ID Species ncRNA ncRNA type Environmental factor (EF) Phenotype Sample Condition of EF Evidence PubMed ID 1 Rat chr1:142682098|142682602 circRNA hyperoxia bronchopulmonary dysplasia (BPD) lung tissues hyperoxia treatment downregulated 31961470 2 Rat chr1:87010380|87010777 circRNA hyperoxia bronchopulmonary dysplasia (BPD) lung tissues hyperoxia treatment downregulated 31961470 3 Rat chr15:67588477|67588841 circRNA hyperoxia bronchopulmonary dysplasia (BPD) lung tissues hyperoxia treatment downregulated 31961470 4 Rat chr18:49891333|49891588 circRNA hyperoxia bronchopulmonary dysplasia (BPD) lung tissues hyperoxia treatment downregulated 31961470 5 Rat chr19:9683854|9684128 circRNA hyperoxia bronchopulmonary dysplasia (BPD) lung tissues hyperoxia treatment downregulated 31961470 6 Rat chr5:90817794|90827570 circRNA TGF-¦Â1 epithelial-mesenchymal transition (EMT) rat coronary artery endothelial cells (CAEC) TGF-¦Â1 treatment upregulated 29521313 7 Rat chr6:22033342|22038870 circRNA TGF-¦Â1 epithelial-mesenchymal transition (EMT) rat coronary artery endothelial cells (CAEC) TGF-¦Â1 treatment upregulated 29521313 8 Rat chr8:71336875|71337745 circRNA hyperoxia bronchopulmonary dysplasia (BPD) lung tissues hyperoxia treatment downregulated 31961470 9 Rat chr8:71336875|71337745 circRNA TGF-¦Â1 epithelial-mesenchymal transition (EMT) rat coronary artery endothelial cells (CAEC) TGF-¦Â1 treatment upregulated 29521313 10 Rat circANKRD36 circRNA lipopolysaccharide (LPS) myocarditis H9c2 cells lipopolysaccharide (LPS) treatment upregulated 31442445 11 Rat circANXA2 circRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) treatment The expression of CircANXA2 was upregulated in H/R-treated H9c2 cells. 32685535 12 Rat circANXA2 circRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) treatment upregulated 32685535 13 Rat circBNIP3 circRNA hypoxia hypoxia-induced injury H9c2 cell hypoxia induce upregulated 31923741 14 Rat circCamk4 circRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia/reperfusion (I/R) injury primary neuronal cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 32332879 15 Rat circCDR1as circRNA 1-methyl-4-phenylpyridinium (MPP+) parkinson's disease (PD) PC12 cells 1-methyl-4-phenylpyridinium (MPP+) treatment upregulated 32889692 16 Rat circCDR1as circRNA exendin-4 (Ex-4) parkinson's disease (PD) 1-methyl-4-phenylpyridinium (MPP+)-treated PC12 cells Exendin-4 (Ex-4)?treatment downregulated 32889692 17 Rat circCDR1as circRNA exendin-4 (Ex-4) neuronal cell injury PC12 cells Exendin-4 (Ex-4) treatment Ex-4 downregulated 1-methyl-4 phenyl-pyridine ion (MPP+) -induced CDR1as expression in PC12 cells and upregulated miR-671 expression. 32889692 18 Rat circDENND2A circRNA oxygen glucose deprivation (OGD) myocardial infarction (MI) rat H9c2 cells oxygen glucose deprivation (OGD) treatment OGD upregulated circDENND2A expression in H9c2 cells 31878833 19 Rat circDENND2A circRNA oxygen glucose deprivation (OGD) myocardial infarction (MI) H9c2 cells oxygen glucose deprivation (OGD) treatment circDENND2A overexpression enhanced OGD-inhibited cell viability and migration but declined OGD-promoted apoptosis by downregulating miR-34a and via ¦Â-catenin and Ras/Raf/MEK/ERK pathways 31878833 20 Rat circDENND4C circRNA oxygen glucose deprivation (OGD) ischemic heart disease (IHD) H9c2 cells oxygen and glucose deprivation (OGD) treatment CircRNA-DENND4C was upregulated after OGD/R stimulation 33090893 21 Rat circDNMT3B circRNA streptozocin (STZ) diabetic retinopathy (DR) retinas tissues streptozotocin treatment downregulated 31636010 22 Rat circEIF4G2 circRNA high glucose (HG) diabetic nephropathy (DN) NRK-52E cells high glucose (HG) treatment upregulated 33615661 23 Rat circFADS2 circRNA lipopolysaccharide (LPS) cell proliferation chondrocytes lipopolysaccharide (LPS) treatment upregulated 31141496 24 Rat circHIPK3 circRNA caerulein (Cae) acute pancreatitis (AP) AR42J cells caerulein treatment "circHIPK3 promotes pyroptosis in acinar cells through regulation of the miR-193a-5p/GSDMD axis, which eventually aggravates AP disease." 32318575 25 Rat circHIPK3 circRNA CoCl2 spinal cord injury (SCI) PC12 cells CoCl2 treatment circ-HIPK3 relieves the neuronal cell apoptosis through regulating miR-588/DPYSL5 axis in SCI. 32247616 26 Rat circITCH circRNA H2O2 cardiovascular disease (CVD) H9c2 cells H2O2 treatment downregulated 33350543 27 Rat circLRP6 circRNA streptozocin (STZ) diabetes mellitus (DM) INS-1 cells streptozotocin (STZ) treatment The expression of circLRP6 was elevated while cell viability was decreased after INS-1 cells were exposed to STZ. 33826088 28 Rat circMAT2B circRNA oxygen glucose deprivation (OGD) myocardial infarction (MI) H9c2 cells Oxygen-glucose deprivation (OGD) treatment circMAT2B knockdown works as an inflammatory inhibitor in OGD-induced H9c2 cells inflammatory injury through up-regulating miR-133 32897801 29 Rat circNCX1 circRNA H2O2 ischemic heart disease (IHD) H9c2 cells H2O2 treatment A time-dependent increase in circNCX1 level was observed in H9c2 cells upon treatment with 100 ¦ÌM H2O2. 30187887 30 Rat circNFIX circRNA H2O2 myocardial infarction (MI) H9c2 cells oxidative stress treatment The expression of circNFIX was significantly downregulated in cardiomyocytes subjected to oxidative stress. 33067659 31 Rat circPan3 circRNA doxorubicin (DOX) doxorubicin (DOX)-induced cardiotoxicity H9c2 cells doxorubicin (Dox) treatment downregulated 32135167 32 Rat circPlekha7 circRNA Smad3 inhibitor (SIS3) intrauterine adhesion (IUA) endometrial stromal cell (ESC) SIS3 treatment CircPlekha7 was identified as one of the significantly upregulated circRNAs in the SIS3 group 32801258 33 Rat circPTK2 circRNA oxygen glucose deprivation (OGD) neuron apoptosis rat primary hippocampal microglial cells oxygen-glucose deprivation (OGD) induce treatment upregulated 30742923 34 Rat circPVT1 circRNA glucocorticoid (GC) steroid-induced osteonecrosis of femoral head (ONFH) bone marrow-derived mesenchymal stem cells (BMSCs) Glucocorticoid (GC)?treatment "We found that CircPVT1 was decreased in the femoral head of SIONFH rats and GC-treated BMSCs, while miR-21-5p was markedly upregulated." 33733589 35 Rat circSAMD4A circRNA hypoxia/reoxygenation (H/R) acute myocardial infarction (AMI) H9c2 cells hypoxia/reoxygenation (H/R) treatment circSAMD4A were upregulated after H/R induction. 33219594 36 Rat circSamd4a circRNA inorganic phosphate (Pi) vascular calcification (VC) rat vascular smooth muscle cells inorganic phosphate treatment "circSamd4a was downregulated after vascular calcification induction. While silencing circSamd4a promoted vascular calcification, overexpressing it reduced vascular calcification in calcium assay and Alizarin red S (ARS) staining." 31790973 37 Rat circSamd4a circRNA inorganic phosphate (Pi) vascular calcification (VC) Vascular Smooth Muscle Cells Inorganic phosphate (Pi) treatment downregulated 31790973 38 Rat circShank3 circRNA dexmedetomidine (DEX) postoperative cognitive dysfunction (POCD) Hippocampus dexmedetomidine (Dex) treatment circ-Shank3 participate in the process of Dex improved POCD through regulating the P53 and NF-¦ÊB signaling pathways. 