:8577	K51	D003093			miR-155:Upregulated miRNA may be responsible for the development of intestinal inflammation in UC
tissue_expression_up	hsa-mir-21	Colitis, Ulcerative	20586854	gastrointestinal system disease	DOID:8577	K51	D003093			miR-21:Upregulated miRNA may be responsible for the development of intestinal inflammation in UC
tissue_expression_up	hsa-let-7f	Colon Neoplasms	26556872			D12.6	D003110		HP:0100273	highly up-regulated miRNAs, let-7f-5p, miR-455-3p, miR-98, miR-155-5p and the down-regulated miRNAs, miR-1, miR-127-5p, miR-142-5p, miR-202-5p were associated with colon cancer pathways
tissue_expression_up	hsa-mir-101	Colon Neoplasms	28560419			D12.6	D003110		HP:0100273	Upregulation of miR-101 enhances the cytotoxic effect of anticancer drugs through inhibition of colon cancer cell proliferation.
tissue_expression_up	hsa-mir-101	Colon Neoplasms	22043014			D12.6	D003110		HP:0100273	The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)
tissue_expression_up	hsa-mir-106a	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-106a	Colon Neoplasms	20551304			D12.6	D003110		HP:0100273	miRNA expression profiles from 29 patients showed higher expression of miR-21 and miR-106a in patients with adenomas and CRCs compared with individuals free of colorectal neoplasia.
tissue_expression_up	hsa-mir-106b	Colon Neoplasms	20132431			D12.6	D003110		HP:0100273	A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control.
tissue_expression_up	hsa-mir-107	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-128-2	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-128a	Colon Neoplasms	22898888			D12.6	D003110		HP:0100273	in colonic fibroblasts p38 was only moderately activated, p53 as well as p16 expressions were upregulated in the presence of increased expression of miR-34a, miR-128a and miR-449a.
tissue_expression_up	hsa-mir-135b	Colon Neoplasms	20132431			D12.6	D003110		HP:0100273	A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control.
tissue_expression_up	hsa-mir-137	Colon Neoplasms	19659786			D12.6	D003110		HP:0100273	expressed differently, miR-137 upregulated in non-cancerous colonic tissues from colon cancer patients with lymph node metastasis
tissue_expression_up	hsa-mir-142	Colon Neoplasms	22043014			D12.6	D003110		HP:0100273	The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)
tissue_expression_up	hsa-mir-146a	Colon Neoplasms	22043014			D12.6	D003110		HP:0100273	The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)
tissue_expression_up	hsa-mir-155	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-155	Colon Neoplasms	24989910			D12.6	D003110		HP:0100273	The level of miR-155 was gradually elevated with the formation of colitis-associated  colon cancer.
tissue_expression_up	hsa-mir-155	Colon Neoplasms	26556872			D12.6	D003110		HP:0100273	highly up-regulated miRNAs, let-7f-5p, miR-455-3p, miR-98, miR-155-5p and the down-regulated miRNAs, miR-1, miR-127-5p, miR-142-5p, miR-202-5p were associated with colon cancer pathways
tissue_expression_up	hsa-mir-155	Colon Neoplasms	22043014			D12.6	D003110		HP:0100273	The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)
tissue_expression_up	hsa-mir-17	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-18a	Colon Neoplasms	23229340			D12.6	D003110		HP:0100273	MicroRNA-18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells
tissue_expression_up	hsa-mir-18a	Colon Neoplasms	20132431			D12.6	D003110		HP:0100273	A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control.
tissue_expression_up	hsa-mir-18b	Colon Neoplasms	20132431			D12.6	D003110		HP:0100273	A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control.
tissue_expression_up	hsa-mir-191	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-192	Colon Neoplasms	22180714			D12.6	D003110		HP:0100273	Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc.
tissue_expression_up	hsa-mir-194	Colon Neoplasms	22180714			D12.6	D003110		HP:0100273	Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc.
tissue_expression_up	hsa-mir-196b	Colon Neoplasms	20132431			D12.6	D003110		HP:0100273	A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control.
tissue_expression_up	hsa-mir-19a	Colon Neoplasms	20132431			D12.6	D003110		HP:0100273	A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control.
tissue_expression_up	hsa-mir-19a	Colon Neoplasms	22043014			D12.6	D003110		HP:0100273	The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)
tissue_expression_up	hsa-mir-19b-1	Colon Neoplasms	22382630			D12.6	D003110		HP:0100273	In response to 5-FU, miR-19b and miR-21 were over-expressed in 5-FU-resistant cells.
tissue_expression_up	hsa-mir-19b-2	Colon Neoplasms	22382630			D12.6	D003110		HP:0100273	In response to 5-FU, miR-19b and miR-21 were over-expressed in 5-FU-resistant cells.
tissue_expression_up	hsa-mir-20a	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-20a	Colon Neoplasms	20132431			D12.6	D003110		HP:0100273	A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control.
tissue_expression_up	hsa-mir-21	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-21	Colon Neoplasms	22043014			D12.6	D003110		HP:0100273	The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)
tissue_expression_up	hsa-mir-215	Colon Neoplasms	22180714			D12.6	D003110		HP:0100273	Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc.
tissue_expression_up	hsa-mir-221	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-221	Colon Neoplasms	25932237			D12.6	D003110		HP:0100273	high expression of miR-211 (HR=2.394, 95% CI: 1.210-4.910, P=0.006)  were identified as risk factors for colon cancer prognosis
tissue_expression_up	hsa-mir-223	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-223	Colon Neoplasms	22043014			D12.6	D003110		HP:0100273	The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)
tissue_expression_up	hsa-mir-224	Colon Neoplasms	20132431			D12.6	D003110		HP:0100273	A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control.
tissue_expression_up	hsa-mir-24-1	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-24-2	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-29a	Colon Neoplasms	22426940			D12.6	D003110		HP:0100273	High expression of miR-29a was associated with a longer disease-free survival (DFS) for patients with stage 2 colon cancer, on both univariate and multivariate analyses.
tissue_expression_up	hsa-mir-29b	Colon Neoplasms	22180714			D12.6	D003110		HP:0100273	Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc.
tissue_expression_up	hsa-mir-29b-1	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-301b	Colon Neoplasms	20132431			D12.6	D003110		HP:0100273	A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control.
tissue_expression_up	hsa-mir-30c-1	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-30c-2	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-31	Colon Neoplasms	22043014			D12.6	D003110		HP:0100273	The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)
tissue_expression_up	hsa-mir-32	Colon Neoplasms	16461460			D12.6	D003110		HP:0100273	overexpressed
tissue_expression_up	hsa-mir-32	Colon Neoplasms	22180714			D12.6	D003110		HP:0100273	Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc.
tissue_expression_up	hsa-mir-326	Colon Neoplasms	22043014			D12.6	D003110		HP:0100273	The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)
tissue_expression_up	hsa-mir-335	Colon Neoplasms	20132431			D12.6	D003110		HP:0100273	A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control.
tissue_expression_up	hsa-mir-33a	Colon Neoplasms	22180714			D12.6	D003110		HP:0100273	Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc.
tissue_expression_up	hsa-mir-34a	Colon Neoplasms	17875987			D12.6	D003110		HP:0100273	highly upregulated
tissue_expression_up	hsa-mir-34a	Colon Neoplasms	22898888			D12.6	D003110		HP:0100273	in colonic fibroblasts p38 was only moderately activated, p53 as well as p16 expressions were upregulated in the presence of increased expression of miR-34a, miR-128a and miR-449a.
tissue_expression_up	hsa-mir-374a	Colon Neoplasms	20132431			D12.6	D003110		HP:0100273	A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control.
tissue_expression_up	hsa-mir-424	Colon Neoplasms	20132431			D12.6	D003110		HP:0100273	A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control.
tissue_expression_up	hsa-mir-449a	Colon Neoplasms	22898888			D12.6	D003110		HP:0100273	in colonic fibroblasts p38 was only moderately activated, p53 as well as p16 expressions were upregulated in the presence of increased expression of miR-34a, miR-128a and miR-449a.
tissue_expression_up	hsa-mir-629	Colon Neoplasms	19946373			D12.6	D003110		HP:0100273	upregulated
tissue_expression_up	hsa-mir-133a-2	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-133b:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa,
tissue_expression_up	hsa-mir-135a-1	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-135a:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa,
tissue_expression_up	hsa-mir-135a-2	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-135a:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa,
tissue_expression_up	hsa-mir-17	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-17:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa,
tissue_expression_up	hsa-mir-183	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-183:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa,
tissue_expression_up	hsa-mir-203	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-203:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa,
tissue_expression_up	hsa-mir-20a	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-20:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa,
tissue_expression_up	hsa-mir-223	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-223:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa,
tissue_expression_up	hsa-mir-224	Colorectal Adenocarcinoma	25420464	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-224 is significantly upregulated in malignant colorectal tumors compared to adjacent non-cancer mucosae, and its enhanced expression constitutes an independent predictor of short-term relapse and poor overall survival in colorectal adenocarcinoma patients.
tissue_expression_up	hsa-mir-25	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-25:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa,
tissue_expression_up	hsa-mir-31	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-31:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa,
tissue_expression_up	hsa-mir-92a	Colorectal Adenocarcinoma	25663865	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		A statistically significant difference was observed between the expression levels of miR-92a in CA and the paralesional normal controls.
tissue_expression_up	hsa-mir-92a-1	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-92:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa,
tissue_expression_up	hsa-mir-92a-2	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-92:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa,
tissue_expression_up	hsa-mir-93	Colorectal Adenocarcinoma	20413677	disease of cellular proliferation	DOID:0050861	C19	C000599423	114500		miR-93:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa,
tissue_expression_up	hsa-mir-106a	Colorectal Carcinoma	24670448	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		plasma miR-106a is up-regulated in CRC patients, suggesting its potential value for the diagnosis of CRC.
tissue_expression_up	hsa-mir-10b	Colorectal Carcinoma	22740910	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas.
tissue_expression_up	hsa-mir-125b	Colorectal Carcinoma	28881590	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Upregulation of microRNA-125b by G-CSF promotes metastasis in colorectal cancer
tissue_expression_up	hsa-mir-125b	Colorectal Carcinoma	22740910	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas.
tissue_expression_up	hsa-mir-126	Colorectal Carcinoma	22740910	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas.
tissue_expression_up	hsa-mir-1287	Colorectal Carcinoma	27251300	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiR-1287 was significantly upregulated in the group of CRC samples compared with matched noncancerous tissue samples.
tissue_expression_up	hsa-mir-129	Colorectal Carcinoma	25218158	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Piceatannol promotes apoptosis via up-regulation of microRNA-129 expression in colorectal cancer cell lines.
tissue_expression_up	hsa-mir-133a	Colorectal Carcinoma	22740910	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas.
tissue_expression_up	hsa-mir-133b	Colorectal Carcinoma	22740910	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas.
tissue_expression_up	hsa-mir-143	Colorectal Carcinoma	22740910	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas.
tissue_expression_up	hsa-mir-145	Colorectal Carcinoma	25019299	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Up-regulation of microRNA-145 associates with lymph node metastasis in colorectal cancer.
tissue_expression_up	hsa-mir-145	Colorectal Carcinoma	22740910	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas.
tissue_expression_up	hsa-mir-146a	Colorectal Carcinoma	22740910	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas.
tissue_expression_up	hsa-mir-181a	Colorectal Carcinoma	27264420	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		IL-1尾 induced the expression of miR-181a.
tissue_expression_up	hsa-mir-183	Colorectal Carcinoma	24150523	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The increased expression of miR-183 is closely related to advanced clinical stage, lymph node and distant metastases, and poor prognosis of CRC,indicating that miR-183 may serve as a predictive biomarker for the prognosis or the aggressiveness of CRC.
tissue_expression_up	hsa-mir-199a	Colorectal Carcinoma	24711074	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiR-199a-5p loss up-regulated DDR1 aggravated colorectal cancer by activating epithelial-to-mesenchymal transition related signaling.
tissue_expression_up	hsa-mir-199a	Colorectal Carcinoma	28639895	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Upregulation of miR-199a/b contributes to cisplatin resistance via Wnt/β-catenin-ABCG2 signaling pathway in ALDHA1+ colorectal cancer stem cells.
tissue_expression_up	hsa-mir-199a	Colorectal Carcinoma	22740910	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas.
tissue_expression_up	hsa-mir-199b	Colorectal Carcinoma	28639895	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Upregulation of miR-199a/b contributes to cisplatin resistance via Wnt/β-catenin-ABCG2 signaling pathway in ALDHA1+ colorectal cancer stem cells.
tissue_expression_up	hsa-mir-199b	Colorectal Carcinoma	22740910	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas.
tissue_expression_up	hsa-mir-200a	Colorectal Carcinoma	26790446	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression of MMP-2 and -9 was elevated, on the other hand, in cell lines derived from primary tumor cancer cells as well as the expression of miR-21, miR-29a, and miR-200a.
tissue_expression_up	hsa-mir-20a	Colorectal Carcinoma	21551242	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiR-20a and miR-31 were found to be significantly upregulated in more than one study, and miR-143 and miR-145 were found to be significantly downregulated in CRC tissue in six or more studies.
tissue_expression_up	hsa-mir-21	Colorectal Carcinoma	24265822	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The present findings suggest that high expression of miR-21 might predict poor prognosis in patients with colorectal cancer.
tissue_expression_up	hsa-mir-21	Colorectal Carcinoma	26790446	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression of MMP-2 and -9 was elevated, on the other hand, in cell lines derived from primary tumor cancer cells as well as the expression of miR-21, miR-29a, and miR-200a.
tissue_expression_up	hsa-mir-211	Colorectal Carcinoma	26152286	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MicroRNA 211 expression is upregulated and associated with poor prognosis in colorectal cancer: a case-control study.
tissue_expression_up	hsa-mir-22	Colorectal Carcinoma	22740910	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas.
tissue_expression_up	hsa-mir-25	Colorectal Carcinoma	24293092	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression of miR-25 is increased in colorectal cancer and is associated with patient prognosis.
tissue_expression_up	hsa-mir-28	Colorectal Carcinoma	22740910	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas.
tissue_expression_up	hsa-mir-29a	Colorectal Carcinoma	26790446	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression of MMP-2 and -9 was elevated, on the other hand, in cell lines derived from primary tumor cancer cells as well as the expression of miR-21, miR-29a, and miR-200a.
tissue_expression_up	hsa-mir-29b	Colorectal Carcinoma	27346400	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression level of miR-29b is reduced in colorectal cancer tissues compared with that in the adjacent colorectal tissues.
tissue_expression_up	hsa-mir-31	Colorectal Carcinoma	21551242	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MiR-20a and miR-31 were found to be significantly upregulated in more than one study, and miR-143 and miR-145 were found to be significantly downregulated in CRC tissue in six or more studies.
tissue_expression_up	hsa-mir-34a	Colorectal Carcinoma	21566225	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The gene encoding the miR-34a microRNA is a transcriptional target of the p53 tumor suppressor protein and subject to epigenetic inactivation in colorectal cancer and numerous other tumor types
tissue_expression_up	hsa-mir-576	Colorectal Carcinoma	22740910	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas.
tissue_expression_up	hsa-let-7a-1	Colorectal Carcinoma	21826996	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		upregulated in colon cancer compared to normal colonic mucosa
tissue_expression_up	hsa-let-7a-1	Colorectal Carcinoma	22120473	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases.
tissue_expression_up	hsa-let-7a-2	Colorectal Carcinoma	21826996	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		upregulated in colon cancer compared to normal colonic mucosa
tissue_expression_up	hsa-let-7a-2	Colorectal Carcinoma	22120473	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases.
tissue_expression_up	hsa-let-7a-3	Colorectal Carcinoma	21826996	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		upregulated in colon cancer compared to normal colonic mucosa
tissue_expression_up	hsa-let-7a-3	Colorectal Carcinoma	22120473	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases.
tissue_expression_up	hsa-mir-106a	Colorectal Carcinoma	21826996	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		upregulated in colon cancer compared to normal colonic mucosa
tissue_expression_up	hsa-mir-1179	Colorectal Carcinoma	21174058	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-150*, miR-125b-2*, miR-1179 and miR-139-3p were up-regulated in colorectal cancers with liver metastasis
tissue_expression_up	hsa-mir-125b-2	Colorectal Carcinoma	21174058	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-150*, miR-125b-2*, miR-1179 and miR-139-3p were up-regulated in colorectal cancers with liver metastasis
tissue_expression_up	hsa-mir-126	Colorectal Carcinoma	22397399	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The median miRNA-126 expression level was significantly higher in patients responding to XELOX (capecitabine and oxaliplatin).
tissue_expression_up	hsa-mir-135a-1	Colorectal Carcinoma	22120473	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases.
tissue_expression_up	hsa-mir-135a-2	Colorectal Carcinoma	22120473	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases.
tissue_expression_up	hsa-mir-139	Colorectal Carcinoma	21174058	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-150*, miR-125b-2*, miR-1179 and miR-139-3p were up-regulated in colorectal cancers with liver metastasis
tissue_expression_up	hsa-mir-141	Colorectal Carcinoma	25989926	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A set of three specific fecal miRNAs is overexpressed before surgery, and return within the normal range after cancer removal could be considered as an appealing opportunity for a new reliable tool for CRC secondary prevention. However, their role needs to be explored in large prospective trials and compared with the existing screening tools.
tissue_expression_up	hsa-mir-144	Colorectal Carcinoma	21863218	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Differential expression of miR-144* as a novel fecal-based diagnostic marker for colorectal cancer.
tissue_expression_up	hsa-mir-150	Colorectal Carcinoma	21174058	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-150*, miR-125b-2*, miR-1179 and miR-139-3p were up-regulated in colorectal cancers with liver metastasis
tissue_expression_up	hsa-mir-155	Colorectal Carcinoma	26261588	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-155-5p expression is up-regulated in most CRC and promotes proliferation, invasion and metastasis of CRC cells. It may play an essential role in tumorigenesis and tumor progression of CRC.
tissue_expression_up	hsa-mir-155	Colorectal Carcinoma	21412018	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		High miR-155 expression was significantly correlated with lymph node metastases. The overall (OS) and disease-free survival (DFS) rates of patients with high miR-155 expression were also significantly worse than those in patients with low miR-155 expression.
tissue_expression_up	hsa-mir-16	Colorectal Carcinoma	25989926	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A set of three specific fecal miRNAs is overexpressed before surgery, and return within the normal range after cancer removal could be considered as an appealing opportunity for a new reliable tool for CRC secondary prevention. However, their role needs to be explored in large prospective trials and compared with the existing screening tools.
tissue_expression_up	hsa-mir-17	Colorectal Carcinoma	19201770	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-17-3p: up-regulated both in plasma and tissue samples
tissue_expression_up	hsa-mir-17	Colorectal Carcinoma	19287964	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-17-5p: up-regulated
tissue_expression_up	hsa-mir-17	Colorectal Carcinoma	21826996	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		upregulated in colon cancer compared to normal colonic mucosa
tissue_expression_up	hsa-mir-181a-2	Colorectal Carcinoma	22641662	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		KRAS up-regulates the expression of miR-181a, miR-200c and miR-210 in a three-dimensional-specific manner in DLD-1 colorectal cancer cells.
tissue_expression_up	hsa-mir-182	Colorectal Carcinoma	25031782	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Increased expression of miRNA-182 in colorectal carcinoma: an independent and tissue-specific prognostic factor.
tissue_expression_up	hsa-mir-182	Colorectal Carcinoma	21826996	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		upregulated in colon cancer compared to normal colonic mucosa
tissue_expression_up	hsa-mir-182	Colorectal Carcinoma	23474644	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Up-regulation of miR-182 expression in colorectal cancer tissues and its prognostic value
tissue_expression_up	hsa-mir-183	Colorectal Carcinoma	19287964	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-183: up-regulated
tissue_expression_up	hsa-mir-185	Colorectal Carcinoma	21573504	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		High expression of miR-185 and low expression of miR-133b were correlated with poor survival (p=0.001 and 0.028, respectively) and metastasis (p=0.007 and 0.036, respectively) in colorectal cancer.
tissue_expression_up	hsa-mir-18a	Colorectal Carcinoma	19287964	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-18a: up-regulated
tissue_expression_up	hsa-mir-199a-1	Colorectal Carcinoma	23292866	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-199a-3p may serve as an efficient biomarker for diagnosis and novel prognostic indicator in colorectal cancer
tissue_expression_up	hsa-mir-199a-2	Colorectal Carcinoma	23292866	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-199a-3p may serve as an efficient biomarker for diagnosis and novel prognostic indicator in colorectal cancer
tissue_expression_up	hsa-mir-19b	Colorectal Carcinoma	25989926	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A set of three specific fecal miRNAs is overexpressed before surgery, and return within the normal range after cancer removal could be considered as an appealing opportunity for a new reliable tool for CRC secondary prevention. However, their role needs to be explored in large prospective trials and compared with the existing screening tools.
tissue_expression_up	hsa-mir-200c	Colorectal Carcinoma	21826996	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		upregulated in colon cancer compared to normal colonic mucosa
tissue_expression_up	hsa-mir-200c	Colorectal Carcinoma	22641662	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		KRAS up-regulates the expression of miR-181a, miR-200c and miR-210 in a three-dimensional-specific manner in DLD-1 colorectal cancer cells.
tissue_expression_up	hsa-mir-20a	Colorectal Carcinoma	25989926	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A set of three specific fecal miRNAs is overexpressed before surgery, and return within the normal range after cancer removal could be considered as an appealing opportunity for a new reliable tool for CRC secondary prevention. However, their role needs to be explored in large prospective trials and compared with the existing screening tools.
tissue_expression_up	hsa-mir-20a	Colorectal Carcinoma	19287964	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-20a: up-regulated
tissue_expression_up	hsa-mir-20a	Colorectal Carcinoma	21826996	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		upregulated in colon cancer compared to normal colonic mucosa
tissue_expression_up	hsa-mir-21	Colorectal Carcinoma	25989926	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A set of three specific fecal miRNAs is overexpressed before surgery, and return within the normal range after cancer removal could be considered as an appealing opportunity for a new reliable tool for CRC secondary prevention. However, their role needs to be explored in large prospective trials and compared with the existing screening tools.
tissue_expression_up	hsa-mir-21	Colorectal Carcinoma	26845148	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		In the context of previous studies demonstrating increased miRNA-21 expression in metastatic primary tumors, our findings raise the question whether miRNA-21 might be involved in the initiation but not in the perpetuation and growth of metastases.
tissue_expression_up	hsa-mir-21	Colorectal Carcinoma	21412018	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		High miR-21 expression was significantly associated with venous invasion, liver metastasis and tumor stage.The overall (OS) and disease-free survival (DFS) rates of patients with high miR-21 expression were significantly worse than those of patients with low miR-21 expression.
tissue_expression_up	hsa-mir-21	Colorectal Carcinoma	21930727	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression of miR-21 and miR-92a was significantly higher in CRC tissues compared with their adjacent normal tissues (p<0.0001). Patients with CRC had a significantly higher stool miR-21 level (p<0.01) and miR-92a level (p<0.0001) compared with normal controls. Stool miR-92a, but not miR-21, was significantly higher in patients with polyps than in controls (p<0.0001). At a cut-off value of 435 copies/ng of stool RNA, miR-92a had a sensitivity of 71.6% and 56.1% for CRC and polyp, respectively, and a specificity of 73.3%. In addition, the stool miR-92a level demonstrated a higher sensitivity for distal CRC than proximal CRC (p<0.05), and a higher sensitivity for advanced adenoma than minor polyps (p<0.05). Removal of tumour resulted in reduced stool miR-21 and miR-92a levels (p<0.01), and the removal of advanced adenoma resulted in a reduction of the stool miR-92a level (p<0.05).
tissue_expression_up	hsa-mir-21	Colorectal Carcinoma	22120473	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases.
tissue_expression_up	hsa-mir-21	Colorectal Carcinoma	22289545	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		There was a significantly higher level of miR-21 in CRC tumour tissue than in NAT and high expression of miR-21 was significantly correlated with advanced clinical stage and poor cell differentiation.
tissue_expression_up	hsa-mir-21	Colorectal Carcinoma	22382630	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		In response to 5-FU, miR-19b and miR-21 were over-expressed in 5-FU-resistant cells.
tissue_expression_up	hsa-mir-21	Colorectal Carcinoma	22476768	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Kaplan-Meier analysis proved that the miR-21 expression levels are correlated to shorter overall survival of CRC patients.
tissue_expression_up	hsa-mir-21	Colorectal Carcinoma	22638884	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control (P < 0.001), and its sensitivity and specificity were significantly higher than the currently used tumor markers.
tissue_expression_up	hsa-mir-210	Colorectal Carcinoma	22641662	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		KRAS up-regulates the expression of miR-181a, miR-200c and miR-210 in a three-dimensional-specific manner in DLD-1 colorectal cancer cells.
tissue_expression_up	hsa-mir-215	Colorectal Carcinoma	21752725	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-215 has a unique potential as a prognostic biomarker in stage II and III colon cancer.
tissue_expression_up	hsa-mir-31	Colorectal Carcinoma	19287964	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-31: up-regulated
tissue_expression_up	hsa-mir-335	Colorectal Carcinoma	22120473	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases.
tissue_expression_up	hsa-mir-34a	Colorectal Carcinoma	22562822	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		microRNA-34a, microRNA-155 and microRNA-200c overexpression in human colorectal cancer.
tissue_expression_up	hsa-mir-625	Colorectal Carcinoma	23506979	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer
tissue_expression_up	hsa-mir-9-1	Colorectal Carcinoma	21562850	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility.
tissue_expression_up	hsa-mir-9-2	Colorectal Carcinoma	21562850	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility.
tissue_expression_up	hsa-mir-92a	Colorectal Carcinoma	25989926	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		A set of three specific fecal miRNAs is overexpressed before surgery, and return within the normal range after cancer removal could be considered as an appealing opportunity for a new reliable tool for CRC secondary prevention. However, their role needs to be explored in large prospective trials and compared with the existing screening tools.
tissue_expression_up	hsa-mir-92a-1	Colorectal Carcinoma	21826996	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		upregulated in colon cancer compared to normal colonic mucosa
tissue_expression_up	hsa-mir-92a-1	Colorectal Carcinoma	21930727	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression of miR-21 and miR-92a was significantly higher in CRC tissues compared with their adjacent normal tissues (p<0.0001). Patients with CRC had a significantly higher stool miR-21 level (p<0.01) and miR-92a level (p<0.0001) compared with normal controls. Stool miR-92a, but not miR-21, was significantly higher in patients with polyps than in controls (p<0.0001). At a cut-off value of 435 copies/ng of stool RNA, miR-92a had a sensitivity of 71.6% and 56.1% for CRC and polyp, respectively, and a specificity of 73.3%. In addition, the stool miR-92a level demonstrated a higher sensitivity for distal CRC than proximal CRC (p<0.05), and a higher sensitivity for advanced adenoma than minor polyps (p<0.05). Removal of tumour resulted in reduced stool miR-21 and miR-92a levels (p<0.01), and the removal of advanced adenoma resulted in a reduction of the stool miR-92a level (p<0.05).
tissue_expression_up	hsa-mir-92a-1	Colorectal Carcinoma	22772712	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		Overexpression of miR-92a correlates with tumor metastasis and poor prognosis in patients with colorectal cancer.
tissue_expression_up	hsa-mir-92a-2	Colorectal Carcinoma	21826996	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		upregulated in colon cancer compared to normal colonic mucosa
tissue_expression_up	hsa-mir-92a-2	Colorectal Carcinoma	21930727	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		The expression of miR-21 and miR-92a was significantly higher in CRC tissues compared with their adjacent normal tissues (p<0.0001). Patients with CRC had a significantly higher stool miR-21 level (p<0.01) and miR-92a level (p<0.0001) compared with normal controls. Stool miR-92a, but not miR-21, was significantly higher in patients with polyps than in controls (p<0.0001). At a cut-off value of 435 copies/ng of stool RNA, miR-92a had a sensitivity of 71.6% and 56.1% for CRC and polyp, respectively, and a specificity of 73.3%. In addition, the stool miR-92a level demonstrated a higher sensitivity for distal CRC than proximal CRC (p<0.05), and a higher sensitivity for advanced adenoma than minor polyps (p<0.05). Removal of tumour resulted in reduced stool miR-21 and miR-92a levels (p<0.01), and the removal of advanced adenoma resulted in a reduction of the stool miR-92a level (p<0.05).
tissue_expression_up	hsa-mir-92b	Colorectal Carcinoma	19287964	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		miR-92: up-regulated
tissue_expression_up	hsa-mir-93	Colorectal Carcinoma	21826996	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		upregulated in colon cancer compared to normal colonic mucosa
tissue_expression_up	hsa-mir-9-3	Colorectal Carcinoma	21562850	disease of cellular proliferation	DOID:0080199	C19	D015179	114500		MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility.
tissue_expression_up	hsa-mir-155	Congenital Heart Diseases	29281614	cardiovascular system disease	DOID:1682	Q24	D006330	617912	HP:0030680	Mir-486-3p, mir-486-5p, and mir-155-5p increased in patients with cyanotic heart disease compared with those without heart disease
tissue_expression_up	hsa-mir-486	Congenital Heart Diseases	29281614	cardiovascular system disease	DOID:1682	Q24	D006330	617912	HP:0030680	Mir-486-3p, mir-486-5p, and mir-155-5p increased in patients with cyanotic heart disease compared with those without heart disease
tissue_expression_up	hsa-mir-1-1	Coronary Artery Disease	17401374	cardiovascular system disease	DOID:3393	I20-I25	D003324	608320		overexpressed
tissue_expression_up	hsa-mir-1-2	Coronary Artery Disease	17401374	cardiovascular system disease	DOID:3393	I20-I25	D003324	608320		overexpressed
tissue_expression_up	hsa-mir-21	Coronary Artery Disease	26183619	cardiovascular system disease	DOID:3393	I20-I25	D003324	608320		miR-21 expression was increased in human tissue samples from patients with ISR compared with coronary artery disease specimen
tissue_expression_up	hsa-mir-23a	Coronary Artery Disease	27085964	cardiovascular system disease	DOID:3393	I20-I25	D003324	608320		MiR-23a was enriched in not only diseased endothelial progenitor cells (EPCs) but also in the plasma of patients with coronary artery disease (CAD).
tissue_expression_up	hsa-mir-146a	Creutzfeldt-Jakob Disease	22043907	nervous system disease	DOID:11949	A81.0	D007562	123400		Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome.
tissue_expression_up	hsa-mir-146a	Crohn Disease	27468194	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	The elevated expression of miR-146a and -155 in the inflamed duodenal mucosa of CD patients suggests the role of these miRs in the pathomechanism of inflammatory bowel disease.
tissue_expression_up	hsa-mir-155	Crohn Disease	27468194	gastrointestinal system disease	DOID:8778	K50	D003424	266600	HP:0100280	The elevated expression of miR-146a and -155 in the inflamed duodenal mucosa of CD patients suggests the role of these miRs in the pathomechanism of inflammatory bowel disease.
tissue_expression_up	hsa-mir-106b	Cutaneous Melanoma	26662433	disease of cellular proliferation	DOID:8923	C43	C562393	PS155600	HP:0012056	This study showed that miR-106b may contribute to the progression of cutaneous melanoma and its up-regulation may be independently associated with poor prognosis of cutaneous melanoma. This suggests that miR-106b might serve as a promising biological marker for further risk stratification in the management of cutaneous melanoma.
tissue_expression_up	hsa-mir-155	Demyelinating Diseases	22517757	nervous system disease	DOID:3213	G37.9	D003711	118200		Both in vivo and in vitro, myelin antigen stimulation resulted in significant up-regulation of miR-301a, miR-21, and miR-155.
tissue_expression_up	hsa-mir-21	Demyelinating Diseases	22517757	nervous system disease	DOID:3213	G37.9	D003711	118200		Both in vivo and in vitro, myelin antigen stimulation resulted in significant up-regulation of miR-301a, miR-21, and miR-155.
tissue_expression_up	hsa-mir-146a	Diabetes Mellitus	25490205	disease of metabolism	DOID:9351	E10-E14	D003920	222100	HP:0000819	abnormal miR-146a upregulation may be an important mechanism of delayed wound healing in the diabetic cornea.
tissue_expression_up	hsa-mir-375	Diabetes Mellitus	25875172	disease of metabolism	DOID:9351	E10-E14	D003920	222100	HP:0000819	These findings support an important role of miR-375 in regulation of human β-cell phenotype, and suggest that miR-375 upregulation may facilitate the generation of functional insulin-producing cells following ex-vivo expansion of human islet cells.
tissue_expression_up	hsa-mir-181a	Diabetes Mellitus, Type 1	26892629	disease of metabolism	DOID:9744	E10	D003922	222100	HP:0100651	miRNA-181a expression was significantly higher in diabetic children and  adolescents
tissue_expression_up	hsa-mir-107	Diabetes Mellitus, Type 2	19689793	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	over-expressed in insulin target tissues
tissue_expression_up	hsa-mir-143	Diabetes Mellitus, Type 2	21441927	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism.
tissue_expression_up	hsa-mir-143	Diabetes Mellitus, Type 2	24333576	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	Adipocyte-derived factors impair insulin signaling in differentiated human vascular smooth muscle cells via the upregulation of miR-143.
tissue_expression_up	hsa-mir-192	Diabetes Mellitus, Type 2	23372846	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	Several highly-expressed islet miRNAs, such as miR-375, have established roles in the regulation of islet function, but others (e.g. miR-27b-3p, miR-192-5p) have not previously been described in the context of islet biology.
tissue_expression_up	hsa-mir-27b	Diabetes Mellitus, Type 2	23372846	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	Several highly-expressed islet miRNAs, such as miR-375, have established roles in the regulation of islet function, but others (e.g. miR-27b-3p, miR-192-5p) have not previously been described in the context of islet biology.
tissue_expression_up	hsa-mir-375	Diabetes Mellitus, Type 2	23372846	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	Several highly-expressed islet miRNAs, such as miR-375, have established roles in the regulation of islet function, but others (e.g. miR-27b-3p, miR-192-5p) have not previously been described in the context of islet biology.
tissue_expression_up	hsa-mir-483	Diabetes Mellitus, Type 2	22223106	disease of metabolism	DOID:9352	E11	D003924	125853	HP:0005978	Increased miR-483-3p expression in vivo, programmed by early-life nutrition, limits storage of lipids in adipose tissue, causing lipotoxicity and insulin resistance and thus increasing susceptibility to metabolic disease.
tissue_expression_up	hsa-mir-30d	Diabetic Cardiomyopathies	25341033				D058065			Our study revealed that mir-30d expression was substantially increased in streptozotocin (STZ)-induced diabetic rats and in high-glucose-treated cardiomyocytes as well.
tissue_expression_up	hsa-mir-146a	Diabetic Nephropathy	25182190			E10-11.21	D003928			Taken together, these findings indicate that the increased expression of miR-155 and miR-146a in the DN patients and in the experimental DN animal models was found to contribute to inflammation-mediated glomerular endothelial injury.
tissue_expression_up	hsa-mir-155	Diabetic Nephropathy	25182190			E10-11.21	D003928			Taken together, these findings indicate that the increased expression of miR-155 and miR-146a in the DN patients and in the experimental DN animal models was found to contribute to inflammation-mediated glomerular endothelial injury.
tissue_expression_up	hsa-mir-192	Diabetic Nephropathy	22211842			E10-11.21	D003928			TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated.
tissue_expression_up	hsa-mir-21	Diabetic Nephropathy	22211842			E10-11.21	D003928			TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated.
tissue_expression_up	hsa-mir-155	Down Syndrome	22182977	genetic disease	DOID:14250	Q90	D004314	190685		a screening of micro-RNA (miRNA) from Down's syndrome brain and peripheral tissues indicated an upregulation of a chromosome 21-encoded miRNA-155 and a decrease in the abundance of the miRNA-155 mRNA target complement factor H (CFH), an important repressor of the innate immune response.
tissue_expression_up	hsa-mir-155	Early-Stage Breast Carcinoma	24938880			D05.10	D001943	114480		OncomiRs are significantly more abundant in the sera of EBC patients compared to controls at diagnosis. Differences in oncomiR levels reflecting EBC risk were also observed. Testing the oncomiRs may be useful for diagnostic purpose and possibly also for relapse detection in follow-up studies of EBC.
tissue_expression_up	hsa-mir-181b	Early-Stage Breast Carcinoma	24938880			D05.10	D001943	114480		OncomiRs are significantly more abundant in the sera of EBC patients compared to controls at diagnosis. Differences in oncomiR levels reflecting EBC risk were also observed. Testing the oncomiRs may be useful for diagnostic purpose and possibly also for relapse detection in follow-up studies of EBC.
tissue_expression_up	hsa-mir-19a	Early-Stage Breast Carcinoma	24938880			D05.10	D001943	114480		OncomiRs are significantly more abundant in the sera of EBC patients compared to controls at diagnosis. Differences in oncomiR levels reflecting EBC risk were also observed. Testing the oncomiRs may be useful for diagnostic purpose and possibly also for relapse detection in follow-up studies of EBC.
tissue_expression_up	hsa-mir-24	Early-Stage Breast Carcinoma	24938880			D05.10	D001943	114480		OncomiRs are significantly more abundant in the sera of EBC patients compared to controls at diagnosis. Differences in oncomiR levels reflecting EBC risk were also observed. Testing the oncomiRs may be useful for diagnostic purpose and possibly also for relapse detection in follow-up studies of EBC.
tissue_expression_up	hsa-mir-195	Eclampsia	19642860	cardiovascular system disease	DOID:13593	O15.9	D004461	189800		increased in placenta
tissue_expression_up	hsa-mir-21	Eclampsia	19642860	cardiovascular system disease	DOID:13593	O15.9	D004461	189800		increased in placenta
tissue_expression_up	hsa-mir-222	Eclampsia	19642860	cardiovascular system disease	DOID:13593	O15.9	D004461	189800		increased in placenta
tissue_expression_up	hsa-mir-26b	Eclampsia	19642860	cardiovascular system disease	DOID:13593	O15.9	D004461	189800		increased in placenta
tissue_expression_up	hsa-mir-335	Eclampsia	19642860	cardiovascular system disease	DOID:13593	O15.9	D004461	189800		increased in placenta
tissue_expression_up	hsa-mir-1288	Ectopic Pregnancy	25013942	reproductive system disease	DOID:0060329	O00.9	D011271		HP:0031456	Microarray studies showed that four miRNAs were differentially  downregulated (hsa-mir-196b, hsa-mir-30a, hsa-mir-873, and hsa-mir-337-3p) and three upregulated (hsa-mir-1288, hsa-mir-451, and hsa-mir-223) in EP compared to  control tissue samples.
tissue_expression_up	hsa-mir-223	Ectopic Pregnancy	25013942	reproductive system disease	DOID:0060329	O00.9	D011271		HP:0031456	Microarray studies showed that four miRNAs were differentially  downregulated (hsa-mir-196b, hsa-mir-30a, hsa-mir-873, and hsa-mir-337-3p) and three upregulated (hsa-mir-1288, hsa-mir-451, and hsa-mir-223) in EP compared to  control tissue samples.
tissue_expression_up	hsa-mir-451	Ectopic Pregnancy	25013942	reproductive system disease	DOID:0060329	O00.9	D011271		HP:0031456	Microarray studies showed that four miRNAs were differentially  downregulated (hsa-mir-196b, hsa-mir-30a, hsa-mir-873, and hsa-mir-337-3p) and three upregulated (hsa-mir-1288, hsa-mir-451, and hsa-mir-223) in EP compared to  control tissue samples.
tissue_expression_up	hsa-let-7b	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_up	hsa-mir-146b	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_up	hsa-mir-183	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_up	hsa-mir-21	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_up	hsa-mir-221	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_up	hsa-mir-222	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_up	hsa-mir-25	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_up	hsa-mir-31	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_up	hsa-mir-584	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_up	hsa-mir-595	Endocrine Gland Neoplasms	28322989			D35.9	D004701			Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)
tissue_expression_up	hsa-mir-141	Endometrial Neoplasms	21897839	reproductive system disease	DOID:1380	C54.1	D016889	608089		The entire miR-200 family (miR-200a/b/c, miR-141, and miR-429) was up-regulated in cases of EEC (endometrioid endometrial adenocarcinoma).
tissue_expression_up	hsa-mir-142	Endometrial Neoplasms	22543862	reproductive system disease	DOID:1380	C54.1	D016889	608089		miR-142-5p: Increased expression after Progesterone Treatment.
tissue_expression_up	hsa-mir-146b	Endometrial Neoplasms	22543862	reproductive system disease	DOID:1380	C54.1	D016889	608089		miR-146b-5p: Increased expression after Progesterone Treatment.
tissue_expression_up	hsa-mir-155	Endometrial Neoplasms	22525818	reproductive system disease	DOID:1380	C54.1	D016889	608089		miR-155 was over-expressed and AGTR1 was underexpressed in endometrial carcinoma tissues.
tissue_expression_up	hsa-mir-200a	Endometrial Neoplasms	21897839	reproductive system disease	DOID:1380	C54.1	D016889	608089		The entire miR-200 family (miR-200a/b/c, miR-141, and miR-429) was up-regulated in cases of EEC (endometrioid endometrial adenocarcinoma).
tissue_expression_up	hsa-mir-200b	Endometrial Neoplasms	21897839	reproductive system disease	DOID:1380	C54.1	D016889	608089		The entire miR-200 family (miR-200a/b/c, miR-141, and miR-429) was up-regulated in cases of EEC (endometrioid endometrial adenocarcinoma).
tissue_expression_up	hsa-mir-200b	Endometrial Neoplasms	22904162	reproductive system disease	DOID:1380	C54.1	D016889	608089		miR-200b and -210 were significantly up-regulated in the cancerous endometrium.
tissue_expression_up	hsa-mir-200c	Endometrial Neoplasms	21897839	reproductive system disease	DOID:1380	C54.1	D016889	608089		The entire miR-200 family (miR-200a/b/c, miR-141, and miR-429) was up-regulated in cases of EEC (endometrioid endometrial adenocarcinoma).
tissue_expression_up	hsa-mir-200c	Endometrial Neoplasms	22514717	reproductive system disease	DOID:1380	C54.1	D016889	608089		The expression levels of miR-200c (P<0.0001) and miR-205 (P<0.0001) were significantly increased in endometrial tumors compared to normal tissues. Kaplan-Meier survival analysis revealed that high levels of miR-205 expression were associated with poor patient overall survival.
tissue_expression_up	hsa-mir-205	Endometrial Neoplasms	22514717	reproductive system disease	DOID:1380	C54.1	D016889	608089		The expression levels of miR-200c (P<0.0001) and miR-205 (P<0.0001) were significantly increased in endometrial tumors compared to normal tissues. Kaplan-Meier survival analysis revealed that high levels of miR-205 expression were associated with poor patient overall survival.
tissue_expression_up	hsa-mir-21	Endometrial Neoplasms	21330826	reproductive system disease	DOID:1380	C54.1	D016889	608089		Highly increased maspin expression corresponds with up-regulation of miR-21 in endometrial cancer
tissue_expression_up	hsa-mir-21	Endometrial Neoplasms	22543862	reproductive system disease	DOID:1380	C54.1	D016889	608089		Increased expression after Progesterone Treatment.
tissue_expression_up	hsa-mir-210	Endometrial Neoplasms	22904162	reproductive system disease	DOID:1380	C54.1	D016889	608089		miR-200b and -210 were significantly up-regulated in the cancerous endometrium.
tissue_expression_up	hsa-mir-429	Endometrial Neoplasms	21897839	reproductive system disease	DOID:1380	C54.1	D016889	608089		The entire miR-200 family (miR-200a/b/c, miR-141, and miR-429) was up-regulated in cases of EEC (endometrioid endometrial adenocarcinoma).
tissue_expression_up	hsa-mir-625	Endometrial Neoplasms	22543862	reproductive system disease	DOID:1380	C54.1	D016889	608089		miR-625*: Increased expression after Progesterone Treatment.
tissue_expression_up	hsa-mir-100	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-100: upregulated
tissue_expression_up	hsa-mir-100	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	up-regulated in endometriomas compared with endometrium.
tissue_expression_up	hsa-mir-10b	Endometriosis	25896413	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-10b directly targets ZEB1 and PIK3CA to curb adenomyotic epithelial cell invasiveness via upregulation of E-Cadherin and inhibition of Akt phosphorylation.
tissue_expression_up	hsa-mir-1-1	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-1: upregulated
tissue_expression_up	hsa-mir-1-2	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-1: upregulated
tissue_expression_up	hsa-mir-125a	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-125a: upregulated
tissue_expression_up	hsa-mir-125b-1	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-125b: upregulated
tissue_expression_up	hsa-mir-125b-2	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-125b: upregulated
tissue_expression_up	hsa-mir-126	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-126: upregulated
tissue_expression_up	hsa-mir-141	Endometriosis	25386850	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	We found five miRNAs specific to epithelial cells--miR-34c, miR-449a, miR-200a, miR-200b and miR-141 showing significantly higher expression in peritoneal endometriotic lesions compared to healthy peritoneal tissues.
