ID Species ncRNA ncRNA type Environmental factor (EF) Phenotype Sample Condition of EF Evidence PubMed ID 1 Mouse chr15:95864225-95894541+ circRNA radiation radiation-induced injury jejuna radiation treatment upregulated 29991023 2 Mouse chr18:35610871-35613502+ circRNA radiation radiation-induced injury jejuna radiation treatment upregulated 29991023 3 Mouse chr19:16705875-16710941- circRNA radiation radiation-induced injury jejuna radiation treatment upregulated 29991023 4 Mouse chr19:42562552-42564341+ circRNA radiation radiation-induced injury jejuna radiation treatment downregulated 29991023 5 Mouse chr3:141922094:141940965 circRNA high glucose (HG) diabetic nephropathy (DN) Mouse primary kidney GEC (C57-6014G) and mouse glomerular mesangial cells (GMC) (SV40 MES 13) and derived exosomes high glucose (HG) treatment downregulated 31497190 6 Mouse chr3:72958113-72960367- circRNA radiation radiation-induced injury jejuna radiation treatment downregulated 29991023 7 Mouse chr3:96041338-96042928- circRNA radiation radiation-induced injury jejuna radiation treatment upregulated 29991023 8 Mouse chr5:32640331-32664400+ circRNA radiation radiation-induced injury jejuna radiation treatment downregulated 29991023 9 Mouse chr5:64096979-64108263+ circRNA radiation radiation-induced injury jejuna radiation treatment upregulated 29991023 10 Mouse chr8:79343654-79372364- circRNA radiation radiation-induced injury jejuna radiation treatment downregulated 29991023 11 Mouse circAkap7 circRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia injury (CII) primary astrocytes oxygen-glucose deprivation and reoxygenation (OGD/R) treatment Exosomes Derived From CircAkap7-Modified Adipose-Derived Mesenchymal Stem Cells Protect Against Cerebral Ischemic Injury 33123535 12 Mouse circARF3 circRNA high fat diet (HFD) adipose inflammation mouse adipose tissues high fat diet (HFD) feed Overexpressing TRAF3 attenuated miR-103-induced inflammation by accelerating mitophagy. 30623853 13 Mouse circArhgap12 circRNA doxorubicin (DOX) cardiotoxicity heart tissues doxorubicin (DOX) treatment CircRNA-Arhgap12 was upregulated in the mouse heart tissue upon DOX intervention. 33245966 14 Mouse circArhgap12 circRNA doxorubicin (DOX) doxorubicin (DOX)-induced cardiotoxicity heart tissue doxorubicin (DOX) treatment "we found that a circRNA coded by the Arhgap12 gene, termed circArhgap12, was upregulated in the mouse heart tissue upon DOX intervention. circArhgap12 might play a competitive role among endogenous RNAs in mouse cardiomyocytes during DOX-induced cardiotoxicity." 33245966 15 Mouse circATP9b circRNA carbon tetrachloride (CCl4) liver fibrosis hepatic stellate cells (HSCs) carbon tetrachloride (CCl4) treatment downregulated 32308754 16 Mouse circAtp9b circRNA IL-1¦Â osteoarthritis (OA) mouse chondrocytes IL-1¦Â treatment circRNA_Atp9b expression was significantly upregulated in mouse chondrocytes after stimulation with interleukin-1 beta (IL-1¦Â). 29305974 17 Mouse circBbs9 circRNA particulate matter (PM2.5) chronic obstructive pulmonary disease (COPD) lung tissues; blood; RAW264.7 cells Fine particulate matter (PM2.5) treatment upregulated 32707273 18 Mouse circCalm4 circRNA hypoxia hypoxic pulmonary hypertension (HPH) lung tissues hypoxia treatment 32008463 19 Mouse circCalm4 circRNA hypoxia pulmonary hypertension (PH) pulmonary arterial smooth muscle cells (PASMCs) hypoxia treatment upregulated 33657879 20 Mouse circCBFB circRNA acetaminophen (APAP) liver damage AML12 cells acetaminophen (APAP) treatment circ-CBFB acts as a miRNA sponge of miR-185-5p to mediate p66Shc in APAP-induced liver injury. 33159035 21 Mouse circCd84 circRNA tanshinone IIA (Tan IIA) atherosclerosis (AS) RAW 264.7 cells Tanshinone IIA (Tan) treatment downregulated 32337768 22 Mouse circCDH13 circRNA destabilization of medial meniscus (DMM) osteoarthritis (OA) artilage tissues destabilization of medial meniscus (DMM) treatment CircCDH13 contributes to OA pathogenesis by functioning as a sponge of miR-296-3p and regulating the miR-296-3p-PTEN pathway. 33037617 23 Mouse circCDR1as circRNA diosbuibin B (DB) gastric cancer (GC) "human gastric cancer cell lines (MGC803, BGC-823 and SGC7901)" diosbuibin B (DB) treatment knock-down of CircRNA CDR1as specifically promoted the cytotoxic effects of low-dose DB on GC cells instead of hepatocytes by regulating miR-7-5p/REG¦Ã axis. 31542615 24 Mouse circCOL1A2 circRNA streptozocin (STZ) diabetic retinopathy (DR) retinal tissues streptozotocin (STZ) treatment upregulated 32497630 25 Mouse circDcbld2 circRNA bisphenol A (BPA) apoptosis ?GC-2 cells bisphenol A (BPA) treatment upregulated 31020848 26 Mouse circDdx17 circRNA ovalbumin (OVA) allergic rhinitis (AR) spleen cells ovalbumin (OVA) treatment circDdx17 were decreased in OVA-induced AR mice. 31999672 27 Mouse circDLGAP4 circRNA "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)" parkinson's disease (PD) "ventral midbrains, mouse dopaminergic neuronal cell line MN9D" "1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) treatment" circDLGAP4 expression was decreased in MPTP-induced PD mouse model and MPP+-induced PD cell models. 31761328 28 Mouse circDLGAP4 circRNA "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)" parkinson's disease (PD) midbrain tissues "1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) treatment" circDLGAP4 expression was decreased in MPTP-induced PD mouse model. 