32226705 39 Rat circTtc3 circRNA hypoxia apoptosis Neonatal rat ventricular myocytes (NRVMs) and fibroblasts hypoxia induce upregulated 30876857 40 Rat circTtc3 circRNA TGF-¦Â1 apoptosis Neonatal rat ventricular fibroblasts TGF-¦Â1 treatment upregulated 30876857 41 Rat circTTC3 circRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia/reperfusion (I/R) injury primary neural stem cells (NSCs) were obtained from rat embryos oxygen-glucose deprivation and reoxygenation (OGD/R) treatment the expression of circTTC3 was elevated in the MCAO/R mice and oxygen and glucose deprivation (OGD)-treated astrocytes 33579365 42 Rat circZNF292 circRNA oxygen-glucose deprivation and reoxygenation (OGD/R) hypoxic-ischemic encephalopathy (HIE) neural stem cells (NSCs) oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 32052645 43 Rat circZNF292 circRNA hypoxia ischemic heart disease (IHD) H9c2 cells hypoxia treatment "The production of the circZNF292 was promoted by OGD. Abundant circZNF292 released OGD-induced damage by up-regulating cell viability and Wnt3a/¦Â-catenin or mTOR proteins, but down-regulating apoptosis and autophagy." 31607209 44 Rat rno_circ_0000064 circRNA salidroside (SAL) ischemia/reperfusion (I/R) injury rat heart salidroside (SAL) treatment Sal treatment attenuated autophagy by up-regulating the expression of hsa_circ_0000064 (circ-0000064) and Rapamycin (RAPA) treatment abolished it 32858179 45 Rat rno_circ_0002074 circRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 46 Rat rno_circ_0002322 circRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 47 Rat rno_circ_0002640 circRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 48 Rat rno_circ_0003331 circRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 49 Rat rno_circ_0004153 circRNA iohexol contrast-induced acute kidney injury (CIAKI) Renal tissue "Animals were dehydrated for 48 h and then underwent furosemide (10 mL/kg; Harvest Pharmaceutical, Shanghai, China) injection 30 min before administration of iohexol (15 mL/kg, group CI-AKI; iodine, 350 mg/mL; GE Healthcare, Shanghai, China) or 0.9% normal saline (15 mL/kg, control group)." circRNA circ_0004153 was significantly upregulated in Contrast-induced acute kidney injury (CI-AKI). 31234008 50 Rat rno_circ_0004699 circRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 51 Rat rno_circ_0004849 circRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 52 Rat rno_circ_0004938 circRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 53 Rat rno_circ_0005139 circRNA 2-imidazolidinethione anorectal malformations (ARM) Intestinal epithelial cells; IECs and anorectal tissues 2-imidazolidinethione treatment "Rno_circ_0005139 influences cell proliferation and apoptosis by acting as a miR-324-3p sponge, thereby downregulating Wnt5a in ARM." 32848333 54 Rat rno_circ_0005972 circRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia treatment upregulated 31923741 55 Rat rno_circ_0006385 circRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 56 Rat rno_circ_0006567 circRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 57 Rat rno_circ_0007717 circRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 58 Rat rno_circ_0008082 circRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 59 Rat rno_circ_001372 circRNA propofol (PPF) propofol-induced neurotoxicity and neuroinflammation brain tissues; PC-12 cells propofol treatment The propofol anesthesia decreases the levels of rno_circ_001372 in vitro and vivo 32506974 60 Rat rno_circ_001555 circRNA amyloid-¦Â (A¦Â) 1-42 Alzheimer's disease (AD) hippocampus amyloid ¦Â1-42?(A¦Â) treatment upregulated 29706607 61 Rat rno_circ_002948 circRNA laminectomy plus contusion spinal cord injury (SCI) spinal cord laminectomy plus contusion treatment downregulated 30756390 62 Rat rno_circ_003593 circRNA Malva sylvestris L. (MS) ischemic heart disease (IHD) heart sissues Malva sylvestris L. (MS) treatment We noted that rat_circ_003593 (circ003593) was upregulated by I/ R injury and downregulated by MS pre-treatment. 33101012 63 Rat rno_circ_004806 circRNA lipopolysaccharide (LPS) sepsis aortic tissues lipopolysaccharide (LPS) treatment upregulated 32452125 64 Rat rno_circ_004930 circRNA lipopolysaccharide (LPS) sepsis aortic tissues lipopolysaccharide (LPS) treatment downregulated 32452125 65 Rat rno_circ_00534 circRNA laminectomy plus contusion spinal cord injury (SCI) spinal cord laminectomy plus contusion treatment downregulated 30756390 66 Rat rno_circ_005442 circRNA kaempferol depression hippocampus Kaempferol (Kae) treatment downregulated 31898506 67 Rat rno_circ_0054633 circRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues lipopolysaccharide (LPS) treatment upregulated 32950633 68 Rat rno_circ_005564 circRNA lipopolysaccharide (LPS) acute respiratory distress syndrome (ARDS) rats lung tissues lipopolysaccharide (LPS) treatment dysregulated 28864418 69 Rat rno_circ_006096 circRNA laminectomy plus contusion spinal cord injury (SCI) spinal cord laminectomy plus contusion treatment downregulated 30756390 70 Rat rno_circ_0062389 circRNA hypoxia/reoxygenation (H/R) heart failure (HF) H9c2 cells hypoxia/reoxygenation (H/R) treatment Silencing circ_0062389 alleviates cardiomyocyte apoptosis in heart failure rats via modulating TGF-¦Â1/Smad3 signaling pathway 32949699 71 Rat rno_circ_008634 circRNA lipopolysaccharide (LPS) sepsis aortic tissues lipopolysaccharide (LPS) treatment downregulated 32452125 72 Rat rno_circ_008728 circRNA lipopolysaccharide (LPS) sepsis aortic tissues lipopolysaccharide (LPS) treatment upregulated 32452125 73 Rat rno_circ_010219 circRNA lipopolysaccharide (LPS) sepsis aortic tissues lipopolysaccharide (LPS) treatment downregulated 32452125 74 Rat rno_circ_010489 circRNA lipopolysaccharide (LPS) acute respiratory distress syndrome (ARDS) rats lung tissues lipopolysaccharide (LPS) treatment dysregulated 28864418 75 Rat rno_circ_010684 circRNA amyloid-¦Â (A¦Â) 1-42 Alzheimer's disease (AD) hippocampus amyloid ¦Â1-42?(A¦Â) treatment upregulated 29706607 76 Rat rno_circ_011426 circRNA lipopolysaccharide (LPS) acute respiratory distress syndrome (ARDS) rats lung tissues lipopolysaccharide (LPS) treatment dysregulated 28864418 77 Rat rno_circ_013017 circRNA laminectomy plus contusion spinal cord injury (SCI) spinal cord laminectomy plus contusion treatment downregulated 30756390 78 Rat rno_circ_013981 circRNA amyloid-¦Â (A¦Â) 1-42 Alzheimer's disease (AD) hippocampus amyloid ¦Â1-42?(A¦Â) treatment downregulated 29706607 79 Rat rno_circ_014900 circRNA kaempferol depression hippocampus Kaempferol (Kae) treatment upregulated 31898506 80 Rat rno_circ_015513 circRNA laminectomy plus contusion spinal cord injury (SCI) spinal cord laminectomy plus contusion treatment downregulated 30756390 81 Rat rno_circ_016014 circRNA lipopolysaccharide (LPS) sepsis aortic tissues lipopolysaccharide (LPS) treatment upregulated 32452125 82 Rat rno_circ_017418 circRNA lipopolysaccharide (LPS) sepsis aortic tissues lipopolysaccharide (LPS) treatment downregulated 32452125 83 Rat rno_circ_017759 circRNA amyloid-¦Â (A¦Â) 1-42 Alzheimer's disease (AD) hippocampus amyloid ¦Â1-42?(A¦Â) treatment downregulated 29706607 84 Rat rno_circ_19423 circRNA lipopolysaccharide (LPS) acute respiratory distress syndrome (ARDS) rats lung tissues lipopolysaccharide (LPS) treatment dysregulated 28864418 85 Rat rno_circ_30664 circRNA lipopolysaccharide (LPS) acute respiratory distress syndrome (ARDS) rats lung tissues lipopolysaccharide (LPS) treatment dysregulated 28864418 86 Rat rno_circ_68566 circRNA ischemia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells ischemia buffer treatment circ-0068566 inhibited the development of myocardial ischemia reperfusion injury by regulating hsa-miR-6322/PARP2 signal pathway. 32633392