116HG Prader-Willi syndrome Regulation "Long ncRNA 116HG has been shown to play a role in the development of Prader–Willi syndrome (PWS) (Powell et al., 2013)." N/A N/A N/A N/A Human N/A N/A 24624135 1B FGF-antisense transcripts endometriosis Expression "Mihalich et al, reported patients with endometriosis show low expression of 1B FGF-antisense transcripts, which correlates with endometrial cell proliferation" N/A N/A N/A N/A Human N/A N/A 23781896 4930503E24Rik ischaemia-reperfusion injury Expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. chr10 124469074 124524488 + Mouse 4930503E24Rik NR_028310 24312245 51A Alzheimer's disease Regulation "51A expression drives a splicing shift of SORL1 from the synthesis of the canonical long protein variant 1 to an alternatively spliced protein form. This process, resulting in a decreased synthesis of SORL1 variant 1, is associated with an impaired processing of APP, leading to increase of A formation. " N/A N/A N/A N/A Human N/A N/A 22996644 5730458M16Rik heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 22 downregulated in HF hearts as compared with control hearts. N/A N/A N/A N/A Mouse N/A AK020791.1 24205036 RN7SK AIDS Expression Stable expression of cdNIPP1 increased CDK9 phosphorylation on Thr(186) and the association of CDK9 with 7SK RNA. The stable expression of cdNIPP1 disrupted the interaction of Tat and PP1 and inhibited HIV-1 transcription. Expression of cdNIPP1 as a part of the HIV-1 genome inhibited HIV-1 replication. chr6 52995620 52995951 + Human 7SK NR_001445 21098020 RN7SK AIDS Interaction HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. chr6 52995620 52995951 + Human 7SK NR_001445 20471949 RN7SK AIDS Interaction "Tat efficiently replaces HEXIM1 on the 7SK snRNA in vivo and therefore, it promotes the disassembly of the 7SK/HEXIM/P-TEFb negative transcriptional regulatory snRNP to augment the nuclear level of active P-TEFb. The human 7SK snRNA carries a TAR RNA-like Tat-binding element that is essential for the normal transcriptional regulatory function of 7SK questions the viability of HIV therapeutic approaches based on small drugs blocking the Tat-binding site of HIV TAR." chr6 52995620 52995951 + Human 7SK NR_001445 20976203 RN7SK AIDS Interaction "The 7SK-HMGA1 interaction not only adds an essential facet to the comprehension of transcriptional plasticity at the coupling of initiation and elongation, but also might provide a molecular link between HIV reprogramming of cellular gene expression-associated oncogenesis." chr6 52995620 52995951 + Human 7SK NR_001445 21087998 RN7SK AIDS Interaction The HIV-1 Tat protein also releases P-TEFb from the 7SK/HEXIM complex during viral infection to promote viral transcription and replication. chr6 52995620 52995951 + Human 7SK NR_001445 22377309 RN7SK cancer Interaction "Together with the HEXIM proteins, 7SK RNA associates with and sequesters a fraction of cellular P-TEFb into a catalytically inactive complex. Active and inactive forms of P-TEFb are kept in a functional and dynamic equilibrium tightly linked to the transcriptional requirement of the cell. Importantly, cardiac hypertrophy and development of various types of human malignancies have been associated with increased P-TEFb activity, consequence of a disruption of this regulatory equilibrium." chr6 52995620 52995951 + Human 7SK NR_001445 22377309 RN7SK cardiac hypertrophy Interaction "Together with the HEXIM proteins, 7SK RNA associates with and sequesters a fraction of cellular P-TEFb into a catalytically inactive complex. Active and inactive forms of P-TEFb are kept in a functional and dynamic equilibrium tightly linked to the transcriptional requirement of the cell. Importantly, cardiac hypertrophy and development of various types of human malignancies have been associated with increased P-TEFb