ID Species ncRNA ncRNA type Environmental factor (EF) Phenotype Sample Condition of EF Evidence PubMed ID 1 Human chr13:50054355-50057699 circRNA adriamycin (ADR) acute myeloid leukemia (AML) HL-60 cells adriamycin (ADR) treatment downregulated 31818729 2 Human chr13:50054355-50057699+ circRNA adriamycin (ADR) acute myeloid leukemia (AML) HL-60 cells adriamycin (ADR) treatment downregulated 31818729 3 Human chr14:101402109-101464448+ circRNA gemcitabine (GEM) pancreatic cancer (PC) PANC-1 cells gemcitabine (GEM) treatment chr14:101402109- 101464448+ was found significantly upregulated in non-responsive group. 29922161 4 Human chr18:21644104-21649235 circRNA adriamycin (ADR) acute myeloid leukemia (AML) HL-60 cells adriamycin (ADR) treatment downregulated 31818729 5 Human chr18:21644104-21649235+ circRNA adriamycin (ADR) acute myeloid leukemia (AML) HL-60 cells adriamycin (ADR) treatment downregulated 31818729 6 Human chr2:15629018-15651474 circRNA adriamycin (ADR) acute myeloid leukemia (AML) HL-60 cells adriamycin (ADR) treatment upregulated 31818729 7 Human chr4:52729603-52780244+ circRNA gemcitabine (GEM) pancreatic cancer (PC) PANC-1 cells gemcitabine (GEM) treatment chr4:52729603-52780244+ was found significantly upregulated in non-responsive group. 29922161 8 Human chr7:2330794-22357656 circRNA adriamycin (ADR) acute myeloid leukemia (AML) HL-60 cells adriamycin (ADR) treatment upregulated 31818729 9 Human chr7:2330794-22357656- circRNA adriamycin (ADR) acute myeloid leukemia (AML) HL-60 cells adriamycin (ADR) treatment upregulated 31818729 10 Human circABCB10 circRNA paclitaxel (PTX) breast cancer BC tissues; MCF-7 cells MDA-MB-231 Paclitaxel (PTX) treatment upregulated 32273769 11 Human circABCB10 circRNA cisplatin (DDP) lung cancer A549 cells; NCl H292 cells cisplatin treatment downregulated 31931771 12 Human circACTR2 circRNA glucose diabetic nephropathy (DN) HK-2 cells glucose treatment "CircACTR2 regulates high glucose-induced pyroptosis, inflammation and fibrosis in proximal tubular cells." 32115515 13 Human circADAM9 circRNA high glucose (HG) dysfunction of endothelial progenitor cells (EPCs) human endothelial progenitor cells (EPCs) high glucose (HG) treatment Circ-ADAM9 targeting PTEN and ATG7 promotes autophagy and apoptosis of diabetic endothelial progenitor cells by sponging mir-20a-5p. 32661238 14 Human circANKRD11 circRNA cigarette smoke extract (CSE) chronic obstructive pulmonary disease (COPD) Human pulmonary microvascular endothelial cells HPMECs cigarette smoke extract (CSE) treatment "CircANKRD11 and BRD4 expression were increased, whereas miR-145-5p expression was decreased in the lung tissues of smokers with or without COPD and CSE-induced HPMECs" 33833509 15 Human circANKRD36 circRNA lipopolysaccharide (LPS) bedsore HaCaT cells lipopolysaccharide (LPS) treatment upregulated 31692058 16 Human circANKRD36 circRNA lipopolysaccharide (LPS) inflammatory injury HaCaT cells lipopolysaccharide (LPS) treatment circANKRD36 remitted cell inflammatory damage upregulating miR-15/MyD88 via the NF-¦ÊB pathway in HaCaT cells. 31692058 17 Human circANKRD36 circRNA IL-1¦Â osteoarthritis (OA) human chondrocytes IL-1¦Â treatment circANKRD36 sponge miR-599 to up-regulate the expression of Casz1 and thus prevent apoptosis and inflammation in OA. 33205602 18 Human circANKRD36 circRNA lipopolysaccharide (LPS) pneumonia MRC-5 cells lipopolysaccharide (LPS) treatment LPS irritation raised the level of circANKRD36 in MRC-5 cells. 31793082 19 Human circANKRD36 circRNA sepsis pneumonia human embryonic lung fibroblast MRC-5 cell human embryonic lung fibroblast MRC-5 cell injury irritated by lipopolysaccharide (LPS) treatment "LPS aroused a decrease in viability, increases in apoptosis, ROS, and IL-6, IL-8, and TNF-¦Á, along with circANKRD36, and activation of NF-¦ÊB pathway Silencing circANKRD36 weakened the above-mentioned influences of LPS" 31793082 20 Human circANRIL circRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia/reperfusion (I/R) injury human brain microvascular endothelial cells (HBMECs) oxygen-glucose deprivation and reoxygenation (OGD/R) treatment "The expression of circ_ANRIL in OGD/R-induced human brain microvascular endothelial cells (HBMECs) was significantly upregulated, while that of miR-622 was significantly downregulated" 32616043 21 Human circANRIL circRNA lipopolysaccharide (LPS) inflammation HK-2 cells lipopolysaccharides (LPS) treatment upregulated 31432701 22 Human circARF3 circRNA tumor necrosis factor alpha (TNF-¦Á) encephalitis SH-SY5Y cells tumor necrosis factor alpha (TNF-¦Á) treatment TNF-¦Á inducement also markedly reduced circARF3 expression. 32329660 23 Human circARL3 circRNA hepatitis B virus (HBV) hepatocellular carcinoma (HCC) HCC tissues hepatitis B virus (HBV) infection upregulated 33372396 24 Human circATP2B4 circRNA hypoxia pulmonary arterial hypertension (PAH) pulmonary arterial smooth muscle cells (PASMCs) hypoxia treatment CircATP2B4 potentiated hypoxia-induced proliferation and migration of PASMCs through the miR-223/ATR axis. 32926932 25 Human circAtp9b circRNA lipopolysaccharide (LPS) inflammation MRC-5 cells lipopolysaccharide (LPS) treatment LPS triggered adverse inflammation response by elevating the biogenesis of circAtp9b which caused a repressive role in miR-27a expression. 31735661 26 Human circAtp9b circRNA lipopolysaccharide (LPS) pneumonia MRC-5 cells lipopolysaccharide (LPS) treatment LPS triggered adverse inflammation response by elevating the biogenesis of circAtp9b which caused a repressive role in miR-27a expression. 31735661 27 Human circBCRC4 circRNA gambogic acid (GA) bladder cancer T24T and UMUC3 cells Gallic acid (GA) treatment upregulated 29270748 28 Human circBPTF circRNA high glucose (HG) endothelial dysfunction human umbilical vein endothelial cells (HUVECs) high glucose (HG) treatment CircBPTF knockdown protected against HG-induced inflammatory injuries and oxidative stress by mediating the miR-384/LIN28B axis in HUVECs. 32524321 29 Human circCamk4 circRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia/reperfusion (I/R) injury SH-SY5Y Cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment circ-camk4 (hsa-circ-camk4) are elevated in SH-SY5Y cells exposed to OGD/R treatment 32332879 30 Human circCCDC66 circRNA oxaliplatin colorectal cancer (CRC) HCT116 cells; HT-29 cells oxaliplatin (OXA) treatment circCCDC66 is elevated in colorectal cancer cells with resistance to oxaliplatin 32187976 31 Human circCCDC66 circRNA oxaliplatin colorectal cancer (CRC) HCT116 cells; HT-29 cells oxaliplatin treatment circCCDC66 is elevated in colorectal cancer cells with resistance to oxaliplatin 32187976 32 Human circCDK8 circRNA CoCl2 periodontitis human Periodontal ligament stem cells (PDLSCs) CoCl2 treatment upregulated 32978798 33 Human circCDR1as circRNA cisplatin (DDP) bladder cancer "human bladder cancer cell lines TCCSUP, 5367, T24 and EJ" cisplatin treatment Cdr1as induced the apoptosis and enhanced the cisplatin chemosensitivity of bladder cancer cells both in vitro and in vivo. 31131537 34 Human circCDR1as circRNA 3-methyladenine (3-MA) oral squamous cell carcinoma (OSCC) Tca-8113 cells 3-Methyladenine (3-MA) treatment upregulated 31582727 35 Human circCDR1as circRNA hypoxia oral squamous cell carcinoma (OSCC) Tca-8113 cells hypoxia induce upregulated 31582727 36 Human circCDR1as circRNA rapamycin oral squamous cell carcinoma (OSCC) Tca-8113 cells rapamycin treatment upregulated 31582727 37 Human circCDR1as circRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment upregulated 32018039 38 Human circCDR1as circRNA cisplatin (DDP) ovarian cancer (OC) Human ovarian cancer cell lines (A2780 and SKOV-3) cisplatin treatment there was a decreasing trend in Cdr1as levels from normal ovarian tissues to cisplatinsensitive ovarian cancer tissues and then to cisplatin-resistant ovarian cancer tissues. Cdr1as Enhances the Cisplatin Chemosensitivity of Ovarian Cancer In Vitro. 31479922 39 Human circCDR1as circRNA lipopolysaccharide (LPS) periodontitis Human periodontal ligament cells (PDLCs) lipopolysaccharide (LPS) treatment "CDR1as was significantly downregulated in LPS-treated PDLSCs compared to untreated cells, as well as in normal periodontal ligament tissues compared to periodontitis tissues." 31582895 40 Human circCDR1as circRNA hypoxia pulmonary hypertension (PH) Human pulmonary artery smooth muscle cell (HPASMC) hypoxia treatment CDR1as/miR-7-5p/CNN3 and CAMK2D regulatory axis mediates HPASMC osteoblastic differentiation and calcification induced by hypoxia. 33230455 41 Human circCDR1as circRNA silica silicosis HBE cells; A549 cells silica treatment The increase of circRNA CDR1as was observed after treatment of silica 30202956 42 Human circCHFR circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human vascular smooth muscle cells (VSMCs) oxidized low-density lipoprotein (ox-LDL) treatment Circ_CHFR contributed to the progression of AS through the miR-214-3p/Wnt3/¦Â-catenin signals. 32271446 43 Human circChr19 circRNA ebola virus (EBOV) Ebola virus (EBOV) therapy 293T cells EBOV treatment upregulated 29209594 44 Human circCIDN circRNA compression force (CF) intervertebral disc degeneration (IDD) nucleus pulposus (NP) cells compression treatment CircRNA-CIDN was significantly downregulated in compression-treated human NP cells. 32114390 45 Human circCILinc02 circRNA methylene blue (MB) osteoarthritis (OA) chondrocytes methylene blue treatment CILinc02 was increased in primary cells of OA but was reduced in primary OA cells treated with MB. 30548658 46 Human circCircNFIX circRNA temozolomide (TMZ) glioblastoma multiforme (GBM) LN229 cells; U251 cells temozolomide (TMZ) treatment Exosome-mediated transfer of circRNA CircNFIX enhances temozolomide resistance in glioma 32194140 47 Human circCLASP2 circRNA high glucose (HG) diabetic-associated vascular injury Human umbilical vein endothelial cells (HUVECs) high-glucose (HG) treatment High glucose (HG) exposure downregulated the expression of circ_CLASP2 in HUVECs 33776760 48 Human circCOG8 circRNA mechanical stress intervertebral disc degeneration (IDD) NP cells mechanical stress treatment circCOG8 expression was obviously downregulated by the mechanical stress in disk NP cells. 33195225 49 Human circCOL1A2 circRNA high glucose (HG) diabetic retinopathy (DR) human retinal microvascular endothelial cells (hRMECs) high glucose (HG) treatment Circular RNA COL1A2 promotes angiogenesis via regulating miR-29b/VEGF axis in diabetic retinopathy. 32497630 50 Human circDHRS3 circRNA IL-1¦Â osteoarthritis (OA) human chondrocytes IL-1¦Â treatment Circ_DHRS3 expression was elevated in OA cartilage tissues and IL-1¦Â-treated chondrocytes. 33360372 51 Human circDHRS3 circRNA IL-1¦Â osteoarthritis (OA) chondrocytes IL-1¦Â treatment Circ_DHRS3 expression was elevated in OA cartilage tissues and IL-1¦Â-treated chondrocytes. 