31761328 29 Mouse circDYM circRNA chronic unpredictable mild stress (CUMS) depression plasma and hippocampus chronic unpredictable stress (CUS) treatment downregulated 30413800 30 Mouse circDYM circRNA lipopolysaccharide (LPS) depression plasma and hippocampus lipopolysaccharide (LPS) treatment downregulated 30413800 31 Mouse circDYM circRNA chronic unpredictable stress (CUMS) and lipopolysaccharide (LPS) major depressive disorder (MDD) plasma; hippocampus chronic unpredictable stress (CUS) and lipopolysaccharide (LPS) treatment downregulated 30413800 32 Mouse circEhmt1 circRNA hypoxia diabetic retinopathy (DR) endotheliocytes hypoxia treatment We also found that hypoxia upregulated circEhmt1 expression in pericytes 33815662 33 Mouse circELF2 circRNA carbon tetrachloride (CCl4) liver fibrosis hepatic stellate cells (HSCs) carbon tetrachloride (CCl4) treatment downregulated 32308754 34 Mouse circEPRS circRNA carbon tetrachloride (CCl4) liver fibrosis hepatic stellate cells (HSCs) carbon tetrachloride (CCl4) treatment downregulated 32308754 35 Mouse circFBXW4 circRNA carbon tetrachloride (CCl4) liver fibrosis hepatic stellate cells (HSCs) carbon tetrachloride (CCl4) treatment downregulated 32308754 36 Mouse circFBXW4 circRNA carbon tetrachloride (CCl4) liver fibrosis hepatic stellate cells (HSCs) carbon tetrachloride (CCl4) treatment upregulated 32308754 37 Mouse circFoxO3 circRNA glutamate neurodegenerative diseases HT22 cells glutamate treatment Silencing of circFoxO3 Protects HT22 Cells from Glutamate-Induced Oxidative Injury via Regulating the Mitochondrial Apoptosis Pathway 32140899 38 Mouse circHECTD1 circRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral infarction (CI) HT22 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment "Circ_HECTD1 and FSTL1 were highly expressed, and miR-27a-3p was decreased in OGD/R-treated HT22 cells" 33843447 39 Mouse circHECTD1 circRNA oxygen glucose deprivation (OGD) cerebral ischemia/reperfusion (I/R) injury HT22 cells oxygen-glucose deprivation (OGD) treatment "Circ_HECTD1 knockdown inhibited the expression of TRAF3 by targeting miR-133b, thereby attenuating neuronal injury caused by cerebral ischemia" 33148417 40 Mouse circHECTD1 circRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia/reperfusion (I/R) injury HT22 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment "The results showed that the expression of circ-HECTD1 and tumor necrosis factor receptor-associated factor 3 (TRAF3) was remarkably upregulated, while miR-133b was downregulated in oxygen-glucose deprivation (OGD)-induced HT22 cells and mouse middle cerebral artery occlusion (MCAO) model circ-HECTD1 knockdown relieved OGD-caused neuronal cell death in vitro Simultaneously, circ-HECTD1 knockdown improved cerebral infarction volume and neuronal apoptosis in MCAO mice" 33148417 41 Mouse circHECTD1 circRNA silicon dioxide (SiO2) macrophage activation RAW264.7 macrophage cell line silicon dioxide (SiO2) treatment downregulated 29290828 42 Mouse circHECTD1 circRNA silicon dioxide (SiO2) lung fibrosis mouse endothelial cell line (MML1) silicon dioxide (SiO2) treatment SiO 2 concomitantly increased circHECTD1 expression 29540674 43 Mouse circHIPK3 circRNA ovalbumin (OVA) allergic rhinitis (AR) CD4+ Th2 cells ovalbumin induction upregulated 32242002 44 Mouse circHIPK3 circRNA angiotensin II (Ang II) cardiac fibrosis cardiac fibroblasts (CFs) angiotensin II (Ang II) treatment "circ_HIPK3 expression markedly increased in CFs and heart tissues after the treatment of Ang II. Circ_HIPK3 silencing attenuates CFs proliferation, migration and the upregulation of a-SMA expression levels induced by Ang II in vitro" 30967276 45 Mouse circHIPK3 circRNA adrenaline heart failure (HF) Primary NMCMs (neonatal mouse cardiomyocytes) adrenaline treatment upregulated 31595165 46 Mouse circHIPK3 circRNA lipopolysaccharide (LPS) myocardial dysfunction myocardial tissues; H9c2 cells lipopolysaccharide (LPS) treatment circHIPK3 expression is significantly upregulated when exposed to LPS in vivo and in vitro. 33240996 47 Mouse circHIPK3 circRNA H2O2 myocardial infarction (MI) cardiac endothelial cells H2O2 treatment downregulated 32733638 48 Mouse circHIPK3 circRNA ischemia/reperfusion (I/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) mouse cardiomyocytes ischemia/reperfusion (I/R) treatment The expression of circHIPK3 was upregulated during myocardial I/R injury and hypoxia/reoxygenation (H/R) injury of cardiomyocytes. 33824287 49 Mouse circHIPK3 circRNA hypoxia oxidative stress Primary cultures of neonatal mouse cardiomyocytes hypoxia induce upregulated 31885817 50 Mouse circHIPK3 circRNA bleomycin (BLM) lung fibrosis fibroblast bleomycin (BLM) treatment upregulated 30796204 51 Mouse circHomer1 circRNA methamphetamine (METH) neuronal cell injury HT22 cells Methamphetamine (METH) treatment upregulated 32450188 52 Mouse circIns2 circRNA palmitate and glucose ¦Â-cell dysfunction ¦ÂTC6 cells palmitate and glucose treatment upregulated 32560282 53 Mouse circKrt13 circRNA Sheng-ji Hua-yu (SJHY) formula diabetic foot ulcer (DFU) skin tissues Sheng-ji Hua-yu (SJHY) treatment downregulated 33271241 54 Mouse circKrt13 circRNA Sheng-ji Hua-yu (SJHY) formula diabetic foot ulcer (DFU) ulceration surface sheng-ji Hua-yu (SJHY) formula treatment "RNA-seq identified 11 DE circRNAs and 476 DE mRNAs between SJHY formula-treated and diabetic mice, including 4 upregulated and 7 downregulated circRNAs, 311 upregulated and 165 downregulated mRNAs CircRNA-Krt13/miR-665-3p/Itga3 and circRNA-Krt14/miR-706/Mylk4 pathways were built, which may contribute to the healing of SJHY formula-treated diabetic wounds" 33271241 55 Mouse circKrt14 circRNA Sheng-ji Hua-yu (SJHY) formula diabetic foot ulcer (DFU) skin tissues Sheng-ji Hua-yu (SJHY) treatment downregulated 33271241 56 Mouse circKrt14 circRNA sheng-ji Hua-yu (SJHY) formula diabetic foot ulcer (DFU) ulceration surface sheng-ji Hua-yu (SJHY) formula treatment "RNA-seq identified 11 DE circRNAs and 476 DE mRNAs between SJHY formula-treated and diabetic mice, including 4 upregulated and 7 downregulated circRNAs, 311 upregulated and 165 downregulated mRNAs CircRNA-Krt13/miR-665-3p/Itga3 and circRNA-Krt14/miR-706/Mylk4 pathways were built, which may contribute to the healing of SJHY formula-treated diabetic wounds" 33271241 57 Mouse circLRP6 circRNA high glucose (HG) diabetic nephropathy (DN) The mouse mesangial SV40©\Mes13 cells "SV40©\Mes13 cells were cultured under normal glucose condition (Con, 5.5 mM glucose), mannitol condition (MN, 5.5 mM glucose + 24.5 mM mannitol), or HG condition (30 mM glucose) for 24 hr. treatment" "circLRP6 regulates HG©\induced proliferation, oxidative stress, ECM accumulation, and inflammation in mesangial