activity, consequence of a disruption of this regulatory equilibrium." chr6 52995620 52995951 + Human 7SK NR_001445 22377309 RN7SK gastric cancer Expression Transfection of an siRNA directed against LARP7 (anti-LARP7 siRNA) into non-neoplastic gastric epithelial cells decreased 7sk levels by 72% relative to a control siRNA (P<0.01). chr6 52995620 52995951 + Human 7SK NR_001445 22488152 RN7SL1 AIDS Interaction "7SL RNA, but not the 54-kd signal recognition particle protein, is an abundant component of both infectious HIV-1 and minimal virus-like particles." chr14 49586580 49586878 + Human 7L1a; 7SL; RN7SL; RNSRP1 NR_002715 16489186 RN7SL1 AIDS N/A 7SL RNA binding is a conserved feature of human anti-HIV-1 cytidine deaminases. chr14 49586580 49586878 + Human 7L1a; 7SL; RN7SL; RNSRP1 NR_002715 20926562 RN7SL1 dermatomyositis Interaction Autoantibodies against signal recognition particle (SRP) are detected in patients with polymyositis/dermatomyositis (PM/DM). The SRP consists of 7SL RNA and 6 protein components. chr14 49586580 49586878 + Human 7L1a; 7SL; RN7SL; RNSRP1 NR_002715 16142868 RN7SL1 Leishmaniasis Expression Down-regulation of 7SL RNA expression and impairment of vesicular protein transport pathways by Leishmania infection of macrophages. chr14 49586580 49586878 + Human 7L1a; 7SL; RN7SL; RNSRP1 NR_002715 15955815 RN7SL1 Leishmaniasis Expression High-resolution melt analysis PCR (HRM PCR) for diagnosis of Old World Leishmania was developed using the 7SL RNA gene. Cutaneous leishmaniasis samples were analyzed. Sensitivity and specificity of HRM PCR were significantly better (P < 0.001) than those of internal transcribed spacer 1 PCR and similar to those of kinetoplast DNA PCR. chr14 49586580 49586878 + Human 7L1a; 7SL; RN7SL; RNSRP1 NR_002715 20392923 RN7SL1 Leishmaniasis N/A Leishmania 7SLRNA is an informative target for clinical and epidemiologic investigations of human leishmaniasis. chr14 49586580 49586878 + Human 7L1a; 7SL; RN7SL; RNSRP1 NR_002715 20856851 RN7SL1 Leishmaniasis N/A "The 7SL RNA PCR has proven useful for direct diagnosis of Old World leishmaniasis, especially when combined with the RBD assay for species identification." chr14 49586580 49586878 + Human 7L1a; 7SL; RN7SL; RNSRP1 NR_002715 20561310 RN7SL1 polymyositis Interaction Autoantibodies against signal recognition particle (SRP) are detected in patients with polymyositis/dermatomyositis (PM/DM). The SRP consists of 7SL RNA and 6 protein components. chr14 49586580 49586878 + Human 7L1a; 7SL; RN7SL; RNSRP1 NR_002715 16142868 A130040M12Rik cancer Expression These results indicate that PSF is a major tumor-suppressor protein and VL30-1 RNA is a major tumor-promoter RNA in mice. N/A N/A N/A N/A Mouse N/A N/A 19805375 AC002511.1 enterovirus 71 infection Expression "A general consistency between the qPCR and microarray analysis results was confirmed in four lncRNAs (AP000688.29, AC002511.1, RP5-843L14.1, and RP4-620F22.3) in terms of regulation direction and significance. Specifically, a 3.31-fold down-regulation " chr19 35399511 35419385 + Human LINC01531 ENST00000600405 23220233 ACTA2-AS1 lung adenocarcinoma Expression Enhanced expression of long non-coding RNA ZXF1 promoted the invasion and metastasis in lung adenocarcinoma. chr10 88932684 88939974 + Human ZXF1; uc001kfo.1 NR_125373 24721325 ADAMTS9-AS2 glioma Regulation A new tumor suppressor LncRNA ADAMTS9-AS2 is regulated by DNMT1 and inhibits migration of glioma cells. chr3 64684870 65011468 + Human N/A NR_038264 24833086 AF086415 nasopharyngeal carcinoma Expression "Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294004) were confirmed by qPCR. " N/A N/A N/A N/A Human N/A AF086415.1 24379026 AFAP1-AS1 Barrett's Esophagus Expression "Hypomethylation of Noncoding DNA Regions and Overexpression of the Long Noncoding RNA, AFAP1-AS1, in Barrett's