ID Species ncRNA ncRNA type Environmental factor (EF) Phenotype Sample Condition of EF Evidence PubMed ID 1 Rat AABR07037489.1 lncRNA nickel steroidogenesis disturbance Leydig cells NiSO4 induce dysregulated 31734292 2 Rat AABR07037489.1 lncRNA NiSO4 steroidogenesis disturbance rat Leydig cells NiSO4 treatment downregulated 31734292 3 Rat AABR07070307.1 lncRNA NiSO4 steroidogenesis disturbance rat Leydig cells NiSO4 treatment downregulated 31734292 4 Rat Abcf2-004 lncRNA letrozole polycystic ovarian syndrome (PCOS) ovarian tissues letrozole treatment upregulated 29505837 5 Rat Adgrv1-003 lncRNA letrozole polycystic ovarian syndrome (PCOS) ovarian tissues letrozole treatment upregulated 29505837 6 Rat AF159100 lncRNA angiotensin II (Ang II) cardiac fibrosis Sprague-Dawley (SD) rats angiotensin II (Ang II) treatment upregulated 24817929 7 Rat AF230638 lncRNA aldosterone chronic kidney disease (CKD) mesangial cells (MCs) aldosterone treatment downregulated 28849035 8 Rat AF336872 lncRNA aldosterone chronic kidney disease (CKD) mesangial cells (MCs) aldosterone treatment upregulated 28849035 9 Rat AJ005396 lncRNA bleomycin (BLM) lung fibrosis fibrotic lung tissues bleomycin (BLM) treatment upregulated 23732278 10 Rat AK003290 lncRNA tanshinone IIA (Tan IIA) acute myocardial infarction (AMI) H9c2 cells Tanshinone IIA (TSA) treatment "TSA exerts the protective role against H/R induced apoptosis, oxidative and MMP loss of cardiomyocytes via regulating AK003290 and miR-124-5p signaling" 32220226 11 Rat AK046177 lncRNA Safflor yellow B (SYB) stroke cortical cells Safflor yellow B (SYB) treatment Safflor Yellow B Attenuates Ischemic Brain Injury via downregulated of Long Noncoding AK046177 and Inhibition of MicroRNA-134 Expression in Rats 32566081 12 Rat AK12348 lncRNA anoxia/reoxygenation (A/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells anoxia/reoxygenation (A/R) treatment "The relative level of lncRNA AK12348, LDH release and cell apoptotic rate in A/R cardiomyocytes was significantly higher than that in normal cardiomyocytes." 29398472 13 Rat AK12348 lncRNA anoxia/reoxygenation (A/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) rat cardiomyocyte H9C2 anoxia/reoxygenation (A/R) treatment upregulated 29398472 14 Rat AK123702 lncRNA hypoxia gastric cancer (GC) GC cells hypoxia treatment upregulated 26884908 15 Rat AK139128 lncRNA hypoxia myocardial infarction (MI) cardiomyocytes hypoxia treatment hypoxia upregulated the level of AK139128 in CMs and exosomes and exosomal AK139128 derived from hypoxic CMs modulated cellular activities of CFs in vitro and in vivo. 32494135 16 Rat ANRIL lncRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia induce upregulated 31264206 17 Rat ANRIL lncRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia treatment ANRIL plays a protective part in hypoxia-induced H9c2 cell injury via modulating the miR-7-5p/SIRT1 axis 31264206 18 Rat ANRIL lncRNA oxygen glucose deprivation (OGD) ischemic stroke (IS) rat adrenal medulla-derived pheochromocytoma cell line PC-12 oxygen-glucose deprivation (OGD) induce treatment OGD-induced PC-12 cell injury and decreased ANRIL expression 31174432 19 Rat Atat1 lncRNA NiSO4 steroidogenesis disturbance rat Leydig cells NiSO4 treatment downregulated 31948324 20 Rat ATB lncRNA amyloid-¦Â (A¦Â) 25-35 Alzheimer's disease (AD) PC12 cells amyloid-¦Â (A¦Â) 25-35 treatment A¦Â 25-35-induced injury in PC12 cells and increased the expression of lncRNA-ATB. 30248538 21 Rat AX765700 lncRNA angiotensin II (Ang II) cardiac fibrosis Sprague-Dawley (SD) rats angiotensin II (Ang II) treatment upregulated 24817929 22 Rat AY325162 lncRNA aldosterone chronic kidney disease (CKD) mesangial cells (MCs) aldosterone treatment upregulated 28849035 23 Rat BACE1-AS lncRNA 6-hydroxydopamine (6-OHDA) parkinson's disease (PD) substantia nigra 6-hydroxydopamine (6-OHDA) treatment downregulated of lncRNA BACE1-AS inhibits iNOS activation in the substantial nigra and improve oxidative stress injury in PD rats by upregulating miR-34b-5p and downregulating BACE1. 32308102 24 Rat BC079195 lncRNA manganese (Mn) neurotoxicity hippocampal neurons Manganese (Mn) treatment upregulated 26745496 25 Rat BC086588 lncRNA angiotensin II (Ang II) cardiac fibrosis Sprague-Dawley (SD) rats angiotensin II (Ang II) treatment upregulated 24817929 26 Rat BC088254 lncRNA aldosterone chronic kidney disease (CKD) mesangial cells (MCs) aldosterone treatment upregulated 28849035 27 Rat BC089928 lncRNA manganese (Mn) neurotoxicity hippocampal neurons Manganese (Mn) treatment downregulated 26745496 28 Rat BC092207 lncRNA subarachnoid hemorrhage (SAH) early brain injury (EBI) brain subarachnoid hemorrhage (SAH) treatment upregulated 25777551 29 Rat BC167085 lncRNA aldosterone chronic kidney disease (CKD) mesangial cells (MCs) aldosterone treatment downregulated 28849035 30 Rat BC168211 lncRNA aldosterone chronic kidney disease (CKD) mesangial cells (MCs) aldosterone treatment upregulated 28849035 31 Rat BC168687 lncRNA aldosterone chronic kidney disease (CKD) mesangial cells (MCs) aldosterone treatment upregulated 28849035 32 Rat BC168687 lncRNA streptozocin (STZ) diabetic neuropathic pain (DNP) rats DRG injected intraperitoneally with a dosage of 30?mg/kg streptozotocin (STZ) solution treatment upregulated 29204447 33 Rat BCYRN1 lncRNA platelet derived growth factor-BB (PDGF-BB) asthma airway smooth muscle cells (ASMCs) isolated from SD rat platelet-derived growth factor-BB (PDGF-BB) treatment upregulation 27648131 34 Rat BDNF-AS lncRNA hypoxia acute spinal cord injury (ASCI) AGE1.HN cells; PC12 cells hypoxia treatment "BDNF-AS, PRDM5 and c-caspase 3 expression were significantly upregulated, while miR-130b-5p was suppressed in the ASCI group and neuronal cells following hypoxia treatment." 29995562 35 Rat BDNF-AS lncRNA amyloid-¦Â (A¦Â) 25-35 Alzheimer's disease (AD) PC12 cells amyloid-¦Â (A¦Â) 25-35 treatment A¦Â 25-35 apparently increased BDNF-AS but decreased BDNF in PC12 cells. 29902125 36 Rat BDNF-AS lncRNA lithium (Li) spinal cord injury (SCI) spinal cord lithium treatment "Furthermore, lithium treatment alleviated the inflammatory response by inactivating the nuclear factor-kappa B (NF-¦ÊB) pathway and inhibited the expression of lncRNA brain-derived neurotrophic factor antisense (BDNF-AS) in SCI rats." 33464390 37 Rat BLACAT1 lncRNA IL-6 osteogenesis bone marrow stromal stem cells (BMSCs) IL-6 treatment "BLACAT1 expression was increased in inflammatory BMSCs, and knockdown of BLACAT1 promoted proliferation and osteogenic differentiation of BMSCs targeting miR-142-5p." 32271407 38 Rat Blnc1 lncRNA streptozocin (STZ) diabetic nephropathy (DN) renal tissues streptozotocin (STZ) treatment upregulated 31632538 39 Rat Bmncr lncRNA macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-¦ÊB ligand (RANKL) osteoporosis Bone marrow mesenchymal stem cells (BMMs) isolated from rats undergoing ovariectomy (OVX) RANKL (50 ng/mL) and M-CSF (50 ng/mL) for 120 h treatment Bmncr expression gradually downregulated during RANKL-induced in vitro osteoclast differentiation 31773670 40 Rat CASC2 lncRNA pentylenetetrazol (PTZ) epilepsy hippocampus tissues pentylenetetrazol (PTZ) treatment lncRNA CASC2 was time-dependently downregulated in the epileptic groups compared with the control group 31958564 41 Rat CASC2 lncRNA hypoxia hypoxic pulmonary hypertension (HPH) pulmonary arterial tissues and pulmonary artery smooth muscle cells (PASMCs) hypoxia induce downregulated 30857524 42 Rat CASC9 lncRNA lipopolysaccharide (LPS) lung injury lung tissues Lipopolysaccharide (LPS) treatment CASC9 was markedly downregulated while miR-195-5p was significantly upregulated in HSAECs treated by LPS and lung tissues of rats with sepsis. 32221619 43 Rat CASC9 lncRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC-12 cells lipopolysaccharide (LPS) treatment The results showed that lncRNA CASC9 was downregulated and miR-383-5p was upregulated in SCI rats and LPS-induced PC12 cells. 33438067 44 Rat CCAT1 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) spinal cord injury (SCI) astrocytes oxygen-glucose deprivation and reoxygenation (OGD/R) treatment CCAT1 Protects Astrocytes Against OGD/R-Induced Damage by Targeting the miR-218/NFAT5-Signaling Axis 32239388 45 Rat CD36-005 lncRNA letrozole polycystic ovarian syndrome (PCOS) ovarian tissues letrozole treatment upregulated 29505837 46 Rat Cdkn1 lncRNA angiotensin II (Ang II) cardiac fibrosis cardiac angiotensin II (Ang II) treatment downregulated 25979571 47 Rat Cdkn1 lncRNA losartan cardiac fibrosis heart tissues Losartan treatment "losartan (AT1 blocker) nearly completely reversed the decrease of lncRNA-NR024118 and partly reversed the decrease of Cdkn1c induced by Ang II in adult rat cardiac fibroblasts," 25979571 48 Rat CHAR lncRNA angiotensin II (Ang II) cardiac hypertrophy neonatal rat ventricular cells (NRVCs) angiotensin II (Ang II) treatment CHAR was also down©\regulated in AngII©\treated NRVCs. CHAR participates in pathological cardiac hypertrophy in vitro. CHAR regulates cardiac hypertrophy via the miR©\20b/PTEN/AKT pathway. 31465630 49 Rat CHRF lncRNA lipopolysaccharide (LPS) myocarditis H9c2 cells lipopolysaccharide (LPS) treatment "?Silence of lncRNA CHRF impeded the LPS injury to H9c2 cells, as cell viability was increased, apoptosis was inhibited, ROS generation was decreased, and the expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-¦Á was suppressed. However, silence of lncRNA CHRF had no impacts on normal H9c2 cells growth." 30695715 50 Rat CPS1©\IT lncRNA hypoxia pulmonary arterial hypertension (PAH) pulmonary artery tissues hypoxia induce downregulated 30982984 51 Rat CRNDE lncRNA lipopolysaccharide (LPS) intrauterine infection brain tissues lipopolysaccharide (LPS) treatment CRNDE deteriorates intrauterine infection-induced neonatal brain injury 32234564 52 Rat CRNDE lncRNA lipopolysaccharide (LPS) myocardial injury H9c2 cells lipopolysaccharide (LPS) treatment CRNDE/miR-29a/SIRT1 network regulated sepsis-induced myocardial injury. 32473249 53 Rat CRNDE lncRNA platelet derived growth factor-BB (PDGF-BB) restenosis after angioplasty or stent rat carotid artery and vascular smooth muscle cells (VSMCs) platelet-derived growth factor-BB (PDGF-BB) treatment upregulated 30740670 54 Rat CRNDE lncRNA feeney's freefall impact traumatic brain injury (TBI) brain tissues Feeney's freefall impact induce upregulated 31345079 55 Rat CTPB1-AS2 lncRNA angiotensin II (Ang II) cardiac hypertrophy The neonatal rat ventricular myocytes (NRVMs) angiotensin II (Ang II) treatment upregulated 31220774 56 Rat CUST-2117-PI428311958 lncRNA high fat diet (HFD) obesity rats high fat diet (HFD) feed upregulated 28761781 57 Rat CUST-4640-PI428311958 lncRNA high fat diet (HFD) obesity rats high fat diet (HFD) feed upregulated 28761781 58 Rat CUST-5105-PI428311958 lncRNA high fat diet (HFD) obesity rats high fat diet (HFD) feed upregulated 28761781 59 Rat CUST-6638-PI428311958 lncRNA high fat diet (HFD) obesity rats high fat diet (HFD) feed upregulated 28761781 60 Rat CUST-9613-PI428311958 lncRNA high fat diet (HFD) obesity rats high fat diet (HFD) feed upregulated 28761781 61 Rat CYTOR lncRNA lipopolysaccharide (LPS) myocardial injury H9c2 cells lipopolysaccharide (LPS) treatment upregulated 32181504 62 Rat DANCR lncRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia treatment DANCR alleviated hypoxia-caused H9c2 cells damage through positive regulation of HIF-1¦Á. 33426962 63 Rat DANCR lncRNA compression force (CF) cell differentiation human periodontal ligament (PDL) cells compression force (CF) treatment upregulated 31213122 64 Rat DANCR lncRNA tunicamycin (TM) endoplasmic reticulum stress (ERS) H9c2 cells tunicamycin treatment lncRNA Dancr overexpression protected cardiomyocytes against ERS injury via sponging miR-6324. 33300079 65 Rat DANCR lncRNA oxygen glucose deprivation (OGD) ischemic stroke (IS) brain microvascular endothelial cell (BMEC) oxygen glucose deprivation (OGD) treatment "DANCR expression significantly increased at 2, 4, 6, 8, and 10 h after OGD." 31986122 66 Rat DCRF lncRNA high glucose (HG) diabetic cardiomyopathy (DCM) neonatal rats cardiomyocytes high glucose (HG) treatment High glucose increased DCRF expression and induced autophagy in cardiomyocytes. 31285779 67 Rat DCRF lncRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) rat heart tissues streptozotocin treatment "DCRF knockdown reduced cardiomyocyte autophagy, attenuated myocardial fibrosis, and improved cardiac function in diabetic rats" 31285779 68 Rat DGCR5 lncRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia induce downregulated 31826181 69 Rat DGCR5 lncRNA polydatin (PD) myocardial infarction (MI) hypoxia-induced H9c2 cells Polydatin (PD) treatment upregulated 31826181 70 Rat DGCR5 lncRNA hypoxia spinal cord injury (SCI) PC12 cells hypoxia treatment DGCR5 was downregulated in PC12 cells treated with hypoxia. 30146926 71 Rat Dlg4 lncRNA lipopolysaccharide (LPS) hepatocarcinogenesis WB-F344 cells lipopolysaccharide (LPS) treatment upregulated 31065105 72 Rat EFNA3 lncRNA hypoxia cerebral ischemia injury (CII) hypoxia-injured rat adrenal pheochromocytoma (PC-12) cells hypoxia induce "?lncRNA EFNA3 was highly expressed in response to hypoxia. Deletion of lncRNA EFNA3 significantly aggravated hypoxia-induced injury in PC-12 cells, as the impairment of cell viability, migration, and invasion, and the inducement of apoptosis. LncRNA EFNA3 worked as a sponging molecule for miR-101a and miR-101a suppression-protected PC-12 cells against hypoxia-induced injury even when lncRNA EFNA3 was silenced." 