cells via sponging miR©\205" 31087368 58 Mouse circMapk1 circRNA bisphenol A (BPA) apoptosis ?GC-2 cells bisphenol A (BPA) treatment upregulated 31020848 59 Mouse circMpp6 circRNA bisphenol A (BPA) apoptosis ?GC-2 cells bisphenol A (BPA) treatment upregulated 31020848 60 Mouse circNFIB circRNA TGF-¦Â cardiac fibrosis primary adult cardiac fibroblasts TGF-¦Â treatment "The expression of circRNA-circNFIB was decreased in mice post-myocardial infarction heart samples, as well as in primary adult cardiac fibroblasts treated with TGF-¦Â Overexpression of circNFIB attenuates cardiac fibroblast proliferation induced by TGF-¦Â" 31316543 61 Mouse circPAN3 circRNA ischemia/reperfusion (I/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) mouse cardiomyocytes ischemia/reperfusion (I/R) treatment "?In this study, we found that the expression of circPAN3 (circular RNA PAN3) was decreased in a mouse model of myocardial I/R." 33483599 62 Mouse circPostn circRNA hypoxia/reoxygenation (H/R) myocardial infarction (MI) mouse cardiomyocytes hypoxia and reoxygenation (H/R) treatment "We identified that the expression of circPostn was elevated in the plasma of MI patients, MI mouse model, and hypoxia and reoxygenation (H/R)-treated human cardiomyocytes." 33681183 63 Mouse circPPM1F circRNA lipopolysaccharide (LPS) pancreatic islet injury M1 macrophage Lipopolysaccharide (LPS) treatment circPPM1F is a novel positive regulator of M1 macrophage activation through the circPPM1F-HuR-PPM1F-NF-¦ÊB axis. 33042261 64 Mouse circPSD3 circRNA carbon tetrachloride (CCl4) liver fibrosis hepatic stellate cells (HSCs) carbon tetrachloride (CCl4) treatment "For instance, the expression of circPSD3, a circRNA derived from the Pleckstrin and Sec7 domain-containing 3 (PSD3) gene, was considerably downregulated in primary hepatic stellate cells (HSCs) and liver tissues of mice with CCl4-induced HF compared to those in the vehicle group." 33614234 65 Mouse circPtchd2 circRNA prenatal alcohol exposure (PAE) fetal alcohol spectrum disorders (FASD) brain prenatal alcohol exposure (PAE) treatment upregulated 33304235 66 Mouse circRar1 circRNA lead (Pb) lead (Pb) toxicity mouse neuroblastoma N2a cells PbAc treatment upregulated 27604105 67 Mouse circRasGEF1B circRNA lipopolysaccharide (LPS) inflammation RAW264.7 cells lipopolysaccharide (LPS) treatment upregulated 28947785 68 Mouse circRIC3 circRNA melatonin calcific aortic valve disease (CAVD) valvular interstitial cells melatonin treatment melatonin ameliorates aortic valve calcification via the regulation of CircRIC3/miR-204-5p/DPP4 signaling in hVICs 32369647 69 Mouse circRIMS2 circRNA aerobic exercise vascular cognitive impairment (VCI) HT22 cells aerobic exercise training (AET) treatment "Aerobic exercise could shorten the average time that mice reached the platform in the Morris water maze, increase the expression level of circRIMS2 and BDNF, reduce miR-186 expression, and inhibit neuronal apoptosis." 33413076 70 Mouse circRPRD1b circRNA carbon tetrachloride (CCl4) liver fibrosis hepatic stellate cells (HSCs) carbon tetrachloride (CCl4) treatment downregulated 32308754 71 Mouse circRtn4 circRNA tumor necrosis factor alpha (TNF-¦Á) osteoporosis MC3T3-E1 cells tumor necrosis factor alpha (TNF-¦Á) treatment Rtn4-Exos attenuated TNF-¦Á-induced cytotoxicity and apoptosis in murine MC3T3-E1 cells by sponging miR-146a 32400849 72 Mouse circS-7 circRNA hypoxia myocardial infarction (MI) cardiomyocytes hypoxia treatment upregulated 26998750 73 Mouse circSAMD4A circRNA high fat diet (HFD) obesity preadipocyte high fat diet (HFD) feed "CircSAMD4A regulated preadipocyte differentiation by acting as a miR-138-5p sponge, and thus increasing EZH2 expression." 32292524 74 Mouse circSHOC2 circRNA oxygen glucose deprivation (OGD) ischemic stroke (IS) primary astrocytes oxygen glucose deprivation (OGD) treatment circSHOC2 in IPAS-EXOs suppressed neuronal apoptosis and ameliorated neuronal damage by regulating autophagy and acting on the miR-7670-3p/SIRT1 axis 33230464 75 Mouse circSOS1 circRNA carbon tetrachloride (CCl4) liver fibrosis hepatic stellate cells (HSCs) carbon tetrachloride (CCl4) treatment downregulated 32308754 76 Mouse circTADA2A circRNA bleomycin (BLM) idiopathic pulmonary fibrosis (IPF) lung tissues bleomycin (BLM) treatment circTADA2A repressed lung-fibroblasts activation via miR-526b/Cav1 and reduced lung-fibroblasts proliferation via miR-203/Cav2. 32694556 77 Mouse circTbc1d20 circRNA bisphenol A (BPA) apoptosis ?GC-2 cells bisphenol A (BPA) treatment upregulated 31020848 78 Mouse circTns3 circRNA tanshinone IIA (Tan IIA) atherosclerosis (AS) RAW 264.7 cells Tanshinone IIA (Tan) treatment downregulated 32337768 79 Mouse circUBE2K circRNA carbon tetrachloride (CCl4) liver fibrosis hepatic stellate cells (HSCs) carbon tetrachloride (CCl4) treatment upregulated 32308754 80 Mouse circUCK2 circRNA oxygen glucose deprivation (OGD) ischemic stroke (IS) HT-22 cells oxygen-and-glucose-deprivation (OGD) treatment Overexpression of circRNA circUCK2 Attenuates Cell Apoptosis in Cerebral Ischemia-Reperfusion Injury via miR-125b-5p/GDF11 Signaling 33230465 81 Mouse circWBSCR17 circRNA streptozocin (STZ) diabetic nephropathy (DN) kidney cortex tissues streptozotocin (STZ) treatment upregulated 32798559 82 Mouse circWdr91 circRNA tanshinone IIA (Tan IIA) atherosclerosis (AS) RAW 264.7 cells Tanshinone IIA (Tan) treatment downregulated 32337768 83 Mouse circWwp1 circRNA isoproterenol hydrochloride cardiac hypertrophy left ventricular specimens isoproterenol hydrochloride treatment downregulated 32023551 84 Mouse circZC3H4 circRNA silicon dioxide (SiO2) lung fibrosis RAW264.7 cells silicon dioxide (SiO2) treatment upregulated 29401612 85 Mouse circZNF609 circRNA adriamycin (ADR) focal segmental glomerulosclerosis (FSGS) kidney tissues adriamycin (ADR) treatment upregulated 32800553 86 Mouse mmu_circ_0000038 circRNA Japanese encephalitis virus (JEV) Japanese encephalitis virus (JEV) infection brain tissues; BV2 cells Japanese encephalitis virus (JEV) infection upregulated 32552669 87 Mouse mmu_circ_0000120 