Esophagus and Esophageal Adenocarcinoma." chr4 7754090 7778928 + Human AFAP1-AS; AFAP1AS NR_026892 23333711 Airn alcoholic liver disease Expression "Up regulation in liver by DDC (Diethyl 1,4-dihydro-2,4,6,-trimethyl-3,5-pyridinedicarboxylate )." chr17 12741311 12859884 + Mouse 2810051F02Rik; 2810434M15Rik; AI256653; AI597500; AW049873; Air; B930018I07Rik; D17Ertd663e; IGF2RAS NR_027773 19362547 Airn chronic nonalcoholic liver disease Expression "Up regulation in liver by DDC (Diethyl 1,4-dihydro-2,4,6,-trimethyl-3,5-pyridinedicarboxylate )." chr17 12741311 12859884 + Mouse 2810051F02Rik; 2810434M15Rik; AI256653; AI597500; AW049873; Air; B930018I07Rik; D17Ertd663e; IGF2RAS NR_027773 19362547 Airn hepatocellular carcinoma Expression "Up regulation in liver by DDC (Diethyl 1,4-dihydro-2,4,6,-trimethyl-3,5-pyridinedicarboxylate ). Furthermore, over expression of H19 and AIR was demonstrated in tumors formed in mice withdrawn for 9 months." chr17 12741311 12859884 + Mouse 2810051F02Rik; 2810434M15Rik; AI256653; AI597500; AW049873; Air; B930018I07Rik; D17Ertd663e; IGF2RAS NR_027773 19362547 AK023948 papillary thyroid carcinoma Expression Gene expression analysis indicated that AK023948 is significantly down-regulated in most PTC tumors. The putative noncoding RNA gene AK023948 is a candidate susceptibility gene for PTC. N/A N/A N/A N/A Human N/A AK023948 19147577 AK028007 ischaemia-reperfusion injury Expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. N/A N/A N/A N/A Mouse N/A AK028007.1 24312245 AK038798 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 16 downregulated in HF hearts as compared with control hearts. N/A N/A N/A N/A Mouse N/A AK038798.1 24205036 AK042766 restless legs syndrome Expression "A recent study suggested that the predisposition to RLS results from reduced expression of Meis1 mediated by intronic cis-regulatory elements. Intriguingly, in the developing mouse brain, Meis1 is co-expressed in the developing cerebellar granule cell layer along with a genomically-associated lncRNA AK042766" N/A N/A N/A N/A Mouse N/A AK042766 19696892 AK044955 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 7 downregulated in HF hearts as compared with control hearts. N/A N/A N/A N/A Mouse N/A AK044955.1 24205036 AK049728 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 5 downregulated in HF hearts as compared with control hearts. N/A N/A N/A N/A Mouse N/A AK049728.1 24205036 AK056098 nasopharyngeal carcinoma Expression "Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294008) were confirmed by qPCR." N/A N/A N/A N/A Human N/A AK056098.1 24379026 AK095147 nasopharyngeal carcinoma Expression "Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294005) were confirmed by qPCR." N/A N/A N/A N/A Human N/A AK095147.1 24379026 AK137898 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 4 downregulated in HF hearts as compared with control hearts. N/A N/A N/A N/A Mouse N/A AK137898.1 24205036 AK139328 ischaemia-reperfusion injury Regulation Silencing of Long Noncoding RNA AK139328 Attenuates Ischemia/Reperfusion Injury in Mouse Livers. N/A N/A N/A N/A Mouse N/A AK139328.1 24312245 AK139328 ischaemia-reperfusion injury Expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. N/A N/A N/A N/A Mouse N/A AK139328.1 24312245 AK143294 ischaemia-reperfusion injury Expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. N/A N/A N/A N/A Mouse N/A AK143294.1 24312245 AK143693 ischaemia-reperfusion injury Expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. N/A N/A N/A N/A Mouse N/A AK143693.1 24312245 AK144081 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 21 downregulated in HF hearts as compared with control hearts. N/A N/A N/A N/A Mouse N/A AK144081.1 24205036 AK153778 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 26 downregulated in HF