30125989 73 Rat EFNA3 lncRNA hypoxia cerebral ischemia injury (CII) PC-12 cells hypoxia treatment lncRNA EFNA3 was highly expressed in response to hypoxia. 30125989 74 Rat EGOT lncRNA recombinant human brain natriuretic peptide (rhBNP) hypoxia-induced injury H9c2 cells recombinant human brain natriuretic peptide (rhBNP) treatment Hypoxia significantly induced injury in H9c2 cells (inhibited cell viability and promoted cell apoptosis and autophagy) and decreased the expression of EGOT 30031611 75 Rat Eif4g2 lncRNA palmitate pancreatic ¦Â-cell dysfunction INS-1E cells palmitate treatment lncEif4g2 is able to indirectly regulate the expression of CREB via targeting miR-3074-5p in INS-1E cells and mouse islets 32956705 76 Rat Ell2 lncRNA lipopolysaccharide (LPS) hepatocarcinogenesis WB-F344 cells lipopolysaccharide (LPS) treatment upregulated 31065105 77 Rat ENSRNOG00000037522 lncRNA streptozocin (STZ) epithelial-mesenchymal transition (EMT) kidney tissues streptozocin (STZ) treatment ENSRNOG00000037522 was significantly increased in kidney tissues 29436579 78 Rat ENSRNOT00000065561 lncRNA chronic intermittent hypoxia (CIH) obstructive sleep apnea-induced cardiovascular disease heart tissues chronic intermittent hypoxia (CIH) treatment upregulated 30535531 79 Rat ENST00000052577 lncRNA A2B5+ cell transplantation traumatic brain injury (TBI) TBI Sprague-Dawley rats A2B5+ cell transplantation upregulated 29251113 80 Rat ENST00000446135 lncRNA cadmium (Cd) cadmium-induced toxicity lung tissues cadmium (Cd) treatment upregulated 33447366 81 Rat FAF lncRNA hypoxia acute myocardial infarction (AMI) Cardiomyocytes were isolated from 1©\ to 3©\day©\old rats hypoxia induce downregulated 31093967 82 Rat FAF lncRNA angiotensin II (Ang II) cardiac fibrosis cardiac fibroblasts (CFs); heart tissues angiotensin II (Ang II) treatment lncRNA FAF was decreased in heart tissues and CFs treated with Ang II compared with the control. 31708099 83 Rat FAM83H-AS1 lncRNA advanced glycation end product (AGE) intervertebral disc degeneration (IDD) nucleus pulposus (NP) cells advanced glycation end products (AGEs) treatment downregulated 33313263 84 Rat Fendrr lncRNA caerulein (Cae) acute pancreatitis (AP) AR42J cells caerulein (Cae) treatment LncRNA Fendrr was also upregulated in AP cell model and directly bound ANXA2 protein. 30474876 85 Rat Fendrr lncRNA hypoxia cardiomyocyte apoptosis H9c2 cells hypoxia treatment LncRNA Fendrr inhibits hypoxia/reoxygenation-induced cardiomyocyte apoptosis by downregulating p53 expression. 32537758 86 Rat FGD5-AS1 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) primary cortical neuron culture oxygen-glucose deprivation and reoxygenation (OGD/R) treatment FGD5-AS1 may protect the neuron against OGD/R injury via acting as a ceRNA for miR-223 to mediate IGF1R expression 32337949 87 Rat FIRRE lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) stroke primary microglial cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment FIRRE was upregulated in OGD/R-treated microglial cells 29715458 88 Rat FOXD3-AS1 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 31632535 89 Rat FTX lncRNA lithium chloride and pilocarpine epilepsy hippocampal neuron lithium chloride and pilocarpine induce "?FTX is notably reduced in the hippocampus of SE rat model. Moreover, the in?vivo overexpression of FTX inhibited SE-induced hippocampus neuron apoptosis." 30871773 90 Rat FTX lncRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells hypoxia/reoxygenation (H/R) treatment FTX alleviates hypoxia/reoxygenation-induced cardiomyocyte injury via miR-410-3p/Fmr1 axis 31957854 91 Rat FTX lncRNA Nogo-66 neurite outgrowth PC12 cells Nogo-66 treatment LncRNA FTX Involves in the Nogo-66-Induced Inhibition of Neurite Outgrowth Through Regulating PDK1/PKB/GSK-3¦Â Pathway. 32107749 92 Rat Gadd45a lncRNA sevoflurane (SEV) sevoflurane-induced neurotoxicity neural stem cells (NSCs) sevoflurane treatment lncRNA Gadd45a were positively coupregulated in rat NSCs fol- lowing exposure to sevoflurane 29521679 93 Rat gadd7 lncRNA agmatine (AGM) hyperoxia-induced acute lung injury (HALI) rat lung tissues agmatine (AGM) treatment "AGM decreased the upregulated expression of lncRNA gadd7 caused by hyperoxia and due to the presence of the competitive binding of lncRNA gadd7 and MFN1 to miR-125a, AGM indirectly decreased MFN1 protein expression to inhibit the cells apoptosis." 31196629 94 Rat GAS5 lncRNA isoproterenol acute myocardial infarction (AMI) rat myocardial tissues subcutaneous injection of isoproterenol (ISO) "SiRNA GAS5 can enhance the cardiac function of AMI model rats, relieve pathological damage, reduce myocardial cell apoptosis, and inhibit the occurrence of myocardial fibrosis. The possible underlying mechanism may be associated with upregulated of miR-21." 31646590 95 Rat GAS5 lncRNA bisphenol A (BPA) bisphenol A (BPA) induced neurotoxicity PC12cells bisphenol A (BPA) treatment GAS5 was downregulated in PC12 cells induced by BPA. 29552716 96 Rat GAS5 lncRNA hypoxia/reoxygenation (H/R) cardiomyocyte apoptosis H9c2 cells hypoxia/reoxygenation (H/R) treatment "LncRNA-GAS5 regulates PDCD4 expression to mediate MI-induced cardiomyocyte apoptosis via targeting miR-21, suggesting that GAS5 could be a therapeutic target for MI." 32308118 97 Rat GAS5 lncRNA homocysteine (Hcy) cell damage primary cardiac microvascular endothelial cells (CMECs) homocysteine (HCY) treatment downregulated 30825202 98 Rat GAS5 lncRNA deep hypothermic circulatory arrest cerebral injury rat hippocampal tissues deep hypothermic circulatory arrest treatment upregulated 30824348 99 Rat GAS5 lncRNA high glucose (HG) diabetic cardiomyopathy (DCM) AC16 cardiomyocytes high glucose (HG) treatment GAS5 expression was upregulated in HG-treated AC16 cardiomyocytes and the rat diabetic myocardial injury model 33682891 100 Rat GAS5 lncRNA high glucose (HG) diabetic cardiomyopathy (DCM) H9c2 cells high glucose (HG) treatment "GAS5 downregulated high blood glucose concentrations in STZ-induced diabetic rats, however its expression levels decreased in both HG-processed H9C2 cells and the myocardium of DM model rats." 33313941 101 Rat GAS5 lncRNA high glucose (HG) diabetic cardiomyopathy (DCM) H9c2 cells high glucose (HG) treatment downregulated 33313941 102 Rat GAS5 lncRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) H9c2 cells streptozotocin (STZ) treatment "GAS5 downregulated high blood glucose concentrations in STZ-induced diabetic rats, however its expression levels decreased in both HG-processed H9C2 cells and the myocardium of DM model rats" 33313941 103 Rat GAS5 lncRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) myocardium streptozotocin (STZ) treatment downregulated 33313941 104 Rat GAS5 lncRNA kainic acid (KA) epilepsy primary hippocampal neuron kainic acid (KA) treatment "lncRNA GAS5 functions as a competitive endogenous RNA of miR-135a-5p to increase expression of KCNQ3, and lncRNA GAS5 silencing inhibited the occurrence and progression of epilepsy." 31373759 105 Rat GAS5 lncRNA astragaloside IV (AS-IV) heart failure (HF) hypoxia-treated cardiomyoblast H9c2 cells astragaloside IV (AS-IV) treatment "we found that lncRNA GAS5 expression was downregulated by AS-IV treatment, and AS-IV might affect hypoxia-stimulated H9c2 cells through lncRNA GAS5." 31136949 106 Rat GAS5 lncRNA hypoxia heart failure (HF) H9c2 cells hypoxia induce "silence of lncRNA GAS5 attenuated hypoxia-triggered cell death, silence of lncRNA GAS5 protected H9c2 cells against hypoxia-induced injury possibly via sponging miR-142-5p." 31085811 107 Rat GAS5 lncRNA carbon tetrachloride (CCl4) liver fibrosis Liver tissues carbon tetrachloride (CCl4) treatment lncRNA GAS5 can be used as a sponge platform for miR-23a to decrease miR-23a expression levels competitively. 30735452 108 Rat GAS5 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) brain tissues oxygen-glucose deprivation and reoxygenation (OGD/R) treatment GAS5 and PTEN expression levels were elevated in brain tissues of MCAO rats and OGD/R-induced PC12 cells 33309710 109 Rat GAS5 lncRNA hypoxia myocardial infarction (MI) myocardial cell line H9c2 hypoxia induce upregulated 31429119 110 Rat GAS5 lncRNA norepinephrine (NE) myocardial infarction (MI) H9c2 cells Norepinephrine (NE) treatment upregulated 30099044 111 Rat GAS5 lncRNA anoxia/reoxygenation (A/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells anoxia/reoxygenation (A/R) treatment lncRNA GAS5 in H9c2 cells treated with anoxia and reoxygenation was significantly upregulated. 31985016 112 Rat GAS5 lncRNA palmitic acid (PA) myocardial lipotoxic injury H9c2 cells palmitic acid (PA) treatment GAS5 was significantly upregulated in cardiomyocytes following treatment with PA 30365114 113 Rat GAS5 lncRNA cocaine neural function nucleus accumbens (NAc) cocaine treatment downregulated 32711952 114 Rat GAS5 lncRNA methamphetamine (METH) neurotoxicity prefrontal cortical neurons Methamphetamine treatment upregulated 28619521 115 Rat GAS5 lncRNA curcumin (Cur) post-stroke depression (PSD) hippocampus curcumin treatment upregulated 32627518 116 Rat GAS5 lncRNA hypoxia stroke rat brain tissues Transient focal ischemia was induced by intraluminal occlusion of the right Middle cerebral artery occlusion (MCAO) "GAS5 was upregulated in MCAO rats and in vitro hypoxia cell model while miR-221 expression was decreased in vitro hypoxia cell model. GAS5 promoted cells apoptosis, while miR-221 inhibited cell apoptosis through regulation of PUMA and downstream JNK/H2AX signaling." 31878844 117 Rat Giver lncRNA angiotensin II (Ang II) hypertension Rat vascular smooth muscle cell (VSMC) angiotensin II (Ang II) treatment upregulated 30566058 118 Rat Giver lncRNA angiotensin II (Ang II) hypertension vascular smooth muscle cell (VSMC) angiotensin II (Ang II) treatment AngII increased the expression of Giver. 30566058 119 Rat Gm2691 lncRNA hypoxia acute myocardial infarction (AMI) neonatal rat ventricular cardiomyocytes AnaeroPack anaerobic system treatment LncRNA Gm2691 improved the cardiac function and attenuated the inflammatory response in vivo 31169981 120 Rat Gm4419 lncRNA hypoxia/reoxygenation (H/R) hepatic ischemia/reperfusion injury (HIRI) BRL-3A cells hypoxia-reoxygenation (H/R) treatment lncRNA Gm4419 accelerates hepatic I/R injury by targeting the miR-455-SOX6 axis. 32114773 121 Rat Gm4419 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) microglial cells from SD rat oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 28476620 122 Rat Gm4419 lncRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H92c cells hypoxia/reoxygenation treatment upregulated 32590403 123 Rat Gpr19 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) acute myocardial infarction (AMI) rat ventricular cardiomyocytes (NRCMs) oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 31622017 124 Rat Gpr19 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) Neonatal rat ventricular cardiomyocytes (NRCMs) oxygen-glucose deprivation and reoxygenation (OGD/R) treatment Inhibition of the LncRNA Gpr19 attenuates ischemia-reperfusion injury after acute myocardial infarction by inhibiting apoptosis and oxidative stress via the miR-324-5p/Mtfr1 axis. 31622017 125 Rat Grik2-001 lncRNA letrozole polycystic ovarian syndrome (PCOS) ovarian tissues letrozole treatment downregulated 29505837 126 Rat H19 lncRNA hypoxia acute myocardial infarction (AMI) rat H9c2 cells hypoxia upregulated 29179202 127 Rat H19 lncRNA lipopolysaccharide (LPS) acute respiratory distress syndrome (ARDS) lung tissues lipopolysaccharide (LPS) treatment "The expression of H19 and FOXA1 was significantly upregulated, while the expression of miR-423-5p was downregulated in LPS-induced ARDS rats." 33629893 128 Rat H19 lncRNA amyloid-¦Â (A¦Â) 25-35 Alzheimer's disease (AD) PC12 cells amyloid-¦Â (A¦Â) 25-35 treatment "Elevated H19, HMGB1 and decreased miR-129 were found in A¦Â25-35-treated PC12 cells as well as in brain tissues of AD mice." 33410377 129 Rat H19 lncRNA "2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)" ancestral TCDD exposure ovary of TCDD treated F3 female rats Pregnant Sprague-Dawley female rats (F0) were given with either vehicle or TCDD (100 or 500?ng/kg BW/day) by gavages during days 8-14 of gestation. upregulated 31629011 130 Rat H19 lncRNA hypoxia cardiac rehabilitation H9c2 cells hypoxic preconditioning (HPC) treatment "HPC treatment protected H9c2 cells against H2O2-induced injury, upregulated the level of long noncoding RNA (lncRNA) H19." 33197240 131 Rat H19 lncRNA hypoxia cerebral ischemia/reperfusion (I/R) injury brain tissues (lncRNA H19) was found to be upregulated by hypoxia upregulated 28203482 132 Rat H19 lncRNA streptozocin (STZ) diabetes mellitus (DM) rats renal tubular epithelial cells streptozotocin treatment upregulated 29029394 133 Rat H19 lncRNA high glucose (HG) and lipid diet diabetic foot ulcer (DFU) ulcer tissues high glucose and lipid diet lncRNA H19 accelerated wound healing in DFU through elevation of CTGF and activation of the MAPK signaling pathway. 32698141 134 Rat H19 lncRNA adriamycin (ADR) dilated cardiomyopathy (DCM) rats?myocardial tissue adriamycin (ADR) treatment upregulated 28430627 135 Rat H19 lncRNA hindlimb unloading (HLU) disuse osteoporosis (DOP) rats HLU treatment downregulated 28447380 136 Rat H19 lncRNA intra-amygdala kainic acid epilepsy hippocampus intra-amygdala kainic acid treatment H19 is involved in astrocyte activation in the hippocampus of epileptic rats. 30314521 137 Rat H19 lncRNA kainic acid (KA) epilepsy rat hippocampus neurons kainic acid treatment LncRNA H19 could competitively bind to let-7b to promote hippocampal glial cell activation and epileptic seizures by targeting Stat3 in a rat model of temporal lobe epilepsy. 32648622 138 Rat H19 lncRNA hypoxia hypoxic brain injury PC-12 cell hypoxia induce "Hypoxia-induced cell damage was aggravated by lncRNA H19 overexpression, while was alleviated by lncRNA H19 silence." 30312698 139 Rat H19 lncRNA geniposide (GEN) hypoxic/ischemic brain damage (HIBD) oxygen and glucose deprivation (OGD)-treated PC-12 cells Geniposide (GEN) treatment upregulated 30472296 140 Rat H19 lncRNA hypoxia hypoxic/ischemic brain damage (HIBD) PC-12 cells oxygen and glucose deprivation (OGD) downregulated 30472296 141 Rat H19 lncRNA geniposide (GEN) hypoxic-ischemic encephalopathy (HIE) PC-12 cells geniposide (GEN) treatment H19 expression was upregulated by GEN. 30472296 142 Rat H19 lncRNA hypoxia ischemic stroke (IS) rat brain tissues middle cerebral artery occlusion/reperfusion (MCAO/R) injury upregulated 31170091 143 Rat H19 lncRNA oxygen glucose deprivation (OGD) ischemic stroke (IS) rat neuronal cells oxygen glucose deprivation (OGD) treatment upregulated 31170091 144 Rat H19 lncRNA hypoxia myocardial infarction (MI) rat cardiomyocyte hypoxia treatment Downregulated H19 and upregulated CYP1B1 were observed in MI patients. 33389498 145 Rat H19 lncRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia treatment upregulated 32319634 146 Rat H19 lncRNA H2O2 myocardial ischemic preconditioning (IP) H9c2 cells H2O2 treatment H19 overexpression enhanced the protective role of H2 O2 -PC in cardiomyocytes. 31975412 147 Rat H19 lncRNA chronic constriction injury (CCI) neuropathic pain (NP) Schwann cells chronic constriction injury (CCI) induce Silencing H19 inhibited NP by suppressing CDK5/p35 and p-CREB phosphorylation via the miR-196a-5p/CDK5 axis. 32903807 148 Rat H19 lncRNA "2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)" ovary development and functions female offspring rats (F1) ovary the pregnant rats were treated with TCDD (100?ng/kg/day or 500?ng/kg/day) or only vehicle and corn oil on the day 8-14 of gestation through the gavage with a stainless-steel feeding needle. The vaginal opening time and estrous cycle of female offspring rats (F1) were monitored twice a day. downregulated 31063829 149 Rat H19 lncRNA metformin (Met) polycystic ovarian syndrome (PCOS) ovary tissues Metformin (Met) treatment downregulated 30989649 150 Rat H19 lncRNA estrogen (ES) postmenopausal osteoporosis (PMOP) bone tissues estrogen treatment upregulated 33577975 151 Rat H19 lncRNA IL-1¦Â pulmonary arterial hypertension (PAH) pulmonary arterial smooth muscle cells (PASMCs) IL-1¦Â treatment upregulated 30547791 152 Rat H19 lncRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) serum; lungs tissues monocrotaline (MCT) treatment H19 was highly expressed in the serum and lungs of MCT-induced models. 30547791 153 Rat H19 lncRNA platelet derived growth factor-BB (PDGF-BB) pulmonary arterial hypertension (PAH) pulmonary arterial smooth muscle cells (PASMCs) platelet-derived growth factor (PDGF)-BB treatment upregulated 30547791 154 Rat H19 lncRNA 3-methyladenine (3-MA) repair of epidermal growth factor (EGF) IEC-6 cells 3-methyladenine (3-MA) treatment downregulated 32301281 155 Rat H19 lncRNA rapamycin repair of epidermal growth factor (EGF) IEC-6 cells Rapamycin treatment upregulated 32301281 156 Rat H19 lncRNA lipopolysaccharide (LPS) sepsis-induced myocardial injury H9c2 cells lipopolysaccharide (LPS) treatment "H19 and SORBS2 were downregulated in H9C2 cells following LPS treatment, while miR-93-5p was upregulated." 32996061 157 Rat H19 lncRNA lipopolysaccharide (LPS) sepsis-induced myocardial injury H9C2 cells lipopolysaccharide (LPS) treatment H19 attenuated the development of sepsis-induced myocardial injury in vitro via modulation of the miR-93-5p/SORBS2 axis. 32996061 158 Rat H19 lncRNA lipopolysaccharide (LPS) spinal cord injury (SCI) primary spinal neurons lipopolysaccharide (LPS) treatment SCI resulted in lncRNA H19 higher expression and miR-370-3p lower expression. 33708438 159 Rat H19 lncRNA metformin and sitagliptin polycystic ovarian syndrome (PCOS) primary ovarian granulosa cells?culture metformin (DMBG) and sitagliptin (TECOS) treatment co-treatment with TECOS and DMBG induced H19 expression via suppressing the PI3K/AKT-DNMT1 pathway. 31405334 160 Rat HCG18 lncRNA high glucose (HG) diabetic peripheral neuropathy (DPN) macrophage high glucose (HG) treatment LncRNA HCG18 was highly expressed in DPN model and HG-induced macrophages. 32996080 161 Rat HIF1A-AS2 lncRNA hypoxia ischemic stroke (IS) HUVECs pMCAO treatment upregulated in infraction areas 28985553 162 Rat HOTAIR lncRNA sepsis acute kidney injury (AKI) ?kidney tissues cecal ligation puncture induced sepsis treatment lncRNA HOTAIR mimics could remarkably improve the renal function of sepsis rats 31081107 163 Rat HOTAIR lncRNA hypoxia acute myocardial infarction (AMI) neonatal rat cardiomyocytes hypoxia treatment downregulated 29258067 164 Rat HOTAIR lncRNA hypoxia acute myocardial infarction (AMI) H9C2 cells hypoxia induce upregulated 30468490 165 Rat HOTAIR lncRNA bisphenol-A (BPA) and diethylstilbestrol (DES) breast cancer mammary glands of rat BPA and DES treatment upregulated 24533974 166 Rat HOTAIR lncRNA exenatide (EXA) cirrhotic cardiomyopathy thioacetamide (TAA)-treated rats cardiac tissue exenatide (EXA) treatment upregulated 31100415 167 Rat HOTAIR lncRNA thioacetamide (TAA) cirrhotic cardiomyopathy cardiac tissue thioacetamide (TAA) treatment downregulated 31100415 168 Rat HOTAIR lncRNA high glucose (HG) diabetic cardiomyopathy (DCM) H9c2 cells ?high glucose (HG) induce HOTAIR protected against DCM via activation of the SIRT1 expression by sponging miR-34a. 30216438 169 Rat HOTAIR lncRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) heart tissues streptozotocin (STZ) treatment HOTAIR was downregulated in the diabetic hearts 30216438 170 Rat HOTAIR lncRNA lipopolysaccharide (LPS) rheumatoid arthritis (RA) chondrocytes obtained from SD rats lipopolysaccharide (LPS) treatment downregulated 28732288 171 Rat HOTAIR lncRNA H2O2 ischemia/reperfusion (I/R) injury H9c2 cells H2O2 treatment HOTAIR was significantly downregulated in H9c2 cells in response to oxidative stimuli. 30239560 172 Rat HOTAIR lncRNA sulfasalazine multiple sclerosis (MS) OLN-93 cells sulfasalazine (SF) treatment SF downregulated lncRNA HOTAIR but upregulated miR-136-5p 29944870 173 Rat HOTAIR lncRNA hypoxia myocardial infarction (MI) rat heart tissues permanent ligation of the left anterior descending (LAD) coronary artery induce downregulated 30607799 174 Rat HOTAIR lncRNA H2O2 myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells H2O2 treatment HOTAIR aggravates myocardial IR by competitively binding SRSF1 with microRNA-126. 32964995 175 Rat HOTAIR lncRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) treatment upregulated 32256945 176 Rat HOTAIR lncRNA matrine oxidative stress H9c2 cells matrine treatment Matrine modulated H2O2-induced myocardial oxidative stress repair through HOTAIR/miR-106b-5p axis via AKT and STAT3 signaling pathway. 32395744 177 Rat HOTAIR lncRNA dehydro-isoandrosterone polycystic ovarian syndrome (PCOS) ovarian tissues and granulosa cells dehydro-isoandrosterone treatment LncRNA HOTAIR up-regulates the expression of IGF1 and aggravates the endocrine disorders and granulosa cell apoptosis through competitive binding to miR-130a in rat models of PCOS. 31733099 178 Rat HOTAIR lncRNA dehydro-isoandrosterone polycystic ovarian syndrome (PCOS) ovarian tissues dehydro-isoandrosterone treatment upregulated 31733099 179 Rat HOTAIR lncRNA paeonol (PAE) renal interstitial fibrosis (RIF) renal tissues or NRK-49F cells paeonol (PAE) treatment PAE was found to decrease HOTAIR and Notch1 expression but to increase the miR-124 expression in RIF rats. 30714138 180 Rat HOTAIR lncRNA sevoflurane (SEV) sevoflurane anesthesia-mediated cognitive dysfunction hippocampus sevoflurane treatment upregulated 29352445 181 Rat HOTTIP lncRNA streptozocin (STZ) diabetic retinopathy (DR) retina tissues streptozocin (STZ) treatment upregulated 29863235 182 Rat HOXA-AS2 lncRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissues streptozotocin (STZ) treatment HOXA-AS2 was downregulated in STZ-induced DN rats 32432759 183 Rat HOXB-AS3 lncRNA doxorubicin (DOX) cardiotoxicity H9c2 cells Doxorubicin (DOX) treatment Relative level of HOXB-AS3 was upregulated in DOX-treated cardiomyocytes. Silence of HOXB-AS3 in cardiomyocytes undergoing DOX treatment markedly elevated their proliferative ability. 32010313 184 Rat HOXB-AS3 lncRNA doxorubicin (DOX) doxorubicin (DOX)-induced cardiotoxicity H9c2 cells doxorubicin (DOX) treatment Relative level of HOXB-AS3 was upregulated in DOX-treated cardiomyocytes. 32010313 185 Rat HULC lncRNA hypoxia/reoxygenation (H/R) acute myocardial infarction (AMI) H9c2 cells hypoxia/reoxygenation (H/R) treatment downregulated 32674625 186 Rat HULC lncRNA dimethylnitrosamine (DMN) liver cirrhosis liver tissues dimethylnitrosamine (DMN) treatment upregulated 31933850 187 Rat IFNG-AS1 lncRNA vildagliptin (Vilda) ulcerative colitis (UC) colon tissues Vildagliptin (Vilda) treatment "Vilda hsa markedly inhibited the expression of lncRNA IFNG-AS1 and miR-146a, as well as PI3K/Akt/NF¦ÊB pathway" 33434756 188 Rat ILF3-AS1 lncRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia treatment ILF3-AS1 was downregulated by hypoxia. 32196615 189 Rat JHDM1D-AS1 lncRNA H2O2 periodontal ligament repair rat periodontal ligament stem cells (PDLSCs) H2O2 treatment downregulated 31276733 190 Rat KCNA2-AS lncRNA varicella zoster virus (VZV) postherpetic neuralgia (PHN) spinal cord tissue Varicella zoster virus (VZV) treatment KCNA2-AS was highly expressed in the spinal cord tissue of PHN model rats 33225882 191 Rat KCNQ1OT1 lncRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia treatment "Kcnq1ot1 sponged miR-466k and miR-466i-5p to up-regulate Tead1, thus triggering cardiomyocyte injury in the process of AMI." 32422306 192 Rat KCNQ1OT1 lncRNA high glucose (HG) diabetic corneal endothelial keratopathy rat corneal endothelial cells high glucose treatment upregulated 31693400 193 Rat KCNQ1OT1 lncRNA streptozocin (STZ) diabetic corneal endothelial keratopathy corneal endothelial cells streptozotocin (STZ) treatment upregulated 31693400 194 Rat KCNQ1OT1 lncRNA ketamine ketamine-induced neurotoxicity neurons of the hippocampus; PC-12 cells ketamine treatment LncRNA KCNQ1OT1 Sponges miR-206 to Ameliorate Neural Injury Induced by Anesthesia via Up-Regulating BDNF. 33204065 195 Rat KCNQ1OT1 lncRNA lipopolysaccharide (LPS) myocardial injury H9c2 cells lipopolysaccharide (LPS) treatment downregulated of KCNQ1OT1 advances cardiac injury through regulating miR-192-5p/XIAP axis during sepsis. 32102564 196 Rat L20992 lncRNA lead (Pb) lead-induced neurotoxicity PC12 cells lead treatment lncRNAL20992 was significantly upregulated in a lead-induced neuronal-injury cell model. 29029323 197 Rat LEF1-AS1 lncRNA lipopolysaccharide (LPS) spinal cord injury (SCI) primary microglial cells lipopolysaccharide (LPS) treatment "We revealed that LncRNA LEF1-AS1 was distinctly upregulated, whereas miR-222-5p was significantly downregulated in LPS-treated SCI and microglial cells." 33407665 198 Rat LEGLTBC lncRNA high glucose (HG) and palmitate (HG/PA) type 2 diabetes mellitus (T2DM) INS-1 cells high glucose and palmitate (HG/PA) treatment downregulated 31737170 199 Rat LET lncRNA hypoxia ischemic heart disease (IHD) H9c2 cells hypoxia treatment downregulated 31222827 200 Rat LET lncRNA hypoxia ischemic heart disease (IHD) H9c2 cells hypoxia induce The expression of lncRNA-LET was repressed by hypoxia. Overexpression of lncRNA-LET attenuated hypoxia-induced injury in H9c2 cells. 31222827 201 Rat Lin28 lncRNA "2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)" colorectal cancer (CRC) rat tumors; colonic mucosa tissues "2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) treatment" the let-7/c-Myc/Lin28 axis is dysregulated in heterocyclic amine-induced colon carcinogenesis 22641368 202 Rat LINC00261 lncRNA hypoxia/reoxygenation (H/R) ischemia/reperfusion (I/R)-mediated acute myocardial infarction (AMI) H9c2 cells hypoxia/reoxygenation (H/R) treatment The expression of LINC00261 was significantly downregulated in H9C2 cells. 32558131 203 Rat LINC00339 lncRNA doxorubicin (DOX) doxorubicin (DOX)-induced cardiotoxicity primary cultured myocardial cells (PC); H9c2 cells doxorubicin (DOX) treatment Primary cultured myocardial cell (PC) and H9C2 cell line were treated with different concentrations of DOX and the expression of LINC00339 were markedly upregulated. 