circRNA TGF-¦Â1 cardiac fibrosis cardiac fibroblasts TGF-¦Â1 treatment upregulated 32062386 88 Mouse mmu_circ_0000220 circRNA Japanese encephalitis virus (JEV) Japanese encephalitis virus (JEV) infection brain tissues; BV2 cells Japanese encephalitis virus (JEV) infection upregulated 32552669 89 Mouse mmu_circ_0000372 circRNA high glucose (HG) diabetic nephropathy (DN) Mouse primary kidney GEC (C57-6014G) and mouse glomerular mesangial cells (GMC) (SV40 MES 13) and derived exosomes high glucose (HG) treatment downregulated 31497190 90 Mouse mmu_circ_0000455 circRNA house dust mite (HDM) allergic asthma (AA) lung tissues house dust mite allergen treatment upregulated 33173985 91 Mouse mmu_circ_0000468 circRNA "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)" parkinson's disease (PD) Parkinson's disease (PD) group "1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) treatment" downregulated 32344560 92 Mouse mmu_circ_0000491 circRNA high glucose (HG) diabetic nephropathy (DN) mouse mesangial cells (MES13 cells) high glucose (HG) treatment circ_0000491 aggravates the extracellular matrix of diabetic nephropathy glomerular mesangial cells through suppressing miR-101b by targeting TGF¦ÂRI. 32901868 93 Mouse mmu_circ_0000505 circRNA high glucose (HG) diabetic nephropathy (DN) Mouse primary kidney GEC (C57-6014G) and mouse glomerular mesangial cells (GMC) (SV40 MES 13) and derived exosomes high glucose (HG) treatment downregulated 31497190 94 Mouse mmu_circ_0000512 circRNA TGF-¦Â1 cardiac fibrosis cardiac fibroblasts TGF-¦Â2 treatment upregulated 32062386 95 Mouse mmu_circ_0000517 circRNA "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)" parkinson's disease (PD) striatum (ST) "1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) treatment" upregulated 32344560 96 Mouse mmu_circ_0000623 circRNA carbon tetrachloride (CCl4) liver fibrosis hepatic tissue carbon tetrachloride (CCl4) treatment mmu_circ_0000623 expression was downregulated in CCl4-induced mice. 32633558 97 Mouse mmu_circ_0000629 circRNA house dust mite (HDM) allergic asthma (AA) lung tissues house dust mite allergen treatment upregulated 33173985 98 Mouse mmu_circ_0000668 circRNA oxygen retinopathy of prematurity (ROP) retinas tissue "For OIR model construction, 7-day-old mice and their nursing mothers were maintained in 75% oxygen for 5 continuous days. On postnatal day (P) 12, the pups were returned to normoxic air and kept with their mothers for another 5 days. treatment" predicted to be ceRNAs that regulate angiogenesis-associated coding genes in ROP by competing with miR-203-3p 31452702 99 Mouse mmu_circ_0000723 circRNA house dust mite (HDM) allergic asthma (AA) lung tissues house dust mite allergen treatment downregulated 33173985 100 Mouse mmu_circ_0000790 circRNA hypoxia hypoxic pulmonary hypertension (HPH) pulmonary artery smooth muscle cells (PASMCs) hypoxic treatment mmu_circ_0000790 Is Involved in Pulmonary Vascular Remodeling in Mice with HPH via MicroRNA-374c-Mediated FOXC1. 32199127 101 Mouse mmu_circ_0000870 circRNA "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)" parkinson's disease (PD) striatum (ST) "1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) treatment" downregulated 32344560 102 Mouse mmu_circ_0000981 circRNA atractylon (Atr) asthma asthma mouse lung tissues; TGF-¦Â1-treated TC-1 cells atractylon (Atr)?treatment Atr treatment suppressed OVA-induced circRNA-0000981 and TGFBR2 expression but promoted miR-211-5p expression. 33855682 103 Mouse mmu_circ_0000981 circRNA ovalbumin (OVA) asthma lung tissues ovalbumin (OVA) treatment upregulated 33855682 104 Mouse mmu_circ_0000981 circRNA TGF-¦Â1 asthma TC-1 cells TGF-¦Â1 treatment upregulated 33855682 105 Mouse mmu_circ_0001066 circRNA bisphosphonates (BPs) osteoclastogenesis RAW264.7 cells bisphosphonates (BPs) treatment Four MRONJ-related miRNAs were upregulated in BP-treated RAW264.7 cells and the expression of mmu_circ_0001066 was negatively correlated with those of MRONJ-related miRNAs. 33837656 106 Mouse mmu_circ_0001204 circRNA TGF-¦Â1 cardiac fibrosis cardiac fibroblasts TGF-¦Â3 treatment upregulated 32062386 107 Mouse mmu_circ_0001223 circRNA panax notoginseng saponins (SLPN) depression mouse ventral medial prefrontal cortex (VMPC) panax notoginseng saponins (SLPN) treatment "mmu_circ_0001223 expression was greatly decreased in CUMS mice, but significantly elevated by SLPN treatment" 30298999 108 Mouse mmu_circ_0001320 circRNA "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)" parkinson's disease (PD) Parkinson's disease (PD) group "1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) treatment" upregulated 32344560 109 Mouse mmu_circ_0001336 circRNA ischemia/reperfusion (I/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) cardiac extracellular vesicles (EVs) ischemia/reperfusion (I/R) treatment dysregulated 31466885 110 Mouse mmu_circ_0001359 circRNA ovalbumin (OVA) asthma lung tissues ovalbumin (OVA) treatment upregulated 32018116 111 Mouse mmu_circ_0001454 circRNA house dust mite (HDM) allergic asthma (AA) lung tissues house dust mite allergen treatment downregulated 33173985 112 Mouse mmu_circ_0001520 circRNA concanamycin A (Con A) autoimmune hepatitis (AIH) liver tissues concanavalin A (Con A) treatment upregulated 32965791 113 Mouse mmu_circ_0001605 circRNA high glucose (HG) diabetic nephropathy (DN) Mouse primary kidney GEC (C57-6014G) and mouse glomerular mesangial cells (GMC) (SV40 MES 13) and derived exosomes high glucose (HG) treatment downregulated 31497190 114 Mouse mmu_circ_0001632 circRNA TGF-¦Â1 cardiac fibrosis cardiac fibroblasts TGF-¦Â6 treatment downregulated 32062386 115 Mouse mmu_circ_0001645 circRNA TGF-¦Â1 cardiac fibrosis cardiac fibroblasts TGF-¦Â4 treatment downregulated 32062386 116 Mouse mmu_circ_000203 circRNA angiotensin II (Ang II) cardiac fibrosis mouse cardiac fibroblasts angiotensin II (Ang II) treatment upregulated 28079129 117 Mouse mmu_circ_000203 circRNA angiotensin II (Ang II) cardiac hypertrophy neonatal mouse ventricular cardiomyocytes (NMVCs) angiotensin II (Ang II) treatment CircRNA_000203 was found to be upregulated in the myocardium of Ang-II-infused mice and in the cytoplasma of Ang-II-treated neonatal mouse ventricular cardiomyocytes (NMVCs). 