hearts as compared with control hearts. N/A N/A N/A N/A Mouse N/A AK153778.1 24205036 AK294004 nasopharyngeal carcinoma Expression "Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294009) were confirmed by qPCR." N/A N/A N/A N/A Human N/A AK294004.1 24379026 Alg2 ischaemia-reperfusion injury Expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. N/A N/A N/A N/A Mouse N/A AK209601.1 24312245 Alu lncRNAs macular degeneration Expression "Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms" N/A N/A N/A N/A Human N/A N/A 23791884 CDKN2B-AS1 atherosclerosis Mutation Chr9p21 encodes the long non-coding RNA (ncRNA) antisense non-coding RNA in the INK4 locus (ANRIL). ANRIL expression is associated with the Chr9p21 genotype and correlated with atherosclerosis severity chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23861667 CDKN2B-AS1 atherosclerosis Regulation "The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23813974 CDKN2B-AS1 cancer Regulation "The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23813974 CDKN2B-AS1 periodontitis Regulation "The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23813974 CDKN2B-AS1 prostate cancer Expression "Recent studies have linked their mis-expression to diverse cancers (ANRIL: prostate cancer, XIST: female cancers, HOTAIR: breast cancer, KCNQ1OT1: colorectal cancer)." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23660942 anti-NOS2A glioblastoma Expression anti-NOS2A is a lncRNA that is expressed in meningiomas and glioblastomas from a genomic locus that evolved by duplication of the NOS2A gene followed by internal DNA inversion. N/A N/A N/A N/A Human N/A N/A 18820242 anti-NOS2A meningioma Expression anti-NOS2A is a lncRNA that is expressed in meningiomas and glioblastomas from a genomic locus that evolved by duplication of the NOS2A gene followed by internal DNA inversion. N/A N/A N/A N/A Human N/A N/A 18820242 AP000688.29 enterovirus 71 infection Expression "A general consistency between the qPCR and microarray analysis results was confirmed in four lncRNAs (AP000688.29, AC002511.1, RP5-843L14.1, and RP4-620F22.3) in terms of regulation direction and significance. Specifically, a 3.31-fold down-regulation (2.25-fold in microarray analysis) was observed in AP000688.29, 3.33-fold up-regulation (2.77-fold in microarray analysis) in AC002511.1, 2.29-fold up-regulation (2.40-fold in microarray analysis) in RP5-843L14.1, and 2.99-fold up-regulation (2.22-fold in microarray analysis) in RP4-620F22.3" chr21 36104881 36109690 + Human AP000688.2 ENST00000422473 23220233 FMR1-AS1 fragile X syndrome Expression ASFMR1 is silenced in FXS patients and up regulated in pre-mutation carriers suggesting that a common process is responsible for regulating the expression these transcripts. chrX 147909431 147911817 - Human ASFMR1; FMR1-AS; FMR1AS; FMR4 NR_024499 17921506 ATP6V1G2-DDX39B dilated cardiomyopathy Mutation "The haplotype block, NFKBIL1-ATP6V1G2-BAT1-MICB-MICA, within the class III-class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus-associated dilated cardiomyopathy." chr6 31530219 31546848 - Human N/A NR_037853 16101831 ATP6V1G2-DDX39B hepatitis C virus-associated dilated cardiomyopathy Mutation "The haplotype block, NFKBIL1-ATP6V1G2-BAT1-MICB-MICA, within the class III-class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus-associated dilated cardiomyopathy." chr6 31530219 31546848 - Human N/A NR_037853 16101831 ATXN8OS spinocerebellar ataxia Expression RNA gain-of-function plays a significant role in SCA8: 1) CUG(exp) transcripts accumulate as ribonuclear inclusions that co-localize with MBNL1 in selected neurons in the brain. chr13 70107213 70139753 + Human KLHL1AS; NCRNA00003; SCA8 NR_002717 19680539 ATXN8OS spinocerebellar ataxia Expression RNA gain-of-function plays a significant role in SCA8: 