30170730 204 Rat LINC00472 lncRNA lipopolysaccharide (LPS) sepsis-induced acute hepatic injury liver tissues Lipopolysaccharide (LPS) treatment upregulated 33129786 205 Rat LINC00707 lncRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC-12 cells lipopolysaccharide (LPS) treatment LINC00707 alleviates LPS-induced inflammation and apoptosis in PC-12 cells by targeting miR-30a-5p/Neurod 1 31272297 206 Rat LINC00961 lncRNA hypoxia myocardial infarction (MI) cardiomyocytes H9c2 hypoxia induce upregulated 30887575 207 Rat LINC01614 lncRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2cells hypoxia/reoxygenation (H/R) treatment upregulated 32231469 208 Rat LNC_000343 lncRNA iohexol contrast-induced acute kidney injury (CIAKI) Renal tissue "Animals were dehydrated for 48 h and then underwent furosemide (10 mL/kg; Harvest Pharmaceutical, Shanghai, China) injection 30 min before administration of iohexol (15 mL/kg, group CI-AKI; iodine, 350 mg/mL; GE Healthcare, Shanghai, China) or 0.9% normal saline (15 mL/kg, control group)." lncRNA LNC_000343 was downregulated in Contrast-induced acute kidney injury (CI-AKI). 31234008 209 Rat lnc000908 lncRNA isoproterenol cardiac fibrosis heart tissues isoproterenol treatment upregulated 31297954 210 Rat lncRNA00654 lncRNA pentoxifylline (PTX) cardiac injury heart sissues Pentoxifylline (PTX) treatment Pentoxifylline (PTX) treatment produced a dose-dependent decrease in lncRNA-00654 expressions 31972363 211 Rat lncRNA5657 lncRNA lipopolysaccharide (LPS) sepsis-induced lung injury NR8383 cells lipopolysaccharide (LPS) treatment upregulated 32866783 212 Rat LOC102546452 lncRNA lipopolysaccharide (LPS) hepatocarcinogenesis WB-F344 cells lipopolysaccharide (LPS) treatment upregulated 31065105 213 Rat LOC102547847 lncRNA lipopolysaccharide (LPS) hepatocarcinogenesis WB-F344 cells lipopolysaccharide (LPS) treatment upregulated 31065105 214 Rat LOC102549714 lncRNA silica silicosis lung tissues silica treatment upregulated 32028236 215 Rat LOC102549714 lncRNA TGF-¦Â1 silicosis rat lung fibroblasts (FBs) TGF-¦Â1 treatment upregulated 32028236 216 Rat LOC102549726 lncRNA nickel steroidogenesis disturbance Leydig cells NiSO4 induce dysregulated 31734292 217 Rat LOC102549726 lncRNA NiSO4 steroidogenesis disturbance rat Leydig cells NiSO4 treatment upregulated 31734292 218 Rat LOC102550137 lncRNA silica silicosis lung tissues silica treatment upregulated 32028236 219 Rat LOC102550137 lncRNA TGF-¦Â1 silicosis rat lung fibroblasts (FBs) TGF-¦Â1 treatment upregulated 32028236 220 Rat LOC102551149 lncRNA platelet-derived growth factor (PDGF) liver fibrosis hepatic stellate cells (HSCs) platelet-derived growth factor (PDGF) treatment downregulated 32306379 221 Rat LOC102553339 lncRNA lipopolysaccharide (LPS) hepatocarcinogenesis WB-F344 cells lipopolysaccharide (LPS) treatment upregulated 31065105 222 Rat LOC103690121 lncRNA high glucose (HG) type 1 diabetes mellitus (T1DM) rat hippocampal neurons (RN-h cells) high glucose treatment upregulated 30851305 223 Rat LOC103690121 lncRNA streptozocin (STZ) type 1 diabetes mellitus (T1DM) hippocampal tissues streptozotocin (STZ) treatment upregulated 30851305 224 Rat LOC103691197 lncRNA lipopolysaccharide (LPS) hepatocarcinogenesis WB-F344 cells lipopolysaccharide (LPS) treatment upregulated 31065105 225 Rat LOC103691336 lncRNA MgSO4 osteogenesis rat primary bone marrow stromal cells MgSO4 treatment upregulated 31081160 226 Rat LOC103691771 lncRNA silica silicosis lung tissues silica treatment upregulated 32028236 227 Rat LOC103691771 lncRNA TGF-¦Â1 silicosis rat lung fibroblasts (FBs) TGF-¦Â1 treatment upregulated 32028236 228 Rat LOC103692016 lncRNA silica silicosis lung tissues silica treatment downregulated 32028236 229 Rat LOC103692016 lncRNA TGF-¦Â1 silicosis rat lung fibroblasts (FBs) TGF-¦Â1 treatment downregulated 32028236 230 Rat LOC103692656 lncRNA lipopolysaccharide (LPS) hepatocarcinogenesis WB-F344 cells lipopolysaccharide (LPS) treatment upregulated 31065105 231 Rat LOC103693125 lncRNA silica silicosis lung tissues silica treatment downregulated 32028236 232 Rat LOC103693125 lncRNA TGF-¦Â1 silicosis rat lung fibroblasts (FBs) TGF-¦Â1 treatment downregulated 32028236 233 Rat Lrrc75a-as1 lncRNA inorganic phosphate (Pi) vascular calcification (VC) rat vascular smooth muscle cells (VSMCs) inorganic phosphate treatment downregulated 30971745 234 Rat MAGI1-IT1 lncRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment downregulated 31222747 235 Rat MAGI1-IT1 lncRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment MAGI1-IT1 functioned as a negative regulator in CH through inactivating Wnt/beta-catenin pathway via targeting miR-302e/DKK1 axis 31222747 236 Rat MALAT1 lncRNA lipopolysaccharide (LPS) acute kidney injury (AKI) kidney tissues; NRK-52E cells lipopolysaccharide (LPS) treatment upregulated 29115409 237 Rat MALAT1 lncRNA lipopolysaccharide (LPS) acute kidney injury (AKI) NRK-52E cells lipopolysaccharide (LPS) treatment upregulated 29115409 238 Rat MALAT1 lncRNA "5(S), 6(R),7-trihydroxyheptanoic acid methyl ester (BML-111)" acute lung injury (ALI) lung tissues BML-111 treatment upregulated 29704485 239 Rat MALAT1 lncRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues lipopolysaccharide (LPS) treatment MALAT1 was upregulated and mir-146a was downregulated in lps-induced ALI rat model. 29649906 240 Rat MALAT1 lncRNA hyperbaric oxygen (HBO) acute myocardial infarction (AMI) Rat cardiac myocytes Hyperbaric oxygen (HBO) treatment HBO significantly increased MALAT1 expression in cardiac myocytes. 32939962 241 Rat MALAT1 lncRNA hypoxia acute myocardial infarction (AMI) heart tissues ligation of the left anterior descending coronary artery upregulated 32010261 242 Rat MALAT1 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) acute myocardial infarction (AMI) H9c2 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 31669130 243 Rat MALAT1 lncRNA caerulein (Cae) acute pancreatitis (AP) "AR42J, a rat pancreatic acinar cell line" caerulein (Cae) treatment upregulated 31518341 244 Rat MALAT1 lncRNA lipopolysaccharide (LPS) acute respiratory distress syndrome (ARDS) lung tissues lipopolysaccharide (LPS) treatment upregulated 33407436 245 Rat MALAT1 lncRNA lipopolysaccharide (LPS) acute spinal cord injury (ASCI) primary microglia lipopolysaccharide (LPS) treatment "Upon treatment with LPS, MALAT1 expression dramatically increased in the microglia in vitro." 29631367 246 Rat MALAT1 lncRNA amyloid-¦Â (A¦Â) 1-42 Alzheimer's disease (AD) nerve growth factor (NGF) stimulated PC 12 cells and primary cerebral cortex neurons of rat embryo amyloid ¦Â1-42?(A¦Â) treatment downregulated 31345147 247 Rat MALAT1 lncRNA amyloid-¦Â (A¦Â) 25-35 Alzheimer's disease (AD) PC12; C6 cells amyloid-¦Â (A¦Â) 25-35 treatment MALAT1 could promote neuronal recovery following AD through the miR-30b/CNR1 network and the PI3K/AKT signaling activation. 32976819 248 Rat MALAT1 lncRNA fluid-percussion injury (FPI) brain edema astrocyte fluid percussion injury (FPI) induce downregulated 31218751 249 Rat MALAT1 lncRNA cadmium (Cd) cadmium-induced toxicity rats lung cadmium (Cd) treatment upregulated in the lung 30090506 250 Rat MALAT1 lncRNA lipopolysaccharide (LPS) cell differentiation differentiated BM-MSCs lipopolysaccharide (LPS) treatment "In hepatocytes differentiated from BM-MSCs, miR-217 was downregulated and lncRNA MALAT1 was upregulated. RIP analysis showed MALAT1 was physically associated with miR-217 and might function in the regulation of ZEB-1, further enhancing the expression of TERT so as to augment telomerase activity." 30658864 251 Rat MALAT1 lncRNA aerobic exercise chronic heart failure (CHF) myocardial tissues aerobic exercise training (AET) treatment upregulated 33708967 252 Rat MALAT1 lncRNA streptozocin (STZ) diabetes-related microvascular complications diabetic rats retinal endothelial cell STZ treatment upregulated 25356875 253 Rat MALAT1 lncRNA streptozocin (STZ) diabetic gastroparesis (DGP) stomach streptozocin (STZ) treatment MALAT1 was upregulated in rat model of DGP 29317209 254 Rat MALAT1 lncRNA streptozocin (STZ) diabetic nephropathy (DN) rats renal tubular epithelial cells streptozotocin treatment upregulated 27964927 255 Rat MALAT1 lncRNA angiotensin II (Ang II) hypertension rat vascular tissues angiotensin II (Ang II) treatment upregulated 31343412 256 Rat MALAT1 lncRNA hypoxia hypoxia-induced injury PC12 cells hypoxia treatment upregulated 29360503 257 Rat MALAT1 lncRNA H2O2 myocardial infarction (MI) H9C2 cells H2O2 treatment upregulated 30841417 258 Rat MALAT1 lncRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia induce Hypoxia significantly enhanced the expression of Malat1. Knockdown of Malat1 aggravated hypoxia-induced H9c2 cell injury. 30843674 259 Rat MALAT1 lncRNA isoproterenol myocardial infarction (MI) heart tissues isoproterenol (ISO) treatment LncRNA MALAT1 was upregulated in the myocardial infarction areas. 30536615 260 Rat MALAT1 lncRNA isoproterenol myocardial infarction (MI) rat H9C2 cells isoproterenol (ISO) treatment lncRNA MALAT1 protected cardiomyocytes from ISO-induced apoptosis by sponging miR-558 thus promoting ULK1-dependent autophagy. 30536615 261 Rat MALAT1 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cardiomyocytes oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 31823095 262 Rat MALAT1 lncRNA lipopolysaccharide (LPS) myocarditis H9c2 cells lipopolysaccharide (LPS) treatment downregulated 31027517 263 Rat MALAT1 lncRNA myricetin myocarditis LPS-treated H9c2 cells myricetin treatment upregulated 31027517 264 Rat MALAT1 lncRNA brachial plexus avulsion neuropathic pain (NP) spinal cords brachial plexus avulsion induce downregulated 31114309 265 Rat MALAT1 lncRNA chronic constriction injury (CCI) neuropathic pain (NP) L4©\L6 dorsal spinal cord of rats chronic constriction injury (CCI) induce upregulated 30740678 266 Rat MALAT1 lncRNA sevoflurane (SEV) neurotoxicity rat hippocampal tissues Sevoflurane exposure treatment "Suppression of MALAT1 can reduce the apoptosis of hippocampal neurons induced by sevoflurane anesthesia, improve the capability of spatial learning, and memory function and alleviate the loss of hippocampal nerve cells in developing rats" 31190336 267 Rat MALAT1 lncRNA lipopolysaccharide (LPS) osteoarthritis (OA) rat chondrocytes lipopolysaccharide (LPS) treatment MALAT1 was upregulated in chondrocytes induced by LPS. 31472145 268 Rat MALAT1 lncRNA lipopolysaccharide (LPS) osteoarthritis (OA) Isolated rat chondrocytes lipopolysaccharide (LPS) treatment "In OA patients and OA cell model, the expression of MALAT1 and PI3K was clearly reduced. Following with MALAT1 silencing, the generation of Cyclooxygenase-2 (COX-2), Interleukin-6 (IL-6) and Matrix metallopeptidase-13 (MMP-13) were promoted, while the level of type II collagen (COL2) was inhibited. Moreover, MALAT1 silencing caused a significant reduction in the proliferative rate of LPS-treated chondrocytes through inducing apoptosis." 31472145 269 Rat MALAT1 lncRNA green tea polyphenols (GTP) oxidative stress PC12 cells PC12 cells were preincubated with GTP prior to H2O2 stimulation upregulated 31456460 270 Rat MALAT1 lncRNA uterine perfusion pressure (RUPP) pregnancy-induced hypertension (PIH) aortic endothelial cells (ECs) uterine perfusion pressure (RUPP) treatment upregulated 32351607 271 Rat MALAT1 lncRNA resveratrol pulmonary embolism pulmonary embolism (PE) induced heart tissues resveratrol (Res) treatment downregulated 31573048 272 Rat MALAT1 lncRNA high glucose (HG) pyroptosis H9c2 cells high glucose (HG) treatment "MALAT1 mRNA expression levels were significantly increased, whereas miR-141-3p expression levels were significantly decreased in HG-treated H9C2 cells compared with the NG group." 33576445 273 Rat MALAT1 lncRNA sinapic acid (SA) pyroptosis macrophages sinapic acid (SA) treatment downregulated 29095793 274 Rat MALAT1 lncRNA ginkgo biloba extract (GBE) renal injury methotrexate (MTX)-induce rat renal tissues Ginkgo biloba extract (GB) treatment downregulated 31684190 275 Rat MALAT1 lncRNA methotrexate (MTX) renal injury renal tissues Methotrexate (MTX) treatment upregulated 31684190 276 Rat MALAT1 lncRNA cecal ligation and puncture (CLP) sepsis rats cecal ligation and puncture (CLP) treatment upregulated 29227823 277 Rat MALAT-1 lncRNA IL-1¦Â articular cartilage inflammation primary articular chondrocytes culture IL-1¦Â?treatmrnt "In response to IL-1¦Â induction, articular chondrocytes showed reduced MALAT-1 expression; moreover, obvious cartilage injury was observed with decreased chondrocyte viability and Col II expression and elevated chondrocyte apoptosis, MMP-13 expression, and p-JNK expression." 31111559 278 Rat MALAT1EZH2 lncRNA cecal ligation and puncture (CLP) sepsis Sprague-Dawley (SD) rats cecal ligation and puncture (CLP) treatment upregulated 28831768 279 Rat MALAT1EZH2 lncRNA lipopolysaccharide (LPS) sepsis cardiac microvascular endothelial cells (CMVECs) lipopolysaccharide (LPS) treatment upregulated 28831769 280 Rat MANTIS lncRNA monocrotaline (MCT) idiopathic pulmonary arterial hypertension human umbilical vein endothelial cells monocrotaline treatment downregulated 28351900 281 Rat MEG3 lncRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia treatment upregulated 28731278 282 Rat MEG3 lncRNA hypoxia acute myocardial infarction (AMI) rat cardiomyocyte-drived H9c2 cells hypoxia upregulated 28731278 283 Rat MEG3 lncRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia induce "The expression levels of MEG3 and TRPV4 were significantly increased, whereas miR-325-3p expression levels were significantly decreased in hypoxic H9c2 cells compared with normoxic H9c2 cells." 