31397837 118 Mouse mmu_circ_0003292 circRNA "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)" parkinson's disease (PD) striatum (ST) "1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) treatment" downregulated 32344560 119 Mouse mmu_circ_0003865 circRNA melatonin osteoporosis human bone marrow mesenchymal stem cell (hBMSC) melatonin (MEL) treatment Circ_0003865 expression in BMSCs was significantly decreased by MEL treatment. 33632317 120 Mouse mmu_circ_0004144 circRNA "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)" parkinson's disease (PD) Parkinson's disease (PD) group "1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) treatment" downregulated 32344560 121 Mouse mmu_circ_0004158 circRNA oxygen retinopathy of prematurity (ROP) retinas tissue "For OIR model construction, 7-day-old mice and their nursing mothers were maintained in 75% oxygen for 5 continuous days. On postnatal day (P) 12, the pups were returned to normoxic air and kept with their mothers for another 5 days. treatment" predicted to be ceRNAs that regulate angiogenesis-associated coding genes in ROP by competing with let-7k 31452702 122 Mouse mmu_circ_0004646 circRNA ischemia/reperfusion (I/R) acute kidney injury (AKI) kidney tissues ischemia/reperfusion (I/R) treatment dysregulated 29245971 123 Mouse mmu_circ_0005324 circRNA oxygen retinopathy of prematurity (ROP) retinas tissue "For OIR model construction, 7-day-old mice and their nursing mothers were maintained in 75% oxygen for 5 continuous days. On postnatal day (P) 12, the pups were returned to normoxic air and kept with their mothers for another 5 days. treatment" predicted to be ceRNAs that regulate angiogenesis-associated coding genes in ROP by competing with let-7k 31452702 124 Mouse mmu_circ_0005477 circRNA oxygen retinopathy of prematurity (ROP) retinas tissue "For OIR model construction, 7-day-old mice and their nursing mothers were maintained in 75% oxygen for 5 continuous days. On postnatal day (P) 12, the pups were returned to normoxic air and kept with their mothers for another 5 days. treatment" predicted to be ceRNAs that regulate angiogenesis-associated coding genes in ROP by competing with miR-203-3p and miR-5128 31452702 125 Mouse mmu_circ_0005768 circRNA oxygen retinopathy of prematurity (ROP) retinas tissue "For OIR model construction, 7-day-old mice and their nursing mothers were maintained in 75% oxygen for 5 continuous days. On postnatal day (P) 12, the pups were returned to normoxic air and kept with their mothers for another 5 days. treatment" predicted to be ceRNAs that regulate angiogenesis-associated coding genes in ROP by competing with let-7k 31452702 126 Mouse mmu_circ_0007799 circRNA oxygen retinopathy of prematurity (ROP) retinas tissue "For OIR model construction, 7-day-old mice and their nursing mothers were maintained in 75% oxygen for 5 continuous days. On postnatal day (P) 12, the pups were returned to normoxic air and kept with their mothers for another 5 days. treatment" predicted to be ceRNAs that regulate angiogenesis-associated coding genes in ROP by competing with miR-5128 31452702 127 Mouse mmu_circ_0008737 circRNA oxygen retinopathy of prematurity (ROP) retinas tissue "For OIR model construction, 7-day-old mice and their nursing mothers were maintained in 75% oxygen for 5 continuous days. On postnatal day (P) 12, the pups were returned to normoxic air and kept with their mothers for another 5 days. treatment" predicted to be ceRNAs that regulate angiogenesis-associated coding genes in ROP by competing with let-7k 31452702 128 Mouse mmu_circ_001007 circRNA ischemia/reperfusion (I/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) cardiac extracellular vesicles (EVs) ischemia/reperfusion (I/R) treatment dysregulated 31466885 129 Mouse mmu_circ_0012530 circRNA TGF-¦Â1 cardiac fibrosis cardiac fibroblasts TGF-¦Â5 treatment downregulated 32062386 130 Mouse mmu_circ_001265 circRNA "3,4-benzopyrene/angiotensin II" abdominal aortic aneurysm (AAA) abdominal aortic tissues "3,4-benzopyrene/angiotensin II induce" downregulated 30614051 131 Mouse mmu_circ_0012698 circRNA oxygen retinopathy of prematurity (ROP) retinas tissue "For OIR model construction, 7-day-old mice and their nursing mothers were maintained in 75% oxygen for 5 continuous days. On postnatal day (P) 12, the pups were returned to normoxic air and kept with their mothers for another 5 days. treatment" predicted to be ceRNAs that regulate angiogenesis-associated coding genes in ROP by competing with miR-203-3p 31452702 132 Mouse mmu_circ_0013321 circRNA "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)" parkinson's disease (PD) Parkinson's disease (PD) group "1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) treatment" downregulated 32344560 133 Mouse mmu_circ_0013414 circRNA oxygen retinopathy of prematurity (ROP) retinas tissue "For OIR model construction, 7-day-old mice and their nursing mothers were maintained in 75% oxygen for 5 continuous days. On postnatal day (P) 12, the pups were returned to normoxic air and kept with their mothers for another 5 days. treatment" predicted to be ceRNAs that regulate angiogenesis-associated coding genes in ROP by competing with miR-203-3p 31452702 134 Mouse mmu_circ_001489 circRNA "IFN-¦Ã, lipopolysaccharide (LPS) and IL-4" macrophage differentiation and polarization bone marrow-derived macrophages (BMDMs) "M1 macrophages induced by interferon-¦Ã and LPS , M2 macrophages induced by interleukin-4" differentlly regulated in M1 compared to M2 28075448 135 Mouse mmu_circ_001741 circRNA electroacupuncture (EA) morphine addiction nucleus accumbens (NAc) electroacupuncture (EA) treatment upregulated 31240833 136 Mouse mmu_circ_0019157 circRNA Japanese encephalitis virus (JEV) Japanese encephalitis virus (JEV) infection brain tissues; BV2 cells Japanese encephalitis virus (JEV) infection upregulated 32552669 137 Mouse mmu_circ_0020896 circRNA Japanese encephalitis virus (JEV) Japanese encephalitis virus (JEV) infection brain tissues; BV2 cells Japanese encephalitis virus (JEV) infection downregulated 32552669 138 Mouse mmu_circ_002581 circRNA high concentration of free fatty acids nonalcoholic steatohepatitis (NASH) NCTC-1469 cells high concentration of free fatty acids treatment circRNA_002581 was upregulated in HFFA-induced NASH cell-like model. 