1) CUG(exp) transcripts accumulate as ribonuclear inclusions that co-localize with MBNL1 in selected neurons in the brain. chr13 70107213 70139753 + Human KLHL1AS; NCRNA00003; SCA8 NR_002717 19680539 ATXN8OS spinocerebellar ataxia Expression Spinocerebellar ataxia type 8 (SCA8) involves bidirectional expression of CUG (ATXN8OS) and CAG (ATXN8) expansion transcripts. chr13 70107213 70139753 + Human KLHL1AS; NCRNA00003; SCA8 NR_002717 19229559 ATXN8OS spinocerebellar ataxia Locus "Patients show a trinucleotide (CUG) expansion in a noncoding RNA termed ataxin 8 opposite strand (ATXN8OS), an antisense transcript to the KLHL1 gene." chr13 70107213 70139753 + Human KLHL1AS; NCRNA00003; SCA8 NR_002717 16804541 ATXN8OS spinocerebellar ataxia Mutation The ATXN8OS (CTA)n(CTG)n composite repeat expansion is transmitted in an autosomal dominant manner with reduced penetrance. chr13 70107213 70139753 + Human KLHL1AS; NCRNA00003; SCA8 NR_002717 20301445 ATXN8OS spinocerebellar ataxia Mutation The low prevalence of SCA8 seems to be correlated with the low frequency of large (CTA/CTG)n copy number alleles in Chinese population. chr13 70107213 70139753 + Human KLHL1AS; NCRNA00003; SCA8 NR_002717 18841561 ATXN8OS spinocerebellar ataxia Mutation Genetic variation in lncRNA genes causes disease and influences susceptibility chr13 70107213 70139753 + Human KLHL1AS; NCRNA00003; SCA8 NR_002717 23791884 ATXN8OS spinocerebellar ataxia Interaction ATXN8OS transcript contributes to SCA8 pathogenesis by altering the activity of MBNL/CELF alternative splicing proteins. chr13 70107213 70139753 + Human KLHL1AS; NCRNA00003; SCA8 NR_002717 20380817 ATXN8OS spinocerebellar ataxia Mutation Expansion repeats in the ATXN8OS lncRNA gene are partly responsible for the pathology of spinocerebellar ataxia type 8 through a toxic RNA gain-of-function mechanism that includes formation of ribonuclear inclusions in the cerebellum and deregulation of muscleblind-like splicing regulator 1-mediated alternative splicing chr13 70107213 70139753 + Human KLHL1AS; NCRNA00003; SCA8 NR_002717 22814587 B1 SINE RNA infection of mouse minute virus Expression Increased levels of B1 and B2 SINE transcripts in mouse fibroblast cells due to minute virus of mice infection. N/A N/A N/A N/A Mouse N/A N/A 15351211 B2 SINE RNA infection of chicken embryo lethal orphan adenovirus Interaction CELO protein Gam1 was able to mediate transcriptional activation of these B2 SINE-containing RNAs. Upregulation of B2-SINE-containing RNAs could be a novel contribution of Gam1 to CELO host cell infection. N/A N/A N/A N/A Mouse N/A N/A 12729754 B2 SINE RNA infection of mouse minute virus Expression Increased levels of B1 and B2 SINE transcripts in mouse fibroblast cells due to minute virus of mice infection. N/A N/A N/A N/A Mouse N/A N/A 15351211 B2 SINE RNA pain Expression "Comt1 is differentially expressed among the strains, and this differential expression is cis-regulated. A B2 short interspersed nuclear element (SINE) was inserted in the 3'-untranslated region (3'-UTR) of Comt1 in 14 strains generating a common haplotype that correlates with gene expression. A haplotype, defined by a 3'-UTR B2 SINE element, regulates Comt1 expression and some mouse behaviors." N/A N/A N/A N/A Mouse N/A N/A 20659173 BACE1-AS Alzheimer's disease Expression "Elevated levels of Ab, BACE1 proteins, as well as BACE1-AS have been detected in subjects with Alzheimer's disease (AD), suggesting that altered BACE1 expression plays a role in the pathogenesis of the disease." chr11 117291346 117292170 + Human BACE1-AS1; BACE1AS; NCRNA00177 NR_037803 18587408 BACE1-AS Alzheimer's disease Expression The BACE1-antisense transcript (BACE1-AS) is markedly upregulated in brain samples from AD patients and promotes the stability of the (sense) BACE1 transcript. chr11 117291346 117292170 + