ID Species ncRNA ncRNA type Environmental factor (EF) Phenotype Sample Condition of EF Evidence PubMed ID 1 Rat rno-let-7 miRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues endotoxin treatment upregulated 26137246 2 Rat rno-let-7 miRNA "2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)" colorectal cancer (CRC) rat tumors; colonic mucosa tissues "2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) treatment" the let-7/c-Myc/Lin28 axis is dysregulated in heterocyclic amine-induced colon carcinogenesis 22641368 3 Rat rno-let-7 miRNA pilocarpine epilepsy adult male rats brain tissue and heart tissue 50 days of pilocarpine treatment downregulated in heart tissue 24530830 4 Rat rno-let-7 miRNA curcumin (Cur) neuroinflammation neuroinflammatory rat "co- of both compounds (Cur or VPA, 200 mg/kg) for 4 weeks treatment" upregulated 25374508 5 Rat rno-let-7a miRNA sevoflurane (SEV) acute lung injury (ALI) lung tissues sevoflurane treatment downregulated 28617947 6 Rat rno-let-7a miRNA infarct the LV free wall acute myocardial infarction (AMI) heart tissues left anterior descending coronary artery (LAD) was ligated using a 5/0 silk thread treatment downregulated 24758696 7 Rat rno-let-7a miRNA angiotensin II (Ang II) cardiac hypertrophy neonatal rat ventricular myocytes (NRVMs) angiotensin II (Ang II) treatment downregulated 28123343 8 Rat rno-let-7a miRNA formaldehyde formaldehyde inducted immune/inflammation rats were exposed to formaldehyde treatment downregulated 24304932 9 Rat rno-let-7a miRNA vein graft model intimal hyperplasia (IH) rat vein graft treatment downregulated 24953987 10 Rat rno-let-7a miRNA enoxacin major depressive disorder (MDD) rats with 10 or 25 mg/kg enoxacin for 1 week treatment upregulated 24575053 11 Rat rno-let-7a miRNA hypoxia myocardial ischaemic injury neonatal rat ventricular myocytes hypoxia treatment downregulated 26655604 12 Rat rno-let-7a miRNA high fat diet (HFD) obesity rats high fat diet (HFD) feed dysregulated 24517225 13 Rat rno-let-7a miRNA rotenone (ROT) parkinson's disease (PD) striatum of parkinsonian rats rotenone exposure treatment upregulated 30267378 14 Rat rno-let-7a miRNA single dose irradiation radiation-induced lung injury (RILI) male Wistar rats lung tissues subjected to single dose irradiation with 20 Gy using 6 MV x-rays to the right lung treatment upregulated 24886372 15 Rat rno-let-7a-1 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 16 Rat rno-let-7a-2-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 17 Rat rno-let-7a-5p miRNA alcohol brain damage due to chronic heavy alcohol hippocampal tissues chronic alcohol administration upregulated 33228793 18 Rat rno-let-7a-5p miRNA high fat diet (HFD) obesity white adipose tissues high fat diet (HFD) feed upregulated 32366215 19 Rat rno-let-7a-5p miRNA FK506 osteogenesis rat bone marrow stromal cells (BMSCs) FK506 treatment downregulated 28560399 20 Rat rno-let-7a-5p miRNA herb-partitioned moxibustion ulcerative colitis (UC) UC rats colon tissues herb-partitioned moxibustion upregulated 28246536 21 Rat rno-let-7b miRNA oxygen oxygen-induced retinopathy (OIR) choroid and the retinal pigment epithelium oxygen treatment upregulated 31430465 22 Rat rno-let-7b miRNA burn injury burn-induced hyperglycemia rats serum 30% total body surface area (TBSA) upregulated 29069833 23 Rat rno-let-7b miRNA adriamycin (ADR) chronic myeloid leukemia (CML) K562 cells; KA cells adriamycin (ADR) treatment let-7b was downregulated in K562/ADM (KA) cells. 32856506 24 Rat rno-let-7b miRNA cisplatin (DDP) cisplatin (DDP)-induced nephrotoxicity renal tissue homogenate cisplatin treatment downregulated 32777238 25 Rat rno-let-7b miRNA pentoxifylline (PTX) cisplatin (DDP)-induced nephrotoxicity renal tissue homogenate pentoxifylline (PTX) treatment upregulated 32777238 26 Rat rno-let-7b miRNA antibiotics dysbacteria Sprague Dawley (SD) rats faeces treat with a combination of antibiotics for 8 week downregulated 29264965 27 Rat rno-let-7b miRNA kainic acid (KA) epilepsy rat hippocampus neurons kainic acid treatment LncRNA H19 could competitively bind to let-7b to promote hippocampal glial cell activation and epileptic seizures by targeting Stat3 in a rat model of temporal lobe epilepsy. 32648622 28 Rat rno-let-7b miRNA hypoxia hypoxic pulmonary hypertension (HPH) lung tissues and pulmonary artery smooth muscle cells (PASMCs) hypoxia induce upregulated 30628484 29 Rat rno-let-7b miRNA verapamil male fertility testis verapamil treatment downregulated 32725937 30 Rat rno-let-7b miRNA ethanol (EtOH) neuroimmune rat hippocampal-entorhinal cortex (HEC) ethanol treatment upregulated 28118842 31 Rat rno-let-7b miRNA estradiol-17¦Â (E2) osteogenesis primary bone marrow mesenchymal stem cells from rats (rBMSCs) estradiol-17¦Â (E2) treatment upregulated 31089333 32 Rat rno-let-7b miRNA hypoxia pulmonary hypertension (PH) Sprague-Dawley (SD) rats remodeled pulmonary artery were exposed to hypoxia (10% O2) for 21days downregulated in remodeled pulmonary artery 27889560 33 Rat rno-let-7b miRNA TGF-¦Â1 renal fibrosis Rat proximal tubular epithelial cells (NRK52E) Transforming growth factor-¦Â1 treatment downregulated 24088962 34 Rat rno-let-7b miRNA TGF-¦Â1 renal fibrosis NRK52E cells TGF-¦Â1 treatment downregulated 24088962 35 Rat rno-let-7b-5p miRNA "2,5-hexanedione (HD)" "2,5-hexanedione (HD) toxicity" spinal cord tissues "2,5-hexanedione (HD) treatment" upregulated 31760062 36 Rat rno-let-7b-5p miRNA electroacupuncture (EA) analgesic effects brain tissues Electroacupuncture (EA) treatment MicroRNA Let-7b-5p Induces Electroacupuncture Tolerance by Downregulating the MKP-1 Gene in Rats Subjected to CFA-induced Inflammatory Nociception. 32240501 37 Rat rno-let-7b-5p miRNA electroacupuncture (EA) chronic nociception hypothalamus electroacupuncture (EA) treatment Let-7b-5p promotes electroacupuncture tolerance by downregulating Penk1 gene in CFA-induced inflammatory nociception rats. 32184167 38 Rat rno-let-7b-5p miRNA glucocorticoid (GC) respiratory distress syndrome lung Glucocorticoids treatment upregulated 26997989 39 Rat rno-let-7b-5p miRNA smoking smoke inhalation injury (SII) bronchoalveolar lavage fluid (BALF) Smoke inhalation treatment upregulated 30139538 40 Rat rno-let-7c miRNA infarct the LV free wall acute myocardial infarction (AMI) heart tissues left anterior descending coronary artery (LAD) was ligated using a 5/0 silk thread treatment downregulated 24758696 41 Rat rno-let-7c miRNA aluminum (Al) Alzheimer's disease (AD) PC-12 cells aluminum treatment downregulated 28222524 42 Rat rno-let-7c miRNA curcumin (Cur) Alzheimer's disease (AD) aluminum-induced PC-12 cells curcumin treatment upregulated 28222524 43 Rat rno-let-7c miRNA resveratrol Alzheimer's disease (AD) aluminum-induced PC-12 cells resveratrol treatment upregulated 28222524 44 Rat rno-let-7c miRNA formaldehyde formaldehyde inducted immune/inflammation rats were exposed to formaldehyde treatment downregulated 24304932 45 Rat rno-let-7c miRNA collagenase intracerebral haemorrhage (ICH) brain tissues harvested hemorrhagic brain 24 hours aftercollagenase induced ICH in the rat treatment upregulated 24959881 46 Rat rno-let-7c miRNA hypoxia/reoxygenation (H/R) ischemia/reperfusion (I/R) injury mesenchymal stem cell (MSC) exosome hypoxia-reoxygenation (H/R) treatment upregulated 32719674 47 Rat rno-let-7c miRNA single dose irradiation radiation-induced lung injury (RILI) male Wistar rats lung tissues subjected to single dose irradiation with 20 Gy using 6 MV x-rays to the right lung treatment upregulated 24886372 48 Rat rno-let-7c-1-3p miRNA methylprednisolone steroid-induced osteonecrosis of femoral head (ONFH) bone microvascular endothelial cells (BMECs) methylprednisolone treatment downregulated 29408208 49 Rat rno-let-7c-5p miRNA lipopolysaccharide (LPS) pulpitis Dental pulp stem cells (DPSCs) lipopolysaccharide (LPS) treatment downregulated 30238933 50 Rat rno-let-7c-5p miRNA lipopolysaccharide (LPS) pulpitis dental pulp stem cells (DPSCs) lipopolysaccharide (LPS) treatment downregulated 30575977 51 Rat rno-let-7c-5p miRNA glucocorticoid (GC) respiratory distress syndrome lung Glucocorticoids treatment upregulated 26997989 52 Rat rno-let-7c-5p miRNA smoking smoke inhalation injury (SII) bronchoalveolar lavage fluid (BALF) Smoke inhalation treatment upregulated 30139538 53 Rat rno-let-7d miRNA infarct the LV free wall acute myocardial infarction (AMI) heart tissues left anterior descending coronary artery (LAD) was ligated using a 5/0 silk thread treatment downregulated 24758696 54 Rat rno-let-7d miRNA TGF-¦Â1 diabetic nephropathy (DN) NRK-52E cells TGF-¦Â1 treatment downregulated 27693697 55 Rat rno-let-7d miRNA ethanol (EtOH) ethanol-related behaviors NAc tissues ethanol treatment Lentiviral-mediated upregulated of let-7d microRNA decreases alcohol intake through down-regulating the dopamine D3 receptor 32646740 56 Rat rno-let-7d miRNA high amplitude mechanical stretching lung fibrosis alveolar type II (ATII) cells and lung fibroblasts high amplitude mechanical stretching treatment upregulated 31290711 57 Rat rno-let-7d-5p miRNA herb-partitioned moxibustion ulcerative colitis (UC) UC rats colon tissues herb-partitioned moxibustion upregulated 28246536 58 Rat rno-let-7e miRNA infarct the LV free wall acute myocardial infarction (AMI) heart tissues left anterior descending coronary artery (LAD) was ligated using a 5/0 silk thread treatment downregulated 24758696 59 Rat rno-let-7e miRNA paraquat (PQ) apoptosis PC 12 cells paraquat (PQ) treatment downregulated 25174400 60 Rat rno-let-7e miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 61 Rat rno-let-7e-5p miRNA doxorubicin (DOX) ischemia/reperfusion (I/R) injury rats cardiomyocytes doxorubicin treatment upregulated 27919821 62 Rat rno-let-7f miRNA formaldehyde formaldehyde inducted immune/inflammation rats were exposed to formaldehyde treatment downregulated 24304932 63 Rat rno-let-7f-1-3p miRNA herb-partitioned moxibustion ulcerative colitis (UC) UC rats colon tissues herb-partitioned moxibustion upregulated 28246536 64 Rat rno-let-7f-2-3p miRNA doxorubicin (DOX) cardiotoxicity H9c2 cells doxorubicin (Dox)?treatment "let-7f-2-3p inhibition in mice alleviated Dox-induced cardiotoxicity and preserved the antitumor efficacy. Together, let-7f-2-3p regulated by lncRNA NEAT1 aggravates Dox-induced cardiotoxicity through inhibiting XPO1-mediated HAX-1 nuclear export" 31570982 65 Rat rno-let-7f-5p miRNA plastrum testudinis extracts (PTE) osteogenesis bone marrow mesenchymal stem cells (BMSCs) plastrum testudinis extracts (PTE) treatment upregulated 29975930 66 Rat rno-let-7g miRNA hypoxia pulmonary hypertension (PH) PASMCs hypoxia treatment downregulated 27889560 67 Rat rno-let-7g miRNA hypoxia pulmonary hypertension (PH) Sprague-Dawley (SD) rats remodeled pulmonary artery were exposed to hypoxia (10% O2) for 21days downregulated in remodeled pulmonary artery 27889560 68 Rat rno-let-7g miRNA hypoxia pulmonary hypertension (PH) SD Rats pulmonary arteries "were exposed to hypoxia (10% O2, 3 weeks)" downregulated in pulmonary arteries 28108289 69 Rat rno-let-7g miRNA rapamycin repair of epidermal growth factor (EGF) IEC-6 cells Rapamycin treatment downregulated 32301281 70 Rat rno-let-7g-5p miRNA gentamicin acute kidney injury (AKI) urine gentamicin treatment upregulated 33263228 71 Rat rno-let-7i miRNA sevoflurane (SEV) acute lung injury (ALI) lung tissues sevoflurane treatment downregulated 28617947 72 Rat rno-let-7i miRNA infarct the LV free wall acute myocardial infarction (AMI) heart tissues left anterior descending coronary artery (LAD) was ligated using a 5/0 silk thread treatment downregulated 24758696 73 Rat rno-let-7i miRNA icariside II (ICA II) erectile dysfunction (ED) adipose tissue-derived stem cells (ADSCs) IcarisideII (ICAII) treatment downregulated 31581950 74 Rat rno-let-7i miRNA dioscin liver fibrosis NRK-52E and HK-2 cells dioscin treatment upregulated 27431331 75 Rat rno-let-7i miRNA penetrating ballistic-like brain injury penetrating ballistic-like brain injury (PBBI) male Sprague-Dawley rats brain tissue a unilateral frontal 10% PBBI treatment upregulated in brain tissue 28452880 76 Rat rno-let-7i miRNA single dose irradiation radiation-induced lung injury (RILI) male Wistar rats lung tissues subjected to single dose irradiation with 20 Gy using 6 MV x-rays to the right lung treatment upregulated 24886372 77 Rat rno-let-7i miRNA blast traumatic brain injury (TBI) Blood and cerebrospinal fluid of rats blast treatment upregulated 22352906 78 Rat rno-let-8 miRNA lipopolysaccharide (LPS) neuroinflammation neuroinflammatory rat injection of (250 ¦Ìg/kg) lipopolysaccharide-stimulated neuroinflammatory rat treatment downregulated 25374508 79 Rat rno-miR-1 miRNA infusion of oleic acid (OA) acute lung injury (ALI) lung tissues OA (200 ?l/kg) suspended in 20% ethyl alcohol was injected through the tail vein for 20 min treatment dysregulated 24736893 80 Rat rno-miR-1 miRNA coronary artery ligation acute myocardial infarction (AMI) heart subjected to coronary artery ligation "serum miR-1 is quickly increased after AMI with a peak at 6 h, in which an increase in miR-1 of over 200-fold was demonstrated." 20218970 81 Rat rno-miR-1 miRNA glucose apoptosis ?rat cardiomyocyte cell line H9C2 glucose treatment upregulated 18801338 82 Rat rno-miR-1 miRNA doxycycline atrial fibrillation (AF) heart tissues doxycycline treatment downregulated 30470910 83 Rat rno-miR-1 miRNA doxycycline atrial fibrillation (AF) heart sissues doxycycline treatment upregulated 30470910 84 Rat rno-miR-1 miRNA astragaloside IV (AS-IV) cardiac dysfunction heart tissue of rats treated with LPS astragaloside (AS-IV) treatment downregulated 33774032 85 Rat rno-miR-1 miRNA lipopolysaccharide (LPS) cardiac dysfunction heart tissue lipopolysaccharide (LPS) treatment upregulated 33774032 86 Rat rno-miR-1 miRNA angiotensin II (Ang II) cardiac fibroblast proliferation primary ventricular fibroblasts angiotensin II (Ang II) treatment downregulated 31157242 87 Rat rno-miR-1 miRNA TGF-¦Â cardiac fibroblast proliferation adult rat ventricular fibroblasts TGF¦Â treatment downregulated 31157242 88 Rat rno-miR-1 miRNA T3 cardiac hypertrophy neonatal rat cardiac myocytes (NRCMs) treat with T3 for 24 hr treatment upregulated 28063219 89 Rat rno-miR-1 miRNA hexabromocyclododecane (HBCD) cardiac hypertrophy and arrhythmia rat cardiomyocyte cells Hexabromocyclododecane (HBCD) treatment "miR-1, which was depressed by Nkx2.5, might play a fundamental role in mediating cardiac hypertrophy and arrhythmia via its target genes Mef2a and Irx5 after HBCD treatment" 26476318 90 Rat rno-miR-1 miRNA ionizing radiation (IR) cardiogenic stress hearts ionizing radiation treatment downregulated 27643935 91 Rat rno-miR-1 miRNA doxorubicin (DOX) cardiomyocyte apoptosis H9c2 cells doxorubicin treatment upregulated 27284328 92 Rat rno-miR-1 miRNA ischemia cardiomyocyte apoptosis cardiomyocytes Ischemic postconditioning (IPost)treatment upregulated 21406115 93 Rat rno-miR-1 miRNA daunorubicin cardiomyopathy rats "daunorubicin (DAU-A, 3 mg/kg, every 48 h)" downregulated 28303410 94 Rat rno-miR-1 miRNA acute and long-term aerobic exercise cardiorespiratory fitness young men acute and long-term aerobic exercise treatment downregulated 27895662 95 Rat rno-miR-1 miRNA isoproterenol and doxorubicin cardiotoxicity rats plasma isoproterenol and doxorubicin treatment upregulated after treatment with doxorubicin 25092230 96 Rat rno-miR-1 miRNA high glucose (HG) diabetic cardiomyopathy (DCM) H9c2 cells high glucose (HG) treatment upregulated 30186406 97 Rat rno-miR-1 miRNA high glucose (HG) diabetic cardiomyopathy (DCM) cardiomyocytes high glucose (HG) treatment upregulated 27306406 98 Rat rno-miR-1 miRNA ivabradine electrophysiological cardiac remodelling heart of rat ?ivabradine treatment upregulated 21838751 99 Rat rno-miR-1 miRNA pilocarpine epilepsy adult male rats brain tissue and heart tissue 50 days of pilocarpine treatment downregulated in heart tissue 24530830 100 Rat rno-miR-1 miRNA angiotensin II (Ang II) hemorrhagic shock vascular smooth muscle cells (VSMCs) angiotensin II (Ang II) treatment AngII treatment reverses the upregulated of miR-1. 30419280 101 Rat rno-miR-1 miRNA angiotensin II (Ang II) hemorrhagic shock hypoxia-induced vascular smooth muscle cells (VSMCs) angiotensin II (Ang II) treatment downregulated 30419280 102 Rat rno-miR-1 miRNA hypoxia hemorrhagic shock vascular smooth muscle cells (VSMCs) hypoxia induce upregulated 30419280 103 Rat rno-miR-1 miRNA aloe-emodin (AE) HFD-induced cardiac electrical remodeling high-fat diet (HFD) rats hearts intragastrically administered with 100 mg/kg AE each day for 6 weeks downregulated in the hearts 29055952 104 Rat rno-miR-1 miRNA ionizing radiation (IR) irradiation-induced heart damage rat myocardium Single irradiation of 10 Gy (4¨C5 Gy/min.) of rat¡¯s mediastinum area upregulated 30830529 105 Rat rno-miR-1 miRNA molecular hydrogen-rich water (HRW) irradiation-induced heart damage irradiation-induced rat myocardium molecular hydrogen-rich water (HRW) treatment downregulated 30830529 106 Rat rno-miR-1 miRNA tanshinone IIA (Tan IIA) ischemic arrhythmias ?rat isolated ventricular myocytes Tanshinone IIA? treatment downregulated 19775284 107 Rat rno-miR-1 miRNA hypoxia ischemia/reperfusion (I/R) injury primary cultured cardiomyocyte hypoxia induce upregulated 31369209 108 Rat rno-miR-1 miRNA hypoxia/reoxygenation (H/R) ischemia/reperfusion (I/R) injury cardiomyocytes of neonatal rats hypoxia/reoxygenation (HR) injury treatment upregulated 25008997 109 Rat rno-miR-1 miRNA losartan ischemia/reperfusion (I/R) injury heart tissues losartan treatment upregulated 26168042 110 Rat rno-miR-1 miRNA telmisartan ischemia/reperfusion (I/R) injury hypoxia-induced primary cultured cardiomyocyte telmisartan treatment downregulated 31369209 111 Rat rno-miR-1 miRNA dantonic isoproterenol-induced myocardial ischemia (ISO-AMI) plasma dantonic treatment miR-1 level was significantly lower in both dantonic-administrated groups compared to LAD- AMI group. 30319429 112 Rat rno-miR-1 miRNA scopolamine memory loss "prefrontal cortex (PFC), the hippocampus and the amygdala tissues" scopolamine treatment upregulated 31400468 113 Rat rno-miR-1 miRNA carvedilol myocardial infarction (MI) H2O2 treated primary cultured cardiomyocyte carvedilol treatment downregulated 30896796 114 Rat rno-miR-1 miRNA H2O2 myocardial infarction (MI) primary cultured cardiomyocyte H2O2 treatment upregulated 30896796 115 Rat rno-miR-1 miRNA H2O2 myocardial infarction (MI) primary cultured rat?cardiomyocytes H2O2 treatment upregulated 31702064 116 Rat rno-miR-1 miRNA metoprolol myocardial infarction (MI) cardiomyocytes; heart tissues metoprolol treatment Pretreatment of metoprolol reversed these changes by decreasing miR-1 and increasing Cx43 expression. 31702064 117 Rat rno-miR-1 miRNA metoprolol myocardial infarction (MI) H2O2 treated primary cultured rat?cardiomyocytes Metoprolol treatment downregulated 31702064 118 Rat rno-miR-1 miRNA hypoxia myocardial ischaemic injury H9c2 cells hypoxia treatment downregulated 32030815 119 Rat rno-miR-1 miRNA sciatic nerve partial ligation peripheral nerve injury (PNI) dorsal root ganglion (DRG) sciatic nerve partial ligation therapy treatment downregulated in the injured nerve 27381812 120 Rat rno-miR-1 miRNA hypoxia pulmonary arterial hypertension (PAH) lung tissues hypoxia induce upregulated 29717493 121 Rat rno-miR-1 miRNA Su5416 pulmonary arterial hypertension (PAH) lung tissues Su5416 treatment upregulated 29717493 122 Rat rno-miR-1 miRNA exercise training (ET) pulmonary arterial stenosis (PAS) PAS rats PAS rats treatment miR-1 downregulated and miR-21 upregulation 27994552 123 Rat rno-miR-1 miRNA hypoxia/reoxygenation (H/R) pyroptosis H9c2 cells hypoxia/reoxygenation (H/R) treatment MiRNA-1 promoted pyroptosis of cardiomyocytes and release of inflammatory factors by downregulating the expression level of PIK3R1. 33215443 124 Rat rno-miR-1 miRNA aerobic exercise sinus bradycardia rats aerobic exercise training (AET) treatment upregulated 24825544 125 Rat rno-miR-1 miRNA perfluorooctane sulfonic acid (PFOS) perfluorooctane sulfonate (PFOS)-induced toxic action rat liver tissue dams received 3.2 mg/kg PFOS in their feed from gestational day 1 (GD1) to postnatal day 7 (PND 13) treatment different expression 24420840 126 Rat rno-miR-1 miRNA isoproterenol ¦Â-adrenoceptor intervention rat heart tissues isoproterenol (ISO) treatment downregulated 22847192 127 Rat rno-miR-10 miRNA scopolamine memory loss "prefrontal cortex (PFC), the hippocampus and the amygdala tissues" scopolamine treatment upregulated 31400468 128 Rat rno-miR-100 miRNA TGF-¦Â adaptation of tendons to mechanical loading rat Tendon fibroblasts Transforming growth factor-¦Â(TGF-¦Â) treatment upregulated 22539168 129 Rat rno-miR-100 miRNA isoproterenol cardiac hypertrophy H9c2 cells isoproterenol treatment miR-100 was upregulated during ISO- induced pathological hypertrophy. 29481791 130 Rat rno-miR-100 miRNA H2O2 glaucoma Rat RGC-5 cells H2O2 was added to induce oxidative stress treatment upregulated 25406880 131 Rat rno-miR-100 miRNA phosphodiesterase 5 (PDE5) inhibitor nonalcoholic fatty liver disease (NAFLD) plasma exosomes phosphodiesterase 5 (PDE5) inhibitor treatment upregulated 33396535 132 Rat rno-miR-100 miRNA hypoxia pulmonary hypertension (PH) pulmonary artery smooth muscle cells (PASMCs) hypoxia treatment downregulated 26409044 133 Rat rno-miR-100 miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) primary cultured microglia were extracted from 3-day-old neonatal rats lipopolysaccharide (LPS) treatment downregulated 31696457 134 Rat rno-miR-101 miRNA hypoxia/reoxygenation (H/R) autophagy H9c2 cardiomyocytes hypoxia/reoxygenation (H/R) treatment "the inhibition of miR-101 attenuated H/R-induced apoptosis, at least partially, via the induction of autophagy." 25606826 135 Rat rno-miR-101 miRNA hypoxia bladder fibrosis Bladder Smooth Muscle Cells hypoxia treatment Hypoxia could promote the expression of extracellular matrix subtypes and microRNA-101 in BSMCs. 30549198 136 Rat rno-miR-101 miRNA angiotensin II (Ang II) cardiac hypertrophy hypertrophic cardiac myocytes angiotensin II (Ang II) treatment downregulated 25850725 137 Rat rno-miR-101 miRNA chronic unpredictable mild stress (CUMS) depression rats ventrolateral orbital cortex (VLO) chronic unpredictable mild stress (CUMS) treatment downregulated in ventrolateral orbital cortex (VLO) 28549965 138 Rat rno-miR-101 miRNA hypoxia fibrosis bladder smooth muscle cells (BSMCs) hypoxia induce upregulated 30549198 139 Rat rno-miR-101 miRNA hypoxia myocardial infarction (MI) H9C2 cells hypoxia treatment downregulated 32072912 140 Rat rno-miR-101 miRNA lipopolysaccharide (LPS) neuropathic pain (NP) rat spinal microglia cells lipopolysaccharide (LPS) treatment downregulated 31526851 141 Rat rno-miR-101 miRNA lipopolysaccharide (LPS) neuropathic pain (NP) Rat spinal microglia cells lipopolysaccharide (LPS) treatment downregulated 31526851 142 Rat rno-miR-101 miRNA IL-1¦Â osteoarthritis (OA) Chondrocytes IL-1¦Â treatment The expression of Sox9 was likewise negatively regulated by miR-101 in rat chondrocytes 23227940 143 Rat rno-miR-101 miRNA salvianolic acid A (Sal A) spinal cord injury (SCI) RBMECs under hypoxia RBMECs under hypoxia treatment upregulation 28011395 144 Rat rno-miR-101-1 miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment upregulated 21094214 145 Rat rno-miR-101-3p miRNA complete freund's adjuvant (CFA) adjuvant-induced arthritis (AIA) Synovium and fibroblast-like synoviocytes (FLS) complete Freund¡¯s adjuvant treatment downregulated 29626254 146 Rat rno-miR-101-3p miRNA type II collagen rheumatoid arthritis (RA) synovial tissues type II collagen treatment miR-101-3p was highly expressed in synovial tissues of RA rats. 31894846 147 Rat rno-miR-101-3p miRNA zinc testicular ischemia-reperfusion injury (IRI) rat testicular tissue Zinc treatment downregulated 31692452 148 Rat rno-miR-101a miRNA infusion of oleic acid (OA) acute lung injury (ALI) lung tissues OA (200 ?l/kg) suspended in 20% ethyl alcohol was injected through the tail vein for 20 min treatment dysregulated 24736893 149 Rat rno-miR-101a miRNA hypoxia cerebral ischemia injury (CII) hypoxia-injured rat adrenal pheochromocytoma (PC-12) cells hypoxia induce "?lncRNA EFNA3 was highly expressed in response to hypoxia. Deletion of lncRNA EFNA3 significantly aggravated hypoxia-induced injury in PC-12 cells, as the impairment of cell viability, migration, and invasion, and the inducement of apoptosis. LncRNA EFNA3 worked as a sponging molecule for miR-101a and miR-101a suppression-protected PC-12 cells against hypoxia-induced injury even when lncRNA EFNA3 was silenced." 30125989 150 Rat rno-miR-101a miRNA mongolian medicine warm acupuncture insomnia rats brain tissues Mongolian medicine warm acupuncture treatment upregulated in the brain tissue 28672928 151 Rat rno-miR-101a miRNA oxygen glucose deprivation (OGD) ischemic brain injury Hippocampal neuronal oxygen-glucose deprivation (OGD) treatment upregulated 27074745 152 Rat rno-miR-101a miRNA H2O2 myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells H2O2 treatment MiR-101a was upregulated in H9c2 cell after H2O2 treatment. 32655807 153 Rat rno-miR-101a miRNA hypoxia cerebral ischemia injury (CII) PC-12 cells hypoxia treatment downregulated 30125989 154 Rat rno-miR-101a-3p miRNA pilocarpine epilepsy hippocampus tissues pilocarpine treatment MiR-101a-3p was downregulated while c-FOS was increased in hippocampus tissues of Rat model of pilocarpine-induced epilepsy 33559830 155 Rat rno-miR-101a-3p miRNA hypoxia/reoxygenation (H/R) ischemia/reperfusion (I/R) injury H9c2 cells hypoxia/reoxygenation (H/R) treatment upregulated 31746349 156 Rat rno-miR-101a-3p miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cell hypoxia induce upregulated 31746349 157 Rat rno-miR-101a-3p miRNA glucocorticoid (GC) respiratory distress syndrome lung Glucocorticoids treatment upregulated 26997989 158 Rat rno-miR-101b miRNA hypoxia cortical injury rat cortex tisssues hypoxia treatment downregulated 23272113 159 Rat rno-miR-101b miRNA TGF-¦Â1 diabetic nephropathy (DN) rat renal mesangial cells (MCs) Transforming growth factor-¦Â1 (TGF-¦Â) trreatment treatment upregulated 31266808 160 Rat rno-miR-101b miRNA oxygen glucose deprivation (OGD) ischemic brain injury Hippocampal neuronal oxygen-glucose deprivation (OGD) treatment upregulated 27074745 161 Rat rno-miR-101b miRNA WNT family of secreted lipoglycoproteins(Wnt-5a) Wnt-5a effect on hippocampal neurons primary hippocampal neurons of 18-day-old Sprague-Dawley rat embryos Wnt-5a treatment downregulated 26895946 162 Rat rno-miR-101b-3p miRNA monocrotaline (MCT) liver sinusoidal endothelial cells (LSEC) injury serum monocrotaline treatment upregulated 30019166 163 Rat rno-miR-101b-3p miRNA FK506 osteogenesis rat bone marrow stromal cells (BMSCs) FK506 treatment upregulated 28560399 164 Rat rno-miR-103 miRNA angiotensin II (Ang II) cardiac hypertrophy primary cultured myocardial cells from neonatal rats angiotensin II (Ang II) treatment downregulated 30604587 165 Rat rno-miR-103 miRNA 6-Gingerol (6-G) cerebral ischemia injury (CII) PC-12 cells 6-Gingerols (6G) treatment hypoxia administration upregulated miR-103 expression and 6G could further increase miR-103 expression in hypoxia-stimulated PC-12 cells. 31043087 166 Rat rno-miR-103 miRNA hypoxia cerebral ischemia injury (CII) rat PC-12 cells hypoxia induce upregulated 31043087 167 Rat rno-miR-103 miRNA repeated binge-EtOH exposure ethanol addiction dorsal and ventral hippocampus of male Wistar rats repeated binge-EtOH exposure treatment different regulation 24416161 168 Rat rno-miR-103 miRNA acetaminophen (APAP) liver damage plasma of rats acetaminophen (APAP) treatment miR-103 as suitable reference gene for plasma miRNAs analysis for acetaminophen-induced liver injury. 23558424 169 Rat rno-miR-103 miRNA ethanol (EtOH) liver regeneration rat liver tissue Chronic Ethanol Feeding treatment upregulated 22823254 170 Rat rno-miR-103 miRNA nerve growth factor (Ngf) neurodegenerative diseases PC12 cells 100 ng/ml Ngf treatment different regulation 24492999 171 Rat rno-miR-103 miRNA high fat diet (HFD) and streptozotocin (STZ) prediabetes state Peripheral blood mononuclear cells (PBMCs) high fat diet/streptozotocin (STZ) treatment upregulated 26164754 172 Rat rno-miR-103 miRNA zinc oxide nanoparticles (ZnONPs) and DPP-IV inhibitor (Vildagliptin) type 2 diabetes mellitus (T2DM) type 2 diabetes rats type 2 diabetes rats treatment downregulated 27723572 173 Rat rno-miR-103/107 miRNA hypoxia hypoxic pulmonary hypertension (HPH) PASMCs hypoxia treatment downregulated 26827991 174 Rat rno-miR-103a miRNA oxygen glucose deprivation (OGD) cerebral ischemia injury (CII) brain microvascular endothelial cells (BMECs) oxygen-glucose deprivation (OGD) treatment downregulated of microRNA-103a reduces microvascular endothelial cell injury in a rat model of cerebral ischemia by targeting AXIN2 31650542 175 Rat rno-miR-103a miRNA hypoxia cerebral ischemia injury (CII) brain microvascular endothelial cells (BMECs) middle cerebral artery occlusion (MCAO) induce upregulated 31650542 176 Rat rno-miR-103a miRNA lithium chloride and pilocarpine epilepsy hippocampus tissues of epilepsy rats lithium chloride-pilocarpine treatment upregulated 31049031 177 Rat rno-miR-106a miRNA tamoxifen (TAM) hepatocellular carcinoma (HCC) rat liver tamoxifen? treatment upregulated 17343880 178 Rat rno-miR-106b-5p miRNA lipopolysaccharide (LPS) cardiac dysfunction H9C2 cells lipopolysaccharide (LPS) treatment downregulated 33341669 179 Rat rno-miR-106b-5p miRNA matrine cardiac dysfunction LPS-treated H9C2 cells matrine treatment upregulated 33341669 180 Rat rno-miR-106b-5p miRNA matrine cardiac dysfunction H9c2 cells Matrine treatment upregulated 33341669 181 Rat rno-miR-106b-5p miRNA pentylenetetrazol (PTZ) epilepsy brain tissues pentylenetetrazol (PTZ) treatment upregulated 32779334 182 Rat rno-miR-106b-5p miRNA FK506 osteogenesis rat bone marrow stromal cells (BMSCs) FK506 treatment upregulated 28560399 183 Rat rno-miR-106b-5p miRNA matrine oxidative stress H9c2 cells matrine treatment Matrine modulated H2O2-induced myocardial oxidative stress repair through HOTAIR/miR-106b-5p axis via AKT and STAT3 signaling pathway. 32395744 184 Rat rno-miR-107 miRNA 6-hydroxydopamine (6-OHDA) Alzheimer's disease (AD) PC12 cells 6-hydroxydopamine (6-OHDA) treatment downregulated 31778666 185 Rat rno-miR-107 miRNA 6-hydroxydopamine (6-OHDA) Alzheimer's disease (AD) PC-12 cells 6-hydroxydopamine (6-OHDA) treatment 6-OHDA suppressed miR-107 expression. 31778666 186 Rat rno-miR-107 miRNA osthole Alzheimer's disease (AD) hippocampal and cortex region of the brain osthole treatment upregulated 27143098 187 Rat rno-miR-107 miRNA ketamine anesthesia-induced neural cytotoxicity rat brain embryonic stem cell (ESC)-derived neurons Ketamine treatment upregulated 30308117 188 Rat rno-miR-107 miRNA "2,4,6-trinitrobenzene sulfonic acid (TNBS)" colitis male Wistar rats inflamed colon "2,4,6-trinitrobenzene sulfonic acid (TNBS)/ethanol treatment" downregulated in inflamed colon 28572713 189 Rat rno-miR-107 miRNA ketamine ketamine-induced neurotoxicity rat brain embryonic stem cell (ESC)-derived neurons ketamine treatment "Ketamine induced apoptosis, neurite degeneration, and upregulated miR-107 in NSC-derived neurons." 30308117 190 Rat rno-miR-107 miRNA ethanol (EtOH) liver regeneration rat liver tissue Chronic Ethanol Feeding treatment upregulated 22823254 191 Rat rno-miR-107 miRNA penetrating ballistic-like brain injury penetrating ballistic-like brain injury (PBBI) male Sprague-Dawley rats brain tissue a unilateral frontal 10% PBBI treatment upregulated in brain tissue 28452880 192 Rat rno-miR-107 miRNA doxorubicin (DOX) renal interstitial fibrosis (RIF) kidneys doxorubicin (ADR) induction downregulated 32606425 193 Rat rno-miR-107 miRNA "kangxianling (KXL, anti-fibrin)" renal interstitial fibrosis (RIF) kidneys "Kangxianling (KXL, anti-fibrin) treatment" upregulated 32606425 194 Rat rno-miR-107-3p miRNA hypoxia hypoxic/ischemic injury Male Sprague Dawley rats "were exposed to hypoxia (9.5-10% O2) for 1, 5, or 10 days" upregulated 29262398 195 Rat rno-miR-107-5p miRNA hypoxia stroke middle cerebral artery occlusion (MCAO) Sprague-Dawley rat middle cerebral artery occlusion (MCAO) treatment upregulated 29113076 196 Rat rno-miR-10a miRNA retinoic acid receptor-¦Á (RAR¦Á)- and retinoid X receptor-¦Á (RXR¦Á)-specific agonists atherosclerosis (AS) inner curvature (OS region) of aortic arch in rats retinoic acid receptor-¦Á (RAR¦Á)- and retinoid X receptor-¦Á (RXR¦Á)-specific agonists dual treatment upregulated 29459264 197 Rat rno-miR-10a miRNA angiotensin II (Ang II) cardiac hypertrophy neonatal rat cardiomyocytes angiotensin II (Ang II) treatment upregulated 28100873 198 Rat rno-miR-10a miRNA streptozocin (STZ) diabetic retinopathy (DR) ?retinas?tissues streptozotocin (STZ) treatment downregulated 22156553 199 Rat rno-miR-10a miRNA verapamil male fertility testis verapamil treatment downregulated 32725937 200 Rat rno-miR-10a miRNA naringin renal ischemia/reperfusion (I/R) injury IR injury rat renal tissues naringin (NAR) treatment downregulated 30780111 201 Rat rno-miR-10a miRNA trimetazidine (TMZ) renal ischemia/reperfusion (I/R) injury IR injury rat renal tissues trimetazidine (TMZ) treatment downregulated 30780111 202 Rat rno-miR-10a miRNA pegylated rat leptin antagonist (pRLA) type 2 diabetes mellitus (T2DM) rat muscle and liver pegylated rat leptin antagonist (pRLA) treatment "upregulation of rno-miR-10a at d28 and rno-miR-200a, rno-miR-409-5p, and rno-miR-125a-3p following HFD challenge" 23576026 203 Rat rno-miR-10a miRNA "high concentrations of lipid and glucose, and cytokines" vascular hyper-reactivity VSMC "incubat high glucose (25mmol/L) or lipid (palmitic acid 50 ¦Ì mol/L) and 200ng/ml of TNF-¦Á,IL-1¦Â and IL-6 for 24h treatment" downregulated 25425000 204 Rat rno-miR-10a-5p miRNA acarbose diabetes mellitus (DM) blood acarbose? treatment upregulated 24260283 205 Rat rno-miR-10a-5p miRNA repeated binge-EtOH exposure ethanol addiction dorsal and ventral hippocampus of male Wistar rats repeated binge-EtOH exposure treatment different regulation 24416161 206 Rat rno-miR-10a-5p miRNA fluorine combined with aluminum (FA) fluorine combined with aluminum (FA)-induced developmental neurotoxicity hippocampi fluorine combined with aluminum (FA) treatment upregulated 30033483 207 Rat rno-miR-10a-5p miRNA hypoxia hypoxic/ischemic injury Male Sprague Dawley rats "were exposed to hypoxia (9.5-10% O2) for 1, 5, or 10 days" upregulated 29262398 208 Rat rno-miR-10a-5p miRNA fluorine combined with aluminum (FA) neurotoxicity hippocampi in the offspring of rats fluorine combined with aluminum (FA) exposure upregulated 30033483 209 Rat rno-miR-10a-5p miRNA steroids osteonecrosis of femoral head (ONFH) serum steroid treatment upregulated 29887962 210 Rat rno-miR-10b miRNA streptozocin (STZ) diabetic retinopathy (DR) ?retinas?tissues streptozotocin (STZ) treatment downregulated 22156553 211 Rat rno-miR-10b miRNA formaldehyde formaldehyde inducted immune/inflammation rats were exposed to formaldehyde treatment downregulated 24304932 212 Rat rno-miR-10b miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment upregulated 27910957 213 Rat rno-miR-10b miRNA ferulic acid (FA) oxidative stress PC-12 cells Ferulic Acid (FA) treatment "miR-10b was induced by H2O2 in PC12 cells, whereas FA inhibited H2O2-induced miR-10b." 33379243 214 Rat rno-miR-10b miRNA bisphenol S (BPS) pheochromocytoma (PCC) PC12 cells bisphenol S (BPS) treatment upregulated 30140998 215 Rat rno-miR-10b miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment downregulated 21094214 216 Rat rno-miR-10b-5p miRNA amyloid-¦Â (A¦Â) 1-42 Alzheimer's disease (AD) rat hippocampal tissues amyloid ¦Â1-42?(A¦Â) treatment "MiR-10b-5p was upregulated while HOXD10 was downregulated, and the Rho/ROCK signalling pathway was activated in hippocampal tissues of rats with AD." 33307856 217 Rat rno-miR-10b-5p miRNA anisakis complete extract (CE) anisakiasis sera anisakis complete extract (CE) treatment "mmu-miR-1b-5p and mmu-miR-10b-5p (a cancer-related miRNA) were significantly decreased (P?10-fold. In contrast, the expression levels of miR-192, 194, 215 and 375 were dramatically reduced (?0.32-fold) in adenocarcinomas." 19825969 565 Rat rno-miR-132 miRNA doxorubicin (DOX) dilated cardiomyopathy (DCM) heart tissues doxorubicin treatment downregulated 30216493 566 Rat rno-miR-132 miRNA testosterone heart angiogenesis heart tissue testosterone treatment upregulated 30907089 567 Rat rno-miR-132 miRNA H2O2 heart failure (HF) H9c2 cells H2O2 treatment downregulated 29682535 568 Rat rno-miR-132 miRNA luteolin hepatitis C virus (HCV) infection PC12 cells Luteolin treatment upregulated 22916239 569 Rat rno-miR-132 miRNA adreno-cortico-tropic-hormone (ACTH) hormonal regulation adrenals?tissues adreno-cortico-tropic-hormone (ACTH) treatment upregulated 24205079 570 Rat rno-miR-132 miRNA estradiol-17¦Â (E2) hormonal regulation adrenals?tissues estradiol-17¦Â (E2) treatment upregulated 24205079 571 Rat rno-miR-132 miRNA angiotensin II (Ang II) hypertension heart tissues angiotensin II (Ang II) treatment upregulated 23712358 572 Rat rno-miR-132 miRNA oxygen glucose deprivation (OGD) hypoxic/ischemic brain damage (HIBD) fetal rat hippocampal neurons oxygen-glucose deprivation (OGD) treatment upregulated 28627974 573 Rat rno-miR-132 miRNA oxygen glucose deprivation (OGD) ischemic brain injury Hippocampal neuronal oxygen-glucose deprivation (OGD) treatment upregulated 27074745 574 Rat rno-miR-132 miRNA propofol (PPF) learning and memory deficits neonatal rats hippocampus propofol treatment downregulated in the hippocampus 28109866 575 Rat rno-miR-132 miRNA enoxacin major depressive disorder (MDD) rats with 10 or 25 mg/kg enoxacin for 1 week treatment upregulated 24575053 576 Rat rno-miR-132 miRNA hypoxia myocardial infarction (MI) cardiomyocyte The left anterior descending branch of LCA was ligated. downregulated 31621911 577 Rat rno-miR-132 miRNA oxygen glucose deprivation (OGD) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells oxygen-glucose deprivation (OGD) treatment upregulated 31210352 578 Rat rno-miR-132 miRNA oxygen glucose deprivation (OGD) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells oxygen glucose deprivation (OGD) treatment OGD disposition obviously enhanced miR-132 expression in H9c2 cells. 31210352 579 Rat rno-miR-132 miRNA hypoxia nerve injury Schwann cells (SCs) after peripheral nerve injury Hypoxia treatment upregulated 26399639 580 Rat rno-miR-132 miRNA dexmedetomidine (DEX) neuroinflammation "adult Wistar rats brain ,plasma," dexmedetomidine (Dex) treatment downregulated 28832497 581 Rat rno-miR-132 miRNA high fat diet (HFD) neuroinflammation hippocampus high fat diet (HFD) feed downregulated 30134248 582 Rat rno-miR-132 miRNA lipopolysaccharide (LPS) neuroinflammation adult Wistar rats brain regions lipopolysaccharide (LPS) treatment upregulated in both brain regions 28832497 583 Rat rno-miR-132 miRNA dexamethasone (DEX) neuronal function cortical neurons dexamethasone (DEX) treatment downregulated 19958814 584 Rat rno-miR-132 miRNA physical EE neuropsychiatric disorders hippocampal physical EE treatment upregulated 26132842 585 Rat rno-miR-132 miRNA polychlorinated biphenyls (PCBs) neuropsychological disorders postnatal day 1¨C2 (P1¨CP2) Sprague¨CDawley rats hippocampal cultures nanomolar concentrations of PCB 95 treatment upregulated 24431430 586 Rat rno-miR-132 miRNA high fat diet (HFD) obesity rats high fat diet (HFD) feed dysregulated 24517225 587 Rat rno-miR-132 miRNA glucagon-like peptide-1 (GLP-1) pancreatic ¦Â-cell dysfunction INS-1 832/3 cells glucagon-like peptide 1 (GLP-1) treatment upregulated 26218441 588 Rat rno-miR-132 miRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) lung and pulmonary arterial tissues monocrotaline treatment upregulated 30896881 589 Rat rno-miR-132 miRNA IL-6 and TNF-¦Á rheumatoid arthritis (RA) Schwann cells 0.1 ng/mL IL-6 and 20 ng/mL TNF-¦Á treatment downregulated 30456455 590 Rat rno-miR-132 miRNA sciatic nerve partial ligation nerve regeneration dorsal root ganglion (DRG) sciatic nerve partial ligation therapy treatment upregulation 26399639 591 Rat rno-miR-132 miRNA lipopolysaccharide (LPS) sepsis-induced lung injury rat alveolar macrophage cell line NR8383 lipopolysaccharide (LPS) treatment upregulated 26052826 592 Rat rno-miR-132 miRNA sevoflurane (SEV) sevoflurane-induced neuronal apoptosis brain tissues sevoflurane treatment miRNA-132 was downregulated in sevoflurane-induced rats 30272258 593 Rat rno-miR-132 miRNA aluminum (Al) spatial learning and memory impairment offspring rats hippocampus exposure to aluminium during the embryonic stage upregulated 30172012 594 Rat rno-miR-132 miRNA fluoride spatial learning and memory impairment offspring rats hippocampus exposure to fluorine during the embryonic stage upregulated 30172012 595 Rat rno-miR-132 miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC-12 cells lipopolysaccharide (LPS) treatment downregulated 30691440 596 Rat rno-miR-132 miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC-12 cell lipopolysaccharide (LPS) treatment downregulated 31062615 597 Rat rno-miR-132 miRNA notoginsenoside R1 (NGR1) spinal cord injury (SCI) LPS-treated PC-12 cell notoginsenoside R1 (NGR1) treatment upregulated 31062615 598 Rat rno-miR-132 miRNA resveratrol spinal cord injury (SCI) LPS-treated PC-12 cells resveratrol (RSV) treatment upregulated 30691440 599 Rat rno-miR-132 miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment upregulated 21094214 600 Rat rno-miR-132 miRNA lithium chloride (LiCl) temporal lobe epilepsy (TLE) Temporal lobe? tissues TGF-¦Â treatment upregulated 24995086 601 Rat rno-miR-132 miRNA cilostazol vascular smooth muscle cell (VSMC) differentiation vascular smooth muscle cell (VSMC) cilostazol treatment Treatment of cultured rat VSMCs with cilostazol resulted in the upregulated of PTEN mRNA and the downregulated of miR-132. 29738818 602 Rat rno-miR-132 miRNA brain-derived neurotrophic factor (BDNF) neuronal function cortical neurons brain-derived neurotrophic factor (BDNF) treatment upregulated 19958814 603 Rat rno-miR-132-3p miRNA angiostrongylus cantonensis (A. cantonensis) inflammation healthy male SD rats angiostrongylus cantonensis (A. cantonensis) infection upregulated 24142286 604 Rat rno-miR-132-3p miRNA N-methyl-D-aspartate receptor long-term potentiation (LTP) persistence rat dentate gyrus rat dentate gyrus 20 min post-LTP induction in vivo treatment downregulated 25538559 605 Rat rno-miR-132-3p miRNA di(2-ethylhexyl) phthalate (DEHP) neurotoxicity female Long Evans rats hippocampal di(2-ethylhexyl) phthalate (DEHP) treatment upregulated 28192093 606 Rat rno-miR-132-3p miRNA di(2-ethylhexyl) phthalate (DEHP) neurotoxicity male Long Evans rats hippocampal di(2-ethylhexyl) phthalate (DEHP) treatment downregulated 28192093 607 Rat rno-miR-132-3p miRNA high fat diet (HFD) nonalcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD) feed upregulated 31915454 608 Rat rno-miR-132-3p miRNA Shenling Baizhu San (SLBZS) nonalcoholic fatty liver disease (NAFLD) liver tissues Shenling Baizhu San (SLBZS) treatment the expression levels were reversed by SLBZS administration 31915454 609 Rat rno-miR-132-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 610 Rat rno-miR-132-3p miRNA methylprednisolone steroid-induced osteonecrosis of femoral head (ONFH) bone microvascular endothelial cells (BMECs) methylprednisolone treatment upregulated 29408208 611 Rat rno-miR-132-5p miRNA nicotine neuroprotective effects PC12 cells nicotine treatment miR-132-5p was increased upon nicotine treatment. 32174265 612 Rat rno-miR-132-5p miRNA di(2-ethylhexyl) phthalate (DEHP) neurotoxicity female Long Evans rats hippocampal di(2-ethylhexyl) phthalate (DEHP) treatment upregulated 28192093 613 Rat rno-miR-132-5p miRNA di(2-ethylhexyl) phthalate (DEHP) neurotoxicity male Long Evans rats hippocampal di(2-ethylhexyl) phthalate (DEHP) treatment downregulated 28192093 614 Rat rno-miR-132-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 615 Rat rno-miR-132-5p miRNA herb-partitioned moxibustion ulcerative colitis (UC) UC rats colon tissues herb-partitioned moxibustion downregulated 28246536 616 Rat rno-miR-133 miRNA ovalbumin (OVA) asthma lung tissues ovalbumin (OVA) treatment downregulated 29938673 617 Rat rno-miR-133 miRNA human growth hormone (hGH) cardiac hypertrophy ventricular muscle recombinant human growth hormone (r-hGH) treatment upregulated 30842884 618 Rat rno-miR-133 miRNA human growth hormone (hGH) cardiac hypertrophy heart tissues swimming exercise plus r-hGH treatment upregulated 30842884 619 Rat rno-miR-133 miRNA swimming cardiac hypertrophy ventricular muscle swimming induce treatment upregulated 30842884 620 Rat rno-miR-133 miRNA swimming cardiac hypertrophy heart tissues The exercise groups completed a 1-h swimming exercise 5 times a week for 8 weeks. treatment upregulated 30842884 621 Rat rno-miR-133 miRNA thyroid hormone cardiac hypertrophy Cardiomyocytes thyroid hormone (TH) treatment downregulated 26202011 622 Rat rno-miR-133 miRNA streptozocin (STZ) diabetic nephropathy (DN) renal tissue streptozotocin (STZ) treatment upregulated 31858564 623 Rat rno-miR-133 miRNA ivabradine electrophysiological cardiac remodelling heart of rat ?ivabradine treatment upregulated 21838751 624 Rat rno-miR-133 miRNA tanshinone IIA (Tan IIA) H2O2-induced cell death H9c2 cells tanshinone IIA treatment downregulated 27446335 625 Rat rno-miR-133 miRNA aloe-emodin (AE) myocardial infarction (MI) H2O2-treated neonatal rat ventricular myocytes (NRVMs) aloe-emodin (AE) treatment upregulated 31207343 626 Rat rno-miR-133 miRNA H2O2 myocardial infarction (MI) neonatal rat ventricular myocytes (NRVMs) H2O2 treatment downregulated 31207343 627 Rat rno-miR-133 miRNA oxygen glucose deprivation (OGD) myocardial infarction (MI) H9c2 cells Oxygen-glucose deprivation (OGD) treatment circMAT2B knockdown works as an inflammatory inhibitor in OGD-induced H9c2 cells inflammatory injury through up-regulating miR-133 32897801 628 Rat rno-miR-133 miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) treatment The expression of miR-133 was significantly decreased in H/R-treated H9c2 cells. 32685535 629 Rat rno-miR-133 miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) treatment downregulated 32685535 630 Rat rno-miR-133 miRNA doxorubicin (DOX) oxidative stress rat heart cell H9c2 doxorubicin (DOX) treatment downregulated 28867607 631 Rat rno-miR-133 miRNA H2O2 oxidative stress rat heart cell H9c2 H2O2 treatment downregulated 28867607 632 Rat rno-miR-133 miRNA tanshinone IIA (Tan IIA) oxidative stress rat heart cell H9c2 treated by either H2O2 or doxorubicin (DOX) Tanshinone ¢òA treatment upregulated 28867607 633 Rat rno-miR-133a miRNA doxycycline atrial fibrillation (AF) heart tissues doxycycline treatment downregulated 30470910 634 Rat rno-miR-133a miRNA doxycycline atrial fibrillation (AF) heart sissues doxycycline treatment upregulated 30470910 635 Rat rno-miR-133a miRNA TGF-¦Â1 bladder outlet obstruction (BOO) bladder smooth muscle cells (BSMCs) TGF-¦Â1 treatment downregulated 25451078 636 Rat rno-miR-133a miRNA "3,5-diiodo-L-thyronine (T2)" browning of white adipocytes subcutaneous white adipose tissue (sWAT) receiving a high fat diet for 10 weeks and being subsequently treated for four weeks with an HFD together with the administration of T? downregulated 30889829 637 Rat rno-miR-133a miRNA high fat diet (HFD) browning of white adipocytes subcutaneous white adipose tissue (sWAT) high fat diet (HFD) feed upregulated 30889829 638 Rat rno-miR-133a miRNA norepinephrine (NE) cardiac hypertrophy neonatal rat ventricular cardiomyocytes norepinephrine treatment downregulated 28795305 639 Rat rno-miR-133a miRNA phenanthrene (Phe) cardiac hypertrophy H9C2 cells phenanthrene (Phe) treatment downregulated 26830171 640 Rat rno-miR-133a miRNA ischemia cardiomyocyte apoptosis cardiomyocytes Ischemic postconditioning (IPost)treatment upregulated 21406115 641 Rat rno-miR-133a miRNA daunorubicin cardiomyopathy rats "daunorubicin (DAU-A, 3 mg/kg, every 48 h)" downregulated 28303410 642 Rat rno-miR-133a miRNA acute and long-term aerobic exercise cardiorespiratory fitness young men acute and long-term aerobic exercise treatment downregulated 27895662 643 Rat rno-miR-133a miRNA isoproterenol and doxorubicin cardiotoxicity rats plasma isoproterenol and doxorubicin treatment upregulated after treatment with doxorubicin 25092230 644 Rat rno-miR-133a miRNA dexamethasone (DEX) glucocorticoid-induced osteoporosis (GIOP) mesenchymal stem cells (MSCs) dexamethasone (DEX) treatment qRT-PCR analysis indicated that glucocorticoid induced high miR-133a expression in MSCs and animal models. 33781345 645 Rat rno-miR-133a miRNA losartan ischemia/reperfusion (I/R) injury heart tissues losartan treatment upregulated 26168042 646 Rat rno-miR-133a miRNA hypoxia myocardial hypoxia injury H9c2 cells hypoxia treatment downregulated 25421410 647 Rat rno-miR-133a miRNA hydrogen sulfide (H2S) myocardial ischemia/reperfusion (I/R) injury (MIRI) I/R-induced H9c2 cells hydrogen sulfide (H2S) treatment upregulated 30326468 648 Rat rno-miR-133a miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia induce downregulated 30326468 649 Rat rno-miR-133a miRNA hydrogen sulfide (H2S) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hydrogen sulfide (H2S) treatment miR-133a expression levels were significantly lower than those in the control group. 30326468 650 Rat rno-miR-133a miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells hypoxia/reoxygenation (H/R) induce downregulated 31734557 651 Rat rno-miR-133a miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 652 Rat rno-miR-133a miRNA 1-methyl-4-phenylpyridinium (MPP+) parkinson's disease (PD) PC-12 cells MPP+ (1-methyl-4-phenylpyridinium) treatment Low miR-133a expression was detected in a cell model of MPP?-induced PD. 32713934 653 Rat rno-miR-133a miRNA epigallocatechin-3-gallate (EGCG) prostatic hyperplasia (BPH) prostatic hyperplasia (BPH) rats prostate tissue Epigallocatechin-3-gallate (EGCG) treatment upregulated 30179845 654 Rat rno-miR-133a miRNA testosterone prostatic hyperplasia (BPH) Prostate tissue testosterone treatment downregulated 30179845 655 Rat rno-miR-133a miRNA estrogen (ES) pulmonary arterial hypertension (PAH) "PAH rats blood vessels, rat pulmonary smooth muscle cell (RPASMC)" estrogen (ES) treatment upregulated 31562386 656 Rat rno-miR-133a miRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) blood vessels monocrotaline (MCT) treatment downregulated 31562386 657 Rat rno-miR-133a miRNA quinone compounds P3H4 renal cell carcinoma (RCC) renal cancer tissue P3H4 treatment miR-133a was significantly upregulated in rat renal cancer tissue after the treatment of P3H4 30178839 658 Rat rno-miR-133a miRNA berberine (BBR) vascular dementia in diabetes diabetic rats vascular endothelium berberine (BBR) treatment downregulated 30472896 659 Rat rno-miR-133a miRNA berberine (BBR) vascular dementia in diabetes diabetic rats vascular endothelium berberine (BBR) treatment downregulated 30472896 660 Rat rno-miR-133a miRNA streptozocin (STZ) vascular dementia in diabetes vascular endothelium streptozotocin (STZ) treatment upregulated 30472896 661 Rat rno-miR-133a miRNA streptozocin (STZ) vascular dementia in diabetes vascular endothelium streptozotocin treatment upregulated 30472896 662 Rat rno-miR-133a3p miRNA muscle contraction diabetes mellitus (DM) muscle tissues "stimulated to contract in vitro for twitch tension analysis (0.5 Hz), 30 min later for tetanic analysis (100 Hz)" upregulated 28000044 663 Rat rno-miR-133a-3p miRNA pentoxifylline (PTX) cardiac injury heart sissues Pentoxifylline (PTX) treatment Pentoxifylline (PTX) treatment produced a dose-dependent increase in miRNA-133a-3p expressions 31972363 664 Rat rno-miR-133a-3p miRNA ioversol contrast-induced nephropathy (CIN) kidney tissues ioversol treatment downregulated 33387208 665 Rat rno-miR-133a-3p miRNA H2O2 coronary artery disease (CAD) H9c2 cells H2O2 treatment Lower miR-133a-3p level was found in H2O2-induced H9c2 cells. 32764884 666 Rat rno-miR-133a-3p miRNA methamphetamine (METH) methamphetamine (METH) addiction brain tissues Methamphetamine (METH) treatment downregulated 32893733 667 Rat rno-miR-133a-3p miRNA electrode cardiac fibrosis atrium tissues of rats electrode stimulation downregulated 32130618 668 Rat rno-miR-133a-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 669 Rat rno-miR-133a-3p miRNA notexin skeletal muscle atrophy plasma notexin treatment upregulated 26952641 670 Rat rno-miR-133a-5p miRNA methamphetamine (METH) drug addiction heart tissues Methamphetamine treatment downregulated 31825931 671 Rat rno-miR-133a-5p miRNA Rhynchophylline drug addiction methamphetamine-treated rats heart tissues Rhynchophylline treatment upregulated 31825931 672 Rat rno-miR-133a-5p miRNA Rhynchophylline drug addiction heart sissues Rhynchophylline treatment Rhynchophylline could significantly increase the expression of miR-133a-5p 31825931 673 Rat rno-miR-133a-5p miRNA ischemia hepatic ischemia/reperfusion injury (HIRI) liver tissues ischemia for 1 h and reperfusion for 2 h downregulated 28198596 674 Rat rno-miR-133a-5p miRNA propofol (PPF) hepatic ischemia/reperfusion injury (HIRI) Sprague-Dawley rats liver (I/R) injury rats treatment upregulated 28198596 675 Rat rno-miR-133a-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 676 Rat rno-miR-133b miRNA Sodium iodate (NaIO3) retinal injury eyes tissues Sodium iodate (NaIO3) treatment upregulated 23143922 677 Rat rno-miR-133b miRNA TGF-¦Â1 bladder outlet obstruction (BOO) bladder smooth muscle cells (BSMCs) TGF-¦Â1 treatment downregulated 25451078 678 Rat rno-miR-133b miRNA vitamin D receptor activators (VDRAs) chronic renal failure (CRF) nephrectomized Wistar rats equivalent doses of two VDRAs: calcitriol and paricalcitol treatment upregulated 28460073 679 Rat rno-miR-133b miRNA caffeic acid diabetic nephropathy (DN) high-fat diet and streptozotocin-induced (HFD-STZ) diabetic rats caffeic acid (CA) treatment downregulated 28536471 680 Rat rno-miR-133b miRNA morphine dopaminergic (DA) neuron differentiation mature rat hippocampal neurons Morphine treatment downregulated 20716624 681 Rat rno-miR-133b miRNA hypoxia hypoxia-induced injury H9c2 cell hypoxia induce downregulated of miR-133b aggravated the cell injury induced by hypoxia. 31885905 682 Rat rno-miR-133b miRNA losartan ischemia/reperfusion (I/R) injury heart tissues losartan treatment upregulated 26168042 683 Rat rno-miR-133b miRNA epigallocatechin-3-gallate (EGCG) prostatic hyperplasia (BPH) prostatic hyperplasia (BPH) rats prostate tissue Epigallocatechin-3-gallate (EGCG) treatment upregulated 30179845 684 Rat rno-miR-133b miRNA testosterone prostatic hyperplasia (BPH) Prostate tissue testosterone treatment downregulated 30179845 685 Rat rno-miR-133b miRNA high inorganic phosphate (Pi) vascular calcification (VC) vascular smooth muscle high-phosphorous treatment downregulated 26187577 686 Rat rno-miR-133b miRNA high inorganic phosphate (Pi) vascular calcification (VC) vascular smooth muscle high-phosphorous treatment lower levels of miR-133b and miR-211 and higher levels of miR-29b 26187577 687 Rat rno-miR-133b-3p miRNA muscle contraction diabetes mellitus (DM) muscle tissues "stimulated to contract in vitro for twitch tension analysis (0.5 Hz), 30 min later for tetanic analysis (100 Hz)" upregulated 28000044 688 Rat rno-miR-133b-3p miRNA cannabinoid receptor type II (CB2R) parkinson's disease (PD) PC12 cells cannabinoid receptor type II (CB2R) treatment CB2 receptor agonist AM1241 alleviated PD via regulation of the Xist/miR-133b-3p/Pitx3 axis. 31989652 689 Rat rno-miR-133b-3p miRNA notexin skeletal muscle atrophy plasma notexin treatment upregulated 26952641 690 Rat rno-miR-133b-5p miRNA morphine cardiomyocytes against H/R injury H9c2 cells morphine treatment upregulated 26919791 691 Rat rno-miR-133b-5p miRNA hypoxia HPC-induced cardioprotection rat cardiomyocytes hypoxia preconditioning (HPC) treatment upregulated 29568969 692 Rat rno-miR-133b-5p miRNA hypoxia/reoxygenation (H/R) HPC-induced cardioprotection rat cardiomyocytes hypoxia/reoxygenation (H/R) treatment downregulated 29568969 693 Rat rno-miR-133b-5p miRNA morphine hypoxia/reoxygenation (H/R) injury cardiomyocytes morphine treatment "After H/R injury, the decrease in miR-133b-5p and a contemporaneous rise in Fas mRNA and protein levels in adult rat cardiomyocytes were prevented by MPC treatment." 