32054840 139 Mouse mmu_circ_002813 circRNA "3,4-benzopyrene/angiotensin II" abdominal aortic aneurysm (AAA) abdominal aortic tissues "3,4-benzopyrene/angiotensin II induce" downregulated 30614051 140 Mouse mmu_circ_002856 circRNA "3,4-benzopyrene/angiotensin II" abdominal aortic aneurysm (AAA) abdominal aortic tissues "3,4-benzopyrene/angiotensin II induce" upregulated 30614051 141 Mouse mmu_circ_0029726 circRNA Japanese encephalitis virus (JEV) Japanese encephalitis virus (JEV) infection brain tissues; BV2 cells Japanese encephalitis virus (JEV) infection downregulated 32552669 142 Mouse mmu_circ_0032636 circRNA Japanese encephalitis virus (JEV) Japanese encephalitis virus (JEV) infection brain tissues; BV2 cells Japanese encephalitis virus (JEV) infection downregulated 32552669 143 Mouse mmu_circ_003410 circRNA electroacupuncture (EA) morphine addiction nucleus accumbens (NAc) electroacupuncture (EA) treatment downregulated 31240833 144 Mouse mmu_circ_003424 circRNA "IFN-¦Ã, lipopolysaccharide (LPS) and IL-4" macrophage differentiation and polarization bone marrow-derived macrophages (BMDMs) "M1 macrophages induced by interferon-¦Ã and LPS , M2 macrophages induced by interleukin-4" differentlly regulated in M1 compared to M2 28075448 145 Mouse mmu_circ_0037128 circRNA high glucose (HG) diabetic nephropathy (DN) mesangial cells (MCs) high glucose (HG) treatment It was found that expression of circ_0037128 was significantly increased in mouse DN model and high glucose treated mesangial cells (MCs) 32860899 146 Mouse mmu_circ_003780 circRNA "IFN-¦Ã, lipopolysaccharide (LPS) and IL-4" macrophage differentiation and polarization bone marrow-derived macrophages (BMDMs) "M1 macrophages induced by interferon-¦Ã and LPS , M2 macrophages induced by interleukin-4" differentlly regulated in M1 compared to M2 28075448 147 Mouse mmu_circ_0044226 circRNA bleomycin (BLM) idiopathic pulmonary fibrosis (IPF) lung lobes bleomycin (BLM) treatment upregulated 31786325 148 Mouse mmu_circ_004742 circRNA "3,4-benzopyrene/angiotensin II" abdominal aortic aneurysm (AAA) abdominal aortic tissues "3,4-benzopyrene/angiotensin II induce" upregulated 30614051 149 Mouse mmu_circ_0047814 circRNA streptozocin (STZ) diabetic retinopathy (DR) retinal vessels streptozotocin (STZ) treatment upregulated 32343678 150 Mouse mmu_circ_005186 circRNA ischemia/reperfusion (I/R) liver damage mouse liver tissues ischemia/reperfusion (I/R) treatment mmu-circ_005186 dysregulated 30670716 151 Mouse mmu_circ_0054633 circRNA lipopolysaccharide (LPS) acute lung injury (ALI) murine pulmonary microvascular endothelial cells (MPVECs) lipopolysaccharide (LPS) treatment Quietness of circ_0054633 alleviated LPS-induced ALI via NF-¦ÊB signaling pathway. 32950633 152 Mouse mmu_circ_0054633 circRNA lipopolysaccharide (LPS) acute lung injury (ALI) Primary murine pulmonary microvascular endothelial cells (MPVECs) lipopolysaccharide (LPS) treatment upregulated 32950633 153 Mouse mmu_circ_0061052 circRNA cigarette smoke (CS) epithelial-mesenchymal transition (EMT) lung tissues Cigarette smoke (CS) exposure upregulated 32768781 154 Mouse mmu_circ_006636 circRNA hypoxia autophagy primary mouse cardiomyocytes culture hypoxia induce circRNA_006636 inhibits autophagy and cell death in cardiomyocytes 30349076 155 Mouse mmu_circ_007845 circRNA ischemia/reperfusion (I/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) cardiac extracellular vesicles (EVs) ischemia/reperfusion (I/R) treatment dysregulated 31466885 156 Mouse mmu_circ_007893 circRNA calcitonin gene-related peptide (CGRP) inflammation RAW264.7 macrophages calcitonin gene-related peptide (CGRP) treatment upregulated 29039515 157 Mouse mmu_circ_0080425 circRNA high glucose (HG) diabetic nephropathy (DN) Mouse mesangial cells (MCs) high glucose treatment upregulated 31680239 158 Mouse mmu_circ_0080425 circRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissues streptozotocin treatment upregulated 31680239 159 Mouse mmu_circ_008228 circRNA ischemia/reperfusion (I/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) cardiac extracellular vesicles (EVs) ischemia/reperfusion (I/R) treatment dysregulated 31466885 160 Mouse mmu_circ_008351 circRNA ischemia/reperfusion (I/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) cardiac extracellular vesicles (EVs) ischemia/reperfusion (I/R) treatment dysregulated 31466885 161 Mouse mmu_circ_009056 circRNA calcitonin gene-related peptide (CGRP) osteogenesis MC3T3 cells calcitonin gene-related peptide (CGRP) treatment "The expression of mmu_circ_009056 was upregulated in the CGRP-induced cells, whereas miR-22-3p was obviously decreased." 29709471 162 Mouse mmu_circ_009537 circRNA "3,4-benzopyrene/angiotensin II" abdominal aortic aneurysm (AAA) abdominal aortic tissues "3,4-benzopyrene/angiotensin II induce" upregulated 30614051 163 Mouse mmu_circ_009839 circRNA "3,4-benzopyrene/angiotensin II" abdominal aortic aneurysm (AAA) abdominal aortic tissues "3,4-benzopyrene/angiotensin II induce" upregulated 30614051 164 Mouse mmu_circ_010056 circRNA "IFN-¦Ã, lipopolysaccharide (LPS) and IL-4" macrophage differentiation and polarization bone marrow-derived macrophages (BMDMs) "M1 macrophages induced by interferon-¦Ã and LPS , M2 macrophages induced by interleukin-4" differentlly regulated in M1 compared to M2 28075448 165 Mouse mmu_circ_010231 circRNA "IFN-¦Ã, lipopolysaccharide (LPS) and IL-4" macrophage differentiation and polarization bone marrow-derived macrophages (BMDMs) "M1 macrophages induced by interferon-¦Ã and LPS , M2 macrophages induced by interleukin-4" differentlly regulated in M1 compared to M2 28075448 166 Mouse mmu_circ_010383 circRNA high glucose (HG) diabetic nephropathy (DN) mouse mesangial cells; mouse tubular epithelial cells high glucose (HG) treatment circRNA_010383 expression was markedly downregulated in tubular epithelial cells cultured in high-glucose conditions. 