33360372 52 Human circDLGAP4 circRNA hypoxia ischemia/reperfusion (I/R) injury Human umbilical vein endothelial cells (HUVECs) hypoxia induce downregulated 31607223 53 Human circDLGAP4 circRNA "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)" parkinson's disease (PD) Human neuroblastoma cell line SH-SY5Y "1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) treatment" circDLGAP4 expression was decreased in MPTP-induced PD mouse model and MPP+-induced PD cell models. 31761328 54 Human circDLGAP4 circRNA 1-methyl-4-phenylpyridinium (MPP+) parkinson's disease (PD) SH-SY5Y Cells 1-methyl-4-phenylpyridinium (MPP+) treatment circDLGAP4 expression was decreased in MPP+-induced PD cell models. 31761328 55 Human circDNMT3B circRNA high glucose (HG) diabetic retinopathy (DR) human retinal microvascular endothelial cells (HRMECs) High Glucose (HG) treatment downregulated 31636010 56 Human circDONSON circRNA cisplatin (DDP) gastric cancer (GC) AGS cells; HGC cells cisplatin treatment circDONSON promoted cisplatin resistance in gastric cancer cells by regulating miR-802/BMI1 axis. 32581651 57 Human circDROSHA circRNA magnesium-free extracellular fluid temporal lobe epilepsy (TLE) SK-N-SH cells; IMR-32 cells magnesium-free extracellular solution downregulated 33370579 58 Human circDYM circRNA repetitive transcranial magnetic stimulation (rTMS) breast cancer plasma repetitive transcranial magnetic stimulation (rTMS) treatment circDYM expression was upregulated after rTMS treatment 32663980 59 Human circERCC2 circRNA tert-butyl hydroperoxide (TBHP) intervertebral disc degeneration (IDD) nucleus pulposus cells (NPCs) tert-butyl hydroperoxide (TBHP) treatment downregulated 31582722 60 Human circFAM172A circRNA 5-fluorouracil (5-Fu) osteosarcoma (OS) MG63 cells 5-fluorouracil (5-FU) treatment upregulated 33308021 61 Human circFANCA circRNA lipopolysaccharide (LPS) acute kidney injury (AKI) Human renal proximal tubular cell line HK-2 lipopolysaccharide (LPS) treatment Circ-FANCA was upregulated in septic AKI serum specimens and LPS-treated HK2 cells. 33468219 62 Human circFBXW7 circRNA oxaliplatin colorectal cancer (CRC) SW480 cells; HCT116 cells; colorectal cancer (CRC) tissues oxaliplatin treatment circ-FBXW7 was measured and results showed circ-FBXW7 was lower in oxaliplatin-resistant CRC patients and resistant CRC cells than that in controls 33147048 63 Human circFLNA circRNA fucoidan oral squamous cell carcinoma (OSCC) SCC15 cells; SCC25 cells fucoidan treatment upregulated 31495936 64 Human circFLNA circRNA fucoidan oral squamous cell carcinoma (OSCC) Human tongue squamous carcinoma cells (SCC15 and SCC25) fucoidan treatment upregulated 31495936 65 Human circFN1 circRNA cisplatin (DDP) gastric cancer (GC) SGC7901 cells; BGC823C cells cisplatin treatment circFN1 enhances cisplatin resistance in gastric cancer via sponging miR-182-5p. 31898357 66 Human circFOXM1 circRNA naringenin lung cancer A549 cells; PC9 cells naringenin treatment Naringenin hindered cell metastasis in vitro and tumor growth in vivo by reducing circFOXM1 and SPAG5 expression and inducing the expression of miR-3619-5p in lung cancer. 32598178 67 Human circGCN1L1 circRNA tumor necrosis factor alpha (TNF-¦Á) temporomandibular joint osteoarthritis synoviocyte tumor necrosis factor alpha (TNF-¦Á) treatment upregulated 32332704 68 Human circGRN circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human vascular smooth muscle cells (HVSMCs) oxidized low-density lipoprotein (ox-LDL) treatment "In this study, we found that circ_GRN was elevated in the serum of AS and oxidized low-density lipoprotein (ox-LDL)-induced HVSMCs." 33818550 69 Human circHDAC9 circRNA amyloid-¦Â (A¦Â) 42 Alzheimer's disease (AD) HN cells amyloid-¦Â (A¦Â) 42 treatment Berberine attenuates A¦Â42-induced neuronal damage through regulating circHDAC9/miR-142-5p axis in human neuronal cells 32251633 70 Human circHECTD1 circRNA silicon dioxide (SiO2) macrophage activation Primary cultures of alveolar macrophages from healthy donors and patients silicon dioxide (SiO2) treatment downregulated 29290828 71 Human circHECTD1 circRNA SiO2 silicosis HPF-a cells SiO2 treatment "After exposure to SiO2, the circHECTD1 level was decreased, which was associated with an increase in HECTD1 in HPF-a cells SiO2-induced autophagy was reversed by either circHECTD1 overexpression or HECTD1 knockdown in HPF-a cells" 31832126 72 Human circHIAT1 circRNA baicalin (BAI) cervical cancer (CC) Human CC cell lines (HeLa and SiHa) baicalin (BAI) treatment upregulated 33603395 73 Human circHIPK3 circRNA platelet-derived growth factor (PDGF) airway remodeling airway smooth muscle cells (ASMCs) platelet-derived growth factor (PDGF) treatment circHIPK3 was significantly upregulated in platelet-derived growth factor (PDGF) induced ASMCs 32450169 74 Human circHIPK3 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human umbilical vein endothelial cells (HUVECs) oxidized low-density lipoprotein (ox-LDL) treatment The expression of circHIPK3 was downregulated in ox-LDL treated HUVECs. 33378035 75 Human circHIPK3 circRNA H2O2 cytotoxicity OB-6 cells Hydrogen peroxide (H2O2) treatment downregulated 31955154 76 Human circHIPK3 circRNA oleic acid (OA) diabetes-associated metabolic disorders HepG2 cells oleate treatment circHIPK3 contributes to hyperglycemia and insulin resistance by sponging miR-192-5p and up-regulating FOXO1. 31875589 77 Human circHIPK3 circRNA high glucose (HG) diabetic nephropathy (DN) HK-2 cells high glucose (HG) treatment Expression level of circHIPK3 in HK-2 cells was remarkably decreased after the treatment of HG. 33628038 78 Human circHIPK3 circRNA temozolomide (TMZ) glioblastoma multiforme (GBM) A172 cells; U251 cells temozolomide (TMZ) treatment "Circ-HIPK3 was obviously increased in TMZ-resistant glioma cells and their exosomes, miR-421, was downregulated in TMZ-resistant glioma" 32644821 79 Human circHIPK3 circRNA oleic acid (OA) hyperglycemia and insulin resistance HepG2 cells oleate treatment upregulated 31875589 80 Human circHIPK3 circRNA oxygen-glucose deprivation and reoxygenation (OGD/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) Human-derived cardiomyocytes HCM oxygen-glucose deprivation and reoxygenation (OGD/R) treatment CircHIPK3 was highly expressed in HCM cells with simulated myocardial I/R relative to those with normoxic treatment 31799682 81 Human circHIPK3 circRNA dexamethasone (DEX) osteoblast injury OB-6 osteoblastic cells and primary human osteoblasts dexamethasone (DEX) treatment circHIPK3 expression was downregulated in DEX-treated human osteoblasts and circHIPK3 levels decreased in human necrotic femoral head tissues. In OB-6 osteoblastic cells and primary human osteoblasts ectopic overexpression of circHIPK3 potently suppressed DEX-induced apoptosis and programmed necrosis. 31242973 82 Human circHIPK3 circRNA gemcitabine (GEM) pancreatic cancer (PC) Pancreatic cancer tissues; PANC-1 cells; SW-1990 cells Gemcitabine (GEM) treatment circHIPK3 was also increased in GEM-resistant PC tumors tissues and GEM-resistant PC cells. 32104074 83 Human circHIPK3 circRNA CoCl2 spinal cord injury (SCI) AGE1.HN CoCl2 treatment circ-HIPK3 relieves the neuronal cell apoptosis through regulating miR-588/DPYSL5 axis in SCI. 32247616 84 Human circHIPK3 circRNA CoCl2 spinal cord injury (SCI) AGE1.HN cells ?CoCl2 treatment Circ_HIPK3 expression was inhibited by CoCl2?in AGE1.HN cells. 33770577 85 Human circHIPK3 circRNA high glucose (HG) vascular injury human umbilical vein endothelial cells (HUVECs) high glucose (HG) treatment downregulated 30454897 86 Human circHMGCS1 circRNA sevoflurane (SEV) colorectal cancer (CRC) SW480 cells; LOVO cells sevoflurane treatment sevoflurane inhibited colon cancer progression by modulating the exosome-transmitted circ-HMGCS1/miR-34a-5p/SGPP1 axis 33125091 87 Human circINO80 circRNA Nel-like molecule type 1 (NELL-1) osteogenesis human adipose-derived stem cells (hASCs) "recombinant nel-like molecule, type 1 (NELL-1) treatment" upregulated 31633307 88 Human circIQGAP1 circRNA IL-1¦Â osteoarthritis (OA) CHON-001 cells IL-1¦Â treatment "Circ-IQGAP1 abundance was enhanced in the cartilage tissues from OA patients compared with normal subjects (n = 32), and its expression was increased in CHON-001 cells after treatment of IL-1¦Â in a dose-dependent pattern." 33675175 89 Human circITCH circRNA doxorubicin (DOX) doxorubicin (DOX)-induced cardiotoxicity human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) doxorubicin treatment "The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a" 32392088 90 Human circITCH circRNA lidocaine hepatocellular carcinoma (HCC) HCC cells ?lidocaine treatment "circ_ITCH and CPEB3 levels were decreased in hepatocellular carcinoma tissues and cells, and were restored in cells via lidocaine treatment" 33433806 91 Human circLARP4 circRNA cisplatin (DDP) osteosarcoma (OS) MG63 cells cisplatin treatment "Circ-LARP4 high expression correlates with decreased Enneking stage and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging miR-424 in osteosarcoma." 31642110 92 Human circLARP4 circRNA cisplatin and doxorubicin osteosarcoma (OS) MG63 cells cisplatin and doxorubicin treatment "Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma." 31642110 93 Human circLARP4 circRNA doxorubicin (DOX) osteosarcoma (OS) MG63 cells doxorubicin treatment "Circ-LARP4 high expression correlates with decreased Enneking stage and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging miR-424 in osteosarcoma." 31642110 94 Human circLRP6 circRNA arsenite arsenite-induced carcinogenesis human keratinocyte (HaCaT) cells arsenite exposure upregulated 29216394 95 Human circMCTP2 circRNA cisplatin (DDP) gastric cancer (GC) BGC823 cisplatin (DPP) treatment CircMCTP2 sensitizes GC to CDDP through the upregulation of MTMR3 by sponging miR-99a-5p. 33198772 96 Human circMTHFD2 circRNA pemetrexed gastric cancer (GC) Human gastric cancer MGC-803 cells pemetrexed (MTA) treatment "Compared with MGC-803/MTA resistant cells, the drug resistance of cells increased significantly in circ MTHFD2 overexpression group" 31841184 97 Human circMTO1 circRNA TGF-¦Â1 liver fibrosis LX©\2 cells transforming growth factor-¦Â1 (TGF-¦Â1) treatment downregulated 31148365 98 Human circNFXL1_009 circRNA hypoxia pulmonary arterial hypertension (PAH) human pulmonary arterial smooth muscle cells (hPASMCs) hypoxia treatment exposure to hypoxia markedly reduced the hsa_circNFXL1_009 level in cultured hPASMCs. 33614247 99 Human circNRIP1 circRNA hypoxia gastric cancer (GC) SGC-7901; AGS; MKN-45; BGC-823 hypoxia treatment upregulated 32425596 100 Human circNSUN2 circRNA aloperine colorectal cancer (CRC) SW480 and HT29 cells aloperine treatment downregulated 33664565 101 Human circOSBPL2 circRNA cigarette smoke extract (CSE) chronic obstructive pulmonary disease (COPD) human bronchial epithelial cells (HBECs) cigarette smoke extract (CSE) treatment "Circ-OSBPL2 was highly expressed in lung tissues of smokers without or with COPD, particularly in smokers with COPD." 33854310 102 Human circPAN3 circRNA doxorubicin (DOX) acute myeloid leukemia (AML) human AML cells THP-1 and K562 doxorubicin treatment "circPAN3 is most likely a key mediator in the development of AML drug resistance, evidenced by the increased expression in ADM-resistant cell lines and BM samples from relapsed patients." 