26919791 694 Rat rno-miR-133b-5p miRNA doxorubicin (DOX) ischemia/reperfusion (I/R) injury rats cardiomyocytes doxorubicin treatment downregulated 27919821 695 Rat rno-miR-133b-5p miRNA human immunodeficiency virus (HIV)-1 gp120 V3 Loop peptide neuron apoptosis cortical neurons HIV-1 gp120 V3 Loop peptide treatment upregulated 26280272 696 Rat rno-miR-133b-5p miRNA human immunodeficiency virus (HIV)-1 neuronal cell dysfunction and apoptosis primary rat cortical neurons HIV-1 treatment upregulated 26280272 697 Rat rno-miR-133c miRNA methamphetamine (METH) methamphetamine (METH) addiction brain tissues Methamphetamine (METH) treatment downregulated 32893733 698 Rat rno-mir-133c miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 699 Rat rno-miR-134 miRNA CoCl2 autophagy PC12 cells CoCl2 treatment downregulated 33410125 700 Rat rno-miR-134 miRNA propofol (PPF) autophagy CoCl2-treated PC12 cells propofol treatment upregulated 33410125 701 Rat rno-miR-134 miRNA soluble ¦Â-amyloid (sA¦Â) oligomers Alzheimer's disease (AD) cortical neurons were isolated from E17 embryos of Sprague Dawley rats sA¦Â treatment upregulated 24595404 702 Rat rno-miR-134 miRNA adeno-associated virus (AAV) cerebral ischemia injury (CII) neuron death induced by OGD/reoxygenation adeno-associated virus (AAV) Doxorubicin (DOX) upregulated 25316150 703 Rat rno-miR-134 miRNA resveratrol cognitive impairment primary cultured hippocampus neurons resveratrol (RS) treatment downregulated 29715537 704 Rat rno-miR-134 miRNA chronic unpredictable mild stress (CUMS) depression hippocampal tissues chronic unpredictable mild stress (CUMS) treatment upregulated 30716615 705 Rat rno-miR-134 miRNA enriched environment (EE) depression Chronic unpredictable mild stress (CUMS) treated rat hippocampal tissues Enriched environment (EE) treatment downregulated 30716615 706 Rat rno-miR-134 miRNA ginsenoside Rg1 depression basolateral amygdala (BLA) Ginsenoside Rg1 treatment upregulated 30121663 707 Rat rno-miR-134 miRNA unpredictable chronic mild stress (UCMS) depression ventromedial prefrontal cortex (vmPFC) unpredictable chronic mild stress (UCMS) induce treatment upregulated 29329879 708 Rat rno-miR-134 miRNA kainic acid (KA) epilepsy brain tissue and serum kainic acid treatment downregulated 29917202 709 Rat rno-miR-134 miRNA kainic acid (KA) epilepsy hippocampus tissue kainic acid (KA) treatment upregulated 31031600 710 Rat rno-miR-134 miRNA ethylene glycol monomethyl ether (EGME) hyperglycemia ?testicle of rat Ethylene glycol monomethyl ether (EGME) treatment "miR-449a and miR-92a decreased obviously and, miR-320, miR-134 and miR-188 increased" 22008535 711 Rat rno-miR-134 miRNA brain-derived neurotrophic factor (BDNF) hypoxic/ischemic brain damage (HIBD) rats hippocampalwith hypoxic-hypoglycemic neuron injury brain-derived neurotrophic factor (BDNF) treatment downregulated 28343294 712 Rat rno-miR-134 miRNA freund¡¯s complete adjuvant (FCA) Insulin resistance and nonalcoholic steatohepatitis (NASH) rat dorsal root ganglia (DRG) Freund's adjuvant (CFA) treatment downregulated of miR-134 and upregulated of MOR1 22865422 713 Rat rno-miR-134 miRNA electroacupuncture (EA) ischemic stroke (IS) middle cerebral artery occlusion induced cognitive deficit (MICD) rats hippocampal electroacupuncture (EA) treatment downregulated 28116173 714 Rat rno-miR-134 miRNA bile duct ligation (BDL) liver fibrosis liver tissues bile duct ligation (BDL) treatment downregulated 30645141 715 Rat rno-miR-134 miRNA carbon tetrachloride (CCl4) liver fibrosis liver tissues carbon tetrachloride (CCl4) treatment downregulated 30645141 716 Rat rno-miR-134 miRNA dimethylnitrosamine (DMN) liver fibrosis liver tissues dimethylnitrosamine (DMN) treatment downregulated 30645141 717 Rat rno-miR-134 miRNA TGF-¦Â1 liver fibrosis The rat hepatic stellate cell line HSC-T6 TGF-¦Â1 treatment downregulated 30645141 718 Rat rno-miR-134 miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells hypoxia/reoxygenation (H/R) induce upregulated 31618402 719 Rat rno-miR-134 miRNA dexmedetomidine (DEX) neuroinflammation "adult Wistar rats brain ,plasma," dexmedetomidine (Dex) treatment downregulated 28832497 720 Rat rno-miR-134 miRNA lipopolysaccharide (LPS) neuroinflammation adult Wistar rats brain regions lipopolysaccharide (LPS) treatment upregulated in both brain regions 28832497 721 Rat rno-miR-134 miRNA H2O2 neuron survival retinal ganglion cell (RGC) H2O2 treatment upregulated 25744098 722 Rat rno-miR-134 miRNA magnesium (Mg2+ ) neuroprotective effects hippocampus of the SE rats low Mg2+-exposed upregulated 28942448 723 Rat rno-miR-134 miRNA propofol (PPF) neuroprotective effects primary hippocampal neurons under OGD condition propofol treatment downregulated 26884981 724 Rat rno-miR-134 miRNA paliperidone neurotoxicity SH-SY5Y cells SH-SY5Y cells treatment downregulated 26055227 725 Rat rno-miR-134 miRNA magnesium (Mg2+ ) satus epilepticus (SE) rat hippocampal neurons low Mg2+ treatment upregulated 24810882 726 Rat rno-miR-134 miRNA Safflor yellow B (SYB) stroke cortical cells Safflor yellow B (SYB) treatment Safflor Yellow B Attenuates Ischemic Brain Injury via downregulated of Long Noncoding AK046177 and Inhibition of MicroRNA-134 Expression in Rats 32566081 727 Rat rno-miR-134 miRNA "fenoldopam, dopamine and midodrine" vascular injury rat mesentery cells "Fenoldopam, dopamine and midodrine treatment" upregulated 22627061 728 Rat rno-miR-134-5p miRNA H2O2 acute myocardial infarction (AMI) H9c2 cells H2O2 treatment H2O2-induced cardiomyocyte injury upregulated miR-134-5p expression. 32689640 729 Rat rno-miR-134-5p miRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia treatment Hypoxia-induced cardiomyocyte injury upregulated miR-134-5p expression. 32689640 730 Rat rno-miR-134-5p miRNA amyloid-¦Â (A¦Â) 1-42 Alzheimer's disease (AD) hippocampus tissues amyloid ¦Â1-42?(A¦Â) treatment upregulated 31625272 731 Rat rno-miR-134-5p miRNA amyloid-¦Â (A¦Â) 1-42 Alzheimer's disease (AD) hippocampus amyloid ¦Â1-42?(A¦Â) treatment upregulated 31625272 732 Rat rno-miR-134-5p miRNA potentiates inorganic phosphate (Pi) calcium deposition A10 cells potentiates inorganic phosphate (Pi) treatment upregulated 32783377 733 Rat rno-miR-134-5p miRNA ¦Ä-opioid receptor (DOR) hypoxic/ischemic injury hearts ¦Ä-opioid receptor (DOR) activation treatment upregulated 27576463 734 Rat rno-miR-134-5p miRNA oxygen glucose deprivation (OGD) hypoxic/ischemic brain damage (HIBD) PC-12 cells oxygen glucose deprivation (OGD) treatment The expression of miR-134-5p was elevated in PC12 cells following OGD. 32814091 735 Rat rno-miR-134-5p miRNA X-rays large intestine cancer SW620 cells; HT29 cells X-ray radiation treatment LncRNA TTN-AS1/miR-134-5p/PAK3 axis regulates the radiosensitivity of human large intestine cancer cells through the P21 pathway and AKT/GSK-3¦Â/¦Â-catenin pathway 32749739 736 Rat rno-miR-134-5p miRNA permanent bilateral common carotid artery occlusion (2VO) vascular dementia (VD) brain cortex tissues Permanent bilateral occlusion of the common carotid artery (2-VO) induce treatment upregulated 31545395 737 Rat rno-miR-135a miRNA cerulein acute pancreatitis (AP) AR42J cells cerulein treatment upregulated 31729558 738 Rat rno-miR-135a miRNA schisandrin B (Sch B) asthma lung Schisandrin B treatment upregulated 26916957 739 Rat rno-miR-135a miRNA Streptococcus pneumoniae (Sp) bacterial meningitis (BM) astrocytes Streptococcus pneumoniae?infection treatment downregulated 30726113 740 Rat rno-miR-135a miRNA astragaloside IV (AS-IV) cardiac fibrosis heart tissues astragaloside IV (AS-IV) treatment upregulated 31739105 741 Rat rno-miR-135a miRNA isoproterenol cardiac fibrosis cardiac fibroblasts (CFs) isoprenaline (ISO) tteatment downregulated 29775892 742 Rat rno-miR-135a miRNA hypoxia cerebral ischemia/reperfusion (I/R) injury Primary rat cerebral cortical neurons hypoxia induce downregulated 29719095 743 Rat rno-miR-135a miRNA pilocarpine epilepsy adult male rats brain tissue and heart tissue 50 days of pilocarpine treatment downregulated in the brain tissue 24530830 744 Rat rno-miR-135a miRNA ¦Ä-opioid receptor (DOR) hypoxic/ischemic injury hearts ¦Ä-opioid receptor (DOR) activation treatment upregulated 27576463 745 Rat rno-miR-135a miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia induce downregulated 30644128 746 Rat rno-miR-135a miRNA "hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)" neurotoxicity brain tissues of rats RDX at a dose(47 mg/kg) for 48 h treatment upregulated 25559034 747 Rat rno-miR-135a miRNA H2O2 oxidative stress rat cardiomyoblast cells H9c2 H2O2 upregulated 28123342 748 Rat rno-miR-135a miRNA stress post-traumatic stress disorder (PTSD) Wistar rats HIP controlled lighting (light on 07:00¨C19:00 hr) and temperature (25 ¡À 2¡ãC) conditions with ad libitum access to food and water treatment upregulated 28944448 749 Rat rno-miR-135a miRNA "paroxetine hydrochloride and corticotropin-releasing factor antagonist (CP-154,526)" post-traumatic stress disorder (PTSD) PTSD Wistar rats HIP "CP-154,526 treatment" downregulated 28944448 750 Rat rno-miR-135a miRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) lung tissues monocrotaline (MCT) treatment upregulated 31773709 751 Rat rno-miR-135a miRNA acute stress (AS) and chronic stress (CS) stress-induced myocardial injury rat Rats were bound and suspended treatment downregulated 24669248 752 Rat rno-miR-135a-5p miRNA kainic acid (KA) epilepsy primary hippocampal neuron kainic acid (KA) treatment "lncRNA GAS5 functions as a competitive endogenous RNA of miR-135a-5p to increase expression of KCNQ3, and lncRNA GAS5 silencing inhibited the occurrence and progression of epilepsy." 31373759 753 Rat rno-miR-135a-5p miRNA magnesium-free extracellular fluid epilepsy primary hippocampal neurons from newborn rats magnesium-free medium culture upregulated 31091851 754 Rat rno-miR-135a-5p miRNA magnesium-free extracellular fluid epilepsy primary hippocampal neuron magnesium-free extracellular fluid culture "lncRNA GAS5 functions as a competitive endogenous RNA of miR-135a-5p to increase expression of KCNQ3, and lncRNA GAS5 silencing inhibited the occurrence and progression of epilepsy." 31373759 755 Rat rno-miR-135a-5p miRNA hypoxia ischemic stroke (IS) PC12 cells hypoxia induce downregulated 31632583 756 Rat rno-miR-135a-5p miRNA hypoxia pulmonary arterial hypertension (PAH) pulmonary artery smooth muscle cells (PASMCs) hypoxia induce downregulated 30038339 757 Rat rno-miR-135a-5p miRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) lung tissues monocrotaline (MCT) treatment downregulated 30038339 758 Rat rno-miR-135a-5p miRNA H2O2 spinal cord injury (SCI) PC-12 cells H2O2 treatment downregulated 33294293 759 Rat rno-miR-135a-5p miRNA Jianpi Xiaoke (JPXK) type 2 diabetes mellitus (T2DM) rat Jianpi Xiaoke (JPXK) treatment downregulated 33456489 760 Rat rno-miR-135b miRNA radiation breast cancer rat mammary cancer tissues radiation treatment upregulated 23273170 761 Rat rno-miR-135b miRNA 1-methyl-4-phenylpyridinium (MPP+) parkinson's disease (PD) rat PC-12 cells 1-methyl-4-phenylpyridinium (MPP+) treatment downregulated 31036506 762 Rat rno-miR-135b-5p miRNA hypoxia hypoxic/ischemic injury Male Sprague Dawley rats "were exposed to hypoxia (9.5-10% O2) for 1, 5, or 10 days" upregulated 29262398 763 Rat rno-miR-136 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment upregulated 27910957 764 Rat rno-miR-136-3p miRNA amyloid-¦Â (A¦Â) 1-42 Alzheimer's disease (AD) hippocampus amyloid ¦Â1-42?(A¦Â) treatment downregulated 29706607 765 Rat rno-miR-136-3p miRNA high fat diet (HFD) and injection of pituitrin coronary artery disease (CAD) myocardial tissues high-fat diet and injection of pituitrin downregulated 32434208 766 Rat rno-miR-136-3p miRNA homocysteine (Hcy) coronary artery disease (CAD) cardiac microvascular endothelial cells (CMECs) homocysteine (HCY) treatmemt downregulated 32434208 767 Rat rno-miR-136-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) PC-12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 30546117 768 Rat rno-miR-136-5p miRNA sulfasalazine multiple sclerosis (MS) OLN-93 cells sulfasalazine (SF) treatment SF downregulated lncRNA HOTAIR but upregulated miR-136-5p 29944870 769 Rat rno-miR-136-5p miRNA electroacupuncture (EA) spinal cord injury (SCI) spinal cords electroacupuncture (EA) treatment downregulated 32468009 770 Rat rno-miR-137 miRNA ethanol (EtOH) alcohol exposure amygdala tissues Adolescent rats were exposed to 2 g/kg ethanol (2 d on/off; AIE) or adolescent intermittent saline (AIS) during postnatal days (PND)28-PND41 and allowed to grow to adulthood. upregulated 31740576 771 Rat rno-miR-137 miRNA hypoxia apoptosis GC-5 cells; HEK-293 cells "5% O2, 90% N2 and 5% CO2," downregulated 29286063 772 Rat rno-miR-137 miRNA hypoxia apoptosis The rat retinal ganglion cell line RGC-5 hypoxia induce downregulated 29286063 773 Rat rno-miR-137 miRNA propofol (PPF) cell apoptosis and autophagy PC-12 cells Propofol treatment upregulated 31678238 774 Rat rno-miR-137 miRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissues streptozocin (STZ) treatment downregulated 28695984 775 Rat rno-miR-137 miRNA triptolide (TPL) diabetic nephropathy (DN) the kidney tissues of the diabetic rats triptolide (TPL) treatment upregulated 28695984 776 Rat rno-miR-137 miRNA ketamine hippocampal neurodegeneration hippocampal neurons administrat ketamine (75 mg/kg) for 3 days treatment downregulated 25197371 777 Rat rno-miR-137 miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic injury rat hippocampal neurons oxygen-glucose deprivation and reoxygenation (OGD/R) treatment miR-137 expression reduced in hippocampal neurons after OGD treatment. 31961204 778 Rat rno-miR-137 miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) neural ischemia/reperfusion (I/R) injury hippocampal neurons isolated from neonatal Sprague-Dawley rats oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 28132879 779 Rat rno-miR-137 miRNA chronic constriction injury (CCI) neuropathic pain (NP) rats chronic constriction injury (CCI) induce downregulated 29115665 780 Rat rno-miR-137 miRNA heme oxygenase-1 (HMOX1) oxidative stress primary spinal cord neurons of E16 rat embryos HO-1 upregulated 27864650 781 Rat rno-miR-137 miRNA lead (Pb) spatial memory impairment hippocampal tissues developmental lead (Pb) exposure upregulated 31511494 782 Rat rno-miR-137 miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC12 cells lipopolysaccharide (LPS) treatment miR-137 effectively inhibited the apoptosis of LPS-challenged PC12 cells 33499717 783 Rat rno-miR-137-5p miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) primary microglia were isolated from the spinal cord of newborn rats lipopolysaccharide (LPS) treatment downregulated 31210303 784 Rat rno-miR-138 miRNA hypoxia ischemic heart disease (IHD) H9c2 cells hypoxia induce "miR-138 was a downstream effector of lncRNA-LET, that miR-138 was highly expressed in lncRNA-LET-overexpressed cell. The cardioprotective effects of lncRNA-LET were abolished when miR-138 was silenced." 31222827 785 Rat rno-miR-138 miRNA hypoxia psoriasis H9C2 cells hypoxia treatment upregulated 24211202 786 Rat rno-miR-138 miRNA IL-6 and lipopolysaccharide (LPS) advanced periodontal disease periodontal ligament (PDL) cells IL-6 and lipopolysaccharide (LPS) treatment upregulated 26518300 787 Rat rno-miR-138 miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia/reperfusion (I/R) injury hippocampus primary neurons oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 29614311 788 Rat rno-miR-138 miRNA high glucose (HG) diabetic cardiomyopathy (DCM) AC16 cardiomyocytes high glucose (HG) treatment GAS5 expression was upregulated in HG-treated AC16 cardiomyocytes and the rat diabetic myocardial injury model 33682891 789 Rat rno-miR-138 miRNA estradiol-17¦Â (E2) hormonal regulation adrenals?tissues estradiol-17¦Â (E2) treatment downregulated 24205079 790 Rat rno-miR-138 miRNA hyperoside hypoxia-induced cardiac dysfunctions H9C2 cells Hyperoside (Hyp) treatment The expression levels of miR-138 were increased in the hypoxic myocardium in the presence of Hyp 33649812 791 Rat rno-miR-138 miRNA astragalus polysaccharide (APS) hypoxia-induced injury hypoxia-induced neural stem cells (NSCs) astragalus polysaccharide (APS) treatment upregulated 29567543 792 Rat rno-miR-138 miRNA hypoxia hypoxia-induced injury neural stem cells (NSCs) hypoxia induce upregulated 29567543 793 Rat rno-miR-138 miRNA hypoxia ischemic heart disease (IHD) H9c2 cells hypoxia treatment upregulated 31222827 794 Rat rno-miR-138 miRNA emodin myocardial infarction (MI) hypoxia-induced H9c2 cells emodin treatment upregulated 30810622 795 Rat rno-miR-138 miRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia induce downregulated 30810622 796 Rat rno-miR-138 miRNA lipopolysaccharide (LPS) myocarditis H9c2 cells lipopolysaccharide (LPS) treatment downregulated 31442445 797 Rat rno-miR-138-5p miRNA hypoxia/reoxygenation (H/R) acute myocardial infarction (AMI) H9c2 cells hypoxia/reoxygenation (H/R) treatment MiR-138-5p was downregulated in H/R-induced H9C2 cells. 33219594 798 Rat rno-miR-138-5p miRNA metformin (Met) acute respiratory distress syndrome (ARDS) NR8383 cells metformin treatment downregulated 30178862 799 Rat rno-miR-138-5p miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2cells hypoxia/reoxygenation (H/R) treatment downregulated 32231469 800 Rat rno-miR-138-5p miRNA gan-jiang-ling-zhu decoction (GJLZ) nonalcoholic fatty liver disease (NAFLD) liver tissues Gan-Jiang-Ling-Zhu decoction (GJLZ) treatment "MiR-138?5p expression was significantly increased in the model group, and GJLZ decoction downregulated the expression." 32325349 801 Rat rno-miR-138-5p miRNA MgSO4 osteogenesis rat primary bone marrow stromal cells MgSO4 treatment downregulated 31081160 802 Rat rno-miR-138-5p miRNA insulin-like growth factor 1 (IGF-1) spinal cord injury (SCI) Neural stem cells were obtained from E15 fetal rat cerebral cortex cultured supernatant exosomes insulin growth factor-1 (IFG-1) treatment upregulated 31848325 803 Rat rno-miR-139 miRNA monomethyl fumarate (MF) intracerebral haemorrhage (ICH) intracerebral hemorrhage (ICH) rat brain tissues Monomethyl fumarate (MF) treatment upregulated 31210338 804 Rat rno-miR-139-3p miRNA acute eccentric exercise exercise-induced muscle damage (EIMD) Sprague-Dawley (SD) rats a downhill running treatment at -16? gradient dysregulated 28638919 805 Rat rno-miR-139-5p miRNA hypoxic/ischemic neuron apoptosis neurons;rat brain tissues hypoxia-ischemia treatment downregulated 24333693 806 Rat rno-miR-139-5p miRNA liraglutide antiapoptotic INS-1 cells liraglutide (100 nM) for 48 h downregulated 28346520 807 Rat rno-miR-139-5p miRNA spontaneous recurrent epileptiform discharges (SREDs) epilepsy rat primary hippocampal neurons spontaneous recurrent epileptiform discharges (SREDs) treatment miR-139-5p upregulation alleviated SREDs-induced oxidative stress and cell apoptosis via regulating the Notch pathway 33247610 808 Rat rno-miR-139-5p miRNA phenylephrine (PE) refractory epilepsy hippocampus phenobarbitone injection treatment microRNA-139-5p confers sensitivity to antiepileptic drugs in refractory epilepsy by inhibition of MRP1 31750616 809 Rat rno-miR-139-5p miRNA fluid-percussion injury (FPI) traumatic brain injury (TBI) Sprague-Dawley rats FPI downregulated 28273100 810 Rat rno-miR-139-5-p miRNA H2O2 cardiomyocytes injury H9c2 cells H2O2 treatment downregulated 26884911 811 Rat rno-miR-139b miRNA "high concentrations of lipid and glucose, and cytokines" vascular hyper-reactivity VSMC "incubat high glucose (25mmol/L) or lipid (palmitic acid 50 ¦Ì mol/L) and 200ng/ml of TNF-¦Á,IL-1¦Â and IL-6 for 25h treatment" downregulated 25425000 812 Rat rno-miR-1-3p miRNA isoproterenol acute cardiac injury heart tissues isoproterenol treatment upregulated 27605421 813 Rat rno-miR-1-3p miRNA insert a cannula connected with a saline container into the anterior chamber acute ocular hypertension (AOH) adult albino rats retinal ganglion cells (RGCs) and microglial cells insert a cannula connected with a saline container into the anterior chamber downregulated 27535721 814 Rat rno-miR-1-3p miRNA muscle contraction diabetes mellitus (DM) muscle tissues "stimulated to contract in vitro for twitch tension analysis (0.5 Hz), 30 min later for tetanic analysis (100 Hz)" upregulated 28000044 815 Rat rno-miR-1-3p miRNA butorphanol ischemic arrhythmias myocardial tissues butorphanol treatment Butorphanol significantly reduced the level of miR-1-3p in myocardium. 33210593 816 Rat rno-miR-1-3p miRNA notexin skeletal muscle atrophy plasma notexin treatment upregulated 26952641 817 Rat rno-miR-1-3p miRNA Jianpi Xiaoke (JPXK) type 2 diabetes mellitus (T2DM) rat Jianpi Xiaoke (JPXK) treatment upregulated 33456489 818 Rat rno-miR-140 miRNA paclitaxel (PTX) lung fibrosis lung tisssue of rats paclitaxel? treatment low-dose PTX prevents pulmonary fibrosis by suppressing the TGF-¦Â1/Smad3 pathway via upregulating miR-140 23967091 819 Rat rno-miR-140 miRNA lipopolysaccharide (LPS) acute lung injury (ALI) plasma and lungs lipopolysaccharide (LPS) treatment downregulated 30233718 820 Rat rno-miR-140 miRNA food restriction malnutrition rats serum 10 days of 40% food restriction (RES) treatment downregulated 24456162 821 Rat rno-miR-140 miRNA ormeloxifene ormeloxifene-induced inhibition of embryo implantation uterine tissues ormeloxifene treatment miR-140 expression was found to be elevated in ormeloxifene administered groups. 29330027 822 Rat rno-miR-140 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment upregulated 27910957 823 Rat rno-miR-140 miRNA atorvastatin pericardial patch angioplasty patch isolated from surrounding vascular tissue atorvastatin treatment upregulated 30662650 824 Rat rno-miR-140* miRNA aflatoxin B1 (AFB1) hepatocellular carcinoma (HCC) 7-week-old Fischer344 male rats liver aflatoxin B1 (AFB6) treatment upregulated 24472605 825 Rat rno-miR-140* miRNA nicotine nicotine addiction rat PC12 cell nicotine treatment upregulated 18845019 826 Rat rno-miR-140-3p miRNA fetal bovine serum (FBS) liver fibrosis HSC-T6 cells Cells were incubated with 5% FBS for 48 h upregulated 31124340 827 Rat rno-miR-140-3p miRNA platelet derived growth factor-BB (PDGF-BB) liver fibrosis HSC-T6 cells Cells were treated with 10 ng/mL of PDGF-BB for 48 h treatment upregulated 31124340 828 Rat rno-miR-140-3p miRNA TGF-¦Â1 liver fibrosis HSC-T6 cells TGF-¦Â2 treatment upregulated 31124340 829 Rat rno-miR-140-5p miRNA shikonin acute lung injury (ALI) rat lung tissues Shikonin treatment Shikonin has effective treatment effects on acute lung injury via regulation of microRNA-140-5p/toll-like receptor 4 (miRNA-140-5p/TLR4) in the in vivo study 31769066 830 Rat rno-miR-140-5p miRNA doxorubicin (DOX) doxorubicin (DOX)-induced cardiotoxicity H9c2 cells doxorubicin (DOX) treatment upregulated 29304479 831 Rat rno-miR-140-5p miRNA dioscin doxorubicin (DOX)-induced cardiotoxicity H9c2 cells dioscin treatment downregulated 29524841 832 Rat rno-miR-140-5p miRNA dexmedetomidine (DEX) hypoxic/ischemic brain damage (HIBD) Hypoxia-ischaemia (HI)-treated neonatal rats?brain tissues dexamethasone (DEX) treatment upregulated 29536658 833 Rat rno-miR-140-5p miRNA doxorubicin (DOX) cardiomyocytes injury SD rats heart tissue treat with DOX upregulated 29304479 834 Rat rno-miR-140-5p miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) treatment The expression of miR-140-5p in H/R-induced H9c2 cells was higher than that in the control group. 32572928 835 Rat rno-miR-140-5p miRNA hypoxia pulmonary arterial hypertension (PAH) rats pulmonary artery smooth muscle cells (PASMCs) hypoxia induce downregulated 30367500 836 Rat rno-miR-140-5p miRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) lung tissues monocrotaline (MCT) treatment downregulated 30367500 837 Rat rno-miR-141 miRNA paraquat (PQ) lung injury lung tissues; RLE-6TN cells paraquat (PQ) treatment downregulated 33015978 838 Rat rno-miR-141 miRNA thalidomide lung injury lung tissues; RLE-6TN cells thalidomide treatment upregulated 33015978 839 Rat rno-miR-141 miRNA glucose fluctuations (GF) cardiovascular complications of diabetes mellitus (DM) heart glucose fluctuations (GF) treatment upregulated 26497329 840 Rat rno-miR-141 miRNA N-acetyl-L-cysteine (NAC) chronic nonbacterial prostatitis (CNP) carrageenan-induced CNP rats N-acetyl-L-cysteine (NAC) treatment upregulation 26941030 841 Rat rno-miR-141 miRNA antibiotics dysbacteria Sprague Dawley (SD) rats faeces treat with a combination of antibiotics for 8 week downregulated 29264965 842 Rat rno-miR-141 miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment downregulated 27041227 843 Rat rno-miR-141 miRNA hypoxia hypoxia-induced injury PC12 cells hypoxia induce downregulated 31273531 844 Rat rno-miR-141 miRNA cisplatin (DDP) kidney damage male Wistar rats cisplatin treatment upregulated 24880025 845 Rat rno-miR-141 miRNA TGF-¦Â1 liver fibrosis HSC-T6 cells TGF-¦Â1 treatment downregulated of miR-141 deactivates hepatic stellate cells by targeting the PTEN/AKT/mTOR pathway 32319536 846 Rat rno-miR-141 miRNA chronic constriction injury (CCI) neuropathic pain (NP) dorsal root ganglion chronic constriction injury (CCI) treatment downregulated 26398163 847 Rat rno-miR-141 miRNA ochratoxin A (OTA) ochratoxin A (OTA) nephrotoxicity kidney?tissues OTA nephrotoxicity treatment suppressed in mid dose but then elevated in high dose 24885635 848 Rat rno-miR-141 miRNA 1-methyl-4-phenylpyridinium (MPP+) parkinson's disease (PD) PC12 cells N-methyl-4-phenylpyridinium (MPP +) treatment "MPP+ toxicity significantly caused upregulated in miR-34a, miR-141, and miR-9." 29631008 849 Rat rno-miR-141 miRNA lipopolysaccharide (LPS) rheumatoid arthritis (RA) chondrocyte lipopolysaccharide (LPS) treatment "miR-141 was upregulated in LPS-treated chondrocyte. Inhibitory effects of MEG3 overexpression, mentioned above, were partially abolished by overexpressed miR-141." 31411001 850 Rat rno-miR-141 miRNA dexamethasone (DEX) steroid-induced avascular necrosis of femoral head (SANFH) Bone marrow mesenchymal stem cells (BMSC) dexamethasone (DEX) treatment The mRNA expression of miR-141 was higher in the DEX group compared with the control group. 31916393 851 Rat rno-miR-141 miRNA acute stress (AS) and chronic stress (CS) stress-induced myocardial injury rat Rats were bound and suspended treatment upregulated 24669248 852 Rat rno-miR-141-3p miRNA particulate matter (PM2.5) allergic rhinitis (AR) nasal mucosa particulate matter 2.5 (PM2.5) treatment downregulated 32192351 853 Rat rno-miR-141-3p miRNA high fat diet (HFD) cardiac dysfunction myocardium high fat diet (HFD) feed upregulated 32346302 854 Rat rno-miR-141-3p miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) treatment H/R remarkably reduces the expression of miR-141-3p. 32123560 855 Rat rno-miR-141-3p miRNA propofol (PPF) neurodegeneration (ND) rats neural stem cells (NSCs) propofol treatment upregulated 27796156 856 Rat rno-miR-141-3p miRNA propofol (PPF) neurodegenerative diseases neural stem cells (NSCs) propofol treatment upregulated 27796156 857 Rat rno-miR-141-3p miRNA hypoxia oxidative stress H9c2 rat cardiomyoblasts hypoxia induce upregulated 31532760 858 Rat rno-miR-141-3p miRNA 1-methyl-4-phenylpyridinium (MPP+) parkinson's disease (PD) PC-12 cells MPP+ (1-methyl-4-phenylpyridinium) treatment miR-141-3p was upregulated in MPP+-treated PC12 cells. 33204711 859 Rat rno-miR-141-3p miRNA letrozole polycystic ovarian syndrome (PCOS) Ovary?tissues letrozole treatment dysregulated 26745201 860 Rat rno-miR-141-3p miRNA phthalate mixture prostate development Pregnant females filial generation rat prostate Pregnant females were divided into 4 groups and orally dosed daily from GD10 to PND21 with corn oil (Control:C) or the phthalate mixture at three doses (20?¦Ìg/kg/d:T1; 200?¦Ìg/kg/d:T2; 200?mg/kg/d:T3). treatment upregulated 31199487 861 Rat rno-miR-141-3p miRNA bleomycin (BLM) lung fibrosis rat lung tissues bleomycin (BLM) treatment downregulated 30755599 862 Rat rno-miR-141-3p miRNA TGF-¦Â1 lung fibrosis RLE-6TN cells TGF-¦Â1 treatment downregulated 30755599 863 Rat rno-miR-141-3p miRNA high glucose (HG) pyroptosis H9c2 cells high glucose (HG) treatment "MALAT1 mRNA expression levels were significantly increased, whereas miR-141-3p expression levels were significantly decreased in HG-treated H9C2 cells compared with the NG group." 33576445 864 Rat rno-miR-142 miRNA electroacupuncture (EA) hyperactivity of the HPA axis induced by hepatectomy rats electroacupuncture (EA) treatment upregulated 29021740 865 Rat rno-miR-142 miRNA hepatectomy hyperactivity of the HPA axis induced by hepatectomy rats hypothalamic hepatectomy downregulated 29021740 866 Rat rno-miR-142-3p miRNA TGF-¦Â3 blood-testis barrier (BTB) impairment Primary Sertoli cell TGF-¦Â3 treatment downregulated 29590647 867 Rat rno-miR-142-3p miRNA angiotensin II (Ang II) cardiac hypertrophy cultured neonatal rat cardiomyocytes angiotensin II (Ang II) treatment downregulated 30372837 868 Rat rno-miR-142-3p miRNA citrate cardiomyocyte autophagy cardiomyocytes citrate treatment "The level of miR-142-3p was downregulated in H/R model, but upregulated in cardiomyocytes following citrate treatment." 32456513 869 Rat rno-miR-142-3p miRNA isoproterenol drug-induced cardiac injury (DICI) heart tissues isoproterenol treatment upregulated 29355689 870 Rat rno-miR-142-3p miRNA TGF-¦Â liver cirrhosis rat primary HSCs TGF-¦Â treatment downregulated 28823564 871 Rat rno-miR-142-3p miRNA hypoxia/reoxygenation (H/R) ischemia/reperfusion (I/R) injury mesenchymal stem cell (MSC) exosome hypoxia-reoxygenation (H/R) treatment upregulated 32719674 872 Rat rno-miR-142-3p miRNA phosphodiesterase 5 (PDE5) inhibitor nonalcoholic fatty liver disease (NAFLD) plasma exosomes phosphodiesterase 5 (PDE5) inhibitor treatment upregulated 33396535 873 Rat rno-miR-142-3p miRNA FK506 osteogenesis rat bone marrow stromal cells (BMSCs) FK506 treatment upregulated 28560399 874 Rat rno-miR-142-3p miRNA X-rays radiosensitivity 786-O and A549 cells 786-O and A549 cells treatment dysregulated 27527863 875 Rat rno-miR-142-3p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) reperfusion/ischemia brain injury Primary cortical neurons oxygen-glucose deprivation and reoxygenation (OGD/R) treatment miR-142-3p expression was downregulated in neurons when exposed to oxygen-glucose deprivation/re-oxygenation. 32246643 876 Rat rno-miR-142-3p miRNA lipopolysaccharide (LPS) sepsis-induced acute kidney injury rat mesangial cells (RMCs) lipopolysaccharide (LPS) treatment upregulated 30834562 877 Rat rno-miR-142-5p miRNA acute stressor modulates acute stress male Fisher 344 rats expose to an acute stressor modulates treatment downregulated 25259839 878 Rat rno-miR-142-5p miRNA oleanolic acid (OLA) diabetic nephropathy (DN) high glucose-induced NRK-52E cells oleanolic acid (OLA) treatment downregulated 31410746 879 Rat rno-miR-142-5p miRNA streptozocin (STZ) diabetic retinopathy (DR) retinal tissues streptozocin (STZ) treatment miR-142-5p level was downregulated in retinal tissues of DR rats. 32116075 880 Rat rno-miR-142-5p miRNA hypoxia heart failure (HF) H9c2 cells hypoxia induce "silence of lncRNA GAS5 attenuated hypoxia-triggered cell death, silence of lncRNA GAS5 protected H9c2 cells against hypoxia-induced injury possibly via sponging miR-142-5p." 31085811 881 Rat rno-miR-142-5p miRNA Smad3 inhibitor (SIS3) intrauterine adhesion (IUA) endometrial stromal cells (ESCs) Smad3 inhibitor (SIS3) treatment upregulated 32447720 882 Rat rno-miR-142-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemia/reperfusion (I/R) injury rat hippocampal neurons oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 28320085 883 Rat rno-miR-142-5p miRNA hypoxia ischemic heart disease (IHD) H9C2 cardiomyoblasts hypoxia treatment downregulated 28772218 884 Rat rno-miR-142-5p miRNA IL-6 osteogenesis bone marrow stromal stem cells (BMSCs) IL-6 treatment "BLACAT1 expression was increased in inflammatory BMSCs, and knockdown of BLACAT1 promoted proliferation and osteogenic differentiation of BMSCs targeting miR-142-5p." 32271407 885 Rat rno-miR-142-5p miRNA triclosan (TCS) testosterone R2C cells; testis; Leydig cells Triclosan (TCS) treatment "TCS treatment upregulated miR-142-5p expressions in Leydig cells, with the maximum inductive effect observed in R2C cells treated with 10 ¦ÌM of TCS" 32084696 886 Rat rno-miR-143 miRNA plum polyphenols aberrant crypt foci colon tissues plum polyphenols treatment upregulated 27865352 887 Rat rno-miR-143 miRNA "2,4,6-trinitrobenzene sulfonic acid (TNBS)" colitis male Wistar rats inflamed colon "2,4,6-trinitrobenzene sulfonic acid (TNBS)/ethanol treatment" downregulated in inflamed colon 28572713 888 Rat rno-miR-143 miRNA doxorubicin (DOX) doxorubicin (DOX)-induced cardiotoxicity H9c2 cells doxorubicin (Dox) treatment Doxorubicin treatment increased the expression of miR-143. 32170053 889 Rat rno-miR-143 miRNA stimulation electrode epilepsy Adult male Sprague Dawley rats blood A bipolar stimulation electrode (distance between tips 500 ?m) was implanted in the angular bundle treatment dysregulated 24184920 890 Rat rno-miR-143 miRNA myocardin hepatitis C virus (HCV) infection rat primary aortic SMCs myocardin treatment myocardin coordinate smooth muscle differentiation by inducing transcription of microRNA-143 20489207 891 Rat rno-miR-143 miRNA activin A insulin action in cardiomyocytes primary adult rat cardiomyocytes (ARC) activin A treatment downregulated 23812417 892 Rat rno-miR-143 miRNA aerobic exercise left ventricular hypertrophy (LVH) left ventricular aerobic exercise training (AET) treatment downregulated 21709209 893 Rat rno-miR-143 miRNA trichostatin A (TSA) hepatocellular carcinoma (HCC) rat primary hepatocytes Trichostatin A (TSA)treatment treatment "miR-122, miR-143 and miR-379 could be related to the inhibitory effects of TSA on hepatocellular proliferation" 21513791 894 Rat rno-miR-143 miRNA hypoxia myocardial infarction (MI) neonatal rat cardiomyocytes hypoxia induce upregulated 30998966 895 Rat rno-miR-143 miRNA hypoxia/reoxygenation (H/R) myocardial infarction (MI) cardiomyocytes hypoxia/reoxygenation (H/R) treatment lncUCA1 might protect cardiomyocyte against H/R induced apoptosis by suppressing miR-143 and modulated the following downstream MDM2/p53 signaling pathway. 30998966 896 Rat rno-miR-143 miRNA high fat diet (HFD) obesity adipose tissues high fat diet (HFD) feed "The obese rats in the HFD group, compared with rats in the NFD group, demonstrated a significant decrease in the expression of miR-27a (p < 0.05) and a significant increase in the expression of miR-143." 30411548 897 Rat rno-miR-143 miRNA hypoxia pulmonary arterial hypertension (PAH) lung tissues hypoxia treatment upregulated 30195228 898 Rat rno-miR-143 miRNA single dose irradiation radiation-induced lung injury (RILI) male Wistar rats lung tissues subjected to single dose irradiation with 20 Gy using 6 MV x-rays to the right lung treatment upregulated 24886372 899 Rat rno-miR-143 miRNA zinc oxide nanoparticles (ZnONPs) and DPP-IV inhibitor (Vildagliptin) type 2 diabetes mellitus (T2DM) type 2 diabetes rats type 2 diabetes rats treatment downregulated 27723572 900 Rat rno-miR-143 miRNA high fat diet (HFD) weight gain end epididymal fat high fat diet (HFD) feed upregulated 29023027 901 Rat rno-miR-143-3p miRNA atorvastatin cardiac fibrosis cardiac fibroblasts (CFs) atorvastatin treatment Atorvastatin suppressed the levels of miR-143-3p. 31758917 902 Rat rno-miR-143-3p miRNA TGF-¦Â1 cardiac fibrosis cultured?cardiac fibroblasts (CFs) TGF-¦Â1 upregulated 31758917 903 Rat rno-miR-143-3p miRNA ¦Â3-adrenoceptors(¦Â3-AR) inhibitor SR 59230A chronic heart failure (CHF) CHF rats 1 ml SR 59230A(85 mmoL/L in 0.9% saline)twice a day for seven weeks by intraperitoneal injection treatment upregulated 29926593 904 Rat rno-miR-143-3p miRNA cisplatin and gentamicin drug-induced acute kidney injury (DIKI) plasma "cisplatin (CSP, 6?mg/kg) and gentamicin (GEN, 120?mg/kg) treatment" downregulated 30682439 905 Rat rno-miR-143-3p miRNA gypenoside A (GP) ischemia/reperfusion (I/R) injury H9c2 cells Gypenoside A (GP) treatment Administration of GP decresed the expression of miR-143-3p. 31889343 906 Rat rno-miR-143-3p miRNA angiotensin II (Ang II) left ventricular hypertrophy (LVH) H9c2 cells angiotensin II (Ang II) treatment upregulated 30119211 907 Rat rno-miR-143-3p miRNA atorvastatin left ventricular hypertrophy (LVH) angiotensin II (Ang II)-treated H9c2 cells atorvastatin treatment downregulated 30119211 908 Rat rno-miR-143-3p miRNA H2O2 cardiac hypertrophy H9c2 cells H2O2 treatment H2O2 administration increased the levels of miR-143-3p. 30203887 909 Rat rno-miR-143-3p miRNA gypenoside A (GP) myocardial ischemia/reperfusion (I/R) injury (MIRI) hypoxia-induced H9c2 cell line Gypenoside A (GP) treatment downregulated 31889343 910 Rat rno-miR-143-3p miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cell line hypoxia induce upregulated 31889343 911 Rat rno-miR-143-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 912 Rat rno-miR-143-5p miRNA propofol (PPF) neurotoxicity primary cultured neural stem cells (NSCs) propofol treatment upregulated 29679758 913 Rat rno-miR-144 miRNA ginsenoside Rg1 apoptosis hypoxia-induced PC12 cells Ginsenoside Rg1 treatment downregulated 30262824 914 Rat rno-miR-144 miRNA hypoxia apoptosis PC12 cells OGD/R treatment upregulated 30262824 915 Rat rno-miR-144 miRNA isoprenaline cardiac hypertrophy rat primary cardiomyocytes isoprenaline induction downregulated 33013286 916 Rat rno-miR-144 miRNA hypoxia cardioprotective therapy bone marrow mesenchymal stem cell (MSC)-derived exosomes hypoxia treatment upregulated 31973741 917 Rat rno-miR-144 miRNA human immunodeficiency virus (HIV)-1 chronic human immunodeficiency virus (HIV) infection alveolar epithelial cell (AEC) Human immunodeficiency virus (HIV)-1 infection upregulated 31091144 918 Rat rno-miR-144 miRNA high glucose (HG) diabetic cardiomyopathy (DCM) H9c2 cells; Neonatal rat cardiomyocytes (NRCMs) high glucose (HG) treatment downregulated 31907983 919 Rat rno-miR-144 miRNA streptozocin (STZ) diabetic retinopathy (DR) ?retinas?tissues streptozotocin (STZ) treatment downregulated 22156553 920 Rat rno-miR-144 miRNA high glucose (HG) hyperglycemia-induced cardiac dysfunction "Neonatal rat cardiomyocytes (NRCMs), rat H9c2 cells" high glucose treatment downregulated 31907983 921 Rat rno-miR-144 miRNA ginsenoside Rg1 ischemia/reperfusion (I/R) injury OGD/R-treated PC-12 cell Ginsenoside Rg1 (Rg1) treatment downregulated 30262824 922 Rat rno-miR-144 miRNA hypoxia ischemia/reperfusion (I/R) injury PC-12 cells oxygen-glucose deprivation/reperfusion (OGD/R) treatment upregulated 30262824 923 Rat rno-miR-144 miRNA swimming left ventricular hypertrophy (LVH) rat left ventricular Swimming exercise training treatment upregulated 23812090 924 Rat rno-miR-144 miRNA SiO2 lung injury lung SiO2 treatment upregulated 27689473 925 Rat rno-miR-144 miRNA 4-vinylcyclohexene diepoxide (VCD) premature ovarian failure (POF) ovarian 4-vinylcyclohexene diepoxide (VCD) tretament downregulated 24188450 926 Rat rno-miR-144 miRNA botulinum neurotoxin (BoNT) nerve sprouting spinal cord anterior horn botulinum neurotoxin (BoNT) treatment downregulated 32083076 927 Rat rno-miR-144 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment upregulated 27910957 928 Rat rno-miR-144 miRNA 4-vinylcyclohexene diepoxide (VCD) premature ovarian failure (POF) rat POF tissues VCD treatment downregulated 24188450 929 Rat rno-miR-144 miRNA american ginseng root's premature ovarian failure (POF) 4-Vinylcyclohexene diepoxide (VCD) treatment upregulated 25705687 930 Rat rno-miR-144-3p miRNA high fat diet (HFD) cardiac dysfunction myocardium high fat diet (HFD) feed upregulated 32346302 931 Rat rno-miR-144-3p miRNA rapamycin cardiac fibrosis heart tissues rapamycin (Rap) treatment downregulated 30647817 932 Rat rno-miR-144-3p miRNA iohexol contrast-induced acute kidney injury (CIAKI) Renal tissue "Animals were dehydrated for 48 h and then underwent furosemide (10 mL/kg; Harvest Pharmaceutical, Shanghai, China) injection 30 min before administration of iohexol (15 mL/kg, group CI-AKI; iodine, 350 mg/mL; GE Healthcare, Shanghai, China) or 0.9% normal saline (15 mL/kg, control group)." miR-144-3p was downregulated in Contrast-induced acute kidney injury (CI-AKI). 31234008 933 Rat rno-miR-144-3p miRNA oxyhemoglobin (OxyHb) intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI) primary rat cortical neurons oxyhemoglobin (OxyHb) treatment "Following ICH induction, we found miRNA-144-3p expression to increase." 30511586 934 Rat rno-miR-144-3p miRNA intracerebral hemorrhage (ICH) secondary brain injury (SBI) primary rat cortical neurons oxyhemoglobin (OxyHb) treatment "miRNA-144-3p aggravated ICH-induced SBI by targeting and downregulating FPR2, thereby contributing to neurological dysfunction and neural apoptosis via PI3K/AKT pathway activation." 30511586 935 Rat rno-miR-144-5p miRNA methamphetamine (METH) methamphetamine (METH) addiction brain tissues Methamphetamine (METH) treatment downregulated 32893733 936 Rat rno-miR-145 miRNA ethanol (EtOH) acute gastric mucosal injury gastric tissues?of rat oral administration of ethanol upregulated 23830200 937 Rat rno-miR-145 miRNA lipopolysaccharide (LPS) acute respiratory distress syndrome (ARDS) lung tissues lipopolysaccharide (LPS) treatment The miR-145 was downregulated in the LPS-induced ARDS lung 33505551 938 Rat rno-miR-145 miRNA soluble ¦Â-amyloid (sA¦Â) oligomers Alzheimer's disease (AD) cortical neurons were isolated from E17 embryos of Sprague Dawley rats sA¦Â treatment upregulated 24595404 939 Rat rno-miR-145 miRNA reactive oxygen species (ROS) cadmium-induced toxicity neonatal rat cardiomyocytes reactive oxygen species (ROS) treatment miR-145 regulates reactive oxygen species (ROS)-induced Ca2+overload in cardiomyocytes 23702479 940 Rat rno-miR-145 miRNA high glucose (HG) cardiomyocyte apoptosis rat cardiomyocytes high glucose concentration (25 mmol/L) downregulated 29178342 941 Rat rno-miR-145 miRNA oxygen glucose deprivation (OGD) cerebral ischemic stroke (CIS) rats astrocytes oxygen-glucose deprivation (OGD) treatment downregulated 29057271 942 Rat rno-miR-145 miRNA hypoxia chronic hypoxic heart disease (CHD) H9c2 cells hypoxia induce "miR©\145 was repressed by hypoxia,miR©\145 overexpression caused an inhibition in viability and facilitation in apoptosis" 31190357 943 Rat rno-miR-145 miRNA estradiol benzoate (EB) chronic inflammatory diseases dorsolateral prostate estradiol benzoate (EB) treatment upregulated 33332750 944 Rat rno-miR-145 miRNA pomegranate beverage (PG) colitis dextran sodium sulfate (DSS) induced colitis rats PG treatment upregulated 28282584 945 Rat rno-miR-145 miRNA high glucose (HG) diabetic cardiomyopathy (DCM) H9c2 cells high glucose (HG) treatment "In the HG group, miR-145 expression was significantly decreased and ARF6 expression significantly increased compared with controls." 33763154 946 Rat rno-miR-145 miRNA lithium chloride and pilocarpine epilepsy hippocampus lithium chloride-pilocarpine treatment upregulated 30465949 947 Rat rno-miR-145 miRNA lithium chloride and pilocarpine epilepsy hippocampus lithium chloride-pilocarpine treatment upregulated 30465949 948 Rat rno-miR-145 miRNA emodin hepatitis LPS-treated primary hepatocyte Emodin treatment upregulated 31079494 949 Rat rno-miR-145 miRNA lipopolysaccharide (LPS) hepatitis primary hepatocyte lipopolysaccharide (LPS) treatment downregulated 31079494 950 Rat rno-miR-145 miRNA diethylnitrosamine (DEN) hepatocellular carcinoma (HCC) liver tissues diethylnitrosamine (DEN) treatment upregulated 30412748 951 Rat rno-miR-145 miRNA pomegranate fruit aqueous extract (PGE) insulin sensitivity Alloxan-diabetic Wistar rats plasma and homogenized suspension of liver and skeletal muscle tissues long-term PGE treatment downregulated in plasma and homogenized suspension of liver and skeletal muscle tissues 29105385 952 Rat rno-miR-145 miRNA swimming left ventricular hypertrophy (LVH) rat left ventricular Swimming exercise training treatment upregulated 23812090 953 Rat rno-miR-145 miRNA TGF-¦Â liver fibrosis rat primary HSCs 10?ng/mL TGF- treatment upregulated 28091538 954 Rat rno-miR-145 miRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia induce upregulated 28980287 955 Rat rno-miR-145 miRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia treatment upregulated 29055960 956 Rat rno-miR-145 miRNA ischemia myocardial infarction (MI) rats heart tissues left anterior descending artery (LAD) ligation downregulated in heart 29218098 957 Rat rno-miR-145 miRNA hypoxia myocardial ischaemic injury rat cardiomyocytes hypoxia treatment The hypoxic insult led to the suppression of miR-145 expression in cultured rat cardiomyocytes in a concentration-dependent manner. 32138537 958 Rat rno-miR-145 miRNA Fibroblast growth factor 21 (FGF21) myocardial ischemia/reperfusion (I/R) injury (MIRI) hypoxia-induced H9c2 cells Fibroblast growth factor 21 (FGF21) treatment upregulated 30662618 959 Rat rno-miR-145 miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia induce downregulated 30662618 960 Rat rno-miR-145 miRNA geniposide (GEN) myocarditis H9c2 cells geniposide (GEN) treatment upregulated 29611016 961 Rat rno-miR-145 miRNA high fat diet (HFD) obesity rats high fat diet (HFD) feed dysregulated 24517225 962 Rat rno-miR-145 miRNA hypoxia obstructive sleep apnea (OSA) Sprague Dawley rats Vascular smooth muscle cells (VSMCs) hypoxia treatment downregulated 28465478 963 Rat rno-miR-145 miRNA tumor necrosis factor alpha (TNF-¦Á) osteoarthritis (OA) experimental OA in rats tumor necrosis factor alpha (TNF-¦Á) treatment downregulated 29072705 964 Rat rno-miR-145 miRNA angiotensin II (Ang II) oxidative stress primary cultured rat cardiomyocytes angiotensin II (Ang II) treatment downregulated 29178342 965 Rat rno-miR-145 miRNA H2O2 oxidative stress HaCaT cells H2O2 treatment Anti-antioxidant impacts of circZNF609 silence in HaCaT cells through regulating miR-145 33821719 966 Rat rno-miR-145 miRNA high glucose (HG) oxidative stress primary cultured rat cardiomyocytes Sustained high glucose concentration (25 mmol/L) treatment downregulated 29178342 967 Rat rno-miR-145 miRNA pomegranate fruit aqueous extract (PGE) oxidative stress plasma and liver and skeletal muscle tissues pomegranate fruit aqueous extract (PGE) treatment upregulated 29105385 968 Rat rno-miR-145 miRNA streptozocin (STZ) painful diabetic neuropathy (PDN) L3-5 DRG neurons streptozocin (STZ) treatment downregulated 33185386 969 Rat rno-miR-145 miRNA single dose irradiation radiation-induced lung injury (RILI) male Wistar rats lung tissues subjected to single dose irradiation with 20 Gy using 6 MV x-rays to the right lung treatment upregulated 24886372 970 Rat rno-miR-145 miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment upregulated 21094214 971 Rat rno-miR-145 miRNA TGF-¦Â acute myocardial infarction (AMI) mesenchymal stem cells (MSC) TGF-¦Â(1) treatment upregulated 21762377 972 Rat rno-miR-145-5p miRNA cationic bovine serum albumin (C-BSA) chronic glomerulonephritis (CGN) rats renal mesangial cells C-BSA treatment upregulated in renal mesangial cells 29030988 973 Rat rno-miR-145-5p miRNA ¦Â3-adrenoceptors(¦Â3-AR) inhibitor SR 59230A chronic heart failure (CHF) CHF rats 1 ml SR 59230A(85 mmoL/L in 0.9% saline)twice a day for seven weeks by intraperitoneal injection treatment upregulated 29926593 974 Rat rno-miR-145-5p miRNA puerarin diabetic nephropathy (DN) Renal Tissue puerarin treatment upregulated 33122931 975 Rat rno-miR-145-5p miRNA dioscin hepatorenal damages L-02;NRK-52E cells dioscin treatment Dioscin reduced the expression levels of miR-145-5p which directly targeted Sirt5 33836263 976 Rat rno-miR-145-5p miRNA hypoxia/reoxygenation (H/R) hypoxia/reoxygenation (H/R) injury cardiac microvascular endothelial cells (CMEC) hypoxia/reoxygenation (H/R) treatment The injured CMECs showed significantly lower miR-145-5p expression than normal ones. 32432764 977 Rat rno-miR-145-5p miRNA hypoxia hypoxic/ischemic injury Male Sprague Dawley rats "were exposed to hypoxia (9.5-10% O2) for 1, 5, or 10 days" upregulated 29262398 978 Rat rno-miR-145-5p miRNA hypoxia myocardial hypoxic/ischemic injury H9c2 cardiac cells hypoxia treatment downregulated 28281187 979 Rat rno-miR-145-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 980 Rat rno-miR-145-5p miRNA geniposide (GEN) spinal cord injury (SCI) LPS-treated PC12 cells Geniposide treatment upregulated 31307231 981 Rat rno-miR-145-5p miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC12 cells lipopolysaccharide (LPS) treatment downregulated 31307231 982 Rat rno-miR-146 miRNA hypoxia apoptosis H9c2 rat myocardial cells oxygen-glucose deprivation/recovery (OGD/R) treatment downregulated 29257202 983 Rat rno-miR-146 miRNA carbamylated albumin renal cell carcinoma (RCC) rat mesangial cells (RMCs) Carbamylated albumin treatment upregulated 21472233 984 Rat rno-miR-146a miRNA lipopolysaccharide (LPS) acute kidney injury (AKI) kidney tissues; NRK-52E cells lipopolysaccharide (LPS) treatment downregulated 29115409 985 Rat rno-miR-146a miRNA lipopolysaccharide (LPS) acute kidney injury (AKI) NRK-52E cells lipopolysaccharide (LPS) treatment downregulated 29115409 986 Rat rno-miR-146a miRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues endotoxin treatment upregulated 26137246 987 Rat rno-miR-146a miRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues lipopolysaccharide (LPS) treatment MALAT1 was upregulated and mir-146a was downregulated in lps-induced ALI rat model. 29649906 988 Rat rno-miR-146a miRNA sevoflurane (SEV) acute lung injury (ALI) lung tissues sevoflurane treatment downregulated 28617947 989 Rat rno-miR-146a miRNA lipopolysaccharide (LPS) acute Lung Injury (ALI)/acute respiratory distress syndrome (ARDS) lung tissues lipopolysaccharide (LPS) treatment upregulated 23848342 990 Rat rno-miR-146a miRNA streptozocin (STZ) aorta inflammation male Wistar rats diabetic aorta streptozocin (STZ) treatment downregulated 24824805 991 Rat rno-miR-146a miRNA acupuncture chronic atrophic gastritis (CAG) gastric acupuncture treatment downregulated 27293468 992 Rat rno-miR-146a miRNA dexmedetomidine (DEX) chronic obstructive pulmonary disease (COPD) lung dexmedetomidine (Dex) treatment downregulated 27677199 993 Rat rno-miR-146a miRNA running diabetes mellitus (DM) rats kidney exposed to 5 days of consecutive treadmill exercise for 60 min/day with the 22 m/min speed for 60 days treatment upregulated 28858844 994 Rat rno-miR-146a miRNA streptozocin (STZ) diabetes mellitus (DM) rats kindey streptozocin (STZ) treatment downregulated 28858844 995 Rat rno-miR-146a miRNA inorganic arsenic (iAs) diabetes mellitus (DM) rat insulinoma cells inorganic arsenic (iAs) exposure upregulated 31555879 996 Rat rno-miR-146a miRNA streptozocin (STZ) diabetes-related cognitive impairments serum from STZ/CC rats streptozotocin (STZ) treatment downregulated 30240403 997 Rat rno-miR-146a miRNA streptozocin (STZ) diabetic nephropathy (DN) kidney?of rat streptozotocin treatment upregulated 24057185 998 Rat rno-miR-146a miRNA high glucose (HG) diabetic peripheral neuropathy (DPN) macrophage high glucose (HG) treatment LncRNA HCG18 was highly expressed in DPN model and HG-induced macrophages. 32996080 999 Rat rno-miR-146a miRNA streptozocin (STZ) diabetic retinopathy (DR) sciatic nerve streptozotocin treatment upregulated 25567745 1000 Rat rno-miR-146a miRNA mitomycin C-polylactic acid ( MMC-PLA) film epidural scar hyperplasia and adhesion post-laminectomy rat scar tissues 25 mg of PLA film containing 0.01% MMC was implanted on the laminectomy area upregulated 28617531 1001 Rat rno-miR-146a miRNA lithium chloride and pilocarpine epilepsy brain tissues lithium-pilocarpine treatment dysregulated 29363732 1002 Rat rno-miR-146a miRNA pilocarpine epilepsy adult male rats brain tissue and heart tissue 50 days of pilocarpine treatment downregulated in the brain tissue 24530830 1003 Rat rno-miR-146a miRNA sleep deprivation epilepsy adult male rats total sleep deprivation (TSD 6 h) and paradoxical sleep deprivation (PSD 24 h) treatment significant increase of miR-146a expression 24530830 1004 Rat rno-miR-146a miRNA ulinastatin hemorrhagic shock hemorrhagic shock rats lung tissues ulinastatin treatment upregulated 31801723 1005 Rat rno-miR-146a miRNA deoxycorticosterone acetate (DOCA) -salt (sodium chloride) hypertension heart tissues deoxycorticosterone acetate (DOCA) -salt (sodium chloride) treatment downregulated 30290168 1006 Rat rno-miR-146a miRNA metformin (Met) hypertension deoxycorticosterone acetate (DOCA) -salt (sodium chloride)-induced hypertension rats heart tissues metformin (MF) treatment upregulated 30290168 1007 Rat rno-miR-146a miRNA deoxycorticosterone acetate (DOCA) -salt (sodium chloride) hypertension-induced cardiac dysfunction heart tissues deoxycorticosterone acetate (DOCA) -salt (sodium chloride) treatment downregulated 30290168 1008 Rat rno-miR-146a miRNA metformin (Met) hypertension-induced cardiac dysfunction heart tissues Metformin treatment upregulated 30290168 1009 Rat rno-miR-146a miRNA thymosin ¦Â4 (T¦Â4) hypoxic brain injury Coronal cerebellar T¦Â4 treatment microRNA 146a expression was found to have increased in Tβ4-treated BV-2 cells 26457369 1010 Rat rno-miR-146a miRNA complete freund's adjuvant (CFA) inflammatory pain dorsal root ganglion (DRG) complete Freund's adjuvant (CFA) treatment The expression of miR-146a was decreased in CFA rats. 30129228 1011 Rat rno-miR-146a miRNA fagellin (FLA) intestinal inflammation IEC18 cells fagellin (FLA) treatment upregulated 30478292 1012 Rat rno-miR-146a miRNA IL-1¦Â intestinal inflammation IEC18 cells IL-1¦Â treatment upregulated 30478292 1013 Rat rno-miR-146a miRNA lipopolysaccharide (LPS) intestinal inflammation IEC18 cells lipopolysaccharide (LPS) treatment upregulated 30478292 1014 Rat rno-miR-146a miRNA tumor necrosis factor alpha (TNF-¦Á) intestinal inflammation IEC18 cells tumor necrosis factor alpha (TNF-¦Á) treatment upregulated 30478292 1015 Rat rno-miR-146a miRNA collagenase VII intracerebral haemorrhage (ICH) brain tissues The ICH model was constructed via the stereotaxic intrastriatal injection of collagenase type VII miR-146a was significantly downregulated in ICH rats 31656540 1016 Rat rno-miR-146a miRNA cisplatin (DDP) kidney damage male Wistar rats cisplatin treatment upregulated 24880025 1017 Rat rno-miR-146a miRNA spirulina diet lactogenesis brains Spirulina-enriched diet treatment upregulated 27571388 1018 Rat rno-miR-146a miRNA heat stress lung cancer lung Heating System 2.2 (THS2.2) treatment downregulated 27866933 1019 Rat rno-miR-146a miRNA rotenone (ROT) mitochondrial dysfunction brain tissues rotenone treatment Coordinated Action of miR-146a and Parkin Gene Regulate Rotenone-induced Neurodegeneration. 32392329 1020 Rat rno-miR-146a miRNA lipopolysaccharide (LPS) myocardial dysfunction H9c2 cells lipopolysaccharide (LPS) treatment LPS Induces Oxidative Injury and miR146a Upregulation in H9C2 Cells. 30224945 1021 Rat rno-miR-146a miRNA angiotensin II (Ang II) myocardial infarction (MI) primary neonatal rat cardiac fibroblasts (CFs) and cardiomyocytes angiotensin II (Ang II) treatment inhibition of miR-146a improved cardiac dysfunction and cardiac remodeling in heart failure rats. 31763669 1022 Rat rno-miR-146a miRNA thymosin ¦Â4 (T¦Â4) neurological injury rat oligodendrocyte progenitor cells (OPCs) "T¦Â4, ranging from 25 to 100 ng/ml for 4 days treatment" upregulation 24828499 1023 Rat rno-miR-146a miRNA high fat diet (HFD) nonalcoholic fatty liver disease (NAFLD) rat high fat diet (HFD) feed upregulated 25562147 1024 Rat rno-miR-146a miRNA high fat diet (HFD) obesity lung tissue high fat diet (HFD) feed upregulated 30521085 1025 Rat rno-miR-146a miRNA high fat diet (HFD) obesity lung tissues OVA-sensitized with high-fat diet treatment in the S + HFD group the mRNA expression levels of miRNA-146a increased in the lung tissues. 30521085 1026 Rat rno-miR-146a miRNA ovalbumin (OVA) obesity lung tissue ovalbumin (OVA) treatment upregulated 30521085 1027 Rat rno-miR-146a miRNA lipopolysaccharide (LPS) osteoarthritis (OA) rat chondrocytes lipopolysaccharide (LPS) treatment The levels of miR-146a in chondrocytes treated with LPS were reduced. 31472145 1028 Rat rno-miR-146a miRNA lipopolysaccharide (LPS) osteoarthritis (OA) Isolated rat chondrocytes lipopolysaccharide (LPS) treatment "In OA cell model, the expression of miR-146a was clearly increased." 31472145 1029 Rat rno-miR-146a miRNA bone morphogenetic protein 2 (BMP2) osteogenesis rats adipose-derived mesenchymal stem cells (ADSCs) bone morphogenetic protein 2 (BMP2) treatment downregulated 28205638 1030 Rat rno-miR-146a miRNA resveratrol osteonecrosis rat bone marrow mesenchymal stem cells (BMMSCs) resveratrol (Res) treatment "Res application was associated with elevated microRNA-146a (miR-146a) expression, osteogenic differentiation, and suppressed osteoclastic differentiation, which were markedly reversed by miR-146a inhibitor" 33454992 1031 Rat rno-miR-146a miRNA H2O2 oxidative stress neuronal spinal cord (RN-sc) cells H2O2 treatment upregulated 26323253 1032 Rat rno-miR-146a miRNA H2O2 oxidative stress PC12 cells PC12 cells were stimulated with 200 ¦ÌM of H2O2 upregulated 29484526 1033 Rat rno-miR-146a miRNA high fat diet (HFD) pulmonary inflammation lung tissues high fat diet (HFD) feed upregulated 31473901 1034 Rat rno-miR-146a miRNA Trans-chalcone pulmonary inflammation High-fat diet (HFD)-fed rats lung tissues Trans-chalcone treatment downregulated 31473901 1035 Rat rno-miR-146a miRNA collagen rheumatoid arthritis (RA) synovial tissue collagen treatment downregulated 32662411 1036 Rat rno-miR-146a miRNA iguratimod rheumatoid arthritis (RA) synovial tissue of collagen-induced arthritis (CIA) rat iguratimod treatment upregulated 32662411 1037 Rat rno-miR-146a miRNA dexamethasone (DEX) sepsis-induced acute kidney injury renal tissues dexamethasone (DEX) treatment miR-146a in the renal tissues was upregulated in Dex treated group. 32415933 1038 Rat rno-miR-146a miRNA lipopolysaccharide (LPS) sepsis-induced myocardial injury myocardial tissue lipopolysaccharide (LPS) treatment upregulated 31281454 1039 Rat rno-miR-146a miRNA silicon dioxide (SiO2) silicosis fibrotic lungs silicon dioxide (SiO2) treatment upregulated 26239160 1040 Rat rno-miR-146a miRNA lithium chloride and pilocarpine status epilepticus (SE) brain tissues lithium-pilocarpine treatment upregulated 28474544 1041 Rat rno-miR-146a miRNA hypoxia stroke brain tissues middle cerebral artery occlusion (MCAO) treatment upregulation in the corpus callosum and subventricular zone (SVZ) 26738853 1042 Rat rno-miR-146a miRNA SHENMAI toxicokinetic of SHENMAI rats serum inject with SHENMAI treatment upregulated 24747029 1043 Rat rno-miR-146a miRNA streptozocin (STZ) type 2 diabetes mellitus (T2DM) hippocampus and cerebral cortex streptozocin (STZ) treatment downregulated 29867484 1044 Rat rno-miR-146a miRNA Thymoquinone (TQ) type 2 diabetes mellitus (T2DM) Type 2 diabetes mellitus (T2DM) rats hippocampus and cerebral cortex Thymoquinone (TQ) treatment upregulated 29867484 1045 Rat rno-miR-146a miRNA "2,4,6-trinitrobenzene sulfonic acid (TNBS)" ulcerative colitis (UC) rat intestinal tissues "2,4,6-Trinitrobenzenesulfonic acid (TNBS) treatment" upregulated 30915760 1046 Rat rno-miR-146a miRNA vildagliptin (Vilda) ulcerative colitis (UC) colon tissues Vildagliptin (Vilda) treatment "Vilda hsa markedly inhibited the expression of lncRNA IFNG-AS1 and miR-146a, as well as PI3K/Akt/NF¦ÊB pathway" 33434756 1047 Rat rno-miR-146a miRNA IL-4¦Â mesial temporal lobe epilepsy (MTLE) hippocampi of immature rats ?IL-1¦Â treatment upregulated 22708826 1048 Rat rno-miR-146a-3p miRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues lipopolysaccharide (LPS) treatment Reduced SIRT1 and raised miR-146a-3p were found in LPS-induced BEAS-2B cells and ALI rats. 33185125 1049 Rat rno-miR-146a-3p miRNA dexmedetomidine (DEX) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells dexamethasone (DEX) treatment Dexmedetomidine upregulated expression of miR-146a-3p. 33220608 1050 Rat rno-miR-146a-5p miRNA zhenbao pill acute spinal cord injury (ASCI) ASCI rat neuron zhenbao pill treatment upregulated 29187582 1051 Rat rno-miR-146a-5p miRNA lithium chloride and pilocarpine epilepsy rat cortex and hippocampus tissues lithium chloride-pilocarpine treatment upregulated 31061316 1052 Rat rno-miR-146a-5p miRNA intermittent hypoxia (IH) hypoxia-induced injury H9c2 cells intermittent hypoxia(IH) induced upregulated 31205587 1053 Rat rno-miR-146a-5p miRNA carbon tetrachloride (CCl4) liver fibrosis rats liver CCl4 treatment upregulated 28739486 1054 Rat rno-miR-146a-5p miRNA IL-1¦Â and TNF-¦Á osteoarthritis (OA) condylar chondrocytes IL-1¦Â and TNF-¦Á treatment upregulated 33147588 1055 Rat rno-miR-146a-5p miRNA steroids osteonecrosis osteoblasts steroid treatment downregulated 27378744 1056 Rat rno-miR-146a-5p miRNA letrozole polycystic ovarian syndrome (PCOS) ovarian tissues letrozole treatment downregulated 29505837 1057 Rat rno-miR-146a-6p miRNA angiostrongylus cantonensis (A. cantonensis) inflammation healthy male SD rats angiostrongylus cantonensis (A. cantonensis) infection upregulated 24142286 1058 Rat rno-miR-146b miRNA cisplatin (DDP) acute kidney injury (AKI) bone marrow MSCs (rMSCs) cisplatin treatment downregulated 27400799 1059 Rat rno-miR-146b miRNA circadian disruption (CD) breast cancer mammary circadian disruption (CD) treatment downregulated 26097876 1060 Rat rno-miR-146b miRNA angiotensin II (Ang II) cardiac fibrosis and hypertension cardiac fibroblasts (CFs) of rats angiotensin II (Ang II) treatment upregulated 23007623 1061 Rat rno-miR-146b miRNA TGF-¦Â liver fibrosis hepatic stellate cells (HSCs) TGF-¦Â treatment upregulated 27740527 1062 Rat rno-miR-146b miRNA aspirin-triggered resolvin D1 (AT-RvD1) hepatic ischemia/reperfusion injury (HIRI) liver ischemia/reperfusion (I/R) Sprague-Dawley rats liver aspirin-triggered resolvin D1 (AT-RvD1) treatment upregulated 28837866 1063 Rat rno-miR-146b miRNA electroacupuncture (EA) ischemic stroke (IS) Primary stem cells electroacupuncture (EA) treatment EA increased miR-146b expression. 32792909 1064 Rat rno-miR-146b miRNA porcine serum liver fibrosis rat liver tissues porcine serum treatment upregulation 24927615 1065 Rat rno-miR-146b miRNA heat stress lung cancer lung Heating System 2.2 (THS2.2) treatment downregulated 27866933 1066 Rat rno-miR-146b miRNA single dose irradiation radiation-induced lung injury (RILI) male Wistar rats lung tissues subjected to single dose irradiation with 20 Gy using 6 MV x-rays to the right lung treatment downregulated 24886372 1067 Rat rno-miR-146b-3p miRNA high fat diet (HFD) cardiac remodeling heart tissues high fat diet (HFD) feed upregulated 29884823 1068 Rat rno-miR-146b-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 1069 Rat rno-miR-146b-5p miRNA high fat diet (HFD) aging-related non-alcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD) feed upregulated 31899128 1070 Rat rno-miR-146b-5p miRNA cadmium (Cd) cadmium (Cd)-induced kidney injury renal cortex cadmium (Cd) treatment upregulated 29543730 1071 Rat rno-miR-146b-5p miRNA estradiol benzoate (EB) and testosterone (T)/E chronic inflammatory diseases dorsolateral prostate estradiol benzoate (EB) and testosterone (T)/E treatment upregulated 33332750 1072 Rat rno-miR-146b-5p miRNA lipopolysaccharide (LPS) intestinal sepsis IEC-6 cells lipopolysaccharide (LPS) treatment rno-miR-146b-5p may play a vital role in the development of sepsis intestinal injury through targeting Klf4 expression and affecting promoter activity of Ccnd2. 33200654 1073 Rat rno-miR-146b-5p miRNA oxygen glucose deprivation (OGD) neonatal hypoxic-ischemic encephalopathy PC-12 cells oxygen glucose deprivation (OGD) treatment miR-146b-5p was lower in PC12 cells upon OGD insult. 32734729 1074 Rat rno-miR-146b-5p miRNA oxygen glucose deprivation (OGD) neonatal hypoxic-ischemic brain damage oligodendrocyte precursor cells (OPCs) oxygen/glucose deprivation (OGD) induce treatment downregulated 31003769 1075 Rat rno-miR-146b-5p miRNA high fat diet (HFD) nonalcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD) feed upregulated 31915454 1076 Rat rno-miR-146b-5p miRNA Shenling Baizhu San (SLBZS) nonalcoholic fatty liver disease (NAFLD) liver tissues Shenling Baizhu San (SLBZS) treatment the expression levels were reversed by SLBZS administration 31915454 1077 Rat rno-miR-146b-5p miRNA glucocorticoid (GC) respiratory distress syndrome lung Glucocorticoids treatment downregulated 26997989 1078 Rat rno-miR-146b-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 1079 Rat rno-miR-147 miRNA H2O2 acute myocardial infarction (AMI) H9c2 cells H2O2 treatment MiR-147 expression was significantly decreased in H2O2 treated H9c2 cells. 32572895 1080 Rat rno-miR-147 miRNA mcyclic mechanical stretch endoplasmic reticulum stress (ERS) rat L6 myoblasts mcyclic mechanical stretch treatment downregulated 31628639 1081 Rat rno-miR-147 miRNA methotrexate (MTX) rheumatoid arthritis (RA) pristane (PS)-treated ATCC? CRL-2192TM cells (rat macrophage cells) methotrexate treatment upregulated 31105830 1082 Rat rno-miR-147 miRNA pristane (PS) rheumatoid arthritis (RA) ATCC? CRL-2192TM cells (rat macrophage cells) pristane (PS) treatment downregulated 31105830 1083 Rat rno-mir-147 miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 1084 Rat rno-miR-147b miRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues lipopolysaccharide (LPS) treatment MiR-147b was downregulated in lipopolysaccharide (LPS)-induced ALI rats and LPS-treated A549 cells 33660808 1085 Rat rno-miR-147b miRNA H2O2 heart failure (HF) rat H9c2 cardiomyocytes H2O2 treatment upregulated 29377979 1086 Rat rno-miR-148-3p miRNA loureirin B liver fibrosis Hepatic stellate cells (HSCs) loureirin B treatment upregulated 30123297 1087 Rat rno-miR-148-3p miRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) lung tissues monocrotaline treatment downregulated 28000863 1088 Rat rno-miR-148a miRNA cerulein acute pancreatitis (AP) The rat pancreatic acinar cell line AR42J cerulein treatment downregulated 31122822 1089 Rat rno-miR-148a-3p miRNA steroids osteonecrosis bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 26459755 1090 Rat rno-miR-148b miRNA angiotensin II (Ang II) cardiac fibrosis Cardiac myofibroblasts angiotensin II (Ang II) treatment "Ang-II downregulated the miR-148b expression, which was reversed by SRA1 siRNA, suggesting the regulation of SRA1 on miR-148b." 30694702 1091 Rat rno-miR-148b miRNA hypoxia ischemic stroke (IS) rats subventricular zone (SVZ) middle cerebral artery occlusion (MCAO) treatment upregulated 29104534 1092 Rat rno-miR-148b miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells hypoxia/reoxygenation (H/R) induce upregulated 30820984 1093 Rat rno-miR-148b-3p miRNA ginsenoside Rg1 apoptosis hypoxia-induced male rat bone marrow mesenchymal stem cells (rBMSCs) Ginsenoside Rg1 treatment upregulated 29307726 1094 Rat rno-miR-148b-3p miRNA hypoxia apoptosis Male rat bone marrow mesenchymal stem cells (rBMSCs) hypoxia induce downregulated 29307726 1095 Rat rno-miR-148b-3p miRNA pentylenetetrazol (PTZ) epilepsy brain tissues pentylenetetrazol (PTZ) treatment downregulated 32779334 1096 Rat rno-miR-148b-5p miRNA ginsenoside Rg1 apoptosis hypoxia-induced male rat bone marrow mesenchymal stem cells (rBMSCs) Ginsenoside Rg1 treatment upregulated 29307726 1097 Rat rno-miR-148b-5p miRNA hypoxia apoptosis Male rat bone marrow mesenchymal stem cells (rBMSCs) hypoxia induce downregulated 29307726 1098 Rat rno-miR-149 miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells hypoxia induce upregulated 31741467 1099 Rat rno-miR-149 miRNA "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine)" osteogenesis rat mesenchymal stem cells (MSCs) "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine) treatment" upregulated 31206187 1100 Rat rno-miR-149-5p miRNA lipopolysaccharide (LPS) intervertebral disc degeneration (IDD) nucleus pulposus (NP) cells lipopolysaccharide (LPS) treatment downregulated 31263091 1101 Rat rno-miR-149-5p miRNA hypoxia/reoxygenation (H/R) ischemia/reperfusion (I/R) injury mesenchymal stem cell (MSC) exosome hypoxia-reoxygenation (H/R) treatment upregulated 32719674 1102 Rat rno-miR-149-5p miRNA resveratrol ischemic stroke (IS) rat cerebral tissue resveratrol (RS) treatment decreased p53 protein expression and increased miR-149-5p activity on sirtuin1 (Sirt1) activation with resveratrol after 24 h following MCAO 31866350 1103 Rat rno-miR-149-5p miRNA resveratrol ischemic stroke (IS) brain tissues resveratrol (RS) treatment upregulated of Sirt1/miR-149-5p signaling may play a role in resveratrol induced protection against ischemia via p53 in rat brain 31866350 1104 Rat rno-miR-149-5p miRNA herb-partitioned moxibustion ulcerative colitis (UC) UC rats colon tissues herb-partitioned moxibustion upregulated 28246536 1105 Rat rno-miR-15 miRNA cisplatin (DDP) kidney damage male Wistar rats cisplatin treatment upregulated 24880025 1106 Rat rno-miR-15 miRNA coxsackievirus B3 (CVB3) viral myocarditis (VM) H9c2 cells Coxsackievirus B3 (CVB3) treatment MiR-15 expression was significantly upregulated in H9c2 cells after CVB3 infection. 32099552 1107 Rat rno-miR-150 miRNA H2O2 acute myocardial infarction (AMI) H9c2 cells H2O2 treatment FTX relieves H2O2-induced cardiomyocyte injury by increasing KLF13 expression via depletion of miR-150. 33817286 1108 Rat rno-miR-150 miRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment downregulated 27649667 1109 Rat rno-miR-150 miRNA H2O2 cardiac injury cardiac myocytes ?H2O2 treatment upregulated 23824072 1110 Rat rno-miR-150 miRNA high glucose (HG) cardiac hypertrophy rat cardiac cells high glucose treatment downregulated 23211718 1111 Rat rno-miR-150 miRNA ¦Â-arrestin1-biased ¦Â1-adrenergic receptor ischemic injury embryonic ventricular cardiomyocyte H9c2 cells ¦Â-arrestin1-biased ¦Â1-adrenergic receptor treatment upregulated 25824147 1112 Rat rno-miR-150 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 1113 Rat rno-miR-150 miRNA H2O2 oxidative stress neuronal spinal cord (RN-sc) cells H2O2 treatment upregulated 26323253 1114 Rat rno-miR-150 miRNA tetramethylpyrazine (TMP) parkinson's disease (PD) hippocampu Tetramethylpyrazine (TMP) treatment Tetramethylpyrazine ameliorates isoflurane-induced cognitive dysfunction by inhibiting neuroinflammation via miR-150 in rats 32855738 1115 Rat rno-miR-150 miRNA hypoxia pulmonary hypertension (PH) lung tissue and plasma hypoxia induce downregulated 30551428 1116 Rat rno-miR-150 miRNA hypoxia pulmonary hypertension (PH) lung tissue and plasma hypoxia treatment miR-150 level was reduced in the lung tissue and plasma of hypoxia-treated rats. 30551428 1117 Rat rno-miR-150 miRNA lipopolysaccharide (LPS) septic shock Wistar rats serum LPS (10 mg/kg) treatment upregulated 24915805 1118 Rat rno-miR-150 miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment upregulated 21094214 1119 Rat rno-miR-1502 miRNA quercetin oxidative stress PC-12 cells Quercetin treatment downregulated 33343808 1120 Rat rno-miR-150-3p miRNA CP (cyclophosphamide) cyclophosphamide (CP)-induced lung toxicity lung tissues CP (cyclophosphamide) treatment Single treatment with CP caused a significant increase in the relative gene expression of miR-150-3p compared to control rats. 32747644 1121 Rat rno-miR-150-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 1122 Rat rno-miR-150-5p miRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia treatment "XIST protects cardiomyocytes from hypoxia-induced injury by mediating miR-150-5p/Bax axis, suggesting that XIST is an important target for AMI treatment." 32096185 1123 Rat rno-miR-150-5p miRNA isoproterenol cardiac hypertrophy Neonatal rat ventricular myocytes (NRVMs) isoproterenol (ISO) treatment downregulated 29786749 1124 Rat rno-miR-150-5p miRNA fish oil (FO) and olive oil (OO) cardiovascular responses heart sissues Fish oil (FO) and olive oil (OO) treatment O 3-induced upregulated of miR-150-5p and miR-208a-5p were attenuated by FO and/or OO. 33091443 1125 Rat rno-miR-150-5p miRNA chronic heart failure (CHF) chronic heart failure (CHF) myocardial tissues aerobic exercise treatment downregulated 33708967 1126 Rat rno-miR-150-5p miRNA high glucose (HG) diabetic cardiomyopathy (DCM) cardiac fibroblasts (CFs) high glucose (HG) treatment upregulated 31710102 1127 Rat rno-miR-150-5p miRNA high glucose (HG) diabetic cardiomyopathy (DCM) cardiac fibroblasts (CFs) high-glucose (HG) treatment upregulated 31710102 1128 Rat rno-miR-150-5p miRNA carbon tetrachloride (CCl4) liver fibrosis liver tissues carbon tetrachloride (CCl4) treatment miR-150-5p was upregulated on carbon tetrachloride (CCl4) injection for 8 weeks. 31833387 1129 Rat rno-miR-150-5p miRNA uterine perfusion pressure (RUPP) pregnancy-induced hypertension (PIH) aortic endothelial cells (ECs) uterine perfusion pressure (RUPP) treatment downregulated 32800559 1130 Rat rno-miR-150-5p miRNA lipopolysaccharide (LPS) sepsis H9c2 cells; heart tissues lipopolysaccharide (LPS) treatment downregulated 32908879 1131 Rat rno-miR-150-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 1132 Rat rno-miR-151 miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment upregulated 21094214 1133 Rat rno-miR-151* miRNA aflatoxin B1 (AFB1) hepatocellular carcinoma (HCC) 7-week-old Fischer344 male rats liver aflatoxin B1 (AFB5) treatment upregulated 24472605 1134 Rat rno-miR-151-3p miRNA dexamethasone (DEX) Alzheimer's disease (AD) PC12 cells dexamethasone (DEX) treatment upregulated of miRNA-151-3p enhanced the neuroprotective effect of dexmedetomidine against ¦Â-amyloid by targeting DAPK-1 and TP53. 33275947 1135 Rat rno-miR-151-3p miRNA cold cold stress rats serum cold conditions (4¡æ for 12h) downregulated 28477904 1136 Rat rno-miR-151-3p miRNA long-term potentiation(LTP) long-term potentiation (LTP) persistence Sprague-Dawley rats Dentate Gyrus Neuropil unilaterally at perforant path-dentate gyrus synapses upregulated in Dentate Gyrus Neuropil 28125614 1137 Rat rno-miR-151-5p miRNA house dust mite (HDM) extract allergic airway inflammation adipose tissue and lungs house dust mite extract treatment upregulated 32887419 1138 Rat rno-miR-152 miRNA carbon tetrachloride (CCl4) liver fibrosis liver tissues carbon tetrachloride (CCl4) treatment downregulated 31258681 1139 Rat rno-miR-152 miRNA high fat diet (HFD) nonalcoholic fatty liver disease (NAFLD) rat high fat diet (HFD) feed upregulated 25562147 1140 Rat rno-miR-152 miRNA astragalus polysaccharide (APS) osteogenesis marrow mesenchymal stem cells (MSCs) Astragalus polysaccharide (APS) treatment downregulated 31071509 1141 Rat rno-miR-152 miRNA "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine)" rheumatoid arthritis (RA) synovium "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine) treatment" upregulated 26093272 1142 Rat rno-miR-152-3p miRNA pentylenetetrazol (PTZ) epilepsy brain tissues pentylenetetrazol (PTZ) treatment downregulated 32779334 1143 Rat rno-miR-152-3p miRNA tanshinone IIA (Tan IIA) heart failure (HF) H9C2 cells tanshinone IIA treatment upregulated 27508033 1144 Rat rno-miR-153 miRNA H2O2 cardiovascular disease (CVD) primary culture of rat ventricular cardiomyocytes primary culture of rat ventricular cardiomyocytes treatment upregulated 27220418 1145 Rat rno-miR-153 miRNA hypoxia hypoxia-induced injury rat pheochromocytoma (PC-12) cells hypoxia induce downregulated 30579328 1146 Rat rno-miR-153 miRNA propofol (PPF) hypoxia-induced injury ?hypoxia-induced rat pheochromocytoma (PC-12) cells propofol treatment upregulated 30579328 1147 Rat rno-miR-153 miRNA oxygen glucose deprivation (OGD) ischemic brain injury Hippocampal neuronal oxygen-glucose deprivation (OGD) treatment upregulated 27074745 1148 Rat rno-miR-153 miRNA lead acetate (PbAc) lead-induced hepatotoxicity liver tissues and primary cultured hepatocytes lead acetate (PbAc) treatment upregulated 29175668 1149 Rat rno-miR-153 miRNA grape seed proanthocyanidins (GSPs) lepatotoxicity lead acetate (PbAc)-treated rats liver tissues and primary cultured hepatocytes Grape seed procyanidin extract (GSPE) treatment downregulated 29175668 1150 Rat rno-miR-153 miRNA grape seed procyanidin extract (GSPE) liver damage rat primary hepatocytes pretreated with PbAc (100 ¦ÌM) GSPE (100 ¦Ìg/ml) downregulated 29175668 1151 Rat rno-miR-153 miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) primary cultured rat cardiomyocytes oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 31037501 1152 Rat rno-miR-153 miRNA grape seed procyanidin extract (GSPE) nephrotoxicity Pb induced nephrotoxicity rat vemurafenib downregulated 28178683 1153 Rat rno-miR-153-3p miRNA hypoxia ischemic stroke (IS) HUVECs pMCAO treatment downregulated in infraction areas 28985553 1154 Rat rno-miR-154-3p miRNA IL-6 skeletal muscle regeneration rat primary skeletal muscle cells (RSkMC) IL-6 treatment upregulated 31820147 1155 Rat rno-miR-154-3p miRNA IL-6 skeletal muscle regeneration rat primary skeletal muscle cells (RSkMC) IL-6 treatment upregulated 31820147 1156 Rat rno-miR-155 miRNA IL-1¦Â intervertebral disc degeneration (IDD) nucleus pulposus (NP) cells IL-1¦Â treatment downregulated 29852820 1157 Rat rno-miR-155 miRNA tumor necrosis factor alpha (TNF-¦Á) intervertebral disc degeneration (IDD) nucleus pulposus (NP) cells tumor necrosis factor alpha (TNF-¦Á) treatment downregulated 29852820 1158 Rat rno-miR-155 miRNA hypoxia/reoxygenation (H/R) acute kidney injury (AKI) NRK-52E cells hypoxia-reoxygeneration (H/R) induce upregulated 31216555 1159 Rat rno-miR-155 miRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues endotoxin treatment upregulated 26137246 1160 Rat rno-miR-155 miRNA sevoflurane (SEV) acute lung injury (ALI) lung tissues sevoflurane treatment downregulated 28617947 1161 Rat rno-miR-155 miRNA H2O2 acute myocardial infarction (AMI) neonatal rat ventricular cardiomyocyte (NRVM) H2O2 treatment upregulated 31191799 1162 Rat rno-miR-155 miRNA galantamine adjuvant-induced arthritis (AIA) joint galantamine treatment miR-155 was downregulated in galantamine treated group when compared with AA mice. 32621912 1163 Rat rno-miR-155 miRNA ovalbumin (OVA) asthma lung tissues ovalbumin (OVA) treatment upregulated 29938673 1164 Rat rno-miR-155 miRNA gold nanoparticles (AuNPs) AuNP-induced lung pathogenesis lung tissues gold nanoparticles (AuNPs) treatment upregulated 31413563 1165 Rat rno-miR-155 miRNA high glucose (HG) cardiac fibrosis H9c2 cells high glucose (HG) treatment HG treatment resulted in increased miR-155 expression. 32901848 1166 Rat rno-miR-155 miRNA docosahexaenoic acid (DHA) carotid restenosis VSMCs docosahexaenoic acid (DHA) treatment Docosahexaenoic acid inhibits vascular smooth muscle cell migration and proliferation by decreasing microRNA-155 expression levels 32945419 1167 Rat rno-miR-155 miRNA valproic acid (VPA) cerebral ischemia injury (CII) rat cortical neuronal cells valproic acid treatment upregulated 22937209 1168 Rat rno-miR-155 miRNA acupuncture chronic atrophic gastritis (CAG) gastric acupuncture treatment downregulated 27293468 1169 Rat rno-miR-155 miRNA paradoxical sleep deprivation (PSD) cognitive impairment Hippocampal tissues paradoxical sleep deprivation (PSD) induce treatment upregulated 31279826 1170 Rat rno-miR-155 miRNA saikosaponin d (SSd) depression hippocampal neurons saikosaponin d (SSd) treatment "SSd could ameliorate depression-like behaviors in the rats treated with UCMS by downregulating NF-¦ÊB and miR-155, and upregulating FGF2" 31926302 1171 Rat rno-miR-155 miRNA tetrandrine diabetes mellitus (DM) rat pancreatic islet caused by alloxan Tetrandrine treatment downregulated 26064305 1172 Rat rno-miR-155 miRNA ibuprofen diabetic nephropathy (DN) spinal tissues ibuprofen treatment downregulated 27392937 1173 Rat rno-miR-155 miRNA L©\arginine diabetic nephropathy (DN) spinal L-arginine treatment downregulated 27392937 1174 Rat rno-miR-155 miRNA glucose diabetic peripheral neuropathy (DPN) rat Schwann cells (SCs) 5.5 mM glucose treatment "miR-155 antagomir-induced inhibition increased MNCV and SNCV, strengthened angiogenesis and alleviated inflammation in DPN rats." 31404910 1175 Rat rno-miR-155 miRNA atorvastatin endothelial dysfunction erectile tissue of the aged rat atorvastatin treatment downregulated 29686722 1176 Rat rno-miR-155 miRNA Saikosaponin a (Ssa) epilepsy hippocampus Ssa treatment downregulated 28958944 1177 Rat rno-miR-155 miRNA light focal retinal degeneration right eye light treatment upregulated 25921151 1178 Rat rno-miR-155 miRNA electroacupuncture (EA) head and neck squamous cell carcinoma (HNSCC) rat peritoneal mast cells (RPMCs) electro-acupuncture (EA) treatment downregulated 29404871 1179 Rat rno-miR-155 miRNA perfluorooctane sulfonic acid (PFOS) hepatomegaly HepG2 cells perfluorooctane sulfonate (PFOS) treatment upregulated 26844784 1180 Rat rno-miR-155 miRNA asiaticoside hyperoxia-induced bronchopulmonary dysplasia lung tissues asiaticoside treatment Asiaticoside downregulated the expression of miR-155. 31948528 1181 Rat rno-miR-155 miRNA deoxycorticosterone acetate (DOCA) -salt (sodium chloride) hypertension heart tissues deoxycorticosterone acetate (DOCA) -salt (sodium chloride) treatment upregulated 30290168 1182 Rat rno-miR-155 miRNA metformin (Met) hypertension deoxycorticosterone acetate (DOCA) -salt (sodium chloride)-induced hypertension rats heart tissues metformin (MF) treatment downregulated 30290168 1183 Rat rno-miR-155 miRNA deoxycorticosterone acetate (DOCA) -salt (sodium chloride) hypertension-induced cardiac dysfunction heart tissues deoxycorticosterone acetate (DOCA) -salt (sodium chloride) treatment upregulated 30290168 1184 Rat rno-miR-155 miRNA metformin (Met) hypertension-induced cardiac dysfunction heart tissues Metformin treatment downregulated 30290168 1185 Rat rno-miR-155 miRNA lipopolysaccharide (LPS) inflammation rat alveolar macrophages NR8383 lipopolysaccharide (LPS) treatment upregulated 30541646 1186 Rat rno-miR-155 miRNA gualou guizhi decoction (GLGZD) ischemic stroke (IS) brain tissues Gualou Guizhi Decoction (GLGZD) treatment "GLGZD was able to inhibit miR-155 upregulation, resulting in downregulated of miR155-targeted molecules in MCAO rats" 33081480 1187 Rat rno-miR-155 miRNA lipopolysaccharide (LPS) hepatocellular carcinoma (HCC) rat spleen myeloid cells lipopolysaccharide (LPS) treatment mature miR-155 is overexpressed in rat spleen myeloid cells treated with LPS 23329697 1188 Rat rno-miR-155 miRNA acetaminophen (APAP) liver damage liver tissues acetaminophen (APAP) treatment "miR-155 and miR-21 were evaluated as makers of inflammation and regeneration, respectively, to characterize liver status." 27051339 1189 Rat rno-miR-155 miRNA dexmedetomidine (DEX) LPS-induced neuroinflammation "adult Wistar rats brain ,plasma," dexmedetomidine (Dex) treatment downregulated 28832497 1190 Rat rno-miR-155 miRNA lipopolysaccharide (LPS) myocardial infarction (MI) rat bone marrow derived macrophages (BMDMs) lipopolysaccharide (LPS) treatment upregulated 31207208 1191 Rat rno-miR-155 miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cell hypoxia/reoxygenation (H/R) induce upregulated 31807249 1192 Rat rno-miR-155 miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) treatment miR-155 was markedly upregulated in the H/R model. 31922242 1193 Rat rno-miR-155 miRNA lipopolysaccharide (LPS) neuroinflammation adult Wistar rats brain regions lipopolysaccharide (LPS) treatment upregulated in both brain regions 28832497 1194 Rat rno-miR-155 miRNA bortezomib neuropathic pain (NP) L5-L6 spinal cord dorsal horn bortezomib? treatment Inhibition of microRNA-155 Reduces Neuropathic Pain During Chemotherapeutic Bortezomib via Engagement of Neuroinflammation. 32296644 1195 Rat rno-miR-155 miRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment downregulated 30373531 1196 Rat rno-miR-155 miRNA myo-inositol polycystic ovarian syndrome (PCOS) ovaries Myo-inositol treatment downregulated of miR-155 was detected with myo-inositol supplementation. 32045334 1197 Rat rno-miR-155 miRNA N-3 polyunsaturated fatty acids (PUFA) post-menopausal depression brain tissues N-3 polyunsaturated fatty acids (PUFA) treatment "N-3 PUFA decreased blood levels of adrenocorticotropic hormone and corticosterone, and brain expressions of corticotropin-releasing factor and miRNA-218, which increased the expression of the glucocorticoid receptor. N-3 PUFA decreased the expression of tumor necrosis factor-¦Á, interleukin (IL)-6, IL-1¦Â, and prostaglandin E2, while increased the expression of miRNA-155." 33548474 1198 Rat rno-miR-155 miRNA nitric oxide synthase inhibitor L-NAME pregnancy-induced hypertension (PIH) pregnant female rats placental tissues nitric oxide synthase inhibitor L-NAME treatment upregulated 30402830 1199 Rat rno-miR-155 miRNA ischemia/reperfusion (I/R) renal ischemia/reperfusion (I/R) injury kidney tissues ischemia/reperfusion (I/R) treatment upregulated 28006785 1200 Rat rno-miR-155 miRNA lipopolysaccharide (LPS) rheumatoid arthritis (RA) rat synoviocytes lipopolysaccharide (LPS) treatment upregulated 31258713 1201 Rat rno-miR-155 miRNA lipopolysaccharide (LPS) sepsis-induced lung injury NR8383 macrophages lipopolysaccharide (LPS) treatment upregulated 28125526 1202 Rat rno-miR-155 miRNA kainic acid (KA) status epilepticus (SE) hippocampus kainic acidtreatment upregulated 30006293 1203 Rat rno-miR-155 miRNA gualou guizhi decoction (GLGZD) stroke ischemic hemisphere Gualou Guizhi Decoction (GLGZD) treatment GLGZD was able to inhibit miR-155 upregulation. 33081480 1204 Rat rno-miR-155 miRNA exercise training (ET) vascular relaxation arteries exercise training downregulated 32301852 1205 Rat rno-miR-155-3p miRNA puerarin bone graft defects bone mesenchymal stem cells (BMSCs) puerarin treatment miR-155-3p expression was increased by puerarin in BMScs 32377717 1206 Rat rno-miR-155-3p miRNA TGF-¦Â1 lung fibrosis lung fibroblasts TGF-¦Â1 treatment downregulated 32464548 1207 Rat rno-miR-155-3p miRNA TGF-¦Â1 lung fibrosis lung fibroblasts TGF-¦Â1 treatment upregulated 32464548 1208 Rat rno-miR-155-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 1209 Rat rno-miR-155-3p miRNA diosgenin glucoside (DG) spinal cord injury (SCI) Spinal cord injury (SCI) rats spinal cord tissue Diosgenin glucoside (DG) treatment downregulated 30072674 1210 Rat rno-miR-155-5p miRNA high fat diet (HFD) aging-related non-alcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD) feed upregulated 31899128 1211 Rat rno-miR-155-5p miRNA alcohol alcoholic cardiomyopathy (ACM) heart tissues alcohol exposure alcohol drinking significantly upregulated miR-155-5p level 33868799 1212 Rat rno-miR-155-5p miRNA rapamycin cardiac fibrosis heart tissues rapamycin (Rap) treatment upregulated 30647817 1213 Rat rno-miR-155-5p miRNA valproic acid (VPA) cell differentiation primary cultured neural stem cells (NSCs) valproate (VPA) treatment upregulated 29575035 1214 Rat rno-miR-155-5p miRNA geniposide and ginsenoside Rg1 cerebral ischemia injury (CII) middle cerebral artery occlusion treated rats brain tissues Geniposide+Ginsenoside Rg1 dual treatment downregulated 29257264 1215 Rat rno-miR-155-5p miRNA dihydromyricetin (DHM) diabetic nephropathy (DN) NRK-52E?cells; kidney tissues high glucose (HG) treatment "MiR-155-5p expression was increased, while PTEN expression was decreased in DN rat and cell model, and DHM reversed both effects." 31668144 1216 Rat rno-miR-155-5p miRNA high glucose (HG) diabetic nephropathy (DN) NRK-52E?cells high glucose (HG) treatment upregulated 31668144 1217 Rat rno-miR-155-5p miRNA isoproterenol drug-induced cardiac injury (DICI) heart tissues isoproterenol treatment upregulated 29355689 1218 Rat rno-miR-155-5p miRNA pilocarpine epilepsy hippocampus pilocarpine treatment upregulated 29191771 1219 Rat rno-miR-155-5p miRNA plasminogen activator (tPA) neuropathy-induced blood-nerve barrier (BNB) opening sciatic nerve from male rats plasminogen activator (tPA) treatment upregulated 30625382 1220 Rat rno-miR-155-5p miRNA high fat diet (HFD) nonalcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD) feed upregulated 31915454 1221 Rat rno-miR-155-5p miRNA Shenling Baizhu San (SLBZS) nonalcoholic fatty liver disease (NAFLD) liver tissues Shenling Baizhu San (SLBZS) treatment the expression levels were reversed by SLBZS administration 31915454 1222 Rat rno-miR-155-5p miRNA group A streptococci rheumatic heart disease (RHD) valve tissues and serum exosomes an RHD rat model was induced by inactivated Group A streptococci and complete Freund's adjuvant. upregulated 31894293 1223 Rat rno-miR-155-5p miRNA group A streptococci and complete Freund's adjuvant rheumatic heart disease (RHD) valve tissues; serum exosomes group A streptococci and complete Freund's adjuvant treatment The expression of miR-155-5p in valve tissues and serum exosomes was increased. 31894293 1224 Rat rno-miR-155-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 1225 Rat rno-miR-155-5p miRNA silica silicosis rats lung tissues silica treatment upregulated 31877411 1226 Rat rno-miR-155-5p miRNA silica silicosis lung tissues silica treatment upregulated 31877411 1227 Rat rno-miR-155-5p miRNA geniposide and ginsenoside Rg2 stroke middle cerebral artery occlusion rats "geniposide (30 mg/kg, tail vein injection)+ ginsenoside Rg1 (6 mg/kg, tail vein injection)" upregulated 29257264 1228 Rat rno-miR-155-5p miRNA tumor necrosis factor alpha (TNF-¦Á) subacute thyroiditis rat thyroid follicle FRTL-5 cells tumor necrosis factor alpha (TNF-¦Á) treatment upregulated 30399324 1229 Rat rno-miR-155-5p miRNA pilocarpine temporal lobe epilepsy (TLE) rats hippocampus pilocarpine treatment upregulated in hippocampus 29191771 1230 Rat rno-miR-155-5p miRNA cadmium (Cd) vascular calcification (VC) rat vascular smooth muscle cells (rVSMCs) CaCl2 treatment miR-155-5p was decreased in the rat vascular smooth muscle cells (rVSMCs) undergoing calcification in vitro. 32345535 1231 Rat rno-miR-156 miRNA dexmedetomidine (DEX) neuroinflammation "adult Wistar rats brain ,plasma," dexmedetomidine (Dex) treatment downregulated 28832497 1232 Rat rno-miR-15a miRNA ischemia/reperfusion (I/R) apoptosis heart tissues ischemia/reperfusion (I/R) treatment upregulated 24043355 1233 Rat rno-miR-15a miRNA freund¡¯s complete adjuvant (FCA) arthritis Sprague-Dawley rats injected with Freund's complete adjuvant downregulated 28877850 1234 Rat rno-miR-15a miRNA gabapentin arthritis Sprague-Dawley rats administered intraperitoneally gabapentin for 8 days upregulated 28877850 1235 Rat rno-miR-15a miRNA hypoxia glial scars DI TNC1 cells hypoxia treatment upregulated 27460735 1236 Rat rno-miR-15a miRNA insulin glucose homeostasis L6 rat skeletal muscle cells insulin treatment upregulated 31594761 1237 Rat rno-miR-15a miRNA hypoxia hypoxia-induced injury PC-12 cells hypoxia induce upregulated 30395900 1238 Rat rno-miR-15a miRNA sappanone A hypoxia-induced injury hypoxia-induced PC-12 cells sappanone A treatment downregulated 30395900 1239 Rat rno-miR-15a miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic brain injury primary cortical neu- rons oxygen-glucose deprivation and reoxygenation (OGD/R) treatment miR-15a expression level in OGD/R group was increased. 31631531 1240 Rat rno-miR-15a miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic brain injury primary cortical neurons separated from rats oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 31631531 1241 Rat rno-miR-15a miRNA hypoxia neurological injury PC-12 cells hypoxia induce upregulated 30395900 1242 Rat rno-miR-15a miRNA Sappanone A neurological injury hypoxia-induced PC-12 cells Sappanone A treatment downregulated 30395900 1243 Rat rno-miR-15a miRNA chronic constriction injury (CCI) neuropathic pain (NP) Rat lumbar spinal cord tissues chronic constriction injury (CCI) induce downregulated 31736006 1244 Rat rno-miR-15a miRNA insulin-like growth factor 1 (IGF-1) post-stroke brain tissues Post-stroke ICV administration of IGF-1 to middle-aged female rats treatment downregulated 24618563 1245 Rat rno-miR-15a miRNA pilocarpine temporal lobe epilepsy (TLE) TLE tissues pilocarpine treatment mir-15a was significantly downregulated in the TLE tissues 32945401 1246 Rat rno-miR-15a-5p miRNA methylprednisolone femoral head necrosis (FHN) femoral head tissues methylpred-nisolone treatment upregulated 30957181 1247 Rat rno-miR-15a-5p miRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) lung tissues monocrotaline (MCT) treatment upregulated 31894295 1248 Rat rno-miR-15b miRNA hypoxia/reoxygenation (H/R) acute myocardial infarction (AMI) H9c2 cells hypoxia/reoxygenation (H/R) treatment "In H9c2 cells, hypoxia/reoxygenation induced increased miRNA-15b expression and augmented cardiomyocyte apoptosis observed at 24?hours after 24-hour hypoxia." 28814571 1249 Rat rno-miR-15b miRNA ischemia/reperfusion (I/R) acute myocardial infarction (AMI) heart tissues ischemia/reperfusion (I/R) treatment upregulated 28814571 1250 Rat rno-miR-15b miRNA glycochenodeoxycholate (GCDC) apoptosis liver tissues glycochenodeoxycholate (GCDC) treatment upregulated 31152635 1251 Rat rno-miR-15b miRNA hypoxia apoptosis Neonatal rat ventricular myocytes (NRVMs) and fibroblasts hypoxia induce downregulated 30876857 1252 Rat rno-miR-15b miRNA ischemia/reperfusion (I/R) apoptosis heart tissues ischemia/reperfusion (I/R) treatment upregulated 24043355 1253 Rat rno-miR-15b miRNA tauroursodeoxycholate (TUDC) apoptosis glycochenodeoxycholate (GCDC)-induced rats liver tissues Tauroursodeoxycholate (TUDC) treatment downregulated 31152635 1254 Rat rno-miR-15b miRNA TGF-¦Â1 apoptosis Neonatal rat ventricular fibroblasts TGF-¦Â1 treatment downregulated 30876857 1255 Rat rno-miR-15b miRNA allopurinol cardiac fibrosis fructose-treated rats heart tissues and H9c2 cells allopurinol treatment upregulated 31871537 1256 Rat rno-miR-15b miRNA fructose cardiac fibrosis rats heart tissues and H9c2 cells fructose treatment downregulated 31871537 1257 Rat rno-miR-15b miRNA Pterostilbene cardiac fibrosis fructose-treated rats heart tissues and H9c2 cells Pterostilbene treatment upregulated 31871537 1258 Rat rno-miR-15b miRNA mild hypothermia cerebral ischemia injury (CII) brain tissues applying ice packs around the neck and head downregulated 30276328 1259 Rat rno-miR-15b miRNA oxaliplatin chronic neuropathic pain rats dorsal root ganglion (DRG) injections of oxaliplatin (2 mg¡¤kg-1 ) for five consecutive days upregulated in the dorsal root ganglion (DRG) 28012171 1260 Rat rno-miR-15b miRNA streptozocin (STZ) diabetic retinopathy (DR) retinal capillary endothelial cells and pericytes streptozotocin treatment downregulated 31364104 1261 Rat rno-miR-15b miRNA ionizing radiation (IR) irradiation-induced heart damage rat myocardium Single irradiation of 10 Gy (4¨C5 Gy/min.) of rat¡¯s mediastinum area downregulated 30830529 1262 Rat rno-miR-15b miRNA molecular hydrogen-rich water (HRW) irradiation-induced heart damage irradiation-induced rat myocardium molecular hydrogen-rich water (HRW) treatment upregulated 30830529 1263 Rat rno-miR-15b miRNA losartan ischemia/reperfusion (I/R) injury heart tissues losartan treatment upregulated 26168042 1264 Rat rno-miR-15b miRNA kaempferol ischemic heart disease (IHD) H9c2 cells Kaempferol (Kae) treatment Kae exposure promoted downregulated of miR-15b. 32418959 1265 Rat rno-miR-15b miRNA apigenin myocardial ischemia/reperfusion (I/R) injury (MIRI) hypoxia-induced H9C2 cells apigenin treatment downregulated 30983593 1266 Rat rno-miR-15b miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells hypoxia induce upregulated 30983593 1267 Rat rno-miR-15b miRNA "quinacrine, erythromycin and tetracycline" non-surgical sterilization Wistar albino 12-14 week old female rats "quinacrine, erythromycin , tetracycline treatment" upregulated 25195052 1268 Rat rno-miR-15b miRNA high amplitude mechanical stretching lung fibrosis alveolar type II (ATII) cells and lung fibroblasts high amplitude mechanical stretching treatment upregulated 31290711 1269 Rat rno-miR-15b miRNA doxorubicin (DOX) renal interstitial fibrosis (RIF) kidneys doxorubicin (ADR) induction upregulated 32606425 1270 Rat rno-miR-15b miRNA "kangxianling (KXL, anti-fibrin)" renal interstitial fibrosis (RIF) kidneys "Kangxianling (KXL, anti-fibrin) treatment" downregulated 32606425 1271 Rat rno-miR-16 miRNA nicotine allergic asthma (AA) lung tissues nicotine injections upregulated 28381639 1272 Rat rno-miR-16 miRNA amyloid-¦Â (A¦Â) Alzheimer's disease (AD) PC12 cells amyloid-¦Â (A¦Â) treatment downregulated 30142113 1273 Rat rno-miR-16 miRNA glycochenodeoxycholate (GCDC) apoptosis liver tissues glycochenodeoxycholate (GCDC) treatment upregulated 31152635 1274 Rat rno-miR-16 miRNA hypoxia apoptosis Bone marrow-derived mesenchymal stem cells (BM-MSCs) hypoxia/serum deprivation (SD) induce upregulated 29767235 1275 Rat rno-miR-16 miRNA partial hepatectomy (PH) apoptosis wistar rats liver tissues PHS (70% PH); PHP (70% PH of an organ perfused and preserved for 24 hours) treatment downregulated 25131054 1276 Rat rno-miR-16 miRNA tauroursodeoxycholate (TUDC) apoptosis glycochenodeoxycholate (GCDC)-induced rats liver tissues Tauroursodeoxycholate (TUDC) treatment downregulated 31152635 1277 Rat rno-miR-16 miRNA valsartan (VAL) arrhythmogenesis H9c2 valsartan treatment downregulated 26654716 1278 Rat rno-miR-16 miRNA H2O2 cardiomyocyte oxidative injury neonatal rat ventricular cells (NRVCs) hydrogen peroxide upregulated 28423616 1279 Rat rno-miR-16 miRNA thyroglobulin (Tg) cell proliferation rat FRTL-5 thyroid cells Tg treatment upregulated 24479877 1280 Rat rno-miR-16 miRNA chronic unpredictable mild stress (CUMS) depression cerebrospinal fluid (CSF) and raphe chronic unpredictable mild stress (CUMS) treatment downregulated 29957478 1281 Rat rno-miR-16 miRNA dingzhi Xiaowan (DZ) depression unpredictable mild moderate stimulation (CUMS)-induced depression rats hippocampus Dingzhi Xiaowan (DZ) treatment upregulated 30347920 1282 Rat rno-miR-16 miRNA mitomycin C-polylactic acid ( MMC-PLA) film epidural scar hyperplasia and adhesion post-laminectomy rat scar tissues 25 mg of PLA film containing 0.01% MMC was implanted on the laminectomy area downregulated 28617531 1283 Rat rno-miR-16 miRNA hypoxia glial scars DI TNC1 cells hypoxia treatment upregulated 27460735 1284 Rat rno-miR-16 miRNA "acetaminophen, carbon tetrachloride, D-galactosamine and thioacetamide" hepatotoxicity rat liver cells hepatotoxins treatment "the combination of MicroRNA-16/5S Ribosomal RNA and Beta 2 Microglobulin/18S Ribosomal RNA were validated as optimal reference genes for microRNA and mRNA quantification, respectively, in rat models of acute hepatotoxicity." 22563491 1285 Rat rno-miR-16 miRNA lipopolysaccharide (LPS) intervertebral disc degeneration (IDD) NP cells lipopolysaccharide (LPS) treatment MiR-16 was downregulated in NP cells after LPS induction. 33747285 1286 Rat rno-miR-16 miRNA cisplatin (DDP) kidney damage male Wistar rats cisplatin treatment upregulated 24880025 1287 Rat rno-miR-16 miRNA hypoxia myocardial hypoxia/reoxygenation (H/R) injury H9c2(2-1) cells hypoxia induce upregulated 31432171 1288 Rat rno-miR-16 miRNA lipopolysaccharide (LPS) myocarditis H9c2 cells lipopolysaccharide (LPS) treatment downregulated 31777165 1289 Rat rno-miR-16 miRNA lipopolysaccharide (LPS) myocarditis H9C2 cells lipopolysaccharide (LPS) treatment upregulation of miR-16 has a protective effect on LPS-damaged H9c2 cells. 31777165 1290 Rat rno-miR-16 miRNA destabilization of medial meniscus (DMM) osteoarthritis (OA) male Sprague¨CDawley rats OA cartilage tissues destabilization of medial meniscus (DMM) treatment upregulated 29255591 1291 Rat rno-miR-16 miRNA destabilization of medial meniscus (DMM) osteogenesis bone marrow mesenchymal stem cells (BMSCs) MgCl2 treatment MgCl2 causes the decreases of miR-16 levels. 32411326 1292 Rat rno-miR-16 miRNA stress post-traumatic stress disorder (PTSD) Wistar rats HIP controlled lighting (light on 07:00¨C19:00 hr) and temperature (25 ¡À 2¡ãC) conditions with ad libitum access to food and water treatment upregulated 28944448 1293 Rat rno-miR-16 miRNA "paroxetine hydrochloride and corticotropin-releasing factor antagonist (CP-154,526)" post-traumatic stress disorder (PTSD) PTSD Wistar rats HIP "CP-154,526 treatment" downregulated 28944448 1294 Rat rno-miR-16 miRNA sitagliptin renal interstitial inflammatory type II diabetic Goto-Kakizaki (GK) sitagliptin treatment upregulated 28652790 1295 Rat rno-miR-16 miRNA cronobacter sakazakii septicemia amygdala cronobacter sakazakii treatment upregulated 26388777 1296 Rat rno-miR-16 miRNA perfluorooctane sulfonic acid (PFOS) perfluorooctane sulfonate (PFOS)-induced toxic action rat liver tissue dams received 3.2 mg/kg PFOS in their feed from gestational day 1 (GD1) to postnatal day 7 (PND 11) treatment different expression 24420840 1297 Rat rno-miR-16-3p miRNA artemisinin (ART) ventricular arrhythmias (VA) transverse aortic constriction (TAC) surgery treated rats left ventricle (LV) tissues artemisinin (ART) treatment upregulated 30595983 1298 Rat rno-miR-16-5p miRNA isoproterenol acute cardiac injury blood isoproterenol treatment upregulated 27605421 1299 Rat rno-miR-16-5p miRNA "2,3,5,6-tetramethylpyrazine (TMP)" creeclampsia (PE) trophoblast cells of placental tissue of PE rats "2,3,5,6-tetramethylpyrazine (TMP) treatment" TMP inhibits trophoblast cell autophagy and promotes its viability and migration in PE rat model through regulating the miR-16-5p/IGF-2 axis. 33112793 1300 Rat rno-miR-16-5p miRNA octreotide (OCT) neuroendocrine tumors INS-1 cells octreotide treatment upregulated 33045023 1301 Rat rno-miR-17 miRNA ethanol (EtOH) acute gastric mucosal injury gastric tissues?of rat oral administration of ethanol downregulated 23830200 1302 Rat rno-miR-17 miRNA butyrylated high-amylose maize starch (HAMSB) colorectal cancer (CRC) high-protein meat diet (HPM) fed rat colonic tissue butyrylated high-amylose maize starch (HAMSB) feed downregulated 31052187 1303 Rat rno-miR-17 miRNA high-amylose potato starch (HAPS) colorectal cancer (CRC) high-protein meat diet (HPM) fed rat colonic tissue high-amylose potato starch (HAPS) feed downregulated 31052187 1304 Rat rno-miR-17 miRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) Wistar rats left ventricle (LV) STZ treatment upregulated 28199183 1305 Rat rno-miR-17 miRNA resveratrol cardiac fibrosis cardiac fibroblasts (CFs) resveratrol (Res) treatment "Resveratrol decreased the levels of miR-17,in TGF- ¦Â1-treated CFs" 30648109 1306 Rat rno-miR-17 miRNA high fat diet (HFD) and streptozotocin (STZ) nonalcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD); streptozotocin (STZ) treatment downregulated 30338914 1307 Rat rno-miR-17 miRNA "1,3,5-tris-4-propyl-1H-pyrazole" spinal cord injury (SCI) VSC4.1 motoneurons ER agonists treatment upregulated 24157932 1308 Rat rno-miR-17 miRNA streptozocin (STZ) type 2 diabetes mellitus (T2DM) retina tissues streptozotocin (STZ) treatment upregulated 30170066 1309 Rat rno-miR-17-1 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 1310 Rat rno-miR-17-3p miRNA dexamethasone (DEX) ischemia/reperfusion (I/R) injury H9c2 cells dexamethasone (DEX) treatment "A concentration of 0.1-10 ?mol/l Dex attenuated H/R injury, which was accompanied by increased miR-17-3p levels." 32742334 1311 Rat rno-miR-17-3p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 31730378 1312 Rat rno-miR-17-3p miRNA rosuvastatin myocardial ischemia/reperfusion (I/R) injury (MIRI) oxygen-glucose deprivation/reoxygenation (OGD/R) induced H9C2 cells Rosuvastatin (RS) treatment upregulated 31730378 1313 Rat rno-miR-17-3p miRNA perfluorooctane sulfonic acid (PFOS) perfluorooctane sulfonate (PFOS)-induced toxic action rat liver tissue dams received 3.2 mg/kg PFOS in their feed from gestational day 1 (GD1) to postnatal day 7 (PND 9) treatment different expression 24420840 1314 Rat rno-miR-17-5p miRNA insert a cannula connected with a saline container into the anterior chamber acute ocular hypertension (AOH) adult albino rats retinal ganglion cells (RGCs) and microglial cells insert a cannula connected with a saline container into the anterior chamber downregulated 27535721 1315 Rat rno-miR-17-5p miRNA H2O2 cardiovascular disease (CVD) H9c2 cells H2O2 treatment upregulated 33350543 1316 Rat rno-miR-17-5p miRNA hypoxia glial scars DI TNC1 cells hypoxia treatment upregulated 27460735 1317 Rat rno-miR-17-5p miRNA H2O2 ischemia/reperfusion (I/R) injury neonatal rat ventricular cardiomyocytes (NRVCs) oxidative stress treatment upregulated 25200830 1318 Rat rno-miR-17-5p miRNA hypoxia ischemic acute kidney injury rat kidney proximal tubular cell (RPTC) line hypoxia treatment upregulated 27622990 1319 Rat rno-miR-17-5p miRNA carbon tetrachloride (CCl4) liver fibrosis hepatic stellate cell (HSC) CCl4 treatment upregulated 25915722 1320 Rat rno-miR-17-5p miRNA Salvianolic acid B (Sal B) liver fibrosis hepatic stellate cell (HSC) Salvianolic acid B (Sal B) treatment downregulated 26637809 1321 Rat rno-miR-17-5p miRNA diosmin (Dios) oxidative stress rats 100 mg¡¤(kg body mass)-1¡¤day-1 (per oral) of Dios downregulated 28177765 1322 Rat rno-miR-17-5p miRNA ionizing radiation (IR) oxidative stress liver tissues overall dose of 12 Gy on 6 fractions of 2 Gy each upregulated 28177765 1323 Rat rno-miR-17-5p miRNA X-rays radiation-induced skin injury rats irradiated skin 45-Gy electron beam treatment downregulated 24447893 1324 Rat rno-miR-17-5p miRNA beta-phenethyl isothiocyanate (PEITC) sciatic nerve conditioning injury Primary Sensory Neurons beta-phenethyl isothiocyanate (PEITC) treatment downregulated 29877111 1325 Rat rno-miR-181 miRNA "2,5-hexanedione (HD)" "2,5-hexanedione (HD) toxicity" spinal cord tissues "2,5-hexanedione (HD) treatment" upregulated 31760062 1326 Rat rno-miR-181 miRNA DF3016A ischemic neuroinflammatory injury OGD/R treated primary cultured neurons oxygen-glucose deprivation-reoxygenation (OGD/R) treatment downregulated 30953275 1327 Rat rno-miR-181 miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic neuroinflammatory injury Primary Cultured neurons oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 30953275 1328 Rat rno-miR-181 miRNA angiotensin II (Ang II) renal fibrosis NRK49F cells angiotensin II (Ang II) treatment downregulated 30816527 1329 Rat rno-miR-181a miRNA ethanol (EtOH) acute gastric mucosal injury gastric tissues?of rat oral administration of ethanol downregulated 23830200 1330 Rat rno-miR-181a miRNA adriamycin (ADR) anthracycline-induced cardiomyocyte apoptosis "rat myocardial cell line, H9c2, and primary cardiomyocytes" adriamycin (ADR) treatment upregulated 29849870 1331 Rat rno-miR-181a miRNA propofol (PPF) anthracycline-induced cardiomyocyte apoptosis "Adriamycin? (ADM)-treated rat myocardial cell line, H9c2, and primary cardiomyocytes" propofol treatment downregulated 29849870 1332 Rat rno-miR-181a miRNA H2O2 antiapoptotic mesenchymal stem cells (MSCs) H2O2 treatment upregulated 26283227 1333 Rat rno-miR-181a miRNA GW0742 astrocytic injury rat hippocampal astrocytes GW0742 upregulated 27789312 1334 Rat rno-miR-181a miRNA sevoflurane (SEV) cerebral ischemia/reperfusion (I/R) injury "primary cortical neurons after OGD, rat brain after MCAO" sevoflurane (SEVO) treatment downregulated 31170386 1335 Rat rno-miR-181a miRNA high glucose (HG) diabetic cardiomyopathy (DCM) cardiomyocytes high glucose treatment upregulated 27221738 1336 Rat rno-miR-181a miRNA TGF-¦Â diabetic nephropathy (DN) Rat glomerular mesangial cells TGF¦Â treatment upregulated 29397070 1337 Rat rno-miR-181a miRNA dapagliflozin drug-induced acute kidney injury (DIKI) rat kidney tissues Dapagliflozin (DAPA) treatment upregulated 31075409 1338 Rat rno-miR-181a miRNA dapagliflozin drug-induced acute kidney injury (DIKI) GNT-treated rat kidney tissues Dapagliflozin (DAPA) treatment downregulated 31075409 1339 Rat rno-miR-181a miRNA gentamicin drug-induced acute kidney injury (DIKI) rat kidney tissues gentamicin (GNT) treatment upregulated 31075409 1340 Rat rno-miR-181a miRNA pentylenetetrazol (PTZ) epilepsy hippocampal tissues pentylenetetrazol (PTZ) treatment upregulated 26722477 1341 Rat rno-miR-181a miRNA perinatal nicotine health effects of E-cigarette and other novel electronic nicotine delivery systems (ENDS) heart tissues perinatal nicotine exposure (PNE) treatment PNE could induce a reprogramming of cardiac miR-181a expression/DNA methylation pattern 33052248 1342 Rat rno-miR-181a miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment upregulated 27041227 1343 Rat rno-miR-181a miRNA resveratrol cardiac fibrosis cardiac fibroblasts (CFs) resveratrol (Res) treatment Resveratrol decreased the levels of miR-181a in TGF- ¦Â1-treated CFs 30648109 1344 Rat rno-miR-181a miRNA abdominal aortic coarctation cardiac hypertrophy rats cardiac tissues abdominal aortic coarctation treatment downregulated in cardiac tissues 29243791 1345 Rat rno-miR-181a miRNA H2O2 oxidative stress H9c2 rat cardiomyocyte cell line H2O2 treatment upregulated 24683439 1346 Rat rno-miR-181a miRNA retinal toxicant pan-CDK inhibitors retinal toxicity rats in renal a single intravitreal (IVT) injection treatment upregulated 24114799 1347 Rat rno-miR-181a miRNA hesperidin testicular toxicity testicular hesperidin (HSP) treatment upregulated 32050098 1348 Rat rno-miR-181a/b-5p miRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) lung tissues monocrotaline (MCT) treatment downregulated 31637717 1349 Rat rno-miR-181a/b-5p miRNA tumor necrosis factor alpha (TNF-¦Á) pulmonary arterial hypertension (PAH) primary rat pulmonary arterial endothelial cells (rPAECs) tumor necrosis factor alpha (TNF-¦Á) treatment downregulated 31637717 1350 Rat rno-miR-181a-2-3p miRNA amyloid-¦Â (A¦Â) 1-42 Alzheimer's disease (AD) hippocampus amyloid ¦Â1-42?(A¦Â) treatment upregulated 29706607 1351 Rat rno-miR-181a-5p miRNA lipopolysaccharide (LPS) acute respiratory distress syndrome (ARDS) lung tissues lipopolysaccharide (LPS) treatment downregulated 33407436 1352 Rat rno-miR-181a-5p miRNA methamphetamine (METH) addiction nucleus accumbens tissues Methamphetamine treatment dysregulated 28681200 1353 Rat rno-miR-181a-5p miRNA streptozocin (STZ) diabetes mellitus (DM) rat insulinoma (INS-1) cells streptozotocin (STZ) treatment Silencing of lncRNA PVT1 ameliorates streptozotocin-induced pancreatic ¦Â cell injury and enhances insulin secretory capacity by regulating miR-181a-5p 32758099 1354 Rat rno-miR-181a-5p miRNA liraglutide endothelial dysfunction aortic endothelial in diabetic rats liraglutide treatment downregulated 30863684 1355 Rat rno-miR-181a-5p miRNA hypoxia hypoxic/ischemic injury Male Sprague Dawley rats "were exposed to hypoxia (9.5-10% O2) for 1, 5, or 10 days" upregulated 29262398 1356 Rat rno-miR-181a-5p miRNA doxorubicin (DOX) ischemia/reperfusion (I/R) injury rats cardiomyocytes doxorubicin treatment downregulated 27919821 1357 Rat rno-miR-181a-5p miRNA high mobility group box-1 protein (HMGB1) sepsis rats dendritic cell (DC) HMGB1 upregulated 28947753 1358 Rat rno-miR-181a-5p miRNA CXCR4 agonist AMD3100 severe acute pancreatitis (SAP) Severe acute pancreatitis (SAP) rats pancreas and serum CXCR4 agonist AMD3100 treatment downregulated 31654716 1359 Rat rno-miR-181a-5p miRNA Sodium taurocholate Severe acute pancreatitis (SAP) pancreas and serum Sodium taurocholate treatment downregulated 31654716 1360 Rat rno-miR-181a-5p miRNA lithium chloride and pilocarpine temporal lobe epilepsy (TLE) hippocampus lithium-pilocarpine treatment miR-181a-5p was increased in the hippocampus. 32461588 1361 Rat rno-miR-181b miRNA angiotensin II (Ang II) cardiac fibrosis and hypertension cardiac fibroblasts (CFs) of rats angiotensin II (Ang II) treatment downregulated 23007623 1362 Rat rno-miR-181b miRNA kainic acid (KA) epilepsy hippocampus of KA-induced juvenile epileptic rats kainic acid (KA) treatment downregulated 29808547 1363 Rat rno-miR-181b miRNA magnesium-free extracellular fluid epilepsy hippocampal neurons magnesium-free treatment MiR-181b suppressed the progression of epilepsy via regulation of RASSF1A and lncRNA ZNF883. 32655808 1364 Rat rno-miR-181b miRNA gleditsia sinensis extract (GSE) hepatocellular carcinoma (HCC) HCC liver Gleditsia sinensis extract (GSE) treatment upregulated 30940289 1365 Rat rno-miR-181b miRNA ¦Â-ionone (¦ÂI) hepatocellular carcinoma (HCC) rats hepatocyte ¦ÂI (16 mg/100 g body weight) treatment "upregulated(miR-122 , miR-34a) ;downregulated (miR-181b , miR-708)" 27061051 1366 Rat rno-miR-181b miRNA hypoxia hypertensive disorders complicating pregnancy (HDCP) primary cardiomyocytes hypoxia treatment downregulated 28912851 1367 Rat rno-miR-181b miRNA carbon tetrachloride (CCl4) liver fibrosis male Sprague¨CDawley (180¨C220 g) rats CCl4 treatment upregulated 25148875 1368 Rat rno-miR-181b miRNA 1-methyl-4-phenylpyridinium (MPP+) parkinson's disease (PD) PC-12 cells 1-methyl-4- phenylpyridinium iodide(MPP +) treatment The expression of miR-181b was downregulated by the change in MPP+ concentration. 29608948 1369 Rat rno-miR-181b miRNA panax notoginseng saponins (PNS) severe acute pancreatitis (SAP) taurocholate-induced severe acute pancreatitis (SAP) rats pancreas tissues Panax notoginseng saponins treatment upregulated 29402262 1370 Rat rno-miR-181b miRNA taurocholate severe acute pancreatitis (SAP) pancreas tissues taurocholate treatment downregulated 29402262 1371 Rat rno-miR-181b miRNA silicon dioxide (SiO2) silicosis fibrotic lungs silicon dioxide (SiO2) treatment downregulated 26239160 1372 Rat rno-miR-181b miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment downregulated 21094214 1373 Rat rno-miR-181b-1 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 1374 Rat rno-miR-181b-1-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 1375 Rat rno-miR-181b-3p miRNA hyaluronic acid 35 (HA35) ethanol-induced liver and intestinal injury Kupffer cells isolated from ethanol-fed rats HA35 for 5 h upregulated 28257601 1376 Rat rno-miR-181b-5p miRNA earle's balanced salt solution (EBSS) autophagy H9c2 cardiomyocytes and neonatal rat ventricular myocytes (NRVMs) "H9c2 cardiomyocytes and neonatal rat ventricular myocytes (NRVMs) were glucose-starved in Earle's Balanced Salt Solution (EBSS) for different periods of time (0, 2, 4, 6 and 8 h)" downregulated 30431062 1377 Rat rno-miR-181b-5p miRNA glucose starvation cardiomyocyte autophagy H9c2 cardiomyocytes and neonatal rat ventricular myocytes (NRVMs) glucose-starved in Earle's Balanced Salt Solution (EBSS) induce downregulated 30431062 1378 Rat rno-miR-181b-5p miRNA monocrotaline (MCT) epithelial-mesenchymal transition (EMT) rat pulmonary arterial monocrotaline (MCT) treatment downregulated 31734320 1379 Rat rno-miR-181b-5p miRNA "TNF-¦Á, TGF¦Â1 and IL-1¦Â in combination" epithelial-mesenchymal transition (EMT) primary rat pulmonary arterial endothelial cells (rPAECs) "TNF-¦Á, TGF¦Â1 and IL-1¦Â in combination treatment" downregulated 31734320 1380 Rat rno-miR-181b-5p miRNA hypoxia ischemic heart disease (IHD) H9C2 myocardial cells hypoxia induce upregulated 31297863 1381 Rat rno-miR-181b-5p miRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) rat pulmonary arterial monocrotaline (MCT) treatment downregulated 31734320 1382 Rat rno-miR-181b-5p miRNA "TNF-¦Á, TGF¦Â1 and IL-1¦Â in combination" pulmonary arterial hypertension (PAH) primary rat pulmonary arterial endothelial cells (rPAECs) "TNF-¦Á, TGF¦Â1 and IL-1¦Â in combination treatment" downregulated 31734320 1383 Rat rno-miR-181b-5p miRNA glucocorticoid (GC) respiratory distress syndrome lung Glucocorticoids treatment downregulated 26997989 1384 Rat rno-miR-181b-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 1385 Rat rno-miR-181b-5p miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC-12 cells lipopolysaccharide (LPS) treatment ?Bioinformatics prediction and luciferase reporter assay demonstrated that miR-181b-5p could directly bind to SNHG14. 33791006 1386 Rat rno-miR-181c miRNA IL-6 apoptosis INS-1 beta cells IL-6 treatment downregulated 30974824 1387 Rat rno-miR-181c miRNA valproic acid (VPA) autism spectrum disorder (ASD) amygdala valproic acid treatment upregulated 25986729 1388 Rat rno-miR-181c miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia injury (CII) primary hippocampal neurons oxygen-glucose deprivation and reoxygenation (OGD/R) treatment miR-181c was significantly decreased in OGD/reoxygenation-treated hippocampal neurons. 32213240 1389 Rat rno-miR-181c miRNA bilateral common carotid artery occlusion (2-VO) chronic cerebral hypoperfusion (CCH) rats bilateral common carotid artery?occlusion (2VO) induce downregulated 27933582 1390 Rat rno-miR-181c miRNA ischemia/hypoxia (IH) chronic cerebral hypoperfusion (CCH) hippocampus ischemia/hypoxia treatment downregulated 27933582 1391 Rat rno-miR-181c miRNA H2O2 craniofacial defect Bone mesenchymal stem cell (BMSC) H2O2 treatment downregulated 33111200 1392 Rat rno-miR-181c miRNA H2O2 craniofacial defect reconstruction Bone mesenchymal stem cell (BMSC) hydrogen peroxide (H2O2) treatment downregulated 31578723 1393 Rat rno-miR-181c miRNA hypoxia/reoxygenation (H/R) doxorubicin (DOX)-induced cardiotoxicity H9C2 cells hypoxia /reoxygenation (H/R) treatment MiR-181c protects cardiomyocyte injury by preventing cell apoptosis through PI3K/Akt signaling pathway 32968640 1394 Rat rno-miR-181c miRNA methamphetamine (METH) intestinal barrier dysfunction IEC-6 cells (rat small intestine epithelial cells) Methamphetamine treatment downregulated 31862507 1395 Rat rno-miR-181c miRNA H2O2 oxidative stress Bone mesenchymal stem cells (BMSC) H2O2 treatment downregulated 31466503 1396 Rat rno-miR-181c miRNA 1-methyl-4-phenylpyridinium (MPP+) parkinson's disease (PD) PC12 1-methyl-4-phenylpyridinium (MPP+) treatment upregulated 28770951 1397 Rat rno-miR-181c miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment downregulated 21094214 1398 Rat rno-miR-181c-3p miRNA oxygen glucose deprivation (OGD) ischemic brain injury primary cortical neurons?and secreted exosomes oxygen and glucose deprivation (OGD) treatment downregulated 31665717 1399 Rat rno-miR-181c-5p miRNA aflatoxin B1 (AFB1) hepatocellular carcinoma (HCC) F344 rats liver tissues aflatoxin B1 (AFB3) treatment upregulated 28218475 1400 Rat rno-miR-181c-5p miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) ?H9C2 cells hypoxia induce upregulated 31178952 1401 Rat rno-miR-181d-5p miRNA Jianpi Xiaoke (JPXK) type 2 diabetes mellitus (T2DM) rat Jianpi Xiaoke (JPXK) treatment upregulated 33456489 1402 Rat rno-miR-182 miRNA hypoxia acute kidney injury (AKI) NRK-52E cells hypoxia induce upregulated 29733821 1403 Rat rno-miR-182 miRNA high fat diet (HFD) aging-related non-alcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD) feed downregulated 31899128 1404 Rat rno-miR-182 miRNA vitamin D3 arterial calcification rat calcified arterial tissues vitamin D3 treatment downregulated 29196163 1405 Rat rno-miR-182 miRNA vitamin D3 and ¦Â-glycerophosphate arterial calcification Sprague Dawley (SD) rats calcified arterial tissues vitamin D3 and ¦Â-glycerophosphate treatment downregulated in calcified arterial tissues 29196163 1406 Rat rno-miR-182 miRNA ¦Â-glycerophosphate (¦Â-GP) arterial calcification vascular smooth muscle cells (VSMCs) ¦Â-glycerophosphate treatment downregulated 29196163 1407 Rat rno-miR-182 miRNA hypoxia cyanotic congenital heart disease (CCHD) H9c2 cells hypoxia induce downregulated 30107165 1408 Rat rno-miR-182 miRNA streptozocin (STZ) diabetic retinopathy (DR) ?retinas?tissues streptozotocin (STZ) treatment upregulated 22156553 1409 Rat rno-miR-182 miRNA aflatoxin B1 (AFB1) epatocarcinogenesis serum aflatoxin (AFB1 ) treatment upregulated 31373075 1410 Rat rno-miR-182 miRNA fluorine combined with aluminum (FA) fluorine combined with aluminum (FA)-induced developmental neurotoxicity hippocampi fluorine combined with aluminum (FA) treatment upregulated 30033483 1411 Rat rno-miR-182 miRNA rapid ventricular pacing heart failure (HF) rat heart tissues rapid ventricular pacing induce treatment downregulated 31210325 1412 Rat rno-miR-182 miRNA adreno-cortico-tropic-hormone (ACTH) hormonal regulation adrenals?tissues adreno-cortico-tropic-hormone (ACTH) treatment upregulated 24205079 1413 Rat rno-miR-182 miRNA estradiol-17¦Â (E2) hormonal regulation adrenals?tissues estradiol-17¦Â (E2) treatment upregulated 24205079 1414 Rat rno-miR-182 miRNA hypoxia hypoxic/ischemic injury Male Sprague Dawley rats "were exposed to hypoxia (9.5-10% O2) for 1, 5, or 10 days" downregulated 29262398 1415 Rat rno-miR-182 miRNA schistosomiasis japonica liver fibrosis hepatic fibrosis tissues Schistosomiasis japonica infection treatment upregulated 29323718 1416 Rat rno-miR-182 miRNA heat stress lung cancer lung Heating System 2.2 (THS2.2) treatment downregulated 27866933 1417 Rat rno-miR-182 miRNA ellagic acid (EA) breast cancer female rat mammary tissue ellagic acid treatment "ellagic acid, which inhibited E2-induced mammary tumorigenesis in our previous study, reversed the dysregulation of miR-375, miR-206, miR-182, miR-122, miR-127 and miR-183 detected with E2treatment" 23791885 1418 Rat rno-miR-182 miRNA fluorine combined with aluminum (FA) neurotoxicity hippocampi in the offspring of rats fluorine combined with aluminum (FA) exposure upregulated 30033483 1419 Rat rno-miR-182 miRNA oxymatrine nonalcoholic fatty liver disease (NAFLD) liver tissues oxymatrine treatment upregulated 32679144 1420 Rat rno-miR-182 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment upregulated 27910957 1421 Rat rno-miR-182 miRNA glucocorticoid (GC) respiratory distress syndrome lung Glucocorticoids treatment downregulated 26997989 1422 Rat rno-miR-182 miRNA retinal toxicant pan-CDK inhibitors retinal toxicity rats in renal a single intravitreal (IVT) injection treatment upregulated 24114799 1423 Rat rno-miR-182 miRNA activated protein C(APC) sepsis rats blood and liver tissue activated protein C treatment aPC treatment coordinates beneficial cytoprotective effects during sepsis by modulating miRNA expression 22940033 1424 Rat rno-miR-182 miRNA colesevelam zucker diabetic fatty (ZDF) liver tissues colesevelam treatment upregulated 30160993 1425 Rat rno-miR-182-5p miRNA ganoderic acid A (GAA) hypoxia-induced cardiac dysfunctions H9c2 cells Ganoderic acid A (GAA) treatment GAA obviously enhanced the expression level of miR-182-5p in H9c2 cells. 