33203695 167 Mouse mmu_circ_010383 circRNA high glucose (HG) diabetic nephropathy (DN) kidney tissues high glucose (HG) treatment "We found that circRNA_010383 expression was markedly downregulated in diabetic kidneys, mesangial cells, and tubular epithelial cells cultured in high-glucose conditions." 33472945 168 Mouse mmu_circ_010567 circRNA angiotensin II (Ang II) cardiac fibrosis diabetic mice diabetic mice myocardium angiotensin II (Ang II) treatment upregulated 28412345 169 Mouse mmu_circ_012091 circRNA SiO2 silicosis L929 cells SiO2 treatment downregulated 30908929 170 Mouse mmu_circ_013120 circRNA ischemia brain injury after stroke brain tissues treat with focal cerebral ischemia dysregulated 29156814 171 Mouse mmu_circ_013630 circRNA "IFN-¦Ã, lipopolysaccharide (LPS) and IL-4" macrophage differentiation and polarization bone marrow-derived macrophages (BMDMs) "M1 macrophages induced by interferon-¦Ã and LPS , M2 macrophages induced by interleukin-4" differentlly regulated in M1 compared to M2 28075448 172 Mouse mmu_circ_013683 circRNA "3,4-benzopyrene/angiotensin II" abdominal aortic aneurysm (AAA) abdominal aortic tissues "3,4-benzopyrene/angiotensin II induce" downregulated 30614051 173 Mouse mmu_circ_014015 circRNA glyphosate neurodevelopmental disorder hippocampus tissues glyphosate treatment upregulated 29705695 174 Mouse mmu_circ_014193 circRNA "3,4-benzopyrene/angiotensin II" abdominal aortic aneurysm (AAA) abdominal aortic tissues "3,4-benzopyrene/angiotensin II induce" upregulated 30614051 175 Mouse mmu_circ_015947 circRNA oxygen-glucose deprivation and reoxygenation (OGD/R) neuronal cell injury hippocampal HT22 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 26845359 176 Mouse mmu_circ_016719 circRNA oxygen-glucose deprivation and reoxygenation (OGD/R) stroke HT22 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 31698040 177 Mouse mmu_circ_016901 circRNA ionizing radiation (IR) cell damage mouse bone mesenchymal stem cells (BMSCs) irradiation treatment Irradiation treatment upregulated the expression of circ-016901 and HIPK2 and downregulated miR-1249-5p expression. 33732328 178 Mouse mmu_circ_016901 circRNA X-rays radiation-induced injury bone marrow stem cells X-ray treatment "mmu-circRNA_016901 affects the expression of TGF-¦Â3 through miRNA1249-5p, and thus participates in the regulation of the radiation damage mechanism of bone marrow mesenchymal stem cells" 32552977 179 Mouse mmu_circ_018127 circRNA "IFN-¦Ã, lipopolysaccharide (LPS) and IL-4" macrophage differentiation and polarization bone marrow-derived macrophages (BMDMs) "M1 macrophages induced by interferon-¦Ã and LPS , M2 macrophages induced by interleukin-4" differentlly regulated in M1 compared to M2 28075448 180 Mouse mmu_circ_018331 circRNA "3,4-benzopyrene/angiotensin II" abdominal aortic aneurysm (AAA) abdominal aortic tissues "3,4-benzopyrene/angiotensin II induce" downregulated 30614051 181 Mouse mmu_circ_018725 circRNA alcohol alcoholic hepatitis (AH) Liver tissues "The mice in the model group were fed with EtOH (5% v/v) liquid diet ad 88 libitum for 10 days, culminating with single dose binge alcohol administration (5 g/kg, body weight, 20% EtOH). All mice were killed 9 h after EtOH gavage." circ_018725 was upregulated in the EtOH-fed mice. 31493407 182 Mouse mmu_circ_020563 circRNA electroacupuncture (EA) morphine addiction nucleus accumbens (NAc) electroacupuncture (EA) treatment upregulated 31240833 183 Mouse mmu_circ_040736 circRNA electroacupuncture (EA) morphine addiction nucleus accumbens (NAc) electroacupuncture (EA) treatment upregulated 31240833 184 Mouse mmu_circ_046163 circRNA electroacupuncture (EA) morphine addiction nucleus accumbens (NAc) electroacupuncture (EA) treatment upregulated 31240833 185 Mouse mmu_circ_085226 circRNA electroacupuncture (EA) morphine addiction nucleus accumbens (NAc) electroacupuncture (EA) treatment downregulated 31240833 186 Mouse mmu_circ_086093 circRNA electroacupuncture (EA) morphine addiction nucleus accumbens (NAc) electroacupuncture (EA) treatment downregulated 31240833 187 Mouse mmu_circ_09505 circRNA bovine type II collagen rheumatoid arthritis (RA) synovial macrophages bovine type II collagen induction circRNA_09505 can function as a miR-6089 sponge and regulate inflammation via miR-6089/AKT1/NF-¦ÊB axis in collagen-induced arthritis (CIA) mice mice. 33028811 188 Mouse mmu_circ_095551 circRNA electroacupuncture (EA) morphine addiction nucleus accumbens (NAc) electroacupuncture (EA) treatment downregulated 31240833 189 Mouse mmu_circ_10042 circRNA bone morphogenetic protein 2 (BMP2) osteogenesis Murine MC3T3-E1 osteoblastic cells bone morphogenetic protein 2 (BMP2) treatment upregulated 28395271 190 Mouse mmu_circ_101237 circRNA anoxia/reoxygenation (A/R) cardiovascular disease (CVD) primary cardiomyocytes anoxia/reoxygenation (A/R) treatment upregulated 31894303 191 Mouse mmu_circ_101237 circRNA anoxia/reoxygenation (A/R) myocardial infarction (MI) Primary cardiomyocyte anoxia/reoxygenation (A/R) treatment circRNA_101237 was induced by A/R injury in a time-dependent manner and that circRNA_101237 knockdown protected cardiomyocytes from A/R-mediated apoptosis. 