tissue_expression_up	hsa-mir-143	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-143: upregulated
tissue_expression_up	hsa-mir-143	Endometriosis	25408705	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-143 was up-regulated in EC (p=0.000) compared to EN.
tissue_expression_up	hsa-mir-145	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-145: upregulated
tissue_expression_up	hsa-mir-145	Endometriosis	24495683	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	Up-regulation of mir-29c, mir-200a, mir-145 in the endometrial tissue might play a role in endometriosis associated infertility.
tissue_expression_up	hsa-mir-145	Endometriosis	25408705	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	The miR-145 was up-regulated in both EU (p=0.004) and EC (p=0.000) in compared to EN group.
tissue_expression_up	hsa-mir-150	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-150: upregulated
tissue_expression_up	hsa-mir-193a	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-193a-3p and miR-193a-5p up-regulated in endometriomas compared with endometrium.
tissue_expression_up	hsa-mir-194-1	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-194: upregulated
tissue_expression_up	hsa-mir-194-2	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-194: upregulated
tissue_expression_up	hsa-mir-200a	Endometriosis	24495683	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	Up-regulation of mir-29c, mir-200a, mir-145 in the endometrial tissue might play a role in endometriosis associated infertility.
tissue_expression_up	hsa-mir-200b	Endometriosis	25386850	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	We found five miRNAs specific to epithelial cells--miR-34c, miR-449a, miR-200a, miR-200b and miR-141 showing significantly higher expression in peritoneal endometriotic lesions compared to healthy peritoneal tissues.
tissue_expression_up	hsa-mir-202	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	up-regulated in endometriomas compared with endometrium.
tissue_expression_up	hsa-mir-223	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-223: upregulated
tissue_expression_up	hsa-mir-29c	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-29c: upregulated
tissue_expression_up	hsa-mir-29c	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	up-regulated in endometriomas compared with endometrium.
tissue_expression_up	hsa-mir-29c	Endometriosis	24495683	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	Up-regulation of mir-29c, mir-200a, mir-145 in the endometrial tissue might play a role in endometriosis associated infertility.
tissue_expression_up	hsa-mir-365a	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-365: upregulated
tissue_expression_up	hsa-mir-365b	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-365: upregulated
tissue_expression_up	hsa-mir-485	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-485-3p up-regulated in endometriomas compared with endometrium.
tissue_expression_up	hsa-mir-509-3	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-509-3-5p up-regulated in endometriomas compared with endometrium.
tissue_expression_up	hsa-mir-574	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-574-3p up-regulated in endometriomas compared with endometrium.
tissue_expression_up	hsa-mir-708	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	up-regulated in endometriomas compared with endometrium.
tissue_expression_up	hsa-mir-720	Endometriosis	21436257	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	up-regulated in endometriomas compared with endometrium.
tissue_expression_up	hsa-mir-99a	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-99a: upregulated
tissue_expression_up	hsa-mir-99b	Endometriosis	19074548	reproductive system disease	DOID:289	N80.0	D004715	131200	HP:0030127	miR-99b: upregulated
tissue_expression_up	hsa-mir-143	Endotoxemia	19284987				D019446			Data analysis revealed that five miRNAs consistently responded to LPS-infusion, four of which were down-regulated (miR-146b, miR-150, miR-342, and let-7g) and one was up-regulated (miR-143). The miR-150 and mir-342 response was confirmed by real-time PCR.
tissue_expression_up	hsa-mir-142	Eosinophilic Esophagitis	22815788	gastrointestinal system disease	DOID:13922	K20.0	D057765	610247		Compared to the post-glucocorticoid treated esophageal mucosa,MiR-214, miR-146b-5b, 146a, 145, 142-3p and 21 were upregulated.
tissue_expression_up	hsa-mir-145	Eosinophilic Esophagitis	22815788	gastrointestinal system disease	DOID:13922	K20.0	D057765	610247		Compared to the post-glucocorticoid treated esophageal mucosa,MiR-214, miR-146b-5b, 146a, 145, 142-3p and 21 were upregulated.
tissue_expression_up	hsa-mir-146a	Eosinophilic Esophagitis	22815788	gastrointestinal system disease	DOID:13922	K20.0	D057765	610247		Compared to the post-glucocorticoid treated esophageal mucosa,MiR-214, miR-146b-5b, 146a, 145, 142-3p and 21 were upregulated.
tissue_expression_up	hsa-mir-146b	Eosinophilic Esophagitis	22815788	gastrointestinal system disease	DOID:13922	K20.0	D057765	610247		Compared to the post-glucocorticoid treated esophageal mucosa,MiR-214, miR-146b-5b, 146a, 145, 142-3p and 21 were upregulated.
tissue_expression_up	hsa-mir-21	Eosinophilic Esophagitis	22815788	gastrointestinal system disease	DOID:13922	K20.0	D057765	610247		Compared to the post-glucocorticoid treated esophageal mucosa,MiR-214, miR-146b-5b, 146a, 145, 142-3p and 21 were upregulated.
tissue_expression_up	hsa-mir-10b	Ependymoma	29658967	disease of cellular proliferation	DOID:5074	C71.0	D004806		HP:0002888	low expression of miR-10a and over-expression of miR-10b and miR-29a in ependymoma
tissue_expression_up	hsa-mir-135a-1	Ependymoma	22053178	disease of cellular proliferation	DOID:5074	C71.0	D004806		HP:0002888	overexpression
tissue_expression_up	hsa-mir-135a-2	Ependymoma	22053178	disease of cellular proliferation	DOID:5074	C71.0	D004806		HP:0002888	overexpression
tissue_expression_up	hsa-mir-15a	Ependymoma	26813564	disease of cellular proliferation	DOID:5074	C71.0	D004806		HP:0002888	miR-15a and miR-24-1 were found upregulated in EP relapsed and EP deceased cases
tissue_expression_up	hsa-mir-17	Ependymoma	22053178	disease of cellular proliferation	DOID:5074	C71.0	D004806		HP:0002888	miR-17-5p: overexpression
tissue_expression_up	hsa-mir-24	Ependymoma	26813564	disease of cellular proliferation	DOID:5074	C71.0	D004806		HP:0002888	miR-15a and miR-24-1 were found upregulated in EP relapsed and EP deceased cases
tissue_expression_up	hsa-mir-29a	Ependymoma	29658967	disease of cellular proliferation	DOID:5074	C71.0	D004806		HP:0002888	low expression of miR-10a and over-expression of miR-10b and miR-29a in ependymoma
tissue_expression_up	hsa-mir-190	Epstein-Barr Virus Infection	25086243			B27.90	D020031	300853		mir-190 is upregulated in Epstein-Barr Virus type I latency and modulates cellular mRNAs involved in cell survival and viral reactivation.
tissue_expression_up	hsa-mir-101-1	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	upregulated
tissue_expression_up	hsa-mir-101-2	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	upregulated
tissue_expression_up	hsa-mir-106	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_up	hsa-mir-106b	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_up	hsa-mir-10b	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_up	hsa-mir-126	Esophageal Neoplasms	21269950			C15.9	D004938	133239	HP:0100751	hsa-mir-126 is upregulated and hsa-miR-518b is downregulated in esophageal squamous carcinoma
tissue_expression_up	hsa-mir-130a	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	upregulated
tissue_expression_up	hsa-mir-130b	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	upregulated
tissue_expression_up	hsa-mir-135b	Esophageal Neoplasms	22939244			C15.9	D004938	133239	HP:0100751	Patients with high levels of miR-135b or miR-145 in the posttreatment biopsy specimens had significantly shorter median disease-free survival (DFS) than did those with low levels.
tissue_expression_up	hsa-mir-143	Esophageal Neoplasms	21453382			C15.9	D004938	133239	HP:0100751	The high levels of expression of mature MIR143 and mature MIR145 were associated with recurrence of metastasis in ESCC patients.The high expression of mature MIR21 and mature MIR205 was associated with lymph node positivity in ESCC patients (P < 0.05).
tissue_expression_up	hsa-mir-143	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	upregulated
tissue_expression_up	hsa-mir-145	Esophageal Neoplasms	21453382			C15.9	D004938	133239	HP:0100751	The high levels of expression of mature MIR143 and mature MIR145 were associated with recurrence of metastasis in ESCC patients.The high expression of mature MIR21 and mature MIR205 was associated with lymph node positivity in ESCC patients (P < 0.05).
tissue_expression_up	hsa-mir-145	Esophageal Neoplasms	23477513			C15.9	D004938	133239	HP:0100751	patients with either decreased miR-135b or increased miR-145 expression in cancer tissue had improved disease-free survival
tissue_expression_up	hsa-mir-151	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_up	hsa-mir-15a	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	upregulated
tissue_expression_up	hsa-mir-192	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_up	hsa-mir-194	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_up	hsa-mir-196b	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	upregulated
tissue_expression_up	hsa-mir-200a	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	upregulated
tissue_expression_up	hsa-mir-203	Esophageal Neoplasms	18242245			C15.9	D004938	133239	HP:0100751	Both mir_203 and mir_205 were expressed 2- to 10-fold lower in squamous cell carcinoma and adenocarcinomas than in normal epithelium.
tissue_expression_up	hsa-mir-205	Esophageal Neoplasms	21453382			C15.9	D004938	133239	HP:0100751	The high levels of expression of mature MIR143 and mature MIR145 were associated with recurrence of metastasis in ESCC patients.The high expression of mature MIR21 and mature MIR205 was associated with lymph node positivity in ESCC patients (P < 0.05).
tissue_expression_up	hsa-mir-205	Esophageal Neoplasms	18242245			C15.9	D004938	133239	HP:0100751	Both mir_203 and mir_205 were expressed 2- to 10-fold lower in squamous cell carcinoma and adenocarcinomas than in normal epithelium.
tissue_expression_up	hsa-mir-21	Esophageal Neoplasms	19276261			C15.9	D004938	133239	HP:0100751	miR-21: overexpressed compared with with matched normal epitheliums, regulates the proliferation and invasion
tissue_expression_up	hsa-mir-21	Esophageal Neoplasms	21453382			C15.9	D004938	133239	HP:0100751	The high levels of expression of mature MIR143 and mature MIR145 were associated with recurrence of metastasis in ESCC patients.The high expression of mature MIR21 and mature MIR205 was associated with lymph node positivity in ESCC patients (P < 0.05).
tissue_expression_up	hsa-mir-21	Esophageal Neoplasms	22638884			C15.9	D004938	133239	HP:0100751	miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control (P < 0.001), and its sensitivity and specificity were significantly higher than the currently used tumor markers.
tissue_expression_up	hsa-mir-21	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_up	hsa-mir-210	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	upregulated
tissue_expression_up	hsa-mir-223	Esophageal Neoplasms	21453483			C15.9	D004938	133239	HP:0100751	miR-223 regulates migration and invasion by targeting Artemin in human esophageal carcinoma.
tissue_expression_up	hsa-mir-25	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_up	hsa-mir-27a	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	upregulated
tissue_expression_up	hsa-mir-28	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	miR-28-3p: upregulated
tissue_expression_up	hsa-mir-31	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	upregulated
tissue_expression_up	hsa-mir-31	Esophageal Neoplasms	26918602			C15.9	D004938	133239	HP:0100751	miR-223, miR-21, and miR-31 as the top-up-regulated species
tissue_expression_up	hsa-mir-452	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	upregulated
tissue_expression_up	hsa-mir-92a	Esophageal Neoplasms	26498375			C15.9	D004938	133239	HP:0100751	13 miRNAs were up-regulated including hsa-mir-153-2, hsa-mir-92a-1 and hsa-mir-182; while 27 miRNAs were down-regulated including hsa-mir comprising 29a, hsa-mir-100 and hsa-mir-139 and  so on.
tissue_expression_up	hsa-mir-93	Esophageal Neoplasms	23092349			C15.9	D004938	133239	HP:0100751	A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. 
tissue_expression_up	hsa-mir-99b	Esophageal Neoplasms	23761828			C15.9	D004938	133239	HP:0100751	upregulated
tissue_expression_up	hsa-mir-143	Esophagitis	23297865	gastrointestinal system disease	DOID:11963	K20	D004941		HP:0100633	Elevated miR-143, miR-145 and miR-205 expression was observed in oesophageal squamous mucosa of individuals with ulcerative oesophagitis.
tissue_expression_up	hsa-mir-145	Esophagitis	23297865	gastrointestinal system disease	DOID:11963	K20	D004941		HP:0100633	Elevated miR-143, miR-145 and miR-205 expression was observed in oesophageal squamous mucosa of individuals with ulcerative oesophagitis.
tissue_expression_up	hsa-mir-205	Esophagitis	23297865	gastrointestinal system disease	DOID:11963	K20	D004941		HP:0100633	Elevated miR-143, miR-145 and miR-205 expression was observed in oesophageal squamous mucosa of individuals with ulcerative oesophagitis.
tissue_expression_up	hsa-mir-1224	Fatty Liver [unspecific]	19572984	disease of metabolism	DOID:9452	K76.0	D005234	613282	HP:0001397	expression increased after Lieber-DeCarli or MCD;
tissue_expression_up	hsa-mir-182	Fatty Liver [unspecific]	19572984	disease of metabolism	DOID:9452	K76.0	D005234	613282	HP:0001397	expression increased after Lieber-DeCarli or MCD;
tissue_expression_up	hsa-mir-125b	Fatty Liver, Non-Alcoholic	26272872	disease of metabolism	DOID:0080208	K75.81	D065626	613282		Our findings identify a novel mechanism by which estrogen protects against hepatic steatosis in female mice via upregulating miR-125b expression.
tissue_expression_up	hsa-mir-149	Fatty Liver, Non-Alcoholic	27061435	disease of metabolism	DOID:0080208	K75.81	D065626	613282		miR-149 was increased in HepG2 cells treated with long-chain fatty acid (FFA)
tissue_expression_up	hsa-mir-200a	Fatty Liver, Non-Alcoholic	20956972	disease of metabolism	DOID:0080208	K75.81	D065626	613282		The miRNAs analysis showed the significant downregulation of three miRNAs (miR-122, miR-451 and miR-27) and the upregulation of miR-200a, miR-200b and miR-429 in HFD, SD-HF and HFD-HF rats
tissue_expression_up	hsa-mir-200b	Fatty Liver, Non-Alcoholic	20956972	disease of metabolism	DOID:0080208	K75.81	D065626	613282		The miRNAs analysis showed the significant downregulation of three miRNAs (miR-122, miR-451 and miR-27) and the upregulation of miR-200a, miR-200b and miR-429 in HFD, SD-HF and HFD-HF rats
tissue_expression_up	hsa-mir-429	Fatty Liver, Non-Alcoholic	20956972	disease of metabolism	DOID:0080208	K75.81	D065626	613282		The miRNAs analysis showed the significant downregulation of three miRNAs (miR-122, miR-451 and miR-27) and the upregulation of miR-200a, miR-200b and miR-429 in HFD, SD-HF and HFD-HF rats
tissue_expression_up	hsa-mir-21	Fibromatosis, Aggressive	28418912				D018222			The correlation between sporadic DTs and miRNA expression showed that miR-21-3p increased in mutated versus wild-type DTs, while miR-197-3p was decreased
tissue_expression_up	hsa-let-7g	Follicular Atresia	25824548				D005496			let-7g was highly  expressed during follicle atresia
tissue_expression_up	hsa-mir-101-2	Gastric Neoplasms	22450781	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Lack of microRNA-101 causes E-cadherin functional deregulation through EZH2 upregulation in intestinal gastric cancer.
tissue_expression_up	hsa-mir-106a	Gastric Neoplasms	25115709	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Similarly up-regulated microRNA-106a in matched formalin-fixed paraffin-embedded and fresh frozen samples and the dynamic changes during gastric carcinogenesis and development.
tissue_expression_up	hsa-mir-106a	Gastric Neoplasms	18996365	disease of cellular proliferation	DOID:10534	C16	D013274	137215		The level of miR-106a in cancer tissues was significantly higher than that in non-tumor tissues, with an average 1.625-fold increase. miR-106a level was significantly associated with tumor stage, size and differentiation; lymphatic and distant metastasis; and invasion (P<0.01).
tissue_expression_up	hsa-mir-106a	Gastric Neoplasms	22431000	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-106a Is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS.
tissue_expression_up	hsa-mir-106b	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-106b: overexpressed
tissue_expression_up	hsa-mir-107	Gastric Neoplasms	16461460	disease of cellular proliferation	DOID:10534	C16	D013274	137215		overexpressed
tissue_expression_up	hsa-mir-107	Gastric Neoplasms	22407237	disease of cellular proliferation	DOID:10534	C16	D013274	137215		In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients.
tissue_expression_up	hsa-mir-129	Gastric Neoplasms	24969565	disease of cellular proliferation	DOID:10534	C16	D013274	137215		lncRNA-AC130710 targeting by miR-129-5p is upregulated in gastric cancer and associates with poor prognosis.
tissue_expression_up	hsa-mir-142	Gastric Neoplasms	21343377	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A high frequency recurrence and poor survival were observed in gastric cancer cases with high level of hsa-miR-375 and low level of hsa-miR-142-5p (P < 0.001). The results indicate that the combination of hsa-miR-375 and hsa-miR-142-5p as a predictor of disease progression has the potential to predict recurrence risk for GC patients.
tissue_expression_up	hsa-mir-142	Gastric Neoplasms	22407237	disease of cellular proliferation	DOID:10534	C16	D013274	137215		In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients.
tissue_expression_up	hsa-mir-148a	Gastric Neoplasms	21703006	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-148a could reduce the invasiveness, migratory and adhesive activities of gastric tumor cells. Most importantly, elevated miR-148a level in gastric cancer tissues was strongly correlated with distant metastasis, organ and peritoneal invasion and reduced survival rate.
tissue_expression_up	hsa-mir-150	Gastric Neoplasms	19148490	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-150: patients with high expression levels have lower survival time
tissue_expression_up	hsa-mir-150	Gastric Neoplasms	22407237	disease of cellular proliferation	DOID:10534	C16	D013274	137215		In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients.
tissue_expression_up	hsa-mir-17	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-17: overexpressed
tissue_expression_up	hsa-mir-17	Gastric Neoplasms	22407237	disease of cellular proliferation	DOID:10534	C16	D013274	137215		In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients.
tissue_expression_up	hsa-mir-181b-1	Gastric Neoplasms	21876743	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Doxifluridine/Oxaliplatin treated advanced stage gastric cancer patients. The expression of miR-181b and miR-21 was significantly overexpressed in gastric tumors compared to normal gastric tissues.
tissue_expression_up	hsa-mir-181b-1	Gastric Neoplasms	22901205	disease of cellular proliferation	DOID:10534	C16	D013274	137215		The upregulation of miR-181b may play an important role in the progress of gastric cancer and miR-181b maybe a potential molecular target for anticancer therapeutics of gastric cancer.
tissue_expression_up	hsa-mir-181b-2	Gastric Neoplasms	21876743	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Doxifluridine/Oxaliplatin treated advanced stage gastric cancer patients. The expression of miR-181b and miR-21 was significantly overexpressed in gastric tumors compared to normal gastric tissues.
tissue_expression_up	hsa-mir-181b-2	Gastric Neoplasms	22901205	disease of cellular proliferation	DOID:10534	C16	D013274	137215		The upregulation of miR-181b may play an important role in the progress of gastric cancer and miR-181b maybe a potential molecular target for anticancer therapeutics of gastric cancer.
tissue_expression_up	hsa-mir-181c	Gastric Neoplasms	23803080	disease of cellular proliferation	DOID:10534	C16	D013274	137215		The expression of miR-181c is upregulated in GC tissues and plasma, and the miR-181c expression level in GC plasma is positively correlated to that in the corresponding cancer tissues. Plasma miR-181c is possibly a new serological marker for GC diagnosis.
tissue_expression_up	hsa-mir-187	Gastric Neoplasms	22169097	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Genome-wide miRNA expression profiles followed with Real-Time quantitative RT-PCR (qRT-PCR) assays revealed that miR-187(*), miR-371-5p and miR-378 were significantly elevated in GC patients. Further validation indicated that miR-378 alone could yields a ROC curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating GC patients from healthy controls.
tissue_expression_up	hsa-mir-18a	Gastric Neoplasms	25416437	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-18a may be a promising biomarker for the detection of gastric cancer and its upregulation may be potentially associated with unfavorable prognosis of bladder cancer, suggesting that miR-18a might serve as a potential biological marker for further risk stratification in the management of gastric cancer.
tissue_expression_up	hsa-mir-18a	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-18a: overexpressed
tissue_expression_up	hsa-mir-18b	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-18b: overexpressed
tissue_expression_up	hsa-mir-191	Gastric Neoplasms	16461460	disease of cellular proliferation	DOID:10534	C16	D013274	137215		overexpressed
tissue_expression_up	hsa-mir-191	Gastric Neoplasms	22407237	disease of cellular proliferation	DOID:10534	C16	D013274	137215		In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients.
tissue_expression_up	hsa-mir-192	Gastric Neoplasms	24981590	disease of cellular proliferation	DOID:10534	C16	D013274	137215		These data suggest that frequently up-regulated miR-215/192 in gastric cancer may participate in gastric cancer progression.
tissue_expression_up	hsa-mir-192	Gastric Neoplasms	21119604	disease of cellular proliferation	DOID:10534	C16	D013274	137215		MicroRNA-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro.
tissue_expression_up	hsa-mir-194	Gastric Neoplasms	25412959	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-194 overexpression or RBX1 lowexpression was associated with prolonged survival of GC patients. In conclusion, upregulation of miR-194 can inhibit proliferation, migration, and invasion of GC cells, possibly by targeting RBX1. Aberrant expression of miR-194  and RBX1 is correlated to GC patient survival time.
tissue_expression_up	hsa-mir-195	Gastric Neoplasms	22046085	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Three miRs, miR-451, miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P < 0.0002, 0.0027 and 0.0046 respectively). High expression of each miR was associated with poorer prognosis for both recurrence and survival. Using miR-451, the positive predictive value for non-recurrence was 100% (13/13).
tissue_expression_up	hsa-mir-196a	Gastric Neoplasms	25374225	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Association of miR-193b down-regulation and miR-196a up-regulation with clinicopathological features andprognosis in gastric cancer.
tissue_expression_up	hsa-mir-196a-1	Gastric Neoplasms	22407237	disease of cellular proliferation	DOID:10534	C16	D013274	137215		In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients.
tissue_expression_up	hsa-mir-196a-1	Gastric Neoplasms	22420029	disease of cellular proliferation	DOID:10534	C16	D013274	137215		The expression level of miR-196a microRNA significantly increased in primary gastric cancer tissues versus adjacent normal tissues. In addition, extracellular miR-196a detected in conditioned medium was strongly correlated with its cellular expression status and increased circulating miR-196a in patient serum was associated with gastric cancer disease status and relapse.
tissue_expression_up	hsa-mir-196a-2	Gastric Neoplasms	22407237	disease of cellular proliferation	DOID:10534	C16	D013274	137215		In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients.
tissue_expression_up	hsa-mir-196a-2	Gastric Neoplasms	22420029	disease of cellular proliferation	DOID:10534	C16	D013274	137215		The expression level of miR-196a microRNA significantly increased in primary gastric cancer tissues versus adjacent normal tissues. In addition, extracellular miR-196a detected in conditioned medium was strongly correlated with its cellular expression status and increased circulating miR-196a in patient serum was associated with gastric cancer disease status and relapse.
tissue_expression_up	hsa-mir-199a-1	Gastric Neoplasms	22046085	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Three miRs, miR-451, miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P < 0.0002, 0.0027 and 0.0046 respectively). High expression of each miR was associated with poorer prognosis for both recurrence and survival. Using miR-451, the positive predictive value for non-recurrence was 100% (13/13).
tissue_expression_up	hsa-mir-199a-2	Gastric Neoplasms	22046085	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Three miRs, miR-451, miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P < 0.0002, 0.0027 and 0.0046 respectively). High expression of each miR was associated with poorer prognosis for both recurrence and survival. Using miR-451, the positive predictive value for non-recurrence was 100% (13/13).
tissue_expression_up	hsa-mir-19a	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-19a: overexpressed
tissue_expression_up	hsa-mir-200b	Gastric Neoplasms	23851184	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22.
tissue_expression_up	hsa-mir-20a	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-20a: overexpressed
tissue_expression_up	hsa-mir-20b	Gastric Neoplasms	19148490	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-20b: patients with high expression levels have lower survival time
tissue_expression_up	hsa-mir-20b	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-20b: overexpressed
tissue_expression_up	hsa-mir-21	Gastric Neoplasms	23888942	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR-21.
tissue_expression_up	hsa-mir-21	Gastric Neoplasms	26209976	disease of cellular proliferation	DOID:10534	C16	D013274	137215		It seems that miR-21 and miR-221 expression pattern in Iranian patients with gastric cancer are similar to any other population. Considering the increased expression level of two miRNAs in cancerous tissue compared to normal tissue as well as the area under ROC curve, miR-21 and miR-221 can be used for early detection of gastric cancer.
tissue_expression_up	hsa-mir-21	Gastric Neoplasms	16461460	disease of cellular proliferation	DOID:10534	C16	D013274	137215		overexpressed
tissue_expression_up	hsa-mir-21	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-21: overexpressed
tissue_expression_up	hsa-mir-21	Gastric Neoplasms	20372781	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Expression of miR-21 in cancer tissues was significantly higher than in non-cancer tissues
tissue_expression_up	hsa-mir-21	Gastric Neoplasms	21876743	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Doxifluridine/Oxaliplatin treated advanced stage gastric cancer patients. The expression of miR-181b and miR-21 was significantly overexpressed in gastric tumors compared to normal gastric tissues.
tissue_expression_up	hsa-mir-21	Gastric Neoplasms	22374783	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs.
tissue_expression_up	hsa-mir-21	Gastric Neoplasms	22407237	disease of cellular proliferation	DOID:10534	C16	D013274	137215		In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients.
tissue_expression_up	hsa-mir-21	Gastric Neoplasms	22638884	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control (P < 0.001), and its sensitivity and specificity were significantly higher than the currently used tumor markers.
tissue_expression_up	hsa-mir-21	Gastric Neoplasms	26824898	disease of cellular proliferation	DOID:10534	C16	D013274	137215		hsa-miR-21-5p was more highly expressed in the recurrence group than in the nonrecurrence group
tissue_expression_up	hsa-mir-21	Gastric Neoplasms	27179559	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-21 is overexpressed in tumour tissue
tissue_expression_up	hsa-mir-21	Gastric Neoplasms	29142602	disease of cellular proliferation	DOID:10534	C16	D013274	137215		there was a higher expression of VEGF and miR-21 in GC tissues compared with that in morphologically adjacent normal tissues whereas PPARα expression was decreased
tissue_expression_up	hsa-mir-214	Gastric Neoplasms	16461460	disease of cellular proliferation	DOID:10534	C16	D013274	137215		overexpressed
tissue_expression_up	hsa-mir-214	Gastric Neoplasms	20022810	disease of cellular proliferation	DOID:10534	C16	D013274	137215		high expression
tissue_expression_up	hsa-mir-215	Gastric Neoplasms	23981575	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1.
tissue_expression_up	hsa-mir-215	Gastric Neoplasms	24981590	disease of cellular proliferation	DOID:10534	C16	D013274	137215		These data suggest that frequently up-regulated miR-215/192 in gastric cancer may participate in gastric cancer progression.
tissue_expression_up	hsa-mir-215	Gastric Neoplasms	21119604	disease of cellular proliferation	DOID:10534	C16	D013274	137215		MicroRNA-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro.
tissue_expression_up	hsa-mir-218	Gastric Neoplasms	25694126	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Thermo-chemotherapy Induced miR-218 upregulation inhibits the invasion of gastric cancer via targeting Gli2 and E-cadherin.
tissue_expression_up	hsa-mir-22	Gastric Neoplasms	23851184	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22.
tissue_expression_up	hsa-mir-221	Gastric Neoplasms	26209976	disease of cellular proliferation	DOID:10534	C16	D013274	137215		It seems that miR-21 and miR-221 expression pattern in Iranian patients with gastric cancer are similar to any other population. Considering the increased expression level of two miRNAs in cancerous tissue compared to normal tissue as well as the area under ROC curve, miR-21 and miR-221 can be used for early detection of gastric cancer.
tissue_expression_up	hsa-mir-221	Gastric Neoplasms	16461460	disease of cellular proliferation	DOID:10534	C16	D013274	137215		overexpressed
tissue_expression_up	hsa-mir-221	Gastric Neoplasms	22613407	disease of cellular proliferation	DOID:10534	C16	D013274	137215		MiR-221 was up-regulated in 88% (81/92) of gastric cancer tissue samples compared with their paired adjacent nontumour tissue samples. High expression of miR-221 showed a significant correlation with advanced tumour-node-metastasis stage, local invasion and lymphatic metastasis.
tissue_expression_up	hsa-mir-223	Gastric Neoplasms	16461460	disease of cellular proliferation	DOID:10534	C16	D013274	137215		overexpressed
tissue_expression_up	hsa-mir-24-1	Gastric Neoplasms	16461460	disease of cellular proliferation	DOID:10534	C16	D013274	137215		overexpressed
tissue_expression_up	hsa-mir-24-2	Gastric Neoplasms	16461460	disease of cellular proliferation	DOID:10534	C16	D013274	137215		overexpressed
tissue_expression_up	hsa-mir-25	Gastric Neoplasms	16461460	disease of cellular proliferation	DOID:10534	C16	D013274	137215		overexpressed
tissue_expression_up	hsa-mir-26b	Gastric Neoplasms	22407237	disease of cellular proliferation	DOID:10534	C16	D013274	137215		In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients.
tissue_expression_up	hsa-mir-301a	Gastric Neoplasms	23832550	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-301a overexpression correlated with TNM stage and prognosis,suggesting that miR-301a is involved in cellular clone formation, migration, and invasion in vitro and may play an important role in the clinical progression and prognosis of gastric cancer.
tissue_expression_up	hsa-mir-302a	Gastric Neoplasms	22374783	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs.
tissue_expression_up	hsa-mir-302b	Gastric Neoplasms	22374783	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs.
tissue_expression_up	hsa-mir-302c	Gastric Neoplasms	22374783	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs.
tissue_expression_up	hsa-mir-302d	Gastric Neoplasms	22374783	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs.
tissue_expression_up	hsa-mir-302e	Gastric Neoplasms	22374783	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs.
tissue_expression_up	hsa-mir-302f	Gastric Neoplasms	22374783	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs.
tissue_expression_up	hsa-mir-30b	Gastric Neoplasms	22407237	disease of cellular proliferation	DOID:10534	C16	D013274	137215		In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients.
tissue_expression_up	hsa-mir-340	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-340*: overexpressed
tissue_expression_up	hsa-mir-34b	Gastric Neoplasms	19148490	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-34b: upregulated in undifferentiated gastric cancer
tissue_expression_up	hsa-mir-34c	Gastric Neoplasms	19148490	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-34c: upregulated in undifferentiated gastric cancer
tissue_expression_up	hsa-mir-371a	Gastric Neoplasms	22169097	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Genome-wide miRNA expression profiles followed with Real-Time quantitative RT-PCR (qRT-PCR) assays revealed that miR-187(*), miR-371-5p and miR-378 were significantly elevated in GC patients. Further validation indicated that miR-378 alone could yields a ROC curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating GC patients from healthy controls.
tissue_expression_up	hsa-mir-372	Gastric Neoplasms	22374783	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs.
tissue_expression_up	hsa-mir-373	Gastric Neoplasms	22374783	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs.
tissue_expression_up	hsa-mir-374b	Gastric Neoplasms	25516656	disease of cellular proliferation	DOID:10534	C16	D013274	137215		upregulation of miR-374b-5p contributes to gastric cancer cell metastasis and invasion through inhibition of RECK expression.
tissue_expression_up	hsa-mir-375	Gastric Neoplasms	21343377	disease of cellular proliferation	DOID:10534	C16	D013274	137215		A high frequency recurrence and poor survival were observed in gastric cancer cases with high level of hsa-miR-375 and low level of hsa-miR-142-5p (P < 0.001). The results indicate that the combination of hsa-miR-375 and hsa-miR-142-5p as a predictor of disease progression has the potential to predict recurrence risk for GC patients.
tissue_expression_up	hsa-mir-378a	Gastric Neoplasms	22169097	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Genome-wide miRNA expression profiles followed with Real-Time quantitative RT-PCR (qRT-PCR) assays revealed that miR-187(*), miR-371-5p and miR-378 were significantly elevated in GC patients. Further validation indicated that miR-378 alone could yields a ROC curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating GC patients from healthy controls.
tissue_expression_up	hsa-mir-421	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-421: overexpressed
tissue_expression_up	hsa-mir-451a	Gastric Neoplasms	22046085	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Three miRs, miR-451, miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P < 0.0002, 0.0027 and 0.0046 respectively). High expression of each miR was associated with poorer prognosis for both recurrence and survival. Using miR-451, the positive predictive value for non-recurrence was 100% (13/13).
tissue_expression_up	hsa-mir-520c	Gastric Neoplasms	22374783	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs.
tissue_expression_up	hsa-mir-630	Gastric Neoplasms	24621930	disease of cellular proliferation	DOID:10534	C16	D013274	137215		Increased microRNA-630 expression in gastric cancer is associated with poor overall survival.
tissue_expression_up	hsa-mir-658	Gastric Neoplasms	19175831	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-658: overexpressed
tissue_expression_up	hsa-mir-874	Gastric Neoplasms	23800944	disease of cellular proliferation	DOID:10534	C16	D013274	137215		These results provide a mechanism by which AQP3 is upregulated, as well as highlight the importance of miR-874 in gastric cancer development and progression.
tissue_expression_up	hsa-mir-9-1	Gastric Neoplasms	22407237	disease of cellular proliferation	DOID:10534	C16	D013274	137215		In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients.
tissue_expression_up	hsa-mir-9-2	Gastric Neoplasms	22407237	disease of cellular proliferation	DOID:10534	C16	D013274	137215		In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients.
tissue_expression_up	hsa-mir-93	Gastric Neoplasms	22567743	disease of cellular proliferation	DOID:10534	C16	D013274	137215		miR-93 is highly elevated in gastric cancer, especially in advanced and metastasized gastric cancer, suggesting miR-93 may play critical roles in carcinogenesis of gastric cancer. Overexpression of miR-93 can serve as a novel prognostic marker for gastric cancer.
tissue_expression_up	hsa-mir-9-3	Gastric Neoplasms	22407237	disease of cellular proliferation	DOID:10534	C16	D013274	137215		In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients.
tissue_expression_up	hsa-mir-146b	Gastroduodenal Ulcer	25753878			K28				This study indicated that the up-regulation of miR-155 and miR-146b decreases H. pylori (cagA+)-introduced IL6 overexpression, which might weaken the cleanup of H. pylori (cagA+) and contributes to ulcer.
tissue_expression_up	hsa-mir-155	Gastroduodenal Ulcer	25753878			K28				This study indicated that the up-regulation of miR-155 and miR-146b decreases H. pylori (cagA+)-introduced IL6 overexpression, which might weaken the cleanup of H. pylori (cagA+) and contributes to ulcer.
tissue_expression_up	hsa-mir-103	Gastrointestinal Neoplasms	22996433			D37.9	D005770			The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis
tissue_expression_up	hsa-mir-106a	Gastrointestinal Neoplasms	22996433			D37.9	D005770			The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis
tissue_expression_up	hsa-mir-106b	Gastrointestinal Neoplasms	22996433			D37.9	D005770			The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis
tissue_expression_up	hsa-mir-130	Gastrointestinal Neoplasms	22996433			D37.9	D005770			The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis
tissue_expression_up	hsa-mir-142	Gastrointestinal Neoplasms	21343377			D37.9	D005770			A high frequency recurrence and poor survival were observed in GC cases with high level of hsa-miR-375 and low level of hsa-miR-142-5p (P < 0.001),indicating that the combination of hsa-miR-375 and hsa-miR-142-5p as a predictor of disease progression has the potential to predict recurrence risk for GC patients
tissue_expression_up	hsa-mir-17	Gastrointestinal Neoplasms	21743960			D37.9	D005770			Our study suggests that the presence of BM-DTCs and the upregulation of the miR-17-92 cluster in tumors are both significant but independent prognostic markers in gastrointestinal cancer patients.
tissue_expression_up	hsa-mir-18	Gastrointestinal Neoplasms	21743960			D37.9	D005770			Our study suggests that the presence of BM-DTCs and the upregulation of the miR-17-92 cluster in tumors are both significant but independent prognostic markers in gastrointestinal cancer patients.
tissue_expression_up	hsa-mir-19a	Gastrointestinal Neoplasms	21743960			D37.9	D005770			Our study suggests that the presence of BM-DTCs and the upregulation of the miR-17-92 cluster in tumors are both significant but independent prognostic markers in gastrointestinal cancer patients.
tissue_expression_up	hsa-mir-19b-1	Gastrointestinal Neoplasms	21743960			D37.9	D005770			Our study suggests that the presence of BM-DTCs and the upregulation of the miR-17-92 cluster in tumors are both significant but independent prognostic markers in gastrointestinal cancer patients.
tissue_expression_up	hsa-mir-20a	Gastrointestinal Neoplasms	21743960			D37.9	D005770			Our study suggests that the presence of BM-DTCs and the upregulation of the miR-17-92 cluster in tumors are both significant but independent prognostic markers in gastrointestinal cancer patients.
tissue_expression_up	hsa-mir-20a	Gastrointestinal Neoplasms	22996433			D37.9	D005770			The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis
tissue_expression_up	hsa-mir-221	Gastrointestinal Neoplasms	22996433			D37.9	D005770			The high expression of miR-222 and miR-221 showed correlation with shorter metastasis-free survival (P = 0.039 and 0.033,respectively), and miR-222 high expression was related to reduced overall survival (P = 0.012).
tissue_expression_up	hsa-mir-222	Gastrointestinal Neoplasms	22996433			D37.9	D005770			The high expression of miR-222 and miR-221 showed correlation with shorter metastasis-free survival (P = 0.039 and 0.033,respectively), and miR-222 high expression was related to reduced overall survival (P = 0.012).
tissue_expression_up	hsa-mir-223	Gastrointestinal Neoplasms	20802470			D37.9	D005770			Taken together, aberrant E2A expression is a diagnostic feature of a subtype of gastric MALT lymphoma with weaker plasmacytoid infiltrates and stronger miR-223 expression.
tissue_expression_up	hsa-mir-25	Gastrointestinal Neoplasms	22996433			D37.9	D005770			The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis
tissue_expression_up	hsa-mir-375	Gastrointestinal Neoplasms	21343377			D37.9	D005770			A high frequency recurrence and poor survival were observed in GC cases with high level of hsa-miR-375 and low level of hsa-miR-142-5p (P < 0.001),indicating that the combination of hsa-miR-375 and hsa-miR-142-5p as a predictor of disease progression has the potential to predict recurrence risk for GC patients
tissue_expression_up	hsa-mir-92-1	Gastrointestinal Neoplasms	21743960			D37.9	D005770			Our study suggests that the presence of BM-DTCs and the upregulation of the miR-17-92 cluster in tumors are both significant but independent prognostic markers in gastrointestinal cancer patients.
tissue_expression_up	hsa-mir-93	Gastrointestinal Neoplasms	22996433			D37.9	D005770			The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis
tissue_expression_up	hsa-mir-155	Gaucher Disease	26376862	disease of metabolism	DOID:1926	E75.22	D005776	230800		sustained up-regulation of miR-155
tissue_expression_up	hsa-mir-146a	Gerstmann-Straussler-Scheinker Syndrome	22043907	nervous system disease	DOID:4249	A81.82	D016098	137440		Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome.
tissue_expression_up	hsa-mir-27a	Glaucoma	26720444	nervous system disease	DOID:1686	H40	D005901	137750		miR-27a was significantly upregulated.
tissue_expression_up	hsa-mir-106a	Glioblastoma	21483847				D005909		HP:0100843	miR-106aa upregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma.
tissue_expression_up	hsa-mir-10b	Glioblastoma	22492962				D005909		HP:0100843	The levels of miR-10b and miR-21 are found significantly increased in the CSF (cerebrospinal fluid) of patients with glioblastoma and brain metastasis of breast and lung cancer, compared with tumors in remission and a variety of nonneoplastic conditions.
tissue_expression_up	hsa-mir-125b	Glioblastoma	24169356				D005909		HP:0100843	High-level expression of miR-125b is associated with poor outcomes of GMB. MiR-125b may have an oncogenic role in GMB cells by promoting cell proliferation and inhibiting apoptosis.
tissue_expression_up	hsa-mir-125b	Glioblastoma	29538610				D005909		HP:0100843	Upregulation of miR-125b, miR-181d, and miR-221 Predicts Poor Prognosis in MGMT Promoter-Unmethylated Glioblastoma Patients
tissue_expression_up	hsa-mir-128	Glioblastoma	27063952				D005909		HP:0100843	The three most over-expressed miRs in the non-differentiated GSCs compared to xenografts were miR-126, -137 and -128.
tissue_expression_up	hsa-mir-130b	Glioblastoma	26241672				D005909		HP:0100843	Upregulation of miR-130b enhances stem cell-like phenotype in glioblastoma by inactivating the Hippo signaling pathway.
tissue_expression_up	hsa-mir-137	Glioblastoma	22722712				D005909		HP:0100843	miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with both TMZ (temozolomide ) and OLE (Olea europaea leaf extract).
tissue_expression_up	hsa-mir-142	Glioblastoma	20380575				D005909		HP:0100843	miR-142-3p:The miR-17-3p, miR-17-5p, miR-19a, miR-19b, miR-142-3p, and miR-142-5p were upregulated in both M059K and M059J cells.
tissue_expression_up	hsa-mir-143	Glioblastoma	20380575				D005909		HP:0100843	miR-143:The miR-15a, miR-16, miR-143, miR-155, and miR-21 were upregulated in M059K
tissue_expression_up	hsa-mir-145	Glioblastoma	22722712				D005909		HP:0100843	miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with both TMZ (temozolomide ) and OLE (Olea europaea leaf extract).
tissue_expression_up	hsa-mir-145	Glioblastoma	23577178				D005909		HP:0100843	Most importantly, higher hsa-miR-145 expression in GBM tumors yielded significantly better survival (p<0.005) in a subset of patients thus validating it as a genuine tumor suppressor miRNA.
tissue_expression_up	hsa-mir-146b	Glioblastoma	21483847				D005909		HP:0100843	miR-146b upregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma.
tissue_expression_up	hsa-mir-148a	Glioblastoma	21483847				D005909		HP:0100843	miR-148a upregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma.
tissue_expression_up	hsa-mir-153-1	Glioblastoma	22722712				D005909		HP:0100843	miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with both TMZ (temozolomide ) and OLE (Olea europaea leaf extract).
tissue_expression_up	hsa-mir-153-2	Glioblastoma	22722712				D005909		HP:0100843	miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with both TMZ (temozolomide ) and OLE (Olea europaea leaf extract).
tissue_expression_up	hsa-mir-155	Glioblastoma	20380575				D005909		HP:0100843	miR-155:The miR-15a, miR-16, miR-143, miR-155, and miR-21 were upregulated in M059K
tissue_expression_up	hsa-mir-15a	Glioblastoma	20380575				D005909		HP:0100843	miR-15a:The miR-15a, miR-16, miR-143, miR-155, and miR-21 were upregulated in M059K
tissue_expression_up	hsa-mir-16	Glioblastoma	29110584				D005909		HP:0100843	Our data demonstrated a significant upregulation of five microRNAs (hsa-miR-16, hsa-miR-17, hsa-miR-21, hsa-miR-221, and hsa-miR-375)
tissue_expression_up	hsa-mir-16-1	Glioblastoma	20380575				D005909		HP:0100843	miR-16:The miR-15a, miR-16, miR-143, miR-155, and miR-21 were upregulated in M059K
tissue_expression_up	hsa-mir-16-2	Glioblastoma	20380575				D005909		HP:0100843	miR-16:The miR-15a, miR-16, miR-143, miR-155, and miR-21 were upregulated in M059K
tissue_expression_up	hsa-mir-17	Glioblastoma	20380575				D005909		HP:0100843	miR-17-3p:The miR-17-3p, miR-17-5p, miR-19a, miR-19b, miR-142-3p, and miR-142-5p were upregulated in both M059K and M059J cells.
tissue_expression_up	hsa-mir-17	Glioblastoma	21483847				D005909		HP:0100843	miR-17-5p upregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma.
tissue_expression_up	hsa-mir-17	Glioblastoma	23497354				D005909		HP:0100843	In glioblastoma a high ratio of miR-17 to miR-221/222 was predictive of better overall survival suggesting that high miR-221/222 expression is more adverse for patients than high miR-17 expression.
tissue_expression_up	hsa-mir-17	Glioblastoma	29110584				D005909		HP:0100843	Our data demonstrated a significant upregulation of five microRNAs (hsa-miR-16, hsa-miR-17, hsa-miR-21, hsa-miR-221, and hsa-miR-375)
tissue_expression_up	hsa-mir-181b-1	Glioblastoma	22722712				D005909		HP:0100843	miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with both TMZ (temozolomide ) and OLE (Olea europaea leaf extract).
tissue_expression_up	hsa-mir-181b-2	Glioblastoma	22722712				D005909		HP:0100843	miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with both TMZ (temozolomide ) and OLE (Olea europaea leaf extract).
tissue_expression_up	hsa-mir-181d	Glioblastoma	29538610				D005909		HP:0100843	Upregulation of miR-125b, miR-181d, and miR-221 Predicts Poor Prognosis in MGMT Promoter-Unmethylated Glioblastoma Patients
tissue_expression_up	hsa-mir-193a	Glioblastoma	21483847				D005909		HP:0100843	miR-193a upregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma.
tissue_expression_up	hsa-mir-197	Glioblastoma	26081814				D005909		HP:0100843	FUS1 acts as a tumor-suppressor gene by upregulating miR-197 in human glioblastoma.
tissue_expression_up	hsa-mir-19a	Glioblastoma	20380575				D005909		HP:0100843	miR-19a:The miR-17-3p, miR-17-5p, miR-19a, miR-19b, miR-142-3p, and miR-142-5p were upregulated in both M059K and M059J cells.
tissue_expression_up	hsa-mir-19b-1	Glioblastoma	20380575				D005909		HP:0100843	miR-19b:The miR-17-3p, miR-17-5p, miR-19a, miR-19b, miR-142-3p, and miR-142-5p were upregulated in both M059K and M059J cells.
tissue_expression_up	hsa-mir-19b-2	Glioblastoma	20380575				D005909		HP:0100843	miR-19b:The miR-17-3p, miR-17-5p, miR-19a, miR-19b, miR-142-3p, and miR-142-5p were upregulated in both M059K and M059J cells.
tissue_expression_up	hsa-mir-200b	Glioblastoma	21483847				D005909		HP:0100843	miR-200b upregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma.
tissue_expression_up	hsa-mir-21	Glioblastoma	26344589				D005909		HP:0100843	The results indicate that compound 1j can enhance apoptosis, retard proliferation, and up-regulate PDCD4, a target protein of miR-21. In addition,the compound 1j does not influence the expression of multiple miRNAs and the genes that participate in miRNA universal biosynthesis pathway. These results strongly support the assumption that title compounds can serve as a small molecule inhibitor of miR-21.
tissue_expression_up	hsa-mir-21	Glioblastoma	16024602				D005909		HP:0100843	upregulated
tissue_expression_up	hsa-mir-21	Glioblastoma	16039986				D005909		HP:0100843	upregulated
tissue_expression_up	hsa-mir-21	Glioblastoma	17531469				D005909		HP:0100843	MiR-21 is found to be highly expressed in numerous cancers like breast cancer, and glioblastoma and pancreatic cancer.
tissue_expression_up	hsa-mir-21	Glioblastoma	20380575				D005909		HP:0100843	miR-21:The miR-15a, miR-16, miR-143, miR-155, and miR-21 were upregulated in M059K
tissue_expression_up	hsa-mir-21	Glioblastoma	22492962				D005909		HP:0100843	The levels of miR-10b and miR-21 are found significantly increased in the CSF (cerebrospinal fluid) of patients with glioblastoma and brain metastasis of breast and lung cancer, compared with tumors in remission and a variety of nonneoplastic conditions.
tissue_expression_up	hsa-mir-21	Glioblastoma	29110584				D005909		HP:0100843	Our data demonstrated a significant upregulation of five microRNAs (hsa-miR-16, hsa-miR-17, hsa-miR-21, hsa-miR-221, and hsa-miR-375)
tissue_expression_up	hsa-mir-21	Glioblastoma	29559295				D005909		HP:0100843	In our microarray data, lower expression of miR-219-5p, miR-124, and miR-128 and higher expression of miR-21 was observed in GBM compared with the peripheral region, similar to the results of previous reports
tissue_expression_up	hsa-mir-210	Glioblastoma	25586423				D005909		HP:0100843	Acute hypoxia induces upregulation of microRNA-210 expression in glioblastoma spheroids.
tissue_expression_up	hsa-mir-221	Glioblastoma	20428775				D005909		HP:0100843	miR-221:STAT1/2 upregulation under the transcriptional control of INF-alpha signaling after knockdown of miR-221/222 cluster in U251 glioma cells
tissue_expression_up	hsa-mir-221	Glioblastoma	17627278				D005909		HP:0100843	Interestingly, high levels of miR-221&222 appear in glioblastomas and correlate with low levels of p27(Kip1) protein. Thus, deregulated expression of miR-221&222 promotes cancerous growth by inhibiting the expression of p27(Kip1).
tissue_expression_up	hsa-mir-221	Glioblastoma	23497354				D005909		HP:0100843	In glioblastoma a high ratio of miR-17 to miR-221/222 was predictive of better overall survival suggesting that high miR-221/222 expression is more adverse for patients than high miR-17 expression.
tissue_expression_up	hsa-mir-221	Glioblastoma	24155920				D005909		HP:0100843	A number of changes in the levels of microRNAs were detected in differentiating GICs, including over-expression of hsa-miR-21, hsa-miR-29a, hsa-miR-29b, hsa-miR-221 and hsa-miR-222, and down-regulation of hsa-miR-93 and hsa-miR-106a.
tissue_expression_up	hsa-mir-221	Glioblastoma	29110584				D005909		HP:0100843	Our data demonstrated a significant upregulation of five microRNAs (hsa-miR-16, hsa-miR-17, hsa-miR-21, hsa-miR-221, and hsa-miR-375)
tissue_expression_up	hsa-mir-221	Glioblastoma	29538610				D005909		HP:0100843	Upregulation of miR-125b, miR-181d, and miR-221 Predicts Poor Prognosis in MGMT Promoter-Unmethylated Glioblastoma Patients
tissue_expression_up	hsa-mir-222	Glioblastoma	20428775				D005909		HP:0100843	miR-222:STAT1/2 upregulation under the transcriptional control of INF-alpha signaling after knockdown of miR-221/222 cluster in U251 glioma cells
tissue_expression_up	hsa-mir-222	Glioblastoma	17627278				D005909		HP:0100843	Interestingly, high levels of miR-221&222 appear in glioblastomas and correlate with low levels of p27(Kip1) protein. Thus, deregulated expression of miR-221&222 promotes cancerous growth by inhibiting the expression of p27(Kip1).
tissue_expression_up	hsa-mir-222	Glioblastoma	24155920				D005909		HP:0100843	A number of changes in the levels of microRNAs were detected in differentiating GICs, including over-expression of hsa-miR-21, hsa-miR-29a, hsa-miR-29b, hsa-miR-221 and hsa-miR-222, and down-regulation of hsa-miR-93 and hsa-miR-106a.
tissue_expression_up	hsa-mir-27b	Glioblastoma	21922148				D005909		HP:0100843	Real-time PCR showed that miR-27b was up-regulated in glioma samples and glioma cells. Down-regulation of miR-27b triggered growth inhibition, induced apoptosis and inhibited invasion in glioma cells. In addition, Western blot assay showed that STAT3, c-myc and cyclin D1 were knocked down after treatment with miR-27b inhibitor.
tissue_expression_up	hsa-mir-3163	Glioblastoma	22074483				D005909		HP:0100843	Significantly deregulated miRNAs were miR-3163 (fold change 2.0, p = 0.05), miR-539 (fold change 0.5, p = 0.001), miR-1305 (fold change 0.5, p = 0.05), miR-1260 (fold change 0.5, p = 0.03) and let-7a (fold change 0.3, p = 0.02) after temozolomide treatment.
tissue_expression_up	hsa-mir-375	Glioblastoma	29110584				D005909		HP:0100843	Our data demonstrated a significant upregulation of five microRNAs (hsa-miR-16, hsa-miR-17, hsa-miR-21, hsa-miR-221, and hsa-miR-375)
tissue_expression_up	hsa-mir-4284	Glioblastoma	24732116				D005909		HP:0100843	A novel berbamine derivative inhibits cell viability and induces apoptosis in cancer stem-like cells of human glioblastoma, via up-regulation of miRNA-4284 and JNK/AP-1 signaling.
tissue_expression_up	hsa-mir-491	Glioblastoma	21831363				D005909		HP:0100843	miR-491-5p has high positive correlation with MMP-9 expression and its upregulation was demonstrated to reduce the levels of MMP-9 expression and inhibit cellular invasion in U251 and U87 glioma cells. Furthermore, miR-491-5p suppressed glioma cell invasion via targeting MMP-9 directly.
tissue_expression_up	hsa-mir-885	Glioblastoma	21831363				D005909		HP:0100843	miR-885-5p has high positive correlation with MMP-9 expression and its upregulation was demonstrated to reduce the levels of MMP-9 expression and inhibit cellular invasion in U251 and U87 glioma cells.
tissue_expression_up	hsa-mir-106a	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-106a	Glioma	26439036	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Elevated expression of miRNA-106a plays a crucial role in the development and progression of glioma, probably by promoting the proliferation and suppressing the apoptosis of glioma cells through the JNK/MAPK signaling pathway.
tissue_expression_up	hsa-mir-106b	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-106b	Glioma	22825541	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Upregulation of miR-20a and miR-106b is involved in the acquisition of malignancy of pediatric brainstem gliomas.
tissue_expression_up	hsa-mir-107	Glioma	23811124	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Low-expression of microRNA-107 inhibits cell apoptosis in glioma by upregulation of SALL4.
tissue_expression_up	hsa-mir-10b	Glioma	25773393	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Correlation of microRNA-10b upregulation and poor prognosis in human gliomas.
tissue_expression_up	hsa-mir-10b	Glioma	26988656	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Expression levels of miR-10b in glioma tissue were significantly higher than in normal brain tissue
tissue_expression_up	hsa-mir-125b	Glioma	25502291	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Higher expressions of miR-125b and miR-222 have also been proved to be associated with glioma. Furthermore, glioma patients with higher miR-125b, miR-221, and miR-222 expression were manifested to have poorer prognostic status, which might be attributed to their attenuated sensitivity to chemotherapy and radiotherapy.
tissue_expression_up	hsa-mir-125b-1	Glioma	22360855	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	The levels of miRNA-125b and MMP9 were significantly higher in SU3 and SU2, also a highly invasive GSCPs we established before, than in U251s.
tissue_expression_up	hsa-mir-132	Glioma	25234714	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Upregulation of miR-132 expression in glioma and its clinical significance.
tissue_expression_up	hsa-mir-15a	Glioma	28060761	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Sensitivity and specificity analysis indicated miR-15a, miR-16, miR-21, miR-23a, and miR-9 were up-regulated, while miR-124 was down-regulated in glioma
tissue_expression_up	hsa-mir-15b	Glioma	26191187	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Up-regulation of microRNA-15b correlates with unfavorable prognosis and malignant progression of human glioma.
tissue_expression_up	hsa-mir-16	Glioma	28060761	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Sensitivity and specificity analysis indicated miR-15a, miR-16, miR-21, miR-23a, and miR-9 were up-regulated, while miR-124 was down-regulated in glioma
tissue_expression_up	hsa-mir-17	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-17	Glioma	23226946	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Increased Expression of microRNA-17 Predicts Poor Prognosis in Human Glioma
tissue_expression_up	hsa-mir-182	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-182	Glioma	22788545	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	The concentration of miRNA-182 in glioma patients was found to be 3.1 times as high as that in healthy persons, a conclusion in excellent agreement with a separate qPCR measurement of the expression level.
tissue_expression_up	hsa-mir-183	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-183	Glioma	23263745	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	MicroRNA-183 upregulates HIF-1a by targeting isocitrate dehydrogenase 2 (IDH2) in glioma cells
tissue_expression_up	hsa-mir-183	Glioma	27215622	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	In conclusion, our study indicated that miR-183 was upregulated in glioma, and that  it may be used as a potential biomarker of poor prognosis in patients with glioma.
tissue_expression_up	hsa-mir-184	Glioma	25277131	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR-184 upregulation enhanced the malignant phenotype of human glioma cancer cells by reducing FIH-1 protein expression.
tissue_expression_up	hsa-mir-18a	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-18b	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-196a	Glioma	26261539	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Our results suggested that both high-miR-196a and low-miR-367 expression may be associated with aggressive progression and unfavorable clinical outcome in glioma patients. And combination of high-miR-196a and low-miR-367 expression may be a novel biomarker in identifying a poor prognosis group of high-grade glioma.
tissue_expression_up	hsa-mir-19a	Glioma	23824915	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR-19a and miR-19b overexpression in gliomas.
tissue_expression_up	hsa-mir-19a	Glioma	29658967	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	low expression  of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-528 in low-grade glioma
tissue_expression_up	hsa-mir-19b	Glioma	23824915	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR-19a and miR-19b overexpression in gliomas.
tissue_expression_up	hsa-mir-19b	Glioma	29658967	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	low expression  of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-529 in low-grade glioma
tissue_expression_up	hsa-mir-20a	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-20a	Glioma	22381757	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	The glioma tissues showed significantly up-regulated expression of miR-20a compared with normal brain tissues (P=0.035). The expression level of miR-20a was higher in high-grade than in low-grade gliomas. miR-20a mimics significantly enhanced the proliferation of U251 cells and the percentage of S-phase cells.
tissue_expression_up	hsa-mir-20a	Glioma	22825541	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Upregulation of miR-20a and miR-106b is involved in the acquisition of malignancy of pediatric brainstem gliomas.
tissue_expression_up	hsa-mir-20b	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-21	Glioma	22335906	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR-21 was up-regulated 1.49-fold in SHG-44(R) cells (Radioresistant cell line) relative to the SHG-44 cells.
tissue_expression_up	hsa-mir-21	Glioma	28060761	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Sensitivity and specificity analysis indicated miR-15a, miR-16, miR-21, miR-23a, and miR-9 were up-regulated, while miR-124 was down-regulated in glioma
tissue_expression_up	hsa-mir-210	Glioma	24382515	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	MicroRNA-210 overexpression predicts poorer prognosis in glioma patients.
tissue_expression_up	hsa-mir-218	Glioma	26133092	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Propofol suppresses proliferation and invasion of glioma cells by upregulating microRNA-218 expression.
tissue_expression_up	hsa-mir-221	Glioma	22681957	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma.
tissue_expression_up	hsa-mir-221	Glioma	25428536	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	There are a series of abnormal miRNA expressions in glioma. Among them, miR-221 and miR -222 are clustered miR s with elevated expressions. The over-expressions of miR-221 and miR-222 can be considered as new molecular tags for human glioma (Tab. 5, Fig. 4, Ref. 30).
tissue_expression_up	hsa-mir-221	Glioma	25502291	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Higher expressions of miR-125b and miR-222 have also been proved to be associated with glioma. Furthermore, glioma patients with higher miR-125b, miR-221, and miR-222 expression were manifested to have poorer prognostic status, which might be attributed to their attenuated sensitivity to chemotherapy and radiotherapy.
tissue_expression_up	hsa-mir-222	Glioma	22681957	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma.
tissue_expression_up	hsa-mir-222	Glioma	25428536	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	There are a series of abnormal miRNA expressions in glioma. Among them, miR-221 and miR -222 are clustered miR s with elevated expressions. The over-expressions of miR-221 and miR-222 can be considered as new molecular tags for human glioma (Tab. 5, Fig. 4, Ref. 30).
tissue_expression_up	hsa-mir-222	Glioma	25502291	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Higher expressions of miR-125b and miR-222 have also been proved to be associated with glioma. Furthermore, glioma patients with higher miR-125b, miR-221, and miR-222 expression were manifested to have poorer prognostic status, which might be attributed to their attenuated sensitivity to chemotherapy and radiotherapy.
tissue_expression_up	hsa-mir-224	Glioma	23263909	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Upregulation of microRNA-224 confers a poor prognosis in glioma patients
tissue_expression_up	hsa-mir-23a	Glioma	28060761	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Sensitivity and specificity analysis indicated miR-15a, miR-16, miR-21, miR-23a, and miR-9 were up-regulated, while miR-124 was down-regulated in glioma
tissue_expression_up	hsa-mir-24	Glioma	29658967	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	low expression  of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-530 in low-grade glioma
tissue_expression_up	hsa-mir-27a	Glioma	29658967	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	low expression  of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-531 in low-grade glioma
tissue_expression_up	hsa-mir-27b	Glioma	21922148	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Real-time PCR showed that miR-27b was up-regulated in glioma samples and glioma cells.
tissue_expression_up	hsa-mir-302a	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-302b	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-302c	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-302d	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-335	Glioma	22644918	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Tumor microRNA-335 expression is associated with poor prognosis in human glioma.
tissue_expression_up	hsa-mir-367	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-371a	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-372	Glioma	23298385	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Correlation of microRNA-372 upregulation with poor prognosis in human glioma.
tissue_expression_up	hsa-mir-373	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-527	Glioma	29658967	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	low expression  of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-533 in low-grade glioma
tissue_expression_up	hsa-mir-584	Glioma	29658967	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	low expression  of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-532 in low-grade glioma
tissue_expression_up	hsa-mir-9	Glioma	24122417	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Increased expression of microRNA-9 predicts an unfavorable prognosis in human glioma.
tissue_expression_up	hsa-mir-9	Glioma	28060761	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Sensitivity and specificity analysis indicated miR-15a, miR-16, miR-21, miR-23a, and miR-9 were up-regulated, while miR-124 was down-regulated in glioma
tissue_expression_up	hsa-mir-93	Glioma	20406893	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas,
tissue_expression_up	hsa-mir-93	Glioma	27185265	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	the upregulated miR-93 level was significantly associated with the advanced malignancy.
tissue_expression_up	hsa-mir-93	Glioma	28440610	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Evaluation Expression of Microrna-93 and Integrin Β8 in Different Types of Glioma Tumors
tissue_expression_up	hsa-mir-98	Glioma	24392454	disease of cellular proliferation	DOID:3070		D005910	PS137800	HP:0009733	Overexpression of RKIP inhibits cell invasion in glioma cell lines through upregulation of miR-98.
tissue_expression_up	hsa-mir-155	Graft-Versus-Host Disease	22408260			D89.813	D006086	614395		miR-155 up-regulation was shown in specimens from patients with pathological evidence of intestinal aGVHD (Acute graft-versus-host disease).
tissue_expression_up	hsa-let-7a-1	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	let-7a: overexpressed
tissue_expression_up	hsa-let-7a-2	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	let-7a: overexpressed
tissue_expression_up	hsa-let-7a-3	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	let-7a: overexpressed
tissue_expression_up	hsa-let-7b	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	let-7b: overexpressed
tissue_expression_up	hsa-let-7c	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	let-7c: overexpressed
tissue_expression_up	hsa-let-7d	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	let-7d: overexpressed
tissue_expression_up	hsa-let-7e	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	let-7e: overexpressed
tissue_expression_up	hsa-let-7f-1	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	let-7f: overexpressed
tissue_expression_up	hsa-let-7f-2	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	let-7f: overexpressed
tissue_expression_up	hsa-let-7g	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	let-7g: overexpressed
tissue_expression_up	hsa-let-7i	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	let-7i: overexpressed
tissue_expression_up	hsa-mir-101-1	Head And Neck Neoplasms	21560177	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_up	hsa-mir-101-2	Head And Neck Neoplasms	21560177	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_up	hsa-mir-1271	Head And Neck Neoplasms	21637912	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	hsa-mir-1271 was upregulated compared with normal tissue.
tissue_expression_up	hsa-mir-130b	Head And Neck Neoplasms	19351747	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-130b: up-regulated
tissue_expression_up	hsa-mir-130b	Head And Neck Neoplasms	22425712	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	up-regulation
tissue_expression_up	hsa-mir-142	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-142-3p: overexpressed
tissue_expression_up	hsa-mir-146b	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-146b: overexpressed
tissue_expression_up	hsa-mir-155	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-155: overexpressed
tissue_expression_up	hsa-mir-155	Head And Neck Neoplasms	22425712	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	up-regulation
tissue_expression_up	hsa-mir-181a-2	Head And Neck Neoplasms	19351747	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-181a: up-regulated
tissue_expression_up	hsa-mir-181a-2	Head And Neck Neoplasms	21637912	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	hsa-mir-181a-2* was upregulated compared with normal tissue.
tissue_expression_up	hsa-mir-181b-1	Head And Neck Neoplasms	19351747	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-181b: up-regulated
tissue_expression_up	hsa-mir-181b-1	Head And Neck Neoplasms	21560177	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_up	hsa-mir-181b-1	Head And Neck Neoplasms	21637912	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	hsa-mir-181b was upregulated compared with normal tissue.
tissue_expression_up	hsa-mir-181b-2	Head And Neck Neoplasms	19351747	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-181b: up-regulated
tissue_expression_up	hsa-mir-181b-2	Head And Neck Neoplasms	21560177	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_up	hsa-mir-181b-2	Head And Neck Neoplasms	21637912	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	hsa-mir-181b was upregulated compared with normal tissue.
tissue_expression_up	hsa-mir-181d	Head And Neck Neoplasms	19351747	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-181d: up-regulated
tissue_expression_up	hsa-mir-181d	Head And Neck Neoplasms	21560177	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_up	hsa-mir-18a	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-18: overexpressed
tissue_expression_up	hsa-mir-18a	Head And Neck Neoplasms	19351747	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-18a: up-regulated
tissue_expression_up	hsa-mir-18b	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-18: overexpressed
tissue_expression_up	hsa-mir-193b	Head And Neck Neoplasms	19351747	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-193b: up-regulated
tissue_expression_up	hsa-mir-195	Head And Neck Neoplasms	21560177	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_up	hsa-mir-200c	Head And Neck Neoplasms	23474763	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	expression of p21, miR-34a and miR-200c are increased, demonstrating functional p53 reactivation.
tissue_expression_up	hsa-mir-21	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-21: overexpressed
tissue_expression_up	hsa-mir-21	Head And Neck Neoplasms	19179615	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-21: is frequently overexpressed in human HNSCC
tissue_expression_up	hsa-mir-21	Head And Neck Neoplasms	19351747	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-21: up-regulated
tissue_expression_up	hsa-mir-21	Head And Neck Neoplasms	22425712	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	up-regulation
tissue_expression_up	hsa-mir-21	Head And Neck Neoplasms	22811001	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	The expression level of miR-21 was significantly up-regulated in plasma samples obtained from HNSCC patients (p<0.01) than those from healthy subjects, which were in consistent with our finding in HNSCC tissues.
tissue_expression_up	hsa-mir-221	Head And Neck Neoplasms	19351747	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-221: up-regulated
tissue_expression_up	hsa-mir-221	Head And Neck Neoplasms	21637912	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	hsa-mir-221* was upregulated compared with normal tissue.
tissue_expression_up	hsa-mir-223	Head And Neck Neoplasms	22425712	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	up-regulation
tissue_expression_up	hsa-mir-29c	Head And Neck Neoplasms	18798260	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-29c: overexpressed
tissue_expression_up	hsa-mir-31	Head And Neck Neoplasms	22425712	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	up-regulation
tissue_expression_up	hsa-mir-34a	Head And Neck Neoplasms	22629428	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	Dysregulation of microRNA-34a expression in head and neck squamous cell carcinoma promotes tumor growth and tumor angiogenesis.
tissue_expression_up	hsa-mir-34a	Head And Neck Neoplasms	23474763	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	expression of p21, miR-34a and miR-200c are increased, demonstrating functional p53 reactivation.
tissue_expression_up	hsa-mir-455	Head And Neck Neoplasms	19351747	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-455: up-regulated
tissue_expression_up	hsa-mir-491	Head And Neck Neoplasms	19351747	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	miR-491: up-regulated
tissue_expression_up	hsa-mir-744	Head And Neck Neoplasms	21637912	disease of cellular proliferation	DOID:11934	C76.0	D006258		HP:0012288	hsa-mir-744 was upregulated compared with normal tissue.
tissue_expression_up	hsa-let-7a-1	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-let-7a-2	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-let-7b	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-let-7c	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-let-7d	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-let-7e	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-let-7e	Heart Failure	21690488			I50	D006331		HP:0001635	The absolute expression levels of hcmv-miR-UL112, miR-296-5p, and let-7e were further determined in 127 patients and 67 control subjects (fold changes are 2.5, 0.5, and 1.7 respectively; all P<0.0001).
tissue_expression_up	hsa-let-7f-1	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-let-7f-2	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-1	Heart Failure	22735911			I50	D006331		HP:0001635	Some miRNAs highly expressed in the heart, such as miR-1,miR-133 and miR-208, are strongly associated with the development of cardiac hypertrophy, while the exact role of miR-21 in the cardiovascular system remains  controversial.
tissue_expression_up	hsa-mir-106b	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-10b	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-1-1	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-1-2	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-124	Heart Failure	23307820			I50	D006331		HP:0001635	The significant upregulation of miR-124 and miR-134 in the seizure-related stages and children suggested that both can be potential targets for anticonvulsant drugs in the epileptic developing brains, while the different expression patterns of miR-132 and miR-21 may suggest different functions in MTLE pathogenesis.
tissue_expression_up	hsa-mir-125a	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-126	Heart Failure	26162916			I50	D006331		HP:0001635	RV failure in PAH is associated with a specific molecular signature within the RV, contributing to a decrease in RV vascular density and promoting the progression to RV failure. More importantly, miR-126 upregulation in the RV improves microvessel density and RV function in experimental PAH.
tissue_expression_up	hsa-mir-126	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-129-2	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-130a	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-132	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-133	Heart Failure	22735911			I50	D006331		HP:0001635	Some miRNAs highly expressed in the heart, such as miR-1,miR-133 and miR-208, are strongly associated with the development of cardiac hypertrophy, while the exact role of miR-21 in the cardiovascular system remains  controversial.
tissue_expression_up	hsa-mir-134	Heart Failure	23307820			I50	D006331		HP:0001635	The significant upregulation of miR-124 and miR-134 in the seizure-related stages and children suggested that both can be potential targets for anticonvulsant drugs in the epileptic developing brains, while the different expression patterns of miR-132 and miR-21 may suggest different functions in MTLE pathogenesis.
tissue_expression_up	hsa-mir-181a	Heart Failure	27072074			I50	D006331		HP:0001635	In coronary sinus samples, the microRNAs miR-16-5p, miR-27a-3p, miR-27b-3p, miR-29b-3p, miR-29c-3p, miR-30e-5p, miR-92a-3p, miR-125b-5p, miR-140-5p, miR-195-5p, miR-424-5p, and miR-451a were significantly down-regulated, and let-7a-5p, let-7c-5p, let-7e-5p, miR-23b-3p, miR-107, miR-155-5p, miR-181a-5p, miR-181b-5p and miR-320a were up-regulated in heart failure.
tissue_expression_up	hsa-mir-195	Heart Failure	17108080			I50	D006331		HP:0001635	overexpressed
tissue_expression_up	hsa-mir-196a-1	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-196a-2	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-199b	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-200c	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-204	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-205	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-208	Heart Failure	22735911			I50	D006331		HP:0001635	Some miRNAs highly expressed in the heart, such as miR-1,miR-133 and miR-208, are strongly associated with the development of cardiac hypertrophy, while the exact role of miR-21 in the cardiovascular system remains  controversial.
tissue_expression_up	hsa-mir-208a	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-208b	Heart Failure	22859947			I50	D006331		HP:0001635	Increasing doses of doxorubicin, but not etoposide (a Topoisomerase II inhibitor devoid of cardiovascular toxicity), specifically induced the up-regulation of miR-208b, miR-216b, miR-215, miR-34c and miR-367 in rat hearts. 
tissue_expression_up	hsa-mir-21	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-21	Heart Failure	22735911			I50	D006331		HP:0001635	Some miRNAs highly expressed in the heart, such as miR-1,miR-133 and miR-208, are strongly associated with the development of cardiac hypertrophy, while the exact role of miR-21 in the cardiovascular system remains  controversial.
tissue_expression_up	hsa-mir-210	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-210	Heart Failure	23660476			I50	D006331		HP:0001635	miR-210 and miR-30a were elevated in the HF and fetus groups.
tissue_expression_up	hsa-mir-211	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-212	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-215	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-215	Heart Failure	22859947			I50	D006331		HP:0001635	Increasing doses of doxorubicin, but not etoposide (a Topoisomerase II inhibitor devoid of cardiovascular toxicity), specifically induced the up-regulation of miR-208b, miR-216b, miR-215, miR-34c and miR-367 in rat hearts. 
tissue_expression_up	hsa-mir-216a	Heart Failure	22427379			I50	D006331		HP:0001635	miR-216a was strongly increased in both D-HF (diabetic HF) and ND-HF (nondiabetic HF) patients, negatively correlated with left ventricular ejection fraction.
tissue_expression_up	hsa-mir-216b	Heart Failure	22859947			I50	D006331		HP:0001635	Increasing doses of doxorubicin, but not etoposide (a Topoisomerase II inhibitor devoid of cardiovascular toxicity), specifically induced the up-regulation of miR-208b, miR-216b, miR-215, miR-34c and miR-367 in rat hearts. 
tissue_expression_up	hsa-mir-26a-1	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-26a-2	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-28	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-296	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-297	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-29a	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-29b-1	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-300	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-302a	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-30a	Heart Failure	23660476			I50	D006331		HP:0001635	miR-210 and miR-30a were elevated in the HF and fetus groups.
tissue_expression_up	hsa-mir-32	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-320a	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-330	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-340	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-34b	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-34c	Heart Failure	22859947			I50	D006331		HP:0001635	Increasing doses of doxorubicin, but not etoposide (a Topoisomerase II inhibitor devoid of cardiovascular toxicity), specifically induced the up-regulation of miR-208b, miR-216b, miR-215, miR-34c and miR-367 in rat hearts. 
tissue_expression_up	hsa-mir-365a	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-365b	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-367	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-367	Heart Failure	22859947			I50	D006331		HP:0001635	Increasing doses of doxorubicin, but not etoposide (a Topoisomerase II inhibitor devoid of cardiovascular toxicity), specifically induced the up-regulation of miR-208b, miR-216b, miR-215, miR-34c and miR-367 in rat hearts. 
tissue_expression_up	hsa-mir-372	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-373	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-377	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-381	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-382	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-423	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-424	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-429	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-429	Heart Failure	26408546			I50	D006331		HP:0001635	17 miRNAs exhibited particularly high increases in expression, including miR-598, miR-429, miR-224, miR-425, and miR-221.
tissue_expression_up	hsa-mir-432	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-500a	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-520c	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-525	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-98	Heart Failure	17606841			I50	D006331		HP:0001635	upregulated
tissue_expression_up	hsa-mir-103a	Helicobacter pylori Infection	26945693			B96.81	D016480	600263	HP:0005202	miRNAs miR-103a-3p, miR-181c-5p, miR-370-3p, miR-375 and miR-223-3p were evaluated in tissue samples
tissue_expression_up	hsa-mir-181c	Helicobacter pylori Infection	26945693			B96.81	D016480	600263	HP:0005202	miRNAs miR-103a-3p, miR-181c-5p, miR-370-3p, miR-375 and miR-223-3p were evaluated in tissue samples
tissue_expression_up	hsa-mir-223	Helicobacter pylori Infection	26945693			B96.81	D016480	600263	HP:0005202	miRNAs miR-103a-3p, miR-181c-5p, miR-370-3p, miR-375 and miR-223-3p were evaluated in tissue samples
tissue_expression_up	hsa-mir-370	Helicobacter pylori Infection	26945693			B96.81	D016480	600263	HP:0005202	miRNAs miR-103a-3p, miR-181c-5p, miR-370-3p, miR-375 and miR-223-3p were evaluated in tissue samples
tissue_expression_up	hsa-mir-375	Helicobacter pylori Infection	26945693			B96.81	D016480	600263	HP:0005202	miRNAs miR-103a-3p, miR-181c-5p, miR-370-3p, miR-375 and miR-223-3p were evaluated in tissue samples
tissue_expression_up	hsa-mir-193b	Hematologic Neoplasms	19883314	disease of cellular proliferation	DOID:2531	C96.9	D019337		HP:0004377	miR-193b-365 significantly up-regulated in MM
tissue_expression_up	hsa-mir-122	Hepatitis B Virus Infection	21692939	disease by infectious agent	DOID:2043	B16/18	D006509	610424		Expression of the liver-specific miR-122 was significantly up-regulated in HBV-infected patients.
tissue_expression_up	hsa-mir-122	Hepatitis B Virus Infection	23221562	disease by infectious agent	DOID:2043	B16/18	D006509	610424		HBV mRNAs-mediated miR-122 inhibition up-regulates PTTG1-binding protein which promotes HCC tumor growth and cell invasion
tissue_expression_up	hsa-mir-130a	Hepatitis B Virus Infection	26871786	disease by infectious agent	DOID:2043	B16/18	D006509	610424		Upregulation of miRNA-130a Represents Good Prognosis in Patients With HBV-Related Acute-on-Chronic Liver Failure: A Prospective Study.
tissue_expression_up	hsa-mir-146a	Hepatitis B Virus Infection	19187610	disease by infectious agent	DOID:2043	B16/18	D006509	610424		miR-146a: up-regulated
tissue_expression_up	hsa-mir-181a-2	Hepatitis B Virus Infection	19187610	disease by infectious agent	DOID:2043	B16/18	D006509	610424		miR-181a: up-regulated
tissue_expression_up	hsa-mir-181b-1	Hepatitis B Virus Infection	19187610	disease by infectious agent	DOID:2043	B16/18	D006509	610424		miR-181b: up-regulated
tissue_expression_up	hsa-mir-181b-2	Hepatitis B Virus Infection	19187610	disease by infectious agent	DOID:2043	B16/18	D006509	610424		miR-181b: up-regulated
tissue_expression_up	hsa-mir-200a	Hepatitis B Virus Infection	19187610	disease by infectious agent	DOID:2043	B16/18	D006509	610424		miR-200: up-regulated
tissue_expression_up	hsa-mir-200b	Hepatitis B Virus Infection	19187610	disease by infectious agent	DOID:2043	B16/18	D006509	610424		miR-200: up-regulated
tissue_expression_up	hsa-mir-200c	Hepatitis B Virus Infection	19187610	disease by infectious agent	DOID:2043	B16/18	D006509	610424		miR-200: up-regulated
tissue_expression_up	hsa-mir-122	Hepatitis C Virus Infection	22114337	disease by infectious agent	DOID:1883	B19.2	D006526	609532		A high level of miR122 was expressed by lentiviral vector into human liver cell lines at a level comparable to the endogenous level in Huh7 cells. Among the cell lines we examined, Hep3B cells stably expressing miR122 (Hep3B/miR122) exhibited a significant enhancement of HCVcc propagation. Surprisingly, the productions of infectious particles in Hep3B/miR122 cells upon infection with HCVcc were comparable to those in Huh7 cells. Furthermore, a line of cured cells established by elimination of HCV RNA from the Hep3B/miR122 replicon cells exhibited an enhanced expression of miR122 and a continuous increase of infectious titers of HCVcc in every passage.
tissue_expression_up	hsa-mir-122	Hepatitis C Virus Infection	26272127	disease by infectious agent	DOID:1883	B19.2	D006526	609532		The levels  of miR-122 were higher in liver than those in blood from individuals infected with HCV genotypes 1 and 3
tissue_expression_up	hsa-mir-125b	Hepatitis C Virus Infection	27158204	disease by infectious agent	DOID:1883	B19.2	D006526	609532		In response to HCV core protein stimulation, cytokine production was up-regulated and miR-125b expression was down-regulated in THP-1 cells.
tissue_expression_up	hsa-mir-146a	Hepatitis C Virus Infection	27147737	disease by infectious agent	DOID:1883	B19.2	D006526	609532		miR-146a-5p level was consistently increased in HCV-infected hepatocyte-like cells
tissue_expression_up	hsa-mir-15b	Hepatitis C Virus Infection	16331254	disease by infectious agent	DOID:1883	B19.2	D006526	609532		overexpression
tissue_expression_up	hsa-mir-182	Hepatitis C Virus Infection	16331254	disease by infectious agent	DOID:1883	B19.2	D006526	609532		overexpression
tissue_expression_up	hsa-mir-192	Hepatitis C Virus Infection	27350618	disease by infectious agent	DOID:1883	B19.2	D006526	609532		miR-192 expression was induced by HCV infection
tissue_expression_up	hsa-mir-199b	Hepatitis C Virus Infection	16331254	disease by infectious agent	DOID:1883	B19.2	D006526	609532		overexpression
tissue_expression_up	hsa-mir-224	Hepatitis C Virus Infection	16331254	disease by infectious agent	DOID:1883	B19.2	D006526	609532		overexpression
tissue_expression_up	hsa-mir-27	Hepatitis C Virus Infection	23897856	disease by infectious agent	DOID:1883	B19.2	D006526	609532		Hepatitis C virus induced up-regulation of microRNA-27: a novel mechanism for hepatic steatosis.
tissue_expression_up	hsa-mir-758	Hepatitis C Virus Infection	25008898	disease by infectious agent	DOID:1883	B19.2	D006526	609532		Hepatitis C virus infection decreases the expression of Toll-like receptors 3 and 7 via upregulation of miR-758.
tissue_expression_up	hsa-mir-125a	Hepatoblastoma	19701500	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	upregulated
tissue_expression_up	hsa-mir-150	Hepatoblastoma	19701500	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	upregulated
tissue_expression_up	hsa-mir-214	Hepatoblastoma	19701500	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	upregulated
tissue_expression_up	hsa-mir-492	Hepatoblastoma	21319197	disease of cellular proliferation	DOID:687	C22.2	D018197		HP:0002884	MicroRNA-492 is processed from the keratin 19 gene and up-regulated in metastatic hepatoblastoma.
tissue_expression_up	hsa-let-7d	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls.
tissue_expression_up	hsa-mir-125	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls.
tissue_expression_up	hsa-mir-125a	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls.
tissue_expression_up	hsa-mir-149	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls.
tissue_expression_up	hsa-mir-186	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree
tissue_expression_up	hsa-mir-191	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls.
tissue_expression_up	hsa-mir-196b	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls.
tissue_expression_up	hsa-mir-199a	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree
tissue_expression_up	hsa-mir-214	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree
tissue_expression_up	hsa-mir-218	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls.
tissue_expression_up	hsa-mir-24	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls.
tissue_expression_up	hsa-mir-30c	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls.
tissue_expression_up	hsa-mir-342	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls.
tissue_expression_up	hsa-mir-374a	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree
tissue_expression_up	hsa-mir-374b	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree
tissue_expression_up	hsa-mir-452	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls.
tissue_expression_up	hsa-mir-454	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls.
tissue_expression_up	hsa-mir-487b	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree
tissue_expression_up	hsa-mir-532	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree
tissue_expression_up	hsa-mir-628	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree
tissue_expression_up	hsa-mir-874	HIV-Associated Lipodystrophy	25063777			E88.1	D039682			Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree
tissue_expression_up	hsa-mir-122	Human Immunodeficiency Virus Infection	25920531			B20	D015658	609423		our results revealed that the Vpr-upregulated expression of miR-122 is closely related to the stimulation of HCV 5' UTR activity and HCV replication by Vpr, providing new evidence for how HIV interacts with HCV during HIV/HCV co-infection.
tissue_expression_up	hsa-mir-24	Hyperglycemia	25814526	disease of metabolism	DOID:4195	E78.1	D006943		HP:0003074	Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor.
tissue_expression_up	hsa-mir-4532	Hypertension	27176897	cardiovascular system disease	DOID:10763	I10	D006973	145500	HP:0000822	4 were upregulated (miR鈥?18a, miR鈥?27, miR鈥?18e and miR鈥?532) and 2 downregulated (miR鈥?8 and miR鈥?35b) in SPE placentas compared with controls.
tissue_expression_up	hsa-mir-518a	Hypertension	27176897	cardiovascular system disease	DOID:10763	I10	D006973	145500	HP:0000822	4 were upregulated (miR鈥?18a, miR鈥?27, miR鈥?18e and miR鈥?532) and 2 downregulated (miR鈥?8 and miR鈥?35b) in SPE placentas compared with controls.
tissue_expression_up	hsa-mir-518e	Hypertension	27176897	cardiovascular system disease	DOID:10763	I10	D006973	145500	HP:0000822	4 were upregulated (miR鈥?18a, miR鈥?27, miR鈥?18e and miR鈥?532) and 2 downregulated (miR鈥?8 and miR鈥?35b) in SPE placentas compared with controls.
tissue_expression_up	hsa-mir-527	Hypertension	27176897	cardiovascular system disease	DOID:10763	I10	D006973	145500	HP:0000822	4 were upregulated (miR鈥?18a, miR鈥?27, miR鈥?18e and miR鈥?532) and 2 downregulated (miR鈥?8 and miR鈥?35b) in SPE placentas compared with controls.
tissue_expression_up	hsa-mir-133a-1	Hypertrophy	21893044				D006984			Hydrogen sulphide inhibits cardiomyocyte hypertrophy by up-regulating miR-133a
tissue_expression_up	hsa-mir-133a-2	Hypertrophy	21893044				D006984			Hydrogen sulphide inhibits cardiomyocyte hypertrophy by up-regulating miR-133a
tissue_expression_up	hsa-mir-182	Hypoxic-Ischemic Encephalopathy	26975828			P91.60	D020925			miRNA-182 was highly expressed in the pineal gland.
tissue_expression_up	hsa-mir-34	Idiopathic Pulmonary Fibrosis	27362652	respiratory system disease	DOID:0050156	J84.112	D054990	178500		miR-34a, miR-34b, and miR-34c, but not miR-20a, miR-29c, or miR-let-7f were significantly higher in type II AECs from IPF patients.
tissue_expression_up	hsa-mir-150	Infection [unspecific]	29391047				D007239			upregulated miR-21, miR-155, miR-150, and miR-221, as well as downregulated miR-143 and miR-125, all of them previously linked to other bacterial infections
tissue_expression_up	hsa-mir-155	Infection [unspecific]	29391047				D007239			upregulated miR-21, miR-155, miR-150, and miR-221, as well as downregulated miR-143 and miR-125, all of them previously linked to other bacterial infections
tissue_expression_up	hsa-mir-21	Infection [unspecific]	29391047				D007239			upregulated miR-21, miR-155, miR-150, and miR-221, as well as downregulated miR-143 and miR-125, all of them previously linked to other bacterial infections
tissue_expression_up	hsa-mir-221	Infection [unspecific]	29391047				D007239			upregulated miR-21, miR-155, miR-150, and miR-221, as well as downregulated miR-143 and miR-125, all of them previously linked to other bacterial infections
tissue_expression_up	hsa-let-7b	Infertility	24711889	reproductive system disease	DOID:5223	N46.9/N97.9	D007246			Mir-100, let-7b levels were significantly higher than those in control group (P=0.008 and P=0.009, respectively).
tissue_expression_up	hsa-mir-130b	Inflammation	23733276				D007249			Statistical analysis considering liver donor meta-data including correction for multiple testing revealed strongly elevated levels of miR-21, miR-34a, miR-130b, and miR-132 in cholestatic liver and of miR-21 and miR-130b during inflammation, as indicated by elevated C-reactive protein levels in serum.
tissue_expression_up	hsa-mir-132	Inflammation	23733276				D007249			Statistical analysis considering liver donor meta-data including correction for multiple testing revealed strongly elevated levels of miR-21, miR-34a, miR-130b, and miR-132 in cholestatic liver and of miR-21 and miR-130b during inflammation, as indicated by elevated C-reactive protein levels in serum.
tissue_expression_up	hsa-mir-132	Inflammation	23951048				D007249			Chronic ethanol feeding up-regulated miR-155 and miR-132 expression in mouse cerebellum.
tissue_expression_up	hsa-mir-146a	Inflammation	20098732				D007249			The expression of a few miRs including miR-146a and miR-455 was found to be significantly increased in response to TWEAK treatment. 
tissue_expression_up	hsa-mir-150	Inflammation	19525145				D007249			Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells.
tissue_expression_up	hsa-mir-150	Inflammation	22595106				D007249			Of the 335 human miRNAs identified in the pulp tissues, 3 miRNAs, miR-150, miR-584, and miR-766, were significantly up-regulated in inflamed pulps as compared with normal pulps
tissue_expression_up	hsa-mir-155	Inflammation	19525145				D007249			Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells.
tissue_expression_up	hsa-mir-17	Inflammation	19525145				D007249			Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells.
tissue_expression_up	hsa-mir-18	Inflammation	19525145				D007249			Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells.
tissue_expression_up	hsa-mir-181	Inflammation	19525145				D007249			Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells.
tissue_expression_up	hsa-mir-19a	Inflammation	19525145				D007249			Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells.
tissue_expression_up	hsa-mir-19b-1	Inflammation	19525145				D007249			Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells.
tissue_expression_up	hsa-mir-20a	Inflammation	19525145				D007249			Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells.
tissue_expression_up	hsa-mir-21	Inflammation	23733276				D007249			Statistical analysis considering liver donor meta-data including correction for multiple testing revealed strongly elevated levels of miR-21, miR-34a, miR-130b, and miR-132 in cholestatic liver and of miR-21 and miR-130b during inflammation, as indicated by elevated C-reactive protein levels in serum.
tissue_expression_up	hsa-mir-221	Inflammation	25926893				D007249			Interestingly, miR-221  (2-fold, P鈥?鈥?.002), miR-222 (2.5-fold, P鈥?鈥?.04), and miR-155 (5-fold, P鈥?鈥?.015) were increased in inflamed adipocytes
tissue_expression_up	hsa-mir-222	Inflammation	25926893				D007249			Interestingly, miR-221  (2-fold, P鈥?鈥?.002), miR-222 (2.5-fold, P鈥?鈥?.04), and miR-155 (5-fold, P鈥?鈥?.015) were increased in inflamed adipocytes
tissue_expression_up	hsa-mir-223	Inflammation	19525145				D007249			Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells.
tissue_expression_up	hsa-mir-34a	Inflammation	23733276				D007249			Statistical analysis considering liver donor meta-data including correction for multiple testing revealed strongly elevated levels of miR-21, miR-34a, miR-130b, and miR-132 in cholestatic liver and of miR-21 and miR-130b during inflammation, as indicated by elevated C-reactive protein levels in serum.
tissue_expression_up	hsa-mir-455	Inflammation	20098732				D007249			The expression of a few miRs including miR-146a and miR-455 was found to be significantly increased in response to TWEAK treatment. 
tissue_expression_up	hsa-mir-584	Inflammation	22595106				D007249			Of the 335 human miRNAs identified in the pulp tissues, 3 miRNAs, miR-150, miR-584, and miR-766, were significantly up-regulated in inflamed pulps as compared with normal pulps
tissue_expression_up	hsa-mir-766	Inflammation	22595106				D007249			Of the 335 human miRNAs identified in the pulp tissues, 3 miRNAs, miR-150, miR-584, and miR-766, were significantly up-regulated in inflamed pulps as compared with normal pulps
tissue_expression_up	hsa-mir-92-1	Inflammation	19525145				D007249			Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells.
tissue_expression_up	hsa-mir-132	Inflammatory Bowel Diseases	23598815	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	MiR-132 levels are higher in inflamed compared with apparently quiescent intestinal biopsies from patients with IBD.
tissue_expression_up	hsa-mir-132	Inflammatory Bowel Diseases	26878986	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	significant upregulation of miR-132  and miR-223 was confirmed
tissue_expression_up	hsa-mir-146a	Inflammatory Bowel Diseases	26752469	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	Expression of miR-146a and -155 was higher in the inflamed mucosa of children with CD and UC than in the intact mucosa. Expression of miR-122 elevated in the macroscopically intact colonic regions of CD compared with controls and patients with UC.
tissue_expression_up	hsa-mir-223	Inflammatory Bowel Diseases	26878986	gastrointestinal system disease	DOID:0050589		D015212	PS266600	HP:0002037	significant upregulation of miR-132  and miR-223 was confirmed
tissue_expression_up	hsa-mir-200c	Interstitial Lung Disease	27309544	respiratory system disease	DOID:3082	J84	D017563	614748	HP:0006530	The miR-200c level in the SSc group was significantly higher than in the DM/PM, pSS, and RA groups
tissue_expression_up	hsa-mir-668	Interstitial Lung Disease	22782705	respiratory system disease	DOID:3082	J84	D017563	614748	HP:0006530	upregulated
tissue_expression_up	hsa-mir-92b	Interstitial Lung Disease	22782705	respiratory system disease	DOID:3082	J84	D017563	614748	HP:0006530	upregulated
tissue_expression_up	hsa-mir-146b	Intestinal Schistosomiasis	23825609	disease by infectious agent	DOID:0050597	B65.1	D012554	181460		miRNAs exhibiting a peak expression in the late phase of infection (dpi 45), such as mmu-miR-223, mmu-miR-146a/b, mmu-miR-155, mmu-miR-34c, mmu-miR-199, and mmu-miR-134, may represent a molecular ignature of the development of schistosomal hepatopathy.
tissue_expression_up	hsa-mir-199	Irritable Bowel Syndrome	25681400	syndrome	DOID:9778	K58	D043183			Decreased miR-199 augments visceral pain in patients with IBS through translational upregulation of TRPV1.
tissue_expression_up	hsa-mir-15a	Ischemia-Reperfusion Injury	22783320				D015427			MicroRNA-15a/b are up-regulated in response to myocardial ischemia/reperfusion injury.
tissue_expression_up	hsa-mir-15b	Ischemia-Reperfusion Injury	22783320				D015427			MicroRNA-15a/b are up-regulated in response to myocardial ischemia/reperfusion injury.
tissue_expression_up	hsa-mir-21	Ischemia-Reperfusion Injury	25691473				D015427			miR-21 has been shown to be enriched in kidney tissue in mice and humans with acute kidney injury
tissue_expression_up	hsa-mir-21	Ischemia-Reperfusion Injury	23988020				D015427			Our results demonstrate that besides miR-21, miR-17-5p, and miR-106a are additionally activated during the maintenance and recovery phases of renal I/R injury.
tissue_expression_up	hsa-mir-21	Ischemia-Reperfusion Injury	26178499				D015427			Renal expressions of miR-21 and miR-106a were significantly elevated in ischemia 20 min and 30 min groups at  12 h and 24 h post-reperfusion
tissue_expression_up	hsa-mir-223	Ischemia-Reperfusion Injury	19104939				D015427			miR-223: miR-223 expression levels were greatly up-regulated in the livers after 75 min ischemia followed by 120 min reperfusion when compared to sham controls
tissue_expression_up	hsa-mir-31	Kaposi Sarcoma	21715310	disease of cellular proliferation	DOID:8632	C46	D012514			In the present study, we show that Kaposi sarcoma-associated herpesvirus (KSHV), the etiological agent of KS, induces global miRNA changes in lymphatic endothelial cells (LECs). Specifically, the miR-221/miR-222 cluster is down-regulated, whereas miR-31 is up-regulated.
tissue_expression_up	hsa-mir-31	Kawasaki Syndrome	25039241	immune system disease	DOID:13378	M30.3	D009080	611775		These results suggest that the decrease in FoxP3(+) Treg might be associated with decreased expression of miR-155, leading to aberrant SOCS1/STAT-5 signalling and overexpression of miR-31 in patients with acute KD.
tissue_expression_up	hsa-mir-486	Kideny Transplant Rejection	27323802			T86.11	D006084			iR-486-5p and its target PTEN/foxO3 mRNA were significantly overexpressed (p鈥?鈥?.01) and underexpressed (p鈥?鈥?.01)
tissue_expression_up	hsa-mir-630	Kidney Neoplasms	25031755	disease of cellular proliferation	DOID:263	C64	D007680			The study proves for the first time that miR-630 is upregulated in a majority of ccRCC patients. It also shows that miR-630 expression is an independent prognostic factor for patients with renal cancer, which might be a potential valuable biomarker for ccRCC.
tissue_expression_up	hsa-mir-223	Knee Osteoarthritis	24727161			M17	D020370	165720	HP:0005086	Peroxisomal dysfunction is associated with up-regulation of apoptotic cell death  via miR-223 induction in knee osteoarthritis patients with type 2 diabetes mellitus.
tissue_expression_up	hsa-mir-205	Laryngeal Neoplasms	22605671			C32.3	D007822			Upregulation
tissue_expression_up	hsa-mir-20b	Laryngeal Neoplasms	20806854			C32.3	D007822			upregulated by 3 multiple
tissue_expression_up	hsa-mir-21	Laryngeal Neoplasms	22320969			C32.3	D007822			Mir-21 was up-regulated in LSCCs and HSCCs compared to adjacent non-tumor tissues (P < 0.05), and the up-regulated expression of mir-21 was associated with clinical stage (P = 0.001), T classification (P = 0.007), pathologic differentiation (P = 0.025), and lymph node positivity (P = 0.002).
tissue_expression_up	hsa-mir-21	Laryngeal Neoplasms	22605671			C32.3	D007822			Upregulation
tissue_expression_up	hsa-mir-31	Laryngeal Neoplasms	20806854			C32.3	D007822			upregulated by 3 multiple
tissue_expression_up	hsa-mir-708	Laryngeal Neoplasms	22605671			C32.3	D007822			Upregulation
tissue_expression_up	hsa-mir-93	Laryngeal Neoplasms	20806854			C32.3	D007822			upregulated by 3 multiple
tissue_expression_up	hsa-mir-93	Laryngeal Neoplasms	22605671			C32.3	D007822			Upregulation
tissue_expression_up	hsa-mir-125b	Leukemia	23550646			C95	D007938	613065	HP:0001909	miRNAs such as miR-21, miR-125b, miR-155, miR-196, and miR-210 that are critical for the immune  response or hypoxia are often overexpressed in cancers and leukemias
tissue_expression_up	hsa-mir-155	Leukemia	23550646			C95	D007938	613065	HP:0001909	miRNAs such as miR-21, miR-125b, miR-155, miR-196, and miR-210 that are critical for the immune  response or hypoxia are often overexpressed in cancers and leukemias
tissue_expression_up	hsa-mir-15a	Leukemia	22449094			C95	D007938	613065	HP:0001909	Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells.
tissue_expression_up	hsa-mir-15a	Leukemia	26456833			C95	D007938	613065	HP:0001909	miR-223 and miR-15a were upregulated in 11/19 JMML bone marrow mononuclear cells harboring PTPN11 mutations
tissue_expression_up	hsa-mir-16-1	Leukemia	22449094			C95	D007938	613065	HP:0001909	Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells.
tissue_expression_up	hsa-mir-16-2	Leukemia	22449094			C95	D007938	613065	HP:0001909	Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells.
tissue_expression_up	hsa-mir-196	Leukemia	23550646			C95	D007938	613065	HP:0001909	miRNAs such as miR-21, miR-125b, miR-155, miR-196, and miR-210 that are critical for the immune  response or hypoxia are often overexpressed in cancers and leukemias
tissue_expression_up	hsa-mir-21	Leukemia	23550646			C95	D007938	613065	HP:0001909	miRNAs such as miR-21, miR-125b, miR-155, miR-196, and miR-210 that are critical for the immune  response or hypoxia are often overexpressed in cancers and leukemias
tissue_expression_up	hsa-mir-210	Leukemia	23550646			C95	D007938	613065	HP:0001909	miRNAs such as miR-21, miR-125b, miR-155, miR-196, and miR-210 that are critical for the immune  response or hypoxia are often overexpressed in cancers and leukemias
tissue_expression_up	hsa-mir-17	Leukemia, B-Cell	15944707			C91.31	D015448	151430		overexpression
tissue_expression_up	hsa-mir-18a	Leukemia, B-Cell	15944707			C91.31	D015448	151430		overexpression
tissue_expression_up	hsa-mir-19a	Leukemia, B-Cell	15944707			C91.31	D015448	151430		overexpression
tissue_expression_up	hsa-mir-19b-1	Leukemia, B-Cell	15944707			C91.31	D015448	151430		overexpression
tissue_expression_up	hsa-mir-20a	Leukemia, B-Cell	15944707			C91.31	D015448	151430		overexpression
tissue_expression_up	hsa-mir-92a-1	Leukemia, B-Cell	15944707			C91.31	D015448	151430		overexpression
tissue_expression_up	hsa-mir-182	Leukemia, Biphenotypic, Acute	20227111	disease of cellular proliferation	DOID:9953	C95.0	D015456		HP:0005531	miR-182:miR-584 and miR-182 upregulation in the CD34(+)CD38(-) fraction
tissue_expression_up	hsa-mir-584	Leukemia, Biphenotypic, Acute	20227111	disease of cellular proliferation	DOID:9953	C95.0	D015456		HP:0005531	miR-584:miR-584 and miR-182 upregulation in the CD34(+)CD38(-) fraction
tissue_expression_up	hsa-mir-132	Leukemia, Lymphocytic, Chronic, B-Cell	25645730	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	Increased chronic lymphocytic leukemia proliferation upon IgM stimulation is sustained by the upregulation of miR-132 and miR-212.
tissue_expression_up	hsa-mir-132	Leukemia, Lymphocytic, Chronic, B-Cell	26036258	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	The SIRT1/TP53 axis is activated upon B-cell receptor triggering via miR-132 up-regulation in chronic lymphocytic leukemia cells.
tissue_expression_up	hsa-mir-155	Leukemia, Lymphocytic, Chronic, B-Cell	22238073	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	SOCS1 is significantly up-regulated in Nutlin-3-treated p53(wild-type) B chronic lymphocytic leukemia (B-CLL) samples and shows an inverse correlation with miR-155.
tissue_expression_up	hsa-mir-212	Leukemia, Lymphocytic, Chronic, B-Cell	25645730	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	Increased chronic lymphocytic leukemia proliferation upon IgM stimulation is sustained by the upregulation of miR-132 and miR-212.
tissue_expression_up	hsa-mir-143	Leukemia, Lymphocytic, Chronic, B-Cell	23615967	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	Significant upregulation of miR-150, miR-29c, miR-143 and miR-223 and downregulation of miR-15a was found in mutated versus unmutated CLL, with miR-15a showing the highest fold difference.
tissue_expression_up	hsa-mir-150	Leukemia, Lymphocytic, Chronic, B-Cell	23615967	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	Significant upregulation of miR-150, miR-29c, miR-143 and miR-223 and downregulation of miR-15a was found in mutated versus unmutated CLL, with miR-15a showing the highest fold difference.
tissue_expression_up	hsa-mir-155	Leukemia, Lymphocytic, Chronic, B-Cell	27111859	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	miR-143 was downregulated and miR-155 was overexpressed in 13q-H.
tissue_expression_up	hsa-mir-223	Leukemia, Lymphocytic, Chronic, B-Cell	23615967	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	Significant upregulation of miR-150, miR-29c, miR-143 and miR-223 and downregulation of miR-15a was found in mutated versus unmutated CLL, with miR-15a showing the highest fold difference.
tissue_expression_up	hsa-mir-29c	Leukemia, Lymphocytic, Chronic, B-Cell	23615967	disease of cellular proliferation	DOID:1040	C91.1	D015451	151400	HP:0005550	Significant upregulation of miR-150, miR-29c, miR-143 and miR-223 and downregulation of miR-15a was found in mutated versus unmutated CLL, with miR-15a showing the highest fold difference.
tissue_expression_up	hsa-mir-32	Leukemia, Myeloid	21816906	disease of cellular proliferation	DOID:8692	C92	D007951		HP:0012324	MicroRNA-32 upregulation by 1,25-dihydroxyvitamin D3 in human myeloid leukemia cells leads to Bim targeting and inhibition of AraC-induced apoptosis.
tissue_expression_up	hsa-mir-155	Leukemia, Myeloid, Acute	19744129	disease of cellular proliferation	DOID:9119	C92.0	D015470		HP:0004820	Their aberrant expression has been associated with solid tumors and hematopoietic malignancies as suggested by the frequent deletion of mir-15a and mir-16-1 in chronic lymphocytic leukemia, the increased levels of mir-155 in diffuse large B-cell lymphomas and the increased levels of mir-181 in acute myeloid leukemia M1 and M2. 
tissue_expression_up	hsa-mir-23b	Leukemia, Myeloid, Acute	24828865	disease of cellular proliferation	DOID:9119	C92.0	D015470		HP:0004820	MicroRNA-26a-5p and microRNA-23b-3p up-regulate peroxiredoxin III in acute myeloid leukemia.
tissue_expression_up	hsa-mir-26a	Leukemia, Myeloid, Acute	24828865	disease of cellular proliferation	DOID:9119	C92.0	D015470		HP:0004820	MicroRNA-26a-5p and microRNA-23b-3p up-regulate peroxiredoxin III in acute myeloid leukemia.
tissue_expression_up	hsa-mir-328	Leukemia, Myeloid, Chronic	25948184	disease of cellular proliferation	DOID:8552	C92.1	D015464		HP:0005506	miR-328 has been successfully constructed and transfected into K562 cells, miR-328 inhibits the proliferation of K562 cells by up-regulation of C/EBPα.
tissue_expression_up	hsa-mir-107	Leukemia, Promyelocytic, Acute	22967415	disease of cellular proliferation	DOID:0060318	C92.4	D015473	612376	HP:0004836	The expression level of miR-15b, miR-16, miR-107, miR-223 and miR-342 in APL CR group were significantly upregulated compared with that of newly diagnosed APL groups (P < 0.05), while the expression level of miR-181a was significantly downregulated (P < 0.05).
tissue_expression_up	hsa-mir-15b	Leukemia, Promyelocytic, Acute	22967415	disease of cellular proliferation	DOID:0060318	C92.4	D015473	612376	HP:0004836	The expression level of miR-15b, miR-16, miR-107, miR-223 and miR-342 in APL CR group were significantly upregulated compared with that of newly diagnosed APL groups (P < 0.05), while the expression level of miR-181a was significantly downregulated (P < 0.05).
tissue_expression_up	hsa-mir-16	Leukemia, Promyelocytic, Acute	22967415	disease of cellular proliferation	DOID:0060318	C92.4	D015473	612376	HP:0004836	The expression level of miR-15b, miR-16, miR-107, miR-223 and miR-342 in APL CR group were significantly upregulated compared with that of newly diagnosed APL groups (P < 0.05), while the expression level of miR-181a was significantly downregulated (P < 0.05).
tissue_expression_up	hsa-mir-223	Leukemia, Promyelocytic, Acute	22967415	disease of cellular proliferation	DOID:0060318	C92.4	D015473	612376	HP:0004836	The expression level of miR-15b, miR-16, miR-107, miR-223 and miR-342 in APL CR group were significantly upregulated compared with that of newly diagnosed APL groups (P < 0.05), while the expression level of miR-181a was significantly downregulated (P < 0.05).
tissue_expression_up	hsa-mir-342	Leukemia, Promyelocytic, Acute	22967415	disease of cellular proliferation	DOID:0060318	C92.4	D015473	612376	HP:0004836	The expression level of miR-15b, miR-16, miR-107, miR-223 and miR-342 in APL CR group were significantly upregulated compared with that of newly diagnosed APL groups (P < 0.05), while the expression level of miR-181a was significantly downregulated (P < 0.05).
tissue_expression_up	hsa-mir-17	Leukemia-Lymphoma, Adult T-Cell	26231295			C91.51	D015459		HP:0005517	Upregulation of miRNA-17 and miRNA-19 is associated with unfavorable prognosis in patients with T-cell lymphoblastic lymphoma.
tissue_expression_up	hsa-mir-19	Leukemia-Lymphoma, Adult T-Cell	26231295			C91.51	D015459		HP:0005517	Upregulation of miRNA-17 and miRNA-19 is associated with unfavorable prognosis in patients with T-cell lymphoblastic lymphoma.
tissue_expression_up	hsa-mir-126	Leukemia-Lymphoma, Precursor B-Cell Lymphoblastic	17604727	disease of cellular proliferation	DOID:7061	C83.5	D015452			strongly expressed
tissue_expression_up	hsa-mir-146a	Lichen Planus	22139425	integumentary system disease	DOID:9201	L43	D008010	151620		Increased miRNA-146a and miRNA-155 expressions in oral lichen planus.
tissue_expression_up	hsa-mir-155	Lichen Planus	22139425	integumentary system disease	DOID:9201	L43	D008010	151620		Increased miRNA-146a and miRNA-155 expressions in oral lichen planus.
tissue_expression_up	hsa-mir-203	Lichen Planus	21943223	integumentary system disease	DOID:9201	L43	D008010	151620		Increased expression of miR-21 and miR-203, decreased expression of miR-125, and down-regulation of p53 and deltaNp63 RNA were seen in OLP compared to normal oral mucosa. When comparing microRNA expression to levels of p53 and p63 RNA, a significant negative correlation was seen between deltaNp63 and miR-203 and between miR-21 and p53, respectively.
tissue_expression_up	hsa-mir-21	Lichen Planus	21943223	integumentary system disease	DOID:9201	L43	D008010	151620		Increased expression of miR-21 and miR-203, decreased expression of miR-125, and down-regulation of p53 and deltaNp63 RNA were seen in OLP compared to normal oral mucosa. When comparing microRNA expression to levels of p53 and p63 RNA, a significant negative correlation was seen between deltaNp63 and miR-203 and between miR-21 and p53, respectively.
tissue_expression_up	hsa-mir-214	Liver Cirrhosis	22849305	endocrine system disease	DOID:5082	K74	D008103	215600	HP:0001394	miR-214-5p was upregulated in human and mouse livers in a fibrosis progression-dependent manner.
tissue_expression_up	hsa-mir-221	Liver Cirrhosis	22267590	endocrine system disease	DOID:5082	K74	D008103	215600	HP:0001394	MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis.
tissue_expression_up	hsa-mir-222	Liver Cirrhosis	22267590	endocrine system disease	DOID:5082	K74	D008103	215600	HP:0001394	MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis.
tissue_expression_up	hsa-mir-132	Liver Diseases, Alcoholic	22518321			K70.9	D008108			In this paper, we summarize the current knowledge of miRNAs in ALD and also report increased expression of miR-155 and miR-132 in the total liver as well as in isolated hepatocytes and KCs of alcohol-fed mice.
tissue_expression_up	hsa-mir-155	Liver Diseases, Alcoholic	22518321			K70.9	D008108			In this paper, we summarize the current knowledge of miRNAs in ALD and also report increased expression of miR-155 and miR-132 in the total liver as well as in isolated hepatocytes and KCs of alcohol-fed mice.
tissue_expression_up	hsa-mir-122	Liver Failure	21692939			K72	D017093	613070	HP:0001399	The expression levels of miR-122 and miR-194 correlated negatively with the age of patients with CHB (chronic hepatitis B) or ACLF (acute-on-chronic liver failure).
tissue_expression_up	hsa-mir-194-1	Liver Failure	21692939			K72	D017093	613070	HP:0001399	The expression levels of miR-122 and miR-194 correlated negatively with the age of patients with CHB (chronic hepatitis B) or ACLF (acute-on-chronic liver failure).
tissue_expression_up	hsa-mir-194-2	Liver Failure	21692939			K72	D017093	613070	HP:0001399	The expression levels of miR-122 and miR-194 correlated negatively with the age of patients with CHB (chronic hepatitis B) or ACLF (acute-on-chronic liver failure).
tissue_expression_up	hsa-mir-34	Liver Fibrosis	27387128			K74	D008103			Further studies showed that the miR-34a/SIRT1/p53 signaling pathway was  activated in hepatocytes but not in HSCs.
tissue_expression_up	hsa-mir-34a	Liver Fibrosis	27387128			K74	D008103			In the present study, using a CCl4-induced rat liver fibrosis model, we found that the miR-34a/SIRT1/p53 signaling pathway was activated and could be inhibited by SIRT1 activator SRT1720.
tissue_expression_up	hsa-mir-10b	Liver Neoplasms	21176238	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	overexpressed in side population of HCC cells compared to fetal liver cells
tissue_expression_up	hsa-mir-21	Liver Neoplasms	21176238	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	overexpressed in side population of HCC cells compared to fetal liver cells
tissue_expression_up	hsa-mir-210	Liver Neoplasms	21175813	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	upregulated after arsenic trioxide treatment in HepG-2 cells
tissue_expression_up	hsa-mir-24-1	Liver Neoplasms	21175813	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	upregulated after arsenic trioxide treatment in HepG-2 cells
tissue_expression_up	hsa-mir-24-2	Liver Neoplasms	21175813	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	upregulated after arsenic trioxide treatment in HepG-2 cells
tissue_expression_up	hsa-mir-29a	Liver Neoplasms	21175813	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	upregulated after arsenic trioxide treatment in HepG-2 cells miR-29a showed a positive therapeutic effect in liver cancer cells by inhibiting cell growth and inducing cell apoptosis, and PPM1D was confirmed to be the target gene of miR-29a.
tissue_expression_up	hsa-mir-30a	Liver Neoplasms	21175813	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	upregulated after arsenic trioxide treatment in HepG-2 cells
tissue_expression_up	hsa-mir-34c	Liver Neoplasms	21176238	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	miR-34c-3p is overexpressed in side population of HCC cells compared to fetal liver cells
tissue_expression_up	hsa-mir-372	Liver Neoplasms	20423907	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	microRNA-372:CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer
tissue_expression_up	hsa-mir-629	Liver Neoplasms	19946373	disease of cellular proliferation	DOID:916	C22.0	D008113		HP:0002896	upregulated
tissue_expression_up	hsa-mir-149	Lung Fibrosis	24641842	respiratory system disease	DOID:3770	J84.10	D011658	178500		Down-regulation of miR-149 and up-regulation of IL-6 might be involved in the progression of silica-induced pulmonary fibrosis; miR-149 could negatively regulate IL-6 expression.
tissue_expression_up	hsa-mir-199b	Lung Neoplasms	21563230	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. 
tissue_expression_up	hsa-let-7d	Lung Neoplasms	21563230	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. 
tissue_expression_up	hsa-let-7e	Lung Neoplasms	21563230	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. 
tissue_expression_up	hsa-mir-103a-1	Lung Neoplasms	20624269	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-103:we found significant overexpression of miR-103, miR-107, miR-301 and miR-338 in lung cancer cells as compared to HBECs
tissue_expression_up	hsa-mir-103a-2	Lung Neoplasms	20624269	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-103:we found significant overexpression of miR-103, miR-107, miR-301 and miR-338 in lung cancer cells as compared to HBECs
tissue_expression_up	hsa-mir-106a	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulation
tissue_expression_up	hsa-mir-107	Lung Neoplasms	20624269	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-107:we found significant overexpression of miR-103, miR-107, miR-301 and miR-338 in lung cancer cells as compared to HBECs
tissue_expression_up	hsa-mir-10b	Lung Neoplasms	22492962	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	The levels of miR-10b and miR-21 are found significantly increased in the CSF (cerebrospinal fluid) of patients with glioblastoma and brain metastasis of breast and lung cancer, compared with tumors in remission and a variety of nonneoplastic conditions.
tissue_expression_up	hsa-mir-126	Lung Neoplasms	20418022	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	This set includes hsa-miR-182, which was most strongly over-expressed in the lung primary tumors, and hsa-miR-126, which was over-expressed in the metastatic tumors.
tissue_expression_up	hsa-mir-128-2	Lung Neoplasms	16461460	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	overexpressed
tissue_expression_up	hsa-mir-130a	Lung Neoplasms	19748927	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-21, mir-31, miR-130a, miR-146b and miR-377 were consistently upregulated, whereas miR-1 and miR-143 were downregulated in lung tumors relative to normal lungs.
tissue_expression_up	hsa-mir-133b	Lung Neoplasms	21648427	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Mice treated with pre-miR-133b containing lipoplexes had mature miR-133b expression in lung ~52-fold higher than untreated mice. 
tissue_expression_up	hsa-mir-136	Lung Neoplasms	20237410	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	We found that miR-136, miR-376a, and miR-31 were each prominently overexpressed in murine lung cancers.
tissue_expression_up	hsa-mir-143	Lung Neoplasms	23904792	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	The up-regulated miR-143 in lung cancer could significantly inhibit  cell migration and invasion, and this might work through targeting CD44v3, which  was newly identified by us.
tissue_expression_up	hsa-mir-146a	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulation
tissue_expression_up	hsa-mir-146b	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulation
tissue_expression_up	hsa-mir-146b	Lung Neoplasms	19748927	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-21, mir-31, miR-130a, miR-146b and miR-377 were consistently upregulated, whereas miR-1 and miR-143 were downregulated in lung tumors relative to normal lungs.
tissue_expression_up	hsa-mir-148b	Lung Neoplasms	21563230	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. 
tissue_expression_up	hsa-mir-150	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulation
tissue_expression_up	hsa-mir-155	Lung Neoplasms	25603615	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	The current paper on Meta-analysis demonstrated a correlation between the high expression of miRNA-155 and the outcome of patients with non-small cell  lung cancer.
tissue_expression_up	hsa-mir-155	Lung Neoplasms	16461460	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	overexpressed
tissue_expression_up	hsa-mir-155	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulation
tissue_expression_up	hsa-mir-17	Lung Neoplasms	16461460	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	overexpressed
tissue_expression_up	hsa-mir-17	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulation
tissue_expression_up	hsa-mir-17	Lung Neoplasms	19597473	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-17-5p ; frequent overexpression
tissue_expression_up	hsa-mir-182	Lung Neoplasms	22672859	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Four up-regulated microRNAs (miR-210, miR-21, miR-31 and miR-182) and two down-regulated mcroiRNAs (miR-126 and miR-145) were consistently reported both in squamous carcinoma and adenocarcinoma-based subgroup analysis
tissue_expression_up	hsa-mir-182	Lung Neoplasms	29516903	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs
tissue_expression_up	hsa-mir-182	Lung Neoplasms	20418022	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	This set includes hsa-miR-182, which was most strongly over-expressed in the lung primary tumors, and hsa-miR-126, which was over-expressed in the metastatic tumors.
tissue_expression_up	hsa-mir-183	Lung Neoplasms	17028596	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);
tissue_expression_up	hsa-mir-183	Lung Neoplasms	29516903	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs
tissue_expression_up	hsa-mir-184	Lung Neoplasms	26199015	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miRNA-197 and miRNA-184 are overexpressed in EGFR-mutant patients with BM and they might be a new biomarker for stratifying the risk of BM in this  subpopulation.
tissue_expression_up	hsa-mir-18a	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_up	hsa-mir-191	Lung Neoplasms	16461460	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	overexpressed
tissue_expression_up	hsa-mir-191	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulation
tissue_expression_up	hsa-mir-192	Lung Neoplasms	26351877	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Collectively, our findings suggested that curcumin inhibited cell proliferation and induced apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of the PI3K/Akt signaling pathway.
tissue_expression_up	hsa-mir-197	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulation
tissue_expression_up	hsa-mir-199a-1	Lung Neoplasms	16461460	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	overexpressed
tissue_expression_up	hsa-mir-200b	Lung Neoplasms	29516903	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs
tissue_expression_up	hsa-mir-203	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulation
tissue_expression_up	hsa-mir-205	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulation
tissue_expression_up	hsa-mir-205	Lung Neoplasms	29516903	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs
tissue_expression_up	hsa-mir-20a	Lung Neoplasms	19597473	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-17-92 overexpression may serve as a fine-tuning influence to counterbalance the generation of DNA damage
tissue_expression_up	hsa-mir-20a	Lung Neoplasms	26560875	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	increased expression of miR-20 in lung cancer
tissue_expression_up	hsa-mir-21	Lung Neoplasms	16461460	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	overexpressed
tissue_expression_up	hsa-mir-21	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulation
tissue_expression_up	hsa-mir-21	Lung Neoplasms	20363096	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulated; Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis
tissue_expression_up	hsa-mir-21	Lung Neoplasms	22492962	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	The levels of miR-10b and miR-21 are found significantly increased in the CSF (cerebrospinal fluid) of patients with glioblastoma and brain metastasis of breast and lung cancer, compared with tumors in remission and a variety of nonneoplastic conditions.
tissue_expression_up	hsa-mir-21	Lung Neoplasms	22638884	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control (P < 0.001), and its sensitivity and specificity were significantly higher than the currently used tumor markers.
tissue_expression_up	hsa-mir-21	Lung Neoplasms	19748927	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-21, mir-31, miR-130a, miR-146b and miR-377 were consistently upregulated, whereas miR-1 and miR-143 were downregulated in lung tumors relative to normal lungs.
tissue_expression_up	hsa-mir-21	Lung Neoplasms	22672859	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Four up-regulated microRNAs (miR-210, miR-21, miR-31 and miR-182) and two down-regulated mcroiRNAs (miR-126 and miR-145) were consistently reported both in squamous carcinoma and adenocarcinoma-based subgroup analysis
tissue_expression_up	hsa-mir-21	Lung Neoplasms	29516903	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs
tissue_expression_up	hsa-mir-21	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_up	hsa-mir-210	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulation
tissue_expression_up	hsa-mir-210	Lung Neoplasms	21965273	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1{alpha}
tissue_expression_up	hsa-mir-210	Lung Neoplasms	22672859	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Four up-regulated microRNAs (miR-210, miR-21, miR-31 and miR-182) and two down-regulated mcroiRNAs (miR-126 and miR-145) were consistently reported both in squamous carcinoma and adenocarcinoma-based subgroup analysis
tissue_expression_up	hsa-mir-210	Lung Neoplasms	29516903	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs
tissue_expression_up	hsa-mir-212	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulation
tissue_expression_up	hsa-mir-214	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulation
tissue_expression_up	hsa-mir-22	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_up	hsa-mir-24-1	Lung Neoplasms	21563230	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. 
tissue_expression_up	hsa-mir-24-2	Lung Neoplasms	16530703	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulation
tissue_expression_up	hsa-mir-29a	Lung Neoplasms	19818597	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	MiRNA expression profiling of human NSCLC cell lines indicated that miR-29a levels were reduced in more invasive cell lines. Exogenous overexpression of miR-29a in both lung and pancreatic cancer cell lines resulted in a significant reduction in the invasion phenotype, as well as in proliferation.
tissue_expression_up	hsa-mir-301a	Lung Neoplasms	20624269	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-301:we found significant overexpression of miR-103, miR-107, miR-301 and miR-338 in lung cancer cells as compared to HBECs
tissue_expression_up	hsa-mir-31	Lung Neoplasms	20237410	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	We found that miR-136, miR-376a, and miR-31 were each prominently overexpressed in murine lung cancers.
tissue_expression_up	hsa-mir-31	Lung Neoplasms	19748927	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-21, mir-31, miR-130a, miR-146b and miR-377 were consistently upregulated, whereas miR-1 and miR-143 were downregulated in lung tumors relative to normal lungs.
tissue_expression_up	hsa-mir-31	Lung Neoplasms	22672859	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Four up-regulated microRNAs (miR-210, miR-21, miR-31 and miR-182) and two down-regulated mcroiRNAs (miR-126 and miR-145) were consistently reported both in squamous carcinoma and adenocarcinoma-based subgroup analysis
tissue_expression_up	hsa-mir-31	Lung Neoplasms	29516903	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs
tissue_expression_up	hsa-mir-31	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_up	hsa-mir-32	Lung Neoplasms	26036635	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Tanshinones suppress AURKA through up-regulation of miR-32 expression in non-small cell lung cancer.
tissue_expression_up	hsa-mir-331	Lung Neoplasms	21563230	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. 
tissue_expression_up	hsa-mir-338	Lung Neoplasms	20624269	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-338:we found significant overexpression of miR-103, miR-107, miR-301 and miR-338 in lung cancer cells as compared to HBECs
tissue_expression_up	hsa-mir-34a	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_up	hsa-mir-374a	Lung Neoplasms	21563230	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. 
tissue_expression_up	hsa-mir-376a-1	Lung Neoplasms	20237410	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	We found that miR-136, miR-376a, and miR-31 were each prominently overexpressed in murine lung cancers.
tissue_expression_up	hsa-mir-376a-2	Lung Neoplasms	20237410	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	We found that miR-136, miR-376a, and miR-31 were each prominently overexpressed in murine lung cancers.
tissue_expression_up	hsa-mir-377	Lung Neoplasms	19748927	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	miR-21, mir-31, miR-130a, miR-146b and miR-377 were consistently upregulated, whereas miR-1 and miR-143 were downregulated in lung tumors relative to normal lungs.
tissue_expression_up	hsa-mir-412	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_up	hsa-mir-504	Lung Neoplasms	20508945	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold.
tissue_expression_up	hsa-mir-629	Lung Neoplasms	19946373	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	upregulated
tissue_expression_up	hsa-mir-638	Lung Neoplasms	21303527	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	We found the upregulation of microRNA-638 and microRNA-923 in bostrycin-treated lung adenocarcinoma cells
tissue_expression_up	hsa-mir-9	Lung Neoplasms	24019037	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	MiR-9 was up-regulated in non-small cell lung cancer tissues and correlated with adverse clinical features and unfavorable survival, indicating that miR-9 might be involved in non-small lung cancer progression and could serve as a promising biomarker for further risk stratification in the treatment of this cancer.
tissue_expression_up	hsa-mir-96	Lung Neoplasms	21563230	disease of cellular proliferation	DOID:1324	C34.1-.3	D008175		HP:0100526	Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. 
tissue_expression_up	hsa-mir-150	Lupus Nephritis	26961386	urinary system disease	DOID:0080162	M32.14	D008181			Overexpression of miR-150 is observed in renal biopsies from patients with lupus  nephritis
tissue_expression_up	hsa-mir-155	Lymphoma	27473081	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	T-MF showed higher miR17 and miR-18a expression compared to F-MF and TR-MF (p 鈮?0.0387) while miR19b, miR92a, and miR-155 showed increased levels in F-MF and TR-MF with respect to T-MF (p 鈮?0.0360).
tissue_expression_up	hsa-mir-17	Lymphoma	27473081	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	Furthermore, MF patients showed higher miRNA expression compared to controls (p 鈮?0.0223). T-MF showed higher miR17 and miR-18a expression compared to F-MF and TR-MF (p 鈮?0.0387) while miR19b, miR92a, and miR-155 showed increased levels in F-MF and TR-MF with respect to T-MF (p 鈮?0.0360).
tissue_expression_up	hsa-mir-18a	Lymphoma	27473081	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	Furthermore, MF patients showed higher miRNA expression compared to controls (p 鈮?0.0223). T-MF showed higher miR17 and miR-18a expression compared to F-MF and TR-MF (p 鈮?0.0387) while miR19b, miR92a, and miR-155 showed increased levels in F-MF and TR-MF with respect to T-MF (p 鈮?0.0360).
tissue_expression_up	hsa-mir-19b	Lymphoma	27473081	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	Furthermore, MF patients showed higher miRNA expression compared to controls (p 鈮?0.0223). T-MF showed higher miR17 and miR-18a expression compared to F-MF and TR-MF (p 鈮?0.0387) while miR19b, miR92a, and miR-155 showed increased levels in F-MF and TR-MF with respect to T-MF (p 鈮?0.0360).
tissue_expression_up	hsa-mir-23b	Lymphoma	24356489	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	We found that miR-23a & miR-23b were up-regulated in radiation induced thymic lymphoma tissue samples.
tissue_expression_up	hsa-mir-629	Lymphoma	19946373	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	upregulated
tissue_expression_up	hsa-mir-92a	Lymphoma	27473081	disease of cellular proliferation	DOID:0060058	C85.9	D008223		HP:0002665	Furthermore, MF patients showed higher miRNA expression compared to controls (p 鈮?0.0223). T-MF showed higher miR17 and miR-18a expression compared to F-MF and TR-MF (p 鈮?0.0387) while miR19b, miR92a, and miR-155 showed increased levels in F-MF and TR-MF with respect to T-MF (p 鈮?0.0360).
tissue_expression_up	hsa-mir-145	Lymphoma, B-Cell	21803762	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	miR-9 is upregulated.
tissue_expression_up	hsa-mir-155	Lymphoma, B-Cell	21987025	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	Four of miRNAs (miR-15a, miR-16-1, miR-29c, and miR-155) were significantly elevated in DLBCL (diffuse large B cell lymphoma) serum when compared with normal controls (P<0.05), while miR-34a was downregulated in DLBCL serum when compared with controls (P<0.05). Receiver operating characteristic analyses reflects strong discriminating DLBCL from controls, with area under the curves of 0.7722, 0.7002, 0.6672, 0.8538, and 0.7157 for miR-15a, miR-16-1, miR-29c, miR-34a, and miR-155, respectively. At the cut-off value of 0.0006 for miR-15a, the sensitivity was 80% and the specificity was 76%; at the cut-off value of 0.0886 for miR-16-1, the sensitivity was 94% and the specificity was 51%; at the cut-off value of 1.395 for miR-34a, the sensitivity was 100% and the specificity was 70%; at the cut-off value of 0.0022 for miR-155, the sensitivity was 83% and the specificity was 65%.
tissue_expression_up	hsa-mir-15a	Lymphoma, B-Cell	21987025	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	Four of miRNAs (miR-15a, miR-16-1, miR-29c, and miR-155) were significantly elevated in DLBCL (diffuse large B cell lymphoma) serum when compared with normal controls (P<0.05), while miR-34a was downregulated in DLBCL serum when compared with controls (P<0.05). Receiver operating characteristic analyses reflects strong discriminating DLBCL from controls, with area under the curves of 0.7722, 0.7002, 0.6672, 0.8538, and 0.7157 for miR-15a, miR-16-1, miR-29c, miR-34a, and miR-155, respectively. At the cut-off value of 0.0006 for miR-15a, the sensitivity was 80% and the specificity was 76%; at the cut-off value of 0.0886 for miR-16-1, the sensitivity was 94% and the specificity was 51%; at the cut-off value of 1.395 for miR-34a, the sensitivity was 100% and the specificity was 70%; at the cut-off value of 0.0022 for miR-155, the sensitivity was 83% and the specificity was 65%.
tissue_expression_up	hsa-mir-16-1	Lymphoma, B-Cell	21987025	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	Four of miRNAs (miR-15a, miR-16-1, miR-29c, and miR-155) were significantly elevated in DLBCL (diffuse large B cell lymphoma) serum when compared with normal controls (P<0.05), while miR-34a was downregulated in DLBCL serum when compared with controls (P<0.05). Receiver operating characteristic analyses reflects strong discriminating DLBCL from controls, with area under the curves of 0.7722, 0.7002, 0.6672, 0.8538, and 0.7157 for miR-15a, miR-16-1, miR-29c, miR-34a, and miR-155, respectively. At the cut-off value of 0.0006 for miR-15a, the sensitivity was 80% and the specificity was 76%; at the cut-off value of 0.0886 for miR-16-1, the sensitivity was 94% and the specificity was 51%; at the cut-off value of 1.395 for miR-34a, the sensitivity was 100% and the specificity was 70%; at the cut-off value of 0.0022 for miR-155, the sensitivity was 83% and the specificity was 65%.
tissue_expression_up	hsa-mir-17	Lymphoma, B-Cell	15944707	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	overexpressed
tissue_expression_up	hsa-mir-17	Lymphoma, B-Cell	19945163	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	miR-17-5p:the detection of upregulation of miR-17-5p and miR-181a in B- and T-cell lymphomas respectively
tissue_expression_up	hsa-mir-17	Lymphoma, B-Cell	21803762	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	miR-17-5p is upregulated.
tissue_expression_up	hsa-mir-181a-1	Lymphoma, B-Cell	19945163	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	miR-181a:the detection of upregulation of miR-17-5p and miR-181a in B- and T-cell lymphomas respectively
tissue_expression_up	hsa-mir-181a-2	Lymphoma, B-Cell	19945163	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	miR-181a:the detection of upregulation of miR-17-5p and miR-181a in B- and T-cell lymphomas respectively
tissue_expression_up	hsa-mir-18a	Lymphoma, B-Cell	15944707	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	overexpressed
tissue_expression_up	hsa-mir-193b	Lymphoma, B-Cell	21803762	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	miR-9 is upregulated.
tissue_expression_up	hsa-mir-199a-1	Lymphoma, B-Cell	21803762	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	miR-9 is upregulated.
tissue_expression_up	hsa-mir-199a-2	Lymphoma, B-Cell	21803762	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	miR-9 is upregulated.
tissue_expression_up	hsa-mir-19a	Lymphoma, B-Cell	15944707	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	overexpressed
tissue_expression_up	hsa-mir-19b-1	Lymphoma, B-Cell	15944707	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	overexpressed
tissue_expression_up	hsa-mir-19b-2	Lymphoma, B-Cell	15944707	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	overexpressed
tissue_expression_up	hsa-mir-20a	Lymphoma, B-Cell	21803762	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	miR-20a is upregulated.
tissue_expression_up	hsa-mir-214	Lymphoma, B-Cell	21803762	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	miR-9 is upregulated.
tissue_expression_up	hsa-mir-29c	Lymphoma, B-Cell	21987025	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	Four of miRNAs (miR-15a, miR-16-1, miR-29c, and miR-155) were significantly elevated in DLBCL (diffuse large B cell lymphoma) serum when compared with normal controls (P<0.05), while miR-34a was downregulated in DLBCL serum when compared with controls (P<0.05). Receiver operating characteristic analyses reflects strong discriminating DLBCL from controls, with area under the curves of 0.7722, 0.7002, 0.6672, 0.8538, and 0.7157 for miR-15a, miR-16-1, miR-29c, miR-34a, and miR-155, respectively. At the cut-off value of 0.0006 for miR-15a, the sensitivity was 80% and the specificity was 76%; at the cut-off value of 0.0886 for miR-16-1, the sensitivity was 94% and the specificity was 51%; at the cut-off value of 1.395 for miR-34a, the sensitivity was 100% and the specificity was 70%; at the cut-off value of 0.0022 for miR-155, the sensitivity was 83% and the specificity was 65%.
tissue_expression_up	hsa-mir-9-1	Lymphoma, B-Cell	21803762	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	miR-9 is upregulated.
tissue_expression_up	hsa-mir-9-2	Lymphoma, B-Cell	21803762	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	miR-9 is upregulated.
tissue_expression_up	hsa-mir-9-3	Lymphoma, B-Cell	21803762	disease of cellular proliferation	DOID:707		D016393	109565	HP:0012191	miR-9 is upregulated.
tissue_expression_up	hsa-mir-155	Lymphoma, Hodgkin	12661002	disease of cellular proliferation	DOID:8567	C81	D006689	236000	HP:0012189	upregulated
tissue_expression_up	hsa-mir-182	Lymphoma, Hodgkin	22343918	disease of cellular proliferation	DOID:8567	C81	D006689	236000	HP:0012189	In cHL cell lines FOXO1 is inactivated by multiple mechanisms, including constitutive activation of AKT/PKB and MAPK/ERK kinases and up-regulation of microRNAs miR-96, miR-182, and miR-183.
tissue_expression_up	hsa-mir-183	Lymphoma, Hodgkin	22343918	disease of cellular proliferation	DOID:8567	C81	D006689	236000	HP:0012189	In cHL cell lines FOXO1 is inactivated by multiple mechanisms, including constitutive activation of AKT/PKB and MAPK/ERK kinases and up-regulation of microRNAs miR-96, miR-182, and miR-183.
tissue_expression_up	hsa-mir-20a	Lymphoma, Hodgkin	26951445	disease of cellular proliferation	DOID:8567	C81	D006689	236000	HP:0012189	miR-20a-5p were found to be increased in  cHL
tissue_expression_up	hsa-mir-96	Lymphoma, Hodgkin	22343918	disease of cellular proliferation	DOID:8567	C81	D006689	236000	HP:0012189	In cHL cell lines FOXO1 is inactivated by multiple mechanisms, including constitutive activation of AKT/PKB and MAPK/ERK kinases and up-regulation of microRNAs miR-96, miR-182, and miR-183.
tissue_expression_up	hsa-mir-125a	Lymphoma, Large B-Cell, Diffuse	28817403	disease of cellular proliferation	DOID:0050745	C83.3	D016403	109565		PB-DLBCL and DLBCL-GCB-CC also had much higher levels of miR-125a-3p, miR-34-3p, and miR-155-5p, and significantly lower levels of miR-17-5p and miR-17-3p
tissue_expression_up	hsa-mir-126	Lymphoma, Large B-Cell, Diffuse	26683099	disease of cellular proliferation	DOID:0050745	C83.3	D016403	109565		We observed increased expression of proangiomiRs Let-7f, miR-17, miR-18a, miR-19b, miR-126, miR-130a, miR-210, miR-296 and miR-378
tissue_expression_up	hsa-mir-130a	Lymphoma, Large B-Cell, Diffuse	26683099	disease of cellular proliferation	DOID:0050745	C83.3	D016403	109565		We observed increased expression of proangiomiRs Let-7f, miR-17, miR-18a, miR-19b, miR-126, miR-130a, miR-210, miR-296 and miR-378
tissue_expression_up	hsa-mir-155	Lymphoma, Large B-Cell, Diffuse	16041695	disease of cellular proliferation	DOID:0050745	C83.3	D016403	109565		upregulated
tissue_expression_up	hsa-mir-155	Lymphoma, Large B-Cell, Diffuse	19744129	disease of cellular proliferation	DOID:0050745	C83.3	D016403	109565		Their aberrant expression has been associated with solid tumors and hematopoietic malignancies as suggested by the frequent deletion of mir-15a and mir-16-1 in chronic lymphocytic leukemia, the increased levels of mir-155 in diffuse large B-cell lymphomas and the increased levels of mir-181 in acute myeloid leukemia M1 and M2. 
tissue_expression_up	hsa-mir-155	Lymphoma, Large B-Cell, Diffuse	28817403	disease of cellular proliferation	DOID:0050745	C83.3	D016403	109565		PB-DLBCL and DLBCL-GCB-CC also had much higher levels of miR-125a-3p, miR-34-3p, and miR-155-5p, and significantly lower levels of miR-17-5p and miR-17-3p
tissue_expression_up	hsa-mir-296	Lymphoma, Large B-Cell, Diffuse	26683099	disease of cellular proliferation	DOID:0050745	C83.3	D016403	109565		We observed increased expression of proangiomiRs Let-7f, miR-17, miR-18a, miR-19b, miR-126, miR-130a, miR-210, miR-296 and miR-378
tissue_expression_up	hsa-mir-34	Lymphoma, Large B-Cell, Diffuse	28817403	disease of cellular proliferation	DOID:0050745	C83.3	D016403	109565		PB-DLBCL and DLBCL-GCB-CC also had much higher levels of miR-125a-3p, miR-34-3p, and miR-155-5p, and significantly lower levels of miR-17-5p and miR-17-3p
tissue_expression_up	hsa-mir-378	Lymphoma, Large B-Cell, Diffuse	26683099	disease of cellular proliferation	DOID:0050745	C83.3	D016403	109565		We observed increased expression of proangiomiRs Let-7f, miR-17, miR-18a, miR-19b, miR-126, miR-130a, miR-210, miR-296 and miR-378
tissue_expression_up	hsa-mir-15b	Lymphoma, Mantle-Cell	26676972			C83.10	D020522			Our present findings suggest that the upregulated expression of miR-15b is likely to play an important role in the trans-formation of cMCL to aMCL.
tissue_expression_up	hsa-mir-17	Lymphoma, T-Cell	19945163	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	miR-17-5p:the detection of upregulation of miR-17-5p and miR-181a in B- and T-cell lymphomas respectively
tissue_expression_up	hsa-mir-181a-1	Lymphoma, T-Cell	19945163	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	miR-181a:the detection of upregulation of miR-17-5p and miR-181a in B- and T-cell lymphomas respectively
tissue_expression_up	hsa-mir-181a-2	Lymphoma, T-Cell	19945163	disease of cellular proliferation	DOID:0050749	C84.4	D016399	186960	HP:0012190	miR-181a:the detection of upregulation of miR-17-5p and miR-181a in B- and T-cell lymphomas respectively
tissue_expression_up	hsa-mir-15a	Macular Degeneration	24970617	nervous system disease	DOID:4448	H35.30	D008268	PS603075	HP:0000608	The expression of several miRNAs related to angiogenesis and fibrosis was expressed significantly higher in the vitreous of eyes with PDR.Further studies are needed to understand the role played by the miRNAs in the biological function of the eye.
tissue_expression_up	hsa-mir-29a	Macular Degeneration	24970617	nervous system disease	DOID:4448	H35.30	D008268	PS603075	HP:0000608	The expression of several miRNAs related to angiogenesis and fibrosis was expressed significantly higher in the vitreous of eyes with PDR.Further studies are needed to understand the role played by the miRNAs in the biological function of the eye.
tissue_expression_up	hsa-mir-320a	Macular Degeneration	24970617	nervous system disease	DOID:4448	H35.30	D008268	PS603075	HP:0000608	The expression of several miRNAs related to angiogenesis and fibrosis was expressed significantly higher in the vitreous of eyes with PDR.Further studies are needed to understand the role played by the miRNAs in the biological function of the eye.
tissue_expression_up	hsa-mir-320b	Macular Degeneration	24970617	nervous system disease	DOID:4448	H35.30	D008268	PS603075	HP:0000608	The expression of several miRNAs related to angiogenesis and fibrosis was expressed significantly higher in the vitreous of eyes with PDR.Further studies are needed to understand the role played by the miRNAs in the biological function of the eye.
tissue_expression_up	hsa-mir-423	Macular Degeneration	24970617	nervous system disease	DOID:4448	H35.30	D008268	PS603075	HP:0000608	The expression of several miRNAs related to angiogenesis and fibrosis was expressed significantly higher in the vitreous of eyes with PDR.Further studies are needed to understand the role played by the miRNAs in the biological function of the eye.
tissue_expression_up	hsa-mir-93	Macular Degeneration	24970617	nervous system disease	DOID:4448	H35.30	D008268	PS603075	HP:0000608	The expression of several miRNAs related to angiogenesis and fibrosis was expressed significantly higher in the vitreous of eyes with PDR.Further studies are needed to understand the role played by the miRNAs in the biological function of the eye.
tissue_expression_up	hsa-mir-210	Male Infertility	27535712	reproductive system disease	DOID:12336	N46.9	D007248		HP:0003251	 Compared with obstructive azoospermia (OA) as normal control, our results suggest that miR-210  was significantly up-regulated in testis of patients with NOA (P<0.05)
tissue_expression_up	hsa-mir-145	Malignant Neoplasms [unspecific]	25106061			C80.1	D009369			Our findings indicate that high miR-145 expression is better at predicting patient survival rather than disease progression for malignant tumors, especially for SCC and glioblastoma in Asians. Considering the insufficient evidence, further investigations and more studies are needed.
tissue_expression_up	hsa-mir-101	Medulloblastoma	29658967	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma
tissue_expression_up	hsa-mir-106b	Medulloblastoma	25041637	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	These data suggested the upregulation of miR-106b in MB and the involvement of miR-106b in MB biology.
tissue_expression_up	hsa-mir-10b	Medulloblastoma	26394044	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	microRNA-10b Is Overexpressed and Critical for Cell Survival and Proliferation in Medulloblastoma.
tissue_expression_up	hsa-mir-126	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-126 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-127	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-127-3p was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-139	Medulloblastoma	29658967	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma
tissue_expression_up	hsa-mir-143	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-143 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-144	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-144* was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-145	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-145 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-146a	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-146a was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-1827	Medulloblastoma	29658967	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma
tissue_expression_up	hsa-mir-193a	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-193a-5p was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-203	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-203 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-21	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-21* was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-222	Medulloblastoma	29658967	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma
tissue_expression_up	hsa-mir-223	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-223 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-323a	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-323-3p was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-338	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-338-3p was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-34c	Medulloblastoma	29658967	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma
tissue_expression_up	hsa-mir-361	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-361-3p was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-376a-1	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-376 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-376a-2	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-376 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-376c	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-376c was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-379	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-379 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-409	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-409-3p was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-494	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-494 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-495	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-495 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-539	Medulloblastoma	21931624	disease of cellular proliferation	DOID:0050902	C71.6	D008527	155255	HP:0002885	hsa-mir-539 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells).
tissue_expression_up	hsa-mir-106a	Melanoma	21509659	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	significantly up-regulated in uveal melanomas compared with normal uveal tissues
tissue_expression_up	hsa-mir-106a	Melanoma	21763111	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Early steps in skin tumor formation in HPV8-CER mice were associated with an upregulation of the oncogenic miRNA-17-5p, -21 and -106a and a downregulation of the tumor-suppressive miRNA-155 and -206, which could be demonstrated by qPCR and in situ hybridization.
tissue_expression_up	hsa-mir-1225	Melanoma	22898827	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes.
tissue_expression_up	hsa-mir-125b	Melanoma	24635082	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MLK3 is upregulated in metastatic melanoma, and regulates cell proliferation and invasion in melanoma cells. MLK3 is a direct target of miR-125b.
tissue_expression_up	hsa-mir-125b	Melanoma	26684239	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-34a, miR-100 and miR-125b showed high expression in both resistant cells and in tumor biopsies
tissue_expression_up	hsa-mir-1260	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_up	hsa-mir-1274a	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_up	hsa-mir-1274b	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_up	hsa-mir-130b	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_up	hsa-mir-146a	Melanoma	19578755	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	overexpressed
tissue_expression_up	hsa-mir-146a	Melanoma	20442294	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-146a:miR-146a and miR-155 were upregulated in all analyzed patients but none of the cell lines
tissue_expression_up	hsa-mir-146a	Melanoma	23441115	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MiR-146a and miR-26a were overexpressed more than threefold in VH from patients with uveal melanomas compared to the other pathological groups (Wilcoxon signed-rank test, p value <0.05).
tissue_expression_up	hsa-mir-146b	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_up	hsa-mir-155	Melanoma	20442294	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-155:miR-146a and miR-155 were upregulated in all analyzed patients but none of the cell lines
tissue_expression_up	hsa-mir-155	Melanoma	21863027	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	PCR analysis revealed primary cutaneous melanomas had an 8.6-fold overexpression of miR-21 and a 7.5-fold overexpression of miR-155 compared with benign naevi (P<0.0001).
tissue_expression_up	hsa-mir-155	Melanoma	27469124	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	A comparison of Spitzoid melanomas to benign nevi revealed overexpression of miR-21, miR-150, and miR-155 in the malignant primaries (p < 0.05).
tissue_expression_up	hsa-mir-15b	Melanoma	19830692	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MiR-15b:MiR-15b and miR-210 were significantly upregulated, miR-34a was significantly downregulated in melanomas
tissue_expression_up	hsa-mir-17	Melanoma	19578755	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-17-5p; overexpressed
tissue_expression_up	hsa-mir-17	Melanoma	21509659	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	significantly up-regulated in uveal melanomas compared with normal uveal tissues
tissue_expression_up	hsa-mir-17	Melanoma	21763111	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Early steps in skin tumor formation in HPV8-CER mice were associated with an upregulation of the oncogenic miRNA-17-5p, -21 and -106a and a downregulation of the tumor-suppressive miRNA-155 and -206, which could be demonstrated by qPCR and in situ hybridization.
tissue_expression_up	hsa-mir-17	Melanoma	24462553	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	We show that miRNAs of the miR-17-92 cluster (miR-20a2, miR-92a1, miR-17 and miR-18a), miR-126, miR-182, miR-210 and miR-214 are upregulated and their respective target genes (RUNX1, HIF1A, TGFBR2, THBS1 and JAK2) are down-regulated in melanoma.
tissue_expression_up	hsa-mir-18a	Melanoma	19578755	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	overexpressed
tissue_expression_up	hsa-mir-193b	Melanoma	20357817	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Furthermore, low expression of miR-191 and high expression of miR-193b were associated with poor melanoma-specific survive
tissue_expression_up	hsa-mir-197	Melanoma	22898827	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes.
tissue_expression_up	hsa-mir-200a	Melanoma	27054085	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Among the up-regulated miRNAs, miR-21, miR-200a and miR-141, are well known to be involved in carcinogenesis.
tissue_expression_up	hsa-mir-20a	Melanoma	19578755	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	overexpressed
tissue_expression_up	hsa-mir-20a	Melanoma	21509659	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	significantly up-regulated in uveal melanomas compared with normal uveal tissues
tissue_expression_up	hsa-mir-21	Melanoma	21509659	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	significantly up-regulated in uveal melanomas compared with normal uveal tissues
tissue_expression_up	hsa-mir-21	Melanoma	21863027	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	PCR analysis revealed primary cutaneous melanomas had an 8.6-fold overexpression of miR-21 and a 7.5-fold overexpression of miR-155 compared with benign naevi (P<0.0001).
tissue_expression_up	hsa-mir-21	Melanoma	22716245	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	microRNA-21 is upregulated in malignant melanoma and influences apoptosis of melanocytic cells.
tissue_expression_up	hsa-mir-21	Melanoma	21763111	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Early steps in skin tumor formation in HPV8-CER mice were associated with an upregulation of the oncogenic miRNA-17-5p, -21 and -106a and a downregulation of the tumor-suppressive miRNA-155 and -206, which could be demonstrated by qPCR and in situ hybridization.
tissue_expression_up	hsa-mir-210	Melanoma	19830692	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-210:MiR-15b and miR-210 were significantly upregulated, miR-34a was significantly downregulated in melanomas
tissue_expression_up	hsa-mir-210	Melanoma	27009863	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Hypoxia-induced gene signatures and overexpression of the hypoxia-regulated miRNA hsa-miR-210 characterized CDXs.
tissue_expression_up	hsa-mir-214	Melanoma	24462553	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	We show that miRNAs of the miR-17-92 cluster (miR-20a2, miR-92a1, miR-17 and miR-18a), miR-126, miR-182, miR-210 and miR-214 are upregulated and their respective target genes (RUNX1, HIF1A, TGFBR2, THBS1 and JAK2) are down-regulated in melanoma.
tissue_expression_up	hsa-mir-22	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_up	hsa-mir-221	Melanoma	21711453	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MicroRNAs-221 and -222 are highly upregulated in several solid tumors, including melanomas.
tissue_expression_up	hsa-mir-222	Melanoma	21711453	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MicroRNAs-221 and -222 are highly upregulated in several solid tumors, including melanomas.
tissue_expression_up	hsa-mir-223	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_up	hsa-mir-26a	Melanoma	23441115	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MiR-146a and miR-26a were overexpressed more than threefold in VH from patients with uveal melanomas compared to the other pathological groups (Wilcoxon signed-rank test, p value <0.05).
tissue_expression_up	hsa-mir-301a	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_up	hsa-mir-328	Melanoma	22898827	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes.
tissue_expression_up	hsa-mir-34a	Melanoma	21509659	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	significantly up-regulated in uveal melanomas compared with normal uveal tissues
tissue_expression_up	hsa-mir-34a	Melanoma	25982144	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	Real-time PCR analysis showed 14-fold increase of miR-34a expression in the SDT group compared to the control group
tissue_expression_up	hsa-mir-3663	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_up	hsa-mir-4281	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_up	hsa-mir-4286	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_up	hsa-mir-484	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_up	hsa-mir-506	Melanoma	21860416	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf.
tissue_expression_up	hsa-mir-507	Melanoma	21860416	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf.
tissue_expression_up	hsa-mir-508	Melanoma	21860416	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf.
tissue_expression_up	hsa-mir-509-1	Melanoma	21860416	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf.
tissue_expression_up	hsa-mir-509-2	Melanoma	21860416	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf.
tissue_expression_up	hsa-mir-509-3	Melanoma	21860416	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf.
tissue_expression_up	hsa-mir-510	Melanoma	21860416	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf.
tissue_expression_up	hsa-mir-513a-1	Melanoma	21860416	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf.
tissue_expression_up	hsa-mir-513a-2	Melanoma	21860416	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf.
tissue_expression_up	hsa-mir-513b	Melanoma	21860416	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf.
tissue_expression_up	hsa-mir-513c	Melanoma	21860416	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf.
tissue_expression_up	hsa-mir-514a-1	Melanoma	21860416	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf.
tissue_expression_up	hsa-mir-514a-2	Melanoma	21860416	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf.
tissue_expression_up	hsa-mir-514a-3	Melanoma	21860416	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf.
tissue_expression_up	hsa-mir-574	Melanoma	22898827	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes.
tissue_expression_up	hsa-mir-634	Melanoma	22898827	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes.
tissue_expression_up	hsa-mir-663	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_up	hsa-mir-720	Melanoma	23111773	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
tissue_expression_up	hsa-mir-766	Melanoma	22898827	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes.
tissue_expression_up	hsa-mir-9-1	Melanoma	22131135	disease of cellular proliferation	DOID:1909	C43.9	D008545	155601	HP:0002861	MicroRNA-9 up-regulates E-cadherin through inhibition of NF-kB1-Snail1 pathway in melanoma.
tissue_expression_up	hsa-mir-190a	Meningioma	22674195	disease of cellular proliferation	DOID:3565	D32.9	D008579	607174	HP:0002858	Downregulation of miR-29c-3p and miR-219-5p were found to be associated with advanced clinical stages of meningioma. Kaplan-Meier analysis showed that high expression of miR-190a and low expression of miR-29c-3p and miR-219-5p correlated significantly with higher recurrence rates in meningioma patients.
tissue_expression_up	hsa-mir-125b	Mesial Temporal Lobe Epilepsy	25801837			G40.209	D004833	608096		In TLE patients, miR-183, miR- 135a, miR-125b, miR-30c and miR-27a were upregulated, whereas miR-128 was downregulated.
tissue_expression_up	hsa-mir-183	Mesial Temporal Lobe Epilepsy	25801837			G40.209	D004833	608096		In TLE patients, miR-183, miR- 135a, miR-125b, miR-30c and miR-27a were upregulated, whereas miR-128 was downregulated.
tissue_expression_up	hsa-mir-106a	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated
tissue_expression_up	hsa-mir-106b	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated
tissue_expression_up	hsa-mir-17	Mesothelioma	21317924	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	Hsa-miR-17* was significantly upregulated and hsa-miR-30c was significantly downregulated by Onconase treatment in all cell lines
tissue_expression_up	hsa-mir-17	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated
tissue_expression_up	hsa-mir-18a	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated
tissue_expression_up	hsa-mir-193a	Mesothelioma	20864637	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	miR-193-3p:Hsa-miR-193-3p was overexpressed in MPM, while hsa-miR-200c and hsa-miR-192 were overexpressed in peripheral lung adenocarcinoma and carcinomas
tissue_expression_up	hsa-mir-19b-1	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated
tissue_expression_up	hsa-mir-19b-2	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated
tissue_expression_up	hsa-mir-20a	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated
tissue_expression_up	hsa-mir-20b	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated
tissue_expression_up	hsa-mir-25	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated
tissue_expression_up	hsa-mir-92a-1	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated
tissue_expression_up	hsa-mir-92a-2	Mesothelioma	21358347	disease of cellular proliferation	DOID:1790	C45.9	C562839	156240	HP:0100001	miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated
tissue_expression_up	hsa-mir-26a-1	Multiple Endocrine Neoplasia Type 1	22409234	genetic disease	DOID:10017	E31.21	D018761	PS131100		The authors found that in hADSCs the siRNA-induced silencing of MEN1 mRNA resulted in a down regulation of miR-26a, with a consequent up-regulation of SMAD1 protein.
tissue_expression_up	hsa-mir-26a-2	Multiple Endocrine Neoplasia Type 1	22409234	genetic disease	DOID:10017	E31.21	D018761	PS131100		The authors found that in hADSCs the siRNA-induced silencing of MEN1 mRNA resulted in a down regulation of miR-26a, with a consequent up-regulation of SMAD1 protein.
tissue_expression_up	hsa-mir-21	Multiple Myeloma	22739167	disease of cellular proliferation	DOID:9538		D009101	254500	HP:0006775	It is concluded that the expression levels of miR-21 in BMMNC of MM patients are significantly higher than in normal bone marrow, these data indicated that miR-21 may play an important role in the development of MM.
tissue_expression_up	hsa-mir-21	Multiple Myeloma	25704079	disease of cellular proliferation	DOID:9538		D009101	254500	HP:0006775	EBV could further exacerbate the disease by inducing miR-21
tissue_expression_up	hsa-mir-128-1	Multiple Sclerosis	22088562	nervous system disease	DOID:2377	G35	D009103	PS126200		miR-128 and miR-27b were increased in naive and miR-340 in memory CD4(+) T cells from patients with multiple sclerosis, inhibiting Th2 cell development and favouring pro-inflammatory Th1 responses.
tissue_expression_up	hsa-mir-128-2	Multiple Sclerosis	22088562	nervous system disease	DOID:2377	G35	D009103	PS126200		miR-128 and miR-27b were increased in naive and miR-340 in memory CD4(+) T cells from patients with multiple sclerosis, inhibiting Th2 cell development and favouring pro-inflammatory Th1 responses.
tissue_expression_up	hsa-mir-155	Multiple Sclerosis	21453702	nervous system disease	DOID:2377	G35	D009103	PS126200		Several miRNAs such as miR-155 or miR-326 are considerably overexpressed in active MS lesions versus controls
tissue_expression_up	hsa-mir-155	Multiple Sclerosis	27310932	nervous system disease	DOID:2377	G35	D009103	PS126200		up-regulation of miR-155 (p value = 0.009) and miR-132 (p value = 0.04) in MS patients
tissue_expression_up	hsa-mir-27b	Multiple Sclerosis	22088562	nervous system disease	DOID:2377	G35	D009103	PS126200		miR-128 and miR-27b were increased in naive and miR-340 in memory CD4(+) T cells from patients with multiple sclerosis, inhibiting Th2 cell development and favouring pro-inflammatory Th1 responses.
tissue_expression_up	hsa-mir-326	Multiple Sclerosis	21453702	nervous system disease	DOID:2377	G35	D009103	PS126200		Several miRNAs such as miR-155 or miR-326 are considerably overexpressed in active MS lesions versus controls
tissue_expression_up	hsa-mir-326	Multiple Sclerosis	24936144	nervous system disease	DOID:2377	G35	D009103	PS126200		For instance, miR-21, miR-142-3p, miR-146a, miR-146b, miR-155 and miR-326 were up-regulated in both peripheral blood mononuclear cells (PBMCs) and brain white matter lesions from MS patients and mouse model as well.
tissue_expression_up	hsa-mir-23a	Muscle Atrophy	28000445			M62.5	D009133		HP:0100295	Delphinidin Prevents Muscle Atrophy and Upregulates miR-23a Expression.
tissue_expression_up	hsa-mir-100	Muscular Dystrophy	21840938			G71.0	D009136	310200	HP:0003560	highly expressed in fetal muscle.
tissue_expression_up	hsa-mir-127	Muscular Dystrophy	21840938			G71.0	D009136	310200	HP:0003560	miR-127-3p: highly expressed in fetal muscle.
tissue_expression_up	hsa-mir-136	Muscular Dystrophy	21840938			G71.0	D009136	310200	HP:0003560	miR-136*: highly expressed in fetal muscle.
tissue_expression_up	hsa-mir-148a	Muscular Dystrophy	21840938			G71.0	D009136	310200	HP:0003560	highly expressed in fetal muscle.
tissue_expression_up	hsa-mir-155	Muscular Dystrophy	26398013			G71.0	D009136	310200	HP:0003560	Up-regulation of immune-related miRNAs in muscle, for example, miR-155 and miR-146, is associated with autoimmunity
tissue_expression_up	hsa-mir-192	Muscular Dystrophy	21840938			G71.0	D009136	310200	HP:0003560	highly expressed in fetal muscle.
tissue_expression_up	hsa-mir-206	Muscular Dystrophy	22129894			G71.0	D009136	310200	HP:0003560	The expression of miR-206 is increased in muscular dystrophy.
tissue_expression_up	hsa-mir-335	Muscular Dystrophy	21840938			G71.0	D009136	310200	HP:0003560	highly expressed in fetal muscle.
tissue_expression_up	hsa-mir-376c	Muscular Dystrophy	21840938			G71.0	D009136	310200	HP:0003560	highly expressed in fetal muscle.
tissue_expression_up	hsa-mir-489	Muscular Dystrophy	21840938			G71.0	D009136	310200	HP:0003560	highly expressed in fetal muscle.
tissue_expression_up	hsa-mir-502	Muscular Dystrophy	21840938			G71.0	D009136	310200	HP:0003560	miR-502-3p: highly expressed in fetal muscle.
tissue_expression_up	hsa-mir-32	Muscular Dystrophy, Facioscapulohumeral	24145033	musculoskeletal system disease	DOID:11727	G71.0	D020391	158900		Twenty-one microRNAs (miR-1, miR-7, miR-15a, miR-22, miR-30e, miR-32, miR-107, miR-133a, miR-133b, miR-139, miR-152, miR-206, miR-223, miR-302b, miR-331, miR-362, miR-365, miR-382, miR-496, miR-532, miR-654, and miR-660) were up-regulated
tissue_expression_up	hsa-mir-155	Mycosis Fungoides	21406335			C84.00	D009182			upregulated in tumor stage MF compared to benign inflammatory dermatoses.
tissue_expression_up	hsa-mir-155	Mycosis Fungoides	21966986			C84.00	D009182			MiR-155 was only found to be slightly overexpressed in MF compared to healthy controls. Furthermore, metastatic MF demonstrated lower concentrations of let-7a, let-7d and let-7f when compared to MF limited to the skin.
tissue_expression_up	hsa-mir-92a-1	Mycosis Fungoides	21406335			C84.00	D009182			upregulated in tumor stage MF compared to benign inflammatory dermatoses.
tissue_expression_up	hsa-mir-92a-2	Mycosis Fungoides	21406335			C84.00	D009182			upregulated in tumor stage MF compared to benign inflammatory dermatoses.
tissue_expression_up	hsa-mir-93	Mycosis Fungoides	21406335			C84.00	D009182			upregulated in tumor stage MF compared to benign inflammatory dermatoses.
tissue_expression_up	hsa-mir-1-1	Myelodysplastic Syndromes	20627384	disease of cellular proliferation	DOID:0050908	D46.9	D009190	614286	HP:0002863	miR-1:Evaluation in a larger cohort could confirm the up-regulation of the miR-1 in MDS
tissue_expression_up	hsa-mir-1-2	Myelodysplastic Syndromes	20627384	disease of cellular proliferation	DOID:0050908	D46.9	D009190	614286	HP:0002863	miR-1:Evaluation in a larger cohort could confirm the up-regulation of the miR-1 in MDS
tissue_expression_up	hsa-mir-34a	Myelodysplastic Syndromes	21150891	disease of cellular proliferation	DOID:0050908	D46.9	D009190	614286	HP:0002863	In early MDS, we monitored upregulation of proapoptotic miR-34a
tissue_expression_up	hsa-mir-146b	Myeloproliferative Neoplasms	26116595	disease of cellular proliferation	DOID:2226	D47.1		616871		Up-regulation of MicroRNA 146b is Associated with Myelofibrosis in Myeloproliferative Neoplasms.
tissue_expression_up	hsa-mir-1	Myocardial Infarction	24046434	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	Consistent with previous publications, cardiac specific miR-1 and miR-133a were up-regulated in STEMI patients compared with healthy controls (both, P < 0.0001)
tissue_expression_up	hsa-mir-1-1	Myocardial Infarction	22330002	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	MiR-1, -21 -133a and -423-5p showed a 3- to 10-fold increase and miR-499-5p exhibited >80-fold increase in acute NSTEMI patient vs. CTR.
tissue_expression_up	hsa-mir-1-2	Myocardial Infarction	22330002	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	MiR-1, -21 -133a and -423-5p showed a 3- to 10-fold increase and miR-499-5p exhibited >80-fold increase in acute NSTEMI patient vs. CTR.
tissue_expression_up	hsa-mir-133a-1	Myocardial Infarction	22330002	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	MiR-1, -21 -133a and -423-5p showed a 3- to 10-fold increase and miR-499-5p exhibited >80-fold increase in acute NSTEMI patient vs. CTR.
tissue_expression_up	hsa-mir-133a-2	Myocardial Infarction	22330002	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	MiR-1, -21 -133a and -423-5p showed a 3- to 10-fold increase and miR-499-5p exhibited >80-fold increase in acute NSTEMI patient vs. CTR.
tissue_expression_up	hsa-mir-143	Myocardial Infarction	29162889	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly
tissue_expression_up	hsa-mir-155	Myocardial Infarction	19581315	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	Overexpressed; arrhythmogenic miR-1, contributing to ischaemic arrhythmogenesis stimulated by beta-adrenergic pathway; downregulatied by propranolol together with SRF
tissue_expression_up	hsa-mir-155	Myocardial Infarction	29642385	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	Exposure to the high dose of CS also significantly upregulated the miRNA-155 level in the aortic tissues of ApoE KO mice
tissue_expression_up	hsa-mir-208a	Myocardial Infarction	27314868	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	over-expression of miR-208a in myocardial infarction tissue
tissue_expression_up	hsa-mir-21	Myocardial Infarction	22330002	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	MiR-1, -21 -133a and -423-5p showed a 3- to 10-fold increase and miR-499-5p exhibited >80-fold increase in acute NSTEMI patient vs. CTR.
tissue_expression_up	hsa-mir-21	Myocardial Infarction	25896982	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	Compared to sham group, we found a twofold increase in the cardiac expression of microRNA-21 and 0.5-fold decrease in microRNA-29b in heart tissue from vehicle-treated MI.
tissue_expression_up	hsa-mir-21	Myocardial Infarction	26253453	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	Compared with the CON group, miR-1 was downregulated, whereas miR-21 was upregulated, and BCL2 messenger RNA (mRNA) was upregulated, whereas BAX mRNA and  programmed cell death 4 mRNA remained unchanged in the IPO group.
tissue_expression_up	hsa-mir-21	Myocardial Infarction	29642385	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	Moreover, the expression level of miR-126 tended to be downregulated and that of miR-21 tended to be upregulated in ApoE KO mice exposed to the high dose of CS, albeit statistically insignificant
tissue_expression_up	hsa-mir-423	Myocardial Infarction	22330002	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	MiR-1, -21 -133a and -423-5p showed a 3- to 10-fold increase and miR-499-5p exhibited >80-fold increase in acute NSTEMI patient vs. CTR.
tissue_expression_up	hsa-mir-92a	Myocardial Infarction	25064220	cardiovascular system disease	DOID:5844	I21	D009203	608557	HP:0001658	miR-92a expression in ischemia-reperfusion group was significantly higher than in sham operation group
tissue_expression_up	hsa-mir-125b-1	Myocardial Ischemic-Reperfusion Injury	23123599				D015428			SR-A deficiency reduces myocardial ischemia/reperfusion injury; involvement of increased microRNA-125b expression in macrophages
tissue_expression_up	hsa-mir-125b-2	Myocardial Ischemic-Reperfusion Injury	23123599				D015428			SR-A deficiency reduces myocardial ischemia/reperfusion injury; involvement of increased microRNA-125b expression in macrophages
tissue_expression_up	hsa-mir-15a	Myocardial Ischemic-Reperfusion Injury	22783320				D015428			MicroRNA-15a/b are up-regulated in response to myocardial ischemia/reperfusion injury.
tissue_expression_up	hsa-mir-15b	Myocardial Ischemic-Reperfusion Injury	22783320				D015428			MicroRNA-15a/b are up-regulated in response to myocardial ischemia/reperfusion injury.
tissue_expression_up	hsa-mir-21	Myocardial Ischemic-Reperfusion Injury	26097555				D015428			this study revealed the mechanism that TMZ up-regulated miR-21 expression, then miR-21 targeted PTEN increasing the PI3K pathway and finally the activation of this pathway counteracted the apoptotic effect of hypoxia/reperfusion.
tissue_expression_up	hsa-mir-1-1	Myotonic Muscular Dystrophy	21169019			G71.11	D009223	160900		We found that miR-1 and miR-335 were up-regulated, whereas miR-29b and c, and miR-33 were down-regulated in DM1 biopsies compared to controls.
tissue_expression_up	hsa-mir-125b-2	Myotonic Muscular Dystrophy	22768114			G71.11	D009223	160900		miR-125b-5p: decreased levels compared to controls
tissue_expression_up	hsa-mir-146b	Myotonic Muscular Dystrophy	22768114			G71.11	D009223	160900		higher levels compared to controls
tissue_expression_up	hsa-mir-206	Myotonic Muscular Dystrophy	20487562			G71.11	D009223	160900		microRNA-206:Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients
tissue_expression_up	hsa-mir-208a	Myotonic Muscular Dystrophy	22768114			G71.11	D009223	160900		miR-146b-5p: higher levels compared to controls
tissue_expression_up	hsa-mir-221	Myotonic Muscular Dystrophy	22768114			G71.11	D009223	160900		higher levels compared to controls
tissue_expression_up	hsa-mir-335	Myotonic Muscular Dystrophy	21169019			G71.11	D009223	160900		We found that miR-1 and miR-335 were up-regulated, whereas miR-29b and c, and miR-33 were down-regulated in DM1 biopsies compared to controls.
tissue_expression_up	hsa-mir-34a	Myotonic Muscular Dystrophy	22768114			G71.11	D009223	160900		miR-34a-5p: higher levels compared to controls
tissue_expression_up	hsa-mir-34b	Myotonic Muscular Dystrophy	22768114			G71.11	D009223	160900		miR-34b-3p: higher levels compared to controls
tissue_expression_up	hsa-mir-34c	Myotonic Muscular Dystrophy	22768114			G71.11	D009223	160900		miR-34c-5p: higher levels compared to controls
tissue_expression_up	hsa-mir-381	Myotonic Muscular Dystrophy	22768114			G71.11	D009223	160900		higher levels compared to controls
tissue_expression_up	hsa-mir-146a	Nasopharyngeal Neoplasms	22843060			C11.9	D009303	607107	HP:0100630	Expression of miRNA-146a in nasopharyngeal carcinoma is upregulated by Epstein-Barr virus latent membrane protein 1.
tissue_expression_up	hsa-mir-18a	Nasopharyngeal Neoplasms	21373758			C11.9	D009303	607107	HP:0100630	overexpressed
tissue_expression_up	hsa-let-7a-1	Neoplasms [unspecific]	20370992			C80.1	D009369			over-expressed
tissue_expression_up	hsa-let-7a-2	Neoplasms [unspecific]	20370992			C80.1	D009369			over-expressed
tissue_expression_up	hsa-let-7a-3	Neoplasms [unspecific]	20370992			C80.1	D009369			over-expressed
tissue_expression_up	hsa-let-7i	Neoplasms [unspecific]	20145181			C80.1	D009369			overexpression
tissue_expression_up	hsa-let-7i	Neoplasms [unspecific]	18187804			C80.1	D009369			Changing the cellular levels of let-7i, mir-16, and mir-21 affected the potencies of a number of the anticancer agents by up to 4-fold.
tissue_expression_up	hsa-mir-106b	Neoplasms [unspecific]	20145181			C80.1	D009369			Upregulation
tissue_expression_up	hsa-mir-10b	Neoplasms [unspecific]	25510966			C80.1	D009369			high-expression of microRNA-10b can predict worse outcomes in some types of cancer and the regular monitoring of miR-10b expression might be useful in the clinical practice.
tissue_expression_up	hsa-mir-142	Neoplasms [unspecific]	20145181			C80.1	D009369			overexpression
tissue_expression_up	hsa-mir-142	Neoplasms [unspecific]	20178649			C80.1	D009369			Most of the differentially expressed miRNAs were downregulated in germinomas, but miR-142-5p and miR-146a were upregulated.
tissue_expression_up	hsa-mir-146a	Neoplasms [unspecific]	20178649			C80.1	D009369			Most of the differentially expressed miRNAs were downregulated in germinomas, but miR-142-5p and miR-146a were upregulated.
tissue_expression_up	hsa-mir-155	Neoplasms [unspecific]	20145181			C80.1	D009369			overexpression
tissue_expression_up	hsa-mir-155	Neoplasms [unspecific]	19652553			C80.1	D009369			overexpression, target MYC antagonist MNT
tissue_expression_up	hsa-mir-155	Neoplasms [unspecific]	26850462			C80.1	D009369			miR-155 is an oncogenic miRNA that is often overexpressed in cancer and is associated with poor prognosis.
tissue_expression_up	hsa-mir-155	Neoplasms [unspecific]	19175697			C80.1	D009369			The expression of a subset of miRs (e.g. miR-21 and miR-155) was found to be consistently up-regulated, whereas another subset of miRs (e.g.miR-143 and miR-145) was consistently down-regulated across different cancer types suggesting their involvement in regulating common cellular processes whose deregulation may lead to tumourigenesis.
tissue_expression_up	hsa-mir-16	Neoplasms [unspecific]	18187804			C80.1	D009369			Changing the cellular levels of let-7i, mir-16, and mir-21 affected the potencies of a number of the anticancer agents by up to 4-fold.
tissue_expression_up	hsa-mir-16-1	Neoplasms [unspecific]	20145181			C80.1	D009369			Upregulation
tissue_expression_up	hsa-mir-16-2	Neoplasms [unspecific]	20145181			C80.1	D009369			Upregulation
tissue_expression_up	hsa-mir-17	Neoplasms [unspecific]	20299512			C80.1	D009369			The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a, and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia.
tissue_expression_up	hsa-mir-182	Neoplasms [unspecific]	26063957			C80.1	D009369			High miR-182 expression is associated with poor OS and DFS/RFS/RFI in some types of cancers, and miR-182 may be a useful prognostic biomarker for predicting cancer prognosis. However, given the current insufficient relevant data, further clinical studies are needed.
tissue_expression_up	hsa-mir-182	Neoplasms [unspecific]	20370992			C80.1	D009369			over-expressed
tissue_expression_up	hsa-mir-183	Neoplasms [unspecific]	19676045			C80.1	D009369			up-regulated
tissue_expression_up	hsa-mir-18a	Neoplasms [unspecific]	20299512			C80.1	D009369			The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a, and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia.
tissue_expression_up	hsa-mir-191	Neoplasms [unspecific]	18375788			C80.1	D009369			increased
tissue_expression_up	hsa-mir-192	Neoplasms [unspecific]	20864637			C80.1	D009369			miR-192:Hsa-miR-193-3p was overexpressed in MPM, while hsa-miR-200c and hsa-miR-192 were overexpressed in peripheral lung adenocarcinoma and carcinomas
tissue_expression_up	hsa-mir-19a	Neoplasms [unspecific]	20299512			C80.1	D009369			The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a, and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia.
tissue_expression_up	hsa-mir-19b-1	Neoplasms [unspecific]	20299512			C80.1	D009369			The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a, and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia.
tissue_expression_up	hsa-mir-205	Neoplasms [unspecific]	26681200			C80.1	D009369			miR-9, mi-R-19a, miR-22 and miR-205 that promote EMT, fibrosis and tumorigenesis  were up-regulated.
tissue_expression_up	hsa-mir-20a	Neoplasms [unspecific]	20145181			C80.1	D009369			Upregulation
tissue_expression_up	hsa-mir-20a	Neoplasms [unspecific]	20299512			C80.1	D009369			The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a, and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia.
tissue_expression_up	hsa-mir-21	Neoplasms [unspecific]	20145181			C80.1	D009369			overexpression
tissue_expression_up	hsa-mir-21	Neoplasms [unspecific]	17028596			C80.1	D009369			mir-21 upregulated in glioblastoma and associated with antiapoptosis upregulated in breast cancer (Iorio et al., 2005), and in a signature for solid cancers (Volinia et al., 2006).
tissue_expression_up	hsa-mir-21	Neoplasms [unspecific]	20370992			C80.1	D009369			over-expressed
tissue_expression_up	hsa-mir-21	Neoplasms [unspecific]	26032086			C80.1	D009369			miR-21, miR-148a, miR-505, and miR-1207-5p were found to be upregulated in growth factors-induced EMT process
tissue_expression_up	hsa-mir-21	Neoplasms [unspecific]	18187804			C80.1	D009369			Changing the cellular levels of let-7i, mir-16, and mir-21 affected the potencies of a number of the anticancer agents by up to 4-fold.
tissue_expression_up	hsa-mir-21	Neoplasms [unspecific]	19175697			C80.1	D009369			The expression of a subset of miRs (e.g. miR-21 and miR-155) was found to be consistently up-regulated, whereas another subset of miRs (e.g.miR-143 and miR-145) was consistently down-regulated across different cancer types suggesting their involvement in regulating common cellular processes whose deregulation may lead to tumourigenesis.
tissue_expression_up	hsa-mir-210	Neoplasms [unspecific]	26239498			C80.1	D009369			MicroRNA-210 is upregulated by hypoxia-inducible factor-1α in the stromal cells of giant cell tumors of bone.
tissue_expression_up	hsa-mir-210	Neoplasms [unspecific]	19141645			C80.1	D009369			two miRs, miR-210 and miR-373, are up-regulated in a hypoxia-inducible factor-1alpha-dependent manner in hypoxic cells
tissue_expression_up	hsa-mir-221	Neoplasms [unspecific]	18413744			C80.1	D009369			Thus, the physiologic up-regulation of miR-221 and miR-222 is tightly linked to a cell cycle checkpoint that ensures cell survival by coordinating competency for initiation of S phase with growth factor signaling pathways that stimulate cell proliferation.
tissue_expression_up	hsa-mir-222	Neoplasms [unspecific]	18413744			C80.1	D009369			Thus, the physiologic up-regulation of miR-221 and miR-222 is tightly linked to a cell cycle checkpoint that ensures cell survival by coordinating competency for initiation of S phase with growth factor signaling pathways that stimulate cell proliferation.
tissue_expression_up	hsa-mir-29a	Neoplasms [unspecific]	24210072			C80.1	D009369			MicroRNA-29a upregulates MMP2 in oral squamous cell carcinoma to promote cancer invasion and anti-apoptosis.
tissue_expression_up	hsa-mir-302a	Neoplasms [unspecific]	20332240			C80.1	D009369			overexpressed
tissue_expression_up	hsa-mir-302b	Neoplasms [unspecific]	20332240			C80.1	D009369			overexpressed
tissue_expression_up	hsa-mir-302c	Neoplasms [unspecific]	20332240			C80.1	D009369			overexpressed
tissue_expression_up	hsa-mir-302d	Neoplasms [unspecific]	20332240			C80.1	D009369			overexpressed
tissue_expression_up	hsa-mir-302e	Neoplasms [unspecific]	20332240			C80.1	D009369			overexpressed
tissue_expression_up	hsa-mir-302f	Neoplasms [unspecific]	20332240			C80.1	D009369			overexpressed
tissue_expression_up	hsa-mir-34	Neoplasms [unspecific]	26177460			C80.1	D009369			miR-34a overexpression leads to variable effects on p53 levels in p53-sufficient human cancer cell lines.
tissue_expression_up	hsa-mir-34a	Neoplasms [unspecific]	26177460			C80.1	D009369			miR-34a overexpression leads to variable effects on p53 levels in p53-sufficient human cancer cell lines.
tissue_expression_up	hsa-mir-371a	Neoplasms [unspecific]	20332240			C80.1	D009369			overexpressed
tissue_expression_up	hsa-mir-372	Neoplasms [unspecific]	20332240			C80.1	D009369			overexpressed
tissue_expression_up	hsa-mir-373	Neoplasms [unspecific]	20332240			C80.1	D009369			overexpressed
tissue_expression_up	hsa-mir-373	Neoplasms [unspecific]	19141645			C80.1	D009369			two miRs, miR-210 and miR-373, are up-regulated in a hypoxia-inducible factor-1alpha-dependent manner in hypoxic cells
tissue_expression_up	hsa-mir-381	Neoplasms [unspecific]	26688820			C80.1	D009369			Further study revealed that IκBα was a target gene of miR-381. The upregulation of miR-381 under LPS stimulation contributes to respiratory infections mainly by targeting IκBα.
tissue_expression_up	hsa-mir-423	Neoplasms [unspecific]	20145181			C80.1	D009369			Upregulation
tissue_expression_up	hsa-mir-525	Neoplasms [unspecific]	24147004			C80.1	D009369			The transient up-regulation of miR-525-3p, and the resultant repression of its direct targets ARRB1, TXN1 and HSPA9, is required for cell survival following irradiation. The conserved function of miR-525-3p across several cell types makes this microRNA pathway a promising target for modifying the efficacy of radiotherapy.
tissue_expression_up	hsa-mir-9	Neoplasms [unspecific]	27284255			C80.1	D009369			higher expression level of miR-9 significantly predicted worse  OS in various carcinomas
tissue_expression_up	hsa-mir-92a-1	Neoplasms [unspecific]	20299512			C80.1	D009369			The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a, and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia.
tissue_expression_up	hsa-mir-96	Neoplasms [unspecific]	19676045			C80.1	D009369			up-regulated
tissue_expression_up	hsa-mir-141	Nephrosclerosis	19910931	cardiovascular system disease	DOID:11664	N26.9	D009400		HP:0009741	significantly higher in patients with hypertensive nephrosclerosis than controls
tissue_expression_up	hsa-mir-192	Nephrosclerosis	19910931	cardiovascular system disease	DOID:11664	N26.9	D009400		HP:0009741	significantly higher in patients with hypertensive nephrosclerosis than controls
tissue_expression_up	hsa-mir-200a	Nephrosclerosis	19910931	cardiovascular system disease	DOID:11664	N26.9	D009400		HP:0009741	significantly higher in patients with hypertensive nephrosclerosis than controls
tissue_expression_up	hsa-mir-200b	Nephrosclerosis	19910931	cardiovascular system disease	DOID:11664	N26.9	D009400		HP:0009741	significantly higher in patients with hypertensive nephrosclerosis than controls
tissue_expression_up	hsa-mir-205	Nephrosclerosis	19910931	cardiovascular system disease	DOID:11664	N26.9	D009400		HP:0009741	significantly higher in patients with hypertensive nephrosclerosis than controls
tissue_expression_up	hsa-mir-429	Nephrosclerosis	19910931	cardiovascular system disease	DOID:11664	N26.9	D009400		HP:0009741	significantly higher in patients with hypertensive nephrosclerosis than controls
tissue_expression_up	hsa-mir-193a	Nephrotic Syndrome	28299339	urinary system disease	DOID:1184	N04	D009404	PS256300	HP:0000100	The miR-193a expression levels only slightly increased in NS patients
tissue_expression_up	hsa-mir-7-1	Neurilemmoma	21156648	disease of cellular proliferation	DOID:3192	D36.10	D009442			miRNA-7 attenuation in schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways.
tissue_expression_up	hsa-mir-7-2	Neurilemmoma	21156648	disease of cellular proliferation	DOID:3192	D36.10	D009442			miRNA-7 attenuation in schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways.
tissue_expression_up	hsa-mir-7-3	Neurilemmoma	21156648	disease of cellular proliferation	DOID:3192	D36.10	D009442			miRNA-7 attenuation in schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways.
tissue_expression_up	hsa-mir-1246	Neuroblastoma	24739954	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Parallel mRNA and microRNA profiling of HEV71-infected human neuroblastoma cells  reveal the up-regulation of miR-1246 in association with DLG3 repression.
tissue_expression_up	hsa-mir-34a	Neuroblastoma	22498172	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)
tissue_expression_up	hsa-mir-34a	Neuroblastoma	17888029	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	All of the Fe-NTA-induced rat renal carcinomas and an array of human cancers (151 positive cases of 177) showed high expression of miRNA-34a.
tissue_expression_up	hsa-mir-7-1	Neuroblastoma	22498172	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)
tissue_expression_up	hsa-mir-99a	Neuroblastoma	22498172	disease of cellular proliferation	DOID:769	C74.90	D009447	256700	HP:0003006	Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)
tissue_expression_up	hsa-mir-196a	Niemann-Pick Disease, Type C	21075073	disease of metabolism	DOID:0070113	E75.2	D052556	257220		We found that three miRNAs, miR-196a, miR-196b and miR-296 were up-regulated (>3.5-fold increase, p<0.05) whereas 38 miRNAs were significantly down-regulated in NPC cells (>3.5-fold decrease, p<0.05).
tissue_expression_up	hsa-mir-196b	Niemann-Pick Disease, Type C	21075073	disease of metabolism	DOID:0070113	E75.2	D052556	257220		We found that three miRNAs, miR-196a, miR-196b and miR-296 were up-regulated (>3.5-fold increase, p<0.05) whereas 38 miRNAs were significantly down-regulated in NPC cells (>3.5-fold decrease, p<0.05).
tissue_expression_up	hsa-mir-296	Niemann-Pick Disease, Type C	21075073	disease of metabolism	DOID:0070113	E75.2	D052556	257220		We found that three miRNAs, miR-196a, miR-196b and miR-296 were up-regulated (>3.5-fold increase, p<0.05) whereas 38 miRNAs were significantly down-regulated in NPC cells (>3.5-fold decrease, p<0.05).
tissue_expression_up	hsa-mir-143	NUT Midline Carcinoma	29322795	disease of cellular proliferation	DOID:0060463					All NMCs showed upregulation of miR-9 and downregulation of miR-99a and miR-145 and two cases featured also upregulation of miR-21, miR-143, and miR-484
tissue_expression_up	hsa-mir-21	NUT Midline Carcinoma	29322795	disease of cellular proliferation	DOID:0060463					All NMCs showed upregulation of miR-9 and downregulation of miR-99a and miR-145 and two cases featured also upregulation of miR-21, miR-143, and miR-484
tissue_expression_up	hsa-mir-484	NUT Midline Carcinoma	29322795	disease of cellular proliferation	DOID:0060463					All NMCs showed upregulation of miR-9 and downregulation of miR-99a and miR-145 and two cases featured also upregulation of miR-21, miR-143, and miR-484
tissue_expression_up	hsa-mir-9	NUT Midline Carcinoma	29322795	disease of cellular proliferation	DOID:0060463					All NMCs showed upregulation of miR-9 and downregulation of miR-99a and miR-145 and two cases featured also upregulation of miR-21, miR-143, and miR-485
tissue_expression_up	hsa-let-7b	Obesity	26258540	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Specifically, miR-28, miR-26, and let-7b previously shown to inhibit sex steroid production in human granulosa cells, were up-regulated.
tissue_expression_up	hsa-mir-143	Obesity	18809385	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	miR-143: Up-regulated expression of microRNA-143 in association with obesity in adipose
tissue_expression_up	hsa-mir-18a	Obesity	22043006	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Two microRNA species (miR-18a, miR-30e) were up-regulated among obese individuals with a healthy periodontium.
tissue_expression_up	hsa-mir-199a	Obesity	27279151	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	miR鈥?99a鈥?p may represent a factor in the modulation of obesity鈥慳ssociated IR
tissue_expression_up	hsa-mir-21	Obesity	21426570	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	mir-21 is up-regulated in subcutaneous adipose tissue in human obesity
tissue_expression_up	hsa-mir-221	Obesity	23756832	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Human adipose microRNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-alpha
tissue_expression_up	hsa-mir-223	Obesity	27812198	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Visceral Adipose MicroRNA 223 Is Upregulated in Human and Murine Obesity and Modulates the Inflammatory Phenotype of Macrophages.
tissue_expression_up	hsa-mir-30e	Obesity	22043006	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	Two microRNA species (miR-18a, miR-30e) were up-regulated among obese individuals with a healthy periodontium.
tissue_expression_up	hsa-mir-335	Obesity	19460359	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	These findings provide the first evidence that the up-regulated expressions of miR-335 in liver and WAT of obese mice might contribute to the pathophysiology of obesity.
tissue_expression_up	hsa-mir-378	Obesity	24771406	disease of metabolism	DOID:9970	E66	D009765	601665	HP:0001513	TNF-α, IL-6, and leptin upregulated miR-378 expression indicating that miR-378 probably is a novel mediator in the development of insulin resistance related to obesity.
tissue_expression_up	hsa-mir-31	Oral Neoplasms	24480806			C06.9	D009062		HP:0100649	miR-31 is upregulated in oral premalignant epithelium and contributes to the immortalization of normal oral keratinocytes.
tissue_expression_up	hsa-mir-146a	Osteoarthritis	22006119	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	The relative expression levels of miR-146a, 155, 181a, and 223 in the OA patients were significantly higher than those found in healthy controls. In the early stages of OA, miR-146a and 223 expressions were significantly higher than they were at later stages. There was a significant correlation between the expression of miR-223 and KS. This study demonstrated that high expression levels of miR-146a, 155, 181a, and 223 in the PBMCs of OA patients might be related to the pathogenesis of OA.
tissue_expression_up	hsa-mir-146a	Osteoarthritis	22507670	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	IL-1β responsive miR-146a is overexpressed in an experimentally induced OA model, accompanied by upregulation of VEGF and downregulation of Smad4 in vivo.
tissue_expression_up	hsa-mir-146a	Osteoarthritis	26505891	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	miR-146a significantly up-regulated and  miR-27b significantly down-regulated at all time points
tissue_expression_up	hsa-mir-155	Osteoarthritis	22006119	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	The relative expression levels of miR-146a, 155, 181a, and 223 in the OA patients were significantly higher than those found in healthy controls. In the early stages of OA, miR-146a and 223 expressions were significantly higher than they were at later stages. There was a significant correlation between the expression of miR-223 and KS. This study demonstrated that high expression levels of miR-146a, 155, 181a, and 223 in the PBMCs of OA patients might be related to the pathogenesis of OA.
tissue_expression_up	hsa-mir-181a-1	Osteoarthritis	22006119	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	The relative expression levels of miR-146a, 155, 181a, and 223 in the OA patients were significantly higher than those found in healthy controls. In the early stages of OA, miR-146a and 223 expressions were significantly higher than they were at later stages. There was a significant correlation between the expression of miR-223 and KS. This study demonstrated that high expression levels of miR-146a, 155, 181a, and 223 in the PBMCs of OA patients might be related to the pathogenesis of OA.
tissue_expression_up	hsa-mir-181a-2	Osteoarthritis	22006119	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	The relative expression levels of miR-146a, 155, 181a, and 223 in the OA patients were significantly higher than those found in healthy controls. In the early stages of OA, miR-146a and 223 expressions were significantly higher than they were at later stages. There was a significant correlation between the expression of miR-223 and KS. This study demonstrated that high expression levels of miR-146a, 155, 181a, and 223 in the PBMCs of OA patients might be related to the pathogenesis of OA.
tissue_expression_up	hsa-mir-223	Osteoarthritis	22006119	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	The relative expression levels of miR-146a, 155, 181a, and 223 in the OA patients were significantly higher than those found in healthy controls. In the early stages of OA, miR-146a and 223 expressions were significantly higher than they were at later stages. There was a significant correlation between the expression of miR-223 and KS. This study demonstrated that high expression levels of miR-146a, 155, 181a, and 223 in the PBMCs of OA patients might be related to the pathogenesis of OA.
tissue_expression_up	hsa-mir-9	Osteoarthritis	25917063	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	These findings implicate miR-9-mediated suppression of MCPIP-1 in the pathogenesis of OA via up-regulation of IL-6 expression in IL-1β-stimulated human OA chondrocytes.
tissue_expression_up	hsa-mir-98	Osteoarthritis	27676099	musculoskeletal system disease	DOID:8398	M19.9	D010003	165720	HP:0002758	Upregulation of miR-98 Inhibits Apoptosis in Cartilage Cells in Osteoarthritis.
tissue_expression_up	hsa-mir-34a	Osteonecrosis	25612520	musculoskeletal system disease	DOID:10159	M87	D010020			The expression of miR-34a and miR-146a and genes in the predict pathways were significantly up-regulated.
tissue_expression_up	hsa-mir-143	Osteosarcoma	25562163	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	TGF-β1 up-regulates versican expression bysuppressing miR-143, and this pathway is important for osteosarcoma cell migration and invasion.
tissue_expression_up	hsa-mir-17	Osteosarcoma	22682620	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	up-regulated in osteosarcoma.
tissue_expression_up	hsa-mir-17	Osteosarcoma	24645838	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	Upregulation of microRNA-17-92 cluster associates with tumor progression and prognosis in osteosarcoma.
tissue_expression_up	hsa-mir-181a-1	Osteosarcoma	22350417	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	high expression
tissue_expression_up	hsa-mir-181a-2	Osteosarcoma	22350417	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	high expression
tissue_expression_up	hsa-mir-181b-1	Osteosarcoma	22350417	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	high expression
tissue_expression_up	hsa-mir-181b-2	Osteosarcoma	22350417	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	high expression
tissue_expression_up	hsa-mir-181c	Osteosarcoma	22350417	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	high expression
tissue_expression_up	hsa-mir-18a	Osteosarcoma	22682620	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	up-regulated in osteosarcoma.
tissue_expression_up	hsa-mir-196a	Osteosarcoma	24747591	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	Our present data indicate the involvement of miR-196a and miR-196b upregulation in the pathogenesis of osteosarcoma. More importantly, the altered levels of circulating miR-196a and miR-196b might have great potential to serve as novel and non-invasive prognostic factors for this malignancy.
tissue_expression_up	hsa-mir-196a	Osteosarcoma	25599934	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	the effects of miR-196a over-expression on tumour cell response may be strictly related to species and cell type. Further studies are needed to define the impact of miRNA deregulation on OS development.
tissue_expression_up	hsa-mir-196b	Osteosarcoma	24747591	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	Our present data indicate the involvement of miR-196a and miR-196b upregulation in the pathogenesis of osteosarcoma. More importantly, the altered levels of circulating miR-196a and miR-196b might have great potential to serve as novel and non-invasive prognostic factors for this malignancy.
tissue_expression_up	hsa-mir-19a	Osteosarcoma	22682620	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	up-regulated in osteosarcoma.
tissue_expression_up	hsa-mir-19b-1	Osteosarcoma	22682620	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	up-regulated in osteosarcoma.
tissue_expression_up	hsa-mir-20a	Osteosarcoma	22682620	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	up-regulated in osteosarcoma.
tissue_expression_up	hsa-mir-210	Osteosarcoma	23430441	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	miR-210 upregulation showed a strong correlation with tumor aggressive progression of pediatric osteosarcoma and could help prognostic screening of patients with this malignancy
tissue_expression_up	hsa-mir-9	Osteosarcoma	27051003	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	miR-9 was significantly upregulated in OS tissues and cell lines compared to the corresponding non-cancerous bone tissues
tissue_expression_up	hsa-mir-92a-1	Osteosarcoma	22682620	disease of cellular proliferation	DOID:3347		D012516	259500	HP:0002669	up-regulated in osteosarcoma.
tissue_expression_up	hsa-mir-146b	Otitis Media	27497395	nervous system disease	DOID:10754	H66.9	D010033	166760	HP:0000388	Middle ear miR-146a and miR-146b expression was elevated in otitis media patients relative to control subjects and correlated with middle ear epithelial thickness.
tissue_expression_up	hsa-mir-302c	Ovarian Germ Cell Cancer	29138809	endocrine system disease	DOID:2156			603737		Higher expression of miR-373-3p, miR-372-3p and miR-302c-3p and lower expression of miR-199a-5p, miR-214-5p and miR-202-3p were reproducibly observed in malignant OGCTs as compared to benign OGCTs or SCSTs
tissue_expression_up	hsa-mir-372	Ovarian Germ Cell Cancer	29138809	endocrine system disease	DOID:2156			603737		Higher expression of miR-373-3p, miR-372-3p and miR-302c-3p and lower expression of miR-199a-5p, miR-214-5p and miR-202-3p were reproducibly observed in malignant OGCTs as compared to benign OGCTs or SCSTs
tissue_expression_up	hsa-mir-373	Ovarian Germ Cell Cancer	29138809	endocrine system disease	DOID:2156			603737		Higher expression of miR-373-3p, miR-372-3p and miR-302c-3p and lower expression of miR-199a-5p, miR-214-5p and miR-202-3p were reproducibly observed in malignant OGCTs as compared to benign OGCTs or SCSTs
tissue_expression_up	hsa-let-7f	Ovarian Neoplasms	20716115	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets.
tissue_expression_up	hsa-mir-10b	Ovarian Neoplasms	23670532	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Loss of HOXD10 expression induced by upregulation of miR-10b accelerates the migration and invasion activities of ovarian cancer cells.
tissue_expression_up	hsa-mir-126	Ovarian Neoplasms	18954897	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-126: over-expressed
tissue_expression_up	hsa-mir-1299	Ovarian Neoplasms	21939554	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The miRNA was upregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines.
tissue_expression_up	hsa-mir-130a	Ovarian Neoplasms	22614869	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Altered microRNA expression in cisplatin-resistant ovarian cancer cells and upregulation of miR-130a associated with MDR1/P-glycoprotein-mediated drug resistance.
tissue_expression_up	hsa-mir-134	Ovarian Neoplasms	26363097	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	In conclusion, our findings indicate that repression of miR-134 and consequent up-regulation of Pak2 might contribute to paclitaxel resistance.
tissue_expression_up	hsa-mir-140	Ovarian Neoplasms	17875710	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs.
tissue_expression_up	hsa-mir-141	Ovarian Neoplasms	18451233	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Higher
tissue_expression_up	hsa-mir-141	Ovarian Neoplasms	17875710	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs.
tissue_expression_up	hsa-mir-141	Ovarian Neoplasms	29518404	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples
tissue_expression_up	hsa-mir-145	Ovarian Neoplasms	17875710	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs.
tissue_expression_up	hsa-mir-146a	Ovarian Neoplasms	22643117	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We found 37 differentially expressed miRNAs in the CD133(+) spheroid-forming subpopulation of OVCAR3 cells, 34 of which were significantly up-regulated, including miR-205, miR-146a, miR-200a, miR-200b, and miR-3, and 3 of which were significantly down-regulated, including miR-1202 and miR-1181.
tissue_expression_up	hsa-mir-146a	Ovarian Neoplasms	23554878	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	These observations suggest that at least two of the miRNAs, miR-146a and miR-150, up-regulated in omental lesions, stimulate survival and increase drug tolerance.
tissue_expression_up	hsa-mir-146b	Ovarian Neoplasms	29518404	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples
tissue_expression_up	hsa-mir-148b	Ovarian Neoplasms	22344713	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-148b was overexpressed in 92.21% (71/77) of the ovarian cancer samples examined, and overexpression of miR-148b in ovarian cancer tissues was not associated with any of the clinicopathological features of patients with ovarian cancer.
tissue_expression_up	hsa-mir-150	Ovarian Neoplasms	23554878	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	These observations suggest that at least two of the miRNAs, miR-146a and miR-150, up-regulated in omental lesions, stimulate survival and increase drug tolerance.
tissue_expression_up	hsa-mir-155	Ovarian Neoplasms	29518404	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples
tissue_expression_up	hsa-mir-155	Ovarian Neoplasms	23171795	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We found that in ovarian CAFs, miR-31 and miR-214 were downregulated, whereas miR-155 was upregulated when compared with normal or tumor-adjacent fibroblasts.
tissue_expression_up	hsa-mir-155	Ovarian Neoplasms	23230184	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	They found that decreased miR-31 and miR-214 and increased miR-155 expression can reprogram normal fibroblasts into tumor-promoting cancer-associated fibroblasts.
tissue_expression_up	hsa-mir-182	Ovarian Neoplasms	23262295	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The upregulation of signal transducer and activator of transcription 5-dependent microRNA-182 and microRNA-96 promotes ovarian cancer cell proliferation by targeting forkhead box O3 upon leptin stimulation
tissue_expression_up	hsa-mir-182	Ovarian Neoplasms	27295517	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-182 expression is significantly increased in EOC
tissue_expression_up	hsa-mir-182	Ovarian Neoplasms	20716115	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets.
tissue_expression_up	hsa-mir-183	Ovarian Neoplasms	21176563	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Increased expression of miR-183 and miR-22 may both repress the protein level of ezrin, indicating that miR-183 and miR-22 may bear a potential role in inhibiting ovarian cancer metastasis in a ezrin-mediated way
tissue_expression_up	hsa-mir-18a	Ovarian Neoplasms	18451233	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Higher
tissue_expression_up	hsa-mir-192	Ovarian Neoplasms	23766361	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The clear cell histotype is characterized by a five-fold (log scale) higher expression of miR-30a and miR-30a*, while mucinous histotype has five-fold (log scale) higher levels of miR-192/194. Furthermore a mucinous-specific regulatory loop involving miR-192/194 cluster and a differential regulation of E2F3 in clear cell histotype were identified.
tissue_expression_up	hsa-mir-192	Ovarian Neoplasms	29518404	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples
tissue_expression_up	hsa-mir-193b	Ovarian Neoplasms	21939554	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The miRNA was upregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines.
tissue_expression_up	hsa-mir-194-1	Ovarian Neoplasms	23766361	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The clear cell histotype is characterized by a five-fold (log scale) higher expression of miR-30a and miR-30a*, while mucinous histotype has five-fold (log scale) higher levels of miR-192/194. Furthermore a mucinous-specific regulatory loop involving miR-192/194 cluster and a differential regulation of E2F3 in clear cell histotype were identified.
tissue_expression_up	hsa-mir-194-2	Ovarian Neoplasms	23766361	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The clear cell histotype is characterized by a five-fold (log scale) higher expression of miR-30a and miR-30a*, while mucinous histotype has five-fold (log scale) higher levels of miR-192/194. Furthermore a mucinous-specific regulatory loop involving miR-192/194 cluster and a differential regulation of E2F3 in clear cell histotype were identified.
tissue_expression_up	hsa-mir-199a	Ovarian Neoplasms	17875710	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs.
tissue_expression_up	hsa-mir-200a	Ovarian Neoplasms	25374174	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-200a overexpression in advanced ovarian carcinomas as a prognostic indicator.
tissue_expression_up	hsa-mir-200a	Ovarian Neoplasms	17875710	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs.
tissue_expression_up	hsa-mir-200a	Ovarian Neoplasms	22643117	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We found 37 differentially expressed miRNAs in the CD133(+) spheroid-forming subpopulation of OVCAR3 cells, 34 of which were significantly up-regulated, including miR-205, miR-146a, miR-200a, miR-200b, and miR-3, and 3 of which were significantly down-regulated, including miR-1202 and miR-1181.
tissue_expression_up	hsa-mir-200b	Ovarian Neoplasms	17875710	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs.
tissue_expression_up	hsa-mir-200b	Ovarian Neoplasms	22643117	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We found 37 differentially expressed miRNAs in the CD133(+) spheroid-forming subpopulation of OVCAR3 cells, 34 of which were significantly up-regulated, including miR-205, miR-146a, miR-200a, miR-200b, and miR-3, and 3 of which were significantly down-regulated, including miR-1202 and miR-1181.
tissue_expression_up	hsa-mir-200c	Ovarian Neoplasms	17875710	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs.
tissue_expression_up	hsa-mir-200c	Ovarian Neoplasms	20716115	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets.
tissue_expression_up	hsa-mir-203	Ovarian Neoplasms	23918241	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Upregulation of microRNA-203 is associated with advanced tumor progression and poor prognosis in epithelial ovarian cancer.
tissue_expression_up	hsa-mir-205	Ovarian Neoplasms	22643117	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We found 37 differentially expressed miRNAs in the CD133(+) spheroid-forming subpopulation of OVCAR3 cells, 34 of which were significantly up-regulated, including miR-205, miR-146a, miR-200a, miR-200b, and miR-3, and 3 of which were significantly down-regulated, including miR-1202 and miR-1181.
tissue_expression_up	hsa-mir-21	Ovarian Neoplasms	18954897	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-21: over-expressed
tissue_expression_up	hsa-mir-21	Ovarian Neoplasms	18560586	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	we identify several miRNAs aberrantly expressed in human ovarian cancer tissues and cell lines. miR-221 stands out as a highly elevated miRNA in ovarian cancer, while miR-21 and several members of the let-7 family are found downregulated.
tissue_expression_up	hsa-mir-210	Ovarian Neoplasms	20716115	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets.
tissue_expression_up	hsa-mir-214	Ovarian Neoplasms	24479883	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Members of the miR-200 family, miR-182, miR-214 and miR-221 are frequently up-regulated, whereas miR-100, let-7i, miR-199a, miR-125b, mir-145 and miR-335 are often down-regulated in ovarian cancer compared with normal ovarian tissue.
tissue_expression_up	hsa-mir-22	Ovarian Neoplasms	21176563	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Increased expression of miR-183 and miR-22 may both repress the protein level of ezrin, indicating that miR-183 and miR-22 may bear a potential role in inhibiting ovarian cancer metastasis in a ezrin-mediated way
tissue_expression_up	hsa-mir-222	Ovarian Neoplasms	24137356	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1.
tissue_expression_up	hsa-mir-222	Ovarian Neoplasms	20716115	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets.
tissue_expression_up	hsa-mir-23a	Ovarian Neoplasms	20716115	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets.
tissue_expression_up	hsa-mir-27a	Ovarian Neoplasms	29518404	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples
tissue_expression_up	hsa-mir-27a	Ovarian Neoplasms	19446316	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	High expression of hsa-mir-27a identified a sub-group of patients with very poor prognosis.
tissue_expression_up	hsa-mir-29a	Ovarian Neoplasms	18954897	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-29a: over-expressed
tissue_expression_up	hsa-mir-29c	Ovarian Neoplasms	29518404	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples
tissue_expression_up	hsa-mir-3	Ovarian Neoplasms	22643117	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	We found 37 differentially expressed miRNAs in the CD133(+) spheroid-forming subpopulation of OVCAR3 cells, 34 of which were significantly up-regulated, including miR-205, miR-146a, miR-200a, miR-200b, and miR-3, and 3 of which were significantly down-regulated, including miR-1202 and miR-1181.
tissue_expression_up	hsa-mir-300	Ovarian Neoplasms	21939554	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The miRNA was upregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines.
tissue_expression_up	hsa-mir-30a	Ovarian Neoplasms	23766361	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The clear cell histotype is characterized by a five-fold (log scale) higher expression of miR-30a and miR-30a*, while mucinous histotype has five-fold (log scale) higher levels of miR-192/194. Furthermore a mucinous-specific regulatory loop involving miR-192/194 cluster and a differential regulation of E2F3 in clear cell histotype were identified.
tissue_expression_up	hsa-mir-30a	Ovarian Neoplasms	24479883	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Clear cell carcinoma has a significantly higher expression of miR-30a and miR-30a*, whereas mucinous histotype has elevated levels of miR-192/194.
tissue_expression_up	hsa-mir-34b	Ovarian Neoplasms	22340095	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The expressions of miR-449a/b, miR-34b and miR-34c were 19-fold to 21-fold elevated after p53 activation by genotoxic agent adriamycin.
tissue_expression_up	hsa-mir-34c	Ovarian Neoplasms	22340095	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The expressions of miR-449a/b, miR-34b and miR-34c were 19-fold to 21-fold elevated after p53 activation by genotoxic agent adriamycin.
tissue_expression_up	hsa-mir-429	Ovarian Neoplasms	18451233	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Higher
tissue_expression_up	hsa-mir-449a	Ovarian Neoplasms	22340095	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The expressions of miR-449a/b, miR-34b and miR-34c were 19-fold to 21-fold elevated after p53 activation by genotoxic agent adriamycin.
tissue_expression_up	hsa-mir-449b	Ovarian Neoplasms	22340095	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The expressions of miR-449a/b, miR-34b and miR-34c were 19-fold to 21-fold elevated after p53 activation by genotoxic agent adriamycin.
tissue_expression_up	hsa-mir-454	Ovarian Neoplasms	29518404	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples
tissue_expression_up	hsa-mir-486	Ovarian Neoplasms	29518404	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples
tissue_expression_up	hsa-mir-622	Ovarian Neoplasms	26774475	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer.
tissue_expression_up	hsa-mir-629	Ovarian Neoplasms	19946373	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	upregulated
tissue_expression_up	hsa-mir-642a	Ovarian Neoplasms	21939554	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The miRNA was upregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines.
tissue_expression_up	hsa-mir-9	Ovarian Neoplasms	24870723	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The present study provided evidence that curcumin exerts its cytotoxic effects against SKOV3 ovarian cancer cells largely through upregulation of miR-9 and subsequent modulation of Akt/FOXO1 axis. Further studies are needed to identify direct targets of miR-9 that mediate the anticancer effects of curcumin in ovarian cancer cells.
tissue_expression_up	hsa-mir-92b	Ovarian Neoplasms	18954897	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-92: over-expressed
tissue_expression_up	hsa-mir-93	Ovarian Neoplasms	18451233	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	Higher
tissue_expression_up	hsa-mir-93	Ovarian Neoplasms	18954897	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	miR-93: over-expressed
tissue_expression_up	hsa-mir-96	Ovarian Neoplasms	23262295	endocrine system disease	DOID:2394	C56	D010051	167000	HP:0100615	The upregulation of signal transducer and activator of transcription 5-dependent microRNA-182 and microRNA-96 promotes ovarian cancer cell proliferation by targeting forkhead box O3 upon leptin stimulation
tissue_expression_up	hsa-mir-196a	Pancreatic Intraductal Papillary Mucinous Neoplasms	24622064	disease of cellular proliferation	DOID:7575					Elevated expression of miR-196a in pancreatic juice samples is predictive of intestinal-type IPMNs.
tissue_expression_up	hsa-let-7a	Pancreatic Neoplasms	29596326	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		These effects were associated with increases in the expression of let-7a microRNA; suppression of K-Ras and survivin; and the elimination of drug-resistant cancer stem/tumor-initiating cells
tissue_expression_up	hsa-let-7a	Pancreatic Neoplasms	22108826	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer.
tissue_expression_up	hsa-let-7b	Pancreatic Neoplasms	22108826	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer.
tissue_expression_up	hsa-let-7c	Pancreatic Neoplasms	22108826	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer.
tissue_expression_up	hsa-let-7d	Pancreatic Neoplasms	22108826	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer.
tissue_expression_up	hsa-mir-100	Pancreatic Neoplasms	22466166	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions.
tissue_expression_up	hsa-mir-101	Pancreatic Neoplasms	22108826	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer.
tissue_expression_up	hsa-mir-103a	Pancreatic Neoplasms	26714641	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We identified suitable reference miRNAs for future miRNA expression experiments using CRC- and PC FFPE tissue samples. Formalin fixation decreased miRNA expression considerably, while the effect of increasing sample age was estimated to be negligible in a clinical setting.
tissue_expression_up	hsa-mir-106a	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-107	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-10a	Pancreatic Neoplasms	29169171	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-27a, miR-27b, miR-9, miR10a and miR-10b were up-regulated in PDAC cells compared to HPDE cells
tissue_expression_up	hsa-mir-10b	Pancreatic Neoplasms	22117151	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-10b is upregulated in pancreatic ductal adenocarcinoma and can be used as a diagnostic marker in endoscopic ultrasound-guided fine-needle aspiration biopsies of suspicious pancreatic lesions. In addition, miR-10b may be able to guide neoadjuvant gemcitabine-based chemoradiotherapy and predict metastatic-free survival and overall survival.
tissue_expression_up	hsa-mir-10b	Pancreatic Neoplasms	22910491	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		MicroRNA-10b is overexpressed in pancreatic cancer.
tissue_expression_up	hsa-mir-10b	Pancreatic Neoplasms	29169171	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-27a, miR-27b, miR-9, miR10a and miR-10b were up-regulated in PDAC cells compared to HPDE cells
tissue_expression_up	hsa-mir-128-2	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-1300	Pancreatic Neoplasms	22042419	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Among aberrantly expressed 122 microRNAs in IPMN, miR-552, miR-25*, miR-183, miR-1300, miR-196a, miR-182*, and miR-30c-1* were consistently increased more than 3-fold.
tissue_expression_up	hsa-mir-133a	Pancreatic Neoplasms	26214431	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression.
tissue_expression_up	hsa-mir-134	Pancreatic Neoplasms	22690071	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-95, miR-134 and miR-34c-3p are the top three miRNAs regulated by glargine (3.65-fold, 2.67-fold and 2.60-fold changes respectively, P < 0.01) in Sw1990 cells.
tissue_expression_up	hsa-mir-142	Pancreatic Neoplasms	21347785	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		patients with high miR-142-5p and miR-204 expression had significantly longer survival times than those with low miR-142-5p (P = 0.0077) and miR-204 (P = 0.0054) expression in the gemcitabine-treated group.
tissue_expression_up	hsa-mir-146a	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-146a	Pancreatic Neoplasms	22108826	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer.
tissue_expression_up	hsa-mir-146b	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-155	Pancreatic Neoplasms	22466166	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions.
tissue_expression_up	hsa-mir-155	Pancreatic Neoplasms	22850622	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed.
tissue_expression_up	hsa-mir-155	Pancreatic Neoplasms	22213426	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model
tissue_expression_up	hsa-mir-15a	Pancreatic Neoplasms	19551852	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		differentially expressed; associates with poorer survival
tissue_expression_up	hsa-mir-15b	Pancreatic Neoplasms	19030927	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-15b: upregulated
tissue_expression_up	hsa-mir-17	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-17	Pancreatic Neoplasms	20703102	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis, and involved in cancer cell proliferation and invasion
tissue_expression_up	hsa-mir-181b-1	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-181b-1	Pancreatic Neoplasms	22466166	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions.
tissue_expression_up	hsa-mir-181b-2	Pancreatic Neoplasms	22466166	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions.
tissue_expression_up	hsa-mir-182	Pancreatic Neoplasms	22042419	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Among aberrantly expressed 122 microRNAs in IPMN, miR-552, miR-25*, miR-183, miR-1300, miR-196a, miR-182*, and miR-30c-1* were consistently increased more than 3-fold.
tissue_expression_up	hsa-mir-183	Pancreatic Neoplasms	22042419	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Among aberrantly expressed 122 microRNAs in IPMN, miR-552, miR-25*, miR-183, miR-1300, miR-196a, miR-182*, and miR-30c-1* were consistently increased more than 3-fold.
tissue_expression_up	hsa-mir-186	Pancreatic Neoplasms	19030927	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-186: upregulated
tissue_expression_up	hsa-mir-190a	Pancreatic Neoplasms	19030927	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-190: upregulated
tissue_expression_up	hsa-mir-191	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-194-1	Pancreatic Neoplasms	21953293	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Highly up-regulated in PDAC compared with normal ductal
tissue_expression_up	hsa-mir-194-2	Pancreatic Neoplasms	21953293	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Highly up-regulated in PDAC compared with normal ductal
tissue_expression_up	hsa-mir-196a	Pancreatic Neoplasms	22042419	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Among aberrantly expressed 122 microRNAs in IPMN, miR-552, miR-25*, miR-183, miR-1300, miR-196a, miR-182*, and miR-30c-1* were consistently increased more than 3-fold.
tissue_expression_up	hsa-mir-196a-1	Pancreatic Neoplasms	19030927	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-196a: upregulated
tissue_expression_up	hsa-mir-196a-1	Pancreatic Neoplasms	22466166	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions.
tissue_expression_up	hsa-mir-196a-2	Pancreatic Neoplasms	19030927	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-196a: upregulated
tissue_expression_up	hsa-mir-196a-2	Pancreatic Neoplasms	22466166	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions.
tissue_expression_up	hsa-mir-196a-2	Pancreatic Neoplasms	17473300	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Finally, high expression of miR-196a-2 was found to predict poor survival (median, 14.3 months [95% confidence interval, 12.4-16.2] vs 26.5 months [95% confidence interval, 23.4-29.6]; P = .009).
tissue_expression_up	hsa-mir-199a-1	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-200b	Pancreatic Neoplasms	19030927	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-200b: upregulated
tissue_expression_up	hsa-mir-200b	Pancreatic Neoplasms	22108826	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer.
tissue_expression_up	hsa-mir-200c	Pancreatic Neoplasms	22108826	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer.
tissue_expression_up	hsa-mir-203	Pancreatic Neoplasms	19551852	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		differentially expressed; associates with poorer survival
tissue_expression_up	hsa-mir-204	Pancreatic Neoplasms	21347785	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		patients with high miR-142-5p and miR-204 expression had significantly longer survival times than those with low miR-142-5p (P = 0.0077) and miR-204 (P = 0.0054) expression in the gemcitabine-treated group.
tissue_expression_up	hsa-mir-20a	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-21	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-21	Pancreatic Neoplasms	17531469	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		MiR-21 is found to be highly expressed in numerous cancers like breast cancer, and glioblastoma and pancreatic cancer.
tissue_expression_up	hsa-mir-21	Pancreatic Neoplasms	18642050	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-21: MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival
tissue_expression_up	hsa-mir-21	Pancreatic Neoplasms	21463919	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype
tissue_expression_up	hsa-mir-21	Pancreatic Neoplasms	21983937	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miRNA-21 was the most significantly overexpressed miRNA in the pancreatic ductal adenocarcinomas analyzed, and was also highly expressed in 75% of the 65 pancreatic ductal adenocarcinomas examined by real-time RT-PCR. High miRNA-21 expression was correlated with a worse prognosis in the pancreatic ductal adenocarcinoma patients (P=0.045). The immunohistochemical expression patterns of PDCD4 (reduced nuclear staining pattern) and TIMP3 (downregulated expression) were significantly associated with both the upregulated miR-21 expression (P<0.05) and the poor survival of the patients (P<0.001 and P=0.001, respectively). Our data suggest that an overexpression of miRNA-21 is, therefore, associated with the biological behavior of pancreatic ductal adenocarcinoma via the downregulation of the expression of tumor suppressors, PDCD4 and TIMP3, thus resulting in tumor progression and the adverse clinical course of pancreatic ductal adenocarcinoma.
tissue_expression_up	hsa-mir-21	Pancreatic Neoplasms	22114136	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		In the initial cohort of 48 PDAC (pancreatic ductal adenocarcinoma) patients, high expression of miR-21 (Hazard ratio (HR): 3.22, 95% Confidence Interval (CI):1.21-8.58) and reduced expression of miR-34a (HR 0.15, 95%CI: 0.06-0.37) and miR-30d (HR:0.30, 95%CI:0.12-0.79) were associated with poor overall survival following resection independent of clinical covariates. In a further validation set of 24 patients miR-21 and miR-34a expression again significantly correlated with overall survival (P = 0.031 and P = 0.001).
tissue_expression_up	hsa-mir-21	Pancreatic Neoplasms	22466166	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions.
tissue_expression_up	hsa-mir-21	Pancreatic Neoplasms	22850622	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed.
tissue_expression_up	hsa-mir-21	Pancreatic Neoplasms	23272057	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Here, we show, for the first time, that hypoxia leads to increased expression of VEGF, IL-6, and CSC signature genes Nanog, Oct4 and EZH2 consistent with increased cell migration/invasion and angiogenesis, and the formation of pancreatospheres,concomitant with increased expression of miR-21 and miR-210 in human pancreatic cancer (PC) cells
tissue_expression_up	hsa-mir-21	Pancreatic Neoplasms	22213426	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model
tissue_expression_up	hsa-mir-210	Pancreatic Neoplasms	19551852	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		differentially expressed; associates with poorer survival
tissue_expression_up	hsa-mir-210	Pancreatic Neoplasms	21953293	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Highly up-regulated in PDAC compared with normal ductal
tissue_expression_up	hsa-mir-210	Pancreatic Neoplasms	22850622	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed.
tissue_expression_up	hsa-mir-210	Pancreatic Neoplasms	23272057	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Here, we show, for the first time, that hypoxia leads to increased expression of VEGF, IL-6, and CSC signature genes Nanog, Oct4 and EZH2 consistent with increased cell migration/invasion and angiogenesis, and the formation of pancreatospheres,concomitant with increased expression of miR-21 and miR-210 in human pancreatic cancer (PC) cells
tissue_expression_up	hsa-mir-214	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-214	Pancreatic Neoplasms	25304377	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Thirteen miRNAs (miR-138, miR-195, miR-204, miR-216a, miR-217, miR-218, miR-802, miR-155, miR-214, miR-26a, miR-30b, miR-31, and miR-125) were enriched and two miRNAs (miR-451a and miR-4284) were depleted in the cyst fluids derived from invasive carcinomas.
tissue_expression_up	hsa-mir-218	Pancreatic Neoplasms	25304377	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Thirteen miRNAs (miR-138, miR-195, miR-204, miR-216a, miR-217, miR-218, miR-802, miR-155, miR-214, miR-26a, miR-30b, miR-31, and miR-125) were enriched and two miRNAs (miR-451a and miR-4284) were depleted in the cyst fluids derived from invasive carcinomas.
tissue_expression_up	hsa-mir-221	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-221	Pancreatic Neoplasms	19030927	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-221: upregulated
tissue_expression_up	hsa-mir-221	Pancreatic Neoplasms	22466166	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions.
tissue_expression_up	hsa-mir-221	Pancreatic Neoplasms	22213426	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model
tissue_expression_up	hsa-mir-222	Pancreatic Neoplasms	19030927	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-222: upregulated
tissue_expression_up	hsa-mir-222	Pancreatic Neoplasms	19551852	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		differentially expressed; associates with poorer survival
tissue_expression_up	hsa-mir-222	Pancreatic Neoplasms	22850622	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed.
tissue_expression_up	hsa-mir-223	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-24-1	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-24-2	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-25	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-25	Pancreatic Neoplasms	22042419	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Among aberrantly expressed 122 microRNAs in IPMN, miR-552, miR-25*, miR-183, miR-1300, miR-196a, miR-182*, and miR-30c-1* were consistently increased more than 3-fold.
tissue_expression_up	hsa-mir-26a	Pancreatic Neoplasms	22108826	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer.
tissue_expression_up	hsa-mir-27a	Pancreatic Neoplasms	29169171	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-27a, miR-27b, miR-9, miR10a and miR-10b were up-regulated in PDAC cells compared to HPDE cells
tissue_expression_up	hsa-mir-27a	Pancreatic Neoplasms	22213426	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model
tissue_expression_up	hsa-mir-27b	Pancreatic Neoplasms	29169171	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-27a, miR-27b, miR-9, miR10a and miR-10b were up-regulated in PDAC cells compared to HPDE cells
tissue_expression_up	hsa-mir-27b	Pancreatic Neoplasms	22213426	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model
tissue_expression_up	hsa-mir-29b-1	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-301b	Pancreatic Neoplasms	27197190	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		PDAC tumors expressing high levels of MIF displayed elevated levels of miR-301b and reduced levels of NR3C2.
tissue_expression_up	hsa-mir-30b	Pancreatic Neoplasms	25304377	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Thirteen miRNAs (miR-138, miR-195, miR-204, miR-216a, miR-217, miR-218, miR-802, miR-155, miR-214, miR-26a, miR-30b, miR-31, and miR-125) were enriched and two miRNAs (miR-451a and miR-4284) were depleted in the cyst fluids derived from invasive carcinomas.
tissue_expression_up	hsa-mir-30c	Pancreatic Neoplasms	22042419	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Among aberrantly expressed 122 microRNAs in IPMN, miR-552, miR-25*, miR-183, miR-1300, miR-196a, miR-182*, and miR-30c-1* were consistently increased more than 3-fold.
tissue_expression_up	hsa-mir-30c-1	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-30c-2	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-32	Pancreatic Neoplasms	16461460	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		overexpressed
tissue_expression_up	hsa-mir-34c	Pancreatic Neoplasms	22690071	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-95, miR-134 and miR-34c-3p are the top three miRNAs regulated by glargine (3.65-fold, 2.67-fold and 2.60-fold changes respectively, P < 0.01) in Sw1990 cells.
tissue_expression_up	hsa-mir-425	Pancreatic Neoplasms	21953293	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Highly up-regulated in PDAC compared with normal ductal
tissue_expression_up	hsa-mir-429	Pancreatic Neoplasms	21953293	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Highly up-regulated in PDAC compared with normal ductal
tissue_expression_up	hsa-mir-451a	Pancreatic Neoplasms	22929886	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The expression of let-7c, let-7f, and miR-200c were significantly reduced in most patients whereas the expression of miR-486-5p and miR-451 were significantly elevated in all pancreas cancer patients.
tissue_expression_up	hsa-mir-451b	Pancreatic Neoplasms	22929886	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The expression of let-7c, let-7f, and miR-200c were significantly reduced in most patients whereas the expression of miR-486-5p and miR-451 were significantly elevated in all pancreas cancer patients.
tissue_expression_up	hsa-mir-486	Pancreatic Neoplasms	22929886	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		The expression of let-7c, let-7f, and miR-200c were significantly reduced in most patients whereas the expression of miR-486-5p and miR-451 were significantly elevated in all pancreas cancer patients.
tissue_expression_up	hsa-mir-552	Pancreatic Neoplasms	22042419	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Among aberrantly expressed 122 microRNAs in IPMN, miR-552, miR-25*, miR-183, miR-1300, miR-196a, miR-182*, and miR-30c-1* were consistently increased more than 3-fold.
tissue_expression_up	hsa-mir-7	Pancreatic Neoplasms	25256401	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells.
tissue_expression_up	hsa-mir-9	Pancreatic Neoplasms	29169171	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-27a, miR-27b, miR-9, miR10a and miR-10b were up-regulated in PDAC cells compared to HPDE cells
tissue_expression_up	hsa-mir-95	Pancreatic Neoplasms	19030927	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-95: upregulated
tissue_expression_up	hsa-mir-95	Pancreatic Neoplasms	22690071	disease of cellular proliferation	DOID:1793	C25.0-.2	D010190	260350		miR-95, miR-134 and miR-34c-3p are the top three miRNAs regulated by glargine (3.65-fold, 2.67-fold and 2.60-fold changes respectively, P < 0.01) in Sw1990 cells.
tissue_expression_up	hsa-mir-214	Pediatric Osteosarcoma	24038809	disease of cellular proliferation	DOID:3361					Our data offer evidence that upregulated expression of miR-214 may be linked to tumor progression and adverse prognosis in pediatric osteosarcoma.Further investigation in prospective studies would appear warranted.
tissue_expression_up	hsa-mir-106b	Periodontal Diseases	22043006	gastrointestinal system disease	DOID:3388	K05.6	D010510		HP:0000704	Two microRNA species (miR-30e, miR-106b) were up-regulated in non-obese individuals with periodontal disease.
tissue_expression_up	hsa-mir-30e	Periodontal Diseases	22043006	gastrointestinal system disease	DOID:3388	K05.6	D010510		HP:0000704	Two microRNA species (miR-30e, miR-106b) were up-regulated in non-obese individuals with periodontal disease.
tissue_expression_up	hsa-let-7a-1	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-let-7a-2	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-let-7a-3	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-let-7c	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-mir-130a	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-mir-181b-1	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-mir-181b-2	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-mir-19b-1	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-mir-19b-2	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-mir-21	Periodontitis	26987780	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Seven randomly selected up-regulated (miR-21-5p, 498, 548a-5p) and down-regulated (miR-495-3p, 539-5p, 34c-3p and 7a-2-3p) miRNAs were examined by qRT-PCR, and the results proved the accuracy of the miRNA
tissue_expression_up	hsa-mir-23a	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-mir-301a	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-mir-30a	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-mir-520d	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-mir-548a-1	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-mir-548a-2	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-mir-548a-3	Periodontitis	22128589	gastrointestinal system disease	DOID:824	K05.4	D010518	260950	HP:0000704	Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones.
tissue_expression_up	hsa-mir-101-1	Pheochromocytoma	22241719			C74.10	D010673	171300	HP:0002666	miR-483-5p, miR-183, and miR-101 had significantly higher expression in malignant tumors as compared to their benign counterparts.
tissue_expression_up	hsa-mir-101-2	Pheochromocytoma	22241719			C74.10	D010673	171300	HP:0002666	miR-483-5p, miR-183, and miR-101 had significantly higher expression in malignant tumors as compared to their benign counterparts.
tissue_expression_up	hsa-mir-183	Pheochromocytoma	22241719			C74.10	D010673	171300	HP:0002666	miR-483-5p, miR-183, and miR-101 had significantly higher expression in malignant tumors as compared to their benign counterparts.
tissue_expression_up	hsa-mir-483	Pheochromocytoma	22241719			C74.10	D010673	171300	HP:0002666	miR-483-5p, miR-183, and miR-101 had significantly higher expression in malignant tumors as compared to their benign counterparts.
tissue_expression_up	hsa-mir-451	Placenta Cancer	29805755	disease of cellular proliferation	DOID:2021	C58				The results showed that miR-451 and miR-720, highly expressed placental miRNAs, presented very low or undetectable expression in cancer cell lines compared to the normal placenta and healthy tissues
tissue_expression_up	hsa-mir-720	Placenta Cancer	29805755	disease of cellular proliferation	DOID:2021	C58				The results showed that miR-451 and miR-720, highly expressed placental miRNAs, presented very low or undetectable expression in cancer cell lines compared to the normal placenta and healthy tissues
tissue_expression_up	hsa-let-7b	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-let-7e	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-1228	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-144	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-195	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-203	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-30b	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-31	Pleural Mesothelioma	25358615	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	Upregulation of microRNA-31 associates with a poor prognosis of malignant pleural mesothelioma with sarcomatoid component.
tissue_expression_up	hsa-mir-32	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-340	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-345	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-34a	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-423	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-483	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-582	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-584	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-595	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-615	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-7-1	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-885	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-9	Pleural Mesothelioma	29462963	disease of cellular proliferation	DOID:7474	C45.0	D054363		HP:0100002	They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control
tissue_expression_up	hsa-mir-451	Polycythemia Vera	20218812	hematopoietic system disease	DOID:8997	D45	D011087	263300		We observed that miR-451 up-regulation and miR-150 down-regulation are associated with progression of erythroid maturation in K562 cells.
tissue_expression_up	hsa-let-7b	Preeclampsia	21309633	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b.
tissue_expression_up	hsa-mir-128-1	Preeclampsia	21309633	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b.
tissue_expression_up	hsa-mir-128-2	Preeclampsia	21309633	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b.
tissue_expression_up	hsa-mir-128a	Preeclampsia	27261578	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	miR-128a is an up-regulated miRNA in patient with PE.
tissue_expression_up	hsa-mir-133b	Preeclampsia	21309633	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b.
tissue_expression_up	hsa-mir-182	Preeclampsia	21309633	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b.
tissue_expression_up	hsa-mir-206	Preeclampsia	26213997	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Our pilot study has identified miRNA-206 as a novel factor upregulated in preeclampsia within the maternal circulation and in placental tissue.
tissue_expression_up	hsa-mir-21	Preeclampsia	21309633	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b.
tissue_expression_up	hsa-mir-21	Preeclampsia	26859593	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	we could observe a significant increase in gene expression of miR-155 (p<0.001), miR-21 (p<0.0001) and miR-122 (p<0.01) in preeclamptic placentas.
tissue_expression_up	hsa-mir-210	Preeclampsia	21388517	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease.
tissue_expression_up	hsa-mir-210	Preeclampsia	25015807	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	This increases the expression of miR-210 in the placenta causing repression of mitochondria-associated target genes, potentially leading to mitochondrial and placental dysfunction.
tissue_expression_up	hsa-mir-302a	Preeclampsia	21309633	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b.
tissue_expression_up	hsa-mir-302b	Preeclampsia	21309633	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b.
tissue_expression_up	hsa-mir-302c	Preeclampsia	21309633	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b.
tissue_expression_up	hsa-mir-302d	Preeclampsia	21309633	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b.
tissue_expression_up	hsa-mir-302e	Preeclampsia	21309633	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b.
tissue_expression_up	hsa-mir-302f	Preeclampsia	21309633	cardiovascular system disease	DOID:10591	O14	D011225	PS189800	HP:0100602	Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b.
tissue_expression_up	hsa-mir-299	Primary Biliary Cirrhosis	19345069	immune system disease	DOID:12236	K74.5	D008105	PS109720	HP:0002613	A total of 35 independent miRNAs were found to be differentially expressed in PBC (p < 0.001).Quantitative PCR was employed to validate down-regulation of microRNA-122a (miR-122a) and miR-26a and the increased expression of miR-328 and miR-299-5p.
tissue_expression_up	hsa-mir-328	Primary Biliary Cirrhosis	19345069	immune system disease	DOID:12236	K74.5	D008105	PS109720	HP:0002613	A total of 35 independent miRNAs were found to be differentially expressed in PBC (p < 0.001).Quantitative PCR was employed to validate down-regulation of microRNA-122a (miR-122a) and miR-26a and the increased expression of miR-328 and miR-299-5p.
tissue_expression_up	hsa-let-7b	Prion Diseases	22965126	nervous system disease	DOID:649	A81.9	D017096			we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes.
tissue_expression_up	hsa-let-7i	Prion Diseases	22965126	nervous system disease	DOID:649	A81.9	D017096			we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes.
tissue_expression_up	hsa-mir-128a	Prion Diseases	22965126	nervous system disease	DOID:649	A81.9	D017096			we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes.
tissue_expression_up	hsa-mir-21	Prion Diseases	22965126	nervous system disease	DOID:649	A81.9	D017096			we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes.
tissue_expression_up	hsa-mir-222	Prion Diseases	22965126	nervous system disease	DOID:649	A81.9	D017096			we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes.
tissue_expression_up	hsa-mir-29b	Prion Diseases	22965126	nervous system disease	DOID:649	A81.9	D017096			we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes.
tissue_expression_up	hsa-mir-342	Prion Diseases	22965126	nervous system disease	DOID:649	A81.9	D017096			we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes.
tissue_expression_up	hsa-mir-424	Prion Diseases	22965126	nervous system disease	DOID:649	A81.9	D017096			we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes.
tissue_expression_up	hsa-mir-206	Prolactinoma	22366961	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	miR-206 was significantly up-regulated in prolactinomas following bromocriptine treatment.
tissue_expression_up	hsa-mir-23b	Prolactinoma	22490835	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	up-regulated
tissue_expression_up	hsa-mir-342	Prolactinoma	22490835	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	miR-342-3p: up-regulated
tissue_expression_up	hsa-mir-432	Prolactinoma	22490835	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	up-regulated
tissue_expression_up	hsa-mir-493	Prolactinoma	22490835	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	up-regulated
tissue_expression_up	hsa-mir-516b-1	Prolactinoma	22366961	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	miR-516b was significantly up-regulated in prolactinomas following bromocriptine treatment.
tissue_expression_up	hsa-mir-516b-2	Prolactinoma	22366961	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	miR-516b was significantly up-regulated in prolactinomas following bromocriptine treatment.
tissue_expression_up	hsa-mir-550a-1	Prolactinoma	22366961	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	miR-516b was significantly up-regulated in prolactinomas following bromocriptine treatment.
tissue_expression_up	hsa-mir-550a-2	Prolactinoma	22366961	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	miR-550 was significantly up-regulated in prolactinomas following bromocriptine treatment.
tissue_expression_up	hsa-mir-664	Prolactinoma	22490835	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	miR-664*: up-regulated
tissue_expression_up	hsa-mir-671	Prolactinoma	22366961	disease of cellular proliferation	DOID:5394		D015175	600634	HP:0040278	miR-671-5p was significantly up-regulated in prolactinomas following bromocriptine treatment.
tissue_expression_up	hsa-mir-21	Proliferative Vitreoretinal Disease	27351379			H35.23				miR-21 expression positively  correlates with disease progression
tissue_expression_up	hsa-let-7b	Prostate Neoplasms	27157642	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	up-regulation of let-7b is characteristic of prostatic TAMs
tissue_expression_up	hsa-let-7c	Prostate Neoplasms	21255804	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Using the Cox regression test the risk of recurrence was 3.0, 3.3, 2.7 and 3.4 for high levels of miR-100, miR-145, miR-191 and miR-let7c, respectively.
tissue_expression_up	hsa-mir-100	Prostate Neoplasms	21255804	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Using the Cox regression test the risk of recurrence was 3.0, 3.3, 2.7 and 3.4 for high levels of miR-100, miR-145, miR-191 and miR-let7c, respectively.
tissue_expression_up	hsa-mir-106a	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-106b	Prostate Neoplasms	18676839	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-106b: significantly higher expression
tissue_expression_up	hsa-mir-107	Prostate Neoplasms	22240788	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-107 and miR-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
tissue_expression_up	hsa-mir-10a	Prostate Neoplasms	22999546	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-100 and miR-10a showed under expression and over expression, respectively, in low grade pTa tumors.
tissue_expression_up	hsa-mir-1207	Prostate Neoplasms	21592394	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated.
tissue_expression_up	hsa-mir-126	Prostate Neoplasms	21594291	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	In addition, anti-invasive microRNAs such as miR-335, miR-205, miR-200, and miR-126, were up-regulated, whereas pro-invasive microRNA such as miR-21 and miR-373, were down-regulated.
tissue_expression_up	hsa-mir-127	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-186a
tissue_expression_up	hsa-mir-134	Prostate Neoplasms	21592394	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated.
tissue_expression_up	hsa-mir-135b	Prostate Neoplasms	18949015	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-135b: up-regulated
tissue_expression_up	hsa-mir-143	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-184a
tissue_expression_up	hsa-mir-145	Prostate Neoplasms	22298119	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Significantly increased miR-145 expression were observed for patients with intermediate or high risk D'Amico scores compared to patients with low risk scores
tissue_expression_up	hsa-mir-145	Prostate Neoplasms	21255804	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Using the Cox regression test the risk of recurrence was 3.0, 3.3, 2.7 and 3.4 for high levels of miR-100, miR-145, miR-191 and miR-let7c, respectively.
tissue_expression_up	hsa-mir-146a	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-146b	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-155	Prostate Neoplasms	25938433	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	hsa-miR-155, hsa-miR-141 and hsa-miR-21 gene expressions were significantly elevated (66-85%, P<0.05) in tumor specimens
tissue_expression_up	hsa-mir-17	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-181a	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-191a
tissue_expression_up	hsa-mir-181b-1	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-182	Prostate Neoplasms	22045813	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells.
tissue_expression_up	hsa-mir-182	Prostate Neoplasms	25977730	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	MicroRNA expression profiling in primary PCa and morphological normal prostate (MNPT) tissues identified 17 miRNAs significantly overexpressed in PCa.
tissue_expression_up	hsa-mir-182	Prostate Neoplasms	23936432	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21.
tissue_expression_up	hsa-mir-183	Prostate Neoplasms	22045813	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells.
tissue_expression_up	hsa-mir-191	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-191	Prostate Neoplasms	21255804	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Using the Cox regression test the risk of recurrence was 3.0, 3.3, 2.7 and 3.4 for high levels of miR-100, miR-145, miR-191 and miR-let7c, respectively.
tissue_expression_up	hsa-mir-194-1	Prostate Neoplasms	18949015	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-194: up-regulated
tissue_expression_up	hsa-mir-194-2	Prostate Neoplasms	18949015	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-194: up-regulated
tissue_expression_up	hsa-mir-195	Prostate Neoplasms	26338045	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Collectively,this is the first report unveils that loss of miR-195 expression and thus uncontrolled BCOX1 upregulation might drive PCa metastasis.
tissue_expression_up	hsa-mir-199a-1	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-200	Prostate Neoplasms	21594291	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	In addition, anti-invasive microRNAs such as miR-335, miR-205, miR-200, and miR-126, were up-regulated, whereas pro-invasive microRNA such as miR-21 and miR-373, were down-regulated.
tissue_expression_up	hsa-mir-204	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-182a
tissue_expression_up	hsa-mir-205	Prostate Neoplasms	21594291	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	In addition, anti-invasive microRNAs such as miR-335, miR-205, miR-200, and miR-126, were up-regulated, whereas pro-invasive microRNA such as miR-21 and miR-373, were down-regulated.
tissue_expression_up	hsa-mir-20a	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-20a	Prostate Neoplasms	22298119	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-20a was significantly overexpressed in plasma from patients with stage 3 tumors compared to stage 2 or below (P=0.03).
tissue_expression_up	hsa-mir-21	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-21	Prostate Neoplasms	22298119	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The expression levels for miR-20a and miR-21 were significantly increased in patients with high risk CAPRA scores
tissue_expression_up	hsa-mir-21	Prostate Neoplasms	27040772	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	the expression level of miR-21 was significantly increased in PCa tissues
tissue_expression_up	hsa-mir-214	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-22	Prostate Neoplasms	21592394	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated.
tissue_expression_up	hsa-mir-221	Prostate Neoplasms	19351832	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-221: Overexpression
tissue_expression_up	hsa-mir-221	Prostate Neoplasms	22117988	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The level of ARHI mRNA was significantly lower in aggressive compared with non-aggressive prostate cancer tissue samples. In contrast, microRNA 221 and 222 levels were significantly higher in aggressive compared with non-aggressive prostate cancer tissue samples.
tissue_expression_up	hsa-mir-222	Prostate Neoplasms	19351832	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-222: Overexpression
tissue_expression_up	hsa-mir-222	Prostate Neoplasms	22117988	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The level of ARHI mRNA was significantly lower in aggressive compared with non-aggressive prostate cancer tissue samples. In contrast, microRNA 221 and 222 levels were significantly higher in aggressive compared with non-aggressive prostate cancer tissue samples.
tissue_expression_up	hsa-mir-223	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-25	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-25	Prostate Neoplasms	18676839	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-25: significantly higher expression
tissue_expression_up	hsa-mir-29a	Prostate Neoplasms	21592394	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated.
tissue_expression_up	hsa-mir-29b	Prostate Neoplasms	21592394	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated.
tissue_expression_up	hsa-mir-29b-1	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-301a	Prostate Neoplasms	22719071	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	upregulated in prostate cancer stem/progenitor cell.
tissue_expression_up	hsa-mir-301a	Prostate Neoplasms	26990571	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	High levels of miR-301a (above the median) were associated with an increased risk of biochemical recurrence
tissue_expression_up	hsa-mir-301a	Prostate Neoplasms	27327120	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	MiR-301a and miR-301b are 2 hypoxia responsive miRNAs that are significantly upregulated in hypoxia in prostate cancer cells.
tissue_expression_up	hsa-mir-301b	Prostate Neoplasms	22719071	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	upregulated in prostate cancer stem/progenitor cell.
tissue_expression_up	hsa-mir-301b	Prostate Neoplasms	27327120	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	MiR-301a and miR-301b are 2 hypoxia responsive miRNAs that are significantly upregulated in hypoxia in prostate cancer cells.
tissue_expression_up	hsa-mir-30c-1	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-30c-2	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-32	Prostate Neoplasms	16461460	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	overexpressed
tissue_expression_up	hsa-mir-32	Prostate Neoplasms	18676839	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-32: significantly higher expression
tissue_expression_up	hsa-mir-330	Prostate Neoplasms	21177307	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	We also observed a significant down-regulation of androgen-regulated miRNA-21 and up-regulation of a tumor suppressor, miRNA-330, in tumors of mice treated with EGCG
tissue_expression_up	hsa-mir-335	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-185a
tissue_expression_up	hsa-mir-335	Prostate Neoplasms	21594291	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	In addition, anti-invasive microRNAs such as miR-335, miR-205, miR-200, and miR-126, were up-regulated, whereas pro-invasive microRNA such as miR-21 and miR-373, were down-regulated.
tissue_expression_up	hsa-mir-371	Prostate Neoplasms	21592394	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated.
tissue_expression_up	hsa-mir-424	Prostate Neoplasms	24244675	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	MiR-424/503-mediated Rictor upregulation promotes tumor progression.
tissue_expression_up	hsa-mir-433	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-188a
tissue_expression_up	hsa-mir-451	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-189a
tissue_expression_up	hsa-mir-452	Prostate Neoplasms	22719071	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	upregulated in prostate cancer stem/progenitor cell.
tissue_expression_up	hsa-mir-503	Prostate Neoplasms	24244675	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	MiR-424/503-mediated Rictor upregulation promotes tumor progression.
tissue_expression_up	hsa-mir-542	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-187a
tissue_expression_up	hsa-mir-517a	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-181a
tissue_expression_up	hsa-mir-574	Prostate Neoplasms	22240788	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-107 and miR-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls.
tissue_expression_up	hsa-mir-582	Prostate Neoplasms	25176332	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	Our results suggest that up-regulation of miR-582-5p contributes to an increase in the proliferation of prostate cancer cells under androgen deprived conditions.
tissue_expression_up	hsa-mir-629	Prostate Neoplasms	19946373	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	upregulated
tissue_expression_up	hsa-mir-885	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-183a
tissue_expression_up	hsa-mir-92a	Prostate Neoplasms	29568403	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-190a
tissue_expression_up	hsa-mir-93	Prostate Neoplasms	18676839	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	miR-93: significantly higher expression
tissue_expression_up	hsa-mir-96	Prostate Neoplasms	22045813	disease of cellular proliferation	DOID:10283	C51	D011471	176807	HP:0100787	The miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells.
tissue_expression_up	hsa-mir-125b	Psoriasis	21373745	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	Real-time PCR and immunohistochemistry showed that p63 expression was not significantly affected, whereas NB-UVB phototherapy significantly decreased expression ofmiR-21 (p = 0.003) and increased miR-125b levels (p = 0.003). The results indicate that the unresolved p63 abnormality in treated epidermis may play a role in maintenance of this disease.
tissue_expression_up	hsa-mir-146a	Psoriasis	17622355	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	miR-146a was significantly over-expressed in psoriatic lesional skin p<0.001) but not in atopic eczema lesions when compared with healthy skin.
tissue_expression_up	hsa-mir-155	Psoriasis	27706699	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	Increased miR-155-5p expression in dermal mesenchymal stem cells of psoriatic patients: comparing the microRNA expression profile by microarray.
tissue_expression_up	hsa-mir-203	Psoriasis	17622355	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	upregulation (lead to downregulation of its target SOCS3)
tissue_expression_up	hsa-mir-203	Psoriasis	23608026	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	MiR-203 is a miRNA preferentially expressed in the skin, and an important regulator of keratinocyte differentiation. MiR-203 has been implicated in skin diseases, in particular in psoriasis in which it is overexpressed, and in basal cell carcinoma where it acts as a tumor suppressor miRNA.
tissue_expression_up	hsa-mir-203	Psoriasis	27729619	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	upregulation of miR-31/miR-203 and downregulation of hsa-miR-99a/miR-125b work together in concert to facilitate the development of psoriasis pathogenesis
tissue_expression_up	hsa-mir-21	Psoriasis	17622355	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	miR-21 was significantly up-regulated both psoriasis (p<0.001) and atopic eczema (p<0.001) as compared with healthy skin.
tissue_expression_up	hsa-mir-21	Psoriasis	22417311	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	MiR-21 is up-regulated in psoriasis and suppresses T cell apoptosis.
tissue_expression_up	hsa-mir-31	Psoriasis	27729619	integumentary system disease	DOID:8893	L40.9	D011565	PS177900	HP:0003765	upregulation of miR-31/miR-203 and downregulation of hsa-miR-99a/miR-125b work together in concert to facilitate the development of psoriasis pathogenesis
tissue_expression_up	hsa-mir-130a	Pulmonary Hypertension	23717609	cardiovascular system disease	DOID:6432	I27.20	D006976	PS178600	HP:0002092	We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects.
tissue_expression_up	hsa-mir-191	Pulmonary Hypertension	23717609	cardiovascular system disease	DOID:6432	I27.20	D006976	PS178600	HP:0002092	We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects.
tissue_expression_up	hsa-mir-199a	Pulmonary Hypertension	27162619	cardiovascular system disease	DOID:6432	I27.20	D006976	PS178600	HP:0002092	All 4 miRNAs were upregulated in the lung and right ventricle
tissue_expression_up	hsa-mir-23b	Pulmonary Hypertension	23717609	cardiovascular system disease	DOID:6432	I27.20	D006976	PS178600	HP:0002092	We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects.
tissue_expression_up	hsa-mir-1183	Rectal Neoplasms	22172905	disease of cellular proliferation	DOID:1984		D012004			Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases.
tissue_expression_up	hsa-mir-1224	Rectal Neoplasms	22172905	disease of cellular proliferation	DOID:1984		D012004			Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases.
tissue_expression_up	hsa-mir-125a	Rectal Neoplasms	22172905	disease of cellular proliferation	DOID:1984		D012004			Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases.
tissue_expression_up	hsa-mir-1471	Rectal Neoplasms	22172905	disease of cellular proliferation	DOID:1984		D012004			Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases.
tissue_expression_up	hsa-mir-155	Rectal Neoplasms	25261908	disease of cellular proliferation	DOID:1984		D012004			Increase in the expression of miR-155 might represent a potential valuable marker for rectal carcinoma N and combined tumor-node-metastasis staging.
tissue_expression_up	hsa-mir-188	Rectal Neoplasms	22172905	disease of cellular proliferation	DOID:1984		D012004			Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases.
tissue_expression_up	hsa-mir-1909	Rectal Neoplasms	22172905	disease of cellular proliferation	DOID:1984		D012004			Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases.
tissue_expression_up	hsa-mir-483	Rectal Neoplasms	22172905	disease of cellular proliferation	DOID:1984		D012004			Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases.
tissue_expression_up	hsa-mir-622	Rectal Neoplasms	22172905	disease of cellular proliferation	DOID:1984		D012004			Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases.
tissue_expression_up	hsa-mir-630	Rectal Neoplasms	22172905	disease of cellular proliferation	DOID:1984		D012004			Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases.
tissue_expression_up	hsa-mir-671	Rectal Neoplasms	22172905	disease of cellular proliferation	DOID:1984		D012004			Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases.
tissue_expression_up	hsa-mir-765	Rectal Neoplasms	22172905	disease of cellular proliferation	DOID:1984		D012004			Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases.
tissue_expression_up	hsa-mir-155	Renal Fibrosis	27158339	urinary system disease	DOID:0050855	N26.9			HP:0030760	MiR-155 levels were higher in UUO mouse kidneys
tissue_expression_up	hsa-mir-21	Renal Fibrosis	21775484	urinary system disease	DOID:0050855	N26.9			HP:0030760	miR-21 expression was upregulated in response to treatment with TGF-beta1 or TNF-alpha in human renal tubular epithelial cells in vitro.
tissue_expression_up	hsa-mir-125a	Retinal Degeneration	20053268	nervous system disease	DOID:8466	H35.40	D012162	605670	HP:0000546	Over-expression
tissue_expression_up	hsa-mir-204	Retinal Degeneration	20053268	nervous system disease	DOID:8466	H35.40	D012162	605670	HP:0000546	Over-expression
tissue_expression_up	hsa-mir-150	Retinal Neovascularization	18500251			H35.059	D015861		HP:0030666	increased
tissue_expression_up	hsa-mir-184	Retinal Neovascularization	18500251			H35.059	D015861		HP:0030666	increased
tissue_expression_up	hsa-mir-31	Retinal Neovascularization	18500251			H35.059	D015861		HP:0030666	increased
tissue_expression_up	hsa-mir-451a	Retinal Neovascularization	18500251			H35.059	D015861		HP:0030666	increased
tissue_expression_up	hsa-mir-183	Retinitis Pigmentosa	18034880	nervous system disease	DOID:10584	H35.52	D012174	PS268000	HP:0000510	Expression of miR-1 and miR-133 decreased by more than 2.5-fold (P < 0.001), whereas expression of miR-96 and miR-183 increased by more than 3-fold (P < 0.001) in Pro347Ser retinas, as validated by qPCR.
tissue_expression_up	hsa-mir-96	Retinitis Pigmentosa	18034880	nervous system disease	DOID:10584	H35.52	D012174	PS268000	HP:0000510	Expression of miR-1 and miR-133 decreased by more than 2.5-fold (P < 0.001), whereas expression of miR-96 and miR-183 increased by more than 3-fold (P < 0.001) in Pro347Ser retinas, as validated by qPCR.
tissue_expression_up	hsa-let-7c	Retinoblastoma	21941147	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth.
tissue_expression_up	hsa-let-7i	Retinoblastoma	21941147	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth.
tissue_expression_up	hsa-mir-10b	Retinoblastoma	21941147	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth.
tissue_expression_up	hsa-mir-124-1	Retinoblastoma	21941147	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth.
tissue_expression_up	hsa-mir-124-2	Retinoblastoma	21941147	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth.
tissue_expression_up	hsa-mir-124-3	Retinoblastoma	21941147	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth.
tissue_expression_up	hsa-mir-125a	Retinoblastoma	21373755	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	We identified a cluster of miRNAs that includes miR-181b, miR-125a-3p, miR-30c-2, miR-497 and miR-491-3p as hypoxia-regulated miRNAs (HRMs) in retinoblastoma cells, of which miR-181b was the most typically differentially expressed miRNA under hypoxic conditions.
tissue_expression_up	hsa-mir-135b	Retinoblastoma	21941147	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth.
tissue_expression_up	hsa-mir-142	Retinoblastoma	21941147	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	hsa-mir-142-5p: differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth.
tissue_expression_up	hsa-mir-181b-1	Retinoblastoma	21373755	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	We identified a cluster of miRNAs that includes miR-181b, miR-125a-3p, miR-30c-2, miR-497 and miR-491-3p as hypoxia-regulated miRNAs (HRMs) in retinoblastoma cells, of which miR-181b was the most typically differentially expressed miRNA under hypoxic conditions.
tissue_expression_up	hsa-mir-181b-2	Retinoblastoma	21373755	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	We identified a cluster of miRNAs that includes miR-181b, miR-125a-3p, miR-30c-2, miR-497 and miR-491-3p as hypoxia-regulated miRNAs (HRMs) in retinoblastoma cells, of which miR-181b was the most typically differentially expressed miRNA under hypoxic conditions.
tissue_expression_up	hsa-mir-29a	Retinoblastoma	21941147	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth.
tissue_expression_up	hsa-mir-29b-1	Retinoblastoma	21941147	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth.
tissue_expression_up	hsa-mir-29b-2	Retinoblastoma	21941147	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth.
tissue_expression_up	hsa-mir-29c	Retinoblastoma	21941147	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth.
tissue_expression_up	hsa-mir-30c-2	Retinoblastoma	21373755	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	We identified a cluster of miRNAs that includes miR-181b, miR-125a-3p, miR-30c-2, miR-497 and miR-491-3p as hypoxia-regulated miRNAs (HRMs) in retinoblastoma cells, of which miR-181b was the most typically differentially expressed miRNA under hypoxic conditions.
tissue_expression_up	hsa-mir-34a	Retinoblastoma	21941147	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth.
tissue_expression_up	hsa-mir-34c	Retinoblastoma	21941147	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	hsa-mir-34c-5p: differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth.
tissue_expression_up	hsa-mir-491	Retinoblastoma	21373755	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	We identified a cluster of miRNAs that includes miR-181b, miR-125a-3p, miR-30c-2, miR-497 and miR-491-3p as hypoxia-regulated miRNAs (HRMs) in retinoblastoma cells, of which miR-181b was the most typically differentially expressed miRNA under hypoxic conditions.
tissue_expression_up	hsa-mir-497	Retinoblastoma	21373755	nervous system disease	DOID:768	C69.20	D012175	180200	HP:0009919	We identified a cluster of miRNAs that includes miR-181b, miR-125a-3p, miR-30c-2, miR-497 and miR-491-3p as hypoxia-regulated miRNAs (HRMs) in retinoblastoma cells, of which miR-181b was the most typically differentially expressed miRNA under hypoxic conditions.
tissue_expression_up	hsa-mir-1-1	Rhabdomyosarcoma	20466878	disease of cellular proliferation	DOID:3247	M62.82	D012208	268220	HP:0002859	miR-1:mRNA targets of miR-1 and miR-133a are up-regulated in rhabdomyosarcomas
tissue_expression_up	hsa-mir-1-2	Rhabdomyosarcoma	20466878	disease of cellular proliferation	DOID:3247	M62.82	D012208	268220	HP:0002859	miR-1:mRNA targets of miR-1 and miR-133a are up-regulated in rhabdomyosarcomas
tissue_expression_up	hsa-mir-133a-1	Rhabdomyosarcoma	20466878	disease of cellular proliferation	DOID:3247	M62.82	D012208	268220	HP:0002859	miR-133a:mRNA targets of miR-1 and miR-133a are up-regulated in rhabdomyosarcomas
tissue_expression_up	hsa-mir-146a	Rheumatoid Arthritis	18759964	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	miR-146a: Upregulated miR-146a expression in peripheral blood mononuclear cells
tissue_expression_up	hsa-mir-146a	Rheumatoid Arthritis	21810022	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	miRNA 146a expression was significantly higher in patients with RA than in those with OA and in controls.In patients with RA, miRNA 146a positively correlated with TNF-a (p=0.0003), erythrocyte sedimentation rate (ESR)(p=0.022), and DAS 28 (p=0.009).
tissue_expression_up	hsa-mir-146a	Rheumatoid Arthritis	18383392	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	This study provides the first description of increased expression of miRNA miR-155 and miR-146a in RA.
tissue_expression_up	hsa-mir-146a	Rheumatoid Arthritis	27079198	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	miR-146a, miR-155, and miR-223 were significantly elevated in RA compared to OA synovial tissues
tissue_expression_up	hsa-mir-155	Rheumatoid Arthritis	21690378	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	miR-155 is up-regulated in synovial membrane and synovial fluid (SF) macrophages from patients with rheumatoid arthritis (RA). The increased expression of miR-155 in SF CD14(+) cells was associated with lower expression of the miR-155 target, Src homology 2-containing inositol phosphatase-1 (SHIP-1), an inhibitor of inflammation.
tissue_expression_up	hsa-mir-155	Rheumatoid Arthritis	24151514	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	An inflammatory milieu may alter miRNA expression profiles in rheumatoid arthritis. miR-155 is upregulated in RA-FLS, and it may be a protective factor against the inflammatory effect in part by attenuating expression of IKBKE.
tissue_expression_up	hsa-mir-155	Rheumatoid Arthritis	24909288	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	TPT suppressed the expression of miR-155 and up-regulated the release of SHIP-1, thus inhibiting the inflammatory response in the LPS-stimulated monocytes of RA patients.
tissue_expression_up	hsa-mir-155	Rheumatoid Arthritis	18383392	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	This study provides the first description of increased expression of miRNA miR-155 and miR-146a in RA.
tissue_expression_up	hsa-mir-155	Rheumatoid Arthritis	27079198	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	miR-146a, miR-155, and miR-223 were significantly elevated in RA compared to OA synovial tissues
tissue_expression_up	hsa-mir-16	Rheumatoid Arthritis	27875659	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	Upregulated Expression of microRNA-16 Correlates with Th17/Treg Cell Imbalance in Patients with Rheumatoid Arthritis.
tissue_expression_up	hsa-mir-223	Rheumatoid Arthritis	22032299	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	miR-223 is overexpressed in T-lymphocytes of early rheumatoid arthritis patients.
tissue_expression_up	hsa-mir-223	Rheumatoid Arthritis	19931339	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	miR-223 is overexpressed in T-lymphocytes of patients affected by rheumatoid arthritis.
tissue_expression_up	hsa-mir-223	Rheumatoid Arthritis	27079198	musculoskeletal system disease	DOID:7148	M06.9	D001172	180300	HP:0001370	miR-146a, miR-155, and miR-223 were significantly elevated in RA compared to OA synovial tissues
tissue_expression_up	hsa-mir-140	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-140: up-regulated
tissue_expression_up	hsa-mir-154	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-154: up-regulated
tissue_expression_up	hsa-mir-188	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-188: up-regulated
tissue_expression_up	hsa-mir-21	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-21: up-regulated
tissue_expression_up	hsa-mir-21	Salivary Gland Neoplasms	27184509	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	tissue samples were studied miR-21, miR-31, miR-199a-5p, miR-146b, miR-345 were up-regulated
tissue_expression_up	hsa-mir-23b	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-23b: up-regulated
tissue_expression_up	hsa-mir-299	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-299-3p: up-regulated
tissue_expression_up	hsa-mir-29c	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-29c: up-regulated
tissue_expression_up	hsa-mir-301a	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-301: up-regulated
tissue_expression_up	hsa-mir-301b	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-301: up-regulated
tissue_expression_up	hsa-mir-302c	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-302c: up-regulated
tissue_expression_up	hsa-mir-337	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-337: up-regulated
tissue_expression_up	hsa-mir-376a-1	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-376a: up-regulated
tissue_expression_up	hsa-mir-376a-2	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-376a: up-regulated
tissue_expression_up	hsa-mir-409	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-409-3p: up-regulated
tissue_expression_up	hsa-mir-449a	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-449: up-regulated
tissue_expression_up	hsa-mir-449b	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-449: up-regulated
tissue_expression_up	hsa-mir-495	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-495: up-regulated
tissue_expression_up	hsa-mir-99b	Salivary Gland Neoplasms	19347935	gastrointestinal system disease	DOID:8850	C08	D012468	603641	HP:0100684	miR-99b: up-regulated
tissue_expression_up	hsa-mir-128	Salmonellosis	24415783	disease by infectious agent	DOID:0060859	A02.0	D012480			Salmonella can upregulate intestinal epithelial miR-128 expression,which, in turn, decreases levels of epithelial cell-secreted M-CSF and M-CSF-induced macrophage recruitment. mir-9-5p
tissue_expression_up	hsa-mir-200a	Sarcoma [unspecific]	27402864	disease of cellular proliferation	DOID:1115	C49	D012509		HP:0100242	combined expression of miR-200s and GRHL2 further upregulates epithelial genes to induce MET.
tissue_expression_up	hsa-mir-200b	Sarcoma [unspecific]	27402864	disease of cellular proliferation	DOID:1115	C49	D012509		HP:0100242	combined expression of miR-200s and GRHL2 further upregulates epithelial genes to induce MET.
tissue_expression_up	hsa-mir-200c	Sarcoma [unspecific]	27402864	disease of cellular proliferation	DOID:1115	C49	D012509		HP:0100242	combined expression of miR-200s and GRHL2 further upregulates epithelial genes to induce MET.
tissue_expression_up	hsa-mir-141	Sarcoma [unspecific]	27402864	disease of cellular proliferation	DOID:1115	C49	D012509		HP:0100242	combined expression of miR-200s and GRHL2 further upregulates epithelial genes to induce MET.
tissue_expression_up	hsa-mir-429	Sarcoma [unspecific]	27402864	disease of cellular proliferation	DOID:1115	C49	D012509		HP:0100242	combined expression of miR-200s and GRHL2 further upregulates epithelial genes to induce MET.
tissue_expression_up	hsa-mir-210	Sarcoma [unspecific]	21455991	disease of cellular proliferation	DOID:1115	C49	D012509		HP:0100242	Expression of microRNA 210 associates with poor survival and age of tumor onset of soft-tissue sarcoma patients.
tissue_expression_up	hsa-let-7g	Schizophrenia	18184693	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	upregulated
tissue_expression_up	hsa-mir-106b	Schizophrenia	17326821	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	upregulation
tissue_expression_up	hsa-mir-29c	Schizophrenia	23382797	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	RT-PCR validation confirmed that two miRNAs, miR-497 in SZ samples and miR-29c in BD samples, have significantly increased expression when compared to control samples. These results warrant future studies to evaluate the potential of exosome-derived miRNAs to serve as biomarkers of SZ and BD.
tissue_expression_up	hsa-mir-497	Schizophrenia	23382797	disease of mental health	DOID:5419	F20	D012559	181500	HP:0100753	RT-PCR validation confirmed that two miRNAs, miR-497 in SZ samples and miR-29c in BD samples, have significantly increased expression when compared to control samples. These results warrant future studies to evaluate the potential of exosome-derived miRNAs to serve as biomarkers of SZ and BD.
tissue_expression_up	hsa-mir-214	Scleroderma, Localized	26498408	musculoskeletal system disease	DOID:8472	L94.0	D012594			The levels of miR-214 in hair shafts of patients with dermatomyositis were significantly higher than those of normal subjects and patients with scleroderma.
tissue_expression_up	hsa-mir-155	Scleroderma, Systemic	29559981	musculoskeletal system disease	DOID:418	M34	D012595	181750		miR-21-5p, miR-92a-3p, miR-155-5p, and miR-16-5p expression was significantly higher in SSc sera compared to healthy controls
tissue_expression_up	hsa-mir-16	Scleroderma, Systemic	29559981	musculoskeletal system disease	DOID:418	M34	D012595	181750		miR-21-5p, miR-92a-3p, miR-155-5p, and miR-16-5p expression was significantly higher in SSc sera compared to healthy controls
tissue_expression_up	hsa-mir-21	Scleroderma, Systemic	29559981	musculoskeletal system disease	DOID:418	M34	D012595	181750		miR-21-5p, miR-92a-3p, miR-155-5p, and miR-16-5p expression was significantly higher in SSc sera compared to healthy controls
tissue_expression_up	hsa-mir-92a	Scleroderma, Systemic	29559981	musculoskeletal system disease	DOID:418	M34	D012595	181750		miR-21-5p, miR-92a-3p, miR-155-5p, and miR-16-5p expression was significantly higher in SSc sera compared to healthy controls
tissue_expression_up	hsa-mir-92a-1	Scleroderma, Systemic	22661558	musculoskeletal system disease	DOID:418	M34	D012595	181750		microRNA-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma.
tissue_expression_up	hsa-mir-92a-2	Scleroderma, Systemic	22661558	musculoskeletal system disease	DOID:418	M34	D012595	181750		microRNA-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma.
tissue_expression_up	hsa-mir-184	Sebaceous Carcinoma	26203913	disease of cellular proliferation	DOID:4840	C44			HP:0030410	Serial testing and validation confirmed overexpression of 2 miRNAs previously reported to be oncogenic, miR-486-5p (4.4-fold; P鈥?鈥?.4鈥壝椻€?0-8) and miR-184 (3.5-fold; P鈥?鈥?.7鈥壝椻€?0-6)
tissue_expression_up	hsa-mir-34b	Seizures	27514646			G40.89	D012640		HP:0001250	We discovered that miR-34b-5p, a member of the miR-34 family, increased  significantly in flurothyl-treated rat hippocampus tissue.
tissue_expression_up	hsa-mir-372	Seminoma	23064661	disease of cellular proliferation	DOID:4440	C62.90	D018239	273300	HP:0100617	Hsa-mir-372 was upregulated around 1,270-fold (95 % confidence interval (CI) 525.2-3,064.8; sp = 8.1e-5 by Mann-Whitney U test)
tissue_expression_up	hsa-mir-143	Sepsis	25043848			A41.9	D018805		HP:0100806	Through microRNA microarray and qRT-PCR we found that the levels of miR-27a, miR-153 and  miR-143 are up regulated, while let-7a, miR-218 and miR-129-5p are down regulated in lungs of septic mice.
tissue_expression_up	hsa-mir-146a	Sepsis	23596477			A41.9	D018805		HP:0100806	We observed a significant increase in miR-146a expression in the initial cohort of 6 non-sepsis-SIRS patients compared to the 4 sepsis patients(P=0.01) 
tissue_expression_up	hsa-mir-21	Sezary Disease	21525938	disease of cellular proliferation	DOID:8541	C84.1	D012751			MicroRNA profiling reveals that miR-21, miR-486 and miR-214 are upregulated and involved in cell survival in Sezary Syndrome.
tissue_expression_up	hsa-mir-214	Sezary Disease	21525938	disease of cellular proliferation	DOID:8541	C84.1	D012751			MicroRNA profiling reveals that miR-21, miR-486 and miR-214 are upregulated and involved in cell survival in Sezary Syndrome.
tissue_expression_up	hsa-mir-486	Sezary Disease	21525938	disease of cellular proliferation	DOID:8541	C84.1	D012751			MicroRNA profiling reveals that miR-21, miR-486 and miR-214 are upregulated and involved in cell survival in Sezary Syndrome.
tissue_expression_up	hsa-mir-126	Shock, Hemorrhagic	27345902				D012771			miR-29a and miR-126 were upregulated
tissue_expression_up	hsa-mir-29a	Shock, Hemorrhagic	27345902				D012771			miR-29a and miR-126 were upregulated
tissue_expression_up	hsa-mir-146a	Sjogren Syndrome	21469088	immune system disease	DOID:12894	M35.00	D012859	270150		Altered miR-146a expression in Sjogren's syndrome
tissue_expression_up	hsa-mir-146a	Sjogren Syndrome	22033216	immune system disease	DOID:12894	M35.00	D012859	270150		We found that both miR-146a and miR-146b, furthermore, the gene of TRAF6 were significantly overexpressed in the Sjogren's patients, whereas the expression of IRAK1 gene was significantly decreased.
tissue_expression_up	hsa-mir-146b	Sjogren Syndrome	22033216	immune system disease	DOID:12894	M35.00	D012859	270150		We found that both miR-146a and miR-146b, furthermore, the gene of TRAF6 were significantly overexpressed in the Sjogren's patients, whereas the expression of IRAK1 gene was significantly decreased.
tissue_expression_up	hsa-mir-206	Soft Tissue Sarcoma	27223121			C49.9	D012509		HP:0030448	At least threefold overexpression of one of miR-206,-381, and 671-5p  was detected in all MPNSTs, EMCSs, SSs and 7 MCs.
tissue_expression_up	hsa-mir-381	Soft Tissue Sarcoma	27223121			C49.9	D012509		HP:0030448	At least threefold overexpression of one of miR-206,-381, and 671-5p  was detected in all MPNSTs, EMCSs, SSs and 7 MCs.
tissue_expression_up	hsa-mir-671	Soft Tissue Sarcoma	27223121			C49.9	D012509		HP:0030448	At least threefold overexpression of one of miR-206,-381, and 671-5p  was detected in all MPNSTs, EMCSs, SSs and 7 MCs.
tissue_expression_up	hsa-mir-140	Spinal Chordoma	25197358	musculoskeletal system disease	DOID:4153		D002817			Over-expression of miR-140-3p is correlated with recurrence and tumor invasion, suggesting that miR-140-3p could be a new predictor for recurrence and prognosis in patients with spinal chordoma.
tissue_expression_up	hsa-let-7a-1	Spinal Cord Injuries	20816819			S34.139A	D013119			Let-7a:SCI results in increased expression of miR Let-7a and miR16
tissue_expression_up	hsa-let-7a-2	Spinal Cord Injuries	20816819			S34.139A	D013119			Let-7a:SCI results in increased expression of miR Let-7a and miR16
tissue_expression_up	hsa-let-7a-3	Spinal Cord Injuries	20816819			S34.139A	D013119			Let-7a:SCI results in increased expression of miR Let-7a and miR16
tissue_expression_up	hsa-mir-15b	Spinal Cord Injuries	20816819			S34.139A	D013119			spinal cord injury (SCI)results in increased expression of miR Let-7a and miR16 while exercise leads to elevated levels of miR21 and decreased levels of miR15b. These changes in miR expression are correlated with changes in expression of their target genes: pro-apoptotic (decreased PTEN, PDCD4, and RAS mRNA) and anti-apoptotic (increased Bcl-2 mRNA) target genes. This is accompanied by a down-regulation of mRNA for caspase-7 and caspase-9 and reduced levels of caspase-7 protein.
tissue_expression_up	hsa-mir-16-1	Spinal Cord Injuries	20816819			S34.139A	D013119			miR16:SCI results in increased expression of miR Let-7a and miR16
tissue_expression_up	hsa-mir-16-2	Spinal Cord Injuries	20816819			S34.139A	D013119			miR16:SCI results in increased expression of miR Let-7a and miR16
tissue_expression_up	hsa-mir-21	Spinal Cord Injuries	26323253			S34.139A	D013119			miR鈥?46a, miR鈥?1 and miR鈥?50 expression was upregulated during H2O2 treatment.
tissue_expression_up	hsa-mir-192	Squamous Cell Carcinoma	19789312	disease of cellular proliferation	DOID:1749		D002294			In adenocarcinoma patients, miR-21, miR-223, miR-192, and miR-194 expression was elevated, whereas miR-203 expression was reduced in cancerous compared with noncancerous tissue.
tissue_expression_up	hsa-mir-194	Squamous Cell Carcinoma	19789312	disease of cellular proliferation	DOID:1749		D002294			In adenocarcinoma patients, miR-21, miR-223, miR-192, and miR-194 expression was elevated, whereas miR-203 expression was reduced in cancerous compared with noncancerous tissue.
tissue_expression_up	hsa-mir-21	Squamous Cell Carcinoma	19789312	disease of cellular proliferation	DOID:1749		D002294			In adenocarcinoma patients, miR-21, miR-223, miR-192, and miR-194 expression was elevated, whereas miR-203 expression was reduced in cancerous compared with noncancerous tissue.
tissue_expression_up	hsa-mir-223	Squamous Cell Carcinoma	19789312	disease of cellular proliferation	DOID:1749		D002294			In adenocarcinoma patients, miR-21, miR-223, miR-192, and miR-194 expression was elevated, whereas miR-203 expression was reduced in cancerous compared with noncancerous tissue.
tissue_expression_up	hsa-mir-33	Squamous Cell Carcinoma	20652977	disease of cellular proliferation	DOID:1749		D002294			The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes.
tissue_expression_up	hsa-mir-363	Squamous Cell Carcinoma	20652977	disease of cellular proliferation	DOID:1749		D002294			The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes.
tissue_expression_up	hsa-mir-497	Squamous Cell Carcinoma	20652977	disease of cellular proliferation	DOID:1749		D002294			The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes.
tissue_expression_up	hsa-mir-31	Squamous Cell Carcinoma, Cerevial	21590768	endocrine system disease	DOID:5531					miR-31 up-regulation in Drosha-overexpressing samples/cell lines was the highest-ranked change (by adjusted p value) in both analyses, an observation validated by northern blotting.
tissue_expression_up	hsa-mir-142	Squamous Cell Carcinoma, Esophageal	21882196	disease of cellular proliferation	DOID:3748		C562729			MiR-31 and miR-142-3p expression were correlated to histological differentiation in ESCC (P<0.05, Student's t-test); high miR-142-3p expression was associated with a poor prognosis in all 91 ESCC patients (P=0.014, log-rank) and identified as an independent prognostic factor in ESCC (P=0.017, univariate Cox; P=0.022, multivariate Cox). More importantly, stratified analysis indicated that high miR-142-3p expression was correlated to a poor prognosis within good-prognosis groups comprised of ESCC patients with small tumor size, negative lymph node metastasis, or early stage (all P<0.05).
tissue_expression_up	hsa-mir-205	Squamous Cell Carcinoma, Esophageal	20428818	disease of cellular proliferation	DOID:3748		C562729			miR-205:miR-205 and miR-21 are specific markers for HNSCC and ESCC
tissue_expression_up	hsa-mir-21	Squamous Cell Carcinoma, Esophageal	21883657	disease of cellular proliferation	DOID:3748		C562729			miR-21 expression was significantly up-regulated in the whole spectrum of preneoplastic/neoplastic lesions considered.
tissue_expression_up	hsa-mir-21	Squamous Cell Carcinoma, Esophageal	20428818	disease of cellular proliferation	DOID:3748		C562729			miR-21:miR-205 and miR-21 are specific markers for HNSCC and ESCC
tissue_expression_up	hsa-mir-210	Squamous Cell Carcinoma, Esophageal	26851030	disease of cellular proliferation	DOID:3748		C562729			squamous cell carcinoma (9.26-fold, p<0.001) and adenocarcinoma cell lines (4.95-fold, p<0.001) and miR-27a-star was significantly up-regulated in adenocarcinoma cell lines (4.79-fold, p=0.04).
tissue_expression_up	hsa-mir-296	Squamous Cell Carcinoma, Esophageal	20485139	disease of cellular proliferation	DOID:3748		C562729			miR-296:MiR-296 might play important roles in the pathogenesis of esophageal cancer and considered as a potential target for this malignancy intervention
tissue_expression_up	hsa-mir-30a	Squamous Cell Carcinoma, Esophageal	19536617	disease of cellular proliferation	DOID:3748		C562729			high expression levels; might play a important role in the development of the cancer
tissue_expression_up	hsa-mir-31	Squamous Cell Carcinoma, Esophageal	21658006	disease of cellular proliferation	DOID:3748		C562729			miR-31 was up-regulated in 77.8% of the ESCC tissues. Serum miR-31 levels in ESCC patients were significantly higher than in normal controls (P<0.001).
tissue_expression_up	hsa-mir-31	Squamous Cell Carcinoma, Esophageal	21882196	disease of cellular proliferation	DOID:3748		C562729			MiR-31 and miR-142-3p expression were correlated to histological differentiation in ESCC (P<0.05, Student's t-test); high miR-142-3p expression was associated with a poor prognosis in all 91 ESCC patients (P=0.014, log-rank) and identified as an independent prognostic factor in ESCC (P=0.017, univariate Cox; P=0.022, multivariate Cox). More importantly, stratified analysis indicated that high miR-142-3p expression was correlated to a poor prognosis within good-prognosis groups comprised of ESCC patients with small tumor size, negative lymph node metastasis, or early stage (all P<0.05).
tissue_expression_up	hsa-mir-373	Squamous Cell Carcinoma, Esophageal	29578163	disease of cellular proliferation	DOID:3748		C562729			Upregulation of miR-371-373 cluster, a human embryonic stem cell specific microRNA cluster, in esophageal squamous cell carcinoma
tissue_expression_up	hsa-mir-655	Squamous Cell Carcinoma, Esophageal	24314023	disease of cellular proliferation	DOID:3748		C562729			Mir-655 up-regulation suppresses cell invasion by targeting pituitary tumor-transforming gene-1 in esophageal squamous cell carcinoma.
tissue_expression_up	hsa-let-7a	Squamous Cell Carcinoma, Head and Neck	25862914	disease of cellular proliferation	DOID:5520	C76.0	C535575			The microRNA profile seems to play a potential role in the pathobiology of oropharyngeal and laryngeal HNSCC. Up-regulation of miR34a in p16-positive oropharyngeal cancer has not been so far described and additional studies are warranted.
tissue_expression_up	hsa-let-7i	Squamous Cell Carcinoma, Head and Neck	20145181	disease of cellular proliferation	DOID:5520	C76.0	C535575			overexpression
tissue_expression_up	hsa-mir-101-1	Squamous Cell Carcinoma, Head and Neck	21560177	disease of cellular proliferation	DOID:5520	C76.0	C535575			Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_up	hsa-mir-101-2	Squamous Cell Carcinoma, Head and Neck	21560177	disease of cellular proliferation	DOID:5520	C76.0	C535575			Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_up	hsa-mir-106b	Squamous Cell Carcinoma, Head and Neck	20145181	disease of cellular proliferation	DOID:5520	C76.0	C535575			Upregulation
tissue_expression_up	hsa-mir-125b	Squamous Cell Carcinoma, Head and Neck	29667275	disease of cellular proliferation	DOID:5520	C76.0	C535575			miR-26 and miR-125b may be associated with the progression and metastasis of HNSCC, and that miR-203 is associated with a more favourable prognosis.
tissue_expression_up	hsa-mir-142	Squamous Cell Carcinoma, Head and Neck	20145181	disease of cellular proliferation	DOID:5520	C76.0	C535575			miR-142-3p; overexpression
tissue_expression_up	hsa-mir-155	Squamous Cell Carcinoma, Head and Neck	20145181	disease of cellular proliferation	DOID:5520	C76.0	C535575			overexpression
tissue_expression_up	hsa-mir-181b-1	Squamous Cell Carcinoma, Head and Neck	21560177	disease of cellular proliferation	DOID:5520	C76.0	C535575			Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_up	hsa-mir-181b-2	Squamous Cell Carcinoma, Head and Neck	21560177	disease of cellular proliferation	DOID:5520	C76.0	C535575			Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_up	hsa-mir-181d	Squamous Cell Carcinoma, Head and Neck	21560177	disease of cellular proliferation	DOID:5520	C76.0	C535575			Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_up	hsa-mir-195	Squamous Cell Carcinoma, Head and Neck	21560177	disease of cellular proliferation	DOID:5520	C76.0	C535575			Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01).
tissue_expression_up	hsa-mir-200c	Squamous Cell Carcinoma, Head and Neck	25862914	disease of cellular proliferation	DOID:5520	C76.0	C535575			The microRNA profile seems to play a potential role in the pathobiology of oropharyngeal and laryngeal HNSCC. Up-regulation of miR34a in p16-positive oropharyngeal cancer has not been so far described and additional studies are warranted.
tissue_expression_up	hsa-mir-205	Squamous Cell Carcinoma, Head and Neck	20428818	disease of cellular proliferation	DOID:5520	C76.0	C535575			miR-205:miR-205 and miR-21 are specific markers for HNSCC and ESCC
tissue_expression_up	hsa-mir-20a	Squamous Cell Carcinoma, Head and Neck	20145181	disease of cellular proliferation	DOID:5520	C76.0	C535575			Upregulation
tissue_expression_up	hsa-mir-21	Squamous Cell Carcinoma, Head and Neck	20145181	disease of cellular proliferation	DOID:5520	C76.0	C535575			overexpression
tissue_expression_up	hsa-mir-21	Squamous Cell Carcinoma, Head and Neck	20428818	disease of cellular proliferation	DOID:5520	C76.0	C535575			miR-21:miR-205 and miR-21 are specific markers for HNSCC and ESCC
tissue_expression_up	hsa-mir-21	Squamous Cell Carcinoma, Head and Neck	25862914	disease of cellular proliferation	DOID:5520	C76.0	C535575			The microRNA profile seems to play a potential role in the pathobiology of oropharyngeal and laryngeal HNSCC. Up-regulation of miR34a in p16-positive oropharyngeal cancer has not been so far described and additional studies are warranted.
tissue_expression_up	hsa-mir-26	Squamous Cell Carcinoma, Head and Neck	29667275	disease of cellular proliferation	DOID:5520	C76.0	C535575			miR-26 and miR-125b may be associated with the progression and metastasis of HNSCC, and that miR-203 is associated with a more favourable prognosis.
tissue_expression_up	hsa-mir-34a	Squamous Cell Carcinoma, Head and Neck	25862914	disease of cellular proliferation	DOID:5520	C76.0	C535575			The microRNA profile seems to play a potential role in the pathobiology of oropharyngeal and laryngeal HNSCC. Up-regulation of miR34a in p16-positive oropharyngeal cancer has not been so far described and additional studies are warranted.
tissue_expression_up	hsa-mir-375	Squamous Cell Carcinoma, Head and Neck	25862914	disease of cellular proliferation	DOID:5520	C76.0	C535575			The microRNA profile seems to play a potential role in the pathobiology of oropharyngeal and laryngeal HNSCC. Up-regulation of miR34a in p16-positive oropharyngeal cancer has not been so far described and additional studies are warranted.
tissue_expression_up	hsa-mir-423	Squamous Cell Carcinoma, Head and Neck	20145181	disease of cellular proliferation	DOID:5520	C76.0	C535575			Upregulation
tissue_expression_up	hsa-mir-155	Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal	26847279	disease of cellular proliferation	DOID:2876					The expression of tissue and plasma miR-155 were significantly up-regulated in patients with LSCC. Our work will serve as a basis for further investigation, preferably large-scale validation in clinical trials.
tissue_expression_up	hsa-mir-15a	Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal	26497405	disease of cellular proliferation	DOID:2876					We detected miR-363 and miR-15a, and their expression levels were significantly increased in the HPV-16-positive patients and in FaDu cells expressing HPV-16 E6-E7.
tissue_expression_up	hsa-mir-21	Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal	22320969	disease of cellular proliferation	DOID:2876					Mir-21 was up-regulated in LSCCs (laryngeal squamous cell carcinomas) and HSCCs(hypopharyngeal squamous cell carcinomas) compared to adjacent non-tumor tissues (P < 0.05), and the up-regulated expression of mir-21 was associated with clinical stage (P = 0.001), T classification (P = 0.007), pathologic differentiation (P = 0.025), and lymph node positivity (P = 0.002).
tissue_expression_up	hsa-mir-375	Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal	27446362	disease of cellular proliferation	DOID:2876					The results of the present study suggested that miR-148a and miR-375 were significantly upregulated in LSCC tissues, and increased expression of miR-375 was associated with a more aggressive phenotype of LSCC.
tissue_expression_up	hsa-mir-125a	Squamous Cell Carcinoma, Lung	20620595	disease of cellular proliferation	DOID:3907	C34.91				miR-125a-5p:The miRNAs miR-185 * and miR-125a-5p were significantly upregulated in lung SCC
tissue_expression_up	hsa-mir-185	Squamous Cell Carcinoma, Lung	20620595	disease of cellular proliferation	DOID:3907	C34.91				miR-185:The miRNAs miR-185 * and miR-125a-5p were significantly upregulated in lung SCC
tissue_expression_up	hsa-mir-1246	Squamous Cell Carcinoma, Oral	25791131	disease of cellular proliferation	DOID:0050866					High miR-1246 expression is associated with poor prognosis in OSCC and may serve as a novel prognostic marker in OSCC.
tissue_expression_up	hsa-mir-129-1	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-129-2	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-138	Squamous Cell Carcinoma, Oral	26841253	disease of cellular proliferation	DOID:0050866					Upregulation of miR-138 and miR-183 was observed in 50.0% of the samples
tissue_expression_up	hsa-mir-142	Squamous Cell Carcinoma, Oral	27056547	disease of cellular proliferation	DOID:0050866					let-7a, let-7d, let-7f and miR-16 were downregulated while miR-29b, miR-142-3p, miR-144, miR-203, and miR-223 were upregulated in OSCC
tissue_expression_up	hsa-mir-144	Squamous Cell Carcinoma, Oral	27056547	disease of cellular proliferation	DOID:0050866					let-7a, let-7d, let-7f and miR-16 were downregulated while miR-29b, miR-142-3p, miR-144, miR-203, and miR-223 were upregulated in OSCC
tissue_expression_up	hsa-mir-146b	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-155	Squamous Cell Carcinoma, Oral	24439918	disease of cellular proliferation	DOID:0050866					In OSSC, upregulation of miR-155 correlated with the histologic grade and can be used as a potential prognostic biomarker.
tissue_expression_up	hsa-mir-155	Squamous Cell Carcinoma, Oral	24692283	disease of cellular proliferation	DOID:0050866					MiRNA-155 was overexpressed in OSCC and it was located in the cancer nest, inflammatory area, and vascular endothelium of OSCC. High miRNA-155 expression level in ACF may predict poor prognosis in patients with OSCC.
tissue_expression_up	hsa-mir-181b	Squamous Cell Carcinoma, Oral	27509922	disease of cellular proliferation	DOID:0050866					he expression levels of miR鈥?81b and Bcl鈥? in OVC were significantly higher compared with normal mucosal tissue (NM);
tissue_expression_up	hsa-mir-183	Squamous Cell Carcinoma, Oral	26841253	disease of cellular proliferation	DOID:0050866					Upregulation of miR-138 and miR-183 was observed in 50.0% of the samples
tissue_expression_up	hsa-mir-203	Squamous Cell Carcinoma, Oral	27056547	disease of cellular proliferation	DOID:0050866					let-7a, let-7d, let-7f and miR-16 were downregulated while miR-29b, miR-142-3p, miR-144, miR-203, and miR-223 were upregulated in OSCC
tissue_expression_up	hsa-mir-205	Squamous Cell Carcinoma, Oral	26841253	disease of cellular proliferation	DOID:0050866					Upregulation of miR-138, miRNA-145, and miR-205 was associated with advanced tumor stages, vascular invasion, and lymph node metastasis, respectively.
tissue_expression_up	hsa-mir-21	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-21	Squamous Cell Carcinoma, Oral	25482863	disease of cellular proliferation	DOID:0050866					Our results corroborate the previous findings on the overexpression  of mir-21 and downregulation of miR-138 in OSCC. As the expression of miR-184 is controversial in tongue/oral cancer, the downregulation may be specific to tumor anatomical localization. On the other hand, to the best of our knowledge, this is the first report to show the association of miR-155 with tobacco chewing and the downregulation of miR-125b-2* in OSCC. Computational predictions suggest that miR-125b-2* may have a role in alternative splicing.
tissue_expression_up	hsa-mir-21	Squamous Cell Carcinoma, Oral	29480379	disease of cellular proliferation	DOID:0050866					increased miR-21 levels in conjunction with decreased miR-125a levels in saliva of OLP patients may be indicative for a poor prognosis
tissue_expression_up	hsa-mir-210	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-212	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-214	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-223	Squamous Cell Carcinoma, Oral	27056547	disease of cellular proliferation	DOID:0050866					let-7a, let-7d, let-7f and miR-16 were downregulated while miR-29b, miR-142-3p, miR-144, miR-203, and miR-223 were upregulated in OSCC
tissue_expression_up	hsa-mir-23a	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-23b	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-25	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-29b	Squamous Cell Carcinoma, Oral	27056547	disease of cellular proliferation	DOID:0050866					let-7a, let-7d, let-7f and miR-16 were downregulated while miR-29b, miR-142-3p, miR-144, miR-203, and miR-223 were upregulated in OSCC
tissue_expression_up	hsa-mir-30b	Squamous Cell Carcinoma, Oral	22542163	disease of cellular proliferation	DOID:0050866					Amplification and up-regulation of microRNA-30b in oral squamous cell cancers.
tissue_expression_up	hsa-mir-31	Squamous Cell Carcinoma, Oral	24238414	disease of cellular proliferation	DOID:0050866					The up-regulated level of microRNA-31 expression may be related to the pathogenesis of OSCC.
tissue_expression_up	hsa-mir-338	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-489	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-515-1	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-515-2	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-92a-1	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-92a-2	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-92b	Squamous Cell Carcinoma, Oral	21244772	disease of cellular proliferation	DOID:0050866					Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours.
tissue_expression_up	hsa-mir-92b	Squamous Cell Carcinoma, Oral	26503628	disease of cellular proliferation	DOID:0050866					Taken together, our results indicate that miR-92b upregulation accelerates tumor growth and present a novel mechanism of miRNA-mediated NF-κB activation in OSCC.
tissue_expression_up	hsa-mir-124	Squamous Cell Carcinoma, Skin or Unspecific	27818465	disease of cellular proliferation	DOID:3151	C44.92			HP:0006739	The expression of miR-124 increases in aged skin to cause cell senescence and it decreases in squamous cell carcinoma.
tissue_expression_up	hsa-mir-135b	Squamous Cell Carcinoma, Skin or Unspecific	23026055	disease of cellular proliferation	DOID:3151	C44.92			HP:0006739	Non-stringent filtering with a non-adjusted p ≤ 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC
tissue_expression_up	hsa-mir-424	Squamous Cell Carcinoma, Skin or Unspecific	23026055	disease of cellular proliferation	DOID:3151	C44.92			HP:0006739	Non-stringent filtering with a non-adjusted p ≤ 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC
tissue_expression_up	hsa-mir-766	Squamous Cell Carcinoma, Skin or Unspecific	23026055	disease of cellular proliferation	DOID:3151	C44.92			HP:0006739	Non-stringent filtering with a non-adjusted p ≤ 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC
tissue_expression_up	hsa-mir-124	Stroke	23826665			I64	D020521	601367	HP:0001297	The level of miR-124 is significantly increased in ischemic penumbra as compared with that in nonischemic area of MACO mice.
tissue_expression_up	hsa-mir-146a	Stroke	26738853			I64	D020521	601367	HP:0001297	stroke considerably increased miR-146a density in the corpus callosum and subventricular zone (SVZ) of the lateral ventricle of the ischemic hemisphere.
tissue_expression_up	hsa-mir-155	Stroke	29642385			I64	D020521	601367	HP:0001297	Exposure to the high dose of CS also significantly upregulated the miRNA-155 level in the aortic tissues of ApoE KO mice
tissue_expression_up	hsa-mir-17	Stroke	23511639			I64	D020521	601367	HP:0001297	These data indicate that the miR17-92 cluster plays an important role in mediating neural progenitor cell function and that the Shh signaling pathway is involved in up-regulating miR17-92 cluster expression.
tissue_expression_up	hsa-mir-18	Stroke	23511639			I64	D020521	601367	HP:0001297	These data indicate that the miR17-92 cluster plays an important role in mediating neural progenitor cell function and that the Shh signaling pathway is involved in up-regulating miR17-92 cluster expression.
tissue_expression_up	hsa-mir-19a	Stroke	23511639			I64	D020521	601367	HP:0001297	These data indicate that the miR17-92 cluster plays an important role in mediating neural progenitor cell function and that the Shh signaling pathway is involved in up-regulating miR17-92 cluster expression.
tissue_expression_up	hsa-mir-19b-1	Stroke	23511639			I64	D020521	601367	HP:0001297	These data indicate that the miR17-92 cluster plays an important role in mediating neural progenitor cell function and that the Shh signaling pathway is involved in up-regulating miR17-92 cluster expression.
tissue_expression_up	hsa-mir-20a	Stroke	23511639			I64	D020521	601367	HP:0001297	These data indicate that the miR17-92 cluster plays an important role in mediating neural progenitor cell function and that the Shh signaling pathway is involved in up-regulating miR17-92 cluster expression.
tissue_expression_up	hsa-mir-21	Stroke	29642385			I64	D020521	601367	HP:0001297	Moreover, the expression level of miR-126 tended to be downregulated and that of miR-21 tended to be upregulated in ApoE KO mice exposed to the high dose of CS, albeit statistically insignificant
tissue_expression_up	hsa-mir-92-1	Stroke	23511639			I64	D020521	601367	HP:0001297	These data indicate that the miR17-92 cluster plays an important role in mediating neural progenitor cell function and that the Shh signaling pathway is involved in up-regulating miR17-92 cluster expression.
tissue_expression_up	hsa-mir-34a	Stroke, Ischemic	27545688			I63.9			HP:0002140	Increased Expression of mir-34a-5p and Clinical Association in Acute Ischemic Stroke Patients and in a Rat Model.
tissue_expression_up	hsa-mir-9	Stroke, Ischemic	26718002			I63.9			HP:0002140	The expression of miR-9 in the peri-infarct cortex was increased in the EA group compared with the MCAO group
tissue_expression_up	hsa-let-7e	Synovial Sarcoma	21213367	disease of cellular proliferation	DOID:5485		D013584	300813	HP:0012570	upregulated
tissue_expression_up	hsa-mir-125a	Synovial Sarcoma	21213367	disease of cellular proliferation	DOID:5485		D013584	300813	HP:0012570	hsa-mir-125a-3p upregulated
tissue_expression_up	hsa-mir-99b	Synovial Sarcoma	21213367	disease of cellular proliferation	DOID:5485		D013584	300813	HP:0012570	upregulated
tissue_expression_up	hsa-mir-146a	Systemic Lupus Erythematosus	21987229	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	The levels of urinary miR-146a and miR-155 in patients with SLE were significantly higher than that in healthy controls. Calcitriol treatment reduced the levels of urinary miR-155 in patients with SLE. The level of urinary miR-146a significantly correlated with estimated glomerular filtration rate. The level of urinary miR-155 significantly correlated with proteinuria  and systemic lupus erythematosus disease activity index (r=0.278, P=0.002). The level of urinary miR-146a reversely correlated with the urinary expression of TNF-a. Our results suggested that miR-146a and miR-155 might play important roles in the pathophysiology of SLE and the levels of urinary miR-146a and miR-155 could be used as potential markers for diagnosis, disease activity, and therapeutic response.
tissue_expression_up	hsa-mir-146a	Systemic Lupus Erythematosus	26315540	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	Type I IFN inhibits the maturation of miR-146a through the up-regulation of MCPIP-1, and thus contributes to the uncontrolled inflammation and excessive inflammatory gene expression in SLE.
tissue_expression_up	hsa-mir-155	Systemic Lupus Erythematosus	21987229	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	The levels of urinary miR-146a and miR-155 in patients with SLE were significantly higher than that in healthy controls. Calcitriol treatment reduced the levels of urinary miR-155 in patients with SLE. The level of urinary miR-146a significantly correlated with estimated glomerular filtration rate. The level of urinary miR-155 significantly correlated with proteinuria  and systemic lupus erythematosus disease activity index (r=0.278, P=0.002). The level of urinary miR-146a reversely correlated with the urinary expression of TNF-a. Our results suggested that miR-146a and miR-155 might play important roles in the pathophysiology of SLE and the levels of urinary miR-146a and miR-155 could be used as potential markers for diagnosis, disease activity, and therapeutic response.
tissue_expression_up	hsa-mir-155	Systemic Lupus Erythematosus	28779021	musculoskeletal system disease	DOID:9074	M32.9	D008180	152700	HP:0002725	IFN-α impairs insulin-mediated NO production, and altered gene expression resulted from eNOS instability, possibly due to enhanced miR-155 expression
tissue_expression_up	hsa-mir-629	Testicular Neoplasms	19946373	disease of cellular proliferation	DOID:2998		D013736	273300	HP:0010788	upregulated
tissue_expression_up	hsa-mir-100	Thyroid Neoplasms	22006248	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-100, miR-125b, miR-138, and miR-768-3p were overexpressed in malignant samples of follicular origin (P <0.001), and in Hurthle cell carcinoma samples alone (P < 0.01). Only miR-125b was significantly overexpressed in follicular carcinoma samples (P < .05).
tissue_expression_up	hsa-mir-10b	Thyroid Neoplasms	23563786	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	The miR-221/222 cluster, miR-10b and miR-92a are highly upregulated in metastatic minimally invasive follicular thyroid carcinoma
tissue_expression_up	hsa-mir-122	Thyroid Neoplasms	21779480	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	The miRNA increased 8.9-fold (P < 0.05) in all Thyroid Neoplasms versus normal.
tissue_expression_up	hsa-mir-125b-1	Thyroid Neoplasms	22006248	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-100, miR-125b, miR-138, and miR-768-3p were overexpressed in malignant samples of follicular origin (P < .001), and in Hurthle cell carcinoma samples alone (P < .01). Only miR-125b was significantly overexpressed in follicular carcinoma samples (P < .05).
tissue_expression_up	hsa-mir-125b-2	Thyroid Neoplasms	22006248	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-100, miR-125b, miR-138, and miR-768-3p were overexpressed in malignant samples of follicular origin (P < .001), and in Hurthle cell carcinoma samples alone (P < .01). Only miR-125b was significantly overexpressed in follicular carcinoma samples (P < .05).
tissue_expression_up	hsa-mir-126	Thyroid Neoplasms	21553140	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-7 and miR-126 could be candidate diagnostic microRNAs for thyroid histologic subtypes.
tissue_expression_up	hsa-mir-127	Thyroid Neoplasms	22747440	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001).
tissue_expression_up	hsa-mir-138-1	Thyroid Neoplasms	22006248	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-100, miR-125b, miR-138, and miR-768-3p were overexpressed in malignant samples of follicular origin (P < .001), and in Hurthle cell carcinoma samples alone (P < .01). Only miR-125b was significantly overexpressed in follicular carcinoma samples (P < .05).
tissue_expression_up	hsa-mir-138-2	Thyroid Neoplasms	22006248	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-100, miR-125b, miR-138, and miR-768-3p were overexpressed in malignant samples of follicular origin (P < .001), and in Hurthle cell carcinoma samples alone (P < .01). Only miR-125b was significantly overexpressed in follicular carcinoma samples (P < .05).
tissue_expression_up	hsa-mir-146b	Thyroid Neoplasms	18587330	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-146b: overexpressed
tissue_expression_up	hsa-mir-146b	Thyroid Neoplasms	21537871	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC.
tissue_expression_up	hsa-mir-154	Thyroid Neoplasms	22747440	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001).
tissue_expression_up	hsa-mir-155	Thyroid Neoplasms	21537871	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC.
tissue_expression_up	hsa-mir-183	Thyroid Neoplasms	22747440	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001).
tissue_expression_up	hsa-mir-21	Thyroid Neoplasms	22747440	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001).
tissue_expression_up	hsa-mir-21	Thyroid Neoplasms	23416953	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	there were significant associations (P<0.05) between BRAF(V600E) and a higher tumor-node-metastasis staging (III/IV), and between miR-21* over-expression and lymph node metastasis.
tissue_expression_up	hsa-mir-221	Thyroid Neoplasms	17028596	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	Upregulated mir-221/222 in papillary thyroid cancer
tissue_expression_up	hsa-mir-221	Thyroid Neoplasms	18587330	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-221: overexpressed
tissue_expression_up	hsa-mir-221	Thyroid Neoplasms	21275764	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	mir-221 was overexpressed in 19 patients (p<0.0001) with a sensitive yield of 95%.
tissue_expression_up	hsa-mir-221	Thyroid Neoplasms	21537871	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC.
tissue_expression_up	hsa-mir-221	Thyroid Neoplasms	23563786	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	The miR-221/222 cluster, miR-10b and miR-92a are highly upregulated in metastatic minimally invasive follicular thyroid carcinoma
tissue_expression_up	hsa-mir-222	Thyroid Neoplasms	17028596	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	Upregulated mir-221/222 in papillary thyroid cancer
tissue_expression_up	hsa-mir-222	Thyroid Neoplasms	18587330	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-222: overexpressed
tissue_expression_up	hsa-mir-222	Thyroid Neoplasms	21537871	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC.
tissue_expression_up	hsa-mir-222	Thyroid Neoplasms	23563786	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	The miR-221/222 cluster, miR-10b and miR-92a are highly upregulated in metastatic minimally invasive follicular thyroid carcinoma
tissue_expression_up	hsa-mir-222	Thyroid Neoplasms	27353001	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-25 and miR-222 expression was upregulated in 8505C
tissue_expression_up	hsa-mir-222	Thyroid Neoplasms	26745212	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-221 and miR-222 are consistently upregulated in different types of thyroid carcinomas
tissue_expression_up	hsa-mir-224	Thyroid Neoplasms	22747440	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001).
tissue_expression_up	hsa-mir-25	Thyroid Neoplasms	27353001	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-25 and miR-222 expression was upregulated in 8505C
tissue_expression_up	hsa-mir-31	Thyroid Neoplasms	21537871	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC.
tissue_expression_up	hsa-mir-323	Thyroid Neoplasms	22747440	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001).
tissue_expression_up	hsa-mir-370	Thyroid Neoplasms	22747440	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001).
tissue_expression_up	hsa-mir-375	Thyroid Neoplasms	22747440	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001).
tissue_expression_up	hsa-mir-7-1	Thyroid Neoplasms	21553140	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-7 and miR-126 could be candidate diagnostic microRNAs for thyroid histologic subtypes.
tissue_expression_up	hsa-mir-7-2	Thyroid Neoplasms	21553140	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-7 and miR-126 could be candidate diagnostic microRNAs for thyroid histologic subtypes.
tissue_expression_up	hsa-mir-7-3	Thyroid Neoplasms	21553140	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	miR-7 and miR-126 could be candidate diagnostic microRNAs for thyroid histologic subtypes.
tissue_expression_up	hsa-mir-9	Thyroid Neoplasms	22747440	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001).
tissue_expression_up	hsa-mir-92a-1	Thyroid Neoplasms	23563786	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	The miR-221/222 cluster, miR-10b and miR-92a are highly upregulated in metastatic minimally invasive follicular thyroid carcinoma
tissue_expression_up	hsa-mir-92a-2	Thyroid Neoplasms	23563786	disease of cellular proliferation	DOID:1781	C73	D013964	188550	HP:0100031	The miR-221/222 cluster, miR-10b and miR-92a are highly upregulated in metastatic minimally invasive follicular thyroid carcinoma
tissue_expression_up	hsa-mir-22	Toxic Encephalopathy	26649298	nervous system disease	DOID:3602	G92	D020258			Our results demonstrated that PFOS exposure decreased miR-16 expression and increased miR-22 expression, which may represent a possible mechanism by which PFOS decreases BDNF protein levels. PFOS may inhibit BDNF-ERK-CREB signalling by increasing miR-22 levels, which may, in part, explain the mechanism of PFOS neurotoxicity.
tissue_expression_up	hsa-mir-106a	Toxoplasma gondii Infection	20423977	disease by infectious agent	DOID:9965	B58	D014123			hsa-mir-106a:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii
tissue_expression_up	hsa-mir-106b	Toxoplasma gondii Infection	20423977	disease by infectious agent	DOID:9965	B58	D014123			hsa-mir-106b:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii
tissue_expression_up	hsa-mir-17	Toxoplasma gondii Infection	20423977	disease by infectious agent	DOID:9965	B58	D014123			hsa-mir-17:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii
tissue_expression_up	hsa-mir-18a	Toxoplasma gondii Infection	20423977	disease by infectious agent	DOID:9965	B58	D014123			hsa-mir-18a:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii
tissue_expression_up	hsa-mir-18b	Toxoplasma gondii Infection	20423977	disease by infectious agent	DOID:9965	B58	D014123			hsa-mir-18b:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii
tissue_expression_up	hsa-mir-20a	Toxoplasma gondii Infection	20423977	disease by infectious agent	DOID:9965	B58	D014123			hsa-mir-20a:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii
tissue_expression_up	hsa-mir-20b	Toxoplasma gondii Infection	20423977	disease by infectious agent	DOID:9965	B58	D014123			hsa-mir-20b:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii
tissue_expression_up	hsa-mir-93	Toxoplasma gondii Infection	20423977	disease by infectious agent	DOID:9965	B58	D014123			hsa-mir-93:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii
tissue_expression_up	hsa-mir-424	Tuberculosis	22964481	disease by infectious agent	DOID:399	A15-A19	D014376			we observed that miR-146a expression is also down-regulated in tuberculosis patients, both in PBMCs and PFMCs while miR-424 levels are elevated only in the peripheral compartments.
tissue_expression_up	hsa-mir-147a	Tuberculosis, Pulmonary	22900099	disease by infectious agent	DOID:2957	A15	D014397			Overexpression
tissue_expression_up	hsa-mir-147b	Tuberculosis, Pulmonary	22900099	disease by infectious agent	DOID:2957	A15	D014397			Overexpression
tissue_expression_up	hsa-mir-3179-1	Tuberculosis, Pulmonary	22900099	disease by infectious agent	DOID:2957	A15	D014397			Overexpression
tissue_expression_up	hsa-mir-3179-2	Tuberculosis, Pulmonary	22900099	disease by infectious agent	DOID:2957	A15	D014397			Overexpression
tissue_expression_up	hsa-mir-3179-3	Tuberculosis, Pulmonary	22900099	disease by infectious agent	DOID:2957	A15	D014397			Overexpression
tissue_expression_up	hsa-mir-141	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, upregulated.
tissue_expression_up	hsa-mir-141	Urinary Bladder Cancer	22886973	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated.
tissue_expression_up	hsa-mir-145	Urinary Bladder Cancer	26514209	urinary system disease	DOID:11054	C67	D001749	109800		Results indicate that miR-145 suppresses syndecan-1 and, by this mechanism, up-regulates stem cell factors and induces cell senescence and differentiation. We propose that miR-145 may confer stem cell-like properties on urothelial carcinoma cells and thus facilitate differentiation into multiple cell types.
tissue_expression_up	hsa-mir-146a	Urinary Bladder Cancer	18596939	urinary system disease	DOID:11054	C67	D001749	109800		miR-146a: upregulated
tissue_expression_up	hsa-mir-155	Urinary Bladder Cancer	22386240	urinary system disease	DOID:11054	C67	D001749	109800		Compared with controls, the patients with bladder cancer had a lower expression of the miR-200 family, miR-192, and miR-155 in the urinary sediment; lower expression of miR-192; and higher expression of miR-155 in the urinary supernatant.
tissue_expression_up	hsa-mir-155	Urinary Bladder Cancer	18596939	urinary system disease	DOID:11054	C67	D001749	109800		miR-155: upregulated
tissue_expression_up	hsa-mir-15b	Urinary Bladder Cancer	18596939	urinary system disease	DOID:11054	C67	D001749	109800		miR-15b: upregulated
tissue_expression_up	hsa-mir-16-1	Urinary Bladder Cancer	18596939	urinary system disease	DOID:11054	C67	D001749	109800		miR-16: upregulated
tissue_expression_up	hsa-mir-16-2	Urinary Bladder Cancer	18596939	urinary system disease	DOID:11054	C67	D001749	109800		miR-16: upregulated
tissue_expression_up	hsa-mir-17	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, upregulated.
tissue_expression_up	hsa-mir-183	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, upregulated.
tissue_expression_up	hsa-mir-18a	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, upregulated.
tissue_expression_up	hsa-mir-19a	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, upregulated.
tissue_expression_up	hsa-mir-19b-1	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, upregulated.
tissue_expression_up	hsa-mir-19b-2	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, upregulated.
tissue_expression_up	hsa-mir-200a	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, upregulated.
tissue_expression_up	hsa-mir-200a	Urinary Bladder Cancer	22886973	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated.
tissue_expression_up	hsa-mir-200b	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, upregulated.
tissue_expression_up	hsa-mir-200c	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, upregulated.
tissue_expression_up	hsa-mir-200c	Urinary Bladder Cancer	22886973	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated.
tissue_expression_up	hsa-mir-20a	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, upregulated.
tissue_expression_up	hsa-mir-21	Urinary Bladder Cancer	22133680	urinary system disease	DOID:11054	C67	D001749	109800		Nuclear and cytoplasmatic PDCD4 immunostaining decreased significantly with histopathological progression of the tumor (p<0001). Controls showed strong nuclear and cytoplasmatic immunohistochemical staining. MiR-21 up regulation in tissue corresponded to PDCD4 suppression.
tissue_expression_up	hsa-mir-21	Urinary Bladder Cancer	22704449	urinary system disease	DOID:11054	C67	D001749	109800		High miR-21 expression correlated with worse overall patient survival (p = 0.0099).
tissue_expression_up	hsa-mir-21	Urinary Bladder Cancer	22194833	urinary system disease	DOID:11054	C67	D001749	109800		mir-21 expression increased with worsening clinical diagnosis but that mir-143 was not correlated with histology. These observations were in stark contrast to previous reports involving cervical cancer cell lines in which mir-143 was consistently down-regulated but mir-21 largely unaffected.
tissue_expression_up	hsa-mir-29b-1	Urinary Bladder Cancer	21223810	urinary system disease	DOID:11054	C67	D001749	109800		In grade I, grade II, grade III, grade I + II + III, infiltrating and non-infiltrating groups, hsa-miR-29b-1* was up-regulated while hsa-miR-923 and hsa-miR-300 were down-regulated
tissue_expression_up	hsa-mir-29c	Urinary Bladder Cancer	22886973	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated.
tissue_expression_up	hsa-mir-378a	Urinary Bladder Cancer	22886973	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated.
tissue_expression_up	hsa-mir-378b	Urinary Bladder Cancer	22886973	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated.
tissue_expression_up	hsa-mir-378c	Urinary Bladder Cancer	22886973	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated.
tissue_expression_up	hsa-mir-378d-1	Urinary Bladder Cancer	22886973	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated.
tissue_expression_up	hsa-mir-378d-2	Urinary Bladder Cancer	22886973	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated.
tissue_expression_up	hsa-mir-378e	Urinary Bladder Cancer	22886973	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated.
tissue_expression_up	hsa-mir-378f	Urinary Bladder Cancer	22886973	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated.
tissue_expression_up	hsa-mir-378g	Urinary Bladder Cancer	22886973	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated.
tissue_expression_up	hsa-mir-378h	Urinary Bladder Cancer	22886973	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated.
tissue_expression_up	hsa-mir-378i	Urinary Bladder Cancer	22886973	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated.
tissue_expression_up	hsa-mir-424	Urinary Bladder Cancer	22469983	urinary system disease	DOID:11054	C67	D001749	109800		Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer.
tissue_expression_up	hsa-mir-429	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, upregulated.
tissue_expression_up	hsa-mir-429	Urinary Bladder Cancer	22886973	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated.
tissue_expression_up	hsa-mir-92a-1	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, upregulated.
tissue_expression_up	hsa-mir-92a-2	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, upregulated.
tissue_expression_up	hsa-mir-96	Urinary Bladder Cancer	21464941	urinary system disease	DOID:11054	C67	D001749	109800		Compared to matched histologically normal urothelium, upregulated.
tissue_expression_up	hsa-mir-96	Urinary Bladder Cancer	21993544	urinary system disease	DOID:11054	C67	D001749	109800		hsa-mir-96 up-regulates MAP4K1 and IRS1 and may function as a promising diagnostic marker in human bladder urothelial carcinomas.
tissue_expression_up	hsa-mir-10a	Urinary System Cancer	29623292	disease of cellular proliferation	DOID:3996	C68.9				the decline of miR-145 expression level have been proved to be able to distinguish bladder cancer patients from non-cancer controls in cell-free urine samples5; the elevation of miR-10a and miR-30d was also observed in urine samples from patients with focal segmental glomerulosclerosis
tissue_expression_up	hsa-mir-30d	Urinary System Cancer	29623292	disease of cellular proliferation	DOID:3996	C68.9				the decline of miR-145 expression level have been proved to be able to distinguish bladder cancer patients from non-cancer controls in cell-free urine samples5; the elevation of miR-10a and miR-30d was also observed in urine samples from patients with focal segmental glomerulosclerosis
tissue_expression_up	hsa-mir-1298	Vascular Disease [unspecific]	26199195	cardiovascular system disease	DOID:178	I72.9	D000783			Keep calm and carry on: miR-1298 prevents up-regulation of Cx43 and secures a quiescent vascular smooth muscle cell.
tissue_expression_up	hsa-mir-126	Vasomotor Rhinitis	28787742	respiratory system disease	DOID:4730	J30.0	D012223			there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p.
tissue_expression_up	hsa-mir-129	Vasomotor Rhinitis	28787742	respiratory system disease	DOID:4730	J30.0	D012223			there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p.
tissue_expression_up	hsa-mir-543	Vasomotor Rhinitis	28787742	respiratory system disease	DOID:4730	J30.0	D012223			there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p.
tissue_expression_up	hsa-mir-155	Vitiligo	26941046	immune system disease	DOID:12306	L80	D014820		HP:0001045	miR-99b, miR-125b, miR-155 and miR-199a-3p were found to be increased and miR-145 was found to be decreased in the skin of patients with vitiligo.
tissue_expression_up	hsa-mir-590	Vulvar Squamous Cell Carcinoma	26498065	disease of cellular proliferation	DOID:2101					In conclusion, we present the miRNA expression profile in VSCC, and our findings suggest that the upregulation of miR-590-5p promotes cellular malignant behaviours via the target gene TGFβRII.
tissue_expression_up	hsa-mir-155	Waldenstrom Macroglobulinemia	23301642			C88.0	D008258	153600	HP:0005508	The most important changes of microRNA are increased expression of miR-155 and decreased expression of miR-9*. 
tissue_expression_up	hsa-mir-155	Waldenstrom Macroglobulinemia	25893290			C88.0	D008258	153600	HP:0005508	In two cell lines, miR-155 upregulation, which is common in WM, was responsible for the  inhibition of FOXO3a and Bim expression.