30415259 1426 Rat rno-miR-182-5p miRNA diethylnitrosamine (DEN) liver fibrosis liver tissues diethylnitrosamine (DEN) treatment upregulated 29236317 1427 Rat rno-miR-182-5p miRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia induce upregulated 29671338 1428 Rat rno-miR-182-5p miRNA aldosterone osteoporosis Osteoporosis (OP) rats left femurs alendronate treatment downregulated 30413613 1429 Rat rno-miR-182-5p miRNA palmitate type 2 diabetes mellitus (T2DM) INS-1 cells palmitate (Pal) treatment upregulated 30546417 1430 Rat rno-miR-183 miRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia treatment downregulated 28731278 1431 Rat rno-miR-183 miRNA hypoxia acute myocardial infarction (AMI) rat cardiomyocyte-drived H9c2 cells hypoxia downregulated 28731278 1432 Rat rno-miR-183 miRNA streptozocin (STZ) diabetic retinopathy (DR) ?retinas?tissues streptozotocin (STZ) treatment upregulated 22156553 1433 Rat rno-miR-183 miRNA gleditsia sinensis extract (GSE) hepatocellular carcinoma (HCC) HCC liver Gleditsia sinensis extract (GSE) treatment upregulated 30940289 1434 Rat rno-miR-183 miRNA adreno-cortico-tropic-hormone (ACTH) hormonal regulation adrenals?tissues adreno-cortico-tropic-hormone (ACTH) treatment upregulated 24205079 1435 Rat rno-miR-183 miRNA estradiol-17¦Â (E2) hormonal regulation adrenals?tissues estradiol-17¦Â (E2) treatment upregulated 24205079 1436 Rat rno-miR-183 miRNA ellagic acid (EA) breast cancer female rat mammary tissue ellagic acid treatment "ellagic acid, which inhibited E2-induced mammary tumorigenesis in our previous study, reversed the dysregulation of miR-375, miR-206, miR-182, miR-122, miR-127 and miR-183 detected with E2treatment" 23791885 1437 Rat rno-miR-183 miRNA retinal toxicant pan-CDK inhibitors retinal toxicity rats in renal a single intravitreal (IVT) injection treatment upregulated 24114799 1438 Rat rno-miR-183 miRNA colesevelam zucker diabetic fatty (ZDF) liver tissues colesevelam treatment upregulated 30160993 1439 Rat rno-miR-183 miRNA dexamethasone (DEX) hormonal regulation adrenals?tissues dexamethasone (DEX) treatment upregulated 24205079 1440 Rat rno-miR-183-3p miRNA vagus nerve stimulation (VNS) chronic systolic heart failure (CSHF) heart tissues vagus nerve stimulation (VNS) stimulation treatment upregulated 31629817 1441 Rat rno-miR-183-3p miRNA vagus nerve stimulation (VNS) chronic systolic heart failure (CSHF) heart tissues vagus nerve stimulation (VNS) treatment MicroRNA-183-3p upregulated by vagus nerve stimulation mitigates chronic systolic heart failure via the reduction of BNIP3L-mediated autophagy 31629817 1442 Rat rno-miR-183-5p miRNA chronic unpredictable mild stress (CUMS) depression hippocampus tissues chronic unpredictable mild stressed (CUMS) treatment upregulated 28083819 1443 Rat rno-miR-183-5p miRNA hronic unpredictable mild stressed (CUMS) depression rats hippocampal tissues stimulated daily with randomly applied mild stressors from among 14 different mild stressors upregulated 28083819 1444 Rat rno-miR-183-5p miRNA diethylnitrosamine (DEN) liver fibrosis liver tissues diethylnitrosamine (DEN) treatment upregulated 29236317 1445 Rat rno-miR-183-5p miRNA anoxia/reoxygenation (A/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells anoxia/reoxygenation (A/R) treatment downregulated 31618500 1446 Rat rno-miR-183-5p miRNA oxymatrine nonalcoholic fatty liver disease (NAFLD) liver tissues oxymatrine treatment upregulated 32679144 1447 Rat rno-miR-183-5p miRNA N-methyl-N-nitrosourea (MNU) retinal lesions serum N-methyl-N-nitrosourea (MNU) treatment "MNU at 50?mg/kg induced photoreceptor cell death, with elevation in serum miR-183-5p levels." 30336191 1448 Rat rno-miR-183-5p miRNA N-methyl-N-nitrosourea (MNU) retinal toxicity serum N-methyl-N-nitrosourea (MNU) treatment upregulated 30336191 1449 Rat rno-miR-184 miRNA palmitic acid (PA) diabetic cardiomyopathy (DCM) H9c2 cells palmitic acid treatment The expression of miR-184 was significantly decreased in H9c2 cardiomyoblast treated by palmitic acid 32229289 1450 Rat rno-miR-184 miRNA hypoxia hypoxic/ischemic injury Male Sprague Dawley rats "were exposed to hypoxia (9.5-10% O2) for 1, 5, or 10 days" upregulated 29262398 1451 Rat rno-miR-184 miRNA cisplatin (DDP) kidney damage male Wistar rats cisplatin treatment upregulated 24880025 1452 Rat rno-miR-184 miRNA H2O2 myocardial infarction (MI) H9c2 cells H2O2 treatment MiR-184 expression was significantly increased in H2O2-induced H9c2 cell injury model. 33215444 1453 Rat rno-miR-184 miRNA phthalate mixture prostate development Pregnant females filial generation rat prostate Pregnant females were divided into 4 groups and orally dosed daily from GD10 to PND21 with corn oil (Control:C) or the phthalate mixture at three doses (20?¦Ìg/kg/d:T1; 200?¦Ìg/kg/d:T2; 200?mg/kg/d:T3). treatment upregulated 31199487 1454 Rat rno-miR-184 miRNA angiotensin II (Ang II) renal fibrosis NRK49F cells angiotensin II (Ang II) treatment upregulated 30536131 1455 Rat rno-mir-184 miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 1456 Rat rno-miR-184 miRNA dextran sodium sulfate (DSS) ulcerative colitis (UC) Sprague-Dawley (SD) rats colon tissues in the colon tissues dextran sulfate sodium (DSS) upregulated( miR-149-5p) downregulated (miR-184) in the colon tissues in the colon tissues 28246536 1457 Rat rno-miR-184 miRNA herb-partitioned moxibustion ulcerative colitis (UC) UC rats colon tissues herb-partitioned moxibustion upregulated 28246536 1458 Rat rno-miR-185 miRNA tunicamycin (TM) or thapsigargin (TG) cardiomyocyte apoptosis neonatal rat ventricular myocytes (NRVMs) neonatal rat ventricular myocytes (NRVMs) treatment downregulated 26521941 1459 Rat rno-miR-185 miRNA rotenone (ROT) parkinson's disease (PD) rats substantia nigra (SN) and striatum (ST) tissues rotenone treatment downregulated 31814881 1460 Rat rno-miR-186 miRNA tumor necrosis factor alpha (TNF-¦Á) apoptosis rat primary cardiomyocytes 10¦Ìg/ml or 50¦Ìg/ml TNF¦Á stimulation for 24h treatment downregulated 28233577 1461 Rat rno-miR-186 miRNA GYKI-52466 and MK-801 homeostatic synaptic scaling hippocampal neurons Blockade of AMPARs and NMDARs with 50 ¦ÌM GYKI-52466 and 10 ¦ÌM MK-801 for 24h synaptic activity blockade persistently down-regulates miR-186-5p. 30808806 1462 Rat rno-miR-187 miRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) Wistar rats left ventricle (LV) STZ treatment upregulated 28199183 1463 Rat rno-miR-187 miRNA IL-10 epilepsy hippocampal tissues IL-10 treatment downregulated 26696826 1464 Rat rno-miR-187-3p miRNA doxorubicin (DOX) cardiotoxicity H9c2 cells Doxorubicin (DOX) treatment miR-187-3p inhibitor significantly reduced PVT1-knockdown H9c2 cell viability and promoted apoptosis 31786333 1465 Rat rno-miR-187-3p miRNA doxorubicin (DOX) doxorubicin (DOX)-induced cardiotoxicity H9c2 cells doxorubicin (DOX) treatment "ncRNA PVT1 adsorbs miR-187-3p by sponge action, reducing miR-187-3p levels." 31786333 1466 Rat rno-miR-188 miRNA iodixanol contrast-induced acute kidney injury (CIAKI) rat renal tissues iodixanol treatment upregulated 31555692 1467 Rat rno-miR-188 miRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) Wistar rats left ventricle (LV) STZ treatment upregulated 28199183 1468 Rat rno-miR-188 miRNA ethylene glycol monomethyl ether (EGME) hyperglycemia ?testicle of rat Ethylene glycol monomethyl ether (EGME) treatment "miR-449a and miR-92a decreased obviously and, miR-320, miR-134 and miR-188 increased" 22008535 1469 Rat rno-miR-188-3p miRNA sevoflurane (SEV) cognitive impairment rat brain tissues sevoflurane treatment upregulated 29344658 1470 Rat rno-miR-188-5p miRNA amyloid-¦Â (A¦Â) 1-42 Alzheimer's disease (AD) primary hippocampal neuron amyloid ¦Â1-42?(A¦Â) treatment downregulated 27708404 1471 Rat rno-miR-18a miRNA hypoxia acute myocardial infarction (AMI) cardiac tissues and H9c2 cells hypoxia induce upregulated 31168354 1472 Rat rno-miR-18a miRNA (E)-1-(4'-aminophenyl)-3-phenylprop-2-en-1-one (APE) breast cancer plasma (E)-1-(4'-aminophenyl)-3-phenylprop-2-en-1-one (APE) treatment APE can decrease miR-18a and MMP-9 expressions and increase Dicer1 expression in rat mammary cancer. 32458624 1473 Rat rno-miR-18a miRNA blueberry breast cancer estrogen-mediated rats breast cancer blueberry-supplemented diet treatment upregulated 24245576 1474 Rat rno-miR-18a miRNA dexamethasone (DEX) depression prefrontal cortex and hippocampus of adolescent rats dexamethasone (DEX) treatment upregulated 30469088 1475 Rat rno-miR-18a miRNA dexamethasone (DEX) depression prefrontal cortex and hippocampus of adolescent rats dexamethasone (DEX) treatment upregulated 30469088 1476 Rat rno-miR-18a miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment downregulated 27041227 1477 Rat rno-miR-18a miRNA hypoxia hypoxia-induced injury neuronal pheochromocytoma (PC)-12 cells hypoxia treatment downregulated 319666702 1478 Rat rno-miR-18a miRNA isoflurane oxidative stress H9c2 cells Isoflurane treatment downregulated 29627934 1479 Rat rno-miR-18a miRNA nanosized SiO2 pulmonary injury liver tissues nanosized SiO2 treatment upregulated 27689473 1480 Rat rno-miR-18a-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia injury (CII) PC12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 32815784 1481 Rat rno-miR-19 miRNA TGF-¦Â1 renal fibrosis NRK-52E cells TGF-¦Â1 treatment miR-19 was significantly increased in cells treated with TGF-¦Â1 32355512 1482 Rat rno-miR-190 miRNA fish oil and pectin colorectal cancer (CRC) colon tissue of rats corn oil ¡À fish oil with pectin ¡À cellulose upregulated 21406606 1483 Rat rno-miR-190 miRNA fentanyl fentanyl toxicity rat primary hippocampal neuron cultures fentanyl downregulated 20457614 1484 Rat rno-miR-190 miRNA 4-vinylcyclohexene diepoxide (VCD) premature ovarian failure (POF) ovarian 4-vinylcyclohexene diepoxide (VCD) tretament upregulated 24188450 1485 Rat rno-miR-190 miRNA fentanyl smooth muscle cell differentiation rat hippocampal neurons fentanyl treatment downregulated 19854889 1486 Rat rno-miR-190a miRNA dichlorodiphenyltrichloroethane (DDT) dichlorodiphenyltrichloroethane (DDT) exposure "liver, uterus, ovaries and mammary gland of female Wistar rats" dichlorodiphenyltrichloroethane (DDT) exposure upregulated 30421125 1487 Rat rno-miR-190a miRNA isoflurane and sevoflurane postoperative cognitive dysfunction (POCD) Wistar rats hippocampus exposed to isoflurane and sevoflurane for 2 or 4h downregulated in the hippocampus 28669717 1488 Rat rno-miR-190b miRNA dichlorodiphenyltrichloroethane (DDT) dichlorodiphenyltrichloroethane (DDT) exposure "liver, uterus, ovaries and mammary gland of female Wistar rats" dichlorodiphenyltrichloroethane (DDT) exposure upregulated 30421125 1489 Rat rno-miR-190b miRNA isoflurane and sevoflurane postoperative cognitive dysfunction (POCD) Wistar rats hippocampus exposed to isoflurane and sevoflurane for 2 or 4h downregulated in the hippocampus 28669717 1490 Rat rno-miR-1912-3p miRNA fluorine combined with aluminum (FA) fluorine combined with aluminum (FA)-induced developmental neurotoxicity hippocampi fluorine combined with aluminum (FA) treatment upregulated 30033483 1491 Rat rno-miR-191a-5p miRNA paradoxical sleep deprivation (PSD) cognitive impairment Hippocampal tissues paradoxical sleep deprivation (PSD) induce treatment upregulated 31279826 1492 Rat rno-miR-191b miRNA hypoxia stroke middle cerebral artery occlusion (MCAO) Sprague-Dawley rat middle cerebral artery occlusion (MCAO) treatment upregulated 29113076 1493 Rat rno-miR-192 miRNA connective tissue growth factor (CTGF) gastric cancer (GC) NRK-52E cells CTGF treatment downregulated 20393144 1494 Rat rno-miR-192 miRNA TGF-¦Â gastric cancer (GC) NRK-52E cells TGF-¦Â treatment downregulated 20393144 1495 Rat rno-miR-192 miRNA ischemia/reperfusion (I/R) acute kidney injury (AKI) rats plasma ischemia/reperfusion (I/R) treatment upregulated by fourfold in the plasma and downregulatedd by about 40% in the kidney 28035621 1496 Rat rno-miR-192 miRNA carbon tetrachloride (CCl4) acute liver failure (ALF) rats CCl4 treatment upregulated 28616908 1497 Rat rno-miR-192 miRNA epigallocatechin-3-gallate (EGCG) chronic renal injury cadmium (Cd) pretreated Wistar albino rats EGCG treatment "decreased miR-21 and miR-192, enhanced miR-29a/b/c in kidney samples" 27474435 1498 Rat rno-miR-192 miRNA "2,4,6-trinitrobenzene sulfonic acid (TNBS)" colitis male Wistar rats inflamed colon "2,4,6-trinitrobenzene sulfonic acid (TNBS)/ethanol treatment" downregulated in inflamed colon 28572713 1499 Rat rno-miR-192 miRNA exercise (Ex) diabetes mellitus (DM) Streptozotocin- induced diabetic rats exercise treatment upregulated 25789230 1500 Rat rno-miR-192 miRNA high glucose (HG) diabetic nephropathy (DN) Rat glomerular mesangial cells high glucose (HG) treatment upregulated 30827272 1501 Rat rno-miR-192 miRNA astragaloside IV (AS-IV) diabetic nephropathy (DN) high glucose treated rat mesangial cells (RMCs) astragaloside (AS-IV) treatment downregulated 31572545 1502 Rat rno-miR-192 miRNA captopril diabetic nephropathy (DN) diabetes rats kidney tissue captopril treatment downregulated 31433203 1503 Rat rno-miR-192 miRNA high glucose (HG) diabetic nephropathy (DN) rat mesangial cells (RMCs) high glucose (HG) treatment upregulated 31572545 1504 Rat rno-miR-192 miRNA spironolactone diabetic nephropathy (DN) diabetes rats kidney tissue spironolactone treatment downregulated 31433203 1505 Rat rno-miR-192 miRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissue streptozotocin (STZ) treatment upregulated 31433203 1506 Rat rno-miR-192 miRNA acetaminophen (APAP) drug-induced liver injury (DILI) serum acetaminophen (APAP) treatment dysregulated 22624025 1507 Rat rno-miR-192 miRNA dioscorea bulbifera (DB) drug-induced liver injury (DILI) serum dioscorea bulbifera (DB) treatment upregulated 22624025 1508 Rat rno-miR-192 miRNA hypoxia ischemia/reperfusion (I/R) injury H9C2 cells hypoxia induce upregulated 30280798 1509 Rat rno-miR-192 miRNA cisplatin (DDP) kidney damage male Wistar rats cisplatin treatment upregulated 24880025 1510 Rat rno-miR-192 miRNA silymarin (Sm) liver damage thioacetamide (TAA) treated rat Blood and liver tissues silymarin (Sm) treatment upregulated 31811641 1511 Rat rno-miR-192 miRNA thioacetamide (TAA) liver damage blood and liver tissues thioacetamide (TAA) treatment downregulated 31811641 1512 Rat rno-miR-192 miRNA radiation breast cancer rat mammary cancer tissues radiation treatment upregulated 23273170 1513 Rat rno-miR-192 miRNA paclitaxel (PTX) pancreatic cancer (PC) renal tissue of rats paclitaxel?treatment treatment downregulated 21984124 1514 Rat rno-miR-192 miRNA streptozocin (STZ) type 1 diabetes mellitus (T1DM) serum streptozotocin (STZ) treatment upregulated 30186503 1515 Rat rno-miR-192-5p miRNA isoproterenol acute cardiac injury urine tissues isoproterenol treatment upregulated 27605421 1516 Rat rno-miR-192-5p miRNA gentamicin acute kidney injury (AKI) urine gentamicin treatment upregulated 33263228 1517 Rat rno-miR-192-5p miRNA hypoxia/reoxygenation (H/R) cardiomyocyte apoptosis H9c2 cardiomyocytes hypoxia/reoxygenation (H/R) treatment upregulated 27780314 1518 Rat rno-miR-192-5p miRNA methane diabetic retinopathy (DR) Retinal?tissues methane treatment upregulated 26363454 1519 Rat rno-miR-192-5p miRNA angiotensin II (Ang II) hypertensive nephropathy (HN) rat renal artery endothelial cells (RRAECs) angiotensin II (Ang II) treatment upregulated 32346437 1520 Rat rno-miR-192-5p miRNA hypoxia/reoxygenation (H/R) hypoxia/reoxygenation (H/R) injury H9c2 cells hypoxia/reoxygenation (H/R) treatment upregulated 27780314 1521 Rat rno-miR-192-5p miRNA hypoxia hypoxic/ischemic injury Male Sprague Dawley rats "were exposed to hypoxia (9.5-10% O2) for 1, 5, or 10 days" upregulated 29262398 1522 Rat rno-miR-192-5p miRNA ischemia/reperfusion (I/R) kidney damage Sprague-Dawley rats urine ischemia/reperfusion (I/R) treatment upregulated 28056546 1523 Rat rno-miR-192-5p miRNA monocrotaline (MCT) liver sinusoidal endothelial cells (LSEC) injury serum monocrotaline treatment upregulated 30019166 1524 Rat rno-miR-192-5p miRNA lipopolysaccharide (LPS) myocardial injury H9c2 cells lipopolysaccharide (LPS) treatment downregulated of KCNQ1OT1 advances cardiac injury through regulating miR-192-5p/XIAP axis during sepsis. 32102564 1525 Rat rno-miR-192-5p miRNA high fat diet (HFD) nonalcoholic fatty liver disease (NAFLD) Sprague Dawley rats liver high fat diet (HFD) feed upregulated in liver 29290651 1526 Rat rno-miR-192-5p miRNA liraglutide nonalcoholic fatty liver disease (NAFLD) HDF rats liver injection of liraglutide downregulated in liver 29290651 1527 Rat rno-miR-192-5p miRNA 6-hydroxydopamine (6-OHDA) parkinson's disease (PD) rat pheochromocytoma PC12 cells 6-hydroxydopamine (6-OHDA) treatment upregulated 30552896 1528 Rat rno-miR-192-5p miRNA baicalin (BAI) parkinson's disease (PD) 6-hydroxydopamine (6-OHDA)-treated rat pheochromocytoma PC12 cells baicalin (BAI) treatment downregulated 30552896 1529 Rat rno-miR-192-5p miRNA baicalin (BAI) parkinson's disease (PD) PC-12 cells baicalin (BAI) treatment Baicalin alleviates 6-hydroxydopamine-induced neurotoxicity in PC12 cells by downregulated of microRNA-192-5p. 30552896 1530 Rat rno-miR-193 miRNA acetaminophen (APAP) drug-induced liver injury (DILI) serum acetaminophen (APAP) treatment dysregulated 22624025 1531 Rat rno-miR-193 miRNA dioscorea bulbifera (DB) drug-induced liver injury (DILI) serum dioscorea bulbifera (DB) treatment upregulated 22624025 1532 Rat rno-miR-193 miRNA pilocarpine epilepsy adult male rats brain tissue and heart tissue 50 days of pilocarpine treatment downregulated in the brain tissue 24530830 1533 Rat rno-miR-193 miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment downregulated 27041227 1534 Rat rno-miR-193 miRNA cisplatin (DDP) kidney damage male Wistar rats cisplatin treatment upregulated 24880025 1535 Rat rno-miR-193 miRNA cadmium (Cd) ovary structure and function Wistar rats cadmium (Cd) treatment upregulated 24462979 1536 Rat rno-miR-193 miRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) lung tissues monocrotaline treatment downregulated 28000863 1537 Rat rno-miR-193-3p miRNA high fat diet (HFD) aging-related non-alcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD) feed downregulated 31899128 1538 Rat rno-miR-193-3p miRNA apolipoprotein A-I mimetic peptide 4F pulmonary arterial hypertension (PAH) monocrotaline rat lung tissue and serum apolipoprotein A-I mimetic peptide 4F treatment miR193 downregulated 24963038 1539 Rat rno-miR-193a miRNA fish oil and pectin colorectal cancer (CRC) colon tissue of rats corn oil ¡À fish oil with pectin ¡À cellulose upregulated 21406606 1540 Rat rno-miR-193a miRNA fructose renal dysfunction rat glomeruli and cultured differentiated podocytes fructose treatment upregulated 31085161 1541 Rat rno-miR-193a miRNA Magnesium isoglycyrrhizinate (MgIG) renal dysfunction fructose-treated rat glomeruli and cultured differentiated podocytes Magnesium isoglycyrrhizinate (MgIG) treatment downregulated 31085161 1542 Rat rno-miR-193a-3p miRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues; NR8383 cells lipopolysaccharide (LPS) treatment rats in LPS group also resulted in a decrease in ZFAS1 expression and increase in miR-193a-3p expression in lung tissues 33848686 1543 Rat rno-miR-193a-3p miRNA amyloid-¦Â (A¦Â) 25-35 Alzheimer's disease (AD) PC12 cells amyloid-¦Â (A¦Â) 25-35 treatment downregulated 31857133 1544 Rat rno-miR-193a-3p miRNA amyloid-¦Â (A¦Â) 25-35 Alzheimer's disease (AD) PC-12 cells amyloid-¦Â (A¦Â) 25-35 treatment miR-193a-3p was significantly downregulated in PC-12 cells. 31857133 1545 Rat rno-miR-193a-3p miRNA ¦Ä-opioid receptor (DOR) hypoxic/ischemic injury hearts ¦Ä-opioid receptor (DOR) activation treatment upregulated 27576463 1546 Rat rno-miR-193a-3p miRNA FK506 osteogenesis rat bone marrow stromal cells (BMSCs) FK506 treatment upregulated 28560399 1547 Rat rno-miR-193a-5p miRNA caerulein (Cae) acute pancreatitis (AP) AR42J cells caerulein treatment "circHIPK3 promotes pyroptosis in acinar cells through regulation of the miR-193a-5p/GSDMD axis, which eventually aggravates AP disease." 32318575 1548 Rat rno-miR-193b-3p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) PC12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment MiR-193b-3p has a potentially neuroprotective effect on focal cerebral I/R-induced injury by inhibiting 5-LOX expression 32032565 1549 Rat rno-miR-19-3p miRNA sevoflurane (SEV) neuron proliferation primary cultured neonatal rats neurons ?sevoflurane (SEVO) treatment upregulated 30540563 1550 Rat rno-miR-194 miRNA caerulein (Cae) acute pancreatitis (AP) "AR42J, a rat pancreatic acinar cell line" caerulein (Cae) treatment downregulated 31518341 1551 Rat rno-miR-194 miRNA burn injury burn-induced hyperglycemia rats serum from burn rats treatment miR-194 expression was significantly elevated 25186839 1552 Rat rno-miR-194 miRNA serum burn-induced hyperglycemia Rat myoblast L6 cells serum from burn rats treatment miR-194 expression was significantly elevated 25186839 1553 Rat rno-miR-194 miRNA citrulline gastrointestinal toxicity rats citrulline treatment "Fecal miR-194 levels upregulated," 27189632 1554 Rat rno-miR-194 miRNA palmitate and palmitate plus oleate. insulin resistance (IR) mouse myoblasts palmitate and palmitate plus oleate treatment upregulated 21183973 1555 Rat rno-miR-194 miRNA lipopolysaccharide (LPS) intervertebral disc degeneration (IDD) NP cells lipopolysaccharide (LPS) treatment MiR-194 expression was reduced in LPS-induced NP cells. 29745371 1556 Rat rno-miR-194 miRNA silymarin (Sm) liver damage thioacetamide (TAA) treated rat Blood and liver tissues silymarin (Sm) treatment upregulated 31811641 1557 Rat rno-miR-194 miRNA thioacetamide (TAA) liver damage blood and liver tissues thioacetamide (TAA) treatment downregulated 31811641 1558 Rat rno-miR-194 miRNA radiation breast cancer rat mammary cancer tissues radiation treatment upregulated 23273170 1559 Rat rno-miR-194 miRNA lipopolysaccharide (LPS) myocardial injury H9c2 cells lipopolysaccharide (LPS) treatment The expression level of microRNA-194 was increased in LPS-induced H9c2 cardiomyocytes injury model in a time-dependent manner. 29687865 1560 Rat rno-miR-194 miRNA lycium barbarum polysaccharide (LBP) spinal cord injury (SCI) PC-12 cells Lycium barbarum polysaccharides (LBPs) treatment downregulated 30308510 1561 Rat rno-miR-194-1 miRNA hypoxia stroke middle cerebral artery occlusion (MCAO) Sprague-Dawley rat middle cerebral artery occlusion (MCAO) treatment downregulated 29113076 1562 Rat rno-miR-194-3p miRNA propofol (PPF) neurotoxicity primary cultured neural stem cells (NSCs) propofol treatment upregulated 29679758 1563 Rat rno-miR-194-5p miRNA methamphetamine (METH) addiction nucleus accumbens tissues Methamphetamine treatment dysregulated 28681200 1564 Rat rno-miR-194-5p miRNA hypothermia oxygen glucose deprivation stroke primary neuron tisssues hypothermia oxygen glucose deprivation treatment miR-194-5p expression was significantly downregulated in hypothermia oxygen glucose deprivation-treated neurons in vitro. 30232383 1565 Rat rno-miR-195 miRNA hypoxia/reoxygenation (H/R) cardiomyocyte apoptosis H9c2 cells hypoxia/reoxygenation (H/R) injury treatment upregulated 27608900 1566 Rat rno-miR-195 miRNA isoprenaline cardiac hypertrophy neonatal rat ventricular myocytes isoprenaline treatment upregulated 25100012 1567 Rat rno-miR-195 miRNA thyroglobulin (Tg) cell proliferation rat FRTL-5 thyroid cells Tg treatment upregulated 24479877 1568 Rat rno-miR-195 miRNA hypoxia cerebral ischemia injury (CII) brain tissues middle cerebral artery occlusion (MCAO) treatment downregulated in rat brain samples 28849133 1569 Rat rno-miR-195 miRNA chronic brain hypoperfusion (CBH) dementia neurons? cells chronic brain hypoperfusion (CBH) treatment downregulated 23447608 1570 Rat rno-miR-195 miRNA high-fat high-fructose diet (HFHFD) diabetic cardiomyopathy (DCM) heart tissues high-fat high-fructose diet (HFHFD) feed upregulated 30320520 1571 Rat rno-miR-195 miRNA high-intensity interval training (HIIT) diabetic cardiomyopathy (DCM) diabetic rats heart tissues high-intensity interval training (HIIT) treatment downregulated 30320520 1572 Rat rno-miR-195 miRNA high-intensity interval training (HIIT) diabetic cardiomyopathy (DCM) heart sissues high-intensity interval training (HIIT) HIIT effectively decreases the expression of miR-195 and increases the expression of Sirt1 and BCL-2 in diabetic rats compared with continuous endurance training (CET). 30320520 1573 Rat rno-miR-195 miRNA astragalus polysaccharide (APS) diabetic retinopathy (DR) high glucose (HG)-treated rat primary retinal pigment epithelium (RPE) cells astragalus polysaccharide (APS) treatment downregulated 31117931 1574 Rat rno-miR-195 miRNA high glucose (HG) diabetic retinopathy (DR) rat primary retinal pigment epithelium (RPE) cells high glucose (HG) treatment upregulated 31117931 1575 Rat rno-miR-195 miRNA L5 spinal nerve ligation (SNL) duchenne muscular dystrophy (DMD) spinal nerve ligation and spinal microglia L5 spinal nerve ligation (SNL) treatment that miR-195 levels were markedly increased in rats subjected to L5 spinal nerve ligation (SNL);Upregulated miR-195 was also found in spinal microglia of rats with SNL 23361941 1576 Rat rno-miR-195 miRNA hypoxia glycolysis cardiomyocytes hypoxia treatment "Meanwhile, miR-27 and miR-195 were also upregulated in hypoxia-induced cardiomyocytes." 33819184 1577 Rat rno-miR-195 miRNA oxymatrine hepatic stellate cell (HSC) activation TGF-¦Â1-treated HSC-T6 cells Oxymatrine (OM) treatment downregulated 31221141 1578 Rat rno-miR-195 miRNA TGF-¦Â1 hepatic stellate cell (HSC) activation HSC-T6 cells TGF-¦Â1 treatment upregulated 31221141 1579 Rat rno-miR-195 miRNA diethylnitrosamine (DEN) liver fibrosis rats diethyl nitrosamine (DEN) treatment upregulated 28929107 1580 Rat rno-miR-195 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 1581 Rat rno-miR-195-5p miRNA hypoxia acute kidney injury (AKI) NRK-52E cells hypoxia treatment miR-195-5p was found to be markedly reduced under hypoxic conditions. 32492657 1582 Rat rno-miR-195-5p miRNA particulate matter (PM2.5) allergic rhinitis (AR) nasal mucosa particulate matter 2.5 (PM2.5) treatment upregulated 32192351 1583 Rat rno-miR-195-5p miRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cardiomyocytes angiotensin II (Ang II) treatment upregulated 31341888 1584 Rat rno-miR-195-5p miRNA high glucose (HG) diabetic cardiomyopathy (DCM) rat cardiomyocytes high glucose (HG) treatment upregulated 31729781 1585 Rat rno-miR-195-5p miRNA high glucose (HG) diabetic cardiomyopathy (DCM) Neonatal rat ventricular myocyte high glucose treatment upregulated 31729781 1586 Rat rno-miR-195-5p miRNA lipopolysaccharide (LPS) lung injury lung tissues Lipopolysaccharide (LPS) treatment CASC9 was markedly downregulated while miR-195-5p was significantly upregulated in HSAECs treated by LPS and lung tissues of rats with sepsis. 32221619 1587 Rat rno-miR-195-5p miRNA hypoxia cell proliferation and migration apoptosis-resistant pulmonary microvascular endothelial cells (PVECs/AR) hypoxia treatment upregulated 28862358 1588 Rat rno-miR-195-5p miRNA hypoxia pulmonary arterial hypertension (PAH) rats pulmonary microvascular endothelial cells (PVECs/AR) exposure to hypoxia for 12 or 24 h upregulated 28862358 1589 Rat rno-miR-1956-5p miRNA iohexol contrast-induced acute kidney injury (CIAKI) Renal tissue "Animals were dehydrated for 48 h and then underwent furosemide (10 mL/kg; Harvest Pharmaceutical, Shanghai, China) injection 30 min before administration of iohexol (15 mL/kg, group CI-AKI; iodine, 350 mg/mL; GE Healthcare, Shanghai, China) or 0.9% normal saline (15 mL/kg, control group)." miR-1956-5p was significantly upregulated in Contrast-induced acute kidney injury (CI-AKI). 31234008 1590 Rat rno-miR-196-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 1591 Rat rno-miR-196a miRNA amyloid-¦Â (A¦Â) 25-35 Alzheimer's disease (AD) hippocampus tissues amyloid-¦Â (A¦Â) 25-35 treatment downregulated 31119777 1592 Rat rno-miR-196a miRNA "3,5-diiodo-L-thyronine (T2)" browning of white adipocytes subcutaneous white adipose tissue (sWAT) receiving a high fat diet for 10 weeks and being subsequently treated for four weeks with an HFD together with the administration of T? upregulated 30889829 1593 Rat rno-miR-196a miRNA high fat diet (HFD) browning of white adipocytes subcutaneous white adipose tissue (sWAT) high fat diet (HFD) feed downregulated 30889829 1594 Rat rno-miR-196a miRNA ¦Ä-opioid receptor (DOR) hypoxic/ischemic injury hearts ¦Ä-opioid receptor (DOR) activation treatment upregulated 27576463 1595 Rat rno-miR-196a miRNA oxygen glucose deprivation (OGD) ischemic brain injury cultured neonatal rat cortical neurons oxygen-glucose deprivation (OGD) induce treatment upregulated 30720182 1596 Rat rno-miR-196a-5p miRNA chronic constriction injury (CCI) neuropathic pain (NP) Schwann cells chronic constriction injury (CCI) induce Silencing H19 inhibited NP by suppressing CDK5/p35 and p-CREB phosphorylation via the miR-196a-5p/CDK5 axis. 32903807 1597 Rat rno-miR-196a-5p miRNA steroids osteonecrosis bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 26459755 1598 Rat rno-miR-196b miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment upregulated 21094214 1599 Rat rno-miR-196b-5p miRNA pilocarpine mesial temporal lobe epilepsy (MTLE) hippocampi pilocarpine treatment upregulated 27695061 1600 Rat rno-miR-196b-5p miRNA hypoxia stroke middle cerebral artery occlusion (MCAO) Sprague-Dawley rat middle cerebral artery occlusion (MCAO) treatment upregulated 29113076 1601 Rat rno-miR-199a miRNA 1-methyl-4-phenylpyridinium (MPP+) autophagy PC-12 cells 1-methyl-4-phenylpyridinium (MPP+) treatment MPP+ decreased miR-199a expression in PC12 cells in a concentration-dependent manner. 32151238 1602 Rat rno-miR-199a miRNA isoproterenol cardiac fibrosis cardiac fibroblasts (CFs) isoproterenol (ISO) treatment upregulated 31115026 1603 Rat rno-miR-199a miRNA estradiol-17¦Â (E2) embryo implantation rat uterine horns estradiol-17¦Â (E2) treatment downregulated 24149516 1604 Rat rno-miR-199a miRNA Safflor yellow B (SYB) hypoxia-induced injury rats RAECs SYB (0.8 mM) treatment upregulated 29212172 1605 Rat rno-miR-199a miRNA hypoxia hypoxia-induced injury H9c2 cells hypoxia induce upregulated 31307244 1606 Rat rno-miR-199a miRNA quercetin hypoxia-induced injury hypoxia-induced H9c2 cells Quercetin treatment downregulated 31307244 1607 Rat rno-miR-199a miRNA 3-nitropropionic acid liver cirrhosis brain tissue of rats 3-nitropropionic acid treatment downregulated 22079324 1608 Rat rno-miR-199a miRNA nicotine nicotine intake female rats prefrontal cortex (PFC) tissues nicotine exposure upregulated 30504847 1609 Rat rno-miR-199a miRNA dexamethasone (DEX) osteogenesis bone marrow mesenchymal stem cells (BMSCs) dexamethasone (DEX) treatment "miR-199a was upregulated during OD of BMSCs, while DEX treatment caused a significant reduction in miR-199a." 32869899 1610 Rat rno-miR-199a miRNA dexamethasone (DEX) oxidative stress PC-12 cells dexamethasone (DEX) treatment Dex attenuated H 2O2-induced oxidative damage in PC12 cells by down-regulating miR-199a expression. 32024386 1611 Rat rno-miR-199a miRNA estradiol-17¦Â (E2) pseudopregnant rat uterine horns estradiol-17¦Â (E2) treatment Treatmentwith17b-estradiol or both 17b-estradiol and progesterone significantly diminished miR199a levels 24149516 1612 Rat rno-miR-199a miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment upregulated 21094214 1613 Rat rno-miR-199a miRNA isoproterenol ¦Â-adrenoceptor intervention rat heart tissues isoproterenol (ISO) treatment upregulated 22847192 1614 Rat rno-miR-199a-3p miRNA particulate matter (PM2.5) allergic rhinitis (AR) nasal mucosa particulate matter 2.5 (PM2.5) treatment upregulated 32192351 1615 Rat rno-miR-199a-3p miRNA palmitate diabetes mellitus (DM) INS-1 cells palmitate (Pal) treatment upregulated 30131392 1616 Rat rno-miR-199a-3p miRNA hepatitis B virus (HBV) and TGF-¦Â1 hepatic progenitor cells (HPCs) transformation Hepatic stem-like epithelial cells (LE/6) HBx and TGF-¦Â1 exposure upregulated 31740785 1617 Rat rno-miR-199a-3p miRNA hypoxia neuronal cell injury C6 glioma cells hypoxia treatment upregulated 33110474 1618 Rat rno-miR-199a-3p miRNA 1-methyl-4-phenylpyridinium (MPP+) parkinson's disease (PD) PC-12 cells 1-methyl-4-phenylpyridinium (MPP+) treatment downregulated 33494069 1619 Rat rno-miR-199a-3p miRNA mono-n-butyl phthalate (MBP) precocious puberty and testicular tumors testicular Sertoli cells (SCs) mono-n-butyl phthalate (MBP) treatment upregulated 29162477 1620 Rat rno-miR-199a-3p miRNA glucocorticoid (GC) respiratory distress syndrome lung Glucocorticoids treatment downregulated 26997989 1621 Rat rno-miR-199a-3p miRNA streptozocin (STZ) diabetic retinopathy (DR) ?retinas?tissues streptozotocin (STZ) treatment downregulated 22156553 1622 Rat rno-miR-199a-5p miRNA insert a cannula connected with a saline container into the anterior chamber acute ocular hypertension (AOH) adult albino rats retinal ganglion cells (RGCs) and microglial cells insert a cannula connected with a saline container into the anterior chamber upregulated 27535721 1623 Rat rno-miR-199a-5p miRNA high glucose (HG) apoptosis INS-1 rat pancreatic ¦Â-cells high glucose (HG) treatment upregulated 28338182 1624 Rat rno-miR-199a-5p miRNA lithium chloride and pilocarpine epilepsy Hippocampal lithium-pilocarpine treatment upregulated 26945677 1625 Rat rno-miR-199a-5p miRNA angiotensin II (Ang II) heart failure (HF) H9c2 cells angiotensin II (Ang II) treatment upregulated 29703907 1626 Rat rno-miR-199a-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment upregulated 31059047 1627 Rat rno-miR-199a-5p miRNA lidocaine neurotoxicity spinal cord of rats Lidocaine treatment Increased expression of miR-199a-5p in the spinal cord of rats treated with 10 % lidocaine was assessed by qRT-PCR. 33166664 1628 Rat rno-miR-199a-5p miRNA activated protein C(APC) sepsis rats blood and liver tissue activated protein C treatment aPC treatment coordinates beneficial cytoprotective effects during sepsis by modulating miRNA expression 22940033 1629 Rat rno-miR-199a-5p miRNA lidocaine spinal cord neurotoxicity spinal cord white matter lidocaine treatment upregulated 33166664 1630 Rat rno-miR-199b-5p miRNA lipopolysaccharide (LPS) rejection after lung transplantation allograft tissues lipopolysaccharide (LPS) treatment downregulated 29779167 1631 Rat rno-miR-19a miRNA hypoxia/reoxygenation (H/R) hypoxia/reoxygenation (H/R) injury H9C2 cells hypoxia-reoxygeneration (H/R) treatment downregulated 29054970 1632 Rat rno-miR-19a miRNA ethanol (EtOH) acute gastric mucosal injury gastric tissues?of rat oral administration of ethanol downregulated 23830200 1633 Rat rno-miR-19a miRNA hypoxia acute myocardial infarction (AMI) heart tissues and primary cardiomyocytes in vitro hypoxia induce downregulated 31633225 1634 Rat rno-miR-19a miRNA propofol (PPF) cerebral injury PC12 cells Propofol treatment "propofol relieved Glu-triggered apoptosis and autophagy of PC12, and activated AMPK and mTOR pathways by suppressing miR-19a expression" 31913544 1635 Rat rno-miR-19a miRNA hypoxia coronary microvascular obstruction injury cardiac myocytes hypoxia treatment miR-19a was gradually reduced as time increased in primary cardiomyocytes after hypoxia stimulation. 31633225 1636 Rat rno-miR-19a miRNA dexamethasone (DEX) hormonal regulation adrenals?tissues dexamethasone (DEX) treatment downregulated 24205079 1637 Rat rno-miR-19a miRNA hypoxia hypoxia-induced injury primary cardiomyocytes hypoxia treatment miR-19a was gradually reduced as time increased in primary cardiomyocytes after hypoxia stimulation. 31633225 1638 Rat rno-miR-19a miRNA hypoxia ischemic stroke (IS) rat brain tissues middle cerebral artery occlusion/reperfusion (MCAO/R) injury downregulated 31170091 1639 Rat rno-miR-19a miRNA oxygen glucose deprivation (OGD) ischemic stroke (IS) rat neuronal cells oxygen glucose deprivation (OGD) treatment downregulated 31170091 1640 Rat rno-miR-19a miRNA hypoxia microvascular obstruction (MO) cardiomyocytes hypoxia treatment downregulated 27220268 1641 Rat rno-miR-19a-3p miRNA phenylephrine (PE) cardiac hypertrophy primary cardiomyocytes; myocardium phenylephrine (PE) treatment downregulated 32096186 1642 Rat rno-miR-19a-3p miRNA isoproterenol drug-induced cardiac injury (DICI) heart tissues isoproterenol treatment upregulated 29355689 1643 Rat rno-miR-19a-3p miRNA Shenfu Injection (SFI) cardiac hypertrophy abdominal aortic constriction-induced myocardial hypertrophic rats cardiomyocytes Shenfu Injection (SFI) treatment upregulated 29549288 1644 Rat rno-miR-19a-3p miRNA oxygen glucose deprivation (OGD) ischemic stroke (IS) Primary neurons oxygen-glucose deprivation (OGD) treatment upregulated 31168302 1645 Rat rno-miR-19b miRNA glucagon-like peptide-1 (GLP-1) cholesterol-induced lipotoxicity liver tissues Glucagon-like peptide-1 (GLP-1) treatment downregulated 30308521 1646 Rat rno-miR-19b miRNA TGF-¦Â1 liver fibrosis Primary hepatocytes and hepatic stellate cells (HSCs) transforming growth factor beta 1 (TGF-¦Â1) treatment downregulated 29281894 1647 Rat rno-miR-19b miRNA hypoxia hypoxia-induced injury PC12 cells hypoxia induce downregulated 30767206 1648 Rat rno-miR-19b miRNA alcohol liver damage hepatic stellate cell (HSC) alcohol exposure downregulated 27291156 1649 Rat rno-miR-19b miRNA H2O2 myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells H2O2 treatment downregulated 26918829 1650 Rat rno-miR-19b miRNA irisin "myocardial remodeling,apoptosis" embryonic rat cardiac myoblast H9c2 cell line irisin treatment upregulated 31966617 1651 Rat rno-miR-19b miRNA angiotensin II (Ang II) expression regulation Cardiomyocytes isolated from 1- to 3-day-old neonatal rats angiotensin II (Ang II) treatment downregulated 24296617 1652 Rat rno-miR-19b miRNA angiotensin II (Ang II) expression regulation Cardiomyocytes from neonatal rats angiotensin II (Ang II) treatment downregulated 23951138 1653 Rat rno-miR-19b miRNA perfluorooctane sulfonic acid (PFOS) perfluorooctane sulfonate (PFOS)-induced toxic action rat liver tissue dams received 3.2 mg/kg PFOS in their feed from gestational day 1 (GD1) to postnatal day 7 (PND 15) treatment different expression 24420840 1654 Rat rno-miR-19b miRNA perfluorooctane sulfonic acid (PFOS) perfluorooctane sulfonate (PFOS)-induced toxic action rat liver tissue dams received 3.2 mg/kg PFOS in their feed from gestational day 1 (GD1) to postnatal day 7 (PND 7) treatment different expression 24420840 1655 Rat rno-miR-19b-1 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 1656 Rat rno-miR-19b-3p miRNA cyclic mechanical stretch (CMS) hypertension-induced vascular remodeling vascular smooth muscle cells (VSMCs) were harvested from rat thoracic aorta 15% cyclic stretch induce downregulated 30690026 1657 Rat rno-miR-19b-3p miRNA rosmarinic acid (RA) irradiation-induced pulmonary fibrosis lung regions rosmarinic acid (RA) treatment "RA attenuated RhoA/Rock signaling through upregulating miR-19b-3p, leading to the inhibition of fibrosis." 33149731 1658 Rat rno-miR-1a miRNA quinone compounds P3H4 renal cell carcinoma (RCC) renal cancer tissue P3H4 treatment miR-1a was significantly upregulated in rat renal cancer tissue after the treatment of P3H4 30178839 1659 Rat rno-miR-1a-3p miRNA H2O2 ischemia/reperfusion (I/R) injury neonatal rat ventricular cells (NRVCs) H2O2 treatment upregulated 30292140 1660 Rat rno-miR-1a-3p miRNA metformin (Met) ischemia/reperfusion (I/R) injury H2O2-treated neonatal rat ventricular cells (NRVCs) Metformin treatment downregulated 30292140 1661 Rat rno-miR-1b miRNA methamphetamine (METH) methamphetamine (METH) addiction brain tissues Methamphetamine (METH) treatment downregulated 32893733 1662 Rat rno-miR-1b-5p miRNA anisakis complete extract (CE) anisakiasis sera anisakis complete extract (CE) treatment "mmu-miR-1b-5p and mmu-miR-10b-5p (a cancer-related miRNA) were significantly decreased (P?10-fold. In contrast, the expression levels of miR-192, 194, 215 and 375 were dramatically reduced (?0.32-fold) in adenocarcinomas." 19825969 2363 Rat rno-miR-223 miRNA heat stress febrile seizure (FS) hippocampus tissues hot water-bath induce downregulated 30947016 2364 Rat rno-mir-223 miRNA phenylephrine (PE) hypertrophy neonatal rat cardiomyocytes (HNRCs) phenylephrine (PE) treatment downregulated 29110214 2365 Rat rno-miR-223 miRNA lipopolysaccharide (LPS) inflammation Isolated rat nucleus pulposus (NP) cells lipopolysaccharide (LPS) treatment downregulated 29707878 2366 Rat rno-miR-223 miRNA ischemic brain extract (IBE) ischemic injury "C6 rat astrocytoma cells, and primary rat MSCc (rMSCs)" IBE treatment upregulated 24999035 2367 Rat rno-miR-223 miRNA electroacupuncture (EA) ischemic stroke (IS) subventricular zone (SVZ) and hippocampus tissues electroacupuncture (EA) treatment upregulated 31883264 2368 Rat rno-miR-223 miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) primary cortical neuron culture oxygen-glucose deprivation and reoxygenation (OGD/R) treatment FGD5-AS1 may protect the neuron against OGD/R injury via acting as a ceRNA for miR-223 to mediate IGF1R expression 32337949 2369 Rat rno-miR-223 miRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia treatment upregulated 29608885 2370 Rat rno-miR-223 miRNA TGF-¦Â1 myocardial infarction (MI) Cultured cardiac fibroblasts (CFs) TGF-¦Â1 treatment upregulated 29689569 2371 Rat rno-miR-223 miRNA emodin myocarditis LPS-treated H9c2 cells Emodin treatment downregulated 30745529 2372 Rat rno-miR-223 miRNA lipopolysaccharide (LPS) myocarditis H9c2 cells lipopolysaccharide (LPS) treatment upregulated 30745529 2373 Rat rno-miR-223 miRNA 2-methoxyestradiol (2-Me) obstructive sleep apnea (OSA) pulmonary artery smooth muscle cells (PASMCs); lung tissues 2-methoxyestradiol (2-Me) treatment "Chronic intermittent hypoxia (CIH) decreased the expression of miR-223, whereas 2-Me reversed the downregulated of miR-223 both in vivo and in vitro." 30246291 2374 Rat rno-miR-223 miRNA 2-methoxyestradiol (2-Me) pulmonary hypertension (PH) Chronic intermittent hypoxia (CIH) model rat lung tissues 2-methoxyestradiol (2-Me) treatment upregulated 30246291 2375 Rat rno-miR-223 miRNA hypoxia pulmonary hypertension (PH) lung tissues Chronic intermittent hypoxia (CIH) induce downregulated 30246291 2376 Rat rno-miR-223 miRNA X-rays radiation-induced skin injury rats irradiated skin 45-Gy electron beam treatment upregulated 24447893 2377 Rat rno-miR-223 miRNA lipopolysaccharide (LPS) septic shock Wistar rats serum LPS (10 mg/kg) treatment upregulated 24915805 2378 Rat rno-miR-223 miRNA angelica polysaccharide (AP) spinal cord injury (SCI) PC-12 cells angelica polysaccharide (AP) treatment AP pre-treatment attenuated LPS-induced miR-223 expression level increase in PC-12 cells. 30372834 2379 Rat rno-miR-223 miRNA electroacupuncture (EA) stroke cortex tissues Electroacupuncture (EA) treatment upregulated 31237865 2380 Rat rno-miR-223 miRNA dextran sodium sulfate (DSS) ulcerative colitis (UC) colon tissues dextran sulfate sodium (DSS) treatment upregulated 31210320 2381 Rat rno-miR-223 miRNA methylglyoxal (MGO) vascular tones A10 cells methylglyoxal (MGO) treatment miR-223 expression in the cultured SMCs after 300 ¦ÌM MGO exposure by 5-6 folds. 32151743 2382 Rat rno-miR-223 miRNA naringenin spinal cord injury (SCI) spinal cords Naringenin (NR)treatment downregulated 27432064 2383 Rat rno-miR-223-3p miRNA high fat diet (HFD) aging-related non-alcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD) feed upregulated 31899128 2384 Rat rno-miR-223-3p miRNA angiotensin II (Ang II) hypertensive nephropathy (HN) rat renal artery endothelial cells (RRAECs) angiotensin II (Ang II) treatment upregulated 32346437 2385 Rat rno-miR-223-3p miRNA hypoxia ischemic heart disease (IHD) H9c2 cells hypoxia induce upregulated 30336138 2386 Rat rno-miR-223-3p miRNA sevoflurane (SEV) learning and memory deficits rat neuron cells sevoflurane (SEVO) treatment upregulated 31450504 2387 Rat rno-miR-223-3p miRNA hypoxia pulmonary arterial hypertension (PAH) pulmonary arterial smooth muscle cells (PASMCs) hypoxia induce downregulated 30507047 2388 Rat rno-miR-223-3p miRNA hypoxia pulmonary arterial hypertension (PAH) primary rat pulmonary arterial smooth muscle cells (PASMCs) hypoxia induce downregulated 30507047 2389 Rat rno-miR-223-3p miRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) pulmonary artery;right ventricle monocrotaline (MCT) treatment downregulated 30507047 2390 Rat rno-miR-223-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 2391 Rat rno-miR-223-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 2392 Rat rno-miR-22-3p miRNA insert a cannula connected with a saline container into the anterior chamber acute ocular hypertension (AOH) adult albino rats retinal ganglion cells (RGCs) and microglial cells insert a cannula connected with a saline container into the anterior chamber upregulated 27535721 2393 Rat rno-miR-22-3p miRNA gastrodin (GAS) cerebral ischemia/reperfusion (I/R) injury OGD/R-treated rat primary cortical neurons gastrodin (GAS) treatment upregulated 33839999 2394 Rat rno-miR-22-3p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia/reperfusion (I/R) injury Rat primary cortical neurons oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 33839999 2395 Rat rno-miR-22-3p miRNA berberine (BBR) hepatocellular carcinoma (HCC) HepG2 cells berberine (BBR) treatment upregulated 27904693 2396 Rat rno-miR-22-3p miRNA doxorubicin (DOX) ischemia/reperfusion (I/R) injury rats cardiomyocytes doxorubicin treatment downregulated 27919821 2397 Rat rno-miR-22-3p miRNA resveratrol pulmonary embolism pulmonary embolism (PE) induced heart tissues resveratrol (Res) treatment upregulated 31573048 2398 Rat rno-miR-22-3p miRNA angiotensin II (Ang II) thoracic aortic aneurysm (TAA) thoracic aorta angiotensin II (Ang II) treatment The expression of miR-22-3p in Ang II group was significantly lower than that in the normal group. 32633388 2399 Rat rno-miR-224 miRNA azoxymethane (AOM) colorectal cancer (CRC) rat colon Epithelial cells azoxymethane (AOM) treatment "Of the 27 miRNAs expressed at higher (P < 0.05) levels in tumors, miR-34a, 132, 223 and 224 were overexpressed at >10-fold. In contrast, the expression levels of miR-192, 194, 215 and 375 were dramatically reduced (?0.32-fold) in adenocarcinomas." 19825969 2400 Rat rno-miR-224 miRNA furan hepatotoxicity liver Furan treatment upregulated 27371368 2401 Rat rno-miR-224 miRNA lead acetate (PbAc) lead (Pb) acetate-induced thyrotoxicity thyroid tissues lead (Pb) exposure upregulated 29665650 2402 Rat rno-miR-224 miRNA selenium nanoparticles (SeNPs) lead (Pb) acetate-induced thyrotoxicity lead (Pb) acetate-exposured rats thyroid tissues Selenium nanoparticles (Se-NPs) treatment downregulated 29665650 2403 Rat rno-miR-224-5p miRNA cadmium (Cd) cadmium (Cd)-induced kidney injury renal cortex cadmium (Cd) treatment upregulated 29543730 2404 Rat rno-miR-224-5p miRNA "2,2',4,4'-tetrabromodiphenyl ether (BDE47)" hypothyroidism liver tissues and H4-II-E cells "2,2',4,4'-tetrabromodiphenyl ether (BDE47) treatment" downregulated 31901531 2405 Rat rno-miR-224-5p miRNA "2,2',4,4'-tetrabromodiphenyl ether (BDE47)" hypothyroidism H4-II-E cells "2,2',4,4'-tetrabromodiphenyl ether (BDE47) treatment" rno-miR-224-5p level was decreased by BDE47 in a dose-dependent manner. 31901531 2406 Rat rno-miR-224-5p miRNA glucocorticoid (GC) osteonecrosis of femoral head (ONFH) rat bone marrow stromal stem cells (BMSCs) glucocorticoids (GCs) treatment "In the present study, we demonstrated that miR-224-5p was upregulated in GC-treated BMSCs" 33453444 2407 Rat rno-miR-224-5p miRNA herb-partitioned moxibustion ulcerative colitis (UC) UC rats colon tissues herb-partitioned moxibustion upregulated 28246536 2408 Rat rno-miR-22-5p miRNA pirarubicin (THP) cardiomyocytes injury rat cardiomyocytes pirarubicin (THP) treatment "In this study, we developed an microRNA (miRNA) chip by replicating the rat model of THP-induced myocardial injury and identified miR-22-5p and the RAP1-member of RAS oncogene family/extracellular regulated protein kinases (RAP1/ERK) signaling pathway as an object of study" 32864822 2409 Rat rno-miR-22-5p miRNA rutin (RUT) cardiomyocytes injury rat cardiomyocytes rutin (RUT) treatment "In this study, we developed an microRNA (miRNA) chip by replicating the rat model of THP-induced myocardial injury and identified miR-22-5p and the RAP1-member of RAS oncogene family/extracellular regulated protein kinases (RAP1/ERK) signaling pathway as an object of study" 32864822 2410 Rat rno-miR-22-5p miRNA rutin (RUT) pirarubicin (THP)-induced myocardial damage myocardial tissues rutin (RUT) treatment "RUT significantly improved THP-induced myocardial damage , increased the expression of miR-22-5p" 32864822 2411 Rat rno-miR-22a-3p miRNA "3,5-diiodo-L-thyronine (T2)" glucose homeostasis serum from high fat diet fed rats "3,5-diiodo-L-thyronine (T2) treatment" downregulated 31719576 2412 Rat rno-miR-23 miRNA isoflurane oxidative stress H9c2 cells Isoflurane treatment downregulated 29627934 2413 Rat rno-miR-23a miRNA lipopolysaccharide (LPS) sepsis myocardial and kidney tissues lipopolysaccharide (LPS) treatment downregulated 33538509 2414 Rat rno-miR-23a miRNA streptozocin (STZ) acute diabete rats gastrocnemius streptozotocin treatment downregulated 24336651 2415 Rat rno-miR-23a miRNA H2O2 acute myocardial infarction (AMI) H9c2 cells H2O2 treatment upregulated 29488607 2416 Rat rno-miR-23a miRNA bone marrow mesenchymal stem cells (BMSCs) apoptosis infarcted rats myocardium bone marrow mesenchymal stem cells (BMSCs) treatment downregulated 28662151 2417 Rat rno-miR-23a miRNA hypoxia- and serum deprivation apoptosis bone marrow mesenchymal stem cell- (MSC) Hypoxia- and Serum Deprivation treatment downregulated 21698002 2418 Rat rno-miR-23a miRNA tumor necrosis factor alpha (TNF-¦Á) apoptosis mesenchymal stem cells tumor necrosis factor alpha (TNF-¦Á) treatment upregulated 24269648 2419 Rat rno-miR-23a miRNA ovalbumin (OVA) asthma lung tissues OVA treatment upregulated 31020662 2420 Rat rno-miR-23a miRNA isoproterenol and aldosterone cardiac hypertrophy Neonatal rat cardiomyocytes isoproterenol and aldosterone treatment upregulated 19574461 2421 Rat rno-miR-23a miRNA doxorubicin (DOX) cardiotoxicity primary neonatal rat ventricular myocytes (NRVMs) Doxorubicin (DOX) treatment upregulated 30831132 2422 Rat rno-miR-23a miRNA deep hypothermic circulatory arrest cerebral injury rat hippocampal tissues deep hypothermic circulatory arrest treatment downregulated 30824348 2423 Rat rno-miR-23a miRNA ginsenoside Rg1 diabetic foot ulcer (DFU) diabetic rats?incision area and tissue Ginsenoside Rg1 treatment downregulated 31158376 2424 Rat rno-miR-23a miRNA stimulation electrode epilepsy Adult male Sprague Dawley rats blood A bipolar stimulation electrode (distance between tips 500 ?m) was implanted in the angular bundle treatment dysregulated 24184920 2425 Rat rno-miR-23a miRNA formaldehyde formaldehyde inducted immune/inflammation rats were exposed to formaldehyde treatment downregulated 24304932 2426 Rat rno-miR-23a miRNA carbon tetrachloride (CCl4) liver fibrosis Liver tissues carbon tetrachloride (CCl4) treatment miR-23a expression increased significantly in hepatic fibrosis tissues. 30735452 2427 Rat rno-miR-23a miRNA berberine (BBR) inflammation LPS-treated adjuvant-induced arthritic synovial macrophages (AA-SM) berberine (BBR) treatment upregulated 30240693 2428 Rat rno-miR-23a miRNA NQDI1 (apoptosis signal-regulating kinase 1 (ASK1) inhibitor) inflammation LPS-treated adjuvant-induced arthritic synovial macrophages (AA-SM) NQDI1 treatment upregulated 30240693 2429 Rat rno-miR-23a miRNA TNF-¦Á and lipopolysaccharide (LPS) inflammation adjuvant-induced arthritic synovial macrophages (AA-SM) TNF-¦Á and lipopolysaccharide (LPS) treatment downregulated 30240693 2430 Rat rno-miR-23a miRNA H2O2 ischemia/reperfusion (I/R) injury H9c2 rat myocardial cell H2O2 downregulated 29272015 2431 Rat rno-miR-23a miRNA hypoxia neuron apoptosis SH-SY5Y cells 1% O2 hypoxia upregulated 28529459 2432 Rat rno-miR-23a miRNA hypoxia neuron apoptosis brain tissues chronic hypobaric hypoxia rat model as well as a tissue culture model where were exposed to upregulated 28529459 2433 Rat rno-miR-23a miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 2434 Rat rno-miR-23a-3p miRNA acupuncture intracerebral haemorrhage (ICH) brain tissues acupuncture?treatment Acupuncture also alleviated ferroptosis and decreased miR-23a-3p expression 33403590 2435 Rat rno-miR-23a-3p miRNA long-term potentiation(LTP) long-term potentiation (LTP) persistence Sprague-Dawley rats Dentate Gyrus Neuropil unilaterally at perforant path-dentate gyrus synapses upregulated in Dentate Gyrus Neuropil 28125614 2436 Rat rno-miR-23a-3p miRNA high glucose (HG) maternal hyperglycemia H9c2 cells high glucose (HG) treatment Upregulation of miRNA-23a-3p rescues high glucose-induced cell apoptosis and proliferation inhibition in cardiomyocytes 33197036 2437 Rat rno-miR-23a-3p miRNA ionizing radiation (IR) radiation-induced central nervous system toxicity Primary cortical neurons ionizing radiation (IR) treatment miR-23a-3p is rapidly decreased after neuronal irradiation. 32456284 2438 Rat rno-miR-23a-5p miRNA platelet-derived growth factor (PDGF) liver fibrosis hepatic stellate cells (HSCs) platelet-derived growth factor (PDGF) treatment upregulated 32306379 2439 Rat rno-miR-23b miRNA lipopolysaccharide (LPS) cardiomyopathy induced by sepsis H9C2 cardiomyoblasts lipopolysaccharide (LPS) treatment upregulated 30734878 2440 Rat rno-miR-23b miRNA hypoxia congenital heart disease (CHD) H9C2 cells prolonged hypoxia upregulated 29078258 2441 Rat rno-miR-23b miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 2442 Rat rno-miR-23b miRNA lipopolysaccharide (LPS) sepsis vascular endothelial cells (VECs) lipopolysaccharide (LPS) treatment Endothelial microvesicles (EMVs) play an important role in pulmonary vascular leakage and lung injury during sepsis by transferring functional miR-23b. 32766250 2443 Rat rno-miR-23b-3p miRNA streptozocin (STZ) diabetes mellitus (DM) hippocampus tissues streptozocin (STZ) treatment miRNA-23b-3p expression was upregulated in cognitive impairment of diabetic rats 30282005 2444 Rat rno-miR-23b-3p miRNA hypoxia/reoxygenation (H/R) ischemia/reperfusion (I/R)-mediated acute myocardial infarction (AMI) H9c2 cells hypoxia/reoxygenation (H/R) treatment upregulated 32558131 2445 Rat rno-miR-23b-3p miRNA glucocorticoid (GC) respiratory distress syndrome lung Glucocorticoids treatment upregulated 26997989 2446 Rat rno-miR-23b-5p miRNA angiotensin II (Ang II) cardiac hypertrophy H9C2 cells angiotensin II (Ang II) treatment upregulated 31103821 2447 Rat rno-miR-23c miRNA streptozocin (STZ) diabetic nephropathy (DN) rats renal tubular epithelial cells streptozotocin treatment downregulated 27964927 2448 Rat rno-miR-24 miRNA hypoxia cardiomyocyte apoptosis acute myocardial infarction (AMI) rat myocardium hypoxia induce upregulated 31378912 2449 Rat rno-miR-24 miRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues lipopolysaccharide (LPS) treatment LPS-induced lung injury in neonatal rats and resulted in significant downregulated of miR-24 expression. 30600184 2450 Rat rno-miR-24 miRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues lipopolysaccharide (LPS) treatment downregulated 30600184 2451 Rat rno-miR-24 miRNA taurolithocholic acid-3 sulfate acute pancreatitis (AP) rat pancreatic acinar AR42J cells taurolithocholic acid-3 sulfate treatment dysregulated 28849189 2452 Rat rno-miR-24 miRNA thyroglobulin (Tg) cell proliferation rat FRTL-5 thyroid cells Tg treatment upregulated 24479877 2453 Rat rno-miR-24 miRNA high-salt/low-potassium diet cerebral and renal vascular injuries stroke-prone spontaneously hypertensive rats high-salt/low-potassium diet treatment downregulated 23297375 2454 Rat rno-miR-24 miRNA alloxan diabetes mellitus (DM) plasma alloxan treatment downregulated 31508175 2455 Rat rno-miR-24 miRNA gambogic acid (GA) diabetes mellitus (DM) plasma Gallic acid (GA) treatment upregulated 31508175 2456 Rat rno-miR-24 miRNA high glucose (HG) diabetic cardiomyopathy (DCM) vascular smooth muscle cells (VSMCs) high glucose (HG) treatment downregulated 31005375 2457 Rat rno-miR-24 miRNA trimetazidine (TMZ) endothelial dysfunction plasma Trimetazidine (TMZ) treatment "Trimetazidine Increases Plasma MicroRNA-24 and MicroRNA-126 Levels and Improves Dyslipidemia, Inflammation and Hypotension in Diabetic Rats" 33680027 2458 Rat rno-miR-24 miRNA stimulation electrode epilepsy Adult male Sprague Dawley rats blood A bipolar stimulation electrode (distance between tips 500 ?m) was implanted in the angular bundle treatment dysregulated 24184920 2459 Rat rno-miR-24 miRNA lingguizhugan decoction (LGZG) heart failure (HF) heart tissues doxorubicin (DOX)-treated rats downregulated 31829159 2460 Rat rno-miR-24 miRNA hypoxia/reoxygenation (H/R) hypoxia/reoxygenation (H/R) injury cardiomyocytes hypoxia/reoxygenation (H/R) treatment H/R exposure decreased the expression of miR-24 in rat cardiomyocytes. 32728001 2461 Rat rno-miR-24 miRNA lycium barbarum polysaccharide (LBP) hypoxia-induced injury oxygen and glucose deprivation (OGD)-treated PC-12 cells Lycium barbarum polysaccharides (LBPs) treatment upregulated 31588805 2462 Rat rno-miR-24 miRNA oxygen glucose deprivation (OGD) hypoxia-induced injury PC-12 cells oxygen and glucose deprivation (OGD) treatment downregulated 31588805 2463 Rat rno-miR-24 miRNA bleomycin (BLM) idiopathic pulmonary fibrosis (IPF) bleomycin-injured rats lung tissues bleomycin (BLM) treatment downregulated 30446578 2464 Rat rno-miR-24 miRNA bleomycin (BLM) idiopathic pulmonary fibrosis (IPF) lung tissues bleomycin (BLM) treatment downregulated 30446578 2465 Rat rno-miR-24 miRNA isoflurane isoflurane-induced neurotoxicity hippocampus isoflurane treatment downregulated 31533001 2466 Rat rno-miR-24 miRNA lipopolysaccharide (LPS) myocardial injury H9c2 cells lipopolysaccharide (LPS) treatment downregulated 32181504 2467 Rat rno-miR-24 miRNA high glucose (HG) oxidative stress vascular smooth muscle cells (VSMCs) isolated from the thoracic aorta high glucose (HG) treatment downregulated 31539718 2468 Rat rno-miR-24 miRNA isoflurane oxidative stress H9c2 cells Isoflurane treatment downregulated 29627934 2469 Rat rno-miR-24 miRNA thrombin post-intracerebral hemorrhage (ICH) endothelial cells thrombin injection treatment thrombin reduces HIF-1¦Á degradation and initiates angiogenesis by increasing miR-24 32413855 2470 Rat rno-miR-24 miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment upregulated 21094214 2471 Rat rno-miR-24 miRNA isoproterenol ¦Â-adrenoceptor intervention rat heart tissues isoproterenol (ISO) treatment upregulated 22847192 2472 Rat rno-miR-24 miRNA hypoxia-inducible factor 1¦Á (HIF-1¦Á) cancer and inflammation rat cardiomyocytes HIF-1 treatment upregulated 23098654 2473 Rat rno-miR-24-1 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 2474 Rat rno-miR-24-1-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 2475 Rat rno-miR-24-1-5p miRNA hypoxia stroke middle cerebral artery occlusion (MCAO) Sprague-Dawley rat middle cerebral artery occlusion (MCAO) treatment upregulated 29113076 2476 Rat rno-miR-2424 miRNA bleomycin (BLM) lung fibrosis lung tissues bleomycin (BLM) treatment upregulated 33193637 2477 Rat rno-miR-24-2-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 2478 Rat rno-miR-24-3p miRNA estradiol benzoate (EB) chronic inflammatory diseases dorsolateral prostate estradiol benzoate (EB) treatment upregulated 33332750 2479 Rat rno-miR-24-3p miRNA doxorubicin (DOX) ischemia/reperfusion (I/R) injury rats cardiomyocytes doxorubicin treatment downregulated 27919821 2480 Rat rno-miR-24-3p miRNA hypoxia ischemia/reperfusion (I/R) injury H9C2 cardiomyocyte cell line hypoxia induce downregulated 30622671 2481 Rat rno-miR-24-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 2482 Rat rno-miR-2467-3p miRNA streptozocin (STZ) type 1 diabetes mellitus (T1DM) Urinary; blood; kidney tissues streptozotocin (STZ) treatment STZ-induced type 1 diabetic rat exhibit the reduction both of urinary and circulating miR-2467-3p 32050151 2483 Rat rno-miR-24a miRNA dexamethasone (DEX) acute diabete C2C12 myotubes dexamethasone (DEX) treatment downregulated 24336651 2484 Rat rno-miR-25 miRNA hypoxia cardiomyocytes proliferation and migration heart tissues; primary neonatal;adult cardiomyocytes hypoxia induce downregulated 31058341 2485 Rat rno-miR-25 miRNA repetitive transcranial magnetic stimulation (rTMS) focal cerebral ischemia Sprague-Dawley rats ischemic cortex rTMS treatment upregulated 25302788 2486 Rat rno-miR-25 miRNA emodin hypoxic brain injury hypoxia-induced PC-12 cells Emodin (EMO) treatment upregulated 31257935 2487 Rat rno-miR-25 miRNA hypoxia hypoxic brain injury PC-12 cells hypoxia induce downregulated 31257935 2488 Rat rno-miR-25 miRNA estradiol-17¦Â (E2) osteogenesis primary bone marrow mesenchymal stem cells from rats (rBMSCs) estradiol-17¦Â (E2) treatment upregulated 31089333 2489 Rat rno-miR-25 miRNA cholesterol-enriched diet oxidative stress Serum and tissue of rat cholesterol-enriched diet treatment upregulated 23722270 2490 Rat rno-miR-25 miRNA high amplitude mechanical stretching lung fibrosis alveolar type II (ATII) cells and lung fibroblasts high amplitude mechanical stretching treatment upregulated 31290711 2491 Rat rno-miR-25 miRNA lipopolysaccharide (LPS) sepsis-induced myocardial injury cardiac H9C2 cell line lipopolysaccharide (LPS) treatment downregulated 29440462 2492 Rat rno-miR-25 miRNA H2O2 spinal cord injury (SCI) PC-12 cells ?H2O2 treatment downregulated 28605990 2493 Rat rno-miR-25 miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment downregulated 21094214 2494 Rat rno-miR-25-3p miRNA hypoxia cyanotic congenital heart disease (CCHD) H9c2 cells hypoxia induce "SNHG14 and KLF4 were upregulated, whereas miR-25-3p was downregulated in hypoxia-induced H9c2 cells and cardiac tissues of patients with CCHD compared with their controls." 33278191 2495 Rat rno-miR-25-3p miRNA kainic acid (KA) epilepsy rats hippocampi; hippocampal neurons Kainic acid (KA) induction downregulated 31954517 2496 Rat rno-miR-25-3p miRNA magnesium-free extracellular fluid epilepsy rats hippocampi; hippocampal neurons Mg2+-free solution downregulated 31954517 2497 Rat rno-miR-25-3p miRNA hypoxia hypoxic/ischemic injury Male Sprague Dawley rats "were exposed to hypoxia (9.5-10% O2) for 1, 5, or 10 days" upregulated 29262398 2498 Rat rno-miR-25-5p miRNA serotonin smooth muscle cell differentiation brown Norway rat BMSCs serotonin treatment downregulated 24595007 2499 Rat rno-miR-25-5p miRNA insulin-like growth factor 1 (IGF-1) spinal cord injury (SCI) Neural stem cells were obtained from E15 fetal rat cerebral cortex cultured supernatant exosomes insulin growth factor-1 (IFG-1) treatment upregulated 31848325 2500 Rat rno-miR-26-3p miRNA gentamicin acute kidney injury (AKI) urine gentamicin treatment upregulated 33263228 2501 Rat rno-miR-26a miRNA methotrexate (MTX) arthritis rat macrophage line NR8383 cells methotrexate treatment downregulated 24423102 2502 Rat rno-miR-26a miRNA pristane (PS) arthritis NR8383 cells pristane treatment downregulated 24423102 2503 Rat rno-miR-26a miRNA CoCl2 cardiac arrest-induced brain damage Neural stem cells (NSCs) CoCl2 treatment to induce hypoxia injury model downregulated 30992390 2504 Rat rno-miR-26a miRNA H2O2 cytotoxicity RGC-5 cells H2O2 treatment downregulated 25757910 2505 Rat rno-miR-26a miRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) rat heart tissues streptozotocin (STZ) treatment downregulated 31389595 2506 Rat rno-miR-26a miRNA high glucose (HG) diabetic nephropathy (DN) Rat glomerular mesangial cells High glucose treatment upregulated 25797045 2507 Rat rno-miR-26a miRNA repeated binge-EtOH exposure ethanol addiction dorsal and ventral hippocampus of male Wistar rats repeated binge-EtOH exposure treatment different regulation 24416161 2508 Rat rno-miR-26a miRNA hypoxia ischemia/reperfusion (I/R) injury vascular tissues abdominal incision induce downregulated 30132885 2509 Rat rno-miR-26a miRNA oxygen glucose deprivation (OGD) myocardial infarction (MI) H9c2 cells oxygen glucose deprivation (OGD) treatment miR-26a was downregulated in oxygen-glucose deprivation (OGD)-treated H9c2 cells. 31990056 2510 Rat rno-miR-26a miRNA rotenone (ROT) parkinson's disease (PD) striatum of parkinsonian rats rotenone exposure treatment upregulated 30267378 2511 Rat rno-miR-26a miRNA antigen pulmonary inflammation plasma and lavaged lung antigen treatment upregulated 27075111 2512 Rat rno-miR-26a miRNA TGF-¦Â1 renal fibrosis renal tubular epithelial cells (NRK-52E) TGF-¦Â1 treatment downregulated 27874055 2513 Rat rno-miR-26a miRNA type II collagen rheumatoid arthritis (RA) cartilage tissues and inflammatory articular chondrocytes of RA rats type II collagen treatment downregulated 31267533 2514 Rat rno-miR-26a miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment upregulated 21094214 2515 Rat rno-miR-26a miRNA perfluorooctane sulfonic acid (PFOS) perfluorooctane sulfonate (PFOS)-induced toxic action rat liver tissue dams received 3.2 mg/kg PFOS in their feed from gestational day 1 (GD1) to postnatal day 7 (PND 12) treatment different expression 24420840 2516 Rat rno-miR-26a-1-5p miRNA H2O2 abdominal aortic aneurysm (AAA) primary vascular smooth muscle cells (VSMCs) H2O2 treatment downregulated 29956734 2517 Rat rno-miR-26a-5p miRNA ¦Â3-adrenoceptors(¦Â3-AR) inhibitor SR 59230A chronic heart failure (CHF) CHF rats 1 ml SR 59230A(85 mmoL/L in 0.9% saline)twice a day for seven weeks by intraperitoneal injection treatment upregulated 29926593 2518 Rat rno-miR-26a-5p miRNA liraglutide endothelial dysfunction aortic endothelial in diabetic rats liraglutide treatment upregulated 30863684 2519 Rat rno-miR-26a-5p miRNA hemin intracerebral haemorrhage (ICH) PC-12 cells hemin treatment downregulated 33000559 2520 Rat rno-miR-26b miRNA cisplatin (DDP) cisplatin (DDP)-induced nephrotoxicity renal tissue homogenate cisplatin treatment downregulated 32777238 2521 Rat rno-miR-26b miRNA pentoxifylline (PTX) cisplatin (DDP)-induced nephrotoxicity renal tissue homogenate pentoxifylline (PTX) treatment downregulated 32777238 2522 Rat rno-miR-26b miRNA intermittent hypoxia (IH) cognitive impairment rats hippocampus intermittent hypoxia (IH) treatment downregulated in hippocampus 28647595 2523 Rat rno-miR-26b miRNA high salt (HS) hypertension aorta of? rats high salt (HS) treatment downregulated 24161401 2524 Rat rno-miR-26b miRNA osteoactivin (OA) osteogenesis bone marrow-derived mesenchymal stem cells (BMSCs) Osteoactivin (OA) treatment upregulated 30768922 2525 Rat rno-miR-26b miRNA hypoxia pulmonary hypertension (PH) pulmonary arterial smooth muscle cells (PASMCs) hypoxia treatment Hypoxia-induced microRNA-26b inhibition contributes to hypoxic pulmonary hypertension via CTGF. 28816418 2526 Rat rno-miR-26b miRNA glycine subarachnoid hemorrhage (SAH) Cultured cortical neurons and microglia Glycine treatment upregulated 31612303 2527 Rat rno-miR-26b miRNA metformin (Met) type 2 diabetes mellitus (T2DM) brain tissues "orally and daily administrated 2.0 ml NSO, 100 mg metformin (MT)" downregulated in the brain 28505155 2528 Rat rno-miR-26b-3p miRNA rapamycin cardiac fibrosis heart tissues rapamycin (Rap) treatment upregulated 30647817 2529 Rat rno-miR-26b-3p miRNA herb-partitioned moxibustion ulcerative colitis (UC) UC rats colon tissues herb-partitioned moxibustion upregulated 28246536 2530 Rat rno-miR-26b-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia/reperfusion (I/R) injury PC12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment Our results showed that miR-26b-5p was downregulated in OGD/R-induced PC12 cells 33559506 2531 Rat rno-miR-26b-5p miRNA hypoxia hypoxic/ischemic injury Male Sprague Dawley rats "were exposed to hypoxia (9.5-10% O2) for 1, 5, or 10 days" upregulated 29262398 2532 Rat rno-miR-27 miRNA hypoxia glycolysis cardiomyocytes hypoxia treatment "Meanwhile, miR-27 and miR-195 were also upregulated in hypoxia-induced cardiomyocytes." 33819184 2533 Rat rno-miR-27 miRNA lipopolysaccharide (LPS) myocarditis H9c2 cells lipopolysaccharide (LPS) treatment downregulated 31576518 2534 Rat rno-miR-27 miRNA isoflurane oxidative stress H9c2 cells Isoflurane treatment upregulated 29627934 2535 Rat rno-miR-27a miRNA chronic brain hypoperfusion (CBH) apoptosis rats chronic brain hypoperfusion (CBH) treatment upregulated 26993299 2536 Rat rno-miR-27a miRNA nimodipine cognitive impairment brain tissues nimodipine treatment Nimodipine can improve CI after SAH in rats through the lncRNA NEAT1/miR-27a/MAPT axis. 32606599 2537 Rat rno-miR-27a miRNA high glucose (HG) diabetic nephropathy (DN) rat MC line (HBZY-1) rat MC line (HBZY-1) treatment upregulated 27184517 2538 Rat rno-miR-27a miRNA high glucose (HG) diabetic nephropathy (DN) NRK-52E cells high glucose (HG) treatment upregulated 32484208 2539 Rat rno-miR-27a miRNA omentin-1 diabetic nephropathy (DN) HBZY-1 cells omentin-1 treatment downregulated 30103116 2540 Rat rno-miR-27a miRNA cyclic mechanical stretch (CMS) cell proliferation primary rat aortic ECs 15% cyclic stretch upregulated in vascular smooth muscle cells -derived microparticles (VSMC-MPs) 28106155 2541 Rat rno-miR-27a miRNA stimulation electrode epilepsy Adult male Sprague Dawley rats blood A bipolar stimulation electrode (distance between tips 500 ?m) was implanted in the angular bundle treatment dysregulated 24184920 2542 Rat rno-miR-27a miRNA adreno-cortico-tropic-hormone (ACTH) hormonal regulation adrenals?tissues adreno-cortico-tropic-hormone (ACTH) treatment downregulated 24205079 2543 Rat rno-miR-27a miRNA estradiol-17¦Â (E2) hormonal regulation adrenals?tissues estradiol-17¦Â (E2) treatment downregulated 24205079 2544 Rat rno-miR-27a miRNA hypoxia ischemia/reperfusion (I/R) injury renal tissues "rats were anesthetized following the inhalation of 2% isoflurane. Subsequently, an abdominal incision was created, and the renal pedicle was clamped for 45 min with a microaneurysm clamp." downregulated 31173204 2545 Rat rno-miR-27a miRNA aerobic exercise left ventricular hypertrophy (LVH) left ventricular aerobic exercise training (AET) treatment upregulated 21709209 2546 Rat rno-miR-27a miRNA glucagon-like peptide-1 (GLP-1) lipotoxicity INS-1 pancreatic ¦Â-cell line derived from rat insulinoma 10 nmol/L GLP-1 for 24 h downregulated 29032333 2547 Rat rno-miR-27a miRNA porcine serum liver fibrosis rat liver tissues porcine serum treatment upregulation 24927615 2548 Rat rno-miR-27a miRNA lipopolysaccharide (LPS) microglial neuroinflammation primary microglial cells lipopolysaccharide (LPS) treatment downregulated 26971344 2549 Rat rno-miR-27a miRNA bilobalide (BB) myocardial infarction (MI) hypoxia-induced H9C2 cells bilobalide treatment upregulated 31322008 2550 Rat rno-miR-27a miRNA oxygen glucose deprivation (OGD) myocardial infarction (MI) H9C2 cells oxygen-glucose deprivation (OGD)-induce treatment downregulated 31322008 2551 Rat rno-miR-27a miRNA high fat diet (HFD) obesity adipose tissues high fat diet (HFD) feed "The obese rats in the HFD group, compared with rats in the NFD group, demonstrated a significant decrease in the expression of miR-27a (p < 0.05) and a significant increase in the expression of miR-143." 30411548 2552 Rat rno-miR-27a miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 2553 Rat rno-miR-27a miRNA endothelin-1 (ET-1) pulmonary hypertension (PH) primary cultured rat PASMC endothelin-1 (ET-1) treatment upregulated 28484848 2554 Rat rno-miR-27a miRNA H2O2 spinal cord injury (SCI) primary rat neurons H2O2 treatment downregulated 32679145 2555 Rat rno-miR-27a miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) microglial cells lipopolysaccharide (LPS) treatment miR-27a was lowly expressed in LPS-induced microglial cells. 31778769 2556 Rat rno-miR-27a miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) mouse primary microglial cells lipopolysaccharide (LPS) treatment "higher level of XIST and Smurf1, but lower level of miR-27a in SCI rats and lipopolysaccharide (LPS)-induced primary microglial cells." 31778769 2557 Rat rno-miR-27a miRNA dexamethasone (DEX) steroid-induced osteonecrosis of femoral head (ONFH) serum dexamethasone (DEX) treatment downregulated 30535438 2558 Rat rno-miR-27a miRNA dexamethasone (DEX) steroid-induced osteonecrosis of femoral head (ONFH) ONFH rats serum dexamethasone (DEX) treatment downregulated 30535438 2559 Rat rno-miR-27a miRNA high fat diet (HFD) weight gain end epididymal fat high fat diet (HFD) feed downregulated 29023027 2560 Rat rno-miR-27a miRNA dexamethasone (DEX) hormonal regulation adrenals?tissues dexamethasone (DEX) treatment downregulated 24205079 2561 Rat rno-miR-27a-3p miRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia treatment downregulated 31923741 2562 Rat rno-miR-27a-3p miRNA kainic acid (KA) epilepsy rat neuronal cells kainic acid (KA) treatment upregulated 31710596 2563 Rat rno-miR-27a-3p miRNA hypoxia hypoxia-induced injury H9c2 cell hypoxia induce downregulated 31923741 2564 Rat rno-miR-27a-3p miRNA FK506 osteogenesis rat bone marrow stromal cells (BMSCs) FK506 treatment downregulated 28560399 2565 Rat rno-miR-27a-3p miRNA bleomycin (BLM) lung fibrosis lung tissues bleomycin A5 treatment downregulated 32538751 2566 Rat rno-miR-27a-3p miRNA bleomycin (BLM) renal ischemia/reperfusion (I/R) injury NRK-52E cells hypoxia/reoxygenation (H/R) treatment upregulated 32084559 2567 Rat rno-miR-27a-3p miRNA glucocorticoid (GC) respiratory distress syndrome lung Glucocorticoids treatment upregulated 26997989 2568 Rat rno-miR-27a-3p miRNA phosphorus (Pi) vascular calcification (VC) A10 cells Pi treatment downregulated 33230462 2569 Rat rno-miR-27a-5p miRNA hypoxia acute myocardial infarction (AMI) rat cardiomyoblast cells (H9c2) hypoxia induce downregulated 31100777 2570 Rat rno-miR-27a-5p miRNA caerulein (Cae) acute pancreatitis (AP) Rat pancreatic acinar cell line AR42J caerulein (Cae) treatment downregulated 31106896 2571 Rat rno-miR-27a-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 2572 Rat rno-miR-27ab miRNA "hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)" neurotoxicity brain tissues of rats RDX at a dose(47 mg/kg) for 48 h treatment upregulated 25559034 2573 Rat rno-miR-27b miRNA angiotensin II (Ang II) cardiac fibrosis rat neonatal cardiac fibroblasts (CFs) angiotensin II (Ang II) treatment upregulated 31881012 2574 Rat rno-miR-27b miRNA collagenase intracerebral haemorrhage (ICH) rats striatum collagenase treatment downregulated 29050310 2575 Rat rno-miR-27b miRNA ischemic brain extract (IBE) ischemic injury "C6 rat astrocytoma cells, and primary rat MSCc (rMSCs)" IBE treatment downregulated 24999035 2576 Rat rno-miR-27b miRNA sevoflurane (SEV) learning deficits and abnormal social behaviors brain sevoflurane treatment upregulated 27973945 2577 Rat rno-miR-27b miRNA aerobic exercise left ventricular hypertrophy (LVH) left ventricular aerobic exercise training (AET) treatment upregulated 21709209 2578 Rat rno-miR-27b miRNA 4-vinylcyclohexene diepoxide (VCD) premature ovarian failure (POF) ovarian 4-vinylcyclohexene diepoxide (VCD) tretament upregulated 24188450 2579 Rat rno-miR-27b miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 2580 Rat rno-miR-27b miRNA puromycin aminonucleoside (PAN) podocyte protection non-human primates (NHPs) puromycin aminonucleoside (PAN) treatment "In NHP primary podocyte culture, significant downregulated of miR-27b was observed during treatment of puromycin aminonucleoside (PAN), a classic nephrotoxin" 30429458 2581 Rat rno-miR-27b miRNA endothelin-1 (ET-1) pulmonary hypertension (PH) primary cultured rat PASMC endothelin-1 (ET-1) treatment upregulated 28484848 2582 Rat rno-miR-27b miRNA sitagliptin renal interstitial inflammatory type II diabetic Goto-Kakizaki (GK) sitagliptin treatment upregulated 28652790 2583 Rat rno-miR-27b miRNA isoproterenol ¦Â-adrenoceptor intervention rat heart tissues isoproterenol (ISO) treatment downregulated 22847192 2584 Rat rno-miR-27b-3p miRNA guarana adipogenesis 3T3L1 cells guarana downregulated 28632199 2585 Rat rno-miR-27b-3p miRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissues streptozocin (STZ) treatment miR-27b-3p was decreased in DN rats and high-glucose-induced mice mesangial cells 30549040 2586 Rat rno-miR-27b-3p miRNA streptozocin (STZ) diabetic nephropathy (DN) rat kidney tissues streptozotocin (STZ) treatment downregulated 30549040 2587 Rat rno-miR-28 miRNA hypoxia cerebral ischemia injury (CII) Rat pheochomocytoma PC-12?cells hypoxia induce upregulated 31002779 2588 Rat rno-miR-28 miRNA tanshinone IIA (Tan IIA) cerebral ischemia injury (CII) hypoxia induced Rat pheochomocytoma PC-12?cells Tanshinone IIA treatment downregulated 31002779 2589 Rat rno-miR-28 miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment downregulated 27041227 2590 Rat rno-miR-28 miRNA hypoxia hypoxic brain injury PC-12 cell hypoxia induce "lncRNA H19 downregulated miR-28 expression, which in turn preventing SP1 from degradation by miR-28, and ultimately deactivated PDK/AKT and JAK/STAT signaling pathways." 30312698 2591 Rat rno-miR-28* miRNA aflatoxin B1 (AFB1) hepatocellular carcinoma (HCC) 7-week-old Fischer344 male rats liver aflatoxin B1 (AFB7) treatment upregulated 24472605 2592 Rat rno-miR-28-3p miRNA methamphetamine (METH) methamphetamine (METH) addiction brain tissues Methamphetamine (METH) treatment upregulated 32893733 2593 Rat rno-miR-28-5p miRNA phosgene acute lung injury (ALI) Lung-derived exosomes phosgene induce treatment upregulated 31707339 2594 Rat rno-miR-28-5p miRNA dexamethasone (DEX) cartilage injury articular cartilage dexamethasone (DEX) treatment miR-28-5p was downregulated compared with control group. 29207029 2595 Rat rno-miR-29 miRNA cigarette/nicotine cardiac dysfunction primary neonatal rat cardiac fibroblasts cigarette/nicotine exposure downregulated 32795172 2596 Rat rno-miR-29 miRNA aerobic exercise cardiac hypertrophy rat cardiac muscle tissues aerobic exercise training (AET) treatment aerobic training increase miR-29 expression in the heart 21447748 2597 Rat rno-miR-29 miRNA combined resistance-endurance (RE) training cardiovascular disease risk in women during menopause ovariectomy (OVX) rats heart tissues combined resistance-endurance (RE) training treatment upregulated 30766462 2598 Rat rno-miR-29 miRNA streptozocin (STZ) diabetes mellitus (DM) rat isolated dorsal root ganglion (DRG) neurons STZ treatment downregulated 24819309 2599 Rat rno-miR-29 miRNA TGF-¦Â erythroid cell differentiation Rat tubular epithelial cells (NRK52E) TGF-¦Â treatment downregulated 24103556 2600 Rat rno-miR-29 miRNA dexamethasone (DEX) excess of glucocorticoids (GCs) pregnant rats dexamethasone (DEX) treatment upregulated 24253049 2601 Rat rno-miR-29 miRNA hepatocyte growth factor (HGF) hepatic stellate cells (HSC) transdifferentiate into myofibroblasts rat hepatic stellate cells (HSC) Hepatocyte growth factor (HGF) treatment upregulated 21931759 2602 Rat rno-miR-29 miRNA TGF-¦Â hepatic stellate cells (HSC) transdifferentiate into myofibroblasts rat hepatic stellate cells (HSC) transforming growth factor-¦Â (TGF-¦Â) treatment downregulated 21931759 2603 Rat rno-miR-29 miRNA dexamethasone (DEX) maternal undernutrition (MUN) during pregnancy fetal rat lung fibroblasts dexamethasone (DEX) treatment Dexamethasone treatment of cultured fetal rat lung fibroblasts significantly induced miR-29 expression. 30088984 2604 Rat rno-miR-29 miRNA ginkgolide B (GB) myocardial infarction (MI) H9c2 cells Ginkgolide B treatment Hypoxia-induced apoptosis of cardiomyocytes is restricted by ginkgolide B-downregulated microRNA-29. 32295500 2605 Rat rno-miR-29 miRNA PPAR-¦Ãagonist myocardial ischemia/reperfusion (I/R) injury (MIRI) rat left ventricl tissue PPAR-¦Ãagonist treatment downregulated 20164119 2606 Rat rno-miR-29 miRNA cisplatin (DDP) nephrotoxicity male Sprague-Dawley (SD) rats urine cisplatin treatment upregulated 24863737 2607 Rat rno-miR-29 miRNA dexamethasone (DEX) vascular smooth muscle cell proliferation Blood samples dexamethasone (Dex) treatment upregulated 24253049 2608 Rat rno-miR-29 miRNA hepatitis C virus (HCV) hepatitis C virus (HCV) infection primary rat hepatocytes hepatitis C virus (HCV) infection downregulated 21606534 2609 Rat rno-miR-291a-3p miRNA "2,5-hexanedione (HD)" "2,5-hexanedione (HD) toxicity" spinal cord tissues "2,5-hexanedione (HD) treatment" upregulated 31760062 2610 Rat rno-miR-291a-3p miRNA dexamethasone (DEX) osteoporosis bone marrow-derived mesenchymal stem cells (BMSCs) dexamethasone (Dex) treatment DEX (DEX) inhibited cell viability and decreased the expression of miR-291a-3p in BMSCs. 31729834 2611 Rat rno-miR-291a-3p miRNA dexamethasone (DEX) osteoporosis Primary rat bone marrow-derived mesenchymal stem cells (BMSCs) dexamethasone (DEX) treatment "miRNA-291a-3p could improve the cell viability, osteogenic differentiation, and ALP activity, which are suppressed by DEX in BMSCs." 31729834 2612 Rat rno-miR-291b miRNA ethanol (EtOH) alcoholic liver disease (ALD) male Wistar rats Kupffer cells ethanol treatment upregulated in Kupffer cells 29142263 2613 Rat rno-miR-29-3p miRNA hypoxia-inducible factor 1¦Á (HIF-1¦Á) hypoxic pulmonary hypertension (HPH) pulmonary adventitial fibroblasts hypoxia-inducible factor-1 ¦Á treatment downregulated 25421979 2614 Rat rno-miR-294 miRNA hypoxia/reoxygenation (H/R) ischemia/reperfusion (I/R) injury mesenchymal stem cell (MSC) exosome hypoxia-reoxygenation (H/R) treatment upregulated 32719674 2615 Rat rno-miR-296 miRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment downregulated 30373531 2616 Rat rno-miR-296 miRNA acute stress (AS) and chronic stress (CS) stress-induced myocardial injury rat Rats were bound and suspended treatment upregulated 24669248 2617 Rat rno-miR-296-5p miRNA azoxymethane (AOM) colorectal cancer (CRC) colonic tissue of rat azoxymethane (AOM) treatment downregulated 23049818 2618 Rat rno-miR-297 miRNA angiotensin II (Ang II) cardiac hypertrophy neonatal rat cardiomyocytes (NCMs) angiotensin II (Ang II) treatment upregulated 28286226 2619 Rat rno-miR-297 miRNA perfluorooctane sulfonic acid (PFOS) neural dysfunctions rat brains perfluorooctane sulfonic acid (PFOS) treatment downregulated 22594572 2620 Rat rno-miR-297 miRNA lipopolysaccharide (LPS) septic shock Wistar rats serum LPS (10 mg/kg) treatment upregulated 24915805 2621 Rat rno-miR-297a miRNA valproic acid (VPA) cerebral ischemia injury (CII) rat cortical neuronal cells valproic acid treatment upregulated 22937209 2622 Rat rno-miR-298 miRNA hypoxia cortical injury rat cortex tisssues hypoxia treatment downregulated 23272113 2623 Rat rno-miR-298 miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cardiomyocytes hypoxia induce upregulated 31138376 2624 Rat rno-miR-298 miRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment downregulated 30373531 2625 Rat rno-miR-298 miRNA quercetin oxidative stress PC-12 cells Quercetin treatment downregulated 33343808 2626 Rat rno-miR-29a miRNA L©\arginine acute edematous pancreatitis (AEP) AR42J cell L-arginine treatment upregulated 27239114 2627 Rat rno-miR-29a miRNA NOX inhibitor VAS2870 acute ischemic stroke (AIS) tMCAO rats intravenous treatment with NOX inhibitor VAS2870 upregulated 27325364 2628 Rat rno-miR-29a miRNA deoxycholic acid (DCA) acute pancreatitis (AP) AR42J cells deoxycholic acid (DCA) treatment upregulated 30554587 2629 Rat rno-miR-29a miRNA VEGF-A cardiac fibrosis rat cardiac fibroblasts VEGF-A treatment downregulated 27060017 2630 Rat rno-miR-29a miRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment upregulated 31162869 2631 Rat rno-miR-29a miRNA angiotensin II (Ang II) cell proliferation and collagen synthesis cardiac fibroblasts of Sprague-Dawley rats angiotensin II (Ang II) treatment downregulated 28615545 2632 Rat rno-miR-29a miRNA infrasound cell proliferation and collagen synthesis cardiac fibroblasts of Sprague-Dawley rats pre-treat with Ang II infrasound treatment upregulated 28615545 2633 Rat rno-miR-29a miRNA epigallocatechin-3-gallate (EGCG) chronic renal injury cadmium (Cd) pretreated Wistar albino rats EGCG treatment "decreased miR-21 and miR-192, enhanced miR-29a/b/c in kidney samples" 27474435 2634 Rat rno-miR-29a miRNA follicle stimulating hormone (FSH) colorectal cancer (CRC) rat granulosa cells Follicle-stimulating hormone (FSH)treatment downregulated 20734245 2635 Rat rno-miR-29a miRNA streptozocin (STZ) diabetic cataract (DC) lens epithelial cells (LECs) Streptozotocin (STZ) treatment downregulated 28003969 2636 Rat rno-miR-29a miRNA captopril diabetic nephropathy (DN) diabetes rats kidney tissue captopril treatment upregulated 31433203 2637 Rat rno-miR-29a miRNA spironolactone diabetic nephropathy (DN) diabetes rats kidney tissue spironolactone treatment upregulated 31433203 2638 Rat rno-miR-29a miRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissue streptozotocin (STZ) treatment downregulated 31433203 2639 Rat rno-miR-29a miRNA high glucose (HG) diabetic retinopathy (DR) rat retinal M¨¹ller cells high glucose treatment downregulated 29409329 2640 Rat rno-miR-29a miRNA streptozocin (STZ) diabetic retinopathy (DR) rat retinal tissues streptozotocin (STZ) treatment downregulated 29409329 2641 Rat rno-miR-29a miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) hypothermic Circulatory Arrest (DHCA)-associated neural injury HT-22 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 29623838 2642 Rat rno-miR-29a miRNA hypoxic/ischemic hypoxic/ischemic injury rat kidneys tissue cells Hypoxia/Ischemia treatment upregulated 23596515 2643 Rat rno-miR-29a miRNA clamping both renal arteries ischemia/reperfusion (I/R) injury male rats clamping both renal arteries for 45 min upregulated 28129785 2644 Rat rno-miR-29a miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) primary astrocyte cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 30628716 2645 Rat rno-miR-29a miRNA corticotrophin releasing factor (CRF) receptor I antagonist (BMS-764459) hepatocellular carcinoma (HCC) rat liver cells "The corticotrophin releasing factor (CRF) receptor I antagonist, BMS-764459 treatment" "MiR-680 and miR-29a were identified as potential regulators and biomarkers of atypical CYP1A1 induction by regulating Abcc3, CYP3A and CYP2B as well as a number of AhR targeted genes" 23831372 2646 Rat rno-miR-29a miRNA 4-vinylcyclohexene diepoxide (VCD) premature ovarian failure (POF) ovarian 4-vinylcyclohexene diepoxide (VCD) tretament downregulated 24188450 2647 Rat rno-miR-29a miRNA swimming myocardial infarction (MI) myocardial-Infarcted Rats BR and RM ST consisted of 60 min/day/10 weeks and began four weeks after MI treatment upregulated 24642957 2648 Rat rno-miR-29a miRNA lipopolysaccharide (LPS) myocardial injury H9c2 cells lipopolysaccharide (LPS) treatment CRNDE/miR-29a/SIRT1 network regulated sepsis-induced myocardial injury. 32473249 2649 Rat rno-miR-29a miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment "Oip5-as1 suppresses miR-29a leading to activation of the SIRT1/AMPK/PGC1¦Á pathway, which attenuates mitochondria-mediated apoptosis during MI/R injury" 32468629 2650 Rat rno-miR-29a miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 myocardial cells hypoxia induce upregulated 31481517 2651 Rat rno-miR-29a miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) treatment upregulated 31481517 2652 Rat rno-miR-29a miRNA arbutin (ARB) optic nerve injury H2O2 treated rat primary retinal ganglion cells (RGCs) arbutin (ARB) treatment upregulated 30970524 2653 Rat rno-miR-29a miRNA H2O2 optic nerve injury rat primary retinal ganglion cells (RGCs) H2O2 treatment downregulated 30970524 2654 Rat rno-miR-29a miRNA "5,7,3',4'-tetramethoxyflavone (TMF)" osteoarthritis (OA) chondrocytes isolated from the rat cartilages "5,7,3',4'-tetramethoxyflavone (TMF) treatment" downregulated 31354246 2655 Rat rno-miR-29a miRNA 4-vinylcyclohexene diepoxide (VCD) premature ovarian failure (POF) rat POF tissues VCD treatment downregulated 24188450 2656 Rat rno-miR-29a miRNA american ginseng root's premature ovarian failure (POF) 4-Vinylcyclohexene diepoxide (VCD) treatment upregulated 25705687 2657 Rat rno-miR-29a miRNA sepsis renal injury ?kidney tissues cecal ligation puncture induced sepsis treatment the expression of miR-29a was prominently decreased in the sepsis-induced kidney injury model 31858562 2658 Rat rno-miR-29a miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC-12 cells lipopolysaccharides (LPS) treatment High NEAT1 levels can increase LPS-induced injury in PC-12 cells through the miR-29a/BCL2L11 pathway. 32776916 2659 Rat rno-miR-29a miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment downregulated 21094214 2660 Rat rno-miR-29a-3p miRNA endothelin-1 (ET-1) cardiac hypertrophy H9c2 endothelin-1 (ET-1) treatment downregulated 26992639 2661 Rat rno-miR-29a-3p miRNA Neuropeptide Y (NPY) cardiac hypertrophy Neonatal Rat Cardiomyocytes Neuropeptide Y (NPY) treatment NPY leads to downregulated of miR-29a-3p expression. 32297569 2662 Rat rno-miR-29a-3p miRNA muscle contraction diabetes mellitus (DM) muscle tissues "stimulated to contract in vitro for twitch tension analysis (0.5 Hz), 30 min later for tetanic analysis (100 Hz)" upregulated 28000044 2663 Rat rno-miR-29a-3p miRNA hypoxia hypoxic pulmonary hypertension (HPH) pulmonary adventitial fibroblast hypoxia treatment downregulated 25421979 2664 Rat rno-miR-29a-3p miRNA dexamethasone (DEX) hypoxic/ischemic brain damage (HIBD) hippocampus dexamethasone (DEX) treatment Dex treatment increased miR-29a-3p expression and decreased HDAC4 expression. 33232741 2665 Rat rno-miR-29a-3p miRNA high fat diet (HFD) osteogenesis rat bone marrow mesenchymal stem cells (BMSCs) high fat diet (HFD) feed downregulated 31168988 2666 Rat rno-miR-29a-3p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) oxygen-glucose deprivation/reoxygenation (OGD/R) injury PC-12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment MiR-29a-3p Enhances the Viability of Rat Neuronal Cells that Injured by Oxygen-Glucose Deprivation/Reoxygenation Treatment Through Targeting TNFRSF1A and Regulating NF-¦ÊB Signaling Pathway 33066952 2667 Rat rno-miR-29a-3p miRNA angiotensin II (Ang II) renal glomerular and tubulo-interstitial fibrosis renal tubules angiotensin II (Ang II) treatment downregulated 26700017 2668 Rat rno-miR-29a-3p miRNA yunpiheluo (YPHL) decoction type 2 diabetes mellitus (T2DM) Zucker diabetic fatty (ZDF) rats liver tissues Yunpiheluo (YPHL) decoction treatment "YPHL decoction attenuated IR in T2DM probably by down-regulating or maintaining the miR-29a-3p level, increasing the expression of IRS1 mRNA and its phosphorylated proteins, and regulating the expression of insulin receptor signaling-related proteins" 31128151 2669 Rat rno-miR-29a-3p miRNA cyclic mechanical stretch (CMS) vein graft restenosis Venous vascular smooth muscle cells Venous VSMCs exposed to 10%-1.25Hz cyclic stretch by using the Flexcell system were used to simulate arterial mechanical conditions in vitro. upregulated 31513704 2670 Rat rno-miR-29a-5p miRNA valproic acid (VPA) cell differentiation primary cultured neural stem cells (NSCs) valproate (VPA) treatment upregulated 29575035 2671 Rat rno-miR-29a-5p miRNA dehydroepiandrosterone (DHEA) polycystic ovarian syndrome (PCOS) rats' ovarian tissues DHEA treatment downregulated in rats' ovarian tissues 28673204 2672 Rat rno-miR-29b miRNA chitosan achilles tendon injury rats fibroblasts chitosan treatment upregulated 25674210 2673 Rat rno-miR-29b miRNA carvedilol alcohol addiction LV myocardium of rat carvedilol treatment upregulated 24086569 2674 Rat rno-miR-29b miRNA warfarin plus vitamin K calcific aortic valve disease (CAVD) aorta; plasma warfarin plus vitamin K treatment upregulated 32845082 2675 Rat rno-miR-29b miRNA tanshinone IIA (Tan IIA) cardiac fibrosis cardiac fibroblast (CF) Tanshinone IIA (TSN) treatment upregulated 25636075 2676 Rat rno-miR-29b miRNA complete freund's adjuvant (CFA) chronic pain L4-6 dorsal root ganglions (DRGs) complete Freund's adjuvant (CFA) treatment CFA leads to the upregulation of miR-29b level. 31980031 2677 Rat rno-miR-29b miRNA vitamin D receptor activators (VDRAs) chronic renal failure (CRF) nephrectomized Wistar rats equivalent doses of two VDRAs: calcitriol and paricalcitol treatment upregulated 28460073 2678 Rat rno-miR-29b miRNA epigallocatechin-3-gallate (EGCG) chronic renal injury cadmium (Cd) pretreated Wistar albino rats EGCG treatment "decreased miR-21 and miR-192, enhanced miR-29a/b/c in kidney samples" 27474435 2679 Rat rno-miR-29b miRNA hypoxia cortical injury rat cortex tisssues hypoxia treatment downregulated 23272113 2680 Rat rno-miR-29b miRNA streptozocin (STZ) diabetes mellitus (DM) the retinal ganglion cells (RGCs) ;the cells of the inner nuclear layer (INL) streptozotocin (STZ) injection treatment upregulated 21897745 2681 Rat rno-miR-29b miRNA captopril diabetic nephropathy (DN) diabetes rats kidney tissue captopril treatment upregulated 31433203 2682 Rat rno-miR-29b miRNA spironolactone diabetic nephropathy (DN) diabetes rats kidney tissue spironolactone treatment upregulated 31433203 2683 Rat rno-miR-29b miRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissue streptozotocin (STZ) treatment downregulated 31433203 2684 Rat rno-miR-29b miRNA high glucose (HG) diabetic retinopathy (DR) rat retinal M¨¹ller cells high glucose treatment downregulated 29409329 2685 Rat rno-miR-29b miRNA resveratrol diabetic retinopathy (DR) diabetic rats retina RSV (5 and 10 mg/kg/day)s at 1-7 months treatment upregulated 27311771 2686 Rat rno-miR-29b miRNA streptozocin (STZ) diabetic retinopathy (DR) rat retinal tissues streptozotocin (STZ) treatment downregulated 29409329 2687 Rat rno-miR-29b miRNA doxorubicin (DOX) doxorubicin (DOX)-induced cardiotoxicity Cardiomyocytes doxorubicin (Dox) treatment upregulated 30025410 2688 Rat rno-miR-29b miRNA angiotensin II (Ang II) epithelial-mesenchymal transition (EMT) spontaneously hypertensive rats (SHRs) and age-matched Wistar-Kyoto (WKY) rats angiotensin II (Ang II) treatment downregulated 25231273 2689 Rat rno-miR-29b miRNA cyclosporine A (CsA) gingival overgrowth gingival fibroblasts cyclosporine A treatment downregulated 26738448 2690 Rat rno-miR-29b miRNA 2-acetylaminofluorene hepatocellular carcinoma (HCC) liver tissue of rats 2-acetylaminofluorene treatment downregulated 22213190 2691 Rat rno-miR-29b miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) hypothermic Circulatory Arrest (DHCA)-associated neural injury HT-22 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 29623838 2692 Rat rno-miR-29b miRNA oxygen glucose deprivation (OGD) ischemic brain injury Hippocampal neuronal oxygen-glucose deprivation (OGD) treatment upregulated 27074745 2693 Rat rno-miR-29b miRNA curcumin (Cur) liver fibrosis HSC-T6 cells curcumin treatment upregulated 24138392 2694 Rat rno-miR-29b miRNA phenobarbital (PB) liver homeostasis liver tissues phenobarbital (PB) treatment upregulated 24157574 2695 Rat rno-miR-29b miRNA hypoxia/reoxygenation (H/R) myocardial dysfunction H9c2 cells hypoxia-reoxygenation (H/R) treatment hypoxia-reoxygenation (H/R) reduced the expression of miRNA-29b in cardiomyoblasts cultures. 30362585 2696 Rat rno-miR-29b miRNA indoxyl sulfate (IS) myocardial infarction (MI) cardiac fibroblasts indoxyl sulfate (IS) treatment downregulated 25896982 2697 Rat rno-miR-29b miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells hypoxia induce downregulated 30362585 2698 Rat rno-miR-29b miRNA lipopolysaccharide (LPS) myocarditis H9c2 cells lipopolysaccharide (LPS) treatment upregulated 29518613 2699 Rat rno-miR-29b miRNA oxygen glucose deprivation (OGD) neuron apoptosis rat primary hippocampal microglial cells oxygen-glucose deprivation (OGD) induce treatment downregulated 30742923 2700 Rat rno-miR-29b miRNA isoflurane oxidative stress H9c2 cells Isoflurane treatment upregulated 29627934 2701 Rat rno-miR-29b miRNA insulin-like growth factor 1 (IGF-1) post-stroke brain tissues Post-stroke ICV administration of IGF-1 to middle-aged female rats treatment downregulated 24618563 2702 Rat rno-miR-29b miRNA angiotensin II (Ang II) renal interstitial fibrosis (RIF) NRK-52E cells angiotensin II (Ang II) treatment downregulated 29568897 2703 Rat rno-miR-29b miRNA activated protein C(APC) sepsis rats blood and liver tissue activated protein C treatment aPC treatment coordinates beneficial cytoprotective effects during sepsis by modulating miRNA expression 22940033 2704 Rat rno-miR-29b miRNA silica silicosis RLE-6TN cells (rat type II alveolar epithelial cell line) supernatant of RAW264.7 cells stimulated by 50 mg/mL silica treatment downregulated 30529807 2705 Rat rno-miR-29b miRNA silica silicosis RLE-6TN cells treatment treatment Exposure of RLE-6TN cells to silica for 48 hr also resulted in EMT and a decrease in miR-29b gene expression 30529807 2706 Rat rno-miR-29b miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment upregulated 21094214 2707 Rat rno-miR-29b miRNA angiotensin II (Ang II) unilateral ureteral obstruction (UUO) NRK-52E cells angiotensin II (Ang II) treatment "?In this study, loss of miR-29b accompanied with increased epithelial-mesenchymal transition (EMT) was observed in renal tubules of mice after UUO and cultured NRK-52E cells exposed to AngII." 33742315 2708 Rat rno-miR-29b miRNA high inorganic phosphate (Pi) vascular calcification (VC) vascular smooth muscle high-phosphorous treatment upregulated 26187577 2709 Rat rno-miR-29b miRNA high inorganic phosphate (Pi) vascular calcification (VC) vascular smooth muscle high-phosphorous treatment lower levels of miR-133b and miR-211 and higher levels of miR-29b 26187577 2710 Rat rno-miR-29b-3p miRNA cholecalciferol arterial calcification Sprague Dawley rats calcified arterial tissues subcutaneous injection of a toxic dose of cholecalciferol downregulated in calcified arterial tissues 28164126 2711 Rat rno-miR-29b-3p miRNA "1,2-dichloroethane (1,2-DCE)" brain edema brain parenchyma and around the vessels of the cerebral cortex "1,2-dichloroethane (1,2-DCE) treatment" upregulated 31734271 2712 Rat rno-miR-29b-3p miRNA "1,2-dichloroethane (1,2-DCE)" brain edema brain cortex "1,2-dichloroethane (1,2-DCE) treatment" upregulated 31734271 2713 Rat rno-miR-29b-3p miRNA TGF-¦Â1 cardiac fibrosis Cardiac fibrosis TGF-¦Â1 treatment TGF-¦Â1 treatment dose-dependently curbed miR-29b-3p expression in CFs 32812641 2714 Rat rno-miR-29b-3p miRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment TUG1 functioned as a positive modulator of cardiac hypertrophy via sponging miR-29b-3p 31183682 2715 Rat rno-miR-29b-3p miRNA Na/K-ATPase chronic kidney disease (CKD) cardiac fibroblasts Na/K-ATPase treatment "a specific Na/K-ATPase signaling antagonist, pNaKtide, prevented ouabain-induced increases in collagen synthesis and decreases in miR-29b-3p expression in these cells" 26702050 2716 Rat rno-miR-29b-3p miRNA ketamine depression prefrontal cortex of the normal rats Ketamine treatment upregulated 30369596 2717 Rat rno-miR-29b-3p miRNA muscle contraction diabetes mellitus (DM) muscle tissues "stimulated to contract in vitro for twitch tension analysis (0.5 Hz), 30 min later for tetanic analysis (100 Hz)" downregulated 28000044 2718 Rat rno-miR-29b-3p miRNA fluorine combined with aluminum (FA) fluorine combined with aluminum (FA)-induced developmental neurotoxicity hippocampi fluorine combined with aluminum (FA) treatment upregulated 30033483 2719 Rat rno-miR-29b-3p miRNA hypoxia heart failure (HF) H9c2 cells hypoxia induce downregulated 30560317 2720 Rat rno-miR-29b-3p miRNA hypoxia heart failure (HF) H9c2 cells hypoxia induce downregulated 30560317 2721 Rat rno-miR-29b-3p miRNA angiotensin II (Ang II) hypertensive nephropathy (HN) rat renal artery endothelial cells (RRAECs) angiotensin II (Ang II) treatment upregulated 32346437 2722 Rat rno-miR-29b-3p miRNA hypoxia intestinal ischemia/reperfusion (I/R) injury IEC-6 cells hypoxia induce downregulated 31167039 2723 Rat rno-miR-29b-3p miRNA doxorubicin (DOX) ischemia/reperfusion (I/R) injury rats cardiomyocytes doxorubicin treatment upregulated 27919821 2724 Rat rno-miR-29b-3p miRNA particulate matter (PM2.5) ischemia/reperfusion (I/R) injury H9c2 cells PM2.5 exposure treatment LncRNA NR_136400 Suppresses Cell Proliferation and Invasion by Acting as a ceRNA of TUSC5 That Is Modulated by miR-8081 in Osteosarcoma 32100595 2725 Rat rno-miR-29b-3p miRNA metformin (Met) polycystic ovarian syndrome (PCOS) ovary tissues Metformin (Met) treatment upregulated 30989649 2726 Rat rno-miR-29c miRNA NOX inhibitor VAS2870 acute ischemic stroke (AIS) tMCAO rats intravenous treatment with NOX inhibitor VAS2870 upregulated 27325364 2727 Rat rno-miR-29c miRNA fastigial nucleus stimulation (FNS) brain injury left intracerebroventricular fastigial nucleus stimulation (FNS)treatment downregulated 25678279 2728 Rat rno-miR-29c miRNA exercise training (ET) cardiac remodeling and cardiac dysfunction obese Zucker rats carsiac "exercise training (AET) consisted of 10 weeks of 60-min swimming sessions, and 5 days/week" downregulated and miR-1 was upregulated compared with the control lean rats in carsiac 29138674 2729 Rat rno-miR-29c miRNA epigallocatechin-3-gallate (EGCG) chronic renal injury cadmium (Cd) pretreated Wistar albino rats EGCG treatment "decreased miR-21 and miR-192, enhanced miR-29a/b/c in kidney samples" 27474435 2730 Rat rno-miR-29c miRNA streptozocin (STZ) diabetic cataract (DC) lens epithelial cells (LECs) Streptozotocin (STZ) treatment downregulated 28003969 2731 Rat rno-miR-29c miRNA captopril diabetic nephropathy (DN) diabetes rats kidney tissue captopril treatment upregulated 31433203 2732 Rat rno-miR-29c miRNA spironolactone diabetic nephropathy (DN) diabetes rats kidney tissue spironolactone treatment upregulated 31433203 2733 Rat rno-miR-29c miRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissues streptozotocin (STZ) treatment upregulated 31364127 2734 Rat rno-miR-29c miRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissue streptozotocin (STZ) treatment downregulated 31433203 2735 Rat rno-miR-29c miRNA mithramycin A and decitabine glucocorticoids effects rat aortic smooth muscle cells mithramycin A and decitabine treatment upregulated 28801263 2736 Rat rno-miR-29c miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) hypothermic Circulatory Arrest (DHCA)-associated neural injury HT-22 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 29623838 2737 Rat rno-miR-29c miRNA nerve growth factor (Ngf) neurodegenerative diseases PC12 cells 100 ng/ml Ngf treatment different regulation 24492999 2738 Rat rno-miR-29c miRNA insulin-like growth factor 1 (IGF-1) post-stroke brain tissues Post-stroke ICV administration of IGF-1 to middle-aged female rats treatment downregulated 24618563 2739 Rat rno-miR-29c miRNA Specificity protein 1 (Sp1) renal fibrosis Rat proximal tubular epithelial cell (NRK-52E) Specificity protein 1 (Sp1) treatment downregulated 23806282 2740 Rat rno-miR-29c miRNA TGF-¦Â1 renal interstitial fibrosis (RIF) NRK-49F cells TGF-¦Â1 treatment MiR-29c expression was downregulated in TGF-¦Â1-treated NRK-49F cells 32346368 2741 Rat rno-miR-29c miRNA SiO2 trans-differentiation of pulmonary fibroblasts into myofibroblasts Fibroblasts which were co-cultured with pulmonary macrophages (NR8383) SiO2 treatment downregulated 31177707 2742 Rat rno-miR-29c-3p miRNA lipopolysaccharide (LPS) epilepsy CTX-TNA2 (CRL-2006) astrocyte cell line lipopolysaccharide (LPS) treatment downregulated 33776905 2743 Rat rno-miR-29c-3p miRNA pentylenetetrazol (PTZ) epilepsy dorsal hippocampus pentylenetetrazol treatment downregulated 33776905 2744 Rat rno-miR-29c-3p miRNA high glucose (HG) functions of cardiac fibroblasts primary cardiac fibroblasts high glucose (HG) treatment "MiR-29c-3p was downregulated, and STAT3 was upregulated in HG-induced cardiac fibroblasts." 32720796 2745 Rat rno-miR-29c-3p miRNA fish oil nonalcoholic fatty liver disease (NAFLD) high-fat high-cholesterol diet rats supplemented with fish oil (FOH) dysregulated 28691019 2746 Rat rno-miR-30 miRNA doxorubicin (DOX) cardiomyopathy Adult rat ventricular cardiomyocytes (ARVCM) doxorubicin treatment downregulated 25950484 2747 Rat rno-miR-30 miRNA angiotensin II (Ang II) chronic kidney disease (CKD) neonatal rat ventricular myocytes (NRVMs) angiotensin II (Ang II) treatment "?Furthermore, CKD-related detrimental factors, such as fibroblast growth factor-23 (FGF-23), uraemic toxin, angiotensin-II (Ang-II) and transforming growth factor-¦Â (TGF-¦Â), suppress cardiac miRNA-30 expression" 33848263 2748 Rat rno-miR-30 miRNA fibroblast growth factor 23 (FGF23) chronic kidney disease (CKD) neonatal rat ventricular myocytes (NRVMs) fibroblast growth factor-23 (FGF-23) treatment "?Furthermore, CKD-related detrimental factors, such as fibroblast growth factor-23 (FGF-23), uraemic toxin, angiotensin-II (Ang-II) and transforming growth factor-¦Â (TGF-¦Â), suppress cardiac miRNA-30 expression" 33848263 2749 Rat rno-miR-30 miRNA indoxyl sulfate (IS) chronic kidney disease (CKD) neonatal rat ventricular myocytes (NRVMs) indoxyl sulfate (IS) treatment "?Furthermore, CKD-related detrimental factors, such as fibroblast growth factor-23 (FGF-23), uraemic toxin, angiotensin-II (Ang-II) and transforming growth factor-¦Â (TGF-¦Â), suppress cardiac miRNA-30 expression" 33848263 2750 Rat rno-miR-30 miRNA TGF-¦Â chronic kidney disease (CKD) neonatal rat ventricular myocytes (NRVMs) TGF-¦Â treatment "?Furthermore, CKD-related detrimental factors, such as fibroblast growth factor-23 (FGF-23), uraemic toxin, angiotensin-II (Ang-II) and transforming growth factor-¦Â (TGF-¦Â), suppress cardiac miRNA-30 expression" 33848263 2751 Rat rno-miR-30 miRNA streptozocin (STZ) diabetic nephropathy (DN) glomeruli streptozotocin (STZ) treatment downregulated 33490186 2752 Rat rno-miR-30 miRNA angiotensin-converting enzyme 2 (ACE2) doxorubicin (DOX)-induced cardiotoxicity Primary cardiomyocytes and H9C2 cell line ACE2 (angiotensin-converting enzyme 2) treatment upregulated 27633839 2753 Rat rno-miR-30 miRNA ferulic acid (FA) liver fibrosis liver tissues ferulic acid treatment upregulated 32278740 2754 Rat rno-miR-30 miRNA gallic acid (GA) liver fibrosis liver tissues gallic acid treatment upregulated 32278740 2755 Rat rno-miR-30 miRNA folic acid renal fibrosis kidney tissues folic acid treatment downregulated 29158184 2756 Rat rno-miR-30 miRNA TGF-¦Â1 renal fibrosis rat kidney fibroblast cell NRK-49F and renal tubular epithelial cell NRK-52E TGF-¦Â1 treatment downregulated 29158184 2757 Rat rno-miR-30 miRNA TGF-¦Â1 renal fibrosis Rat kidney fibroblast cell NRK-49F and renal tubular epithelial cell NRK-52E TGF-¦Â1 treatment downregulated 29158184 2758 Rat rno-miR-30 miRNA angiotensin II (Ang II) WC-Co-induced carcinogenesis Cardiomyocyte angiotensin II (Ang II) treatment Angiotensin II induces downregulated of miR-30 in cardiomyocytes 23326547 2759 Rat rno-miR-300-3p miRNA artemisinin (ART) ventricular arrhythmias (VA) transverse aortic constriction (TAC) surgery treated rats left ventricle (LV) tissues artemisinin (ART) treatment upregulated 30595983 2760 Rat rno-miR-300-5p miRNA angiotensin II (Ang II) cardiac fibrosis and hypertension cardiac fibroblasts (CFs) of rats angiotensin II (Ang II) treatment downregulated 23007623 2761 Rat rno-miR-301a miRNA glycine neuronal cell injury cortical neurons Glycine treatment upregulated 27230112 2762 Rat rno-miR-301a miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 2763 Rat rno-miR-301b-3p miRNA mono-n-butyl phthalate (MBP) cell proliferation rat juvenile Sertoli cells (SCs) treat with 0.1mM MBP upregulated 29162477 2764 Rat rno-miR-302 miRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment upregulated 31845077 2765 Rat rno-miR-302a miRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment upregulated 31845077 2766 Rat rno-miR-302b miRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment upregulated 31845077 2767 Rat rno-miR-302b-3p miRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissues streptozotocin (STZ) treatment upregulated 32432759 2768 Rat rno-miR-302b-3p miRNA isoflurane neuronal cell injury primary hippocampal neurons Isoflurane (ISO) treatment ISO stimulation led to miR-302b-3p upregulation and neuronal injury. 33370590 2769 Rat rno-miR-302b-3p miRNA isoflurane neuronal cell injury rat hippocampal neurons Isoflurane (ISO) treatment ?We discovered that ISO stimulation led to miR-302b-3p upregulation and neuronal injury. 33370590 2770 Rat rno-miR-302c miRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment upregulated 31845077 2771 Rat rno-miR-302c miRNA high glucose (HG) mesothelial/epithelial-mesenchymal transition (MMT/EMT) mouse peritoneum high glucose peritoneal dialysate induce downregulated 30693641 2772 Rat rno-miR-302d miRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment upregulated 31845077 2773 Rat rno-miR-302e miRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment upregulated 31222747 2774 Rat rno-miR-302e miRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment MAGI1-IT1 functioned as a negative regulator in CH through inactivating Wnt/beta-catenin pathway via targeting miR-302e/DKK1 axis 31222747 2775 Rat rno-miR-30-3p miRNA hypoxia myocardial infarction (MI) H9C2 cells "cobalt chloride solution as 1000 ?mol/L, hypoxia for 12 hours" miRNA-30-3p had the effect of improving cell apoptosis induced by myocardial ischemia in vitro and in vivo studies by the regulation of the PTEN/PI3K/AKT pathway. 31131466 2776 Rat rno-miR-3068-3p miRNA glutamate ischemic stroke (IS) rat primary cortical neurons glutamate treatment upregulated 31792968 2777 Rat rno-mir-3074 miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 2778 Rat rno-miR-3074-5p miRNA palmitate pancreatic ¦Â-cell dysfunction INS-1E cells palmitate treatment lncEif4g2 is able to indirectly regulate the expression of CREB via targeting miR-3074-5p in INS-1E cells and mouse islets 32956705 2779 Rat rno-miR-3084a-3p miRNA cadmium (Cd) cadmium (Cd)-induced kidney injury renal cortex cadmium (Cd) treatment upregulated 29543730 2780 Rat rno-miR-3084c-3p miRNA cadmium (Cd) cadmium (Cd)-induced kidney injury renal cortex cadmium (Cd) treatment upregulated 29543730 2781 Rat rno-miR-30a miRNA paeonol (PAE) atherosclerosis (AS) vascular endothelial cells (VECs) paeonol treatment "ox-LDL decreased miR-30a and increased Beclin-1 expression, pretreatment with paeonol could reverse the process of regulation in dose-dependent manners" 29472864 2782 Rat rno-miR-30a miRNA triiodo-l-thyronine (T3) myocardial ischemia/reperfusion (I/R) injury (MIRI) primary cardiomyocyte of neonatal rats with hypoxia T3 treatment upregulated 25137026 2783 Rat rno-miR-30a miRNA phenylephrine (PE) cardiac hypertrophy H9c2 cells phenylephrine treatment downregulated 23660952 2784 Rat rno-miR-30a miRNA rapamycin cell senescence vascular smooth muscle cells (VSMCs) rapamycin treatment downregulated 30747228 2785 Rat rno-miR-30a miRNA "2,4,6-trinitrobenzene sulfonic acid (TNBS)" colitis male Wistar rats inflamed colon "2,4,6-trinitrobenzene sulfonic acid (TNBS)/ethanol treatment" downregulated in inflamed colon 28572713 2786 Rat rno-miR-30a miRNA caffeic acid diabetic nephropathy (DN) high-fat diet and streptozotocin-induced (HFD-STZ) diabetic rats caffeic acid (CA) treatment downregulated 28536471 2787 Rat rno-miR-30a miRNA S100A12 diabetic retinopathy (DR) Retinal microglia S100A12 treatment downregulated 31199706 2788 Rat rno-miR-30a miRNA TGF-¦Â1 insulin resistance (IR) peritoneal tissue in a rat TGF-¦Â1 treatment downregulated 24378208 2789 Rat rno-miR-30a miRNA cisplatin (DDP) hepatocellular carcinoma (HCC) HepS cells cis-dichloro-diamine platinum (cis-DDP) treatment upregulated 22157765 2790 Rat rno-miR-30a miRNA taxol hepatocellular carcinoma (HCC) HepS cells Taxol treatment upregulated 22157765 2791 Rat rno-miR-30a miRNA carbon tetrachloride (CCl4) liver fibrosis liver tissues carbon tetrachloride (CCl4) treatment downregulated 29587268 2792 Rat rno-miR-30a miRNA melatonin malignant arrhythmias older obese female rat hearts melatonin treatment downregulated 30446908 2793 Rat rno-miR-30a miRNA melatonin malignant arrhythmias high-sucrose-induced left ventricles of female rat hearts Melatonin treatment downregulated 30446908 2794 Rat rno-miR-30a miRNA omega-3 polyunsaturated fatty acids (¦Ø-3 PUFA) malignant arrhythmias older obese female rat hearts omega-3 polyunsaturated fatty acids treatment downregulated 30446908 2795 Rat rno-miR-30a miRNA omega-3 polyunsaturated fatty acids (¦Ø-3 PUFA) malignant arrhythmias high-sucrose-induced left ventricles of female rat hearts omega-3 polyunsaturated fatty acids treatment downregulated 30446908 2796 Rat rno-miR-30a miRNA substance P (SP) malignant arrhythmias left ventricles of female rat hearts sucrose treatment upregulated 30446908 2797 Rat rno-miR-30a miRNA sucrose malignant arrhythmias older obese female rat hearts sucrose treatment upregulated 30446908 2798 Rat rno-miR-30a miRNA angiotensin II (Ang II) myocardial injury rats primary cardiomyocytes angiotensin II (Ang II) treatment downregulated 25501305 2799 Rat rno-miR-30a miRNA epigallocatechin-3-gallate (EGCG) myocardial ischemia/reperfusion (I/R) injury (MIRI) hypoxia-induced H9c2 cardiomyocytes EGCG treatment upregulated 31029907 2800 Rat rno-miR-30a miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cardiomyocytes hypoxia induce downregulated 31029907 2801 Rat rno-miR-30a miRNA osthole myocardial ischemia/reperfusion (I/R) injury (MIRI) I/R in rat heart tissues and hypoxia/reoxygenation (H/R) in myocardial cells in vitro osthole treatment downregulated 31017665 2802 Rat rno-miR-30a miRNA H2O2 oxidative stress cardiovascular cells NRVCs and RAVSMCs H2O2 treatment downregulated 24612558 2803 Rat rno-miR-30a miRNA isoflurane and sevoflurane postoperative cognitive dysfunction (POCD) Wistar rats hippocampus exposed to isoflurane and sevoflurane for 2 or 4h downregulated in the hippocampus 28669717 2804 Rat rno-miR-30a miRNA insulin-like growth factor 1 (IGF-1) post-stroke brain tissues Post-stroke ICV administration of IGF-1 to middle-aged female rats treatment downregulated 24618563 2805 Rat rno-miR-30a miRNA grape seed proanthocyanidins (GSPs) prostatic deficits prostate orally given for 20 weeks upregulated 28499242 2806 Rat rno-miR-30a* miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment downregulated 27041227 2807 Rat rno-miR-30a-3p miRNA compound 21 (C21) cardiac hypertrophy Zucker diabetic fatty (ZDF) rats heart tissues Compound 21 (C21) treatment downregulated 30187136 2808 Rat rno-miR-30a-3p miRNA losartan cardiac hypertrophy Zucker diabetic fatty (ZDF) rats heart tissues losartan treatment downregulated 30187136 2809 Rat rno-miR-30a-3p miRNA compound 21 (C21) cardiac hypertrophy heart tissues Compound 21 (C21) treatment downregulated 30187136 2810 Rat rno-miR-30a-3p miRNA losartan cardiac hypertrophy heart tissues losartan treatment downregulated 30187136 2811 Rat rno-miR-30a-5p miRNA ¦Â3-adrenoceptors(¦Â3-AR) inhibitor SR 59230A chronic heart failure (CHF) CHF rats 1 ml SR 59230A(85 mmoL/L in 0.9% saline)twice a day for seven weeks by intraperitoneal injection treatment upregulated 29926593 2812 Rat rno-miR-30a-5p miRNA glucose glucotoxicity rat islets and INS-1 cells glucose treatment upregulated 23338554 2813 Rat rno-miR-30a-5p miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) treatment Hypoxia/reoxygenation (H/R) remarkably raised the level of miR-30a-5p in H9c2 cardiomyocytes. 