33179099 284 Rat MEG3 lncRNA oxygen glucose deprivation (OGD) apoptosis H9c2 cells oxygen and glucose deprivation (OGD) induce treatment upregulated 31184214 285 Rat MEG3 lncRNA salvianolic acid B (Sal B) apoptosis hypoxia-induced H9c2 cells ?Salvianolic acid B (Sal-B) treatment downregulated 31184214 286 Rat MEG3 lncRNA high glucose (HG) cardiomyocytes injury Primary cultures of ventricular myocytes high glucose (HG) treatment The downregulated of MEG3 could attenuate cardiomyocytes injury and apoptosis induced by HG. 31539151 287 Rat MEG3 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral infarction (CI) rat brain microvascular endothelial cells (RBMVECs) oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 28634073 288 Rat MEG3 lncRNA hypoxia cerebral ischemia/reperfusion (I/R) injury brain tissues middle cerebral artery occlusion (MCAO) induce upregulated 30841460 289 Rat MEG3 lncRNA N-acetyl-L-cysteine (NAC) cirrhotic neuropathy thiacetamide (TAA)-treated rats liver tissues and sciatic nerve N-acetylcysteine (NAC) treatment downregulated 31751619 290 Rat MEG3 lncRNA thioacetamide (TAA) cirrhotic neuropathy liver tissues and sciatic nerve thiacetamide (TAA) treatment upregulated 31751619 291 Rat MEG3 lncRNA streptozocin (STZ) diabetes-related cognitive impairments PC12 cells streptozotocin (STZ) treatment "Here, it was observed that MEG3 was significantly downregulated in STZ (streptozotocin)-induced diabetic rats" 33843209 292 Rat MEG3 lncRNA streptozocin (STZ) diabetic nephropathy (DN) rat kidney tissues streptozotocin treatment downregulated 31799068 293 Rat MEG3 lncRNA high glucose (HG) diabetic retinopathy (DR) microvascular endothelial cells high glucose (HG) treatment DNMT1-mediated lncRNA MEG3 methylation accelerates endothelial-mesenchymal transition in diabetic retinopathy through the PI3K/Akt/mTOR signaling pathway 33284093 294 Rat MEG3 lncRNA streptozocin (STZ) diabetic retinopathy (DR) retinal lesions streptozotocin treatment DNMT1-mediated lncRNA MEG3 methylation accelerates endothelial-mesenchymal transition in diabetic retinopathy through the PI3K/Akt/mTOR signaling pathway 33284093 295 Rat MEG3 lncRNA hypoxia hypoxia-induced injury pheochromocytoma-12 (PC12) cell hypoxia induce upregulated 31392726 296 Rat MEG3 lncRNA hypoxia hypoxia-induced injury PC12 cells hypoxia treatment MEG3 silencing suppresses hypoxia-induced PC12 cell injury by inhibiting TIMP2 promoter methylation. 31392726 297 Rat MEG3 lncRNA hyperoxia hypoxic/ischemic brain damage (HIBD) PC12 cells hypoxia treatment Silencing MEG3 protects PC12 cells from hypoxic injury by targeting miR-21. 32050796 298 Rat MEG3 lncRNA platelet-derived growth factor (PDGF) intimal hyperplasia (IH) vascular smooth muscle cell (VSMCs) Platelet derived growth factor (PDGF)-BB treatment PDGF-BB decreasedthe expression of MEG3 30156956 299 Rat MEG3 lncRNA hypoxia ischemic stroke (IS) mouse brain tissues middle cerebral artery occlusion (MCAO) upregulated 31794744 300 Rat MEG3 lncRNA platelet derived growth factor-BB (PDGF-BB) ischemia/reperfusion (I/R) injury vascular smooth muscle cell (VSMCs) Platelet derived growth factor (PDGF)-BB treatment downregulated 30156956 301 Rat MEG3 lncRNA hypoxia ischemic stroke (IS) Sprague¨CDawley rats brain tissues middle cerebral artery occlusion (MCAO) treatment downregulated in brain tissues 27900677 302 Rat MEG3 lncRNA thioacetamide (TAA) liver cirrhosis liver tissues thiacetamide (TAA) treatment upregulated 31751619 303 Rat MEG3 lncRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) rat H9C2 cells hypoxia induce downregulated of MEG3 protects myocardial cells against I/R-induced apoptosis through miR-7-5p/PARP1 pathway 31366567 304 Rat MEG3 lncRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) The myocardial A10 cell lines hypoxia induce upregulated 31389596 305 Rat MEG3 lncRNA IL-1¦Â osteoarthritis (OA) rat chondrocytes IL-1¦Â treatment downregulated 31253047 306 Rat MEG3 lncRNA nickel oxide nanoparticles (NiO NPs) lung fibrosis lung tissues Nickel oxide nanoparticles (NiO NPs) treatment downregulated 33547861 307 Rat MEG3 lncRNA "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine)" rheumatoid arthritis (RA) synovial tissues and fibroblast-like synoviocytes (FLSs) "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine) treatment" upregulated 30644097 308 Rat MEG3 lncRNA complete freund's adjuvant (CFA) rheumatoid arthritis (RA) synovial tissues and fibroblast-like synoviocytes (FLSs) complete Freund's adjuvant (CFA) treatment downregulated 30644097 309 Rat MEG3 lncRNA lipopolysaccharide (LPS) rheumatoid arthritis (RA) chondrocyte lipopolysaccharide (LPS) treatment MEG3 was downregulated evidently in lipopolysaccharide (LPS)-treated chondrocyte. upregulated MEG3 resulted in an increase the level of Ki67. 31411001 310 Rat MEG3 lncRNA lithium chloride and pilocarpine temporal lobe epilepsy (TLE) hippocampal neuronal lithium chloride and pilocarpine treatment "MEG3 reduced proinflammatory cytokines, oxidative stress, and apoptosis rate of hippocampal neuron and enhanced cell viability through the activation of the PI3K/AKT/mTOR pathway in SREDs and rats with TLE." 33149593 311 Rat MEG3 lncRNA "2,4,6-trinitrobenzene sulfonic acid (TNBS)" ulcerative colitis (UC) colon tissues "2, 4, 6-Trinitrobenzenesulfonic acid solution (TNBS) treatment" downregulated 33394187 312 Rat MHRT lncRNA H2O2 cardiomyocytes against H2O2-Induced Apoptosis cardiac myocytes H2O2 treatment upregulated 26759697 313 Rat Mhrt lncRNA doxorubicin (DOX) doxorubicin (DOX)-induced dysfunction cardiomyocytes doxorubicin (DOX) treatment upregulated 27261628 314 Rat MIAT lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) PC12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 33745924 315 Rat MIAT lncRNA angiotensin II (Ang II) cardiac hypertrophy cardiomyocytes isolated from 1 to 2-day-old Wistar rats angiotensin II (Ang II) treatment upregulated 29157986 316 Rat MIAT lncRNA angiotensin II (Ang II) cardiac hypertrophy cardiomyocytes angiotensin II (Ang II) treatment MIAT was upregulated and miR-93 was downregulated in AngII-treated cardiomyocytes. 29673400 317 Rat MIAT lncRNA isoprenaline cardiac hypertrophy rat primary cardiomyocytes isoprenaline induction upregulated 33013286 318 Rat MIAT lncRNA isoproterenol cardiac hypertrophy Neonatal rat ventricular myocytes (NRVMs) isoproterenol (ISO) treatment upregulated 29786749 319 Rat MIAT lncRNA oxygen glucose deprivation (OGD) cerebral ischemia injury (CII) primary cultured cerebral microvascular endothelial cell (CMEC) oxygen glucose deprivation (OGD) treatment upregulated 31628679 320 Rat MIAT lncRNA oxygen glucose deprivation (OGD) cerebral microvascular endothelial cell (CMEC) injury cerebral microvascular endothelial cell (CMEC) oxygen glucose deprivation (OGD) treatment upregulated 31628679 321 Rat MIAT lncRNA glucose diabetic cardiomyopathy (DCM) neonatal cardiomyocytes of rats treat with high glucose upregulated 28703801 322 Rat MIAT lncRNA high glucose (HG) diabetic retinopathy (DR) rat retinal M¨¹ller cells (rMC-1) cells high glucose upregulated 28246353 323 Rat MIAT lncRNA high glucose (HG) diabetic retinopathy (DR) M¨¹ller cells high glucose treatment upregulated 31344482 324 Rat MIAT lncRNA berberine (BBR) cardiac hypertrophy rat heart tissues berberine (BBR) treatment downregulated 31612504 325 Rat MIAT lncRNA hypoxia hypoxic/ischemic injury striatal tissues hypoxia treatment lncRNA MIAT was downregulated in striatal tissues of neonatal rats in HI group. 30563429 326 Rat MIAT lncRNA low selenium Kashin-Beck Disease (KBD) serum low selenium and/or T-2 toxin treatment "LncRNA MIAT regulated by selenium and T-2 toxin increases NF-¦ÊB-p65 activation, promoting the progress of Kashin-Beck Disease" 33233966 327 Rat MIAT lncRNA T-2 toxin Kashin-Beck Disease (KBD) serum low selenium and/or T-2 toxin treatment "LncRNA MIAT regulated by selenium and T-2 toxin increases NF-¦ÊB-p65 activation, promoting the progress of Kashin-Beck Disease" 33233966 328 Rat MIAT lncRNA electrode cardiac fibrosis atrium tissues of rats electrode stimulation upregulated 32130618 329 Rat MIAT lncRNA catechin myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells catechin treatment Catechin relieved H/R-induced myocardial cell apoptosis through regulating CREB/lncRNA MIAT/Akt/Gsk-3¦Â pathway. 31955523 330 Rat MIAT lncRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells hypoxia induce "targeting MIAT remarkably enhanced H9c2 cell viability, decreased H/R-induced cell apoptosis and LDH leakage and significantly decreased I/R-induced myocardial infarct size, reduced myocardial apoptosis and enhanced the heart function." 30971184 331 Rat MIAT lncRNA hypoxic/ischemic neonatal cerebral palsy striatal tissues hypoxic-ischemic (HI) treatment "MIAT overexpression reduced apoptosis of Neuro2A cells through miR-211/GDNF, which relieved HI injury of neonatal rats." 30563429 332 Rat MIAT lncRNA huo xue tong luo capsule (HXTL capsule) osteogenesis Rat bone marrow mesenchymal stem cells (rMSCs) Huo Xue Tong Luo capsule (HXTL capsule) treatment downregulated 30970282 333 Rat MIAT lncRNA sepsis renal injury ?kidney tissues cecal ligation puncture induced sepsis treatment lincRNA-MIAT increased in the sepsis-induced kidney injury model 31858562 334 Rat MIAT lncRNA high glucose (HG) renal tubules injury tubules high glucose treatment downregulated 26551455 335 Rat Mirt1 lncRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) diabetic rats heart tissues "The rats were fixed in supine position, intubated through right common carotid artery, and connected with a pressure transducer." upregulated 30611788 336 Rat Mirt2 lncRNA hypoxia/reoxygenation (H/R) acute myocardial infarction (AMI) H9c2 cells hypoxia/reoxygenation (H/R) treatment upregulated 33199822 337 Rat Mirt2 lncRNA hypoxia/reoxygenation (H/R) acute myocardial infarction (AMI) H9c2 cells hypoxia reoxygenation (H/R) treatment Mirt2 participated in the regulation of MI through the miR-764/PDK1 axis. 33199822 338 Rat Mirt2 lncRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC12 cell lipopolysaccharide (LPS) treatment ?lncRNA Mirt2 was upregulated in LPS-stimulated PC12 cells. Overexpression of lncRNA Mirt2 protected PC12 cells against LPS-induced injuries. 31309444 339 Rat MRAK134679 lncRNA angiotensin II (Ang II) cardiac fibrosis Sprague-Dawley (SD) rats angiotensin II (Ang II) treatment upregulated 24817929 340 Rat MRAK154943 lncRNA ischemia stroke rat cortical tissues focal ischemia treatment upregulated 24063527 341 Rat MRAK159688 lncRNA ischemia stroke rat cortical tissues focal ischemia treatment upregulated 24063527 342 Rat MRNR026574 lncRNA angiotensin II (Ang II) cardiac fibrosis Sprague-Dawley (SD) rats angiotensin II (Ang II) treatment upregulated 24817929 343 Rat MRuc008hvl lncRNA subarachnoid hemorrhage (SAH) early brain injury (EBI) brain subarachnoid hemorrhage (SAH) treatment upregulated 25777551 344 Rat MSTRG.11559 lncRNA bleomycin (BLM) lung fibrosis lung tissues bleomycin (BLM) treatment upregulated 33193637 345 Rat MSTRG.11560 lncRNA bleomycin (BLM) lung fibrosis lung tissues bleomycin (BLM) treatment upregulated 33193637 346 Rat MSTRG.15160 lncRNA bleomycin (BLM) lung fibrosis lung tissues bleomycin (BLM) treatment upregulated 33193637 347 Rat MSTRG.199 lncRNA bleomycin (BLM) lung fibrosis lung tissues bleomycin (BLM) treatment upregulated 33193637 348 Rat MSTRG.30244 lncRNA bleomycin (BLM) lung fibrosis lung tissues bleomycin (BLM) treatment downregulated 33193637 349 Rat MSTRG.34031.1 lncRNA quercetin oxidative stress PC-12 cells Quercetin treatment downregulated 33343808 350 Rat MSTRG.4076.1 lncRNA quercetin oxidative stress PC-12 cells Quercetin treatment downregulated 33343808 351 Rat MSTRG.48686.2 lncRNA quercetin oxidative stress PC-12 cells Quercetin treatment downregulated 33343808 352 Rat MSTRG.89940.1 lncRNA quercetin oxidative stress PC-12 cells Quercetin treatment upregulated 33343808 353 Rat N1LR lncRNA ischemia/reperfusion (I/R) ischemia/reperfusion (I/R) injury brain tissues ischemia/reperfusion (I/R) treatment upregulated 27844279 354 Rat NEAT1 lncRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia induce upregulated 30950059 355 Rat NEAT1 lncRNA lipopolysaccharide (LPS) acute kidney injury (AKI) rat mesangial cells (RMCs) lipopolysaccharide (LPS) treatment upregulated 29669307 356 Rat NEAT1 lncRNA amyloid-¦Â (A¦Â) 1-42 Alzheimer's disease (AD) PC-12 cells amyloid ¦Â1-42?(A¦Â) treatment upregulated 31014193 357 Rat NEAT1 lncRNA phenylephrine (PE) cardiac hypertrophy primary cardiomyocytes; myocardium phenylephrine (PE) treatment NEAT1 was highly expressed in myocardium of rats with cardiac hypertrophy and PE-induced primary cardiomyocytes 32096186 358 Rat NEAT1 lncRNA hypoxia cardiomyocyte apoptosis H9c2 cardiomyocyte cell line hypoxia induce upregulated 31410172 359 Rat NEAT1 lncRNA arsenic trioxide (ATO) cardiac injury H9c2 cells arsenic trioxide (As2O3) treatment NEAT1 regulated the expression of inflammatory factors to protect cardiomyocytes from As2O3 damage by inhibiting miR-124/NF-kappa B signaling pathway. 32096187 360 Rat NEAT1 lncRNA doxorubicin (DOX) cardiotoxicity H9c2 cells doxorubicin (Dox)?treatment upregulation of miRNA let-7f-2-3p by long noncoding RNA (lncRNA) NEAT1 inhibits exportin-1 (XPO1)-mediated nuclear export of hematopoietic-substrate-1 associated protein X-1 (HAX-1) in Dox-induced cardiotoxicity. 