31401408 103 Human circPHC3 circRNA oxygen glucose deprivation (OGD) ischemic stroke (IS) human brain microvascular endothelial cells (BMECs) oxygen glucose deprivation (OGD) treatment CircPHC3 was highly expressed in human BMECs after OGD 33519202 104 Human circPostn circRNA hypoxia/reoxygenation (H/R) myocardial infarction (MI) human cardiomyocytes hypoxia and reoxygenation (H/R) treatment "We identified that the expression of circPostn was elevated in the plasma of MI patients, MI mouse model, and hypoxia and reoxygenation (H/R)-treated human cardiomyocytes." 33681183 105 Human circPRKCA circRNA curcumin (Cur) non-small cell lung cancer (NSCLC) "NSCLC cells (H1650, H1299, H460, A549)" curcumin treatment "After curcumin treatment, the expression tendency of circ-PRKCA, miR-384, and ITGB1 in NSCLC cells was overturned." 33684690 106 Human circPRKCB circRNA hypoxia/reoxygenation (H/R) intestinal ischemia/reperfusion (I/R) injury Caco-2 cells hypoxia/reoxygenation (H/R) treatment circ-PRKCB/miR-339-5p/p66Shc signaling pathway in regulating oxidative stress in the I/R intestine. 32929374 107 Human circPRKCI circRNA lipopolysaccharide (LPS) HK-2 cells injury HK-2 cells Lipopolysaccharide (LPS) treatment highly expressed circPRKCI relieved inflammatory injury induced by LPS in HK2 cells by suppressing miR-545/ZEBs and depressing the briskness of NF-kB pathway. 32104945 108 Human circPRKCI circRNA H2O2 oxidative stress SH-SY5Y neuronal cells H2O2 treatment downregulated 31053300 109 Human circPRMT5 circRNA cisplatin (DDP) non-small cell lung cancer (NSCLC) A549 cells; H460 cells cisplatin treatment Circ-PRMT5 promoted DDP resistance via REV3L by sponging miR-4458 in NSCLC 32808744 110 Human circPTPRA circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) Human vascular smooth muscle cell line (VSMCs) oxidized low-density lipoprotein (ox-LDL) treatment upregulated 33336764 111 Human circPUM1 circRNA insulin polycystic ovarian syndrome (PCOS) KGN cells; SVOG cells insulin treatment upregulated 32540374 112 Human circPVT1 circRNA paclitaxel (PTX) gastric cancer (GC) "Human GC tissues and tumor cell lines (MKN-45, HGC-27, MGC-803, and AGS)" paclitaxel (PTX) treatment circ-PVT1 expression was upregulated in PTX-resistant GC tissues and cells. Circ-PVT1 downregulated enhanced PTX sensitivity in PTX-resistant GC cells by negatively regulating miR-124-3p. 31793989 113 Human circPVT1 circRNA propofol (PPF) gastric cancer (GC) HGC-27 cells; AGS cells Propofol treatment "Propofol inhibited the proliferation and invasion, but enhanced the apoptosis of GC cells by regulating the circ-PVT1/miR-195-5p/ETS1 axis" 32945521 114 Human circPVT1 circRNA cisplatin and pemetrexed lung adenocarcinoma (LUAD) A549/DR cells cisplatin and pemetrexed treatment circPVT1 contributes to cisplatin and pemetrexed chemotherapy resistance through miR-145-5p/ABCC1 axis. 31986409 115 Human circPWWP2A circRNA mycobacterium tuberculosis (Mtb) apoptosis primary human monocyte-derived macrophages Mycobacterium tuberculosis (MTB) infection downregulated 31434611 116 Human circPWWP2A circRNA dexamethasone (DEX) cytotoxicity DEX-treated human OB-6 osteoblastic cells dexamethasone (Dex) treatment cPWWP2A is downregulated in the necrotic femoral head tissues of DEX-taking human patients as well as in DEX-treated human osteoblasts. cPWWP2A silencing or forced miR-579 overexpression induced significant cytotoxicity in human osteoblasts. 31376935 117 Human circPWWP2A circRNA lipopolysaccharide (LPS) liver fibrosis human HSC line LX2 cells lipopolysaccharide (LPS) treatment upregulated 31719209 118 Human circPWWP2A circRNA TGF-¦Â liver fibrosis Human HSC line LX2 cells TGF-¦Â treatment upregulated 31719209 119 Human circRACGAP1 circRNA apatinib advanced gastric cancers (AGCs) BGC-823 and HGC-27 apatinib treatment Silencing of circRACGAP1 sensitizes gastric cancer cells to apatinib via modulating autophagy by targeting miR-3657 and ATG7 32139670 120 Human circRELL1 circRNA oxidized low density lipoprotein (ox-LDL) endothelial inflammation human umbilical vein endothelial cells (HUVECs) oxidized low-density lipoprotein (ox-LDL) treatment circ-RELL1 modulate inflammatory response by miR-6873-3p/MyD88/NF-¦ÊB axis in ox-LDL induced endothelial cells. 33008595 121 Human circRFWD2 circRNA Nel-like molecule type 1 (NELL-1) osteogenesis human adipose-derived stem cells (hASCs) recombinant nel-like molecule type 1 (NELL-1) treatment upregulated 31633307 122 Human circRHOT1 circRNA propofol (PPF) non-small cell lung cancer (NSCLC) human bronchial epithelioid(16HBE) Propofol treatment "?Importantly, treatment with Propofol inhibited circ-RHOT1 expression in NSCLC cells" 33515563 123 Human circRIMS2 circRNA aerobic exercise vascular cognitive impairment (VCI) serum aerobic exercise training (AET) treatment "Aerobic exercise could shorten the average time that mice reached the platform in the Morris water maze, increase the expression level of circRIMS2 and BDNF, reduce miR-186 expression, and inhibit neuronal apoptosis." 33413076 124 Human circRSF circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human aortic endothelial cells (HAECs) oxidized low-density lipoprotein (ox-LDL) treatment CircRSF1 could protect against ox-LDL-induced endothelial cell injury in vitro via miR-758/CCND2 axis 32791147 125 Human circRSF1 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human umbilical vein endothelial cells (HUVECs) oxidized low-density lipoprotein (ox-LDL) treatment "In this study, ox-LDL inhibited circRSF1 and HDAC1 expression while upregulated miR-135b-5p expression in Human umbilical vein endothelial cells (HUVECs)." 33757583 126 Human circRSF1 circRNA radiation radiation-induced liver disease (RILD) LX2 cells radiation treatment CircRNA RSF1 (circRSF1) was upregulated in irradiated LX2 cells 31960423 127 Human circS-7 circRNA IL-1¦Â osteoarthritis (OA) Human OA chondrocytes (C28/12 cell line) IL-1¦Â treatment downregulated 30925324 128 Human circS-7 circRNA ultraviolet (UV) irradiation pigmented skin diseases HaCaT cells; FB cells Ultraviolet B (UVB)? treatment upregulated 33687273 129 Human circSEC24A circRNA IL-1¦Â osteoarthritis (OA) human chondrocytes IL-1¦Â treatment "CircSEC24A and SOX5 expression were enhanced, while miR-142-5p level was reduced in OA cartilage tissues and chondrocytes." 33751650 130 Human circSEMA4B circRNA IL-1¦Â intervertebral disc degeneration (IDD) NPC IL-1¦Â treatment IL-1¦Â stimulation also dramatically inhibited circSEMA4B expression. 30251693 131 Human circSERPINE2 circRNA IL-1¦Â osteoarthritis (OA) CHON-001 cells IL-1¦Â treatment CircSERPINE2 could mediate TGFBR2 expression by binding with miR-495. 33094798 132 Human circSFMBT2 circRNA platelet derived growth factor-BB (PDGF-BB) proliferative vascular diseases Human VSMCs platelet derived growth factor-BB (PDGF-BB) treatment circSFMBT2 plays a vital role in VSMC proliferation and migration through the miR-331/HDAC5/Aggf1 axis 33166591 133 Human circSFMBT2 circRNA platelet derived growth factor-BB (PDGF-BB) proliferative vascular diseases vascular smooth muscle cell (VSMC) platelet derived growth factor-BB (PDGF-BB) treatment upregulated 33166591 134 Human circSLC7A6 circRNA matrine colorectal cancer (CRC) cancer-associated fibroblasts matrine treatment circRNAs (circSLC7A6) was significantly downregulated in CM of CAFs with matrine treatment. 32423804 135 Human circSMARCA5 circRNA cisplatin and gemcitabine non-small cell lung cancer (NSCLC) NCI©\H1299 cells; NCI©\H1437 cells cisplatin and gemcitabine treatment Circular RNA SMARCA5 may serve as a tumor suppressor in non-small cell lung cancer. 31944395 136 Human circSMARCA5 circRNA double hydrogen testosterone (DHT) prostate cancer LNCaP cells double hydrogen testosterone (DHT) treatment upregulated 28765045 137 Human circSORE circRNA sorafenib (SOR) hepatocellular carcinoma (HCC) HepG2 cells; SKhep1 cells; Huh7 cells; LM3 cells sorafenib treatment upregulated 33222692 138 Human circTADA2A circRNA platelet derived growth factor-BB (PDGF-BB) and insulin-like growth factor (IGF)-1 idiopathic pulmonary fibrosis (IPF) human fibroblastic cell line (LL-24) PDGF-BB and IGF-1 treatment circTADA2A repressed lung-fibroblasts activation via miR-526b/Cav1 and reduced lung-fibroblasts proliferation via miR-203/Cav2 32694556 139 Human circTIMP2 circRNA TNF-¦Á and IL-1¦Â intervertebral disc degeneration (IDD) NP cells TNF-¦Á and IL-1¦Â treatment circ-TIMP2 promoted TNF-¦Á- and IL-1¦Â-induced NP cell imbalance between ECM anabolism and catabolism via miR-185-5p-MMP2 signaling 32626912 140 Human circTM7SF3 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) THP-1-derived macrophages and differentiated human monocyte-derived macrophages (hMDMs) oxidized low-density lipoprotein (ox-LDL) treatment CircTM7SF3 level was markedly increased in the serum samples of AS patients and ox-LDL-induced THP-1-derived macrophages compared with their matching counterparts. 33526034 141 Human circTMBIM6 circRNA IL-1¦Â and TNF-¦Á osteoarthritis (OA) Chondrocytes IL-1¦Â and TNF-¦Á treatment CircTMBIM6 promotes osteoarthritis-induced chondrocyte extracellular matrix degradation via miR-27a/MMP13 axis. 32767318 142 Human circTtc3 circRNA hypoxia pressure ulcer (PU) HaCaT cells hypoxia treatment circ-Ttc3 alleviated hypoxic injury and activated NF-¦ÊB and PI3K/AKT pathways by downregulating miR-449a in HaCaT cells. 32043754 143 Human circTUBD1 circRNA irradiation and lipopolysaccharide (LPS) radiation-induced liver disease (RILD) LX-2 cells irradiation and lipopolysaccharide (LPS) treatment Circular RNA TUBD1 Acts as the miR-146a-5p Sponge to Affect the Viability and Pro-Inflammatory Cytokine Production of LX-2 Cells through the TLR4 Pathway. 32097101 144 Human circUBE2G1 circRNA lipopolysaccharide (LPS) osteoarthritis (OA) C28/I2 cells lipopolysaccharide (LPS) treatment circRNA-UBE2G1 facilitates the progression in the LPS-induced OA cell model via regulating the miR-373/HIF-1a axis. 32476580 145 Human circUSP36 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human umbilical vein smooth muscle cells (HUVSMCs) oxidized low-density lipoprotein (ox-LDL) treatment Knockdown of circ_USP36 alleviated ox-LDL-mediated injury of HUVSMCs by modulating miR-182-5p/KLF5 axis 33437365 146 Human circUSP36 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human umbilical vein endothelial cells (HUVECs) oxidized low-density lipoprotein (ox-LDL) treatment Ox-LDL exposure induced the upregulation of circ-USP36 in HUVEC cells. 33249762 147 Human circUSP36 circRNA oxidized low density lipoprotein (ox-LDL) endothelial cell injury human umbilical vein endothelial cells (HUVECs) oxidized low-density lipoprotein (ox-LDL) treatment Ox-LDL exposure induced the upregulation of circ-USP36 in HUVEC cells. 33249762 148 Human circUSP45 circRNA glucocorticoid (GC) glucocorticoid-induced osteonecrosis of femoral head (GIONFH) femoral heads glucocorticoids (GCs) treatment upregulated 30579595 149 Human circUSP45 circRNA glucocorticoid (GC) glucocorticoid-induced osteonecrosis of femoral head (GIONFH) human Bone mesenchymal stem cells (BMSCs) glucocorticoids (GCs) treatment upregulated 30579595 150 Human circVEGFC circRNA high glucose (HG) diabetes mellitus (DM) human umbilical vein endothelial cells (HUVECs) high glucose (HG) treatment upregulated 32680978 151 Human circVIRF4 circRNA Kaposi¡¯s sarcoma-associated herpesvirus (KSHV) kaposi¡¯s sarcoma-associated herpesvirus (KSHV) infection primary effusion lymphoma (PEL) cell lines Kaposi¡¯s sarcoma-associated herpesvirus (KSHV) infection upregulated 31911496 152 Human circVMA21 circRNA lipopolysaccharide (LPS) sepsis THP-1 cells lipopolysaccharide (LPS) treatment "CircVMA21 and NRP1 were decreased, and miR-199a-5p was increased in LPS-induced THP-1 cells." 33647793 153 Human circVPS13C circRNA propofol (PPF) ovarian cancer (OC) ovarian cancer cell lines (A2780 and SKOV3) Propofol treatment Propofol suppressed the progression of ovarian cancer through up-regulating miR-145 via suppressing circVPS13C 33563314 154 Human circVPS18 circRNA temozolomide (TMZ) glioblastoma multiforme (GBM) U251 cells; LN229 cells; glioma tissues temozolomide (TMZ) treatment Circ-VPS18 expression was upregulated in TMZ-resistant glioma tissues and glioma cells 33188501 155 Human circWBSCR17 circRNA high glucose (HG) diabetic nephropathy (DN) HK-2 cells high glucose (HG) treatment Circ_WBSCR17 aggravates inflammatory responses and fibrosis by targeting miR-185-5p/SOX6 regulatory axis in high glucose-induced human kidney tubular cells 32798559 156 Human circWDR77 circRNA high glucose (HG) diabetes mellitus (DM) human vascular smooth muscle cells (VSMCs) upregulated 29042195 157 Human circZC3H4 circRNA SiO2 epithelial-mesenchymal transition (EMT) MLE-12 cells SiO2 treatment upregulated 30826420 158 Human circZC3H4 circRNA silicon dioxide (SiO2) lung fibrosis lung tissues silicon dioxide (SiO2) treatment upregulated 29401612 159 Human circZNF292 circRNA hypoxia hepatocellular carcinoma (HCC) hepatoma SMMC7721 cells hypoxia induce upregulated 31028816 160 Human circZNF609 circRNA bovine serum albumin (BSA) focal segmental glomerulosclerosis (FSGS) HK-2 cells bovine serum albumin (BSA) treatment upregulated 32800553 161 Human circZNF609 circRNA H2O2 oxidative stress HaCaT cells H2O2 treatment Anti-antioxidant impacts of circZNF609 silence in HaCaT cells through regulating miR-145 33821719 162 Human circZNF652 circRNA lipopolysaccharide (LPS) infantile pneumonia (IP) WI-38 cells lipopolysaccharide (LPS) treatment LPS inducement remarkably enhanced the expression of circZNF652. 31889339 163 Human circZNF652 circRNA lipopolysaccharide (LPS) infantile pneumonia (IP) WI-38 cells lipopolysaccharide (LPS) treatment upregulated 31889339 164 Human hsa_circ_0000109 circRNA high glucose (HG) diabetes-associated endothelial dysfunction human umbilical vein endothelial cells (HUVECs) ?high glucose (HG) induce treatment dysregulated 31369204 165 Human hsa_circ_0000199 circRNA cisplatin (DDP) gastric cancer (GC) "GC tissues and cells SGC7901, BGC823" cisplatin treatment upregulated 30927924 166 Human hsa_circ_0000260 circRNA cisplatin (DDP) gastric adenocarcinoma (GAC) HGC27; AGS cisplatin treatment Circ_0000260 Regulates the Development and Deterioration of Gastric Adenocarcinoma with Cisplatin Resistance by Upregulating MMP11 via Targeting MiR-129-5p. 33122949 167 Human hsa_circ_0000285 circRNA cisplatin (DDP) bladder cancer bladder cancer tissues cisplatin treatment hsa_circ_0000285 expression was lower in cisplatin-resistant bladder cancer patients than in those who were cisplatin-sensitive. 30509102 168 Human hsa_circ_0000285 circRNA cisplatin (DDP) bladder cancer serum cisplatin treatment hsa_circ_0000285 expression was lower in cisplatin-resistant bladder cancer patients than in those who were cisplatin-sensitive. 30509102 169 Human hsa_circ_0000376 circRNA hypoxia non-small cell lung cancer (NSCLC) H522; H1975; BEAS-2B hypoxia treatment Circ_0000376 promoted NSCLC progression by regulating the miR-1182/NOVA2 axis 32922073 170 Human hsa_circ_000042 circRNA curcumin (Cur) nasopharyngeal carcinoma (NPC) CNE-2R cells curcumin treatment downregulated 31793078 171 Human hsa_circ_0000504 circRNA 5-fluorouracil (5-Fu) colorectal cancer (CRC) "human CRC cell line, HCT116" 5-fluorouracil (5-FU) treatment upregulated 28656150 172 Human hsa_circ_0000524 circRNA angiotensin II (Ang II) membranous nephropathy (MN) podocytes angiotensin II (Ang II) treatment "AngII treatment induced the overexpression of circ_0000524 and CXCL16, a decrease of miR-500a-5p, and induced cell apoptosis in podocytes." 32974919 173 Human hsa_circ_0000524 circRNA angiotensin II (Ang II) membranous nephropathy (MN) AB8/13 podocytes angiotensin II (Ang II) treatment "AngII treatment induced the overexpression of circ_0000524 and CXCL16, a decrease of miR-500a-5p." 32974919 174 Human hsa_circ_0000567 circRNA gefitinib non-small cell lung cancer (NSCLC) HCC827 cells; PC9 cells gefitinib treatment upregulated 32328186 175 Human hsa_circ_0000592 circRNA N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) gastric cancer (GC) malignant-transformed gastric epithelial cells (GES-1-T); normal gastric epithelial cells (GES-1-N) N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) treatment upregulated 31189743 176 Human hsa_circ_0000638 circRNA neodymium oxide (Nd2O3) inflammation human bronchial epithelial (16HBE) cells neodymium oxide treatment circRNA_0000638 was downregulated in neodymium oxide-treated 16HBE cells. 32199215 177 Human hsa_circ_0000657 circRNA microcystin-leucine arginine (MC-LR) hepatotoxicity human normal liver cell line (HL7702) MC-LR exposure downregulated 31825292 178 Human hsa_circ_0000659 circRNA microcystin-leucine arginine (MC-LR) hepatotoxicity human normal liver cell line (HL7702) MC-LR exposure downregulated 31825292 179 Human hsa_circ_0000735 circRNA docetaxel (DTX) prostate cancer PC-3 cells; DU145 cells docetaxel (DTX) treatment Hsa_circ_0000735 was upregulated in DTX-resistant PCa tissues and cells. 32714093 180 Human hsa_circ_0000977 circRNA hypoxia pancreatic cancer (PC) NK cells hypoxia induce upregulated 31402756 181 Human hsa_circ_0001013 circRNA 5-fluorouracil (5-Fu) osteosarcoma (OS) MG63 cells 5-fluorouracil (5-FU) treatment upregulated 33308021 182 Human hsa_circ_0001085 circRNA IFN-¦Ã epithelial-mesenchymal transition (EMT) PC-3M IE8 cells interferon-¦Ã (IFN-¦Ã) treatment downregulated in PC-3M IE8 cells in the EMT induction model 31882179 183 Human hsa_circ_0001085 circRNA IFN-¦Ã epithelial-mesenchymal transition (EMT) PC-3M IE8 cells IFN-¦Ã treatment downregulated 31882179 184 Human hsa_circ_0001165 circRNA IFN-¦Ã epithelial-mesenchymal transition (EMT) PC-3M IE8 cells interferon-¦Ã (IFN-¦Ã) treatment upregulated in PC-3M IE8 cells in the EMT induction model 31882179 185 Human hsa_circ_0001165 circRNA IFN-¦Ã epithelial-mesenchymal transition (EMT) PC-3M IE8 cells IFN-¦Ã treatment Hsa_circ_0001165 was upregulated in PC-3M IE8 cells treatment with IFN-¦Ã. 31882179 186 Human hsa_circ_0001173 circRNA high glucose (HG) gestational diabetes mellitus (GDM) HTR-8 cellsS;Vneo cells high-glucose (HG) treatment "In GDM patients, the expression of circ_0008285 was significantly upregulated, while that of circ_0001173 was decreased." 33879262 187 Human hsa_circ_0001204 circRNA mycobacterium tuberculosis (Mtb) tuberculosis (TB) human monocyte derived macrophages (MDMs) infect with Mtb dysregulated 29057952 188 Human hsa_circ_0001313 circRNA radiation colorectal cancer (CRC) colon cancer tissues radiation treatment circ_0001313 was significantly upregulated and miR-338-3p was downregulated in radio-resistant colon cancer tissues compared to radio-sensitive tissues 30630646 189 Human hsa_circ_0001313 circRNA X-rays colorectal cancer (CRC) SW480 and SW620 cells 6-MV X-ray exposure Radiation treatment in colon cells triggered a remarkable upregulation of circ_0001313 and a downregulated of miR-338-3p. 30630646 190 Human hsa_circ_000139 circRNA XAV939 non-small cell lung cancer (NSCLC) NCL-H1299?cells XAV939 treatment "Circ_MDM2_000139, Circ_ATF2_001418, Circ_CDC25C_002079, and Circ_BIRC6_001271 Are Involved in the Functions of XAV939 in Non-Small Cell Lung Cancer" 31885751 191 Human hsa_circ_0001445 circRNA oxidized low density lipoprotein (ox-LDL) inflammatory injury human umbilical vein endothelial cells (HUVECs) oxidized low-density lipoprotein (ox-LDL) treatment Hsa_ circ_0001445 expression was gradually decreased with the increase of OX-LDL concentration. 33300444 192 Human hsa_circ_0001535 circRNA microcystin-leucine arginine (MC-LR) hepatotoxicity human normal liver cell line (HL7702) MC-LR exposure upregulated 31825292 193 Human hsa_circ_0001946 circRNA cisplatin (DDP) non-small cell lung cancer (NSCLC) "human normal lung fibroblasts cell line MRC-5, human NSCLC cell line A549, cisplatin-resistant cell line A549/DDP" cisplatin treatment hsa_circ_0001946 can affect the sensitivity of NSCLC cells to the chemotherapeutic drug cisplatin via modulation of the NER signaling pathway. 31249811 194 Human hsa_circ_0001953 circRNA mycobacterium tuberculosis (Mtb) tuberculosis (TB) plasma Mycobacterium tuberculosis (Mtb) infection upregulated 30214434 195 Human hsa_circ_0002142 circRNA hypoxia glioblastoma multiforme (GBM) "The normal human astrocyte line SVGp12 and two human glioma cell lines, U87MG and A172" hypoxia induce upregulated 30988674 196 Human hsa_circ_0002317 circRNA high glucose (HG) diabetes-associated endothelial dysfunction human umbilical vein endothelial cells (HUVECs) ?high glucose (HG) induce treatment dysregulated 31369204 197 Human hsa_circ_0002468 circRNA retinoic acid (RA) human neuronal differentiation SH-SY5Y cells retinoic acid (RA) treatment The expression of hsa_circ_0002468 was increased during SH-SY5Y differentiation and was inversely correlated with miR-561 expression. 30951518 198 Human hsa_circ_0002570 circRNA high glucose (HG) diabetic retinopathy (DR) human retinal microvascular endothelial cells (hRMECs) high glucose treatment circ_0002570 could upregulate angiomotin by targeting miR-1243 to mediate the dysfunction of hRMECs induced by high glucose. 32319024 199 Human hsa_circ_0002594 circRNA corticosteroid allergic asthma (AA) CD4+ T cells inhaled corticosteroids (ICS) treatment Hsa_circ_0002594 was decreased after inhaled corticosteroids (ICS) treatment. 33326955 200 Human hsa_circ_0002755 circRNA sevoflurane (SEV) glioblastoma multiforme (GBM) A-172; SHG-44 Sevoflurane (Sev) treatment Sev mediated glioma progression via circ_0002755/miR-628-5p/MAGT1 axis 32669871 201 Human hsa_circ_0003204 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human aorta endothelial cells (HAECs) oxidized low-density lipoprotein (ox-LDL) treatment upregulated 31900142 202 Human hsa_circ_0003247 circRNA microcystin-leucine arginine (MC-LR) hepatotoxicity human normal liver cell line (HL7702) MC-LR exposure upregulated 31825292 203 Human hsa_circ_0003250 circRNA high glucose (HG) diabetes-associated endothelial dysfunction human umbilical vein endothelial cells (HUVECs) ?high glucose (HG) induce treatment dysregulated 31369204 204 Human hsa_circ_0003418 circRNA cisplatin (DDP) hepatocellular carcinoma (HCC) "Human HCC cell lines (Hep-3B, Huh-7, Sk-hep-1, SMMC7721 and PLC)" cisplatin treatment suppression of circ_0003418 enhanced cisplatin resistance of HCC cells in vivo and vitro. 31807029 205 Human hsa_circ_0003420 circRNA lipopolysaccharide (LPS) sepsis-induced liver injury Kupffer cells lipopolysaccharide (LPS) treatment We observed circ_0003420 upregulation accompanied by NPAS4 downregulated in liver samples from patients with sepsis-associated damage and in Kupffer cells treated with LPS. 33719821 206 Human hsa_circ_0003489 circRNA hypoxia osteogenesis periodontitis tissues hypoxia treatment "The expression levels of circCDK8 and hypoxia-inducible factor-1¦Á were significantly increased in periodontitis tissues, and the expression of circCDK8 was further confirmed in a hypoxia model using cobalt chloride (CoCl2?)." 32978798 207 Human hsa_circ_0003524 circRNA mycobacterium tuberculosis (Mtb) tuberculosis (TB) plasma Mycobacterium tuberculosis (Mtb) infection upregulated 30214434 208 Human hsa_circ_0003528 circRNA mycobacterium tuberculosis (Mtb) tuberculosis (TB) plasma Mycobacterium tuberculosis (Mtb) infection upregulated 30214434 209 Human hsa_circ_0003546 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human THP-1 macrophages oxidized low-density lipoprotein (ox-LDL) treatment dysregulated 31804889 210 Human hsa_circ_0003575 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) HUVECs oxidized low-density lipoprotein (ox-LDL) treatment upregulated 28946214 211 Human hsa_circ_0003645 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human umbilical vein endothelial cells (HUVECs) oxidized low-density lipoprotein (ox-LDL) treatment upregulated 32554046 212 Human hsa_circ_0003865 circRNA melatonin osteoporosis human bone marrow mesenchymal stem cell (hBMSC) melatonin (MEL) treatment Circ_0003865 expression in BMSCs was significantly decreased by MEL treatment. 33632317 213 Human hsa_circ_0003928 circRNA high glucose (HG) diabetic nephropathy (DN) HK-2 cells high glucose (HG) treatment Hsa_circ_0003928 was increased in HG-induced HK-2 cells. 32982348 214 Human hsa_circ_0004018 circRNA salvianolic acid B (Sal B) liver fibrosis hepatic stellate cells (HSCs) salvianolic acid B treatment Hsa_circ_0004018 were significantly upregulated over time as the HSCs were treated with 100 ug/L of Sal B 32584784 215 Human hsa_circ_0004018 circRNA salvianolic acid B (Sal B) liver fibrosis primary hepatic stellate cells (HSCs) salvianolic acid B treatment hsa_circ_0004018 were significantly upregulated over time as the HSCs were treated with 100 ug/L of Sal B 32584784 216 Human hsa_circ_0004058 circRNA H2O2 age-related cataract (ARC) human lens epithelial B3 (HLE-B3) cells H2O2 treatment Our data showed that circZNF292 was downregulated in ARC tissues and H2O2-treated human lens epithelial B3 (HLE-B3) cells. 33851769 217 Human hsa_circ_0004812 circRNA hepatitis B virus (HBV) chronic hepatitis B virus (HBV) infection Huh7 cells; HepG2 cells pHBV1.3 infection The level of circ_0004812 was significantly increased in the pHBV1.3-infected cells. 32188476 218 Human hsa_circ_0004872 circRNA platelet derived growth factor-BB (PDGF-BB) atherosclerosis (AS) human aortic vascular smooth muscle cells (HA-VSMCs) platelet derived growth factor-BB (PDGF-BB)?treatment treatment Circ_0004872 expression was elevated in PDGF-BB-induced human aortic vascular smooth muscle cells (HA-VSMCs) and carotid plaque tissues 33592319 219 Human hsa_circ_0004916 circRNA IFN-¦Ã epithelial-mesenchymal transition (EMT) PC-3M IE8 cells interferon-¦Ã (IFN-¦Ã) treatment downregulated in PC-3M IE8 cells in the EMT induction model 31882179 220 Human hsa_circ_0004916 circRNA IFN-¦Ã epithelial-mesenchymal transition (EMT) PC-3M IE8 cells IFN-¦Ã treatment downregulated 31882179 221 Human hsa_circ_0005105 circRNA IL-1¦Â osteoarthritis (OA) human Chondrocytes-articular IL-1¦Â treatment upregulated 28276108 222 Human hsa_circ_0005263 circRNA high glucose (HG) diabetes-associated endothelial dysfunction human umbilical vein endothelial cells (HUVECs) ?high glucose (HG) induce treatment dysregulated 31369204 223 Human hsa_circ_0005694 circRNA 5-fluorouracil (5-Fu) osteosarcoma (OS) MG63 cells 5-fluorouracil (5-FU) treatment downregulated 33308021 224 Human hsa_circ_0005741 circRNA high glucose (HG) diabetes-associated endothelial dysfunction human umbilical vein endothelial cells (HUVECs) ?high glucose (HG) induce treatment dysregulated 31369204 225 Human hsa_circ_0005941 circRNA cisplatin (DDP) non-small cell lung cancer (NSCLC) A549 cells cisplatin treatment downregulated 32767026 226 Human hsa_circ_0005963 circRNA oxaliplatin colorectal cancer (CRC) SW480 cells; HCT116 cells oxaliplatin treatment upregulated 31901148 227 Human hsa_circ_0006294 circRNA sorafenib (SOR) hepatocellular carcinoma (HCC) Huh-7 cells; HepG2 cells sorafenib treatment downregulated 32226514 228 Human hsa_circ_0006393 circRNA dexamethasone (DEX) glucocorticoid-induced osteoporosis (GIOP) Bone tissue dexamethasone (DEX) treatment "the expression level of hsa_circ_0006393 was decreased in patients with GIOP. Furthermore, the overexpression of hsa_circ_0006393 increased the expression level of genes associated with osteogenesis." 31322188 229 Human hsa_circ_0006766 circRNA ultraviolet (UV) irradiation photoaging human dermal fibroblasts (HDFs) ultraviolet A (UVA)-irradiated treatment downregulated 33093901 230 Human hsa_circ_0006867 circRNA gefitinib non-small cell lung cancer (NSCLC) HCC827 cells; PC9 cells gefitinib treatment downregulated 32328186 231 Human hsa_circ_0006872 circRNA cigarette smoke extract (CSE) chronic obstructive pulmonary disease (COPD) Human pulmonary microvascular endothelial cells HPMECs and bronchial epithelial cells BEAS-2B cigarette smoke extract (CSE) treatment upregulated 33248690 232 Human hsa_circ_0006872 circRNA cigarette smoke extract (CSE) chronic obstructive pulmonary disease (COPD) HPMECs and BEAS-2B cells cigarette smoke extract (CSE) exposure "Hsa_circ_0006872 facilitated CSE-triggered apoptosis, inflammation and oxidative stress in HPMECs and BEAS-2B cells by regulating miR-145-5p/NF-¦ÊB pathway." 33248690 233 Human hsa_circ_0006892 circRNA cigarette smoke extract (CSE) chronic obstructive pulmonary disease (COPD) The bronchial epithelial cells (BEAS-2B and 16HBE) cigarette smoke extract (CSE) treatment Circ_0006892 expression was reduced in lung tissues of smokers with COPD and CSE-stimulated bronchial epithelial cells. 33734482 234 Human hsa_circ_0007006 circRNA 5-fluorouracil (5-Fu) colorectal cancer (CRC) "human CRC cell line, HCT116" 5-fluorouracil (5-FU) treatment upregulated 28656150 235 Human hsa_circ_0007031 circRNA 5-fluorouracil (5-Fu) colorectal cancer (CRC) "human CRC cell line, HCT116" 5-fluorouracil (5-FU) treatment upregulated 28656150 236 Human hsa_circ_0007031 circRNA 5-fluorouracil (5-Fu) colorectal cancer (CRC) HCT116 cells; Caco2 cells 5-fluorouracil (5-FU) treatment Circ_0007031 expression was markedly increased in CRC resistant cells. 32982440 237 Human hsa_circ_0007386 circRNA 5-fluorouracil (5-Fu) osteosarcoma (OS) MG63 cells 5-fluorouracil (5-FU) treatment downregulated 33308021 238 Human hsa_circ_0007623 circRNA hypoxia myocardial ischaemic injury human umbilical vein endothelial cells (HUVECs) hypoxia treatment "hsa_circ_0007623 can bind to miR-297, promote cardiac repair after acute myocardial ischemia, and protect cardiac function." 31973814 239 Human hsa_circ_0007976 circRNA high glucose (HG) diabetes-associated endothelial dysfunction human umbilical vein endothelial cells (HUVECs) ?high glucose (HG) induce treatment dysregulated 31369204 240 Human hsa_circ_0008285 circRNA high glucose (HG) gestational diabetes mellitus (GDM) HTR-8 cellsS;Vneo cells high-glucose (HG) treatment "In GDM patients, the expression of circ_0008285 was significantly upregulated, while that of circ_0001173 was decreased." 33879262 241 Human hsa_circ_0008297 circRNA mycobacterium tuberculosis (Mtb) tuberculosis (TB) plasma Mycobacterium tuberculosis (Mtb) infection upregulated 30214434 242 Human hsa_circ_0008305 circRNA TGF-¦Â1 non-small cell lung cancer (NSCLC) A549 cells; H226 cells TGF-¦Â1 treatment circ_0008305 was significantly downregulated in NSCLC cells undergoing EMT induced by TGF-¦Â 30261900 243 Human hsa_circ_0008360 circRNA high glucose (HG) diabetes-associated endothelial dysfunction human umbilical vein endothelial cells (HUVECs) ?high glucose (HG) induce treatment dysregulated 31369204 244 Human hsa_circ_0008362 circRNA 5-fluorouracil (5-Fu) osteosarcoma (OS) MG63 cells 5-fluorouracil (5-FU) treatment downregulated 33308021 245 Human hsa_circ_0008450 circRNA hypoxia hepatocellular carcinoma (HCC) SNU-387 cells; Huh7 cells hypoxia treatment Circ_0008450 was upregulated in hypoxia-disposed HCC cells. 33193848 246 Human hsa_circ_0009024 circRNA mycobacterium tuberculosis (Mtb) tuberculosis (TB) plasma Mycobacterium tuberculosis (Mtb) infection upregulated 30214434 247 Human hsa_circ_000926 circRNA gemcitabine (GEM) pancreatic cancer (PC) SWl990 cells gemcitabine (GEM) treatment downregulated 29781033 248 Human hsa_circ_0009910 circRNA imatinib chronic myeloid leukemia (CML) K562 cells; serum imatinib treatment The expression of circ_0009910 was upregulated in the serum of imatinib-resistance CML patients and K562/R cells. 31923418 249 Human hsa_circ_0010283 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human vascular smooth muscle cells (VSMCs) oxidized low-density lipoprotein (ox-LDL) treatment circ_0010283 mediated cell viability and migration via a miR-370-3p/HMGB1 axis in ox-LDL-induced VSMCs. 32945389 250 Human hsa_circ_0010283 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human VSMCs (HVSMCs) oxidized low-density lipoprotein (ox-LDL) treatment circ_0010283 participated in ox-LDL-induced dysfunctions of HVSMCs by modulating the miR-133a-3p/PAPPA pathway. 33162460 251 Human hsa_circ_0010729 circRNA hypoxia ischemic heart disease (IHD) AC16 cell hypoxia exposure circ_0010729 knockdown alleviated hypoxia-induced AC16 cell injuries by mediating the miR-27a-3p/TRAF5 axis. 33010282 252 Human hsa_circ_0010729 circRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic heart disease (IHD) human cardiomyocytes (HCM) oxygen-glucose deprivation and reoxygenation (OGD/R) treatment "OGD treatment enhanced circ_0010729 expression and evoked cell injury in HCM Moreover, OGD-induced injury was aggrandized by circ_0010729 overexpression via suppressing cell growth and migration in HCM" 31482388 253 Human hsa_circ_0010729 circRNA hypoxia "vascular endothelial cell proliferation , apoptosis" human umbilical vein endothelial cells (HUVECs) hypoxia treatment upregulated 28571741 254 Human hsa_circ_0011129 circRNA ultraviolet (UV) irradiation photoaging human dermal fibroblasts (HDFs) ultraviolet A (UVA)-irradiated treatment downregulated 33093901 255 Human hsa_circ_00116639 circRNA 5-fluorouracil (5-Fu) osteosarcoma (OS) MG63 cells 5-fluorouracil (5-FU) treatment upregulated 33308021 256 Human hsa_circ_001175 circRNA high glucose (HG) high glucose (HG) disease human umbilical vein endothelial cells (HUVECs) high glucose (HG) treatment Glucose treatments gradually decreased the expressions of circRNA-001175 in a concentration dependent manner. 30521417 257 Human hsa_circ_0012129 circRNA sevoflurane (SEV) glioblastoma multiforme (GBM) T98G cell; LN229 cells sevoflurane (Sev) treatment Circ_0012129 was downregulated in sevoflurane-treated glioma cells 32495888 258 Human hsa_circ_001271 circRNA XAV939 non-small cell lung cancer (NSCLC) NCL-H1299?cells XAV939 treatment "Circ_MDM2_000139, Circ_ATF2_001418, Circ_CDC25C_002079, and Circ_BIRC6_001271 Are Involved in the Functions of XAV939 in Non-Small Cell Lung Cancer" 31885751 259 Human hsa_circ_001418 circRNA XAV939 non-small cell lung cancer (NSCLC) NCL-H1299?cells XAV939 treatment "Circ_MDM2_000139, Circ_ATF2_001418, Circ_CDC25C_002079, and Circ_BIRC6_001271 Are Involved in the Functions of XAV939 in Non-Small Cell Lung Cancer" 31885751 260 Human hsa_circ_0015879 circRNA mycobacterium tuberculosis (Mtb) tuberculosis (TB) plasma Mycobacterium tuberculosis (Mtb) infection upregulated 30214434 261 Human hsa_circ_0020394 circRNA puerarin bladder cancer T24 cells; UM-UC-3 cells puerarin treatment circ_0020394 was downregulated in puerarin-treated bladder cancer cells 33016781 262 Human hsa_circ_002079 circRNA XAV939 non-small cell lung cancer (NSCLC) NCL-H1299?cells XAV939 treatment "Circ_MDM2_000139, Circ_ATF2_001418, Circ_CDC25C_002079, and Circ_BIRC6_001271 Are Involved in the Functions of XAV939 in Non-Small Cell Lung Cancer" 31885751 263 Human hsa_circ_0026344 circRNA CCL20 and CXCL8 colorectal cancer (CRC) human CRC cell lines SW480 and Caco-2 ?CCL20 and CXCL8 co-stimulation "Highlights CCL20 and CXCL8 synergize to decrease the expression of circ_0026344; Silence of circ_0026344 promotes CRC cells migration, invasion and EMT process" 31608699 264 Human hsa_circ_0027492 circRNA doxorubicin (DOX) DNA damage HCT116 cells; RKO cells; SW48 cells Doxorubicin (DOXO) treatment Hsa_circ_0027492 is upregulated in a p53-dependent manner in response to DNA damage. 32041821 265 Human hsa_circ_0028198 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human THP-1 macrophages oxidized low-density lipoprotein (ox-LDL) treatment dysregulated 31804889 266 Human hsa_circ_0029589 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human vascular smooth muscle cells (VSMCs) oxidized low-density lipoprotein (ox-LDL) treatment Circ_0029589 silence might inhibit the progression of AS by regulating miR-424-5p/IGF2 axis 32860985 267 Human hsa_circ_0030411 circRNA cisplatin (DDP) non-small cell lung cancer (NSCLC) A549 cells cisplatin treatment upregulated 32767026 268 Human hsa_circ_0031250 circRNA genistein non-small cell lung cancer (NSCLC) human NSCLC cell lines (H292 and A549) genistein treatment "circ_0031250 abundance was elevated in NSCLC samples and cell lines, and it was reduced via genistein exposure." 33159503 269 Human hsa_circ_0031250 circRNA genistein non-small cell lung cancer (NSCLC) H292 cells; A549 cells Genistein treatment "circ_0031250 abundance was elevated in NSCLC samples and cell lines, and it was reduced via genistein exposure." 33159503 270 Human hsa_circ_003211 circRNA curcumin (Cur) nasopharyngeal carcinoma (NPC) CNE-2R cells curcumin treatment downregulated 31793078 271 Human hsa_circ_003251 circRNA gemcitabine (GEM) pancreatic cancer (PC) SWl990 cells gemcitabine (GEM) treatment upregulated 29781033 272 Human hsa_circ_0032821 circRNA oxaliplatin gastric cancer (GC) HGC-27 cells; AGS cells oxaliplatin (OXA) treatment Circ_0032821 was highly expressed in OXA-resistant GC cells 33123829 273 Human hsa_circ_0034616 circRNA 5-fluorouracil (5-Fu) osteosarcoma (OS) MG63 cells 5-fluorouracil (5-FU) treatment upregulated 33308021 274 Human hsa_circ_0035266 circRNA 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and lipopolysaccharide (LPS) inflammation BEAS-2B cells 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and lipopolysaccharide (LPS) treatment "We identified a novel circRNA, circ_0035266, which was strongly upregulated in NNK+LPS-induced BEAS-2B cells and enhanced the inflammatory responses to NNK+LPS by regulating the secretion of pro-inflammatory cytokines interleukin (IL)-6 and IL-8." 33107911 275 Human hsa_circ_0035483 circRNA gemcitabine (GEM) renal cell carcinoma (RCC) renal tissues or TK10 and UO31 cells gemcitabine treatment "Hsa_circ_0035483 can facilitate gemcitabine-induced autophagy, and enhance the resistance of RCC to gemcitabine." 31492499 276 Human hsa_circ_0035944 circRNA sorafenib (SOR) hepatocellular carcinoma (HCC) Huh-7 cells; HepG2 cells sorafenib treatment downregulated 32226514 277 Human hsa_circ_0038467 circRNA lipopolysaccharide (LPS) pneumonia 16HBE cells lipopolysaccharide (LPS) treatment Circ_0038467 was upregulated and miR-338-3p was downregulated in LPS-treated 16HBE cells. 32181994 278 Human hsa_circ_0039411 circRNA neodymium oxide (Nd2O3) inflammation human bronchial epithelial cells (16HBE) neodymium oxide (Nd2O3) treatment upregulation of circ_0039411 mediated Nd2O3-induced inflammation and dysfunction by sponging miR-93-5p. 30903189 279 Human hsa_circ_0040768 circRNA caffeic acid phenethyl ester (CAPE) cadmium-induced toxicity HepG2 cells caffeic acid phenethyl ester (CAPE) treatment "CAPE significantly (P < 0.05) increased cell viability via inhibiting CdCl2-induced autophagy, and this process was regulated by hsa_circ_0040768/MAP1LC3B axis." 32298858 280 Human hsa_circ_004077 circRNA gemcitabine (GEM) pancreatic cancer (PC) SWl990 cells gemcitabine (GEM) treatment upregulated 29781033 281 Human hsa_circ_0040824 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human umbilical vein endothelial cells (HUVECs) oxidized low-density lipoprotein (ox-LDL) treatment Our data showed that circ-BANP expression was upregulated in AS blood and ox-LDL-induced HUVECs. 33298736 282 Human hsa_circ_0041795 circRNA high glucose (HG) diabetic retinopathy (DR) ARPE-19 cells high glucose (HG) treatment hsa_circ_0041795 contributes to human retinal pigment epithelial cells (ARPE 19) injury induced by high glucose via sponging miR-646 and activating VEGFC 32259632 283 Human hsa_circ_0043256 circRNA cinnamaldehyde (CA) non-small cell lung cancer (NSCLC) NCI-H460;A549 cell lines Cinnamaldehyde (CA) treatment upregulated 28958934 284 Human hsa_circ_0043497 circRNA mycobacterium tuberculosis (Mtb) tuberculosis (TB) human monocyte derived macrophages (MDMs) infect with Mtb dysregulated 29057952 285 Human hsa_circ_0044073 circRNA lipopolysaccharide (LPS) atherosclerosis (AS) Human umbilical vein endothelial cells (HUVECs) and human umbilical vein smooth muscle cells (HUVSMCs) lipopolysaccharide (LPS) treatment LPS treatment significantly increased the levels of circRNA-0044073 in HUVSMCs but downregulated the levels of circRNA-0044073 in HUVECs. CircRNA-0044073 activates the JAK/STAT signaling pathway of HUVSMCs and HUVECs. 30864721 286 Human hsa_circ_0044226 circRNA TGF-¦Â1 idiopathic pulmonary fibrosis (IPF) The human lung fibroblasts (WI-38 cells) TGF-¦Â1 treatment upregulated 31786325 287 Human hsa_circ_0045462 circRNA high glucose (HG) diabetes-associated endothelial dysfunction human umbilical vein endothelial cells (HUVECs) ?high glucose (HG) induce treatment dysregulated 31369204 288 Human hsa_circ_0046366 circRNA free fatty acids (FFAs; 2:1 oleate:palmitate) hepatocellular steatosis HepG2 cells free fatty acids (FFAs; 2:1 oleate:palmitate) treatment downregulated 29391755 289 Human hsa_circ_0047814 circRNA H2O2 diabetic retinopathy (DR) ACBRI-183 cells H2O2 treatment upregulated 32343678 290 Human hsa_circ_0047814 circRNA high glucose (HG) diabetic retinopathy (DR) ACBRI-183 cells high glucose (HG) treatment upregulated 32343678 291 Human hsa_circ_0047814 circRNA IL-6 diabetic retinopathy (DR) ACBRI-183 cells IL-6?treatment upregulated 32343678 292 Human hsa_circ_0047814 circRNA tumor necrosis factor alpha (TNF-¦Á) diabetic retinopathy (DR) ACBRI-183 cells tumor necrosis factor alpha (TNF-¦Á) treatment upregulated 32343678 293 Human hsa_circ_0047814 circRNA vascular endothelial growth factor (VEGF) diabetic retinopathy (DR) ACBRI-183 cells VEGF treatment upregulated 32343678 294 Human hsa_circ_0054633 circRNA high glucose (HG) endothelial dysfunction human umbilical vein endothelial cells (HUVECs) high glucose (HG) treatment upregulated 29693114 295 Human hsa_circ_0058097 circRNA excessive mechanical tension intervertebral disc degeneration (IDD) primary human endplate chondrocytes culture Excessive mechanical tension induce "circRNA_0058097 can upregulate the expression of downstream target gene histone deacetylase 4 by sponge adsorption of miR-365a-5p, which promoted morphological changes of endplate chondrocytes, and increased extracellular matrix degradation and degeneration of endplate cartilage." 31222836 296 Human hsa_circ_0060060 circRNA cisplatin (DDP) anaplastic thyroid carcinoma (ATC) TPC1 cells; BHT101 cells cisplatin (DPP) treatment upregulated 30540564 297 Human hsa_circ_0060927 circRNA vitamin D vitamin D metabolism HCT-116; HT-29 cells vitamin D treatment upregulated 32803502 298 Human hsa_circ_0061012 circRNA IL-22 psoriasis HaCaT cells IL-22 treatment Interleukin-22 (IL-22) treatment increased the expression of circ_0061012 in a dose-dependent manner. 33393621 299 Human hsa_circ_0061052 circRNA cigarette smoke (CS) epithelial-mesenchymal transition (EMT) human bronchial epithelial (HBE) cells Cigarette smoke (CS) exposure upregulated 32768781 300 Human hsa_circ_0063809 circRNA paclitaxel (PTX) ovarian cancer (OC) SKOV3 cells; HeyA-8 cells paclitaxel (PTX) treatment The expression of circ_0063809 in PTX-resistant ovarian cancer cells (SKOV3/PTX and HeyA-8/ PTX) was upregulated 31945729 301 Human hsa_circ_0063809 circRNA paclitaxel (PTX) ovarian cancer (OC) ovarian cancer cells (SKOV3/PTX and HeyA-8/PTX) paclitaxel (PTX) treatment "circCELSR1 was highly expressed in PTX-resistant ovarian cancer cell lines, and circCELSR1 silencing enhanced PTX-induced cytotoxicity in ovarian cancer cells" 31945729 302 Human hsa_circ_0064772 circRNA high glucose (HG) diabetes-associated endothelial dysfunction human umbilical vein endothelial cells (HUVECs) ?high glucose (HG) induce treatment dysregulated 31369204 303 Human hsa_circ_006660 circRNA curcumin (Cur) nasopharyngeal carcinoma (NPC) CNE-2R cells curcumin treatment upregulated 31793078 304 Human hsa_circ_0067717 circRNA hepatitis B virus (HBV) hepatocellular carcinoma (HCC) Huh7-HBV;Hep3B-HBV cells hepatitis B virus (HBV) infection "Circ-RNF13 was upregulated in HBV-infected human HCC tissues and HBV-expressing cells (Huh7-HBV and Hep3B-HBV), accompanied with TGIF2 upregulation and miR-424-5p downregulated." 33714261 305 Human hsa_circ_0068087 circRNA high glucose (HG) diabetes mellitus (DM) human umbilical vein endothelial cells (HUVECs) high glucose (HG) treatment upregulated 31108165 306 Human hsa_circ_0068655 circRNA hypoxia myocardial infarction (MI) human induced pluripotent stem-derived cardiomyocytes (HCMs) hypoxia treatment Circ_0068655 Promotes Cardiomyocyte Apoptosis via miR-498/PAWR Axis 32767028 307 Human hsa_circ_0068888 circRNA lipopolysaccharide (LPS) acute kidney injury (AKI) Human renal proximal tubular cell line HK-2 lipopolysaccharide (LPS) treatment Decreased hsa_circ_0068888 expression was observed in AKI cell model. 33429194 308 Human hsa_circ_00699 circRNA "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine)" cell differentiation 5-aza induced the differentiation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) into cardiomyocyte-like cells "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine) treatment" downregulated 30756390 309 Human hsa_circ_0073237 circRNA radiation glioblastoma multiforme (GBM) U87 cells; U251 cells radiation treatment circ_VCAN expression was significantly downregulated in U87 and U251 cells following irradiation 32080097 310 Human hsa_circ_0073817 circRNA 5-fluorouracil (5-Fu) osteosarcoma (OS) MG63 cells 5-fluorouracil (5-FU) treatment downregulated 33308021 311 Human hsa_circ_0076305 circRNA cisplatin (DDP) non-small cell lung cancer (NSCLC) "NSCLC tissues and cells (A549, H1650, A549/DDP, H1650/DDP)" cisplatin treatment upregulated 31647948 312 Human hsa_circ_0076631 circRNA high glucose (HG) diabetic cardiomyopathy (DCM) AC16 cells high glucose treatment circRNA-0076631 was increased both in high-glucose-treated cardiomyocytes and in the serum of diabetic patients. 31400606 313 Human hsa_circ_0077930 circRNA high glucose (HG) vascular smooth muscle aging human umbilical vein endothelial cell (HUVEC) high glucose (HG) treatment HG-HUVECs derived exosomes induced the VSMCs senescence by circRNA0077930-miR622-Kras CeRNA network. 32307741 314 Human hsa_circ_007874 circRNA monastrol breast cancer MCF-7 cells; MDA-MB-231 cells monastrol treatment circRNA-MTO1 (hsa-circRNA-007874) was validated as a circRNA that exhibited elevated expression levels in monastrol-resistant cells. 30015883 315 Human hsa_circ_0079662 circRNA oxaliplatin colorectal cancer (CRC) HT29 cells; HCT116 cells; HCT8 cells oxaliplatin treatment "hsa_circ_0079662, as a ceRNA binding with hsa-mir-324-5p, can regulate target gene HOXA9 and induced the mechanism of chemotherapy drug oxaliplatin resistance in CRC through the TNF-¦Á pathway in human colon cancer" 32243061 316 Human hsa_circ_0081001 circRNA doxorubicin (DOX) osteosarcoma (OS) MG63 cells; KHOS cells; U2OS cells doxorubicin (Dox) treatment hsa_circ_0081001 was upregulated with 12 fold change in the chemo-resistant OS cell lines. 30263004 317 Human hsa_circ_0084043 circRNA high glucose (HG) diabetic retinopathy (DR) ARPE-19 cells high glucose (HG) treatment Loss of circRNA_0084043 depressed HG-induced damage via sponging miR-140-3p and regulating TGFA. 32259630 318 Human hsa_circ_0086720 circRNA radiation non-small cell lung cancer (NSCLC) non-small cell lung cancer (NSCLC) tissues radiation treatment upregulated 32940043 319 Human hsa_circ_0088364 circRNA nitidine chloride (NC) hepatocellular carcinoma (HCC) HCC xenograft tumour tissues Nitidine chloride (NC)?treatment hsa_circ_0088364 dysregulated. 31506425 320 Human hsa_circ_008913 circRNA arsenite arsenite-induced carcinogenesis HaCaT cells arsenite exposure downregulated 30167605 321 Human hsa_circ_0090049 circRNA nitidine chloride (NC) hepatocellular carcinoma (HCC) HCC xenograft tumour tissues Nitidine chloride (NC)?treatment hsa_circ_0090049 dysregulated. 31506425 322 Human hsa_circ_0091223 circRNA ¦Á-melanocyte-stimulating hormone (¦Á-MSH) skin pigmentation disorders human skin primary melanocytes (MCs) ¦Á-MSH treatment upregulated 33318297 323 Human hsa_circ_0092317 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human THP-1 macrophages oxidized low-density lipoprotein (ox-LDL) treatment dysregulated 31804889 324 Human hsa_circ_0092493 circRNA hepatitis B virus (HBV) hepatocellular carcinoma (HCC) serum hepatitis B virus (HBV) infection "?In this study, we performed circRNA microarray profile and found an HBV-related circRNA, circ-ARL3 (hsa_circ_0092493)." 33372396 325 Human hsa_circ_0096157 circRNA cisplatin (DDP) non-small cell lung cancer (NSCLC) A549 cells cisplatin treatment upregulated 32767026 326 Human hsa_circ_0109320 circRNA gefitinib non-small cell lung cancer (NSCLC) plasma gefitinib treatment Elevated hsa_circ_0109320 was associated with longer PFS in gefitinib-treated NSCLC patients. hsa_circ_0109320 may be a potential biomarker for the efficacy of EGFR-TKI in NSCLC patients. 31285870 327 Human hsa_circ_0110805 circRNA cisplatin (DDP) gastric cancer (GC) AGS cells; HGC-27 cells cisplatin (DPP) treatment "circ_0110805 knockdown increased the sensitivity of gastric cancer to cisplatin, which also repressed gastric cancer progression by sponging miR-299-3p to downregulate ENDOPDI expression." 33192077 328 Human hsa_circ_0113656 circRNA platelet derived growth factor-BB (PDGF-BB) vascular restenosis human aortic vascular smooth muscle cell (HA-VSMC) platelet derived growth factor-BB (PDGF-BB) treatment upregulated 32736703 329 Human hsa_circ_0114427 circRNA gentamicin acute kidney injury (AKI) HK-2 cells gentamicin treatment "Circ-0114427 dramatically increased 727 in LPS-, H202-, and gentamicin-induced AKI cell models." 31930399 330 Human hsa_circ_0114427 circRNA H2O2 acute kidney injury (AKI) HK-2 cells H2O2 treatment "Circ-0114427 dramatically increased 727 in LPS-, H202-, and gentamicin-induced AKI cell models." 31930399 331 Human hsa_circ_0114427 circRNA lipopolysaccharide (LPS) acute kidney injury (AKI) HK-2 cells LPS treatment "Circ-0114427 dramatically increased 727 in LPS-, H202-, and gentamicin-induced AKI cell models." 31930399 332 Human hsa_circ_0114428 circRNA lipopolysaccharide (LPS) acute kidney injury (AKI) Human renal proximal tubular cell line HK-2 lipopolysaccharide (LPS) treatment upregulated 33830389 333 Human hsa_circ_0114876 circRNA IL-1¦Â osteoarthritis (OA) CHON-001 cells IL-1¦Â treatment The expression of circ_0114876 was increased in OA tissues and inhibition of circ_0114876 could induce cell viability and suppress inflammation as well as inhibit cell apoptosis in IL-1¦Â induced CHON-001 cells. 33404903 334 Human hsa_circ_01183 circRNA "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine)" cell differentiation 5-aza induced the differentiation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) into cardiomyocyte-like cells "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine) treatment" downregulated 30756390 335 Human hsa_circ_0124644 circRNA oxidized low density lipoprotein (ox-LDL) atherosclerosis (AS) human vascular endothelial cells (HUVECs) oxidized low-density lipoprotein (ox-LDL) treatment Circular RNA circ_0124644 exacerbates the ox-LDL-induced endothelial injury in human vascular endothelial cells through regulating PAPP-A by acting as a sponge of miR-149-5p. 32500475 336 Human hsa_circ_0127305 circRNA 1-methyl-4-phenylpyridinium (MPP+) parkinson's disease (PD) SH-SY5Y cells 1-methyl-4-phenylpyridinium (MPP+) treatment upregulated 29953413 337 Human hsa_circ_0127305 circRNA pramipexole (PPX) parkinson's disease (PD) 1-methyl-4-phenylpyridinium (MMP+) treated SH-SY5Y cells pramipexole (PPX) treatment downregulated 29953413 338 Human hsa_circ_0134111 circRNA IL-1¦Â osteoarthritis (OA) human chondrocytes IL-1¦Â treatment Circ_0134111 was overexpressed in OA cartilage tissues and IL-1¦Â-induced chondrocytes. 33684877 339 Human hsa_circ_0134501 circRNA gefitinib non-small cell lung cancer (NSCLC) plasma gefitinib treatment dysregulated 31285870 340 Human hsa_circ_01536 circRNA "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine)" cell differentiation 5-aza induced the differentiation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) into cardiomyocyte-like cells "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine) treatment" upregulated 30756390 341 Human hsa_circ_01536 circRNA "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine)" cell differentiation 5-aza induced the differentiation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) into cardiomyocyte-like cells "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine) treatment" "Network analysis uncovered three potential key circRNAs, that is, circRNA_05432, circRNA_08441, and circRNA_01536." 30756390 342 Human hsa_circ_01978 circRNA "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine)" cell differentiation 5-aza induced the differentiation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) into cardiomyocyte-like cells "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine) treatment" downregulated 30756390 343 Human hsa_circ_04411 circRNA "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine)" cell differentiation 5-aza induced the differentiation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) into cardiomyocyte-like cells "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine) treatment" upregulated 30756390 344 Human hsa_circ_05432 circRNA "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine)" cell differentiation 5-aza induced the differentiation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) into cardiomyocyte-like cells "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine) treatment" "Network analysis uncovered three potential key circRNAs, that is, circRNA_05432, circRNA_08441, and circRNA_01536." 30756390 345 Human hsa_circ_08441 circRNA "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine)" cell differentiation 5-aza induced the differentiation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) into cardiomyocyte-like cells "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine) treatment" "Network analysis uncovered three potential key circRNAs, that is, circRNA_05432, circRNA_08441, and circRNA_01536." 