33058540 2814 Rat rno-miR-30a-5p miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC-12 cells lipopolysaccharide (LPS) treatment LINC00707 alleviates LPS-induced inflammation and apoptosis in PC-12 cells by targeting miR-30a-5p/Neurod 1 31272297 2815 Rat rno-miR-30b miRNA amyloid-¦Â (A¦Â) 25-35 Alzheimer's disease (AD) PC12; C6 cells amyloid-¦Â (A¦Â) 25-35 treatment MALAT1 could promote neuronal recovery following AD through the miR-30b/CNR1 network and the PI3K/AKT signaling activation. 32976819 2816 Rat rno-miR-30b miRNA angiotensin II (Ang II) cardiomyocytes cell death rat neonatal cardiomyocytes angiotensin II (Ang II) treatment dysregulated 24178239 2817 Rat rno-miR-30b miRNA hypoxia/reoxygenation (H/R) cardiomyopathy H9C2 cell line hypoxia/re-oxygenation treatment downregulated 27294099 2818 Rat rno-miR-30b miRNA high glucose (HG) diabetic retinopathy (DR) rat retinal M¨¹ller cells (rMC-1) cells high glucose downregulated 28246353 2819 Rat rno-miR-30b miRNA high fat diet (HFD) nonalcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD) feed upregulated 30721562 2820 Rat rno-miR-30b miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 2821 Rat rno-miR-30b miRNA H2O2 oxidative stress cardiovascular cells NRVCs and RAVSMCs H2O2 treatment downregulated 24612558 2822 Rat rno-miR-30b miRNA grape seed proanthocyanidins (GSPs) prostatic deficits prostate orally given for 20 weeks upregulated 28499242 2823 Rat rno-miR-30b-3p miRNA triptolide (TPL) nephropathy blood and renal tissues rats with adriamycin-induced nephropathy treatment triptolide treatment reversed the increase in the expression of these two miRNAs 26078766 2824 Rat rno-miR-30b-5p miRNA estradiol-17¦Â (E2) osteogenesis primary bone marrow mesenchymal stem cells from rats (rBMSCs) estradiol-17¦Â (E2) treatment downregulated 31089333 2825 Rat rno-miR-30b-5p miRNA oxaliplatin peripheral neuropathic pain dorsal root ganglion (DRG) tissues oxaliplatin treatment downregulated 31054938 2826 Rat rno-miR-30b-5p miRNA glucocorticoid (GC) respiratory distress syndrome lung Glucocorticoids treatment upregulated 26997989 2827 Rat rno-miR-30c miRNA TGF-¦Â1 atrial fibrosis primary cultured neonatal cardiac fibroblasts (CFs) transforming growth factor-¦Â1 (TGF-¦Â1) treatment downregulated 29532993 2828 Rat rno-miR-30c miRNA vitamin D receptor activators (VDRAs) chronic renal failure (CRF) nephrectomized Wistar rats equivalent doses of two VDRAs: calcitriol and paricalcitol treatment upregulated 28460073 2829 Rat rno-miR-30c miRNA high glucose (HG) diabetic cardiomyopathy (DCM) cardiomyocytes high glucose treatment upregulated 27221738 2830 Rat rno-miR-30c miRNA palmitate diabetic cardiomyopathy (DCM) H9c2 cells and primary neonatal rat cardiomyocytes palmitate treatment downregulated 30635067 2831 Rat rno-miR-30c miRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) cardiomyocytes low-dose streptozotocin-high-fat diet treatment downregulated 25781190 2832 Rat rno-miR-30c miRNA pilocarpine epilepsy adult male rats brain tissue and heart tissue 50 days of pilocarpine treatment downregulated in heart tissue 24530830 2833 Rat rno-miR-30c miRNA hydrogen sulfide (H2S) ischemia/reperfusion (I/R) injury spinal cord infarct zone Hydrogen sulfide (H2S) treatment downregulated 26149869 2834 Rat rno-miR-30c miRNA angiotensin II (Ang II) liver fibrosis/cirrhosis hepatic stellate cells (HSCs) angiotensin II (Ang II) treatment downregulated 27142827 2835 Rat rno-miR-30c miRNA cisplatin (DDP) nephrotoxicity rats renal tubules and epithelial cell cisplatin treatment downregulated 28796263 2836 Rat rno-miR-30c miRNA nerve growth factor (Ngf) neurodegenerative diseases PC12 cells 100 ng/ml Ngf treatment different regulation 24492999 2837 Rat rno-miR-30c miRNA grape seed proanthocyanidins (GSPs) prostatic deficits prostate orally given for 20 weeks upregulated 28499242 2838 Rat rno-miR-30c miRNA TGF-¦Â1 renal fibrosis renal tubular epithelial cells (NRK-52E) TGF-¦Â1 treatment downregulated 27874055 2839 Rat rno-miR-30c miRNA oxygen glucose deprivation (OGD) spinal cord ischemia/reperfusion injury (SCII) PC12 cells oxygen-glucose deprivation (OGD) treatment upregulated 30776367 2840 Rat rno-miR-30c miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment upregulated 21094214 2841 Rat rno-miR-30c miRNA propranolol (PRO) ¦Â-adrenoceptor intervention rat heart propranolol (PRO) treatment upregulated 22847192 2842 Rat rno-miR-30c-1* miRNA grape seed procyanidin extract (GSPE) pancreatic islet injury rat islets grape seed procyanidin extract (GSPE)treatment "GSPE altered significantly the expression of miR-1249, miR-483, miR-30c-1*, and miR-3544." 23215023 2843 Rat rno-miR-30c-2* miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment downregulated 27041227 2844 Rat rno-miR-30c-5p miRNA ischemia/reperfusion (I/R) kidney damage Sprague-Dawley rats urine ischemia/reperfusion (I/R) treatment upregulated 28056546 2845 Rat rno-miR-30c-5p miRNA tert-butyl hydroperoxide (TBHP) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells tert- butyl hydroperoxide tBHP treatment MiR-30c-5p mediates the effects of panax notoginseng saponins in myocardial ischemia reperfusion injury by inhibiting oxidative stress-induced cell damage. 32036220 2846 Rat rno-miR-30c-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 2847 Rat rno-miR-30d miRNA valproic acid (VPA) autism spectrum disorder (ASD) amygdala valproic acid treatment upregulated 25986729 2848 Rat rno-miR-30d miRNA angiotensin II (Ang II) cardiac hypertrophy neonatal cardiomyocytes angiotensin II (Ang II) treatment upregulated 33860820 2849 Rat rno-miR-30d miRNA streptozocin (STZ) diabetes mellitus (DM) rats heart STZ treatment upregulated 25341033 2850 Rat rno-miR-30d miRNA SGLT-2 inhibitors diabetic cardiomyopathy (DCM) heart tissues SGLT-2 inhibitors treatment SGLT-2 inhibitors prevented heart function decline in diabetic rats by inhibiting miR-30d 32572932 2851 Rat rno-miR-30d miRNA TianMai Xiaoke tablet(TM) type 2 diabetes mellitus (T2DM) diabetic rats islet TM treatment upregulated 24812635 2852 Rat rno-miR-30d miRNA follicle stimulating hormone (FSH) colorectal cancer (CRC) rat granulosa cells Follicle-stimulating hormone (FSH)treatment downregulated 20734245 2853 Rat rno-miR-30d-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 2854 Rat rno-miR-30d-5p miRNA doxorubicin (DOX) ischemia/reperfusion (I/R) injury rats cardiomyocytes doxorubicin treatment upregulated 27919821 2855 Rat rno-miR-30d-5p miRNA fish oil nonalcoholic fatty liver disease (NAFLD) high-fat high-cholesterol diet rats supplemented with fish oil (FOH) dysregulated 28691019 2856 Rat rno-miR-30d-5p miRNA follicle stimulating hormone (FSH) polycystic ovarian syndrome (PCOS) rat cultured granulosa cells follicle stimulating hormone (FSH) treatment upregulated 31853272 2857 Rat rno-miR-30e miRNA isoproterenol cardiac fibrosis Sprague Dawley rats hearts ISO treatment downregulated in the hearts 28777253 2858 Rat rno-miR-30e miRNA oxygen glucose deprivation (OGD) ischemic brain injury Hippocampal neuronal oxygen-glucose deprivation (OGD) treatment upregulated 27074745 2859 Rat rno-miR-30e miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) rat myocardial tissues hypoxia/reoxygenation injury (H/R)? treatment Decreased miR-30e and increased SOX9 were found in myocardial tissues of MI/RI rats and H/R-treated cardiomyocytes. 33293097 2860 Rat rno-miR-30e miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation injury (H/R) treatment downregulated 33293097 2861 Rat rno-miR-30e miRNA high fat diet (HFD) obesity rats high fat diet (HFD) feed dysregulated 24517225 2862 Rat rno-miR-30e miRNA serum cell proliferation VSMCs isolated from normal aorta of adult male rats were stimulated with 10% serum treatment downregulated 28123167 2863 Rat rno-miR-30e miRNA schisandrin B (Sch B) tubulointerstitial fibrosis (TIF) TGF-¦Â1-treated NRK-52e cells Schisandrin B (Sch B) treatment upregulated 31697999 2864 Rat rno-miR-30e miRNA TGF-¦Â1 tubulointerstitial fibrosis (TIF) NRK-52e cells TGF-¦Â1 treatment downregulated 31697999 2865 Rat rno-miR-30e-3p miRNA rapamycin cardiac fibrosis heart tissues rapamycin (Rap) treatment upregulated 30647817 2866 Rat rno-miR-31 miRNA atorvastatin cardiac hypertrophy chronic intermittent hypoxia (CIH)-treated H9c2 cells atorvastatin treatment downregulated 30074205 2867 Rat rno-miR-31 miRNA hypoxia cardiac hypertrophy H9c2 cells chronic intermittent hypoxia (CIH) induce upregulated 30074205 2868 Rat rno-miR-31 miRNA hypoxia myocardial infarction (MI) heart tissues MI was induced by ligation of the left anterior descending coronary artery (LAD) upregulated 28865712 2869 Rat rno-miR-31 miRNA isoflurane and sevoflurane postoperative cognitive dysfunction (POCD) Wistar rats hippocampus exposed to isoflurane and sevoflurane for 2 or 4h downregulated in the hippocampus 28669717 2870 Rat rno-miR-31-5p miRNA doxorubicin (DOX) doxorubicin (DOX)-induced cardiotoxicity H9c2 cells doxorubicin (Dox) treatment downregulated 32135167 2871 Rat rno-miR-31a-5p miRNA high fat diet (HFD) aging-related non-alcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD) feed downregulated 31899128 2872 Rat rno-miR-31a-5p miRNA angiotensin II (Ang II) heart failure (HF) cardiac H9C2 cell line angiotensin II (Ang II) treatment downregulated 29286111 2873 Rat rno-miR-31a-5p miRNA angiotensin II (Ang II) heart failure (HF) H9C2 cell line angiotensin II (Ang II) treatment downregulated 29286111 2874 Rat rno-miR-31a-5p miRNA methamphetamine (METH) methamphetamine (METH) addiction brain tissues Methamphetamine (METH) treatment upregulated 32893733 2875 Rat rno-miR-31b miRNA methamphetamine (METH) methamphetamine (METH) addiction brain tissues Methamphetamine (METH) treatment upregulated 32893733 2876 Rat rno-miR-31c miRNA H2O2 oxidative stress cardiovascular cells NRVCs and RAVSMCs H2O2 treatment downregulated 24612558 2877 Rat rno-miR-32 miRNA streptozocin (STZ) liver fibrosis liver tissue streptozotocin (STZ) treatment upregulated 30816482 2878 Rat rno-miR-320 miRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) Wistar rats left ventricle (LV) STZ treatment downregulated 28199183 2879 Rat rno-miR-320 miRNA high glucose (HG) diabetic retinopathy (DR) M¨¹ller cells high glucose (HG) treatment DR patients exhibited significantly increased expression of serum LncRNA-OGRU compared with normal individuals. Streptozotocin (STZ)-challenged rats with DR also had higher OGRU expression in retinas 33762162 2880 Rat rno-miR-320 miRNA ethylene glycol monomethyl ether (EGME) hyperglycemia ?testicle of rat Ethylene glycol monomethyl ether (EGME) treatment "miR-449a and miR-92a decreased obviously and, miR-320, miR-134 and miR-188 increased" 22008535 2881 Rat rno-miR-320 miRNA high salt (HS) hypertension aorta of? rats high salt (HS) treatment upregulated 24161401 2882 Rat rno-miR-320 miRNA edaravone (ED) intestinal mucosa barrier dysfunction after burn injury intestinal mucosal tissue injury in burned rats edaravone (ED) treatment upregulated 31829167 2883 Rat rno-miR-320 miRNA oxygen glucose deprivation (OGD) ischemic heart disease (IHD) H9c2 cells oxygen and glucose deprivation (OGD) treatment Overexpressed circRNA-DENND4C in H9c2 cells attenuated OGD/R-induced injuries by the downregulated of miR-320 through the ERK and mTOR activation 33090893 2884 Rat rno-miR-320 miRNA verapamil male fertility testis verapamil treatment downregulated 32725937 2885 Rat rno-miR-320 miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cardiac myocytes hypoxia induce upregulated 29521436 2886 Rat rno-miR-320 miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia induce upregulated 30181740 2887 Rat rno-miR-320 miRNA insulin myocardial ischemia/reperfusion (I/R) injury (MIRI) hypoxia-induced H9C2 cardiac myocytes insulin treatment downregulated 29521436 2888 Rat rno-miR-320 miRNA luteolin renal ischemia/reperfusion (I/R) injury ischemia-reperfusion (I/R) injury rats kidney tissues luteolin treatment downregulated 31089916 2889 Rat rno-miR-3202 miRNA cigarette smoke (CS) chronic obstructive pulmonary disease (COPD) rats bronchia cigarette smoke (CS) treatment downregulated in bronchia 29208459 2890 Rat rno-miR-320-3p miRNA morphine myocardial hypoxia/reoxygenation (H/R) injury H9c2 cells Morphine pre-conditioning (MPC) The expression of miR-320-3p in the MPC+H/R group was significantly lower than that in the H/R group. 32468068 2891 Rat rno-miR-320-5p miRNA ¦Â3-adrenoceptors(¦Â3-AR) inhibitor SR 59230A chronic heart failure (CHF) CHF rats 1 ml SR 59230A(85 mmoL/L in 0.9% saline)twice a day for seven weeks by intraperitoneal injection treatment upregulated 29926593 2892 Rat rno-miR-320a miRNA insulin polycystic ovarian syndrome (PCOS) KGN cells insulin treatment upregulated 28849208 2893 Rat rno-miR-320b miRNA insulin-like growth factor 1 (IGF-1) post-stroke brain tissues Post-stroke ICV administration of IGF-1 to middle-aged female rats treatment downregulated 24618563 2894 Rat rno-miR-320c miRNA streptozocin (STZ) type 1 diabetes mellitus (T1DM) INS-1 cells streptozocin (STZ) treatment Secretions of miR-320c was significantly increased in streptozotocin-treated INS-1 cells 29370422 2895 Rat rno-miR-322 miRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) Wistar rats left ventricle (LV) STZ treatment upregulated 28199183 2896 Rat rno-miR-322 miRNA carbon tetrachloride (CCl4) liver fibrosis liver tissues carbon tetrachloride (CCl4) treatment upregulated 33333053 2897 Rat rno-miR-322 miRNA carbon tetrachloride (CCl4) liver fibrosis rat liver tissue CCl4 treatment "miR-322/424 level in liver cirrhosis patients, mouse liver fibrosis induced by CCl4?and BDL, and rat liver fibrosis induced by CCl4?and dimethylnitrosamine was increased." 33333053 2898 Rat rno-miR-322-5p miRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment downregulated 32436661 2899 Rat rno-miR-322-5p miRNA high glucose (HG) diabetic cardiomyopathy (DCM) rat vascular smooth muscle cells (VSMCs) high glucose downregulated 28536423 2900 Rat rno-miR-322-5p miRNA bortezomib peripheral neuropathy PC12 cells bortezomib treatment downregulated 31979371 2901 Rat rno-miR-322-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 2902 Rat rno-miR-323 miRNA hypoxia cerebral infarction (CI) PC12 cells hypoxia induce upregulated 30535466 2903 Rat rno-miR-323 miRNA oxygen glucose deprivation (OGD) neuronal cell death primary hippocampal neuron oxygen-glucose deprivation (OGD) treatment upregulated 26617783 2904 Rat rno-miR-323-3p miRNA H2O2 myocardial infarction (MI) H9c2 cells H2O2 treatment downregulated 32633390 2905 Rat rno-miR-323a-3p miRNA angiotensin II (Ang II) cardiac fibrosis rat cardiac fibroblasts (CFs) angiotensin II (Ang II) treatment MiR-323a-3p was found upregulated in CFs cultured with Angiotensin ¢ò (Ang ¢ò). 30551487 2906 Rat rno-miR-324 miRNA aerobic exercise parkinson's disease (PD) brain tissues aerobic exercise training (AET) treatment downregulated 31309116 2907 Rat rno-miR-324-3p miRNA 2-imidazolidinethione anorectal malformations (ARM) Intestinal epithelial cells; IECs and anorectal tissues 2-imidazolidinethione treatment "Rno_circ_0005139 influences cell proliferation and apoptosis by acting as a miR-324-3p sponge, thereby downregulating Wnt5a in ARM." 32848333 2908 Rat rno-miR-324-3p miRNA high fat diet (HFD) cardiac remodeling heart tissues high fat diet (HFD) feed upregulated 29884823 2909 Rat rno-miR-324-3p miRNA hypoxia cortical injury rat cortex tisssues hypoxia treatment downregulated 23272113 2910 Rat rno-miR-324-3p miRNA streptozocin (STZ) diabetic retinopathy (DR) retinas tissues streptozotocin treatment downregulated 31430717 2911 Rat rno-miR-324-3p miRNA ¦Ä-opioid receptor (DOR) hypoxic/ischemic injury hearts ¦Ä-opioid receptor (DOR) activation treatment upregulated 27576463 2912 Rat rno-miR-324-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) acute myocardial infarction (AMI) rat ventricular cardiomyocytes (NRCMs) oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 31622017 2913 Rat rno-miR-324-5p miRNA oxygen glucose deprivation (OGD) ischemic stroke (IS) primary rat neurons oxygen-glucose deprivation (OGD) induce treatment downregulated 31885705 2914 Rat rno-miR-324-5p miRNA oxygen glucose deprivation (OGD) ischemic stroke (IS) primary rat neurons oxygen-glucose deprivation (OGD) treatment Downregulated miRNA-324-5p aggravates neuronal injury induced by oxygen-glucose deprivation via modulating RAN 31885705 2915 Rat rno-miR-324-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) Neonatal rat ventricular cardiomyocytes (NRCMs) oxygen-glucose deprivation and reoxygenation (OGD/R) treatment Inhibition of the LncRNA Gpr19 attenuates ischemia-reperfusion injury after acute myocardial infarction by inhibiting apoptosis and oxidative stress via the miR-324-5p/Mtfr1 axis. 31622017 2916 Rat rno-miR-325-3p miRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia induce "The expression levels of MEG3 and TRPV4 were significantly increased, whereas miR-325-3p expression levels were significantly decreased in hypoxic H9c2 cells compared with normoxic H9c2 cells." 33179099 2917 Rat rno-miR-325-5p miRNA neonatal colonic inflammation (NCI) chronic visceral hypersensitivity colon-related dorsal root ganglia (DRGs) neonatal colonic inflammation (NCI) induce downregulated 30980241 2918 Rat rno-miR-326 miRNA alcohol fetal alcohol exposure (FAE) pregnant Fisher 344 rats pituitary liquid diet containing 6.7% alcohol between gestational days 7-21 (AF) upregulated 28710248 2919 Rat rno-miR-326 miRNA formaldehyde formaldehyde inducted immune/inflammation rats were exposed to formaldehyde treatment upregulated 24304932 2920 Rat rno-miR-326 miRNA oxygen glucose deprivation (OGD) hypoxic/ischemic brain damage (HIBD) PC-12 cells oxygen glucose deprivation (OGD) treatment The expression levels of miR-326 was significantly lower in the HIBD group. 32228617 2921 Rat rno-miR-326-3p miRNA cadmium (Cd) kidney damage NRK-52E cells cadmium (Cd) treatment miR-122-5p and miR-326-3p might enhance cadmium-induced NRK-52E cell apoptosis through downregulating PLD1 expression. 32697411 2922 Rat rno-miR-326-3p miRNA cadmium (Cd) renal toxic "NRK-52E cells, rat kidney, serum and urine samples" cadmium (Cd) treatment upregulated 31626960 2923 Rat rno-miR-326-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia/reperfusion (I/R) injury primary rat cortical neurons oxygen-glucose deprivation and reoxygenation (OGD/R) treatment "Mfn2 and miR-326-5p were reduced, and STAT3 was elevated in OGD-treated neurons and brain tissues of MCAO rats" 33877455 2924 Rat rno-miR-327 miRNA angiotensin II (Ang II) cardiac hypertrophy and fibrosis rat cardiac fibroblasts angiotensin II (Ang II) treatment miR-327 levels in fibroblasts were increased. 29393356 2925 Rat rno-miR-327 miRNA oxygen lung injury pregnant rats lung tissue inspired oxygen of 10.5 or 23% for two days treatment downregulated 25120593 2926 Rat rno-miR-327 miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells H9c2 cells were exposed to hypoxia for 4?hr and reoxygenation for 12?hr to mimic I/R injury upregulated 31587299 2927 Rat rno-miR-327 miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H92c cells hypoxia/reoxygenation (H/R) treatment Inhibition of microRNA-327 ameliorates ischemia/reperfusion injury-induced cardiomyocytes apoptosis through targeting apoptosis repressor with caspase recruitment domain 31587299 2928 Rat rno-miR-328 miRNA doxycycline atrial fibrillation (AF) heart tissues doxycycline treatment downregulated 30470910 2929 Rat rno-miR-328 miRNA doxycycline atrial fibrillation (AF) heart sissues doxycycline treatment upregulated 30470910 2930 Rat rno-miR-328 miRNA 60 mmHg of pressure renal fibrosis rat renal tubular cells (NRK-52E) culture under 60 mmHg of pressure treatment downregulated 24919189 2931 Rat rno-miR-328a miRNA high fat diet (HFD) erectile dysfunction (ED) rats high fat diet (HFD) feed corpus cavernosum (CC) 28970082 2932 Rat rno-miR-328a-3p miRNA cold cold stress rats serum cold conditions (4¡æ for 12h) downregulated 28477904 2933 Rat rno-miR-328a-3p miRNA fish oil nonalcoholic fatty liver disease (NAFLD) high-fat high-cholesterol diet rats supplemented with fish oil (FOH) dysregulated 28691019 2934 Rat rno-miR-328a-5 miRNA cadmium (Cd) cadmium (Cd)-induced reproductive toxicity testes cadmium (Cd) treatment "miR-328a-5p was significantly increased only in the 2.0 mg/kg Cd treatment group at PND 21. at PND 56, the expression of miR-328a-5p decreased in all of the Cd treatment groups (P < 0.05 and P < 0.01) and decreased to 0.4 in the 2.0 mg/kg Cd treatment group." 31654709 2935 Rat rno-miR-329 miRNA comfrey tumorigenesis rat liver comfrey treatment downregulated 21370286 2936 Rat rno-miR-329-3p miRNA estradiol benzoate (EB) and testosterone (T)/E chronic inflammatory diseases dorsolateral prostate estradiol benzoate (EB) and testosterone (T)/E treatment downregulated 33332750 2937 Rat rno-miR-32d miRNA H2O2 oxidative stress cardiovascular cells NRVCs and RAVSMCs H2O2 treatment downregulated 24612558 2938 Rat rno-miR-33 miRNA grape seed proanthocyandin extract (GSPE) dysregulated fatty acid and cholesterol metabolism rat liver cells grape seed proanthocyanidins extracts (GSPE) treatment downregulated 22965541 2939 Rat rno-miR-33 miRNA icariside II (ICA II) erectile dysfunction (ED) Adipose derived stem cells (ADSCs) Icariside II (ICA II) treatment ICA II promoted the differentiation of ADSCs to SCs through downregulating miR-33. 32066039 2940 Rat rno-miR-33 miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment downregulated 27041227 2941 Rat rno-miR-33 miRNA estradiol metabolic effects of estrogen liver tissues estradiol treatment upregulated 32045601 2942 Rat rno-miR-33 miRNA arterial mechanical stretch neointimal hyperplasia Sprague-Dawley rats venous smooth muscle cells (SMCs) exposed to a 10%-1.25 Hz cyclic arterial stretch downregulated 28137944 2943 Rat rno-miR-330 miRNA lipopolysaccharide (LPS) disseminated intravascular coagulation (DIC) liver tissues lipopolysaccharide (LPS) treatment upregulated 24806323 2944 Rat rno-miR-330 miRNA fructose kidney damage rats kidney cortex fructose treatment downregulated in kidney cortex 28205387 2945 Rat rno-miR-330 miRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment upregulated 30373531 2946 Rat rno-miR-330-3p miRNA high glucose (HG) gestational diabetes mellitus (GDM) INS-1 cells high glucose (HG) treatment The miR-330-3p expression level positively correlated with blood glucoseand and it was highly expressed in glucose-treated INS-1 cells. 32202040 2947 Rat rno-miR-330-5p miRNA H2O2 adipogenesis mesenchymal stem cells (MSCs) H2O2 treatment downregulated 30015907 2948 Rat rno-miR-330-5p miRNA high fat diet (HFD) cardiac remodeling heart tissues high fat diet (HFD) feed upregulated 29884823 2949 Rat rno-miR-330-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 2950 Rat rno-miR-331-3p miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC-12 cells lipopolysaccharide (LPS) treatment SOX2OT was elevated in SCI rat and cell models. 33340723 2951 Rat rno-miR-331-5p miRNA ketamine drug addiction hippocampus tissues ketamine treatment downregulated 29476799 2952 Rat rno-miR-331-5p miRNA rhynchophylline drug addiction ketamine-addicted rats hippocampus tissues rhynchophylline treatment downregulated 29476799 2953 Rat rno-miR-335 miRNA hypoxia acute ischemic stroke (AIS) brain tissues Middle cerebral artery occlusion (MCAO) treatment downregulated 30747210 2954 Rat rno-miR-335 miRNA high fat diet (HFD) aging-related non-alcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD) feed upregulated 31899128 2955 Rat rno-miR-335 miRNA methane diabetic retinopathy (DR) Retinal?tissues methane treatment upregulated 26363454 2956 Rat rno-miR-335 miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) treatment miR-335 was significantly downregulat- ed in H/R-exposed cardiomyocytes. 30662652 2957 Rat rno-miR-335 miRNA glucocorticoid (GC) osteonecrosis of femoral head (ONFH) rat femoral head bone microvascular endothelial cells (BMECs) glucocorticoids treatment ICA could regulate the overexpression of miRNA-335 induced by glucocorticoids. 32911026 2958 Rat rno-miR-335 miRNA icariin (ICA) osteonecrosis of femoral head (ONFH) rat femoral head bone microvascular endothelial cells (BMECs) Icariin (ICA) treatment ICA could regulate the overexpression of miRNA-335 induced by glucocorticoids. 32911026 2959 Rat rno-mir-335 miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 2960 Rat rno-miR-335 miRNA methylprednisolone steroid-induced osteonecrosis of femoral head (ONFH) bone microvascular endothelial cells (BMECs) methylprednisolone treatment upregulated 29408208 2961 Rat rno-miR-335-3p miRNA chronic normobaric hypoxia (CNH) pulmonary arterial hypertension (PAH) lung tissues chronic normobaric hypoxia (CNH) treatment MiR-335-3p was significantly increased in lung tissue of CNH-induced PAH mice. 32015687 2962 Rat rno-miR-33-5p miRNA fish oil nonalcoholic fatty liver disease (NAFLD) high-fat high-cholesterol diet rats supplemented with fish oil (FOH) dysregulated 28691019 2963 Rat rno-miR-336-5p miRNA insert a cannula connected with a saline container into the anterior chamber acute ocular hypertension (AOH) adult albino rats retinal ganglion cells (RGCs) and microglial cells insert a cannula connected with a saline container into the anterior chamber upregulated 27535721 2964 Rat rno-miR-337 miRNA "bone matrix gelatin ,collagen,and pristane" chondrogenesis rat cartilage "bone matrix gelatin ,collagen,and pristane treatment" downregulated 22425884 2965 Rat rno-miR-337 miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) neonatal rat ventricular cardiomyocytes hypoxia induce upregulated 31220137 2966 Rat rno-miR-337 miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) primary cultured astrocytes (AST) lipopolysaccharide (LPS) treatment upregulated 30257365 2967 Rat rno-miR-337 miRNA mulberrin (Mul) spinal cord injury (SCI) Spinal cord injury (SCI) rats spinal cord tissue Mulberrin (Mul) treatment downregulated 30257365 2968 Rat rno-miR-337 miRNA mulberrin (Mul) spinal cord injury (SCI) LPS-treated primary cultured astrocytes (AST) Mulberrin (Mul) treatment downregulated 30257365 2969 Rat rno-miR-337-3p miRNA CoCl2 hypoxia-induced injury PC12 cells CoCl2 treatment upregulated 31264277 2970 Rat rno-miR-337-3p miRNA palmitate and palmitate plus oleate. insulin resistance (IR) mouse myoblasts palmitate and palmitate plus oleate treatment upregulated 21183973 2971 Rat rno-miR-337-5p miRNA artemisinin (ART) ventricular arrhythmias (VA) transverse aortic constriction (TAC) surgery treated rats left ventricle (LV) tissues artemisinin (ART) treatment upregulated 30595983 2972 Rat rno-miR-338 miRNA Tectorigenin cell proliferation rat pulmonary fibroblasts Tectorigenin treatment "Tectorigenin inhibits the proliferation of pulmonary fibroblasts in vitro and enhances miR-338* expression, which might in turn downregulate LPA1" 20600766 2973 Rat rno-miR-338 miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment downregulated 27041227 2974 Rat rno-miR-338 miRNA ¦Ä-opioid receptor (DOR) hypoxic/ischemic injury hearts ¦Ä-opioid receptor (DOR) activation treatment upregulated 27576463 2975 Rat rno-miR-338 miRNA oxygen lung injury pregnant rats lung tissue inspired oxygen of 10.5 or 24% for two days treatment downregulated 25120593 2976 Rat rno-miR-338 miRNA streptozocin (STZ) diabetic retinopathy (DR) ?retinas?tissues streptozotocin (STZ) treatment downregulated 22156553 2977 Rat rno-miR-338-3p miRNA particulate matter (PM2.5) allergic rhinitis (AR) nasal mucosa particulate matter 2.5 (PM2.5) treatment upregulated 32192351 2978 Rat rno-miR-338-3p miRNA particulate matter (PM2.5) allergic rhinitis (AR) nasal mucosa tissues fine particulate matter (PM2.5) exposure treatment The results showed that miR-338-3p was downregulated in both nasal mucosa of PM25-exacerbated AR rat models and PM25-treated RPMI-2650 cells 33770685 2979 Rat rno-miR-338-3p miRNA IL-6 skeletal muscle regeneration rat primary skeletal muscle cells (RSkMC) IL-6 treatment upregulated 31820147 2980 Rat rno-miR-338-3p miRNA IL-6 skeletal muscle regeneration rat primary skeletal muscle cells (RSkMC) IL-6 treatment upregulated 31820147 2981 Rat rno-miR-339 miRNA adenosine effect of acupuncture nerve growth factor-induced differentiated PC12 cells adenosine treatment downregulated 25199539 2982 Rat rno-miR-339-3p miRNA sevoflurane (SEV) neural function left cortex of the brain Sevoflurane treatment significantly increased 26021509 2983 Rat rno-miR-339-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 2984 Rat rno-miR-339-5p miRNA loureirin A follicle stem cell (HFSC) differentiation primary rat follicle stem cell (HFSC) loureirin A treatment downregulated 29901112 2985 Rat rno-miR-33a miRNA grape seed proanthocyanidins (GSPs) cardiovascular disease (CVD) healthy rats liver chronic (3 weeks) of grape seed proanthocyanidins (GSPE) treatment downregulated 24445039 2986 Rat rno-miR-33a miRNA cafeteria diet dyslipidemia liver of rat cafeteria diet feed upregulated 23922812 2987 Rat rno-miR-33a miRNA proanthocyanidins or docosahexaenoic acid dyslipidemia liver of rat proanthocyanidins or docosahexaenoic acid?treatment treatment downregulated 23922812 2988 Rat rno-miR-33a miRNA tanshinone IIA (Tan IIA) hyperlipidemia liver tissues Tanshinone IIA treatment downregulated 27082100 2989 Rat rno-miR-33a miRNA proanthocyanidin obesity livers of obese rats proanthocyanidin treatment 3 weeks of supplementation with grape seed proanthocyanidin extract normalized the overexpression of miR-33a and miR-122 in obese rats' liver for all doses studied 25769350 2990 Rat rno-miR-33a miRNA grape seed proanthocyandin extract (GSPE) obesity and metabolic syndrome rat hepatoma Fao cells grape seed proanthocyanidins extracts (GSPE) treatment "although GSPE reduced both miR-122 and miR-33a levels, GPE reduced miR-122 but upregulated miR-33a expression. The expression of miR-122 and miR-33a was not altered by the DF fraction in either Fao or HepG2 cells" 24165878 2991 Rat rno-miR-33a miRNA insulin-like growth factor 1 (IGF-1) post-stroke brain tissues Post-stroke ICV administration of IGF-1 to middle-aged female rats treatment downregulated 24618563 2992 Rat rno-miR-33a miRNA grape seed proanthocyanidins (GSPs) reduced postprandial lipemia rat liver tissues and lipid extraction grape seed proanthocyanidins (GSPE) treatment GSPE repressed miR-33a and miR-122 liver expression and reduced postprandial lipemia in a dose-dependent manner. 24445039 2993 Rat rno-miR-33a miRNA ghrelin type 2 diabetes mellitus (T2DM) diabetes rat liver tissues ghrelin treatment downregulated 31468622 2994 Rat rno-miR-33a miRNA streptozocin (STZ) type 2 diabetes mellitus (T2DM) rat liver tissues streptozotocin treatment upregulated 31468622 2995 Rat rno-miR-33a-3p miRNA "3,5-diiodo-L-thyronine (T2)" glucose homeostasis serum from high fat diet fed rats "3,5-diiodo-L-thyronine (T2) treatment" downregulated 31719576 2996 Rat rno-miR-33a-5p miRNA homocysteine (Hcy) cell damage primary cardiac microvascular endothelial cells (CMECs) homocysteine (HCY) treatment upregulated 30825202 2997 Rat rno-miR-33a-5p miRNA oxygen glucose deprivation (OGD) ischemic stroke (IS) brain microvascular endothelial cell (BMEC) oxygen glucose deprivation (OGD) treatment miR-33a-5p expression was the lowest at 4 h and the highest at 10 h after OGD treatment. 31986122 2998 Rat rno-miR-33b miRNA lovastatin medulloblastoma c-Myc-null rat fibroblast Rat1 cells (clone HO15.19) lovastatin? treatment upregulated 22887866 2999 Rat rno-miR-33e miRNA H2O2 oxidative stress cardiovascular cells NRVCs and RAVSMCs H2O2 treatment downregulated 24612558 3000 Rat rno-miR-34 miRNA dimethylnitrosamine (DMN) liver fibrosis rat hepatic fibrosis tissue dimethylnitrosamine (DMN) treatment upregulated 21366874 3001 Rat rno-miR-34 miRNA tamoxifen (TAM) hepatocellular carcinoma (HCC) rat liver tamoxifen? treatment upregulated 17343880 3002 Rat rno-miR-340-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3003 Rat rno-miR-340-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) acute ischemic stroke (AIS) PC-12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment The expression levels of miR-340-5p were decreased in PC12 cells following OGD/R induction. 32468054 3004 Rat rno-miR-340-5p miRNA sevoflurane (SEV) acute lung injury (ALI) lung tissues sevoflurane treatment downregulated 28617947 3005 Rat rno-miR-340-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) acute myocardial infarction (AMI) H9C2 cardiomyocytes oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 30989715 3006 Rat rno-miR-340-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia/reperfusion (I/R) injury rat hippocampal neurons oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 31870893 3007 Rat rno-miR-340-5p miRNA oxygen glucose deprivation (OGD) depression primary hippocampal neurons oxygen glucose deprivation (OGD) treatment miR-340-5p was poorly expressed in these neurons after OGDR stimulation. 31870893 3008 Rat rno-miR-340-5p miRNA collagenase VII intracerebral haemorrhage (ICH) brain tissues collagenase VII treatment downregulated 33176298 3009 Rat rno-miR-340-5p miRNA chronic constriction injury (CCI) neuropathic pain (NP) spinal cord tissues and isolated microglial cells chronic constriction injury (CCI) induce downregulated 30848438 3010 Rat rno-miR-341 miRNA huoxue jiedu formula (HXJDF) diabetic retinopathy (DR) retinal tissues HuoXue JieDu Formula (HXJDF) treatment miR-341 was downregulated in HuoXue JieDu Formula (HXJDF) treated group when compared with diabetic mice. 33271246 3011 Rat rno-miR-341 miRNA artemisinin (ART) ventricular arrhythmias (VA) transverse aortic constriction (TAC) surgery treated rats left ventricle (LV) tissues artemisinin (ART) treatment upregulated 30595983 3012 Rat rno-miR-342 miRNA caffeic acid diabetic nephropathy (DN) high-fat diet and streptozotocin-induced (HFD-STZ) diabetic rats caffeic acid (CA) treatment downregulated 28536471 3013 Rat rno-miR-342-5p miRNA cisplatin (DDP) nasopharyngeal carcinoma (NPC) HNE1cells; CNE2 cells cisplatin treatment LINC00346 regulates the cisplatin resistance of NPC cells by inhibiting miR-342-5p. 32397872 3014 Rat rno-miR-344b-1-3p miRNA aspergillus fumigatus (A. fumigatus) autophagy "A rat alveolar macrophage cell line, NR8383" aspergillus fumigatus infection downregulated 31258647 3015 Rat rno-miR-344b-1-3p miRNA smoking chronic obstructive pulmonary disease (COPD) rats alveolar macrophages (AMs) smoke inhalation treatment upregulated in alveolar macrophages (AMs) 28243080 3016 Rat rno-miR-344b-3p miRNA triptolide (TPL) nephropathy blood and renal tissues rats with adriamycin-induced nephropathy treatment triptolide treatment reversed the increase in the expression of these two miRNAs 26078766 3017 Rat rno-miR-345 miRNA quercetin oxidative stress PC-12 cells Quercetin treatment downregulated 33343808 3018 Rat rno-miR-346 miRNA H2O2 acute myocardial infarction (AMI) H9c2 cells H2O2 treatment MiR-346 was significantly upregulated in H2O2-treated H9c2 cells. 33275244 3019 Rat rno-miR-346-3p miRNA dexmedetomidine (DEX) myocardial ischemia/reperfusion (I/R) injury (MIRI) rat cardiomyocytes dexamethasone (DEX) treatment DEX promoted miR-346-3p expression in MI/R rats 33731281 3020 Rat rno-miR-347 miRNA hypoxia cortical injury rat cortex tisssues hypoxia treatment downregulated 23272113 3021 Rat rno-miR-347 miRNA light focal retinal degeneration right eye light treatment upregulated 25921151 3022 Rat rno-miR-3473 miRNA cisplatin and gentamicin drug-induced acute kidney injury (DIKI) plasma "cisplatin (CSP, 6?mg/kg) and gentamicin (GEN, 120?mg/kg) treatment" miR-3473 was specifically upregulated in the glomerular injury models. 30682439 3023 Rat rno-mir-3473 miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3024 Rat rno-miR-3473 miRNA Jianpi Xiaoke (JPXK) type 2 diabetes mellitus (T2DM) rat Jianpi Xiaoke (JPXK) treatment upregulated 33456489 3025 Rat rno-miR-34a miRNA betanin (BET) liver damage cisplatin (DDP)-induced liver injury rats liver tissues betanin (BET) treatment downregulated 33661552 3026 Rat rno-miR-34a miRNA cisplatin (DDP) liver damage liver tissues cisplatin treatment upregulated 33661552 3027 Rat rno-miR-34a miRNA sepsis acute kidney injury (AKI) ?kidney tissues cecal ligation puncture induced sepsis treatment MiR-34a level in kidney tissues was upregulated in the sepsis-induced AKI model 31081107 3028 Rat rno-miR-34a miRNA diclofenac (Diclo) acute kidney injury (AKI) kidney tissues diclofenac (Diclo) treatment Diclo administration caused a significant reduction of mitofusin-2 (Mfn2) and increase of microRNA-34a (miR-34a) mRNA expressions. 33165700 3029 Rat rno-miR-34a miRNA Thymoquinone (TQ) acute kidney injury (AKI) kidney tissues thymoquinone treatment downregulated 33165700 3030 Rat rno-miR-34a miRNA D-galactosamine (D-GalN) aging hippocampus D-gal treatment upregulated 27780933 3031 Rat rno-miR-34a miRNA alcohol alcoholic liver disease (ALD) liver tissues alcohol exposure upregulated 29873178 3032 Rat rno-miR-34a miRNA valproic acid (VPA) autism spectrum disorder (ASD) ASD rats cerebellar cortex and primary cerebellar cortical neuronal cells VPA treatment upregulated in cerebellar cortex and primary cerebellar cortical neuronal cells 28803955 3033 Rat rno-miR-34a miRNA low temperature breast cancer neural stem cells (NSCs) low temperatures treatment downregulated 23354401 3034 Rat rno-miR-34a miRNA comfrey tumorigenesis rat liver comfrey treatment upragulated 21370286 3035 Rat rno-miR-34a miRNA doxorubicin (DOX) cardiac injury cardiac cells doxorubicin (DOXO) treatment upregulated 27694688 3036 Rat rno-miR-34a miRNA hydrogen sulfide (H2S) cardiac fibrosis thyroxine-induced rats myocardial tissues Hydrogen sulfide (H2S) treatment downregulated 29743447 3037 Rat rno-miR-34a miRNA TGF-¦Â1 cardiac fibrosis primary rat cardiac fibroblasts TGF-¦Â1 treatment upregulated 29551367 3038 Rat rno-miR-34a miRNA thyroxine cardiac fibrosis myocardial tissues thyroxine treatment upregulated 29743447 3039 Rat rno-miR-34a miRNA angiotensin II (Ang II) cardiac hypertrophy rat cardiomyocytes angiotensin II (Ang II) treatment downregulated 24728149 3040 Rat rno-miR-34a miRNA high glucose (HG) cardiomyocyte apoptosis H9c2 tissues High Glucose treatment miR-34a contributes to high glucose-induced decreases in Bcl-2 expression and subsequent cardiomyocyte apoptosis 24339958 3041 Rat rno-miR-34a miRNA paraquat (PQ) apoptosis PC 12 cells paraquat (PQ) treatment upregulated 25174400 3042 Rat rno-miR-34a miRNA X-rays cell cycle arrest rats X-ray exposure treatment upregulated 25594002 3043 Rat rno-miR-34a miRNA high-salt/low-potassium diet cerebral and renal vascular injuries stroke-prone spontaneously hypertensive rats high-salt/low-potassium diet treatment downregulated 23297375 3044 Rat rno-miR-34a miRNA typhae pollen polysaccharides (TPP) cerebral ischemia injury (CII) PC12 cells typhae pollen polysaccharides (TPP) treatment TPP downregulated miR-34a expression 32635836 3045 Rat rno-miR-34a miRNA furan cholangiocarcinoma and hepatocellular tumors liver furan treatment upregulated 26194646 3046 Rat rno-miR-34a miRNA "2,4,6-trinitrobenzene sulfonic acid (TNBS)" chronic inflammatory visceral pain (CIVP) spinal cord tissues of rats "2,4,6-Trinitrobenzenesulfonic acid (TNBS) treatment" downregulated 31324142 3047 Rat rno-miR-34a miRNA dexmedetomidine (DEX) chronic inflammatory visceral pain (CIVP) spinal cord tissues of (TNBS)-induced chronic inflammatory visceral pain (CIVP) rats dexamethasone (DEX) treatment upregulated 31324142 3048 Rat rno-miR-34a miRNA cisplatin (DDP) cisplatin (DDP)-induced nephrotoxicity renal tissue homogenate cisplatin treatment upregulated 32777238 3049 Rat rno-miR-34a miRNA pentoxifylline (PTX) cisplatin (DDP)-induced nephrotoxicity renal tissue homogenate pentoxifylline (PTX) treatment downregulated 32777238 3050 Rat rno-miR-34a miRNA urolithin A (UA) cognitive impairment H2O2-induced PC12 cell ?urolithin A treatment downregulated 31420820 3051 Rat rno-miR-34a miRNA azoxymethane (AOM) colorectal cancer (CRC) rat colon Epithelial cells azoxymethane (AOM) treatment "Of the 27 miRNAs expressed at higher (P < 0.05) levels in tumors, miR-34a, 132, 223 and 224 were overexpressed at >10-fold. In contrast, the expression levels of miR-192, 194, 215 and 375 were dramatically reduced (?0.32-fold) in adenocarcinomas." 19825969 3052 Rat rno-miR-34a miRNA fish oil and pectin colorectal cancer (CRC) colon tissue of rats corn oil ¡À fish oil with pectin ¡À cellulose upregulated 21406606 3053 Rat rno-miR-34a miRNA palmitate diabetes mellitus (DM) INS-1 cells palmitate (Pal) treatment upregulated 30131392 3054 Rat rno-miR-34a miRNA astragaloside IV (AS-IV) diabetic cardiomyopathy (DCM) High glucose (HG)-treated rat cardiomyocytes (H9C2(2-1)) astragaloside IV (AS-IV) treatment downregulated 31713440 3055 Rat rno-miR-34a miRNA granulocyte-colony stimulating factor (G-CSF) diabetic cardiomyopathy (DCM) H9c2 cells Granulocyte colony-stimulating factor?treatment G-CSF treatment significantly decreased apoptosis and reduced miR-34a expression in diabetic myocardium and H9c2 cells under the HG condition. 31237127 3056 Rat rno-miR-34a miRNA granulocyte-colony stimulating factor (G-CSF) diabetic cardiomyopathy (DCM) high glucose (HG)-induced H9c2 cells Granulocyte colony-stimulating factor?treatment downregulated 31237127 3057 Rat rno-miR-34a miRNA high glucose (HG) diabetic cardiomyopathy (DCM) H9c2 cells ?high glucose (HG) induce HOTAIR protected against DCM via activation of the SIRT1 expression by sponging miR-34a. 30216438 3058 Rat rno-miR-34a miRNA high glucose (HG) diabetic cardiomyopathy (DCM) rat cardiomyocytes (H9C2(2-1)) high glucose (HG) treatment upregulated 31713440 3059 Rat rno-miR-34a miRNA high glucose (HG) diabetic cardiomyopathy (DCM) H9c2 cells high glucose treatment OIP5-AS1 overexpression promotes viability and inhibits high glucose-induced oxidative stress of cardiomyocytes by targeting microRNA-34a/SIRT1 axis in diabetic cardiomyopathy. 33380310 3060 Rat rno-miR-34a miRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) Wistar rats left ventricle (LV) STZ treatment upregulated 28199183 3061 Rat rno-miR-34a miRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) heart tissues streptozotocin (STZ) treatment miR-34a was upregulated in the diabetic hearts 30216438 3062 Rat rno-miR-34a miRNA high glucose (HG) diabetic retinopathy (DR) Rat retinal vascular endothelial cells (RVECs) high glucose (HG) treatment MicroRNA-34a promotes apoptosis of retinal vascular endothelial cells by targeting SIRT1 in rats with diabetic retinopathy. 31863767 3063 Rat rno-miR-34a miRNA mitomycin C-polylactic acid ( MMC-PLA) film epidural scar hyperplasia and adhesion post-laminectomy rat scar tissues 25 mg of PLA film containing 0.01% MMC was implanted on the laminectomy area upregulated 28617531 3064 Rat rno-miR-34a miRNA magnesium (Mg2+ ) epilepsy rat hippocampal neuronal cells "To induce the hippocampal neuronal spontaneous recurrent epileptiform discharges (SREDs) pattern, the neuronal cultures had been treated with a solution containing no added MgCl2 (Mg2+-free) for 3?h on the 14th day" SREDs Induces Increase of?miR-34a Expression and?Decrease of?Notch Pathway Expression 30877521 3065 Rat rno-miR-34a miRNA pterostilbene fructose-induced hepatic lipid accumulation BRL-3A cells Pterostilbene treatment Pterostilbene recovered the fructose-disturbed miR-34a expression 31927917 3066 Rat rno-miR-34a miRNA N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) gastric cancer (GC) rat gastric tissue N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) treatment downregulated 31648165 3067 Rat rno-miR-34a miRNA Weipixiao (WPX) decoction gastric cancer (GC) N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) treated rat gastric tissue N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) treatment upregulated 31648165 3068 Rat rno-miR-34a miRNA aristolochic acid genotoxic and carcinogenic tissues from transgenic Big Blue rats liver and kidney aristolochic acid (AA) treatment "dysregulated in the kidney, miR-34a was dysregulated in the liver" 25106556 3069 Rat rno-miR-34a miRNA chromium (Cr) hepatic ischemia/reperfusion injury (HIRI) serum Cr treatment downregulated 28963950 3070 Rat rno-miR-34a miRNA zinc sulfate (ZnSO4) hepatic ischemia/reperfusion injury (HIRI) ischemia-reperfusion (IR) injuried rats liver tissues zinc sulfate (ZnSO4) treatment downregulated 30014282 3071 Rat rno-miR-34a miRNA zinc sulfate (ZnSO4) hepatic ischemia/reperfusion injury (HIRI) ischemia-reperfusion (IR) rats serum zinc sulfate (ZnSO4) treatment downregulated 30014282 3072 Rat rno-miR-34a miRNA zinc sulfate (ZnSO4) hepatic ischemia/reperfusion injury (HIRI) serum ZnSO4 treatment downregulated 28963950 3073 Rat rno-miR-34a miRNA methyl-deficient diet hepatocellular carcinoma (HCC) liver tissues methyl-deficient diet feed downregulated 18942116 3074 Rat rno-miR-34a miRNA ¦Â-ionone (¦ÂI) hepatocellular carcinoma (HCC) rats hepatocyte ¦ÂI (16 mg/100 g body weight) treatment "upregulated(miR-122 , miR-34a) ;downregulated (miR-181b , miR-708)" 27061051 3075 Rat rno-miR-34a miRNA furan hepatotoxicity liver Furan treatment upregulated 27371368 3076 Rat rno-miR-34a miRNA streptozocin (STZ) hyperglycemia-induced vascular endothelial cell damage thoracic aorta tissues streptozotocin (STZ) treatment upregulated 29529692 3077 Rat rno-miR-34a miRNA clamping both renal arteries ischemia/reperfusion (I/R) injury male rats clamping both renal arteries for 45 min upregulated 28129785 3078 Rat rno-miR-34a miRNA ischemia/reperfusion (I/R) ischemia/reperfusion (I/R) injury cardiomyocytes (NRCMs) ischemia/reperfusion (I/R) treatment upregulated 28599575 3079 Rat rno-miR-34a miRNA hypoxia ischemic injury cardiomyocytes of 1-3 day-old male Wistar rats long-term (4 h) exposure to hypoxia followed by 6 h of reoxygenation upregulated 28709867 3080 Rat rno-miR-34a miRNA hypoxia ischemic injury cardiomyocytes hypoxia treatment upregulated 28709867 3081 Rat rno-miR-34a miRNA TGF-¦Â1 kidney fibrosis rat renal fibroblast cell line (NRK-49F) TGF-¦Â1-ed fibroblasts treatment miR-34a is markedly upregulated in microvesicles isolated from the cell culture medium 25107369 3082 Rat rno-miR-34a miRNA fructose liver fibrosis rats liver tissues and BRL-3A cells fructose treatment upregulated 30632134 3083 Rat rno-miR-34a miRNA Pterostilbene liver fibrosis fructose-treated rats liver tissues and BRL-3A cells Pterostilbene treatment downregulated 30632134 3084 Rat rno-miR-34a miRNA estradiol metabolic effects of estrogen liver tissues estradiol treatment downregulated 32045601 3085 Rat rno-miR-34a miRNA deoxycholic acid (DCA) apoptosis primary rat hepatocytes deoxycholic acid (DCA) treatment upregulated 24421392 3086 Rat rno-miR-34a miRNA resveratrol cardiac fibrosis cardiac fibroblasts (CFs) resveratrol (Res) treatment Resveratrol decreased the levels of miR-34ain TGF- ¦Â1-treated CFs 30648109 3087 Rat rno-miR-34a miRNA oxygen glucose deprivation (OGD) myocardial infarction (MI) rat H9c2 cells oxygen glucose deprivation (OGD) treatment circDENND2A negatively regulated miR-34a miR-34a overexpression weakened the protective effects of circDENND2A in OGD-injury 31878833 3088 Rat rno-miR-34a miRNA oxygen glucose deprivation (OGD) myocardial infarction (MI) H9c2 cells oxygen glucose deprivation (OGD) treatment circDENND2A overexpression enhanced OGD-inhibited cell viability and migration but declined OGD-promoted apoptosis by downregulating miR-34a and via ¦Â-catenin and Ras/Raf/MEK/ERK pathways 31878833 3089 Rat rno-miR-34a miRNA silymarin (Sm) myocardial infarction (MI) heart sissues Silymarin (SM) treatment miRNA-34a was downregulated in SM-treated rats 31974855 3090 Rat rno-miR-34a miRNA isoproterenol myocardial injury heart tissues isoproterenol (ISO) treatment upregulated 31794687 3091 Rat rno-miR-34a miRNA resveratrol myocardial injury isoproterenol-induced rat heart tissues resveratrol (RS) treatment downregulated 31794687 3092 Rat rno-miR-34a miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells 1%O upregulated 28894025 3093 Rat rno-miR-34a miRNA luteolin neuritogenesis PC12 cells Luteolin treatment upregulated 25865700 3094 Rat rno-miR-34a miRNA nerve growth factor (NGF) neuronal differentiation differentiating PC12 cells nerve growth factor (NGF) treatment upregulated 28084588 3095 Rat rno-miR-34a miRNA lidocaine neurotoxicity dorsal root ganglia neurons (DRGNs) lidocaine treatment downregulated 26455477 3096 Rat rno-miR-34a miRNA fish oil nonalcoholic fatty liver disease (NAFLD) high-fat high-cholesterol diet rats supplemented with fish oil (FOH) dysregulated 28691019 3097 Rat rno-miR-34a miRNA "quinacrine, erythromycin and tetracycline" non-surgical sterilization Wistar albino 12-14 week old female rats "quinacrine, erythromycin , tetracycline treatment" upregulated 25195052 3098 Rat rno-miR-34a miRNA "3,6-dihydroxyflavone (3,6-DHF)" obesity breast?of rats "3,6-dihydroxyflavone (3,6-DHF) treatment" "the global upregulation of miR-21 and downregulated of miR-34a in breast carcinogenesis could be reversed by 3,6-DHF" 22616882 3099 Rat rno-miR-34a miRNA IL-1¦Â osteoarthritis (OA) rat Articular chondrocytes IL-1¦Â treatment Silencing of miR-34a by LNA-modified anti-sense could effectively reduce rat chondrocyte apoptosis induced by IL-1¦Â 20675358 3100 Rat rno-miR-34a miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 3101 Rat rno-miR-34a miRNA oxygen oxygen-induced retinopathy (OIR) retinas tissues oxygen induce treatment downregulated 30571142 3102 Rat rno-miR-34a miRNA rotenone (ROT) parkinson's disease (PD) striatum of parkinsonian rats rotenone exposure treatment upregulated 30267378 3103 Rat rno-miR-34a miRNA 1-methyl-4-phenylpyridinium (MPP+) parkinson's disease (PD) PC12 cells N-methyl-4-phenylpyridinium (MPP +) treatment "MPP+ toxicity significantly caused upregulated in miR-34a, miR-141, and miR-9." 29631008 3104 Rat rno-miR-34a miRNA single dose irradiation radiation-induced lung injury (RILI) male Wistar rats lung tissues subjected to single dose irradiation with 20 Gy using 6 MV x-rays to the right lung treatment upregulated 24886372 3105 Rat rno-miR-34a miRNA dioscin renal injury cisplatin (CDDP)-induced rats nephrotoxicity dioscin treatment downregulated 28514495 3106 Rat rno-miR-34a miRNA TGF-¦Â1 renal interstitial fibrosis (RIF) Rat proximal tubular epithelial cell line (NRK-52E) secreted microvesicles (MVs) TGF-¦Â1 treatment upregulated 30867715 3107 Rat rno-miR-34a miRNA diclofenac (Diclo) renal oxidative damage kidney tissues diclofenac (Diclo) treatment Diclo administration caused a significant reduction of mitofusin-2 (Mfn2) and increase of microRNA-34a (miR-34a) mRNA expressions. 33165700 3108 Rat rno-miR-34a miRNA oxygen retinal angiogenesis retina of oxygen-induced retinopathy rats oxygen induce treatment downregulated 30571142 3109 Rat rno-miR-34a miRNA lipopolysaccharide (LPS) sepsis plasma and renal tissue lipopolysaccharide (LPS) treatment upregulated 29663998 3110 Rat rno-miR-34a miRNA lipopolysaccharide (LPS) sepsis pulmonary macrophages lipopolysaccharide (LPS) treatment miR-34a was upregulated in Lipopolysaccharide (LPS)-induced pulmonary macrophages. 30021364 3111 Rat rno-miR-34a miRNA allen's weight-drop method spinal cord injury (SCI) spinal neuron allen's weight-drop method treatment downregulated 31490756 3112 Rat rno-miR-34a miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment upregulated 21094214 3113 Rat rno-miR-34a miRNA "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine)" teratogenesis mouse and rat limb buds "5-Aza-2'-deoxycytidine (5-Aza-dC, decitabine) treatment" miR-34 family members are the most upregulated miRNAs 24623309 3114 Rat rno-miR-34a miRNA cyclosporine A (CsA) testicular damage testis cyclosporine A (CsA) treatment Exposure to CsA increased the expression of mir-34a. 32569592 3115 Rat rno-miR-34a miRNA high glucose and palmitate (HG/PA) type 2 diabetes mellitus (T2DM) INS-1 cells high glucose and palmitate (HG/PA) treatment upregulated 31737170 3116 Rat rno-miR-34a miRNA metformin (Met) type 2 diabetes mellitus (T2DM) brain tissues "orally and daily administrated 2.0 ml NSO, 100 mg metformin (MT)" downregulated in the brain 28505155 3117 Rat rno-miR-34a miRNA coxsackievirus B3 (CVB3) viral myocarditis (VM) rat primary cultured cardiomyocytes Coxsackievirus B3 (CVB3) infection upregulated 30968966 3118 Rat rno-miR-34a-3p miRNA sevoflurane (SEV) acute lung injury (ALI) lung tissues Sevoflurane (Sev) treatment "sevoflurane reduces inflammatory factor expression, increases lung cell viability and inhibits lung cell apoptosis in ALI through upregulation of miR-34a-3p" 32147387 3119 Rat rno-miR-34a-3p miRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) serum monocrotaline (MCT) treatment downregulated 29431643 3120 Rat rno-miR-34a-5p miRNA cadmium (Cd) cadmium (Cd)-induced kidney injury renal cortex cadmium (Cd) treatment upregulated 29543730 3121 Rat rno-miR-34a-5p miRNA doxorubicin (DOX) cardiotoxicity rat cardiomyocyte H9c2 cells doxorubicin treatment upregulated 28928469 3122 Rat rno-miR-34a-5p miRNA liraglutide endothelial dysfunction aortic endothelial in diabetic rats liraglutide treatment downregulated 30863684 3123 Rat rno-miR-34a-5p miRNA aflatoxin B1 (AFB1) hepatocellular carcinoma (HCC) F344 rats liver tissues aflatoxin B1 (AFB4) treatment upregulated 28218475 3124 Rat rno-miR-34a-5p miRNA sorafenib (SOR) hepatocellular carcinoma (HCC) pulmonary metastatic tissue sorafenib treatment upregulated 26026584 3125 Rat rno-miR-34a-5p miRNA aflatoxin B1 (AFB1) hepatotoxicant and genotoxicant liver aflatoxin B1 (AFB1) treatment upregulated 26385312 3126 Rat rno-miR-34a-5p miRNA sevoflurane (SEV) hypoxia-induced injury H9c2 cells sevoflurane treatment downregulated 29554593 3127 Rat rno-miR-34a-5p miRNA hypoxia hypoxic/ischemic injury Male Sprague Dawley rats "were exposed to hypoxia (9.5-10% O2) for 1, 5, or 10 days" downregulated 29262398 3128 Rat rno-miR-34a-5p miRNA thioacetamide (TAA) liver toxicity Sprague-Dawley rats livers "treat with TAA at three doses (4.5, 15 and 45 mg/kg) and four time points (3-, 7-, 14- and 28-days) treatment" dysregulatedin livers 28596526 3129 Rat rno-miR-34a-5p miRNA N-methyl-D-aspartate receptor long-term potentiation (LTP) persistence rat dentate gyrus rat dentate gyrus 20 min post-LTP induction in vivo treatment downregulated 25538559 3130 Rat rno-miR-34a-5p miRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia induce upregulated 30312158 3131 Rat rno-miR-34a-5p miRNA high fat diet (HFD) nonalcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD) feed upregulated 31915454 3132 Rat rno-miR-34a-5p miRNA Shenling Baizhu San (SLBZS) nonalcoholic fatty liver disease (NAFLD) liver tissues Shenling Baizhu San (SLBZS) treatment the expression levels were reversed by SLBZS administration 31915454 3133 Rat rno-miR-34a-5p miRNA H2O2 spinal cord injury (SCI) rat PC-12 cells H2O2 treatment miR-34a-5p was confirmed as a target of PEG10 and miR-34a-5p inhibitor remitted PEG10-induced H2O2-injury. 31835090 3134 Rat rno-miR-34a-5p miRNA H2O2 spinal cord injury (SCI) PC-12 cells H2O2 treatment Knockdown PEG10 remitted H2O2-injury of PC-12 cells by targeting miR-34a-5p/TLX. 31835090 3135 Rat rno-miR-34b miRNA H2O2 cerebral ischemia/reperfusion (I/R) injury rat neuroblast B35 cells H2O2 treatment downregulated 30539753 3136 Rat rno-miR-34b miRNA nitrate fertility parameters testicular Nitrate treatment Nitrate administration in the DN group also decreased miR-34b. 32129362 3137 Rat rno-miR-34b miRNA H2O2 ischemic stroke (IS) rat neuroblast B35 cells H2O2 treatment downregulated 30539753 3138 Rat rno-miR-34b miRNA hypoxia ischemic stroke (IS) brain tissue Middle cerebral artery occlusion (MCAO) treatment downregulated 30539753 3139 Rat rno-miR-34b miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) neonatal rat ventricular cardiomyocytes hypoxia induce upregulated 31220137 3140 Rat rno-miR-34b miRNA lead (Pb) nervous system diseases rats hippocampus chronic lead exposure treatment upregulated 24960059 3141 Rat rno-miR-34b-3p miRNA rapamycin cardiac fibrosis heart tissues rapamycin (Rap) treatment upregulated 30647817 3142 Rat rno-miR-34b-3p miRNA steroids osteonecrosis bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 26459755 3143 Rat rno-miR-34b-3p miRNA smoking smoke inhalation injury (SII) bronchoalveolar lavage fluid (BALF) Smoke inhalation treatment upregulated 30139538 3144 Rat rno-miR-34b-5p miRNA guarana adipogenesis 3T3L1 cells guarana downregulated 28632199 3145 Rat rno-miR-34b-5p miRNA flurothyl brain injury hippocampus flurothyl treatment upregulated 27514646 3146 Rat rno-miR-34b-5p miRNA fluorine combined with aluminum (FA) fluorine combined with aluminum (FA)-induced developmental neurotoxicity hippocampi fluorine combined with aluminum (FA) treatment upregulated 30033483 3147 Rat rno-miR-34b-5p miRNA fluorine combined with aluminum (FA) neurotoxicity hippocampi in the offspring of rats fluorine combined with aluminum (FA) exposure upregulated 30033483 3148 Rat rno-miR-34b-5p miRNA 6-hydroxydopamine (6-OHDA) parkinson's disease (PD) substantia nigra 6-hydroxydopamine (6-OHDA) treatment downregulated of lncRNA BACE1-AS inhibits iNOS activation in the substantial nigra and improve oxidative stress injury in PD rats by upregulating miR-34b-5p and downregulating BACE1. 32308102 3149 Rat rno-miR-34b-5p miRNA letrozole polycystic ovarian syndrome (PCOS) Ovary?tissues letrozole treatment dysregulated 26745201 3150 Rat rno-miR-34c miRNA doxorubicin (DOX) cardiac injury ?rat heart doxorubicin treatment upregulated 22859947 3151 Rat rno-miR-34c miRNA blueberry breast cancer estrogen-mediated rats breast cancer blueberry-supplemented diet treatment upregulated 24245576 3152 Rat rno-miR-34c miRNA high glucose (HG) diabetic nephropathy (DN) rat glomerular mesangial cell line (HBZY-1) high glucose (HG) treatment downregulated 32721950 3153 Rat rno-miR-34c miRNA pentylenetetrazol (PTZ) epilepsy brain tissues pentylenetetrazol (PTZ) treatment upregulated 29344671 3154 Rat rno-miR-34c miRNA lead (Pb) nervous system diseases rats hippocampus chronic lead exposure treatment upregulated 24960059 3155 Rat rno-miR-34c miRNA lidocaine neurotoxicity dorsal root ganglia neurons (DRGNs) lidocaine treatment downregulated 26455477 3156 Rat rno-miR-34c miRNA catheter injury pathologic cardiovascular carotid artery catheter injury treatment upregulated 25683915 3157 Rat rno-miR-34c-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia/reperfusion (I/R) injury primary cortical neurons oxygen-glucose deprivation and reoxygenation (OGD/R) treatment the expression levels of miR-34c-5p were significantly reduced in MCAO rats and OGD/RP cells 33842985 3158 Rat rno-miR-34c-5p miRNA cigarette smoke (CS) chronic obstructive pulmonary disease (COPD) lung tissues cigarette smoke exposure downregulated 31032652 3159 Rat rno-miR-34c-5p miRNA streptozocin (STZ) diabetic retinopathy (DR) rat retinal streptozotocin (STZ)-induced diabetic rat treatment differential expressions 24502381 3160 Rat rno-miR-34c-5p miRNA "3,5-diiodo-L-thyronine (T2)" glucose homeostasis serum from high fat diet fed rats "3,5-diiodo-L-thyronine (T2) treatment" downregulated 31719576 3161 Rat rno-miR-34c-5p miRNA H2O2 hyperoxia-induced acute lung injury (HALI) rat type II alveolar epithelial cells (AECII) hydrogen peroxide (H2O2) treatment downregulated 29436647 3162 Rat rno-miR-34c-5p miRNA hypoxia hypoxic/ischemic injury Male Sprague Dawley rats "were exposed to hypoxia (9.5-10% O2) for 1, 5, or 10 days" upregulated 29262398 3163 Rat rno-miR-34c-5p miRNA steroids osteonecrosis bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 26459755 3164 Rat rno-miR-34c-5p miRNA smoking smoke inhalation injury (SII) bronchoalveolar lavage fluid (BALF) Smoke inhalation treatment upregulated 30139538 3165 Rat rno-miR-350 miRNA insert a cannula connected with a saline container into the anterior chamber acute ocular hypertension (AOH) adult albino rats retinal ganglion cells (RGCs) and microglial cells insert a cannula connected with a saline container into the anterior chamber upregulated 27535721 3166 Rat rno-miR-350 miRNA triiodo-l-thyronine (T3) liver fibrosis cardiomyocytes triiodothyronine (T?) treatment upregulated 22525353 3167 Rat rno-miR-351 miRNA light focal retinal degeneration right eye light treatment upregulated 25921151 3168 Rat rno-miR-351-5p miRNA dioscin intestinal ischemia/reperfusion (I/R) injury hypoxia-induced IEC-6 cells dioscin treatment downregulated 30503840 3169 Rat rno-miR-351-5p miRNA hypoxia intestinal ischemia/reperfusion (I/R) injury IEC-6 cells hypoxia induce upregulated 30503840 3170 Rat rno-miR-351-5p miRNA dioscin intestinal ischemia/reperfusion (I/R) injury hypoxia-induced IEC-6 cells dioscin treatment downregulated 30240824 3171 Rat rno-miR-351-5p miRNA hypoxia intestinal ischemia/reperfusion (I/R) injury IEC-6 cells hypoxia induce upregulated 30240824 3172 Rat rno-mir-351-5p miRNA glucocorticoid (GC) respiratory distress syndrome lung Glucocorticoids treatment downregulated 26997989 3173 Rat rno-miR-351-5p miRNA herb-partitioned moxibustion ulcerative colitis (UC) UC rats colon tissues herb-partitioned moxibustion upregulated 28246536 3174 Rat rno-miR-352 miRNA elevated fluid shear stress (FSS) improved collateral circulation rat hind limbs elevated fluid shear stress (FSS) downregulated 28751690 3175 Rat rno-miR-352 miRNA doxorubicin (DOX) ischemia/reperfusion (I/R) injury rats cardiomyocytes doxorubicin treatment upregulated 27919821 3176 Rat rno-miR-352 miRNA pilocarpine mesial temporal lobe epilepsy (MTLE) hippocampi pilocarpine treatment upregulated 27695061 3177 Rat rno-miR-3541 miRNA alcohol brain damage due to chronic heavy alcohol hippocampal tissues chronic alcohol administration upregulated 33228793 3178 Rat rno-miR-3544 miRNA grape seed procyanidin extract (GSPE) pancreatic islet injury rat islets grape seed procyanidin extract (GSPE)treatment "GSPE altered significantly the expression of miR-1249, miR-483, miR-30c-1*, and miR-3544." 23215023 3179 Rat rno-mir-3548 miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3180 Rat rno-miR-3552 miRNA hypoxia stroke middle cerebral artery occlusion (MCAO) Sprague-Dawley rat middle cerebral artery occlusion (MCAO) treatment upregulated 29113076 3181 Rat rno-miR-3557 miRNA aerobic exercise parkinson's disease (PD) brain tissues aerobic exercise training (AET) treatment upregulated 31309116 3182 Rat rno-miR-3557-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3183 Rat rno-miR-3559-5p miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment downregulated 27041227 3184 Rat rno-miR-3559-5p miRNA herb-partitioned moxibustion ulcerative colitis (UC) UC rats colon tissues herb-partitioned moxibustion upregulated 28246536 3185 Rat rno-miR-3562 miRNA huoxue jiedu formula (HXJDF) diabetic retinopathy (DR) retinal tissues HuoXue JieDu Formula (HXJDF) treatment miR-3562 was downregulated in HuoXue JieDu Formula (HXJDF) treated group when compared with diabetic mice. 33271246 3186 Rat rno-miR-3573-5p miRNA chronic unpredictable mild stress (CUMS) depression hippocampus tissues chronic unpredictable mild stressed (CUMS) treatment upregulated 28083819 3187 Rat rno-miR-3573-5p miRNA hronic unpredictable mild stressed (CUMS) depression rats hippocampal tissues stimulated daily with randomly applied mild stressors from among 14 different mild stressors upregulated 28083819 3188 Rat rno-miR-3574 miRNA intermittent hypoxia (IH) cardiac injury H9C2 cells intermittent hypoxia (IH) treatment "We confirmed that IH inhibited cell viability, induced cell apoptosis and suppressed miR-3574 expression in the H9c2." 33582657 3189 Rat rno-mir-3574 miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3190 Rat rno-miR-3578 miRNA Smad3 inhibitor (SIS3) intrauterine adhesion (IUA) endometrial stromal cells (ESCs) Smad3 inhibitor (SIS3) treatment upregulated 32447720 3191 Rat rno-mir-3578 miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3192 Rat rno-miR-3583-3p miRNA high fat diet (HFD) cardiac remodeling heart tissues high fat diet (HFD) feed upregulated 29884823 3193 Rat rno-miR-3583-3p miRNA propofol (PPF) neurotoxicity primary cultured neural stem cells (NSCs) propofol treatment downregulated 29679758 3194 Rat rno-miR-3584-5p miRNA propofol (PPF) neural function left cortex of the brain Propofol treatment significantly increased 26021509 3195 Rat rno-miR-3584-5p miRNA mono-n-butyl phthalate (MBP) precocious puberty and testicular tumors testicular Sertoli cells (SCs) mono-n-butyl phthalate (MBP) treatment upregulated 29162477 3196 Rat rno-miR-3584-5p miRNA mono-n-butyl phthalate (MBP) cell proliferation rat juvenile Sertoli cells (SCs) treat with 0.1mM MBP upregulated 29162477 3197 Rat rno-miR-3586-3p miRNA Smad3 inhibitor (SIS3) intrauterine adhesion (IUA) endometrial stromal cells (ESCs) Smad3 inhibitor (SIS3) treatment downregulated 32447720 3198 Rat rno-miR-3588 miRNA huoxue jiedu formula (HXJDF) diabetic retinopathy (DR) retinal tissues HuoXue JieDu Formula (HXJDF) treatment miR-3588 was downregulated in HuoXue JieDu Formula (HXJDF) treated group when compared with diabetic mice. 33271246 3199 Rat rno-miR-3588 miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment upregulated 27041227 3200 Rat rno-miR-3588 miRNA ochratoxin A (OTA) ochratoxin A (OTA) nephrotoxicity kidney?tissues OTA nephrotoxicity treatment suppressed in mid dose but then elevated in high dose 24885635 3201 Rat rno-miR-3590-3p miRNA bleomycin (BLM) lung fibrosis lung tissues bleomycin (BLM) treatment upregulated 33193637 3202 Rat rno-mir-3591 miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3203 Rat rno-miR-3595 miRNA baicalin (BAI) liver fibrosis platelet-derived growth factor-BB-treated HSC-T6 cells baicalin (BAI) treatment upregulated 29393361 3204 Rat rno-miR-3595 miRNA platelet derived growth factor-BB (PDGF-BB) liver fibrosis HSC-T6 cells platelet-derived growth factor-BB treatment downregulated 29393361 3205 Rat rno-miR-3596b miRNA herb-partitioned moxibustion ulcerative colitis (UC) UC rats colon tissues herb-partitioned moxibustion upregulated 28246536 3206 Rat rno-miR-361 miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia/reperfusion (I/R) injury PC12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment Protective Role of Astrocyte-Derived Exosomal microRNA-361 in Cerebral Ischemic-Reperfusion Injury by Regulating the AMPK/mTOR Signaling Pathway and Targeting CTSB 32801720 3207 Rat rno-miR-361 miRNA palmitate and palmitate plus oleate. insulin resistance (IR) mouse myoblasts palmitate and palmitate plus oleate treatment upregulated 21183973 3208 Rat rno-miR-361 miRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment downregulated 30373531 3209 Rat rno-miR-361-5p miRNA dexmedetomidine (DEX) osteoporosis human umbilical vein endothelial cells (HUVECs) dexamethasone (DEX) treatment "After Dex treatment, the expressions of miR-361-5p, VEGFA, BMD related indexes were increased in OP rats." 33631172 3210 Rat rno-miR-362* miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment downregulated 27041227 3211 Rat rno-miR-362-3p miRNA palmitate diabetes mellitus (DM) INS-1 cells palmitate (Pal) treatment downregulated 30131392 3212 Rat rno-miR-362-3p miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC-12 cells lipopolysaccharide (LPS) treatment "SNHG1 regulated cell viability, apoptosis and autophagy in LPS-treated PC12 cells" 33515352 3213 Rat rno-miR-362-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3214 Rat rno-miR-363 miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment upregulated 27041227 3215 Rat rno-miR-363 miRNA hypoxia myocardial infarction (MI) rat myocardium-derived H9C2 and 293T cells 1% O2 at 37 _x0002_C for 24 h upregulated 28402919 3216 Rat rno-miR-363 miRNA streptozocin (STZ) type 2 diabetes mellitus (T2DM) Bladder Detrusor Tissues streptozocin (STZ) treatment miR-363 is Downregulated in STZ-Induced T2DM. 33294298 3217 Rat rno-miR-365 miRNA dexamethasone (DEX) cartilage injury articular cartilage dexamethasone (DEX) treatment miR-365 was downregulated compared with control group. 29207029 3218 Rat rno-miR-365 miRNA cyclic mechanical stretch (CMS) cell differentiation bone marrow-derived mesenchymal stem cells (BMSCs) Cyclic tensile strain (CTS) treatment upregulated 31276691 3219 Rat rno-miR-365 miRNA streptozocin (STZ) diabetic retinopathy (DR) retina tissues streptozotocin (STZ) treatment upregulated 29196060 3220 Rat rno-miR-365 miRNA H2O2 ischemic neuroinflammatory injury primary cultured neurons H2O2 treatment upregulated 30977043 3221 Rat rno-miR-365 miRNA morphine morphine tolerance neurons of the spinal cord rats treatment treatment downregulated 27922111 3222 Rat rno-miR-365 miRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment upregulated 30373531 3223 Rat rno-miR-3657 miRNA apatinib advanced gastric cancers (AGCs) BGC-823 and HGC-27 apatinib treatment Silencing of circRACGAP1 sensitizes gastric cancer cells to apatinib via modulating autophagy by targeting miR-3657 and ATG7 32139670 3224 Rat rno-miR-367 miRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment upregulated 31845077 3225 Rat rno-miR-367 miRNA doxorubicin (DOX) cardiac injury ?rat heart doxorubicin treatment upregulated 22859947 3226 Rat rno-miR-369 miRNA hypoxia myocardial infarction (MI) rat myocardial tissues hypoxia treatment Our data indicated that miR-369 expression was significantly downregulated and TRPV3 was significantly upregulated in myocardial tissue after MI in rats and in hypoxic-treated neonatal rat cardiomyocytes (NRCMs). 33470394 3227 Rat rno-miR-369-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3228 Rat rno-miR-370 miRNA TGF-¦Â1 hepatic fibrogenesis hepatic stellate cells (HSCs) TGF-¦Â1 treatment downregulated 25686745 3229 Rat rno-miR-370 miRNA estradiol-17¦Â (E2) hormonal regulation adrenals?tissues estradiol-17¦Â (E2) treatment upregulated 24205079 3230 Rat rno-miR-370 miRNA H2O2 myocardial infarction (MI) H9C2 cells hydrogen peroxide (H2O2) treatment downregulated 31555385 3231 Rat rno-miR-370 miRNA hypoxia myocardial infarction (MI) Sprague-Dawley rats border area anterior descending artery was ligated with 7¨C0 ligation line 2 mm at the lower edge of the right in the left atrial appendage downregulated 28350072 3232 Rat rno-miR-370-3p miRNA chronic unpredictable mild stress (CUMS) depression hippocampus tissues chronic unpredictable mild stressed (CUMS) treatment downregulated 28083819 3233 Rat rno-miR-370-3p miRNA hronic unpredictable mild stressed (CUMS) depression rats hippocampal tissues stimulated daily with randomly applied mild stressors from among 14 different mild stressors downregulated 28083819 3234 Rat rno-miR-370-3p miRNA TGF-¦Â1 lung fibrosis lung fibroblasts TGF-¦Â1 treatment downregulated 32464548 3235 Rat rno-miR-370-3p miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) primary spinal neurons lipopolysaccharide (LPS) treatment SCI resulted in lncRNA H19 higher expression and miR-370-3p lower expression. 33708438 3236 Rat rno-miR-371b-5p miRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) lung tissues monocrotaline treatment miR-371b-5p was downregulated in PAH rats compared with the control group. 30387816 3237 Rat rno-miR-372 miRNA hypoxia spinal cord ischemia/reperfusion injury (SCII) PC-12 cells hypoxia induce upregulated 30298297 3238 Rat rno-miR-372-3p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia/reperfusion (I/R) injury primary neural stem cells (NSCs) were obtained from rat embryos oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 33579365 3239 Rat rno-miR-373-3p miRNA lipopolysaccharide (LPS) sepsis-induced acute hepatic injury liver tissues Lipopolysaccharide (LPS) treatment downregulated 33129786 3240 Rat rno-miR-374 miRNA N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) gastric cancer (GC) rats mesenchymal stem cells (MSCs) from the gastric tissues treat with MNNG upregulated in mesenchymal stem cells (MSCs) from the gastric tissues 28731132 3241 Rat rno-miR-374 miRNA sevoflurane (SEV) myocardial ischemia/reperfusion (I/R) injury (MIRI) ischemia-reperfusion (I/R) injuried rats heart tissues sevoflurane treatment upregulated 29689553 3242 Rat rno-miR-374-5p miRNA hypothermia fatal hypothermia iliopsoas muscle hypothermia treatment Mex3B expression was regulated by rno-miR-374-5p and decreased with decreasing body temperature. 32963265 3243 Rat rno-miR-374a miRNA CoCl2 hypoxia-induced injury PC-12 cells CoCl2 treatment downregulated 29247275 3244 Rat rno-miR-374a miRNA fortunellin inflammatory bowel disease (IBD) rat coliti Fortunellin treatment Fortunellin increased mir-374a expression. 29472916 3245 Rat rno-miR-374a miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells ?hypoxia/reoxygenation (H/R) induce downregulated 31265855 3246 Rat rno-miR-374a-5p miRNA oxygen glucose deprivation (OGD) apoptosis PC12 cells oxygen/glucose deprivation (OGD) induce treatment downregulated 31127537 3247 Rat rno-miR-375 miRNA doxorubicin (DOX) aoxorubicin-induced myocardial toxicity H9c2 cells Doxorubicin treatment Doxorubicin significantly upregulated miR-375 expression in vitro and in vivo. 32186283 3248 Rat rno-miR-375 miRNA diethylnitrosamine (DEN) carcinogen-initiated hepatocytes resistant-hepatocyte (R-H) rat diethyl nitrosamine (DEN) treatment downregulated 25010260 3249 Rat rno-miR-375 miRNA hepatocyte growth factor (HGF) cell migration mesenchymal stem cells (MSCs) hepatocyte growth factor (HGF) treatment downregulated 29322249 3250 Rat rno-miR-375 miRNA "2,4,6-trinitrobenzene sulfonic acid (TNBS)" colitis male Wistar rats inflamed colon "2,4,6-trinitrobenzene sulfonic acid (TNBS)/ethanol treatment" downregulated in inflamed colon 28572713 3251 Rat rno-miR-375 miRNA palmitate enteric neurons and gastrointestinal motility immorto postnatal enteric neuronal (IM-PEN) cell line palmitate treatment upregulated 24507550 3252 Rat rno-miR-375 miRNA cerulein or cyanohydroxybutene (CHB) exocrine pancreatic injury (EPIJ) serum cerulein or cyanohydroxybutene (CHB) treatment upregulated 24285669 3253 Rat rno-miR-375 miRNA cerulein or cyanohydroxybutene (CHB) exocrine pancreatic injury (EPIJ) serum rats were administered cerulein or CHB to induce EPIJ treatment upregulated 24285669 3254 Rat rno-miR-375 miRNA hypoxia hepatocellular carcinoma (HCC) HCCs hypoxia treatment "MiR-375 presented an obviously differential expression in human HCCs versus background livers (BLs) and HCCs versus normal liver tissues (NLTs). In rat models, miR-375 was gradually declined during hepatocarcinogenesis." 32215815 3255 Rat rno-miR-375 miRNA furan hepatotoxicity liver Furan treatment downregulated 27371368 3256 Rat rno-miR-375 miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment upregulated 27041227 3257 Rat rno-miR-375 miRNA ellagic acid (EA) breast cancer female rat mammary tissue ellagic acid treatment "ellagic acid, which inhibited E2-induced mammary tumorigenesis in our previous study, reversed the dysregulation of miR-375, miR-206, miR-182, miR-122, miR-127 and miR-183 detected with E2treatment" 23791885 3258 Rat rno-miR-375 miRNA lipopolysaccharide (LPS) neuronal cell injury N9 cells endotoxin treatment upregulated 26631961 3259 Rat rno-miR-375 miRNA calycosin neuroprotective effects middle cerebral artery occlusion (MCAO) rats calycosin treatment upregulated 24548484 3260 Rat rno-miR-375 miRNA streptozocin (STZ) pancreatic injury acinar cells Streptozotocin (STZ) treatment upregulated 27521901 3261 Rat rno-miR-375 miRNA 6-hydroxydopamine (6-OHDA) parkinson's disease (PD) substantia nigra 6-hydroxydopamine (6-OHDA) treatment "Compared with the normal group, the expression of miR-375 in the substantia nigra of rats in the model group was decreased." 33245094 3262 Rat rno-miR-375 miRNA adjuvant rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) adjuvant treatment downregulated 25619565 3263 Rat rno-miR-375 miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment upregulated 21094214 3264 Rat rno-miR-375 miRNA immobilization (IMO) stress synthesis and secretion of catecholamines Wistar rats adrenal medulla chromaffin cells exposed to IMO stress downregulated in rat adrenal medulla chromaffin cells 28356269 3265 Rat rno-miR-375 miRNA TianMai Xiaoke tablet(TM) type 2 diabetes mellitus (T2DM) diabetic rats islet TM treatment upregulated 24812635 3266 Rat rno-miR-375-3p miRNA angiotensin II (Ang II) cardiac hypertrophy primary cardiomyocyte angiotensin II (Ang II) treatment upregulated 30618075 3267 Rat rno-miR-375-3p miRNA ionizing radiation (IR) cell death ?rat pancreatic ¦Â cell line RIN-5F 7 Gy irradiation exposure upregulated 30930975 3268 Rat rno-miR-375-3p miRNA streptozocin (STZ) cell death ?rat pancreatic ¦Â cell line RIN-5F streptozotocin (STZ) treatment upregulated 30930975 3269 Rat rno-miR-375-3p miRNA hypoxia congenital heart disease (CHD) H9C2 cells hypoxia induce miR-375-3p was upregulated and FOXP1/Bcl2l2 was downregulated in maternal serum of women with fetal CHD and hypoxia-induced rat cardiomyocyte h9c2 cells. 33128129 3270 Rat rno-miR-375-3p miRNA hypoxia congenital heart disease (CHD) H9c2 cells hypoxia treatment miR-375-3p was upregulated in hypoxia-induced rat cardiomyocyte h9c2 cells. 33128129 3271 Rat rno-miR-375-3p miRNA high fructose liver fibrosis rat liver tissues and BRL-3A cells and/or primary rat hepatocytes high fructose treatment downregulated 30568253 3272 Rat rno-miR-375-3p miRNA Magnesium isoglycyrrhizinate (MgIG) liver fibrosis high fructose-treated rat liver tissues and BRL-3A cells and/or primary rat hepatocytes Magnesium isoglycyrrhizinate treatment magnesium isoglycyrrhizinate increased miR-375-3p expression to suppress the JAK2/STAT3 pathway and TGF-¦Â1/Smad signaling in these animal and cell models. 30568253 3273 Rat rno-miR-375-3p miRNA Magnesium isoglycyrrhizinate (MgIG) liver fibrosis liver tissues; BRL-3A cells; primary rat hepatocytes magnesium isoglycyrrhizinate treatment magnesium isoglycyrrhizinate increased miR-375-3p expression in liver fibrosis models. 30568253 3274 Rat rno-miR-375-3p miRNA hypoxia pulmonary microvascular endothelial cells (PMECs) injury Pulmonary microvascular endothelial cells (PMECs) hypoxia treatment The expression of miR-375-3p and Notch1 in the PMECs was significantly downregulated and upregulated during hypoxia. 32644005 3275 Rat rno-miR-376a miRNA human chorionic gonadotrophin (hCG) expression regulation Female 21-day-old Wistar rats 12 h after with (hCG) treatment upregulated 25279841 3276 Rat rno-miR-376a-3p miRNA fluorine combined with aluminum (FA) fluorine combined with aluminum (FA)-induced developmental neurotoxicity hippocampi fluorine combined with aluminum (FA) treatment upregulated 30033483 3277 Rat rno-miR-376b-3p miRNA noradrenaline (NA) cardiac hypertrophy neonatal rat ventricular cells (NRVCs) noradrenaline (NA) treatment downregulated 29570827 3278 Rat rno-miR-376b-3p miRNA ischemia periodontitis Serum Ligation around teeth treatment upregulated 26910654 3279 Rat rno-miR-376c miRNA electroacupuncture (EA) hyperactivity of the HPA axis induced by hepatectomy rats electroacupuncture (EA) treatment upregulated 29021740 3280 Rat rno-miR-376c-3p miRNA oxygen glucose deprivation (OGD) neonatal hypoxic-ischemic encephalopathy PC-12 cells oxygen-glucose deprivation (OGD) treatment downregulated 31844418 3281 Rat rno-miR-377 miRNA hypoxia/reoxygenation (H/R) acute myocardial infarction (AMI) H9c2 cells hypoxia/reoxygenation (H/R) treatment upregulated 32674625 3282 Rat rno-miR-377 miRNA fructose glomerular podocyte injury kidney cortex tissues fructose-fed treatment upregulated 25746774 3283 Rat rno-miR-377 miRNA estradiol-17¦Â (E2) hormonal regulation adrenals?tissues estradiol-17¦Â (E2) treatment upregulated 24205079 3284 Rat rno-miR-377 miRNA hypoxia ischemic stroke (IS) Primary rat microglial cells and brain microvascular endothelial cells (BMECs) oxygen-glucose deprivation (OGD) treatment downregulated 28569430 3285 Rat rno-miR-377 miRNA oxygen glucose deprivation (OGD) ischemic stroke (IS) primary rat microglial cells and brain microvascular endothelial cells (BMECs) oxygen-glucose deprivation (OGD) treatment downregulated 28569430 3286 Rat rno-miR-377* miRNA oxygen lung injury pregnant rats lung tissue inspired oxygen of 10.5 or 22% for two days treatment upregulated 25120593 3287 Rat rno-miR-377-5p miRNA propofol (PPF) neurotoxicity primary cultured neural stem cells (NSCs) propofol treatment upregulated 29679758 3288 Rat rno-miR-378 miRNA TGF-¦Â adaptation of tendons to mechanical loading rat Tendon fibroblasts Transforming growth factor-¦Â(TGF-¦Â) treatment upregulated 22539168 3289 Rat rno-miR-378 miRNA astragaloside IV (AS-IV) diabetic nephropathy (DN) diabetic rats kidney tissues astragaloside (AS-IV) treatment upregulated 29792879 3290 Rat rno-miR-378 miRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissues streptozotocin (STZ) treatment downregulated 29792879 3291 Rat rno-miR-378 miRNA TGF-¦Â1 kidney fibrosis and mesangial hypertrophy NRK52E and mesangial cells TGF-¦Â1 treatment downregulated 28053239 3292 Rat rno-miR-378 miRNA hypoxia vascularization Sprague-Dawley rats mesenchymal stem cells (MSCs) hypoxia treatment downregulated 25418617 3293 Rat rno-miR-378a miRNA mitomycin C-polylactic acid ( MMC-PLA) film epidural scar hyperplasia and adhesion post-laminectomy rat scar tissues 25 mg of PLA film containing 0.01% MMC was implanted on the laminectomy area downregulated 28617531 3294 Rat rno-miR-378a miRNA cisplatin (DDP) liver damage urine cisplatin treatment upregulated 27397436 3295 Rat rno-miR-378a miRNA cisplatin (DDP) nephrotoxicity rats cisplatin treatment upregulated 27397436 3296 Rat rno-miR-378a-3p miRNA gentamicin acute kidney injury (AKI) urine gentamicin treatment upregulated 33263228 3297 Rat rno-miR-378a-3p miRNA acetaminophen (APAP) drug-induced liver injury (DILI) rat liver tissues acetaminophen (APAP) treatment downregulated 31468699 3298 Rat rno-miR-378a-3p miRNA acetaminophen (APAP) drug-induced liver injury (DILI) liver tissues acetaminophen (APAP) treatment CYP2E1 and miRNA-378a-3p contribute to acetaminophen- or tripterygium glycosides-induced hepatotoxicity. 31468699 3299 Rat rno-miR-378a-3p miRNA chlormethiazole (CMZ) drug-induced liver injury (DILI) rat liver tissues chlormethiazole (CMZ) treatment downregulated 31468699 3300 Rat rno-miR-378a-3p miRNA Tripterygium glycosides (TGs) drug-induced liver injury (DILI) rat liver tissues tripterygium glycosides (TG) treatment downregulated 31468699 3301 Rat rno-miR-378a-3p miRNA Tripterygium glycosides (TGs) drug-induced liver injury (DILI) liver tissues tripterygium glycosides (TG) treatment CYP2E1 and miRNA-378a-3p contribute to acetaminophen- or tripterygium glycosides-induced hepatotoxicity. 31468699 3302 Rat rno-miR-378a-3p miRNA doxorubicin (DOX) ischemia/reperfusion (I/R) injury rats cardiomyocytes doxorubicin treatment upregulated 27919821 3303 Rat rno-miR-378a-3p miRNA ischemia/reperfusion (I/R) kidney damage Sprague-Dawley rats urine ischemia/reperfusion (I/R) treatment upregulated 28056546 3304 Rat rno-miR-378a-3p miRNA notexin skeletal muscle atrophy plasma notexin treatment upregulated 26952641 3305 Rat rno-miR-378a-5p miRNA alcohol alcoholic cardiomyopathy (ACM) primary rat cardiomyocytes alcohol exposure upregulated 28160209 3306 Rat rno-miR-378a-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3307 Rat rno-miR-378b miRNA doxorubicin (DOX) ischemia/reperfusion (I/R) injury rats cardiomyocytes doxorubicin treatment downregulated 27919821 3308 Rat rno-miR-378b miRNA hypoxia obesity dietary-induced obese SD rats hypoxia exercise training treatment downregulated 25183036 3309 Rat rno-mir-378b miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3310 Rat rno-miR-379 miRNA trichostatin A (TSA) hepatocellular carcinoma (HCC) rat primary hepatocytes Trichostatin A (TSA)treatment treatment "miR-122, miR-143 and miR-379 could be related to the inhibitory effects of TSA on hepatocellular proliferation" 21513791 3311 Rat rno-miR-379 miRNA SiO2 lung injury lung SiO2 treatment upregulated 27689473 3312 Rat rno-miR-379 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment upregulated 27910957 3313 Rat rno-miR-379-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3314 Rat rno-miR-380-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3315 Rat rno-miR-381 miRNA dexmedetomidine (DEX) cerebral ischemia injury (CII) OGD/R-treated rat neuron cells dexmedetomidine (Dex) treatment upregulated 33314611 3316 Rat rno-miR-381 miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia injury (CII) neuron cells were isolated from the hippocampus of rats oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 33314611 3317 Rat rno-miR-381 miRNA dexmedetomidine (DEX) cerebral ischemia injury (CII) brain tissues dexmedetomidine (Dex) treatment Dex was found to increase the miR-381 expression. 33314611 3318 Rat rno-miR-381 miRNA dexmedetomidine (DEX) ropivacaine induced neurocyte injury PC12 cells dexamethasone (DEX) treatment "Dexmedetomidine reversed role of ropivacaine (0 mM, 0.1 mM, 0.5 mM, 1 mM) by upragulating the expression of miR-381 and suppressing the expression of LRRC4 in PC12 cells." 32467829 3319 Rat rno-miR-381-3p miRNA lipopolysaccharide (LPS) acute spinal cord injury (ASCI) Microglial BV2 cells Lipopolysaccharide (LPS) treatment downregulated 30229813 3320 Rat rno-miR-382 miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment upregulated 27041227 3321 Rat rno-miR-382 miRNA alcohol myocardial infarction (MI) the nucleus accumbens (NAc) alcohol exposure upregulated 23873704 3322 Rat rno-miR-382 miRNA acute stress (AS) and chronic stress (CS) stress-induced myocardial injury rat Rats were bound and suspended treatment upregulated 24669248 3323 Rat rno-miR-382 miRNA phosphorus (Pi) vascular calcification (VC) rat aortic vascular smooth muscle cells high levels of phosphate treatment downregulated 28522697 3324 Rat rno-miR-382* miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment upregulated 27041227 3325 Rat rno-miR-382-3p miRNA chronic unpredictable mild stress (CUMS) depression hippocampus tissues chronic unpredictable mild stressed (CUMS) treatment upregulated 28083819 3326 Rat rno-miR-382-3p miRNA hronic unpredictable mild stressed (CUMS) depression rats hippocampal tissues stimulated daily with randomly applied mild stressors from among 14 different mild stressors upregulated 28083819 3327 Rat rno-miR-382-5p miRNA chronic unpredictable mild stress (CUMS) depression hippocampus chronic unpredictable mild stress (CUMS) treatment upregulated 32982244 3328 Rat rno-miR-383 miRNA propofol (PPF) anesthesia-induced cognitive impairment hippocampus propofol treatment Propofol treatment significantly reduced the relative mRNA expression of miR-383 29545833 3329 Rat rno-miR-383 miRNA piperine myocardial ischemia/reperfusion (I/R) injury (MIRI) heart tissues Piperine (PIP) treatment MIRI-caused elevation of miR-383 and decrease of RP105/PI3K/AKT pathway were reverted by PIP treatment 33219747 3330 Rat rno-miR-383 miRNA piperine myocardial ischemia/reperfusion (I/R) injury (MIRI) rat cardiomyocytes Piperine (PIP) treatment ?MIRI-caused elevation of miR-383 and decrease of RP105/PI3K/AKT pathway were reverted by PIP treatment 33219747 3331 Rat rno-miR-383-3p miRNA high fat diet (HFD) coronary atherosclerosis (CAS) myocardial tissues high fat diet (HFD) feed MiR-383-3p was downregulated in myocardial tissues of AS rats. 29693751 3332 Rat rno-miR-383-5p miRNA cold cold stress rats serum cold conditions (4¡æ for 12h) downregulated 28477904 3333 Rat rno-miR-383-5p miRNA sorafenib (SOR) hepatocellular carcinoma (HCC) pulmonary metastatic tissue sorafenib treatment upregulated 26026584 3334 Rat rno-miR-383-5p miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC-12 cells lipopolysaccharide (LPS) treatment The results showed that lncRNA CASC9 was downregulated and miR-383-5p was upregulated in SCI rats and LPS-induced PC12 cells. 33438067 3335 Rat rno-miR-383-5p miRNA hypoxia stroke middle cerebral artery occlusion (MCAO) Sprague-Dawley rat middle cerebral artery occlusion (MCAO) treatment upregulated 29113076 3336 Rat rno-miR-384 miRNA epigallocatechin-3-gallate (EGCG) myocardial ischemia/reperfusion (I/R) injury (MIRI) hypoxia-induced H9c2 cell lines EGCG treatment upregulated 31802847 3337 Rat rno-miR-384 miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cell lines hypoxia induce downregulated 31802847 3338 Rat rno-miR-384 miRNA oxygen glucose deprivation (OGD) neonatal hypoxic-ischemic encephalopathy Neonatal rat primary microglia cells oxygen-glucose deprivation (OGD) treatment The expression of miR-384 was decreased in the serum of HIE newborns and OGD-induced activated microglia. 32621118 3339 Rat rno-miR-384-5p miRNA TGF-¦Â cardiac fibrosis Primary cardiac fibroblasts (CFs) TGF-¦Â treatment downregulated 30206318 3340 Rat rno-miR-384-5p miRNA TGF-¦Â cardiac fibrosis cardiac fibroblasts (CFs) TGF-¦Â treatment TGF-¦Â treatment also significantly decreased the expression of miR-384-5p in CFs 30206318 3341 Rat rno-miR-384-5p miRNA angiotensin II (Ang II) cardiac hypertrophy H9c2 cells angiotensin II (Ang II) treatment downregulated 32436661 3342 Rat rno-miR-384-5p miRNA trimethyltin (TMT) neurotoxicity rats serum were given a single administration of TMT treatment upregulated 24777749 3343 Rat rno-miR-384-5p miRNA ischemia myogenic differentiation ischemic myocardium of rats;H9c2 cells ischemia treatment downregulated 23315007 3344 Rat rno-miR-39a miRNA high fat diet (HFD) insulin resistance (IR) C57BL/6 mice high fat diet (HFD) feed upregulated 24844433 3345 Rat rno-miR-409 miRNA isoflurane isoflurane-induced neurotoxicity hippocampal neurons; PC-12 cells isoflurane treatment Vitexin could significantly increase the expression of miR-409. 32011832 3346 Rat rno-miR-409-5p miRNA hypoxia myocardial hypoxic/ischemic injury H92c cells hypoxia treatment USP7 expression was markedly elevated while miR-409-5p expression was significantly downregulated in H9c2 cells under hypoxic culture. 33241864 3347 Rat rno-miR-409-5p miRNA pegylated rat leptin antagonist (pRLA) type 2 diabetes mellitus (T2DM) rat muscle and liver pegylated rat leptin antagonist (pRLA) treatment "upregulation of rno-miR-10a at d28 and rno-miR-200a, rno-miR-409-5p, and rno-miR-125a-3p following HFD challenge" 23576026 3348 Rat rno-miR-409a-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3349 Rat rno-miR-409a-5p miRNA TGF-¦Â1 lung fibrosis lung fibroblasts TGF-¦Â1 treatment downregulated 32464548 3350 Rat rno-mir-409b miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3351 Rat rno-miR-410 miRNA 6-hydroxydopamine (6-OHDA) parkinson's disease (PD) PC12 cells 6-hydroxydopamine (6-OHDA) treatment downregulated 31067440 3352 Rat rno-miR-410 miRNA bleomycin (BLM) lung fibrosis lung tissues bleomycin A5 treatment upregulated 30157485 3353 Rat rno-miR-410 miRNA bleomycin (BLM) lung fibrosis pulmonary fibrosis rats lung tissues Prodigiosin (PG) treatment downregulated 30157485 3354 Rat rno-miR-410-3p miRNA streptozocin (STZ) diabetic retinopathy (DR) rat retinal streptozotocin (STZ)-induced diabetic rat treatment differential expressions 24502381 3355 Rat rno-miR-410-3p miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells hypoxia/reoxygenation (H/R) treatment FTX alleviates hypoxia/reoxygenation-induced cardiomyocyte injury via miR-410-3p/Fmr1 axis 31957854 3356 Rat rno-miR-410-3p miRNA sevoflurane (SEV) postoperative cognitive dysfunction (POCD) hippocampal neuron sevoflurane anesthesia-induce treatment downregulated 31350734 3357 Rat rno-miR-410-5p miRNA high fat diet (HFD) cardiac remodeling heart tissues high fat diet (HFD) feed upregulated 29884823 3358 Rat rno-miR-410-5p miRNA propofol (PPF) neurotoxicity primary cultured neural stem cells (NSCs) propofol treatment downregulated 29679758 3359 Rat rno-miR-411 miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) microglia lipopolysaccharide (LPS) treatment MiRNA-411 increase ameliorates the inflammatory microglia-induced neurological lesion and promotes neural recovery by JNK pathway inhibition via negative targeting IL-18 in SCI. 32016950 3360 Rat rno-miR-411-3p miRNA silica lung fibrosis lung tissues silica treatment downregulated 32004504 3361 Rat rno-miR-411-3p miRNA TGF-¦Â1 lung fibrosis primary fibroblasts TGF-¦Â1 treatment downregulated 32004504 3362 Rat rno-miR-411-3p miRNA TGF-¦Â1 lung fibrosis lung fibroblasts TGF-¦Â1 treatment downregulated 32464548 3363 Rat rno-miR-411-3p miRNA herb-partitioned moxibustion ulcerative colitis (UC) UC rats colon tissues herb-partitioned moxibustion upregulated 28246536 3364 Rat rno-miR-421 miRNA hypoxia hypoxia-induced injury H9c2 cells hypoxia induce upregulated 31469043 3365 Rat rno-miR-421 miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H92c cells hypoxia/reoxygenation treatment MiR-421 inhibition protects H9c2 cells against hypoxia/reoxygenation-induced oxidative stress and apoptosis by targeting Sirt3. 31469043 3366 Rat rno-miR-423-3p miRNA house dust mite (HDM) extract allergic airway inflammation adipose tissue and lungs house dust mite extract treatment upregulated 32887419 3367 Rat rno-miR-423-5p miRNA ischemia/reperfusion (I/R) acute kidney injury (AKI) rats kidney tissues ischemia/reperfusion (I/R) treatment upregulated in rat kidneys 29137244 3368 Rat rno-miR-423-5p miRNA lipopolysaccharide (LPS) acute respiratory distress syndrome (ARDS) lung tissues lipopolysaccharide (LPS) treatment "The expression of H19 and FOXA1 was significantly upregulated, while the expression of miR-423-5p was downregulated in LPS-induced ARDS rats." 33629893 3369 Rat rno-miR-423-5p miRNA huoxue jiedu formula (HXJDF) diabetic retinopathy (DR) retinal tissues HuoXue JieDu Formula (HXJDF) treatment miR-423-4p was downregulated in HuoXue JieDu Formula (HXJDF) treated group when compared with diabetic mice. 33271246 3370 Rat rno-miR-423-5p miRNA hypoxia hypoxia-induced injury H9C2 cells hypoxia induce upregulated 31074036 3371 Rat rno-miR-423-5p miRNA H2O2 spinal cord injury (SCI) PC-12 cells H2O2 treatment upregulated 30977409 3372 Rat rno-miR-424 miRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissues streptozotocin treatment downregulated 30637733 3373 Rat rno-miR-424 miRNA carbon tetrachloride (CCl4) liver fibrosis liver tissues carbon tetrachloride (CCl4) treatment upregulated 33333053 3374 Rat rno-miR-424 miRNA carbon tetrachloride (CCl4) liver fibrosis rat liver tissue CCl4 treatment "miR-322/424 level in liver cirrhosis patients, mouse liver fibrosis induced by CCl4?and BDL, and rat liver fibrosis induced by CCl4?and dimethylnitrosamine was increased." 33333053 3375 Rat rno-miR-425 miRNA sevoflurane (SEV) acute lung injury (ALI) lung tissues sevoflurane treatment downregulated 28617947 3376 Rat rno-miR-425-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3377 Rat rno-miR-425-5p miRNA cold cold stress rats serum cold conditions (4¡æ for 12h) downregulated 28477904 3378 Rat rno-miR-4262 miRNA tumor necrosis factor alpha (TNF-¦Á) osteoarthritis (OA) chondrocytes were separated from Sprague-Dawley rats tumor necrosis factor alpha (TNF-¦Á) treatment upregulated 29434702 3379 Rat rno-miR-4262 miRNA tumor necrosis factor alpha (TNF-¦Á) osteoarthritis (OA) Primary chondrocytes tumor necrosis factor alpha (TNF-¦Á) treatment upregulated 29434702 3380 Rat rno-miR-429 miRNA N-methyl-N-nitrosourea (MNU) breast cancer rats with experimental breast cancer Thoracic Duct Lymph N-Methyl-N-Nitrosourea dysregulatedin Thoracic Duct Lymph 28091921 3381 Rat rno-miR-429 miRNA comfrey tumorigenesis rat liver comfrey treatment upragulated 21370286 3382 Rat rno-miR-429 miRNA angiotensin II (Ang II) epithelial-mesenchymal transition (EMT) NRK-52E cells angiotensin II (Ang II) treatment downregulated 30132344 3383 Rat rno-miR-429 miRNA aflatoxin B1 (AFB1) hepatotoxicant and genotoxicant liver aflatoxin B1 (AFB1) treatment upregulated 26385312 3384 Rat rno-miR-429 miRNA angiotensin II (Ang II) hypertensive nephropathy (HN) rat renal artery endothelial cells (RRAECs) angiotensin II (Ang II) treatment upregulated 32346437 3385 Rat rno-miR-429 miRNA "DDT (2,2-dichlorodiphenyl-1,1,1-trichloroethane), benzo[a]pyrene (BP), and 3-methylcholanthrene (MC)" post-transcriptional regulation ?the livers and ovaries of chemically induced rats "DDT, benzo[a]pyrene (BP), and 3-methylcholanthrene (MC) treatment" downregulated 24727239 3386 Rat rno-miR-429 miRNA lipopolysaccharide (LPS) myocarditis H9c2 cells lipopolysaccharide (LPS) treatment upregulated 31876239 3387 Rat rno-miR-429 miRNA swainsonine (SW) myocarditis LPS-treated H9c2 cells Swainsonine (SW) treatment downregulated 31876239 3388 Rat rno-miR-429 miRNA CoCl2 neuron apoptosis PC12 cells cobalt chloride (CoCl2) treatment downregulated 32004541 3389 Rat rno-miR-429 miRNA ketamine neurotoxicity PC12 cells Ketamine treatment miR-429 attenuates ketamine-induced neurotoxicity in PC12 cells by the downregulated of BAG5. 33283947 3390 Rat rno-miR-429 miRNA ketamine neurotoxicity PC12 cells ketamine treatment The qRT-PCR results showed that miR-429 expression was downregulated by treatment of ketamine in a dose-dependent manner.? Overexpression of miR-429 alleviated ketamine-induced neurotoxicity in PC12 cells. 33283947 3391 Rat rno-miR-429 miRNA swainsonine (SW) pediatric myocarditis (PM) H9c2 cells swainsonine (SW) treatment MiR-429 expression was elevated by LPS and suppressed by SW 31876239 3392 Rat rno-miR-429 miRNA high salt (HS) salt-sensitive hypertension Sprague-Dawley rats renal medullary tissues high-salt diet (8% NaCl) upregulated 28445205 3393 Rat rno-miR-429 miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC13 cell lipopolysaccharide (LPS) treatment ?miR-429 was downregulated in LPS-stimulated PC12 cells. Overexpression of miR-429 contributed to LPS-induced PC12 injuries. 31309444 3394 Rat rno-miR-429-3p miRNA dexmedetomidine (DEX) chemotherapy-induced cognitive impairment (CICI) brain tissues dexmedetomidine (Dex) treatment Dexmedetomidine attenuates cisplatin-induced cognitive impairment by modulating miR-429-3p expression in rats 32411568 3395 Rat rno-miR-431 miRNA H2O2 acute myocardial infarction (AMI) H9c2 cells H2O2 treatment We revealed that miR-431 expression was decreased in H2O2-treated H9c2 cells and myocardium of MI rats. 33660818 3396 Rat rno-miR-432-5p miRNA high fat diet (HFD) insulin resistance (IR) liver tissues high fat diet (HFD) feed upregulated 29802941 3397 Rat rno-miR-432-5p miRNA physical exercise insulin resistance (IR) diet-induced obesity rats liver tissues physical exercise treatment downregulated 29802941 3398 Rat rno-miR-434 miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment upregulated 27041227 3399 Rat rno-miR-434-3p miRNA notexin skeletal muscle atrophy plasma notexin treatment upregulated 26952641 3400 Rat rno-miR-434-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3401 Rat rno-miR-434-5p miRNA artemisinin (ART) ventricular arrhythmias (VA) transverse aortic constriction (TAC) surgery treated rats left ventricle (LV) tissues artemisinin (ART) treatment upregulated 30595983 3402 Rat rno-miR-448 miRNA lead (Pb) nervous system diseases rats hippocampus chronic lead exposure treatment upregulated 24960059 3403 Rat rno-miR-448 miRNA sevoflurane (SEV) neural function left cortex of the brain Sevoflurane treatment significantly increased 26021509 3404 Rat rno-miR-448 miRNA isoflurane neuron apoptosis Sprague-Dawley rats hippocampus tissues isoflurane treatment upregulated in rat hippocampus tissue 29067448 3405 Rat rno-miR-448 miRNA freund¡¯s complete adjuvant (FCA) rheumatoid arthritis (RA) synovial tissues Freund¡¯s complete adjuvant (FCA) treatment lncRNA OIP5-AS1 may mitigate RA progression through the miR-448-PON1 axis and through the inactivation of the TLR3-NF-¦ÊB signalling pathway. 32770578 3406 Rat rno-miR-448 miRNA hypoxia spinal cord ischemia/reperfusion injury (SCII) PC12 cells hypoxia induce upregulated 29561961 3407 Rat rno-miR-448-3p miRNA high glucose (HG) diabetes-associated endothelial dysfunction rat aortic endothelial cells high glucose (HG) treatment downregulated 32542696 3408 Rat rno-miR-448-3p miRNA streptozocin (STZ) diabetes-associated endothelial dysfunction aorta streptozocin (STZ) treatment downregulated 32542696 3409 Rat rno-miR-448-3p miRNA fluorine combined with aluminum (FA) fluorine combined with aluminum (FA)-induced developmental neurotoxicity hippocampi fluorine combined with aluminum (FA) treatment upregulated 30033483 3410 Rat rno-miR-448-5p miRNA letrozole polycystic ovarian syndrome (PCOS) ovarian tissues letrozole treatment downregulated 29505837 3411 Rat rno-miR-449 miRNA cisplatin (DDP) acute kidney injury (AKI) NRK-52E cells cisplatin treatment upregulated 26968221 3412 Rat rno-miR-449a miRNA hypoxia cardiomyocytes injury H9c2 cells hypoxia induce upregulated 30770559 3413 Rat rno-miR-449a miRNA tetramethylpyrazine (TMP) cardiomyocytes injury hypoxia-induced H9c2 cells Tetramethylpyrazine treatment downregulated 30770559 3414 Rat rno-miR-449a miRNA sodium nitrate diabetic testicular disorder diabetic rats testis tissues sodium nitrate feed treatment upregulated 30952494 3415 Rat rno-miR-449a miRNA streptozocin (STZ) diabetic testicular disorder testis tissues streptozotocin (STZ) treatment downregulated 30952494 3416 Rat rno-miR-449a miRNA light focal retinal degeneration right eye light treatment upregulated 25921151 3417 Rat rno-miR-449a miRNA ethylene glycol monomethyl ether (EGME) hyperglycemia ?testicle of rat Ethylene glycol monomethyl ether (EGME) treatment "miR-449a and miR-92a decreased obviously and, miR-320, miR-134 and miR-188 increased" 22008535 3418 Rat rno-miR-449a miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) neonatal rat ventricular myocytes and H9C2 cells hypoxia induce upregulated 29758550 3419 Rat rno-miR-449a miRNA lead (Pb) nervous system diseases rats hippocampus chronic lead exposure treatment upregulated 24960059 3420 Rat rno-miR-449a miRNA electroacupuncture (EA) spinal cord injury (SCI) SCI rats modified Allen's method downregulated 28507480 3421 Rat rno-miR-449a miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) spinal cord tissues; HAPI cells lipopolysaccharide (LPS) treatment upregulated 30119293 3422 Rat rno-miR-449a-5p miRNA H2O2 hyperoxia-induced acute lung injury (HALI) rat type II alveolar epithelial cells (AECII) hydrogen peroxide (H2O2) treatment downregulated 29436647 3423 Rat rno-miR-449a-5p miRNA hypoxia pulmonary arterial hypertension (PAH) pulmonary arterial smooth muscle cells (PASMCs) hypoxia induce downregulated 30715622 3424 Rat rno-miR-450a miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 3425 Rat rno-miR-451 miRNA platelet derived growth factor-BB (PDGF-BB) atherosclerosis (AS) vascular smooth muscle cells (VSMCs) platelet-derived growth factor type BB (PDGF-BB) treatment downregulated 30930138 3426 Rat rno-miR-451 miRNA genistein cardiac hypertrophy isoproterenol-treated H9C2 cells genistein treatment upregulated 30798118 3427 Rat rno-miR-451 miRNA isoproterenol cardiac hypertrophy H9C2 cells isoprenaline (ISO) tteatment downregulated 30798118 3428 Rat rno-miR-451 miRNA immunoregulatory molecule soluble HLA-G (sHLA-G) CD4+ T cells proliferation CD4+ T cells immunoregulatory molecule soluble HLA-G (sHLA-G) treatment "sHLA-G triggered a modulation of miRNA expression that may in turn modulate downstream gene expression, thus affecting CD4+ T -cell function." 23220581 3429 Rat rno-miR-451 miRNA trans-chalcone hepatoprotective action of trans-chalcone liver tissues trans-chalcone treatment Trans-chalcone increased hepatic level of miR-451 and reduced hepatic IL-8 as well as AST and ALT aft er 6 weeks 29453920 3430 Rat rno-miR-451 miRNA propofol (PPF) myocardial ischemia/reperfusion (I/R) injury (MIRI) hypoxia treated H9C2 cells Propofol treatment upregulated 31188485 3431 Rat rno-miR-451 miRNA anoxia/reoxygenation (A/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) neonatal rat ventricular cardiomyocytes anoxia/reoxygenation (A/R) treatment downregulated 27121079 3432 Rat rno-miR-451 miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) treatment downregulated 32256945 3433 Rat rno-miR-451 miRNA palmitic acid (PA) obesity and diabetes cardiac myocytes high-fat diet (HFD) treatment upregulated 25362209 3434 Rat rno-miR-451 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment upregulated 27910957 3435 Rat rno-miR-451 miRNA perfluorooctane sulfonic acid (PFOS) perfluorooctane sulfonate (PFOS)-induced toxic action rat liver tissue dams received 3.2 mg/kg PFOS in their feed from gestational day 1 (GD1) to postnatal day 7 (PND 16) treatment different expression 24420840 3436 Rat rno-miR-451 miRNA Silica nanoparticles (SiNPs) vascular endothelial dysfunction aortic arch Silica nanoparticles (SiNPs) treatment downregulated 30975181 3437 Rat rno-miR-451 miRNA heat stress vascular permeability lung endothelial cells heat treatment "MiRNA-451 was upregulated in the lung endothelial cells of the rat model, and contributed to increase lung endothelial cell permeability." 33269809 3438 Rat rno-miR-451-5p miRNA methamphetamine (METH) methamphetamine (METH) addiction brain tissues Methamphetamine (METH) treatment downregulated 32893733 3439 Rat rno-miR-454 miRNA carbon tetrachloride (CCl4) liver cirrhosis liver tissues CCl4 treatment downregulated 30535384 3440 Rat rno-miR-454 miRNA TGF-¦Â1 liver cirrhosis HSC-T6 cells transforming growth factor (TGF)-¦Â1 treatment downregulated 30535384 3441 Rat rno-miR-454 miRNA pioglitazone oxygen glucose deprivation (OGD)-induced myocardial cell injury H9c2 cells pioglitazone treatment Pioglitazone significantly upregulated miR-454 expression in OGD-injured cells 30524679 3442 Rat rno-miR-455 miRNA hypoxia/reoxygenation (H/R) hepatic ischemia/reperfusion injury (HIRI) BRL-3A cells hypoxia-reoxygenation (H/R) treatment lncRNA Gm4419 accelerates hepatic I/R injury by targeting the miR-455-SOX6 axis. 32114773 3443 Rat rno-miR-455-3p miRNA cadmium (Cd) cadmium (Cd)-induced kidney injury renal cortex cadmium (Cd) treatment downregulated 29543730 3444 Rat rno-miR-455-3p miRNA bicyclol idiopathic pulmonary fibrosis (IPF) IPF rat lung tissues bicyclol treatment upregulated 31407409 3445 Rat rno-miR-455-3p miRNA hypoxia/reoxygenation (H/R) ischemia/reperfusion (I/R) injury mesenchymal stem cell (MSC) exosome hypoxia-reoxygenation (H/R) treatment upregulated 32719674 3446 Rat rno-miR-455-3p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) PC12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 33528807 3447 Rat rno-miR-455-3p miRNA TGF-¦Â1 liver fibrosis hepatic stellate cells (HSC-T6) transforming growth factor ¦Â1 (TGF-¦Â1) treatment downregulated 31150929 3448 Rat rno-miR-455-3p miRNA thioacetamide (TAA) liver toxicity Sprague-Dawley rats livers "treat with TAA at three doses (4.5, 15 and 45 mg/kg) and four time points (3-, 7-, 14- and 28-days) treatment" dysregulatedin livers 28596526 3449 Rat rno-miR-455-5p miRNA Smad3 inhibitor (SIS3) intrauterine adhesion (IUA) endometrial stromal cells (ESCs) Smad3 inhibitor (SIS3) treatment downregulated 32447720 3450 Rat rno-miR-455-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) brain tissues oxygen-glucose deprivation and reoxygenation (OGD/R) treatment miR-455-5p expression was reduced in brain tissues of MCAO rats and OGD/R-induced PC12 cells 33309710 3451 Rat rno-miR-465* miRNA oxygen lung injury pregnant rats lung tissue inspired oxygen of 10.5 or 21% for two days treatment upregulated 25120593 3452 Rat rno-miR-466 miRNA single dose irradiation radiation-induced lung injury (RILI) male Wistar rats lung tissues subjected to single dose irradiation with 20 Gy using 6 MV x-rays to the right lung treatment upregulated 24886372 3453 Rat rno-miR-466b miRNA hypoxia cortical injury rat cortex tisssues hypoxia treatment downregulated 23272113 3454 Rat rno-miR-466b miRNA adreno-cortico-tropic-hormone (ACTH) hormonal regulation adrenals?tissues adreno-cortico-tropic-hormone (ACTH) treatment downregulated 24205079 3455 Rat rno-miR-466b miRNA dexamethasone (DEX) hormonal regulation adrenals?tissues dexamethasone (DEX) treatment downregulated 24205079 3456 Rat rno-miR-466b miRNA estradiol-17¦Â (E2) hormonal regulation adrenals?tissues estradiol-17¦Â (E2) treatment downregulated 24205079 3457 Rat rno-miR-466b miRNA perfluorooctane sulfonic acid (PFOS) neural dysfunctions rat brains perfluorooctane sulfonic acid (PFOS) treatment downregulated 22594572 3458 Rat rno-miR-466b miRNA acute stress (AS) and chronic stress (CS) stress-induced myocardial injury rat Rats were bound and suspended treatment downregulated 24669248 3459 Rat rno-miR-466b-1FNx01 miRNA propofol (PPF) neural function left cortex of the brain Propofol treatment significantly increased 26021509 3460 Rat rno-miR-466b-1FNx01 miRNA sevoflurane (SEV) neural function left cortex of the brain Sevoflurane treatment significantly increased 26021509 3461 Rat rno-miR-466b-2-3p miRNA methylprednisolone steroid-induced osteonecrosis of femoral head (ONFH) bone microvascular endothelial cells (BMECs) methylprednisolone treatment downregulated 29408208 3462 Rat rno-miR-466b-5p miRNA propofol (PPF) neurotoxicity primary cultured neural stem cells (NSCs) propofol treatment downregulated 29679758 3463 Rat rno-miR-466b-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3464 Rat rno-miR-466c-5p miRNA vitamin A congenital scoliosis (CS) Embryos Vitamin A deficiency treatment upregulated 31044535 3465 Rat rno-miR-466f miRNA valproic acid (VPA) cerebral ischemia injury (CII) rat cortical neuronal cells valproic acid treatment upregulated 22937209 3466 Rat rno-miR-466i miRNA palmitate and palmitate plus oleate. insulin resistance (IR) mouse myoblasts palmitate and palmitate plus oleate treatment upregulated 21183973 3467 Rat rno-miR-466i-5p miRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia treatment "Kcnq1ot1 sponged miR-466k and miR-466i-5p to up-regulate Tead1, thus triggering cardiomyocyte injury in the process of AMI." 32422306 3468 Rat rno-miR-466k miRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia treatment "Kcnq1ot1 sponged miR-466k and miR-466i-5p to up-regulate Tead1, thus triggering cardiomyocyte injury in the process of AMI." 32422306 3469 Rat rno-miR-4728-5p miRNA H2O2 age-related cataract (ARC) human lens epithelial cells (LECs) oxidative stress NONHSAT143692.2 is involved in oxidative DNA damage repair in the lens by regulating the miR-4728-5p/OGG1 axis. 33000245 3470 Rat rno-miR-483 miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment upregulated 27041227 3471 Rat rno-miR-483 miRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment downregulated 30373531 3472 Rat rno-miR-483 miRNA grape seed procyanidin extract (GSPE) pancreatic islet injury rat islets grape seed procyanidin extract (GSPE)treatment "GSPE altered significantly the expression of miR-1249, miR-483, miR-30c-1*, and miR-3544." 23215023 3473 Rat rno-miR-483-5p miRNA palmitate diabetes mellitus (DM) INS-1 cells palmitate (Pal) treatment upregulated 30131392 3474 Rat rno-miR-483-5p miRNA inorganic phosphate (Pi) vascular calcification (VC) Vascular Smooth Muscle Cells Inorganic phosphate (Pi) treatment upregulated 31790973 3475 Rat rno-miR-484 miRNA doxorubicin (DOX) doxorubicin (DOX)-induced cardiotoxicity primary cultured myocardial cells (PC); H9c2 cells doxorubicin (DOX) treatment downregulated 30170730 3476 Rat rno-miR-485 miRNA hypoxia ischemic stroke (IS) mouse brain tissues middle cerebral artery occlusion (MCAO) downregulated 31794744 3477 Rat rno-miR-485-3p miRNA FK506 osteogenesis rat bone marrow stromal cells (BMSCs) FK506 treatment upregulated 28560399 3478 Rat rno-miR-485-5p miRNA complete freund's adjuvant (CFA) inflammatory pain L4-6 dorsal root ganglion (DRG) complete Freund's adjuvant (CFA) treatment The miRNA-485-5p expression level clearly decreased while the ASIC1 expression level was upregulated in the L4-6 dorsal root ganglion (DRG) of CFA rats. 33239909 3479 Rat rno-miR-486 miRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia induce downregulated 30121658 3480 Rat rno-miR-486 miRNA acute and long-term aerobic exercise cardiorespiratory fitness young men acute and long-term aerobic exercise treatment downregulated 27895662 3481 Rat rno-miR-486 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment upregulated 27910957 3482 Rat rno-miR-486 miRNA chronic hypoxia-hypercapnia (CHH) skeletal muscle atrophy gastrocnemius muscles chronic hypoxia-hypercapnia (CHH) treatment downregulated 30654931 3483 Rat rno-miR-486 miRNA neuromuscular electrical stimulation (NMES) skeletal muscle atrophy gastrocnemius muscles Neuromuscular Electrical Stimulation (NMES) treatment upregulated 30654931 3484 Rat rno-miR-486-3p miRNA high glucose (HG) diabetic retinopathy (DR) Muller cells high glucose (HG) treatment Bone marrow mesenchymal stem cells-induced exosomal microRNA-486-3p protects against diabetic retinopathy through TLR4/NF-¦ÊB axis repression. 32979189 3485 Rat rno-miR-486-5p miRNA hypoxia cyanotic congenital heart disease (CCHD) H9C2 cells hypoxia induce upregulated 31934081 3486 Rat rno-miR-487b miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment upregulated 27041227 3487 Rat rno-miR-487b-3p miRNA "2,5-hexanedione (HD)" "2,5-hexanedione (HD) toxicity" spinal cord tissues "2,5-hexanedione (HD) treatment" upregulated 31760062 3488 Rat rno-miR-488 miRNA psoralen osteogenesis bone marrow mesenchymal stem cells (BMSCs) psoralen treatment downregulated 31485621 3489 Rat rno-miR-489 miRNA gentamicin acute kidney injury (AKI) urine gentamicin treatment upregulated 27074385 3490 Rat rno-miR-489 miRNA resveratrol breast cancer matched tumor/normal tissues resveratrol (RS) treatment upregulated 24447120 3491 Rat rno-miR-489 miRNA H2O2 myocardial infarction (MI) H9c2 cells H2O2 treatment miR-489 expression was increased in H2O2-treated H9c2 cardiomyocytes 32880387 3492 Rat rno-miR-489 miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) induce upregulated 31378911 3493 Rat rno-miR-489-3p miRNA carbon tetrachloride (CCl4) liver fibrosis liver tissues carbon tetrachloride (CCl4) treatment miR-489-3p was significantly downregulated in liver fibrotic tissues compared with the control group. 32144602 3494 Rat rno-miR-490-3p miRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues lipopolysaccharide (LPS) treatment downregulated 33456519 3495 Rat rno-miR-490-3p miRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues lipopolysaccharide (LPS) treatment The results revealed that miR-490-3p was markedly downregulated in an LPS-induced rat ALI model 33456519 3496 Rat rno-miR-490-5p miRNA sevoflurane (SEV) brain injury rat middle cerebral artery occlusion model rats brain tissues Sevoflurane (SEV)??treatment treatment Sevo raised miR-490-5p and decreased CDK1 to improve neurological deficits 33513398 3497 Rat rno-miR-490-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3498 Rat rno-miR-490-5p miRNA dextran sodium sulfate (DSS) ulcerative colitis (UC) Sprague-Dawley (SD) rats colon tissues in the colon tissues dextran sulfate sodium (DSS) upregulated( miR-149-5p) downregulated (miR-184) in the colon tissues in the colon tissues 28246536 3499 Rat rno-miR-490-5p miRNA herb-partitioned moxibustion ulcerative colitis (UC) UC rats colon tissues herb-partitioned moxibustion downregulated 28246536 3500 Rat rno-miR-493 miRNA oxygen glucose deprivation (OGD) stroke rat brain microvascular endothelial cells (RBMECs) oxygen and glucose deprivation-induced treatment downregulated 26929185 3501 Rat rno-miR-493-3p miRNA chronic unpredictable mild stress (CUMS) depression hippocampus tissues chronic unpredictable mild stressed (CUMS) treatment upregulated 28083819 3502 Rat rno-miR-493-3p miRNA hronic unpredictable mild stressed (CUMS) depression rats hippocampal tissues stimulated daily with randomly applied mild stressors from among 14 different mild stressors upregulated 28083819 3503 Rat rno-miR-493-5p miRNA "2,5-hexanedione (HD)" "2,5-hexanedione (HD) toxicity" spinal cord tissues "2,5-hexanedione (HD) treatment" upregulated 31760062 3504 Rat rno-miR-494 miRNA hypoxia/reoxygenation (H/R) acute myocardial infarction (AMI) H9c2 cells hypoxia/reoxygenation (H/R) treatment downregulated 33174056 3505 Rat rno-miR-494 miRNA ethanol (EtOH) alcohol-induced anxiolysis Amygdaloid ethanol treatment downregulated 26786313 3506 Rat rno-miR-494 miRNA ethanol (EtOH) anxiolysis amygdaloid ethanol treatment downregulated 26786313 3507 Rat rno-miR-494 miRNA lithium chloride and pilocarpine epilepsy hippocampus lithium chloride-pilocarpine treatment downregulated 32308116 3508 Rat rno-miR-494 miRNA propofol (PPF) hepatic ischemia/reperfusion injury (HIRI) myocardial cell propofol treatment miR-494 levels were suppressed in the propofol group compared with the I/R group 33682507 3509 Rat rno-miR-494 miRNA atropine sulfate myocardial infarction (MI) rat heart tissues atropine sulfate treatment downregulated 31541797 3510 Rat rno-miR-494 miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) PC-12 cells lipopolysaccharide (LPS) treatment downregulated 30170481 3511 Rat rno-miR-494 miRNA lipopolysaccharide (LPS) spinal cord injury (SCI) Rat pheochomocytoma PC-12?cells lipopolysaccharide (LPS) treatment upregulated 30816451 3512 Rat rno-miR-494-3p miRNA ginsenoside Rg1 apoptosis hypoxia-induced male rat bone marrow mesenchymal stem cells (rBMSCs) Ginsenoside Rg1 treatment upregulated 29307726 3513 Rat rno-miR-494-3p miRNA hypoxia apoptosis Male rat bone marrow mesenchymal stem cells (rBMSCs) hypoxia induce downregulated 29307726 3514 Rat rno-miR-494-3p miRNA angiotensin II (Ang II) hypertensive nephropathy (HN) rat renal artery endothelial cells (RRAECs) angiotensin II (Ang II) treatment upregulated 32346437 3515 Rat rno-miR-494-3p miRNA Sera from patients with septic shock cardiomyocytes injury Rat cardiomyocytes (M6200) Sera from patients with septic shock treatment downregulated 30783439 3516 Rat rno-miR-495 miRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia induce MiR-495 expression was remarkably increased in H9c2 cells treated with hypoxia. 