31570982 361 Rat NEAT1 lncRNA gastrodin (GAS) cerebral ischemia/reperfusion (I/R) injury OGD/R-treated rat primary cortical neurons gastrodin (GAS) treatment downregulated 33839999 362 Rat NEAT1 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia/reperfusion (I/R) injury Rat primary cortical neurons oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 33839999 363 Rat NEAT1 lncRNA nimodipine cognitive impairment brain tissues nimodipine treatment Nimodipine can improve CI after SAH in rats through the lncRNA NEAT1/miR-27a/MAPT axis. 32606599 364 Rat NEAT1 lncRNA high glucose (HG) diabetic nephropathy (DN) rat glomerular mesangial cell line (HBZY-1) high glucose (HG) treatment upregulated 32721950 365 Rat NEAT1 lncRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissues streptozocin (STZ) treatment NEAT1 was significantly increased in streptozotocin-induced DN rat models 30549040 366 Rat NEAT1 lncRNA streptozocin (STZ) diabetic nephropathy (DN) rat kidney tissues streptozotocin (STZ) treatment upregulated 30549040 367 Rat NEAT1 lncRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissues streptozocin (STZ) treatment NEAT1 in the kidney was upregulated in the STZ-induced DN rats. 32721950 368 Rat NEAT1 lncRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissues streptozotocin treatment upregulated 30515796 369 Rat NEAT1 lncRNA IL-1¦Â epilepsy CTX-TNA cells IL-1¦Â treatment upregulated 31948324 370 Rat NEAT1 lncRNA ischemia/reperfusion (I/R) ischemia/reperfusion (I/R) injury PC12 cells ischemia/reperfusion (I/R) treatment LncRNA NEAT1 aggravates cerebral I/R injury by suppressing miR-874-3p expression. 32329323 371 Rat NEAT1 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) Rat primary microglial cell culture oxygen-glucose deprivation and reoxygenation (OGD/R) treatment YY1-induced upregulation of NEAT1 contributed to the OGD/R injury and neuroinflammation damage of microglial cells via Wnt/¦Â-catenin signaling pathway 31286366 372 Rat NEAT1 lncRNA H2O2 myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells H2O2 treatment upregulated 31347173 373 Rat NEAT1 lncRNA H2O2 myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells H2O2 treatment NEAT1 contributed to M-I/R injury via the modulation of miR-495-3p and MAPK6. 31347173 374 Rat NEAT1 lncRNA free fatty acids (FFA) nonalcoholic fatty liver disease (NAFLD) BRL3A cell free fatty acid (FFA) treatment upregulated 31957704 375 Rat NEAT1 lncRNA "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)" parkinson's disease (PD) brain tissues "1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) treatment" upregulated 29575151 376 Rat NEAT1 lncRNA hypoxia reperfusion injury rat cardiomyocytes hypoxia treatment downregulated 32826883 377 Rat NEAT1 lncRNA lipopolysaccharide (LPS) sepsis H9c2 cells lipopolysaccharide (LPS) treatment lncRNA NEAT1 accelerated apoptosis and inflammation in LPS-stimulated H9c2 cells via sponging miR-590-3p. 32855700 378 Rat NEAT1 lncRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC-12 cells lipopolysaccharides (LPS) treatment High NEAT1 levels can increase LPS-induced injury in PC-12 cells through the miR-29a/BCL2L11 pathway. 32776916 379 Rat NKILA lncRNA hypoxia/reoxygenation (H/R) myocardial ischaemic injury H9C2 cells hypoxia/reoxygenation (H/R) treatment NKILA enhanced the expression of myocardin via inhibiting the NF-¦ÊB signalling pathway and preventing cell apoptosis and the inflammatory response of cardiomyocytes. 31838061 380 Rat NKILA lncRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 rat myoblasts hypoxia induce downregulated 31838061 381 Rat NONRATT002335 lncRNA bile duct ligation (BDL) jaundice Sprague-Dawley rats the common bile duct was located and ligated using 4-0 silk at two points anterior to the pancreas and posterior to the hilum of the liver upregulated 29285317 382 Rat NONRATT004911.2 lncRNA liraglutide type 2 diabetes mellitus (T2DM) pancreases Liraglutide treatment downregulated 32238798 383 Rat NONRATT005195.2 lncRNA adriamycin (ADR) chronic glomerulonephritis (CGN) glomerular tissues adriamycin (ADR) treatment downregulated 30458286 384 Rat NONRATT008453.2 lncRNA dibutyl phthalate (DBP) hypospadias genital tubercle (GT) dibutyl phthalate (DBP) treatment "Furthermore, out of the 103 putative autophagy©\related lncRNAs, NONRATT008453.2 was the highest expressed lncRNA in the DBP©\treated group compared with the controls." 33452730 385 Rat NONRATT009003.2 lncRNA adriamycin (ADR) chronic glomerulonephritis (CGN) glomerular tissues adriamycin (ADR) treatment downregulated 30458286 386 Rat NONRATT009208.2 lncRNA adriamycin (ADR) chronic glomerulonephritis (CGN) glomerular tissues adriamycin (ADR) treatment downregulated 30458286 387 Rat NONRATT009275.2 lncRNA adriamycin (ADR) chronic glomerulonephritis (CGN) glomerular tissues adriamycin (ADR) treatment upregulated 30458286 388 Rat NONRATT009530.2 lncRNA adriamycin (ADR) chronic glomerulonephritis (CGN) glomerular tissues adriamycin (ADR) treatment upregulated 30458286 389 Rat NONRATT010788.2 lncRNA lithium chloride and pilocarpine status epilepticus (SE) hippocampus lithium/pilocarpine treatment 31738000 390 Rat NONRATT015587.2 lncRNA metformin (Met) pulmonary arterial hypertension (PAH) PAH rat pulmonary arterial tissues metformin treatment downregulated 31060005 391 Rat NONRATT015587.2 lncRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) rat pulmonary arterial tissues monocrotaline treatment upregulated 31060005 392 Rat NONRATT015614.2 lncRNA liraglutide type 2 diabetes mellitus (T2DM) pancreases Liraglutide treatment downregulated 32238798 393 Rat NONRATT018085 lncRNA bile duct ligation (BDL) jaundice Sprague-Dawley rats the common bile duct was located and ligated using 4-0 silk at two points anterior to the pancreas and posterior to the hilum of the liver upregulated 29285317 394 Rat NONRATT018630.2 lncRNA liraglutide type 2 diabetes mellitus (T2DM) pancreases Liraglutide treatment downregulated 32238798 395 Rat NONRATT021972 lncRNA high glucose and free fatty acids (HG-FFA) diabetic cardiac autonomic neuropathy (DCAN) sympathetic neuronal-like PC12 cells high glucose (HG) and high FFAs (HF) treatment upregulated 27519467 396 Rat NONRATT021972 lncRNA streptozocin (STZ) type 2 diabetes mellitus (T2DM) rats DRG intraperitoneal injection of STZ with 30 mg/kg treatment upregulated in 26742527 397 Rat NONRATT023402.2 lncRNA levodopa levodopa-induced dyskinesia (LID) PC1 2cells Levodopa treatment downregulated 31929116 398 Rat NONRATT024782.2 lncRNA liraglutide type 2 diabetes mellitus (T2DM) pancreases Liraglutide treatment upregulated 32238798 399 Rat NONRATT025388 lncRNA bile duct ligation (BDL) jaundice Sprague-Dawley rats the common bile duct was located and ligated using 4-0 silk at two points anterior to the pancreas and posterior to the hilum of the liver downregulated 29285317 400 Rat NONRATT025409 lncRNA bile duct ligation (BDL) jaundice Sprague-Dawley rats the common bile duct was located and ligated using 4-0 silk at two points anterior to the pancreas and posterior to the hilum of the liver downregulated 29285317 401 Rat NONRATT025415 lncRNA bile duct ligation (BDL) jaundice Sprague-Dawley rats the common bile duct was located and ligated using 4-0 silk at two points anterior to the pancreas and posterior to the hilum of the liver downregulated 29285317 402 Rat NONRATT026027.2 lncRNA liraglutide type 2 diabetes mellitus (T2DM) pancreases Liraglutide treatment downregulated 32238798 403 Rat NONRATT026805.2 lncRNA adriamycin (ADR) chronic glomerulonephritis (CGN) glomerular tissues adriamycin (ADR) treatment upregulated 30458286 404 Rat NONRATT029906.2 lncRNA liraglutide type 2 diabetes mellitus (T2DM) pancreases Liraglutide treatment upregulated 32238798 405 Rat NR_002155.1 lncRNA carbon tetrachloride (CCl4) liver fibrosis liver tissues carbon tetrachloride (CCl4) treatment downregulated 29749545 406 Rat NR_024118 lncRNA angiotensin II (Ang II) cardiac fibrosis cardiac angiotensin II (Ang II) treatment downregulated 25979571 407 Rat NR_024118 lncRNA angiotensin II (Ang II) cardiac fibrosis Sprague-Dawley (SD) rats angiotensin II (Ang II) treatment upregulated 24817929 408 Rat NR_024118 lncRNA losartan cardiac fibrosis heart tissues Losartan treatment losartan (AT1 blocker) nearly completely reversed the decrease of lncRNA-NR024118 and partly reversed the decrease of Cdkn1c induced by Ang II in adult rat cardiac fibroblasts 25979571 409 Rat NR_026689 lncRNA NNK lung cancer lung tissues NNK treatment upregulated 26908441 410 Rat NR_027943 lncRNA methamphetamine (METH) neurotoxicity prefrontal cortical neurons Methamphetamine treatment upregulated 28619521 411 Rat NR_031896.1 lncRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment downregulated 30373531 412 Rat NR_038323 lncRNA streptozocin (STZ) diabetic retinopathy (DR) retinas tissues streptozotocin treatment upregulated 31430717 413 Rat NR_046239.1 lncRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment upregulated 30373531 414 Rat NR_046246.1 lncRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment upregulated 30373531 415 Rat NR_110713 lncRNA methamphetamine (METH) neurotoxicity prefrontal cortical neurons Methamphetamine treatment upregulated 28619521 416 Rat Nrf2 lncRNA doxorubicin (DOX) doxorubicin (DOX)-induced dysfunction cardiomyocytes doxorubicin (DOX) treatment upregulated 27261628 417 Rat Nup214 lncRNA NiSO4 steroidogenesis disturbance rat Leydig cells NiSO4 treatment upregulated 31734292 418 Rat OGRU lncRNA high glucose (HG) diabetic retinopathy (DR) M¨¹ller cells high glucose (HG) treatment DR patients exhibited significantly increased expression of serum LncRNA-OGRU compared with normal individuals. Streptozotocin (STZ)-challenged rats with DR also had higher OGRU expression in retinas 33762162 419 Rat OIP5-AS1 lncRNA high glucose (HG) diabetic cardiomyopathy (DCM) H9c2 cells high glucose treatment OIP5-AS1 overexpression promotes viability and inhibits high glucose-induced oxidative stress of cardiomyocytes by targeting microRNA-34a/SIRT1 axis in diabetic cardiomyopathy. 33380310 420 Rat Oip5-as1 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment "Oip5-as1 suppresses miR-29a leading to activation of the SIRT1/AMPK/PGC1¦Á pathway, which attenuates mitochondria-mediated apoptosis during MI/R injury" 32468629 421 Rat OIP5-AS1 lncRNA freund¡¯s complete adjuvant (FCA) rheumatoid arthritis (RA) synovial tissues Freund¡¯s complete adjuvant (FCA) treatment lncRNA OIP5-AS1 may mitigate RA progression through the miR-448-PON1 axis and through the inactivation of the TLR3-NF-¦ÊB signalling pathway. 32770578 422 Rat PACER lncRNA dexmedetomidine (DEX) chronic obstructive pulmonary disease (COPD) primary rat alveolar epithelial cells dexmedetomidine (Dex) treatment "DEX induction decreased PACER expression, and proliferative and migratory abilities in primary rat alveolar epithelial cells harvested from COPD rats." 33378047 423 Rat PEAMIR lncRNA particulate matter (PM2.5) ischemia/reperfusion (I/R) injury H9c2 cells PM2.5 exposure treatment LncRNA NR_136400 Suppresses Cell Proliferation and Invasion by Acting as a ceRNA of TUSC5 That Is Modulated by miR-8081 in Osteosarcoma 32100595 424 Rat PEBP1P2 lncRNA platelet derived growth factor-BB (PDGF-BB) proliferative vascular diseases vascular smooth muscle cells (VSMCs) platelet-derived growth factor BB (PDGF-BB) treatment downregulated 32916601 425 Rat PEG10 lncRNA H2O2 spinal cord injury (SCI) rat PC-12 cells H2O2 treatment Knockdown PEG10 deteriorated H2O2-injury. 31835090 426 Rat PEG10 lncRNA H2O2 spinal cord injury (SCI) PC-12 cells H2O2 treatment Knockdown PEG10 remitted H2O2-injury of PC-12 cells by targeting miR-34a-5p/TLX. 31835090 427 Rat PTENP1 lncRNA lipopolysaccharide (LPS) cardiac dysfunction H9C2 cells lipopolysaccharide (LPS) treatment upregulated 33341669 428 Rat PTENP1 lncRNA matrine cardiac dysfunction LPS-treated H9C2 cells matrine treatment downregulated 33341669 429 Rat PTENP1 lncRNA matrine cardiac dysfunction H9c2 cells Matrine treatment downregulated 33341669 430 Rat PVT1 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) acute ischemic stroke (AIS) PC12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 32827544 431 Rat PVT1 lncRNA curcumin (Cur) acute kidney injury (AKI) NRK cells curcumin treatment Curcumin decreased PVT1 expression in LPS-induced septic acute kidney tissues and reduced LPS-induced septic acute kidney injury in mice. 31972207 432 Rat PVT1 lncRNA respiratory syncytial virus (RSV) asthma Sprague-Dawley rat respiratory syncytial virus (RSV) infection treatment upregulated 28510638 433 Rat PVT1 lncRNA doxorubicin (DOX) cardiotoxicity H9c2 cells Doxorubicin (DOX) treatment Doxorubicin promotes H9c2 apoptosis and increased PVT1 expression in cardiomyocytes. 31786333 434 Rat PVT1 lncRNA streptozocin (STZ) diabetes mellitus (DM) rat insulinoma (INS-1) cells streptozotocin (STZ) treatment Silencing of lncRNA PVT1 ameliorates streptozotocin-induced pancreatic ¦Â cell injury and enhances insulin secretory capacity by regulating miR-181a-5p 32758099 435 Rat PVT1 lncRNA danggui buxue tang (DBT) diabetic nephropathy (DN) rats danggui buxue tang (DBT) treatment downregulated 28861164 436 Rat PVT1 lncRNA doxorubicin (DOX) doxorubicin (DOX)-induced cardiotoxicity H9c2 cells doxorubicin (DOX) treatment Doxorubicin promotes H9c2 apoptosis and increased PVT1 expression in cardiomyocytes. 31786333 437 Rat PVT1 lncRNA lithium chloride and pilocarpine epilepsy hippocampus tissues lithium chloride-pilocarpine treatment upregulated 30805931 438 Rat PVT1 lncRNA complete freund's adjuvant (CFA) rheumatoid arthritis (RA) synovial tissues and RA fibroblast-like synoviocyte (RA-FLS) complete Freund¡¯s adjuvant (CFA) treatment upregulated 31303891 439 Rat RGD1566344 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) PC-12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 32424772 440 Rat RGD1566344 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) PC12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment "In this study, we found that RGD1566344 levels were elevated in the ischemic infarct and penumbra regions 12 h after middle cerebral artery occlusion/reperfusion (MCAO/R) in male mice and in PC12 cells with oxygen glucose deprivation/reperfusion (OGD/R)" 32424772 441 Rat Rian lncRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia treatment upregulated 32187165 442 Rat RMRP lncRNA abdominal aortic coarctation cardiac fibrosis heart tissues abdominal aortic banding treatment lncRNA RMRP expression was upregulated in the presence of cardiac fibrosis in an abdominal aortic banding-treated rat model. 31485650 443 Rat RMRP lncRNA angiotensin II (Ang II) cardiac fibrosis cardiac fibroblast angiotensin II (Ang II) treatment "Treatment with angiotensin II increased RMRP expression in cardiac fibroblasts, while the knockdown of RMRP by small-interfering RNA inhibited cardiac fibroblast proliferation, differentiation and collagen accumulation." 31485650 444 Rat RMRP lncRNA hypoxia myocardial injury H9c2 cells hypoxia exposure LncRNA RMRP accelerates hypoxia-induced injury by targeting miR-214-5p in H9c2 cells. 31839421 445 Rat RMRP lncRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) The H9c2 cardiomyocytes hypoxia induce upregulated 30551524 446 Rat RMRP lncRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia treatment Hypoxia promoted the expression of RMRP in H9c2 cells. 30551524 447 Rat Rn50_X_0711.1 lncRNA lipopolysaccharide (LPS) hepatocarcinogenesis WB-F344 cells lipopolysaccharide (LPS) treatment upregulated 31065105 448 Rat RNF7 lncRNA angiotensin II (Ang II) cardiac fibrosis cardiac fibroblasts angiotensin II (Ang II) treatment RNF7 promotes the cardiac fibrosis in rat model via miR-543/THBS1 axis and TGF¦Â1 activation. 31913855 449 Rat ROR lncRNA hypoxia chronic hypoxic heart disease (CHD) H9c2 cells hypoxia induce "We found that lncRNA-ROR was elevated by hypoxia in H9c2 cells. LncRNA-ROR overexpression was able to relieve the damages of H9c2 cells induced by hypoxia through rescuing viability, suppressing apoptosis, and blocking Cytochrome c release" 31190357 450 Rat ROR lncRNA hypoxia/reoxygenation (H/R) ischemia/reperfusion (I/R) injury H9c2 cells hypoxia/reoxygenation (H/R) treatment lncRNA-ROR was upregulated in H9c2 cells. 29694511 451 Rat ROR lncRNA hypoxia ischemic stroke (IS) PC12 cells hypoxia induce upregulated 31632583 452 Rat ROR lncRNA Skullcapflavone I (SF I) myocardial infarction (MI) hypoxia-stimulated H9c2 cells and primary cardiomyocytes. Skullcapflavone I (SF I) treatment SF I promoted the hypoxia-caused upregulated of lincRNA-ROR in H9c2 cells and primary cardiomyocytes 31220954 453 Rat ROR lncRNA ischemia myocardial ischemia/reperfusion (I/R) injury (MIRI) heart tissues the proximal left anteriordescending coronaryartery (LAD) was loosely ligated by a 6¨C0 silk suture lncRNA ROR were upregulated in both MIRI rat model and H/R treated HCMs. 31768721 454 Rat RP11-513I15.6 lncRNA diethylnitrosamine and 2-acetylaminofluorene precancerous lesion (PCL) liver tissues diethylnitrosamine and 2-acetylaminofluorene treatment upregulated 31009125 455 Rat RP11-513I15.6 lncRNA pantoprazole precancerous lesion (PCL) liver tissues pantoprazole treatment downregulated 31009125 456 Rat RP11-583F2.2 lncRNA diethylnitrosamine and 2-acetylaminofluorene hepatic ischemia/reperfusion injury (HIRI) Liver tissues and blood samples diethylnitrosamine and 2-acetylaminofluorene treatment upregulated 31489981 457 Rat RP11-583F2.2 lncRNA hesperidin hepatic precancerous lesion (HPC) hepatic precancerous lesion (HPC) rat liver tissues and blood samples Hesperidin treatment downregulated 31489981 458 Rat RP4 lncRNA hypoxia ischemic heart disease (IHD) H9c2 cardiac muscle cells hypoxia induce upregulated 31321998 459 Rat RPT lncRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) pulmonary artery smooth muscle cells (PASMCs) monocrotaline (MCT) treatment downregulated of LnRPT was also observed in the pulmonary arteries of rats with monocrotaline-induced PAH. 28915060 460 Rat RPT lncRNA platelet derived growth factor-BB (PDGF-BB) pulmonary arterial hypertension (PAH) pulmonary artery smooth muscle cells (PASMCs) platelet-derived growth factor (PDGF)-BB treatment LnRPT was downregulated significantly in responding PDGF-BB 28915060 461 Rat rPvt1 lncRNA lipopolysaccharide (LPS) sepsis-induced myocardial injury rat heart samples lipopolysaccharide (LPS) treatment lncRNA rPvt1 showed significant upregulation in the sepsis group 31472370 462 Rat RT1-CE5-002 lncRNA letrozole polycystic ovarian syndrome (PCOS) ovarian tissues letrozole treatment upregulated 29505837 463 Rat RT1-M3-1-002 lncRNA letrozole polycystic ovarian syndrome (PCOS) ovarian tissues letrozole treatment upregulated 29505837 464 Rat S69206 lncRNA bleomycin (BLM) lung fibrosis fibrotic lung tissues bleomycin (BLM) treatment upregulated 23732278 465 Rat SHNG16 lncRNA dexamethasone (DEX) neuronal cell injury brain tissues dexamethasone (Dex) treatment upregulated 32323054 466 Rat SHNG16 lncRNA hypoxia neuronal cell injury brain tissues middle cerebral artery occlusion (MCAO) surgery downregulated 32323054 467 Rat sirt1-AS lncRNA astragaloside IV (AS-IV) idiopathic pulmonary fibrosis (IPF) RLE-6TN astragaloside IV (AS-IV) treatment upregulated 32139663 468 Rat Slc25a52 lncRNA lipopolysaccharide (LPS) hepatocarcinogenesis WB-F344 cells lipopolysaccharide (LPS) treatment upregulated 31065105 469 Rat SNHG1 lncRNA kainic acid (KA) epilepsy CTX-TNA2 cells kainic acid (KA) treatment SNHG1 expression was downregulated in EP tissues and kainic acid (KA)-induced CTX-TNA2 cells. 33359246 470 Rat SNHG1 lncRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC-12 cells lipopolysaccharide (LPS) treatment "SNHG1 regulated cell viability, apoptosis and autophagy in LPS-treated PC12 cells" 33515352 471 Rat SNHG12 lncRNA hypoxia ischemia/reperfusion (I/R) injury rat brain microvascular endothelial cells (BMECs) hypoxia induce upregulated 31293373 472 Rat SNHG12 lncRNA H2O2 ischemia/reperfusion (I/R) injury HT22 cells oxidative stress treatment lncRNA SNHG12 increased cell activity and inhibited oxidative stress through inhibition of SIRT1/FOXO3a signaling-mediated autophagy in HT22 cells of I/R model. 32718291 473 Rat SNHG12 lncRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia-reoxygenation (H/R) treatment "Here, we found the increase of the SNHG12 level in hypoxia-reoxygenation (H/R)-injured-H9c2 cells." 33589923 474 Rat SNHG14 lncRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment upregulated 32436661 475 Rat SNHG14 lncRNA hypoxia cyanotic congenital heart disease (CCHD) H9c2 cells hypoxia induce "SNHG14 and KLF4 were upregulated, whereas miR-25-3p was downregulated in hypoxia-induced H9c2 cells and cardiac tissues of patients with CCHD compared with their controls." 33278191 476 Rat SNHG14 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) PC-12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment ?lncRNA-small nucleolar RNA host gene 14 (SNHG14) was found upregulated oxygen-glucose deprivation and reoxygenation (OGD/R) treated PC-12 cells 30546117 477 Rat SNHG14 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) PC-12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment lncRNA-small nucleolar RNA host gene 14 (SNHG14) was found upregulated in oxygen-glucose deprivation and reoxygenation (OGD/R) treated PC-12 cells 30546117 478 Rat SNHG14 lncRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC-12 cells lipopolysaccharide (LPS) treatment ?Bioinformatics prediction and luciferase reporter assay demonstrated that miR-181b-5p could directly bind to SNHG14. 33791006 479 Rat SNHG15 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) PC12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 33528807 480 Rat SNHG16 lncRNA H2O2 spinal cord injury (SCI) PC-12 cells H2O2 treatment downregulated 30977409 481 Rat SNHG3 lncRNA oxygen glucose deprivation (OGD) intracerebral haemorrhage (ICH) primary brain microvascular endothelial cells (BMVECs) oxygen-and-glucose-deprivation (OGD) plus hemin induce treatment "In ICH rats, downregulated of Snhg3 by siRNA injection improved behavioral and histological manifestations, including number of right turns, limb placement score, integrity of blood-brain barrier (BBB), brain water content and cell apoptosis in vivo" 31610210 482 Rat SNHG4 lncRNA puromycin aminonucleoside (PAN) glomerular injury primary rat podocytes puromycin aminonucleoside (PAN) treatment upregulated 30597036 483 Rat SNHG7 lncRNA angiotensin II (Ang II) cardiac hypertrophy neonatal rat cardiomyocytes (NRCMs) angiotensin II (Ang II) treatment upregulated 31026094 484 Rat SNHG7 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) PC12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment SNHG7 was downregulated and miR-9 was upregulated by OGD/R treatment in PC12 cells 33262598 485 Rat SNHG8 lncRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia treatment lncRNA SNHG8 affected myocardial infarction by affecting hypoxia-induced cardiomyocyte injury via regulation of the NF-kappaB pathway. 32772038 486 Rat SOX2OT lncRNA lipopolysaccharide (LPS) sepsis-induced myocardial injury H9c2 (rat cardiomyocyte cell line) lipopolysaccharide (LPS) treatment upregulated 31618067 487 Rat SOX2OT lncRNA H2O2 spinal cord injury (SCI) PC-12 cells hydrogen peroxide (H2O2 ) treatment Sox2ot expression was significantly increased after H2O2 treatment compared with control. 30145837 488 Rat SOX2OT lncRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC-12 cells lipopolysaccharide (LPS) treatment SOX2OT was elevated in SCI rat and cell models. 33340723 489 Rat SOX2OT lncRNA doxorubicin (DOX) cardiomyocyte apoptosis Primary cardiomyocytes ?doxorubicin (DOX) treatment "SOX2-OT and DP5 were highly expressed, while miR-942-5p was downregulated in DOX-treated primary cardiomyocytes and rat model" 33603338 490 Rat SRA1 lncRNA angiotensin II (Ang II) cardiac fibrosis Cardiac myofibroblasts angiotensin II (Ang II) treatment "Ang-II treatment increased the SRA1 expression of cardiac myofibroblasts, whereas SRA1 knockdown by siRNA inhibited the proliferation, myofibroblast conversion, and collagen production of cardiac myofibroblasts induced by Ang-II." 30694702 491 Rat SRA1 lncRNA hypoxia hypoxia-induced injury H9c2 cells hypoxia treatment hypoxia resulted in a decreased expression of SRA1 in H9c2 cardiomyocytes. 31949848 492 Rat SULT1C2A lncRNA vitamin A congenital scoliosis (CS) Embryos Vitamin A deficiency treatment downregulated 31044535 493 Rat TALNEC2 lncRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia induce upregulated 30861181 494 Rat Tap1 lncRNA NiSO4 steroidogenesis disturbance rat Leydig cells NiSO4 treatment downregulated 31948324 495 Rat TapSAKI lncRNA escherichia coli (E.coli) sepsis-induced acute kidney injury kidney tissues Escherichia coli infection "TapSAKI was elevated in urine derived sepsis-induced kidney injury, and promoted HK-2 cell apoptosis and inflammatory response through miR-22/PTEN/TLR4/NF-¦ÊB pathway." 30666657 496 Rat TCF7 lncRNA hypoxia myocardial infarction (MI) Mesenchymal stem cells (MSCs) hypoxia induce upregulated 30814673 497 Rat TCF7 lncRNA integrin-linked kinase (ILK) myocardial infarction (MI) Mesenchymal stem cells (MSCs) integrin-linked kinase (ILK) overexpression upregulated 30814673 498 Rat TCONS_00041960 lncRNA glucocorticoid (GC) adipogenic and osteogenic differentiation bone marrow mesenchymal stem cells (BMSCs) glucocorticoid treatment we found downregulated of TCONS_00041960 during adipogenic and osteogenic differentiation of glucocorticoid-treated bone marrow mesenchymal stem cells (BMSCs). 29319166 499 Rat TCONS_00052110 lncRNA lipopolysaccharide (LPS) heart failure (HF) myocardium lipopolysaccharide (LPS) treatment upregulated 30119177 500 Rat TCONS_00201718 lncRNA lipopolysaccharide (LPS) heart failure (HF) myocardium lipopolysaccharide (LPS) treatment upregulated 30119177 501 Rat TCONS_00202959 lncRNA acetylcholine-CaCl2 solution atrial fibrillation (AF) heart tissues acetylcholine-CaCl2 solution treatment The expression of lncRNA TCONS_00202959 was decreased in the AF group compared to the control group. 30575932 502 Rat TCONS_00296056 lncRNA lipopolysaccharide (LPS) heart failure (HF) myocardium lipopolysaccharide (LPS) treatment downregulated 30119177 503 Rat TCONS-00088786 lncRNA TGF-¦Â renal fibrosis rat renal tubular epithelial NRK-52E cells TGF-¦Â treatment upregulated 28912732 504 Rat TCONS-01496394 lncRNA TGF-¦Â renal fibrosis rat renal tubular epithelial NRK-52E cells TGF-¦Â treatment upregulated 28912732 505 Rat THRIL lncRNA geniposide (GEN) myocardial infarction (MI) H9c2 cells Geniposide (GEN) treatment downregulated 30953616 506 Rat THRIL lncRNA hypoxia myocardial infarction (MI) H9C2 cells hypoxia induce upregulated 29745968 507 Rat THRIL lncRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia treatment Hypoxia induced an increase of THRIL but a reduction of miR-99a and Brg1. 29745968 508 Rat THRIL lncRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia induce upregulated 30953616 509 Rat TINCR lncRNA doxorubicin (DOX) cardiotoxicity Primary neonatal rat cardiomyocytes (PNRC) and H9c2 cells Doxorubicin (DOX) treatment upregulated 31445005 510 Rat TINCR lncRNA hypoxia/reoxygenation (H/R) ischemia/reperfusion (I/R) injury H9c2 cells hypoxia/reoxygenation (H/R) treatment "MpostC-induced upregulated of TINCR protects cardiomyocytes from I/R injury via inhibiting degradation and ubiquitination of FGF1, and subsequently activating PKC¦Å signaling pathway." 32176291 511 Rat TNFRSF17 lncRNA hypoxia hypoxic/ischemic brain damage (HIBD) neonatal rat brain after HIBD hypoxia induce downregulated 31949607 512 Rat TTTY15 lncRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) PC12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment The results of the present study revealed that TTTY15 expression was upregulated in OGD/R-treated PC12 cells 33791020 513 Rat TUG1 lncRNA diosmetin (DIOS) acute kidney injury (AKI) RMC cells diosmetin (DIOS) treatment upregulated 33182044 514 Rat TUG1 lncRNA lipopolysaccharide (LPS) acute kidney injury (AKI) RMC cells lipopolysaccharide (LPS) treatment downregulated 33182044 515 Rat TUG1 lncRNA zhenbao pill acute spinal cord injury (ASCI) cultured CD4+ T cells Zhenbao Pill treatment upregulated 30287503 516 Rat TUG1 lncRNA metformin (Met) atherosclerosis (AS) aortic root tissue Metformin treatment Metformin prevent AS by activating the AMPK/mTOR pathway via lncRNA TUG1. 32099330 517 Rat TUG1 lncRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment Silencing TUG1 attenuated Ang II-induced cardiac hypertrophy. 31183682 518 Rat TUG1 lncRNA angiotensin II (Ang II) cardiac hypertrophy Primary cardiomyocytes angiotensin II (Ang II) treatment Our data indicated that TUG1 was upregulated and miR-497 was downregulated in the TAC rat model and Ang II-induced cardiomyocytes. 33817315 519 Rat TUG1 lncRNA hypoxia cell damage H9c2 cells hypoxia treatment downregulated 29864957 520 Rat TUG1 lncRNA sacubitril/valsartan (LCZ696) chemotherapy-induced testicular atrophy testicular LCZ696 treatment "LCZ696 increased lncRNA TUG1 expression, improved sperm characteristics, hormonal profile, testicular function, antioxidant defences, and Bcl-2" 32197949 521 Rat TUG1 lncRNA high glucose (HG) diabetic nephropathy (DN) Mesangial cells high glucose treatment downregulated 31539141 522 Rat TUG1 lncRNA high glucose (HG) diabetic nephropathy (DN) NRK-52E cells high glucose treatment downregulated 31933879 523 Rat TUG1 lncRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissues streptozocin (STZ) treatment downregulated 31539141 524 Rat TUG1 lncRNA hypoxia hypoxia-induced cardiac dysfunctions H9c2 cells hypoxia treatment Hypoxia treatment significantly increased the expression level of TUG1. 29207102 525 Rat TUG1 lncRNA H2O2 myocardial infarction (MI) cultured cardiomyocytes H2O2 treatment upregulated 31787746 526 Rat TUG1 lncRNA hypoxia myocardial ischaemic injury cardiomyocyte cell line H9c2 hypoxia upregulated 29207102 527 Rat TUG1 lncRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) treatment TUG1 silence ameliorated H/R-induced cardiomyocytes injury through regulating miR-532-5p/Sox8 axis. 32833900 528 Rat TUG1 lncRNA lipopolysaccharide (LPS) myocarditis H9c2 cells lipopolysaccharide (LPS) treatment TUG1 expression was downregulated in LPS-injured H9c2 cells. 29518613 529 Rat TUG1 lncRNA ketamine neurotoxicity primary rat hippocampal neurons Ketamine (KET) treatment "small interfering TUG1 (siTUG1) decreased KET-induced hippocampal neurons apoptosis and ROS level, and increased hippocampal neurons viability." 30995880 530 Rat TUG1 lncRNA lipopolysaccharide (LPS) sepsis-induced acute kidney injury rat mesangial cells (RMCs) lipopolysaccharide (LPS) treatment downregulated 30834562 531 Rat TUG1 lncRNA lipopolysaccharide (LPS) spinal cord injury (SCI) ?PC-12 cell lipopolysaccharide (LPS) treatment "?LPS-induced decrease of cell viability, increase of apoptosis and release of IL-6 and TNF-¦Á were mitigated by TUG1 overexpression." 31326411 532 Rat uc.229 lncRNA manganese (Mn) neurotoxicity hippocampal neurons Manganese (Mn) treatment downregulated 26745496 533 Rat uc.242 lncRNA angiotensin II (Ang II) cardiac hypertrophy Primary cardiomyocytes angiotensin II (Ang II) treatment upregulated 33229398 534 Rat uc.242 lncRNA angiotensin II (Ang II) cardiac hypertrophy primary cardiomyocytes angiotensin II (Ang II) treatment upregulated 33229398 535 Rat uc.412 lncRNA TGF-¦Â1 cell proliferation The rat mesangial cell line RMC transforming growth factor ¦Â1 treatment upregulated 31638227 536 Rat uc.48 lncRNA high fat diet (HFD) diabetic neuropathic pain (DNP) Sprague-Dawley rats high fat diet (HFD) feed upregulated 31966886 537 Rat uc.48+ lncRNA high fat diet (HFD) myocardial ischemia/reperfusion (I/R) injury (MIRI) rat myocardium high fat diet (HFD) feed upregulated 30417395 538 Rat uc.48+ lncRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia induce upregulated 30417395 539 Rat uc.48+ lncRNA high fat diet (HFD) myocardial ischemia/reperfusion (I/R) injury (MIRI) left ventricular tissue high fat diet (HFD) feed uc.48+ was upregulated in HFD I/R myocardium. 30417395 540 Rat uc.80- lncRNA chronic unpredictable mild stress (CUMS) depression hippocampus chronic unpredictable mild stress (CUMS) treatment uc.80- was downregulated in hippocampus of depressed rats. 32780551 541 Rat UCA1 lncRNA lithium chloride and pilocarpine epilepsy brain tissues lithium chloride-pilocarpine treatment upregulated 28742194 542 Rat UCA1 lncRNA pilocarpine epilepsy hippocampus; hippocampal neurons pilocarpine treatment "The lncRNA UCA1 and Nrf2 were downregulated in epileptiform hippocampal tissues and neurons, while the miR-495 was upregulated" 29608952 543 Rat UCA1 lncRNA hypoxia hypoxia-induced injury neuronal pheochromocytoma (PC)-12 cells hypoxia treatment upregulated 319666702 544 Rat UCA1 lncRNA hypoxia ischemia/reperfusion (I/R) injury H9C2 cells hypoxia induce downregulated 30877641 545 Rat UCA1 lncRNA hypoxia myocardial infarction (MI) neonatal rat cardiomyocytes hypoxia induce downregulated 30998966 546 Rat UCA1 lncRNA hypoxia/reoxygenation (H/R) myocardial infarction (MI) cardiomyocytes hypoxia/reoxygenation (H/R) treatment lncUCA1 might protect cardiomyocyte against H/R induced apoptosis by suppressing miR-143 and modulated the following downstream MDM2/p53 signaling pathway. 30998966 547 Rat UCA1 lncRNA 6-hydroxydopamine (6-OHDA) parkinson's disease (PD) dopaminergic neurons 6-hydroxydopamine (6-OHDA) treatment upregulated 31301558 548 Rat UCA1 lncRNA kainic acid (KA) temporal lobe epilepsy (TLE) hippocampal astrocyte kainic acid (KA) treatment UCA1 inhibited hippocampal astrocyte activation and JAK/STAT/GLAST expression in TLE rats and improved the adverse reactions caused by epilepsy. 31909503 549 Rat Urgcp-002 lncRNA letrozole polycystic ovarian syndrome (PCOS) ovarian tissues letrozole treatment upregulated 29505837 550 Rat URIDS lncRNA advanced glycation end product (AGE) diabetic foot ulcer (DFU) dermal fibroblasts advanced glycation end products (AGEs) treatment lnc-URIDS was highly expressed in diabetic skin and dermal fibroblasts treated with advanced glycation end products (AGEs). 32801140 551 Rat XIST lncRNA hypoxia cardiac injury H9c2 cells hypoxia induce Hypoxic H9c2 cells demonstrated a decrease in their migration and invasion abilities and lncRNA XIST expression. 31887421 552 Rat XIST lncRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia treatment "XIST protects cardiomyocytes from hypoxia-induced injury by mediating miR-150-5p/Bax axis, suggesting that XIST is an important target for AMI treatment." 32096185 553 Rat XIST lncRNA amyloid-¦Â (A¦Â) 25-35 Alzheimer's disease (AD) Primary hippocampal neuron amyloid-¦Â (A¦Â) 25-35 treatment A¦Â25-35 treatment increased XIST expression in hippocampal neurons. 31949779 554 Rat XIST lncRNA hypoxia cardiac injury H9c2 cells hypoxia treatment Hypoxic H9c2 cells demonstrated a decrease in XIST expression. 31887421 555 Rat XIST lncRNA hypoxia cardiac injury H9c2 cells hypoxia exposure "XIST expressions of cardiomyocyte line, H9c2 were apparently suppressed by long-time hypoxia exposure under low glucose supply." 32415544 556 Rat XIST lncRNA ioversol contrast-induced nephropathy (CIN) kidney tissues ioversol treatment upregulated 33387208 557 Rat XIST lncRNA lipopolysaccharide (LPS) epilepsy CTX-TNA2 (CRL-2006) astrocyte cell line lipopolysaccharide (LPS) treatment upregulated 33776905 558 Rat XIST lncRNA pentylenetetrazol (PTZ) epilepsy dorsal hippocampus pentylenetetrazol treatment upregulated 33776905 559 Rat XIST lncRNA phenylephrine (PE) hypertrophy cardiomyoblast H9c2 cells phenylephrine (PE) induce treatment The expression of XIST was significantly upregulated in PE-treated cardiomyocytes Knockdown of XIST attenuated PE-induced cardiomyocyte hypertrophy 30605239 560 Rat XIST lncRNA complete freund's adjuvant (CFA) inflammatory pain dorsal root ganglion (DRG) complete Freund's adjuvant (CFA) treatment upregulated 30129228 561 Rat XIST lncRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells hypoxia/reoxygenation (H/R) induce upregulated 31734557 562 Rat XIST lncRNA chronic constriction injury (CCI) neuropathic pain (NP) rats chronic constriction injury (CCI) induce upregulated 29115665 563 Rat XIST lncRNA 1-methyl-4-phenylpyridinium (MPP+) parkinson's disease (PD) PC-12 cells 1-methyl-4-phenylpyridinium (MPP+) treatment upregulated 33494069 564 Rat XIST lncRNA cannabinoid receptor type II (CB2R) parkinson's disease (PD) PC12 cells cannabinoid receptor type II (CB2R) treatment CB2 receptor agonist AM1241 alleviated PD via regulation of the Xist/miR-133b-3p/Pitx3 axis. 31989652 565 Rat XIST lncRNA lipopolysaccharide (LPS) spinal cord injury (SCI) microglial cells lipopolysaccharide (LPS) treatment XIST was significantly higher in LPS-induced primary microglial cells. 31778769 566 Rat XIST lncRNA lipopolysaccharide (LPS) spinal cord injury (SCI) mouse primary microglial cells lipopolysaccharide (LPS) treatment "higher level of XIST and Smurf1, but lower level of miR-27a in SCI rats and lipopolysaccharide (LPS)-induced primary microglial cells." 31778769 567 Rat XR_005513 lncRNA ischemia stroke rat cortical tissues focal ischemia treatment upregulated 24063527 568 Rat XR_007793 lncRNA platelet derived growth factor-BB (PDGF-BB) neointimal formation rat aortic smooth muscle cells platelet-derived growth factor (PDGF)-BB treatment XR007793 expression was significantly increased in the injured carotid artery of Sprague-Dawley rats and platelet-derived growth factor-BB induced rat aortic smooth muscle cells 30141428 569 Rat XR_007793 lncRNA pathological hypertensive cyclic strain cell proliferation and migration vascular smooth muscle cells (VSMCs) of spontaneously hypertensive rats and Wistar-Kyoto rats Flexcell-4000T treatment upregulated 28319593 570 Rat XR_086062.1 lncRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment upregulated 30373531 571 Rat XR_145872.1 lncRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment upregulated 30373531 572 Rat XR_145894.1 lncRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment downregulated 30373531 573 Rat XR_146480.1 lncRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment downregulated 30373531 574 Rat XR_146737.1 lncRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment upregulated 30373531 575 Rat XR_344474 lncRNA chronic intermittent hypoxia (CIH) obstructive sleep apnea-induced cardiovascular disease heart tissues chronic intermittent hypoxia (CIH) treatment upregulated 30535531 576 Rat XR_590196 lncRNA chronic intermittent hypoxia (CIH) obstructive sleep apnea-induced cardiovascular disease heart tissues chronic intermittent hypoxia (CIH) treatment downregulated 30535531 577 Rat XR_596701 lncRNA chronic intermittent hypoxia (CIH) obstructive sleep apnea-induced cardiovascular disease heart tissues chronic intermittent hypoxia (CIH) treatment upregulated 30535531 578 Rat XR_597099 lncRNA chronic intermittent hypoxia (CIH) obstructive sleep apnea-induced cardiovascular disease heart tissues chronic intermittent hypoxia (CIH) treatment downregulated 30535531 579 Rat XR_600374 lncRNA chronic intermittent hypoxia (CIH) obstructive sleep apnea-induced cardiovascular disease heart tissues chronic intermittent hypoxia (CIH) treatment downregulated 30535531 580 Rat ZEB1-AS1 lncRNA bleomycin (BLM) lung fibrosis rat lung tissues bleomycin (BLM) treatment upregulated 30755599 581 Rat ZEB1-AS1 lncRNA TGF-¦Â1 lung fibrosis RLE-6TN cells TGF-¦Â1 treatment upregulated 30755599 582 Rat ZFAS1 lncRNA hypoxia/reoxygenation (H/R) acute myocardial infarction (AMI) H9c2 cells hypoxia/reoxygenation (H/R) treatment "ZFAS1 was upregulated in H9c2 cells subjected to I/R injury, and that ZFAS1 knockdown protected against I/R-induced myocardial cell apoptosis by directly interacting with miR-590-3p, via the NF-¦ÊB pathway." 32705215 583 Rat ZFAS1 lncRNA bleomycin (BLM) lung fibrosis lung tissues bleomycin (BLM) treatment upregulated 32453709 584 Rat ZFAS1 lncRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues; NR8383 cells lipopolysaccharide (LPS) treatment rats in LPS group also resulted in a decrease in ZFAS1 expression and increase in miR-193a-3p expression in lung tissues 33848686