31894303 192 Mouse mmu_circ_1045 circRNA deoxycorticosterone acetate-salt hypertension hypertensive nephropathy (HN) kidney tissues deoxycorticosterone acetate-salt hypertension treatment upregulated 31782248 193 Mouse mmu_circ_1202 circRNA deoxycorticosterone acetate-salt hypertension hypertensive nephropathy (HN) kidney tissues deoxycorticosterone acetate-salt hypertension treatment upregulated 31782248 194 Mouse mmu_circ_1350 circRNA deoxycorticosterone acetate-salt hypertension hypertensive nephropathy (HN) kidney tissues deoxycorticosterone acetate-salt hypertension treatment downregulated 31782248 195 Mouse mmu_circ_1387 circRNA deoxycorticosterone acetate-salt hypertension hypertensive nephropathy (HN) kidney tissues deoxycorticosterone acetate-salt hypertension treatment upregulated 31782248 196 Mouse mmu_circ_1528 circRNA deoxycorticosterone acetate-salt hypertension hypertensive nephropathy (HN) kidney tissues deoxycorticosterone acetate-salt hypertension treatment upregulated 31782248 197 Mouse mmu_circ_1639 circRNA ethanol (EtOH) alcoholic liver disease (ALD) Kupffer cells from the livers and RAW 264.7 cells ethanol treatment upregulated 31325635 198 Mouse mmu_circ_1806 circRNA deoxycorticosterone acetate-salt hypertension hypertensive nephropathy (HN) kidney tissues deoxycorticosterone acetate-salt hypertension treatment downregulated 31782248 199 Mouse mmu_circ_19142 circRNA bone morphogenetic protein 2 (BMP2) osteogenesis Murine MC3T3-E1 osteoblastic cells bone morphogenetic protein 2 (BMP2) treatment upregulated 28395271 200 Mouse mmu_circ_1983 circRNA dicalcium silicate microparticle (C2S) bone and dental tissue regenerative applications mesenchymal stem cells (MSCs) dicalcium silicate microparticle (C2S) treatment "C2S-treatment upregulated the expression of circ_1983, Gas7, and Runx2 in BMSCs." 32463418 201 Mouse mmu_circ_2443 circRNA IL-1¦Â osteoarthritis (OA) mouse articular chondrocytes (MACs) IL-1¦Â treatment upregulated 29247798 202 Mouse mmu_circ_2483 circRNA IL-1¦Â osteoarthritis (OA) mouse articular chondrocytes (MACs) IL-1¦Â treatment downregulated 29247798 203 Mouse mmu_circ_28128 circRNA glyphosate neurodevelopmental disorder hippocampus tissues glyphosate treatment upregulated 29705695 204 Mouse mmu_circ_28313 circRNA receptor activator of nuclear factor-¦ÊB ligand (RANKL) and macrophage colony-stimulating factor (CSF1) ovariectomized (OVX)-induced bone resorption bone marrow monocyte/macrophage (BMM) cells receptor activator of nuclear factor-¦ÊB ligand (RANKL) and macrophage colony-stimulating factor (CSF1) treatment "circRNA_28313 was significantly induced by RANKL + CSF1 treatment circRNA_28313 knockdown significantly inhibited RANKL + CSF1-induced differentiation of osteoclasts within BMM cells?in vitro, while suppressed ovariectomized (OVX)-induced bone resorption in mice?in vivo" 31204558 205 Mouse mmu_circ_294 circRNA deoxycorticosterone acetate-salt hypertension hypertensive nephropathy (HN) kidney tissues deoxycorticosterone acetate-salt hypertension treatment downregulated 31782248 206 Mouse mmu_circ_29837 circRNA glyphosate neurodevelopmental disorder hippocampus tissues glyphosate treatment downregulated 29705695 207 Mouse mmu_circ_30365 circRNA IL-1¦Â osteoarthritis (OA) mouse articular chondrocytes (MACs) IL-1¦Â treatment downregulated 29247798 208 Mouse mmu_circ_30365 circRNA IL-1¦Â osteoarthritis (OA) mouse articular chondrocytes (MACs) IL-1¦Â treatment dysregulated 29247798 209 Mouse mmu_circ_30981 circRNA carbon tetrachloride (CCl4) liver fibrosis liver tissues carbon tetrachloride (CCl4) treatment downregulated 30118889 210 Mouse mmu_circ_33186 circRNA IL-1¦Â osteoarthritis (OA) mouse articular chondrocytes (MACs) IL-1¦Â treatment upregulated 29247798 211 Mouse mmu_circ_33186 circRNA IL-1¦Â osteoarthritis (OA) primary cultured chondrocytes IL-1¦Â treatment circRNA.33186 was significantly upregulated in IL-1¦Â-treated chondrocytes and in cartilage tissues of a destabilized medial meniscus (DMM)-induced OA mouse model 30692016 212 Mouse mmu_circ_33594 circRNA carbon tetrachloride (CCl4) liver fibrosis liver tissues carbon tetrachloride (CCl4) treatment upregulated 30118889 213 Mouse mmu_circ_33594 circRNA TGF-¦Â1 liver fibrosis JS1 cells TGF-¦Â1 treatment upregulated 30118889 214 Mouse mmu_circ_33736 circRNA IL-1¦Â osteoarthritis (OA) mouse articular chondrocytes (MACs) IL-1¦Â treatment downregulated 29247798 215 Mouse mmu_circ_34116 circRNA carbon tetrachloride (CCl4) liver fibrosis liver tissues carbon tetrachloride (CCl4) treatment downregulated 30118889 216 Mouse mmu_circ_34116 circRNA TGF-¦Â1 liver fibrosis JS1 cells TGF-¦Â1 treatment downregulated 30118889 217 Mouse mmu_circ_344 circRNA deoxycorticosterone acetate-salt hypertension hypertensive nephropathy (HN) kidney tissues deoxycorticosterone acetate-salt hypertension treatment downregulated 31782248 218 Mouse mmu_circ_35216 circRNA carbon tetrachloride (CCl4) liver fibrosis liver tissues carbon tetrachloride (CCl4) treatment upregulated 30118889 219 Mouse mmu_circ_35216 circRNA TGF-¦Â1 liver fibrosis JS1 cells TGF-¦Â1 treatment upregulated 30118889 220 Mouse mmu_circ_3591 circRNA deoxycorticosterone acetate-salt hypertension hypertensive nephropathy (HN) kidney tissues deoxycorticosterone acetate-salt hypertension treatment downregulated 31782248 221 Mouse mmu_circ_36866 circRNA IL-1¦Â osteoarthritis (OA) mouse articular chondrocytes (MACs) IL-1¦Â treatment upregulated 29247798 222 Mouse mmu_circ_36866 circRNA IL-1¦Â osteoarthritis (OA) mouse articular chondrocytes (MACs) IL-1¦Â treatment dysregulated 29247798 223 Mouse mmu_circ_40001 circRNA ischemia brain injury after stroke brain tissues treat with focal cerebral ischemia dysregulated 29156814 224 Mouse mmu_circ_40806 circRNA ischemia brain injury after stroke brain tissues treat with focal cerebral ischemia dysregulated 29156814 225 Mouse mmu_circ_42398 circRNA carbon tetrachloride (CCl4) liver fibrosis liver tissues carbon tetrachloride (CCl4) treatment downregulated 30118889 226 Mouse mmu_circ_5846 circRNA bone morphogenetic protein 2 (BMP2) osteogenesis Murine MC3T3-E1 osteoblastic cells bone morphogenetic protein 2 (BMP2) treatment upregulated 28395271 227 Mouse mmu_circ_662 circRNA astilbin lung fibrosis lung tissues astilbin induce dysregulated 31448882 228 Mouse mmu_circ_7063 circRNA IL-1¦Â osteoarthritis (OA) mouse articular chondrocytes (MACs) IL-1¦Â treatment upregulated 29247798 229 Mouse mmu_circ_818 circRNA deoxycorticosterone acetate-salt hypertension hypertensive nephropathy (HN) kidney tissues deoxycorticosterone acetate-salt hypertension treatment upregulated 31782248 230 Mouse mmu_circ_949 circRNA astilbin lung fibrosis lung tissues astilbin induce dysregulated 31448882