33506922 3517 Rat rno-miR-495 miRNA high glucose (HG) diabetic retinopathy (DR) retinal ganglion cells (RGCs) high glucose (HG) treatment miR-495 was significantly upregulated in HG-treated RGCs. 30119264 3518 Rat rno-miR-495 miRNA pilocarpine epilepsy hippocampus; hippocampal neurons pilocarpine treatment "The lncRNA UCA1 and Nrf2 were downregulated in epileptiform hippocampal tissues and neurons, while the miR-495 was upregulated" 29608952 3519 Rat rno-miR-495 miRNA repeated binge-EtOH exposure ethanol addiction dorsal and ventral hippocampus of male Wistar rats repeated binge-EtOH exposure treatment different regulation 24416161 3520 Rat rno-miR-495 miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment upregulated 27041227 3521 Rat rno-miR-495 miRNA ischemia periodontitis Serum Ligation around teeth treatment upregulated 26910654 3522 Rat rno-miR-495 miRNA monocrotaline (MCT) pulmonary arterial hypertension (PAH) PAH rats right ventricular (RV) tissues monocrotaline (MCT) treatment upregulated 29566365 3523 Rat rno-miR-495 miRNA artemisinin (ART) ventricular arrhythmias (VA) transverse aortic constriction (TAC) surgery treated rats left ventricle (LV) tissues artemisinin (ART) treatment upregulated 30595983 3524 Rat rno-miR-495-3p miRNA lipopolysaccharide (LPS) acute lung injury (ALI) Alveolar macrophages (NR8383) lipopolysaccharide (LPS) treatment "methylation of the miR-495 promoter could downregulate miR-495, whose elevation could attenuate the activation of the NLRP3 inflammasome to protect against ALI" 31734560 3525 Rat rno-miR-495-3p miRNA H2O2 myocardial ischemia/reperfusion (I/R) injury (MIRI) H9C2 cells H2O2 treatment downregulated 31347173 3526 Rat rno-miR-495-3p miRNA H2O2 myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells H2O2 treatment NEAT1 contributed to M-I/R injury via the modulation of miR-495-3p and MAPK6. 31347173 3527 Rat rno-miR-496 miRNA hypoxia cerebral ischemia/reperfusion (I/R) injury Middle cerebral middle cerebral artery occlusion/reperfusion (MCAO/R) induce downregulated 30597231 3528 Rat rno-miR-496 miRNA hypoxia/reoxygenation (H/R) myocardial infarction (MI) H92c cells hypoxia/reoxygenation (H/R) treatment miR-496 was lowly expressed in H/R-treated H9c2 cells. 31436348 3529 Rat rno-miR-496 miRNA hypoxia myocardial injury The H9c2 rat cardiomyocyte cells hypoxia induce "with Hook3 functionality's aid, miR-496 upregulation defends cells from H/R-induced apoptosis and stimulates cell proliferation." 31436348 3530 Rat rno-miR-496-3p miRNA methamphetamine (METH) addiction nucleus accumbens tissues Methamphetamine treatment dysregulated 28681200 3531 Rat rno-miR-497 miRNA angiotensin II (Ang II) cardiac hypertrophy Primary cardiomyocytes angiotensin II (Ang II) treatment Our data indicated that TUG1 was upregulated and miR-497 was downregulated in the TAC rat model and Ang II-induced cardiomyocytes. 33817315 3532 Rat rno-miR-497 miRNA bone matrix gelatin chondrogenesis chondrocytes bone matrix gelatin treatment downregulated 30156864 3533 Rat rno-miR-497 miRNA high glucose (HG) diabetic retinopathy (DR) M¨¹ller cells high glucose (HG) treatment miR-497 was significantly increased in high glucose-treated M¨¹ller cells 29383970 3534 Rat rno-miR-497 miRNA exercise training (ET) myocardial infarction (MI) heart sissues; serum exercise training (ET) ET reduced the infarct size in MI rats and inhibited the levels of miR-497. 32162294 3535 Rat rno-miR-497 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 3536 Rat rno-miR-497-5p miRNA "2,5-hexanedione (HD)" "2,5-hexanedione (HD) toxicity" spinal cord tissues "2,5-hexanedione (HD) treatment" downregulated 31760062 3537 Rat rno-miR-498 miRNA lipopolysaccharide (LPS) cell proliferation chondrocytes lipopolysaccharide (LPS) treatment downregulated 31141496 3538 Rat rno-miR-499 miRNA hypoxia/reoxygenation (H/R) acute myocardial infarction (AMI) human umbilical vein endothelial cells (HUVECs) hypoxia/reoxygenation (HX/R) treatment upregulated 31270949 3539 Rat rno-miR-499 miRNA mechanical stress apoptosis rat cardiomyocytes mechanical stress treatment downregulated 26859150 3540 Rat rno-miR-499 miRNA hypoxia/reoxygenation (H/R) cardiomyocytes injury H9c2 cells hypoxia/reoxygenation (H/R) induce downregulated 31076992 3541 Rat rno-miR-499 miRNA daunorubicin cardiomyopathy rats "daunorubicin (DAU-A, 3 mg/kg, every 48 h)" downregulated 28303410 3542 Rat rno-miR-499 miRNA losartan ischemia/reperfusion (I/R) injury heart tissues losartan treatment upregulated 26168042 3543 Rat rno-miR-499 miRNA myricetin myofiber type transition soleus and gastrocnemius muscles myricetin treatment upregulated 31073320 3544 Rat rno-miR-499 miRNA lipopolysaccharide (LPS) sepsis cardiomyocytes lipopolysaccharide (LPS) treatment upregulated 26659076 3545 Rat rno-miR-499-5p miRNA isoproterenol acute cardiac injury heart tissues isoproterenol treatment upregulated 27605421 3546 Rat rno-miR-499-5p miRNA hyperoxia acute myocardial infarction (AMI) neonatal rat cardiomyocytes hyperoxia treatment upregulated 27231854 3547 Rat rno-miR-499-5p miRNA hypoxia hypoxic-ischemic encephalopathy (HIE) neonatal rats brain tissues hypoxia induce downregulated 31812653 3548 Rat rno-miR-499-5p miRNA notexin skeletal muscle atrophy plasma notexin treatment upregulated 26952641 3549 Rat rno-miR-499a-5p miRNA doxorubicin (DOX) cardiotoxicity left ventricular samples Doxorubicin (DOX) treatment upregulated 31048226 3550 Rat rno-miR-499a-5p miRNA high-intensity interval training (HIIT) cardiotoxicity DOX-induced rats left ventricular samples high-intensity interval training (HIIT) treatment downregulated 31048226 3551 Rat rno-miR-499a-5p miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia induce downregulated 31452254 3552 Rat rno-miR-500 miRNA ischemia chronic constriction injury rat spinal cord ligation of the sciatic nerve treatment "The expression levels of a large number of miRNAs in the dorsal horn of the spinal cord in CCI rats changed (miR-500, -221 and -21)" 23124577 3553 Rat rno-miR-500-3p miRNA huoxue jiedu formula (HXJDF) diabetic retinopathy (DR) retinal tissues HuoXue JieDu Formula (HXJDF) treatment miR-500-3p was downregulated in HuoXue JieDu Formula (HXJDF) treated group when compared with diabetic mice. 33271246 3554 Rat rno-miR-503 miRNA hypoxia apoptosis H9c2 rat myocardial cells hypoxia induce upregulated 30404731 3555 Rat rno-miR-503 miRNA azoxymethane (AOM) colorectal cancer (CRC) colonic tissue of rat azoxymethane (AOM) treatment downregulated 23049818 3556 Rat rno-miR-503 miRNA high glucose (HG) diabetic peripheral neuropathy (DPN) RSC96 cells high glucose (HG) treatment upregulated 31581849 3557 Rat rno-miR-503 miRNA notoginsenoside R1 (NGR1) diabetic peripheral neuropathy (DPN) high glucose-treated RSC96 cells Notoginsenoside R1 (NGR1) treatment downregulated 31581849 3558 Rat rno-miR-503 miRNA adreno-cortico-tropic-hormone (ACTH) hormonal regulation adrenals?tissues adreno-cortico-tropic-hormone (ACTH) treatment downregulated 24205079 3559 Rat rno-miR-503 miRNA estradiol-17¦Â (E2) hormonal regulation adrenals?tissues estradiol-17¦Â (E2) treatment downregulated 24205079 3560 Rat rno-miR-503-5p miRNA mechanical stretch bone formation RBMSCs Flexcell FX-5000TM Tension System downregulated 27862699 3561 Rat rno-miR-503-5p miRNA cyclic mechanical stretch (CMS) orthodontic bone mesenchymal stem cells (BMSCs) Cyclical stretch treatment downregulated 27862699 3562 Rat rno-miR-503-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3563 Rat rno-miR-506 miRNA free fatty acids (FFA) nonalcoholic fatty liver disease (NAFLD) BRL3A cell free fatty acid (FFA) treatment downregulated 31957704 3564 Rat rno-miR-506 miRNA lipopolysaccharide (LPS) pulpitis dental pulp stem cells (DPSCs) lipopolysaccharide (LPS) treatment upregulated 31877121 3565 Rat rno-miR-511 miRNA dexamethasone (DEX) depression prefrontal cortex of adolescent rats dexamethasone (DEX) treatment downregulated 30469088 3566 Rat rno-miR-511 miRNA dexamethasone (DEX) depression prefrontal cortex of adult rats dexamethasone (DEX) treatment downregulated 30469088 3567 Rat rno-miR-511-3p miRNA monocrotaline (MCT) sinusoidal obstruction syndrome plasma monocrotaline treatment upregulated 29353062 3568 Rat rno-miR-519d-3p miRNA hypoxia myocardial infarction (MI) rat heart tissues permanent ligation of the left anterior descending (LAD) coronary artery induce upregulated 30607799 3569 Rat rno-miR-520a miRNA hypoxia cardiomyocyte apoptosis H9c2 cardiomyocyte cell line hypoxia induce downregulated 31410172 3570 Rat rno-miR-525-5p miRNA oxygen glucose deprivation (OGD) brain injury neurons oxygen-glucose deprivation (OGD) treatment downregulated 26770408 3571 Rat rno-miR-525-5p miRNA hypoxia myocardial infarction (MI) myocardial cell line H9c2 hypoxia induce downregulated 31429119 3572 Rat rno-miR-532 miRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) Wistar rats left ventricle (LV) STZ treatment upregulated 28199183 3573 Rat rno-miR-532-3p miRNA insert a cannula connected with a saline container into the anterior chamber acute ocular hypertension (AOH) adult albino rats retinal ganglion cells (RGCs) and microglial cells insert a cannula connected with a saline container into the anterior chamber upregulated 27535721 3574 Rat rno-miR-532-3p miRNA estrogen (ES) postmenopausal osteoporosis (PMOP) bone tissues estrogen treatment downregulated 33577975 3575 Rat rno-miR-532-5p miRNA parathyroid hormone (PTH) bone remodeling rat osteoblasts Parathyroid hormone (PTH) treatment downregulated 29626351 3576 Rat rno-miR-532-5p miRNA hypoxia cardiomyocytes injury H9c2 cells hypoxia treatment miR-532-5p was downregulated in hypoxia-exposed H9c2 cells. 29958954 3577 Rat rno-miR-532-5p miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment downregulated 27041227 3578 Rat rno-miR-532-5p miRNA anoxia/reoxygenation (A/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells anoxia/reoxygenation (A/R) treatment downregulated 31985016 3579 Rat rno-miR-532-5p miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) treatment TUG1 silence ameliorated H/R-induced cardiomyocytes injury through regulating miR-532-5p/Sox8 axis. 32833900 3580 Rat rno-miR-532-5p miRNA bortezomib peripheral neuropathy PC12 cells bortezomib treatment downregulated 31979371 3581 Rat rno-miR-539 miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) cerebral ischemia/reperfusion (I/R) injury The rat microvascular endothelial cell line bEND.3 oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 30276507 3582 Rat rno-miR-539 miRNA chronic constriction injury (CCI) neuronal mechanisms Sprague-Dawley rats anterior cingulate cortex (ACC) chronic constriction injury (CCI) induce downregulated 28379535 3583 Rat rno-miR-539-5p miRNA insert a cannula connected with a saline container into the anterior chamber acute ocular hypertension (AOH) adult albino rats retinal ganglion cells (RGCs) and microglial cells insert a cannula connected with a saline container into the anterior chamber downregulated 27535721 3584 Rat rno-miR-539-5p miRNA bushen huoxue decoction (BHD) bone fractures rat mesenchymal stem cells (rMSCs) bushen huoxue decoction (BHD) treatment downregulated 31341413 3585 Rat rno-miR-539-5p miRNA laser photocoagulation experimental choroidal neovascularization retinal pigment epithelial/choroid/sclera tissues of laser-injured eyes laser photocoagulation treatment downregulated 29146732 3586 Rat rno-miR-541 miRNA SiO2 lung injury lung SiO2 treatment downregulated 27689473 3587 Rat rno-miR-541-5p miRNA TGF-¦Â idiopathic pulmonary fibrosis (IPF) pulmonary fibrosis rats treat with TGF-¦Â treatment downregulated 28816543 3588 Rat rno-miR-542-3p miRNA Yiqifumai Injection (YQFM) chronic heart failure (CHF) H9c2 cells Yiqifumai Injection (YQFM) treatment upregulated 29467665 3589 Rat rno-miR-542-3p miRNA kainic acid (KA) epilepsy hippocampal tissues kainic acid (KA) treatment downregulated 31702493 3590 Rat rno-miR-542-3p miRNA light focal retinal degeneration right eye light treatment upregulated 25921151 3591 Rat rno-miR-542-3p miRNA TGF-¦Â1 liver fibrosis HSC©\T6 cells transforming growth factor ¦Â1 (TGF¦Â1) treatment upregulated 30368874 3592 Rat rno-miR-542-5p miRNA hypoxia/reoxygenation (H/R) hypoxia/reoxygenation (H/R) injury H9c2 cells hypoxia/reoxygenation (H/R) treatment we found that the miR-542-5p expression and the autophagy activation were significantly increased in H9c2 cells after H/R injury. 33394350 3593 Rat rno-miR-543 miRNA angiotensin II (Ang II) cardiac fibrosis cardiac fibroblasts angiotensin II (Ang II) treatment RNF7 promotes the cardiac fibrosis in rat model via miR-543/THBS1 axis and TGF¦Â1 activation. 31913855 3594 Rat rno-miR-547* miRNA "3,3'-iminodipropionitrile (IDPN)" neurotoxicity pons and medulla "3,3'-iminodipropionitrile (IDPN) treatment" upregulated 27821907 3595 Rat rno-miR-547-3p miRNA methamphetamine (METH) methamphetamine (METH) addiction brain tissues Methamphetamine (METH) treatment upregulated 32893733 3596 Rat rno-miR-547-3p miRNA Jianpi Xiaoke (JPXK) type 2 diabetes mellitus (T2DM) rat Jianpi Xiaoke (JPXK) treatment upregulated 33456489 3597 Rat rno-miR-551b miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment downregulated 27041227 3598 Rat rno-miR-551b-5p miRNA high glucose (HG) diabetic cardiomyopathy (DCM) neonatal rats cardiomyocytes high glucose (HG) treatment "DCRF can act as a competing endogenous RNA to increase PCDH17 expression by sponging miR-551b-5p, thus contributing to increased cardiomyocyte autophagy in DCM." 31285779 3599 Rat rno-miR-551b-5p miRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) rat heart tissues streptozotocin treatment "DCRF can act as a competing endogenous RNA to increase PCDH17 expression by sponging miR-551b-5p, thus contributing to increased cardiomyocyte autophagy in DCM" 31285779 3600 Rat rno-miR-558 miRNA isoproterenol myocardial infarction (MI) rat H9C2 cells isoproterenol (ISO) treatment lncRNA MALAT1 protected cardiomyocytes from ISO-induced apoptosis by sponging miR-558 thus promoting ULK1-dependent autophagy. 30536615 3601 Rat rno-miR-558 miRNA CoCl2 spinal cord injury (SCI) PC12 cells CoCl2 treatment circ-HIPK3 relieves the neuronal cell apoptosis through regulating miR-588/DPYSL5 axis in SCI. 32247616 3602 Rat rno-miR-582-5p miRNA propofol (PPF) propofol-induced neurotoxicity primary rat hippocampal neurons Propofol treatment miR-582-5p were decreased in a time-dependent manner after propofol treatment 32031069 3603 Rat rno-miR-590 miRNA ferulic acid (FA) spinal cord injury (SCI) neural stem cells (NSCs) of SCI rat FA downregulated 28642684 3604 Rat rno-miR-590-3p miRNA hypoxia/reoxygenation (H/R) acute myocardial infarction (AMI) H9c2 cells hypoxia/reoxygenation (H/R) treatment "ZFAS1 was upregulated in H9c2 cells subjected to I/R injury, and that ZFAS1 knockdown protected against I/R-induced myocardial cell apoptosis by directly interacting with miR-590-3p, via the NF-¦ÊB pathway." 32705215 3605 Rat rno-miR-590-3p miRNA nuclear factor kappa-B (NF-¦ÊB) myocarditis and heart dysfunction heart tissues NF-¦ÊB treatment downregulated 26278103 3606 Rat rno-miR-590-3p miRNA lipopolysaccharide (LPS) sepsis H9c2 cells lipopolysaccharide (LPS) treatment lncRNA NEAT1 accelerated apoptosis and inflammation in LPS-stimulated H9c2 cells via sponging miR-590-3p. 32855700 3607 Rat rno-miR-592 miRNA amyloid-¦Â (A¦Â) 25-35 Alzheimer's disease (AD) astrocytes (ASTs) from AD rats amyloid-¦Â (A¦Â) 25-35 treatment upregulated 31759899 3608 Rat rno-miR-592 miRNA D-galactose (D-Gal) Alzheimer's disease (AD) astrocytes (ASTs) from AD rats D-galactose treatment upregulated 31759899 3609 Rat rno-miR-592 miRNA amyloid-¦Â (A¦Â) 25-35 Alzheimer's disease (AD) hippocampus tissues amyloid-¦Â (A¦Â) 25-35 treatment upregulated 31759899 3610 Rat rno-miR-593-5p miRNA hypoxia hypoxic pulmonary hypertension (HPH) lung tissues and pulmonary arterial smooth muscle cells (PASMCs) hypoxia induce downregulated 31081105 3611 Rat rno-miR-612 miRNA platelet derived growth factor-BB (PDGF-BB) atherosclerosis (AS) VSMCs isolated from the thoracic aortas of rat platelet-derived growth factor-BB (PDGF-BB) treatment downregulated 29399059 3612 Rat rno-miR-612 miRNA dexamethasone (DEX) cartilage injury articular cartilage dexamethasone (DEX) treatment miR-612 was downregulated compared with control group. 29207029 3613 Rat rno-miR-612 miRNA platelet derived growth factor-BB (PDGF-BB) neointimal formation vascular smooth muscle cells (VSMCs) platelet-derived growth factor (PDGF)-BB treatment "PDGF-BB significantly promoted the proliferation and migration of VSMCs, and decreased miR-612 levels in VSMCs" 29399059 3614 Rat rno-miR-6215 miRNA doxorubicin (DOX) ischemia/reperfusion (I/R) injury rats cardiomyocytes doxorubicin treatment downregulated 27919821 3615 Rat rno-miR-6216 miRNA doxorubicin (DOX) ischemia/reperfusion (I/R) injury rats cardiomyocytes doxorubicin treatment upregulated 27919821 3616 Rat rno-miR-6216 miRNA doxorubicin (DOX) renal interstitial fibrosis (RIF) kidneys doxorubicin (ADR) induction upregulated 32606425 3617 Rat rno-miR-6216 miRNA "kangxianling (KXL, anti-fibrin)" renal interstitial fibrosis (RIF) kidneys "Kangxianling (KXL, anti-fibrin) treatment" downregulated 32606425 3618 Rat rno-miR-628 miRNA insert a cannula connected with a saline container into the anterior chamber acute ocular hypertension (AOH) adult albino rats retinal ganglion cells (RGCs) and microglial cells insert a cannula connected with a saline container into the anterior chamber downregulated 27535721 3619 Rat rno-miR-628 miRNA burn injury burn-induced skeletal muscle atrophy rats burn treatment upregulated 27766036 3620 Rat rno-mir-6314 miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3621 Rat rno-miR-6322 miRNA ischemia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells ischemia buffer treatment Hsa-circ-0068566 inhibited the development of myocardial ischemia reperfusion injury by regulating hsa-miR-6322/PARP2 signal pathway. 32633392 3622 Rat rno-miR-6324 miRNA tunicamycin (TM) endoplasmic reticulum stress (ERS) H9c2 cells tunicamycin treatment lncRNA Dancr overexpression protected cardiomyocytes against ERS injury via sponging miR-6324. 33300079 3623 Rat rno-mir-6329 miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3624 Rat rno-miR-636 miRNA caffeic acid diabetic nephropathy (DN) liver tissues caffeic acid (CA) treatment caffeic acid down regulates miR-636 expression level. 31391719 3625 Rat rno-miR-636 miRNA caffeic acid diabetic nephropathy (DN) kidney tissues caffeic acid (CA) treatment downregulated 31391719 3626 Rat rno-miR-636 miRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissues streptozotocin treatment upregulated 31391719 3627 Rat rno-miR-638 miRNA resveratrol pulmonary arterial hypertension (PAH) rat pulmonary arterial smooth muscle cells (PASMCs) resveratrol (RS) treatment "MCT resulted in significant pulmonary vascular remodeling and downregulated of miR-638, which could be suppressed by resveratrol" 32057731 3628 Rat rno-miR-652 miRNA oxygen glucose deprivation (OGD) ischemic brain injury PC12 cells; brain tissues oxygen-glucose deprivation (OGD treatment "The transcription factor NR4A2 mediates the expression of Mul1 through transcriptional repression of miR-652, thus promoting ischemic brain injury" 33116527 3629 Rat rno-miR-652-3p miRNA valproic acid (VPA) cell differentiation primary cultured neural stem cells (NSCs) valproate (VPA) treatment upregulated 29575035 3630 Rat rno-miR-652-3p miRNA huoxue jiedu formula (HXJDF) diabetic retinopathy (DR) retinal tissues HuoXue JieDu Formula (HXJDF) treatment miR-652-3p was upregulated in HuoXue JieDu Formula (HXJDF) treated group when compared with control mice. 33271246 3631 Rat rno-miR-652-5p miRNA steroids osteonecrosis bone marrow mesenchymal stem cells (BMSCs) steroid treatment upregulated 26459755 3632 Rat rno-miR-659-3p miRNA hypoxia familial frontotemporal lobar degeneration (FTLD) ?rat cortices Hypoxia treatment downregulated 27199656 3633 Rat rno-miR-663b miRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia treatment miR-663b inhibition protected cardiomyocytes against hypoxia-induced injury by targeting BCL2L1. 32346421 3634 Rat rno-miR-664 miRNA acarbose diabetes mellitus (DM) blood acarbose? treatment upregulated 24260283 3635 Rat rno-miR-664-2 miRNA danazol precocious puberty (PP) rat hypothalamus tissues Danazol treatment downregulated 30916745 3636 Rat rno-miR-665 miRNA propofol (PPF) central nervous system (CNS) development astroglia propofol treatment downregulated 26083276 3637 Rat rno-miR-665 miRNA hypoxia/reoxygenation (H/R) myocardial infarction (MI) H9c2 cells hypoxia/reoxygenation (H/R) treatment upregulated 32132320 3638 Rat rno-miR-666-3p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) inflammation primary brain microvascular endothelial cells (BMECs) oxygen-glucose deprivation and reoxygenation (OGD/R) treatment "?In particular, the expression levels of rno-miR-666-3p, rno-miR-92a-2-5p, and rno-miR-219a-2-3p decreased in OGD/R-exposed cells compared with those in the control" 33745435 3639 Rat rno-miR-668 miRNA hypoxia acute kidney injury (AKI) rat proximal tubular cells (RPTC) hypoxia induce upregulated 30325740 3640 Rat rno-miR-668 miRNA erythropoietin (EPO) hydrocephalus kaolin-induced obstructive hydrocephalus rats periventricular ependymal lining and cultured astrocytes erythropoietin (EPO) treatment downregulated 29982881 3641 Rat rno-miR-668 miRNA kaolin hydrocephalus periventricular ependymal lining and cultured astrocytes kaolin treatment upregulated 29982881 3642 Rat rno-miR-671 miRNA 1-methyl-4-phenylpyridinium (MPP+) parkinson's disease (PD) PC12 cells 1-methyl-4-phenylpyridinium (MPP+) treatment downregulated 32889692 3643 Rat rno-miR-671 miRNA exendin-4 (Ex-4) parkinson's disease (PD) 1-methyl-4-phenylpyridinium (MPP+)-treated PC12 cells Exendin-4 (Ex-4)?treatment upregulated 32889692 3644 Rat rno-miR-671 miRNA exendin-4 (Ex-4) neuronal cell injury PC12 cells Exendin-4 (Ex-4) treatment Ex-4 downregulated 1-methyl-4 phenyl-pyridine ion (MPP+) -induced CDR1as expression in PC12 cells and upregulated miR-671 expression. 32889692 3645 Rat rno-miR-672 miRNA angiotensin II (Ang II) cardiac hypertrophy primary cultured rat cardiomyocytes angiotensin II (Ang II) treatment downregulated 29339068 3646 Rat rno-miR-672 miRNA insulin-like growth factor 1 (IGF-1) cardiac hypertrophy primary cultured rat cardiomyocytes insulin-like growth factor 1 treatment downregulated 29339068 3647 Rat rno-miR-672 miRNA phenylephrine (PE) cardiac hypertrophy primary cultured rat cardiomyocytes phenylephrine treatment downregulated 29339068 3648 Rat rno-miR-672 miRNA perfluorooctane sulfonic acid (PFOS) neural dysfunctions rat brains perfluorooctane sulfonic acid (PFOS) treatment downregulated 22594572 3649 Rat rno-miR-672-5p miRNA steroids osteonecrosis osteoblasts steroid treatment upregulated 27378744 3650 Rat rno-miR-674-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3651 Rat rno-miR-674-3p miRNA insulin-like growth factor 1 (IGF-1) spinal cord injury (SCI) Neural stem cells were obtained from E15 fetal rat cerebral cortex cultured supernatant exosomes insulin growth factor-1 (IFG-1) treatment upregulated 31848325 3652 Rat rno-miR-674-5p miRNA valproic acid (VPA) cell differentiation primary cultured neural stem cells (NSCs) valproate (VPA) treatment upregulated 29575035 3653 Rat rno-miR-675 miRNA H2O2 aging-induced vascular dysfunction H9C2 cells H2O2 treatment downregulated 30889706 3654 Rat rno-miR-675 miRNA adriamycin (ADR) dilated cardiomyopathy (DCM) rats?myocardial tissue adriamycin (ADR) treatment downregulated 28430627 3655 Rat rno-miR-676 miRNA bleomycin (BLM) lung fibrosis lung tissues bleomycin (BLM) treatment upregulated 33193637 3656 Rat rno-mir-676 miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3657 Rat rno-miR-676-1 miRNA fastigial nucleus stimulation (FNS) focal cerebral ischemia rat brain fastigial nucleus stimulation (FNS)?treatment upregulated 25783478 3658 Rat rno-miR-680 miRNA corticotrophin releasing factor (CRF) receptor I antagonist (BMS-764459) hepatocellular carcinoma (HCC) rat liver cells "The corticotrophin releasing factor (CRF) receptor I antagonist, BMS-764459 treatment" "MiR-680 and miR-29a were identified as potential regulators and biomarkers of atypical CYP1A1 induction by regulating Abcc3, CYP3A and CYP2B as well as a number of AhR targeted genes" 23831372 3659 Rat rno-miR-682 miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H92c cells hypoxia/reoxygenation treatment downregulated 32590403 3660 Rat rno-miR-691 miRNA nerve growth factor (Ngf) neurodegenerative diseases PC12 cells 100 ng/ml Ngf treatment different regulation 24492999 3661 Rat rno-miR-7 miRNA streptozocin (STZ) diabetic retinopathy (DR) primary isolated endothelial cell (EC) and retinal pericyte (RP) streptozotocin (STZ) treatment downregulated 30058674 3662 Rat rno-miR-7 miRNA tricin glioblastoma multiforme (GBM) C6 glioma cells tricin treatment upregulated 29877083 3663 Rat rno-miR-7 miRNA hypoxia ischemic stroke (IS) hippocampal CA1 neurons hypoxia induce upregulated 30305621 3664 Rat rno-miR-7 miRNA atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine; ATR) parkinson's disease (PD) peripheral blood and brain tissue in a rat model of PD Atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine; ATR) treatment miR-7 was upregulated in brain tissue but downregulated in peripheral blood of rats with ATR-induced PD. 31185338 3665 Rat rno-miR-7 miRNA rotenone (ROT) parkinson's disease (PD) striatum of parkinsonian rats rotenone exposure treatment upregulated 30267378 3666 Rat rno-miR-7 miRNA crocin parkinson's disease (PD) striatal tissueS crocin treatment Crocin upregulated the expression of miRNA-7. 31811872 3667 Rat rno-miR-702-3p miRNA SiO2 lung injury lung SiO2 treatment upregulated 27689473 3668 Rat rno-miR-702-3p miRNA propofol (PPF) neural function left cortex of the brain Propofol treatment significantly increased 26021509 3669 Rat rno-miR-706 miRNA palmitate and palmitate plus oleate. insulin resistance (IR) mouse myoblasts palmitate and palmitate plus oleate treatment upregulated 21183973 3670 Rat rno-miR-708 miRNA ¦Â-ionone (¦ÂI) hepatocellular carcinoma (HCC) rats hepatocyte ¦ÂI (16 mg/100 g body weight) treatment "upregulated(miR-122 , miR-34a) ;downregulated (miR-181b , miR-708)" 27061051 3671 Rat rno-miR-708-3p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3672 Rat rno-miR-708-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3673 Rat rno-miR-708-5p miRNA nickel steroidogenesis disturbance Leydig cells NiSO4 induce dysregulated 31734292 3674 Rat rno-miR-708-5p miRNA NiSO4 steroidogenesis disturbance rat Leydig cells NiSO4 treatment upregulated 31948324 3675 Rat rno-miR-709 miRNA acetaminophen (APAP) and methapyrilene (MP) liver damage rats pericentral and periportal regions acetaminophen (APAP) and methapyrilene (MP) treatment upregulated 24863736 3676 Rat rno-miR-709 miRNA nerve growth factor (Ngf) neurodegenerative diseases PC12 cells 100 ng/ml Ngf treatment different regulation 24492999 3677 Rat rno-miR-71 miRNA "hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)" neurotoxicity brain tissues of rats RDX at a dose(47 mg/kg) for 48 h treatment upregulated 25559034 3678 Rat rno-miR-7-1 miRNA "1,3,5-tris-4-propyl-1H-pyrazole" spinal cord injury (SCI) VSC4.1 motoneurons ER agonists treatment upregulated 24157932 3679 Rat rno-miR-711 miRNA palmitate and palmitate plus oleate. insulin resistance (IR) mouse myoblasts palmitate and palmitate plus oleate treatment upregulated 21183973 3680 Rat rno-miR-711 miRNA pioglitazone myocardial infarction (MI) rat cardiac fibroblasts pioglitazone treatment upregulated 23633075 3681 Rat rno-miR-711 miRNA antimycin A (AA) oxidative stress H9c2 cells antimycin A (AA) treatment upregulated 32308692 3682 Rat rno-miR-711 miRNA CoCl2 oxidative stress H9c2 cells CoCl2 treatment upregulated 32308692 3683 Rat rno-miR-711 miRNA H2O2 oxidative stress H9c2 cells H2O2 treatment upregulated 32308692 3684 Rat rno-miR-711 miRNA hypoxia/reoxygenation (H/R) oxidative stress H9c2 cells hypoxia/reoxygenation (H/R)) treatment upregulated 32308692 3685 Rat rno-miR-711 miRNA etoposide (VP-16) spinal cord injury (SCI) primary cultured cortical neurons etoposide treatment upregulated 31685802 3686 Rat rno-miR-711 miRNA staurosporine spinal cord injury (SCI) primary cultured cortical neurons staurosporine treatment upregulated 31685802 3687 Rat rno-miR-7134-5p miRNA artemisinin (ART) ventricular arrhythmias (VA) transverse aortic constriction (TAC) surgery treated rats left ventricle (LV) tissues artemisinin (ART) treatment upregulated 30595983 3688 Rat rno-miR-714 miRNA dexamethasone (DEX) cartilage injury articular cartilage dexamethasone (DEX) treatment miR-714was downregulated compared with control group. 29207029 3689 Rat rno-miR-720 miRNA acetaminophen (APAP) and methapyrilene (MP) liver damage rats pericentral and periportal regions acetaminophen (APAP) and methapyrilene (MP) treatment upregulated 24863736 3690 Rat rno-miR-743b-5p miRNA artemisinin (ART) ventricular arrhythmias (VA) transverse aortic constriction (TAC) surgery treated rats left ventricle (LV) tissues artemisinin (ART) treatment upregulated 30595983 3691 Rat rno-miR-7-5p miRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia induce downregulated 31264206 3692 Rat rno-miR-7-5p miRNA hypoxia acute myocardial infarction (AMI) H9c2 cells hypoxia treatment ANRIL plays a protective part in hypoxia-induced H9c2 cell injury via modulating the miR-7-5p/SIRT1 axis 31264206 3693 Rat rno-miR-7-5p miRNA icariside II (ICA II) hypoxia-induced injury H9c2 cells Icariside II (ICS II) treatment upregulated 32945347 3694 Rat rno-miR-7-5p miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) rat H9C2 cells hypoxia induce downregulated of MEG3 protects myocardial cells against I/R-induced apoptosis through miR-7-5p/PARP1 pathway 31366567 3695 Rat rno-miR-760 miRNA verapamil male fertility testis verapamil treatment downregulated 32725937 3696 Rat rno-miR-760 miRNA hypoxia/reoxygenation (H/R) myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia/reoxygenation (H/R) treatment miR-760 was downregulated in H9C2 cells exposed to H/R. 32160475 3697 Rat rno-miR-760-3p miRNA nickel steroidogenesis disturbance Leydig cells NiSO4 induce dysregulated 31734292 3698 Rat rno-miR-760-3p miRNA NiSO4 steroidogenesis disturbance rat Leydig cells NiSO4 treatment downregulated 31948324 3699 Rat rno-miR-760-5p miRNA guarana adipogenesis 3T3L1 cells guarana downregulated 28632199 3700 Rat rno-miR-764 miRNA hypoxia/reoxygenation (H/R) acute myocardial infarction (AMI) H9c2 cells hypoxia/reoxygenation (H/R) treatment downregulated 33199822 3701 Rat rno-miR-764 miRNA hypoxia/reoxygenation (H/R) acute myocardial infarction (AMI) H9c2 cells hypoxia reoxygenation (H/R) treatment Mirt2 participated in the regulation of MI through the miR-764/PDK1 axis. 33199822 3702 Rat rno-miR-764-5p miRNA high fat diet (HFD) cardiac remodeling heart tissues high fat diet (HFD) feed upregulated 29884823 3703 Rat rno-miR-766-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) PC12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 33791020 3704 Rat rno-miR-7a miRNA dexamethasone (DEX) cartilage injury articular cartilage dexamethasone (DEX) treatment miR-7a was downregulated compared with control group. 29207029 3705 Rat rno-miR-7a miRNA palmitate and palmitate plus oleate. insulin resistance (IR) mouse myoblasts palmitate and palmitate plus oleate treatment upregulated 21183973 3706 Rat rno-miR-7a-5p miRNA hypoxia hypoxic/ischemic injury Male Sprague Dawley rats "were exposed to hypoxia (9.5-10% O2) for 1, 5, or 10 days" upregulated 29262398 3707 Rat rno-miR-7a-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3708 Rat rno-miR-7a-5p miRNA recurrent insulin-induced hypoglycemia (RH) sympathoadrenal response ventromedial hypothalamus (VMH) recurrent insulin-induced hypoglycemia (RH) treatment downregulated 31619588 3709 Rat rno-miR-7b miRNA hypoxia acute myocardial infarction (AMI) rat cardiomyoblast cells (H9c2) hypoxia induce downregulated 30548297 3710 Rat rno-miR-7b miRNA ischemia chronic heart failure (CHF) Plasma Ligation of the left anterior descendent coronary artery treatment upregulated 26699387 3711 Rat rno-miR-7b miRNA hypoxia ischemia/reperfusion (I/R) injury H9C2 cells hypoxia induce downregulated 30548297 3712 Rat rno-miR-7b miRNA electroacupuncture (EA) spinal cord injury (SCI) spinal cords electroacupuncture (EA) treatment downregulated 32468009 3713 Rat rno-miR-7c miRNA hypoxia myocardial ischaemic injury neonatal rat ventricular myocytes hypoxia treatment downregulated 26655604 3714 Rat rno-miR-7g miRNA hypoxia myocardial ischaemic injury neonatal rat ventricular myocytes hypoxia treatment downregulated 26655604 3715 Rat rno-miR-802 miRNA palmitate type 2 diabetes mellitus (T2DM) INS-1 rat insulinoma cell line palmitate for 48 h treatment upregulated 31966484 3716 Rat rno-miR-871-3p miRNA high fat diet (HFD) aging-related non-alcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD) feed upregulated 31899128 3717 Rat rno-miR-873 miRNA hypoxia myocardial ischemia/reperfusion (I/R) injury (MIRI) H9c2 cells hypoxia induce downregulated 31570671 3718 Rat rno-miR-873-5p miRNA amyloid-¦Â (A¦Â) 1-42 Alzheimer's disease (AD) PC12 cells amyloid ¦Â1-42?(A¦Â) treatment downregulated 29926354 3719 Rat rno-miR-873-5p miRNA ginsenoside Rg1 (GRg1) and acori graminei Rhizoma (AGR) Alzheimer's disease (AD) A¦Â1-42-treated PC12 cells Ginsenoside Rg1 (GRg1)/Acori graminei Rhizoma (AGR) treatment upregulated 29926354 3720 Rat rno-miR-874 miRNA streptozocin (STZ) diabetic nephropathy (DN) kidney tissues streptozotocin (STZ) treatment downregulated 30171701 3721 Rat rno-miR-874-3p miRNA streptozocin (STZ) diabetes mellitus-induced erectile dysfunction (DMED) Rat cavernosum tissues streptozocin treatment downregulated 31914690 3722 Rat rno-miR-874-3p miRNA streptozocin (STZ) diabetes mellitus-induced erectile dysfunction (DMED) cavernosum tissues streptozotocin (STZ) treatment Epigenetic silencing of microRNA-874-3p implicates in erectile dysfunction in diabetic rats by activating the Nupr1/Chop-mediated pathway 31914690 3723 Rat rno-miR-874-3p miRNA ischemia/reperfusion (I/R) ischemia/reperfusion (I/R) injury PC12 cells ischemia/reperfusion (I/R) treatment LncRNA NEAT1 aggravates cerebral I/R injury by suppressing miR-874-3p expression. 32329323 3724 Rat rno-miR-874-3p miRNA hypoxia ischemic stroke (IS) brain tissues middle cerebral artery occlusion/reperfusion (MCAO/R) treatment downregulated 31200256 3725 Rat rno-miR-874-5p miRNA hypoxia autophagy Pulmonary artery smooth muscle cells (PASMCs) hypoxia treatment miR-874-5p was upregulated following hypoxia. 32805255 3726 Rat rno-miR-875-3p miRNA doxorubicin (DOX) cardiotoxicity H9c2 cells Doxorubicin (DOX) treatment Knockdown of miRNA-875-3p decreased the proliferative ability of cardiomyocytes. 32010313 3727 Rat rno-miR-875-3p miRNA doxorubicin (DOX) doxorubicin (DOX)-induced cardiotoxicity H9c2 cells doxorubicin (DOX) treatment downregulated 32010313 3728 Rat rno-miR-877 miRNA streptozocin (STZ) diabetic cardiomyopathy (DCM) Wistar rats left ventricle (LV) STZ treatment downregulated 28199183 3729 Rat rno-mir-877 miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3730 Rat rno-miR-881-3p miRNA high fat diet (HFD) aging-related non-alcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD) feed upregulated 31899128 3731 Rat rno-miR-9 miRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues endotoxin treatment upregulated 26137246 3732 Rat rno-miR-9 miRNA epigallocatechin-3-gallate (EGCG) chronic kidney disease (CKD) NRK-49F cells EGCG treatment EGCG upregulated the Expression of MiR-9. 30468495 3733 Rat rno-miR-9 miRNA hypoxia congenital heart disease (CHD) H9c2 cells hypoxia induce upregulated 30639391 3734 Rat rno-miR-9 miRNA occlusion of the bilateral common carotid artery (2VO) "dementia ,learning and memory" hippocampus; cortex occlusion of the bilateral common carotid artery (2VO) treatment upregulated in both the hippocampus and cortex 28683457 3735 Rat rno-miR-9 miRNA emodin diabetic foot ulcer (DFU) PC-12 cells emodin treatment miR-9 was highly expressed in response to emodin treatment. 29577942 3736 Rat rno-miR-9 miRNA high glucose (HG) diabetic cardiomyopathy (DCM) H9C2 cells high glucose treatment downregulated 26898797 3737 Rat rno-miR-9 miRNA alcohol fetal alcohol exposure (FAE) pregnant Fisher 344 rats pituitary liquid diet containing 6.7% alcohol between gestational days 7-21 (AF) upregulated 28710248 3738 Rat rno-miR-9 miRNA serum hepatopulmonary syndrome (HPS) pulmonary artery smooth muscle cell (PASMC) serum treatment upregulated 26147104 3739 Rat rno-miR-9 miRNA hypoxia hypoxia-induced cardiac dysfunctions H9c2 cells hypoxia treatment "We found that miR-9 was increased, while CDK8 was decreased in hypoxia-treated H9c2 cells." 33737500 3740 Rat rno-miR-9 miRNA hypoxia hypoxic/ischemic brain damage (HIBD) brain tissues 8% O2 + 92% N2 and sugar-free medium for 60 minutes treatment downregulated 25206848 3741 Rat rno-miR-9 miRNA oxygen glucose deprivation (OGD) ischemic brain injury Hippocampal neuronal oxygen-glucose deprivation (OGD) treatment upregulated 27074745 3742 Rat rno-miR-9 miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) ischemic stroke (IS) PC12 cells oxygen-glucose deprivation and reoxygenation (OGD/R) treatment SNHG7 was downregulated and miR-9 was upregulated by OGD/R treatment in PC12 cells 33262598 3743 Rat rno-miR-9 miRNA hypoxia neonatal hypoxic-ischemic brain damage PC12 cells; hippocampus hypoxia treatment upregulated 32470970 3744 Rat rno-miR-9 miRNA 1-methyl-4-phenylpyridinium (MPP+) parkinson's disease (PD) PC12 cells N-methyl-4-phenylpyridinium (MPP +) treatment "MPP+ toxicity significantly caused upregulated in miR-34a, miR-141, and miR-9." 29631008 3745 Rat rno-miR-9 miRNA hypoxia phenotypic switch of PASMCs rats pulmonary artery smooth muscle cells (PASMCs) hypoxia treatment upregulated 24615545 3746 Rat rno-miR-9 miRNA retinoic acid (RA) spina bifida spinal cord of rat Retinoic acid treatment downregulated 17962954 3747 Rat rno-miR-9 miRNA matrine spinal cord injury (SCI) PC-12 cells Matrine treatment LPS reduced miR-9 expression about 60%. 32297823 3748 Rat rno-miR-9* miRNA trimethyltin (TMT) neurotoxicity rats serum were given a single administration of TMT treatment upregulated 24777749 3749 Rat rno-miR-9* miRNA high fat diet (HFD) obesity rats high fat diet (HFD) feed dysregulated 24517225 3750 Rat rno-miR-9* miRNA retinoic acid (RA) spina bifida spinal cord of rat Retinoic acid treatment downregulated 17962954 3751 Rat rno-miR-9119 miRNA human chorionic gonadotrophin (hCG) polycystic ovarian syndrome (PCOS) ovarian granulosa cells (GCs) human chorionic gonadotrophin (hCG) treatment upregulated 31894528 3752 Rat rno-miR-92 miRNA butyrylated high-amylose maize starch (HAMSB) colorectal cancer (CRC) high-protein meat diet (HPM) fed rat colonic tissue butyrylated high-amylose maize starch (HAMSB) feed downregulated 31052187 3753 Rat rno-miR-92 miRNA high-amylose potato starch (HAPS) colorectal cancer (CRC) high-protein meat diet (HPM) fed rat colonic tissue high-amylose potato starch (HAPS) feed downregulated 31052187 3754 Rat rno-miR-92a miRNA lipopolysaccharide (LPS) acute lung injury (ALI) lung tissues lipopolysaccharide (LPS) treatment upregulated 33015189 3755 Rat rno-miR-92a miRNA hyperbaric oxygen (HBO) acute myocardial infarction (AMI) Rat cardiac myocytes Hyperbaric oxygen (HBO) treatment HBO-induced exosomes post-MI significantly reduced miR-92a expression compared with AMI alone at 14 days. 32939962 3756 Rat rno-miR-92a miRNA bone marrow mesenchymal stem cells (BMSCs) apoptosis infarcted rats myocardium bone marrow mesenchymal stem cells (BMSCs) treatment downregulated 28662151 3757 Rat rno-miR-92a miRNA H2O2 atherosclerosis (AS) Vascular smooth muscle cells (VSMCs) were primarily cultured from rat thoracic aortas hydrogen peroxide (H2O2) treatment downregulated 29115493 3758 Rat rno-miR-92a miRNA adenine chronic kidney disease (CKD) rats aortas; serum adenine upregulated 28696247 3759 Rat rno-miR-92a miRNA tetrodotoxin and AP5 effect of tetrodotoxin and AP5 rats hippocampal neurons tetrodotoxin and AP5 treatment downregulated 25017011 3760 Rat rno-miR-92a miRNA ethylene glycol monomethyl ether (EGME) hyperglycemia ?testicle of rat Ethylene glycol monomethyl ether (EGME) treatment "miR-449a and miR-92a decreased obviously and, miR-320, miR-134 and miR-188 increased" 22008535 3761 Rat rno-miR-92a miRNA losartan ischemia/reperfusion (I/R) injury heart tissues losartan treatment upregulated 26168042 3762 Rat rno-miR-92a miRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia treatment "Hypoxia stimulation significantly inhibited H9c2 cell viability and proliferation, induced cell apoptosis and upregulated miR-92a expression." 31949700 3763 Rat rno-miR-92a-1-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3764 Rat rno-miR-92a-2-5p miRNA ethylenethiourea (ETU) anorectal malformations (ARM) Hindgut tissue was isolated from the gestational day 14 fetuses ethylenethiourea (ETU) treatment upregulated 30106085 3765 Rat rno-miR-92a-2-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) inflammation primary brain microvascular endothelial cells (BMECs) oxygen-glucose deprivation and reoxygenation (OGD/R) treatment "?In particular, the expression levels of rno-miR-666-3p, rno-miR-92a-2-5p, and rno-miR-219a-2-3p decreased in OGD/R-exposed cells compared with those in the control" 33745435 3766 Rat rno-miR-92a-3p miRNA cold cold stress rats serum cold conditions (4¡æ for 12h) downregulated 28477904 3767 Rat rno-miR-92a-3p miRNA smoking smoke inhalation injury (SII) bronchoalveolar lavage fluid (BALF) Smoke inhalation treatment upregulated 30139538 3768 Rat rno-miR-92b miRNA adriamycin (ADR) nephrotic syndrome (NS) kidney tissues adriamycin (ADR) treatment upregulated 30551379 3769 Rat rno-miR-92b miRNA zhen-wu-tang (ZWT) nephrotic syndrome (NS) kidney tissues Zhen-wu-tang (ZWT) treatment downregulated 30551379 3770 Rat rno-miR-92b miRNA zhen-wu-tang (ZWT) nephrotic syndrome (NS) kidney tissues zhen-wu-tang (ZWT) treatment ZWT can decrease the expression of miR-92b and reverse the effect of miR-92b on AQP2 in vitro. 30551379 3771 Rat rno-miR-92b miRNA (+)-cholesten-3-one (CN) osteoblastic differentiation mesenchymal stem cells (MSCs) (+)-cholesten-3-one (CN) treatment downregulated 30373531 3772 Rat rno-miR-92b miRNA insulin-like growth factor 1 (IGF-1) post-stroke brain tissues Post-stroke ICV administration of IGF-1 to middle-aged female rats treatment downregulated 24618563 3773 Rat rno-miR-92b miRNA insulin-like growth factor 1 (IGF-1) spinal cord injury (SCI) Neural stem cells were obtained from E15 fetal rat cerebral cortex cultured supernatant exosomes insulin growth factor-1 (IFG-1) treatment upregulated 31848325 3774 Rat rno-miR-92b-3p miRNA resveratrol osteoporosis rat bone marrow mesenchymal stem cells (BMSCs) resveratrol (Res) treatment upregulated 32674689 3775 Rat rno-miR-92b-3p miRNA hypoxia pulmonary arterial hypertension (PAH) pulmonary artery smooth muscle cells (PASMCs) hypoxia induce downregulated 30149918 3776 Rat rno-miR-92b-3p miRNA smoking smoke inhalation injury (SII) bronchoalveolar lavage fluid (BALF) Smoke inhalation treatment upregulated 30139538 3777 Rat rno-miR-92b-3p miRNA insulin-like growth factor 1 (IGF-1) spinal cord injury (SCI) Neural stem cells were obtained from E15 fetal rat cerebral cortex cultured supernatant exosomes insulin growth factor-1 (IFG-1) treatment upregulated 31848325 3778 Rat rno-miR-92b-3p miRNA herb-partitioned moxibustion ulcerative colitis (UC) UC rats colon tissues herb-partitioned moxibustion upregulated 28246536 3779 Rat rno-miR-93 miRNA 17-AAG (tanespimycin) apoptosis tunicamycin-treated primary neonatal rat cardiomyocytes ?17-AAG (tanespimycin) treatment upregulated 30556167 3780 Rat rno-miR-93 miRNA tunicamycin (TM) apoptosis primary neonatal rat cardiomyocytes tunicamycin treatment downregulated 30556167 3781 Rat rno-miR-93 miRNA estradiol-17¦Â (E2) breast cancer mammary tissues estradiol-17¦Â (E2) treatment upregulated 23492819 3782 Rat rno-miR-93 miRNA vitamin C breast cancer mammary tissues vitamin C treatment downregulated 23492819 3783 Rat rno-miR-93 miRNA TGF-¦Â1 cardiac fibrosis primary rat cardiac fibroblasts TGF-¦Â1 treatment upregulated 29551367 3784 Rat rno-miR-93 miRNA angiotensin II (Ang II) cardiac hypertrophy cardiomyocytes angiotensin II (Ang II) treatment MIAT was upregulated and miR-93 was downregulated in AngII-treated cardiomyocytes. 29673400 3785 Rat rno-miR-93 miRNA platelet derived growth factor-BB (PDGF-BB) cell proliferation and migration rats vascular smooth muscle cell (VSMC) platelet-derived growth factor-BB (PDGF-BB) treatment upregulated 31754334 3786 Rat rno-miR-93 miRNA lipopolysaccharide (LPS) endotoxin-induced uveitis (EIU) macrophages lipopolysaccharide (LPS) treatment downregulated 24642374 3787 Rat rno-miR-93 miRNA furan hepatotoxicity liver Furan treatment upregulated 27371368 3788 Rat rno-miR-93 miRNA nerve growth factor (Ngf) neurodegenerative diseases PC12 cells 100 ng/ml Ngf treatment different regulation 24492999 3789 Rat rno-miR-93 miRNA dopamine agonist (DA) prolactinoma MMQ cells; GH3 cells dopamine agonist (DA) treatment miRNA-93 expression was elevated in DA-resistant prolactinomas. 30389900 3790 Rat rno-miR-93-3p miRNA lipopolysaccharide (LPS) inflammation H9c2 cells lipopolysaccharide (LPS) treatment downregulated 30195636 3791 Rat rno-miR-93-5p miRNA insert a cannula connected with a saline container into the anterior chamber acute ocular hypertension (AOH) adult albino rats retinal ganglion cells (RGCs) and microglial cells insert a cannula connected with a saline container into the anterior chamber downregulated 27535721 3792 Rat rno-miR-93-5p miRNA liraglutide endothelial dysfunction aortic endothelial in diabetic rats liraglutide treatment downregulated 30863684 3793 Rat rno-miR-93-5p miRNA N-methyl-D-aspartate (NMDA) glaucoma rat retinal ganglion cells N-me- thyl-D-aspartate (NMDA) treatment The level of miR-93-5p in the retina of rats with injection of NMDA was gradually declined over time. 29421576 3794 Rat rno-miR-93-5p miRNA IL-1¦Â osteoarthritis (OA) rat chondrocytes IL-1¦Â treatment upregulated 31253047 3795 Rat rno-miR-93-5p miRNA lipopolysaccharide (LPS) sepsis-induced myocardial injury H9c2 cells lipopolysaccharide (LPS) treatment "H19 and SORBS2 were downregulated in H9C2 cells following LPS treatment, while miR-93-5p was upregulated." 32996061 3796 Rat rno-miR-93-5p miRNA lipopolysaccharide (LPS) sepsis-induced myocardial injury H9C2 cells lipopolysaccharide (LPS) treatment H19 attenuated the development of sepsis-induced myocardial injury in vitro via modulation of the miR-93-5p/SORBS2 axis. 32996061 3797 Rat rno-miR-93-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3798 Rat rno-miR-939 miRNA hypoxia ischemic heart disease (IHD) H9c2 cardiac muscle cells hypoxia induce downregulated 31321998 3799 Rat rno-miR-93a-5p miRNA high fat diet (HFD) obesity white adipose tissues high fat diet (HFD) feed upregulated 32366215 3800 Rat rno-miR-942-5p miRNA doxorubicin (DOX) cardiomyocyte apoptosis Primary cardiomyocytes ?doxorubicin (DOX) treatment "SOX2-OT and DP5 were highly expressed, while miR-942-5p was downregulated in DOX-treated primary cardiomyocytes and rat model" 33603338 3801 Rat rno-miR-9-5p miRNA streptozocin (STZ) diabetes mellitus (DM) INS-1 cells streptozotocin (STZ) treatment downregulated 33826088 3802 Rat rno-miR-9-5p miRNA sevoflurane (SEV) hepatic ischemia/reperfusion injury (HIRI) liver ischemia/reperfusion (IR) rats liver tissues sevoflurane treatment upregulated 30906455 3803 Rat rno-miR-9-5p miRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia induce downregulated 30101604 3804 Rat rno-miR-9-5p miRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia treatment forced expression of miR-9-5p in H9c2 cells is concurrent with diminished expression of Fstl1 and vice versa. 30101604 3805 Rat rno-miR-9-5p miRNA IL-6 and TNF-¦Á rheumatoid arthritis (RA) Schwann cells TNF-¦Á treatment "In IL-6- and TNF-¦Á-stimulated Schwann cells, apoptosis was induced, while the cell viability and level of miR-9-5p were inhibited." 30456455 3806 Rat rno-miR-9-5p miRNA IL-6 and TNF-¦Á rheumatoid arthritis (RA) Schwann cells 0.1 ng/mL IL-6 and 20 ng/mL TNF-¦Á treatment downregulated 30456455 3807 Rat rno-miR-9-5p miRNA lithium (Li) spinal cord injury (SCI) spinal cord lithium treatment "Furthermore, lithium treatment alleviated the inflammatory response by inactivating the nuclear factor-kappa B (NF-¦ÊB) pathway and inhibited the expression of lncRNA brain-derived neurotrophic factor antisense (BDNF-AS) in SCI rats." 33464390 3808 Rat rno-miR-9-5p miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) traumatic brain injury (TBI) brain microvascular endothelial cells (BMECs); astrocytes oxygen-glucose deprivation and reoxygenation (OGD/R) treatment "upregulated of miRNA-9-5p alleviates BBB damage and neuroinflammatory responses by activating the Hedgehog pathway and inhibiting NF-¦ÊB/MMP-9 pathway, which promotes the recovery of neurological function after TBI" 33236776 3809 Rat rno-miR-96 miRNA sevoflurane (SEV) cognitive impairment hippocampus sevoflurane treatment upregulated 30217735 3810 Rat rno-miR-96 miRNA sevoflurane (SEV) cognitive impairment neonatal rats hippocampal neuron sevoflurane treatment upregulated 30217735 3811 Rat rno-miR-96 miRNA high fat diet (HFD) diabetic peripheral neuropathy (DPN) sciatic nerve tissues high fat diet (HFD) feed downregulated 29689688 3812 Rat rno-miR-96 miRNA streptozocin (STZ) diabetic peripheral neuropathy (DPN) sciatic nerve tissues streptozotocin (STZ) treatment downregulated 29689688 3813 Rat rno-miR-96 miRNA swimming diabetic peripheral neuropathy (DPN) diabetic rats sciatic nerve tissues swimming exercise induce treatment upregulated 29689688 3814 Rat rno-miR-96 miRNA streptozocin (STZ) diabetic retinopathy (DR) ?retinas?tissues streptozotocin (STZ) treatment upregulated 22156553 3815 Rat rno-miR-96 miRNA lipopolysaccharide (LPS) disseminated intravascular coagulation (DIC) liver tissues lipopolysaccharide (LPS) treatment upregulated 24806323 3816 Rat rno-miR-96 miRNA adreno-cortico-tropic-hormone (ACTH) hormonal regulation adrenals?tissues adreno-cortico-tropic-hormone (ACTH) treatment upregulated 24205079 3817 Rat rno-miR-96 miRNA estradiol-17¦Â (E2) hormonal regulation adrenals?tissues estradiol-17¦Â (E2) treatment upregulated 24205079 3818 Rat rno-miR-96 miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment downregulated 27041227 3819 Rat rno-miR-96 miRNA oxygen-glucose deprivation and reoxygenation (OGD/R) hypoxic/ischemic brain damage (HIBD) PC12 cell oxygen-glucose deprivation and reoxygenation (OGD/R) treatment downregulated 28721600 3820 Rat rno-miR-96 miRNA carbon black nanoparticle (CBNP) lung fibrosis lung tissues and whole lung lavage fluid (WLL) carbon black nanoparticle (CBNP) treatment downregulated 31683435 3821 Rat rno-miR-96 miRNA retinal toxicant pan-CDK inhibitors retinal toxicity rats in renal a single intravitreal (IVT) injection treatment upregulated 24114799 3822 Rat rno-miR-96 miRNA colesevelam zucker diabetic fatty (ZDF) liver tissues colesevelam treatment upregulated 30160993 3823 Rat rno-miR-96-5p miRNA high fat diet (HFD) aging-related non-alcoholic fatty liver disease (NAFLD) liver tissues high fat diet (HFD) feed downregulated 31899128 3824 Rat rno-miR-96-5p miRNA particulate matter (PM2.5) allergic rhinitis (AR) nasal mucosa particulate matter 2.5 (PM2.5) treatment downregulated 32192351 3825 Rat rno-miR-96-5p miRNA diethylnitrosamine (DEN) liver fibrosis liver tissues diethylnitrosamine (DEN) treatment upregulated 29236317 3826 Rat rno-miR-96-5p miRNA oxymatrine nonalcoholic fatty liver disease (NAFLD) liver tissues oxymatrine treatment upregulated 32679144 3827 Rat rno-miR-96-5p miRNA N-methyl-N-nitrosourea (MNU) retinal lesions serum N-methyl-N-nitrosourea (MNU) treatment "MNU at 50?mg/kg induced photoreceptor cell death, with elevation in serum miR-96-5p levels." 30336191 3828 Rat rno-miR-96-5p miRNA N-methyl-N-nitrosourea (MNU) retinal toxicity serum N-methyl-N-nitrosourea (MNU) treatment upregulated 30336191 3829 Rat rno-miR-97 miRNA quercetin oxidative stress PC-12 cells Quercetin treatment downregulated 33343808 3830 Rat rno-miR-98 miRNA H2O2 acute myocardial infarction (AMI) neonatal rat ventricular myocytes (NRVCs) H2O2 treatment downregulated 28784995 3831 Rat rno-miR-98 miRNA doxorubicin (DOX) cardiotoxicity neonatal rat ventricular myocytes doxorubicin (DOX) treatment we observed a significant increase in miR-98 expression in neonatal rat ventricular myocytes after DOX treatment 33617954 3832 Rat rno-miR-98 miRNA hypoxia hypoxic pulmonary hypertension (HPH) lung tissue and pulmonary artery (PA) smooth muscle cells (PASMCs) hypoxia induce downregulated 31322216 3833 Rat rno-miR-98 miRNA oxygen glucose deprivation (OGD) ischemic brain injury Hippocampal neuronal oxygen-glucose deprivation (OGD) treatment downregulated 27074745 3834 Rat rno-miR-98 miRNA "hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)" neurotoxicity brain tissues of rats RDX at a dose(47 mg/kg) for 48 h treatment upregulated 25559034 3835 Rat rno-miR-98 miRNA "quinacrine, erythromycin and tetracycline" non-surgical sterilization Wistar albino 12-14 week old female rats "quinacrine, erythromycin , tetracycline treatment" upregulated 25195052 3836 Rat rno-miR-98 miRNA steroids osteonecrosis of femoral head (ONFH) bone marrow mesenchymal stem cells (BMSCs) steroid treatment downregulated 27910957 3837 Rat rno-miR-98 miRNA sevoflurane (SEV) cognitive impairment BRL rat hepatocyte cell line 1 or 2 minimal alveolar concentrations sevoflurane for 4 or 8 h treatment upregulated 28260068 3838 Rat rno-miR-98 miRNA arsenic trioxide (ATO) lung fibrosis PF rat arsenic trioxide (As2O3) treatment upregulated 25123535 3839 Rat rno-miR-98 miRNA streptozocin (STZ) type 2 diabetes mellitus (T2DM) aortas streptozotocin (STZ) treatment downregulated 26840039 3840 Rat rno-miR-98-3p miRNA ¦Á-Lipoic acid (LA) longevity and neuroprotection cerebral cortex ¦Á-Lipoic acid (LA) treatment upregulated 26694192 3841 Rat rno-miR-98-5p miRNA cold cold stress rats serum cold conditions (4¡æ for 12h) downregulated 28477904 3842 Rat rno-miR-98-5p miRNA "2,4,6-trinitrobenzene sulfonic acid (TNBS)" ulcerative colitis (UC) colon tissues "2, 4, 6-Trinitrobenzenesulfonic acid solution (TNBS) treatment" upregulated 33394187 3843 Rat rno-miR-98-5p miRNA herb-partitioned moxibustion ulcerative colitis (UC) UC rats colon tissues herb-partitioned moxibustion upregulated 28246536 3844 Rat rno-miR-9995-3p miRNA bleomycin (BLM) lung fibrosis lung tissues bleomycin (BLM) treatment upregulated 33193637 3845 Rat rno-miR-99a miRNA isoproterenol cardiac hypertrophy H9c2 cells isoproterenol treatment miR-99a was upregulated during ISO- induced pathological hypertrophy. 29481791 3846 Rat rno-miR-99a miRNA nitrofen hypoplastic lung lung tissues nitrofen treatment upregulated 27041227 3847 Rat rno-miR-99a miRNA hypoxia myocardial infarction (MI) H9C2 cells hypoxia induce downregulated 29745968 3848 Rat rno-miR-99a miRNA hypoxia myocardial infarction (MI) H9c2 cells hypoxia treatment Hypoxia induced an increase of THRIL but a reduction of miR-99a and Brg1. 29745968 3849 Rat rno-miR-99a miRNA isoflurane oxidative stress H9c2 cells Isoflurane treatment upregulated 29627934 3850 Rat rno-miR-99a miRNA lithium chloride and pilocarpine status epilepticus (SE) rat hippocampus tissues lithium-pilocarpine treatment upregulated 21094214 3851 Rat rno-miR-99a-5p miRNA ethylenethiourea (ETU) anorectal malformations (ARM) Hindgut tissue was isolated from the gestational day 14 and day 16 fetuses ethylenethiourea (ETU) treatment upregulated 30106085 3852 Rat rno-miR-99a-5p miRNA steroids osteonecrosis of femoral head (ONFH) serum steroid treatment upregulated 29887962 3853 Rat rno-miR-99a-5p miRNA lipopolysaccharide (LPS) septic shock heart tissue lipopolysaccharide (LPS) treatment dysregulated 31332662 3854 Rat rno-miR-99b miRNA isoproterenol cardiac hypertrophy H9c2 cells isoproterenol treatment miR-99b was upregulated during ISO- induced pathological hypertrophy. 29481791 3855 Rat rno-miR-99b miRNA deoxycorticosterone acetate (DOCA) -salt (sodium chloride) hypertension heart tissues deoxycorticosterone acetate (DOCA) -salt (sodium chloride) treatment downregulated 30290168 3856 Rat rno-miR-99b miRNA metformin (Met) hypertension deoxycorticosterone acetate (DOCA) -salt (sodium chloride)-induced hypertension rats heart tissues metformin (MF) treatment upregulated 30290168 3857 Rat rno-miR-99b miRNA deoxycorticosterone acetate (DOCA) -salt (sodium chloride) hypertension-induced cardiac dysfunction heart tissues deoxycorticosterone acetate (DOCA) -salt (sodium chloride) treatment downregulated 30290168 3858 Rat rno-miR-99b miRNA metformin (Met) hypertension-induced cardiac dysfunction heart tissues Metformin treatment upregulated 30290168 3859 Rat rno-miR-99b miRNA phosphodiesterase 5 (PDE5) inhibitor nonalcoholic fatty liver disease (NAFLD) plasma exosomes phosphodiesterase 5 (PDE5) inhibitor treatment upregulated 33396535 3860 Rat rno-miR-99b-5p miRNA glucocorticoid (GC) respiratory distress syndrome lung Glucocorticoids treatment downregulated 26997989 3861 Rat rno-miR-9a-5p miRNA hypoxia cerebral ischemia injury (CII) rats ischemic region middle cerebral artery occlusion (MCAO) treatment downregulated in the ischemic region 29316542 3862 Rat rno-miR-9a-5p miRNA H2O2 myocardial infarction (MI) cultured cardiomyocytes H2O2 treatment downregulated 31787746