30756390 346 Human hsa_circ_09169 circRNA "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine)" cell differentiation 5-aza induced the differentiation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) into cardiomyocyte-like cells "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine) treatment" upregulated 30756390 347 Human hsa_circ_09905 circRNA "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine)" cell differentiation 5-aza induced the differentiation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) into cardiomyocyte-like cells "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine) treatment" upregulated 30756390 348 Human hsa_circ_100284 circRNA arsenite acceleration of the cell cycle and carcinogenesis HaCaT cells arsenic exposure upregulated 28062277 349 Human hsa_circ_100284 circRNA arsenite bladder cancer Normal bladder SV-HUC-1 cells ?arsenite treatment "With prolonged contact time with arsenite, the expression level of circRNA-100284 in cells increased continuously" 33386469 350 Human hsa_circ_100284 circRNA arsenite cell cycle and proliferation human hepatic epithelial (L-02) cells arsenite exposure circRNA_100284 is involved in the malignant transformation of L-02 cells induced by arsenite. 29674685 351 Human hsa_circ_100338 circRNA hypoxia/reoxygenation (H/R) angiogenesis human umbilical vein endothelial cells (HUVECs) hypoxia/reoxygenation (H/R) treatment The expression of circ-100338 was decreased in HUAECs after H/R treatment. 32572929 352 Human hsa_circ_100797 circRNA ultraviolet (UV) irradiation cell senescence human fibroblast "the UVB irradiation output was monitored using a Waldmann UV meter (Waldmann, Villigen©\Schwenningen, Germany). UVB dose = UVB irradiance ¡Á time in second (s), with a distance of 15 cm between the lamp and cell culture dish. The UVB with 10 mJ/cm2 was delivered to cells daily for 5 days and at 48 hr after the last irradiation treatment" circRNA_100797 had a low expression in ultraviolet B stress-induced human fibroblast premature senescence (UVB-SIPS) 30908647 353 Human hsa_circ_101237 circRNA cisplatin (DDP) hepatocellular carcinoma (HCC) serum of patients; Huh7 cells cisplatin treatment upregulated 32226487 354 Human hsa_circ_101237 circRNA bortezomib multiple myeloma (MM) MM.1S cells; H929 cells bortezomib? treatment upregulated 32256118 355 Human hsa_circ_101505 circRNA cisplatin (DDP) hepatocellular carcinoma (HCC) The cisplatin-resistant Hep3B (Hep3B-R) and Huh7 (Huh7-R) cells cisplatin treatment "Gain-of-function investigations showed that overexpression of circRNA_101505 suppressed cancer cell growth in vivo and in vitro, and enhanced cisplatin toxicity in HCC cells." 31372241 356 Human hsa_circ_101543 circRNA gemcitabine (GEM) pancreatic cancer (PC) SWl990 cells gemcitabine (GEM) treatment downregulated 29781033 357 Human hsa_circ_101672 circRNA gemcitabine (GEM) pancreatic cancer (PC) SWl990 cells gemcitabine (GEM) treatment upregulated 29781033 358 Human hsa_circ_102115 circRNA curcumin (Cur) nasopharyngeal carcinoma (NPC) CNE-2 cells curcumin treatment "circ_102115 was upregulated in CNE-2 cells after treatment by radiation, while curcumin treatment downregulated the expression." 32127962 359 Human hsa_circ_102610 circRNA TGF-¦Â1 crohn disease (CD) human intestinal epithelial cells (HIECs); normal-derived colon mucosa cell line 460 (NCM460) cells TGF-¦Â1 treatment Hsa_circRNA_102610 upregulation in CD patients could promote the proliferation and EMT of intestinal epithelial cells via sponging of hsa-miR-130a-3p 32587447 360 Human hsa_circ_102747 circRNA gemcitabine (GEM) pancreatic cancer (PC) SWl990 cells gemcitabine (GEM) treatment downregulated 29781033 361 Human hsa_circ_103572 circRNA curcumin (Cur) nasopharyngeal carcinoma (NPC) CNE-2 cells curcumin treatment "circ_103572 was downregulated in CNE-2 cells after treatment by radiation, while curcumin treatment upregulated the expression." 32127962 362 Human hsa_circ_103765 circRNA tumor necrosis factor alpha (TNF-¦Á) crohn disease (CD) Caco2 and HIEC cells tumor necrosis factor alpha (TNF-¦Á) treatment upregulated 33436852 363 Human hsa_circ_103809 circRNA cisplatin (DDP) non-small cell lung cancer (NSCLC) A549 cells; H1299 cells cisplatin treatment upregulated 33276753 364 Human hsa_circ_104057 circRNA curcumin (Cur) nasopharyngeal carcinoma (NPC) CNE-2 cells curcumin treatment "circ_104057 was downregulated in CNE-2 cells after treatment by radiation, while curcumin treatment upregulated the expression." 32127962 365 Human hsa_circ_104075 circRNA matrine glioblastoma multiforme (GBM) Glioma cell line U251?cells Matrine treatment Matrine decreased circRNA-104075 expression significantly. Overexpression of circRNA-104075 was found to counteract the inhibitory effects of matrine on cell proliferation and promoting effects on apoptosis and autophagy in U251?cells. 31112718 366 Human hsa_circ_104250 circRNA particulate matter (PM2.5) airway inflammation "human bronchial epithelial cell line, BEAS-2B" particulate matter 2.5 (PM2.5) exosure treatment upregulated 31864925 367 Human hsa_circ_104250 circRNA particulate matter (PM2.5) airway inflammation "human bronchial epithelial cell line, BEAS-2B" particulate matter 2.5 (PM2.5) exposure treatment upregulated 31864925 368 Human hsa_circ_104883 circRNA curcumin (Cur) nasopharyngeal carcinoma (NPC) CNE-2R cells curcumin treatment downregulated 31793078 369 Human hsa_circ_13360 circRNA platelet derived growth factor-BB (PDGF-BB) atherosclerosis (AS) primary human aortic smooth muscle cells (HASMCs) platelet-derived growth factor (PDGF)-BB treatment upregulated 32547599 370 Human hsa_circ_14411 circRNA platelet derived growth factor-BB (PDGF-BB) atherosclerosis (AS) primary human aortic smooth muscle cells (HASMCs) platelet-derived growth factor (PDGF)-BB treatment upregulated 32547599 371 Human hsa_circ_16804 circRNA "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine)" cell differentiation 5-aza induced the differentiation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) into cardiomyocyte-like cells "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine) treatment" downregulated 30756390 372 Human hsa_circ_1698 circRNA platelet derived growth factor-BB (PDGF-BB) atherosclerosis (AS) primary human aortic smooth muscle cells (HASMCs) platelet-derived growth factor (PDGF)-BB treatment upregulated 32547599 373 Human hsa_circ_1848 circRNA platelet derived growth factor-BB (PDGF-BB) atherosclerosis (AS) primary human aortic smooth muscle cells (HASMCs) platelet-derived growth factor (PDGF)-BB treatment downregulated 32547599 374 Human hsa_circ_2858 circRNA escherichia coli (E.coli) meningitis human brain microvascular endothelial cells (hBMECs) escherichia coli (E. coli) infection circ_2858 was upregulated in human brain microvascular endothelial cells (hBMECs) upon meningitic E. coli infection. 33230468 375 Human hsa_circ_3041 circRNA platelet derived growth factor-BB (PDGF-BB) atherosclerosis (AS) primary human aortic smooth muscle cells (HASMCs) platelet-derived growth factor (PDGF)-BB treatment downregulated 32547599 376 Human hsa_circ_3046 circRNA herpes simplex virus 1 (HSV-1) herpes simplex virus 1 (HSV-1) infection KMB17 cells herpes simplex virus 1 (HSV-1) treatment upregulated 29972822 377 Human hsa_circ_3140 circRNA mechanical force (MF) osteogenesis human periodontal ligament stem cells (PDLSCs) mechanical force (MF)?induce "circRNA3140 was highly and widely associated with microRNA-21, which plays a critical role in MF-induced osteogenic differentiation of PDLSCs." 30422310 378 Human hsa_circ_33287 circRNA bone morphogenetic protein 2 (BMP2) cell differentiation maxillary sinus membrane stem cells (MSMSCs) bone morphogenetic protein 2 (BMP2) treatment Hsa_circRNA_33287 promotes the osteogenic differentiation of maxillary sinus membrane stem cells via miR-214-3p/Runx3. 30551425 379 Human hsa_circ_3875 circRNA platelet derived growth factor-BB (PDGF-BB) atherosclerosis (AS) primary human aortic smooth muscle cells (HASMCs) platelet-derived growth factor (PDGF)-BB treatment downregulated 32547599 380 Human hsa_circ_402801 circRNA curcumin (Cur) nasopharyngeal carcinoma (NPC) CNE-2 cells curcumin treatment "circ_402801 was upregulated in CNE-2 cells after treatment by radiation, while curcumin treatment downregulated the expression." 32127962 381 Human hsa_circ_403658 circRNA hypoxia bladder cancer hypoxia-induced 5637;T24 cells hypoxia-induce "hsa-circ_403658 was an important circRNA that upregulated in bladder cancer cells under hypoxia, and higher hsa-circ_403658 levels were associated with poorer survival outcome." 31814891 382 Human hsa_circ_406961 circRNA particulate matter (PM2.5) airway inflammation BEAS-2B cells Fine particulate matter (PM2.5) treatment "circ_406961 inhibited activation of STAT3/JNK pathways via interacting with ILF2 protein, thereby inhibiting the PM25-induced inflammatory reaction" 32388272 383 Human hsa_circ_4099 circRNA H2O2 hepatitis L02 cells H2O2 treatment circRNA-4099 was stimulated by H2O2. Plentiful circRNA-4099 augmented H2O2-resulted damage. 31479678 384 Human hsa_circ_4099 circRNA H2O2 hepatitis L02 cells H2O2 treatment upregulated 31479678 385 Human hsa_circ_4099 circRNA tumor necrosis factor alpha (TNF-¦Á) intervertebral disc degeneration (IDD) NP cells tumor necrosis factor alpha (TNF-¦Á) treatment TNF-¦Á treatment increased circ-4099 expression in NP cells 29651107 386 Human hsa_circ_4452 circRNA platelet derived growth factor-BB (PDGF-BB) atherosclerosis (AS) primary human aortic smooth muscle cells (HASMCs) platelet-derived growth factor (PDGF)-BB treatment upregulated 32547599 387 Human hsa_circ_51217 circRNA R-2-hydroxyglutarate (R-2HG) prostate cancer "C4-2, PC3, DU145, LNCaP cells" R-2-hydroxyglutarate (R-2HG) treatment upregulated 31846689 388 Human hsa_circ_5780 circRNA platelet derived growth factor-BB (PDGF-BB) atherosclerosis (AS) primary human aortic smooth muscle cells (HASMCs) platelet-derived growth factor (PDGF)-BB treatment downregulated 32547599 389 Human hsa_circ_6783 circRNA herpes simplex virus 1 (HSV-1) herpes simplex virus 1 (HSV-1) infection KMB17 cells herpes simplex virus 1 (HSV-1) treatment upregulated 29972822 390 Human hsa_circ_859267 circRNA ultraviolet (UV) irradiation photoaging human dermal fibroblasts (HDFs) UVA irradiated treatment downregulated 28286269 391 Human hsa_circ_8979 circRNA platelet derived growth factor-BB (PDGF-BB) atherosclerosis (AS) primary human aortic smooth muscle cells (HASMCs) platelet-derived growth factor (PDGF)-BB treatment upregulated 32547599 392 Human hsa_circ_9119 circRNA polyinosinic-polycytidilic acid (Poly(I:C)) orchitis testicular cells poly I:C treatment upregulated 31195953 393 Human hsa_circ_9119 circRNA IL-1¦Â osteoarthritis (OA) SW1353 cells IL-1¦Â treatment downregulated 32522568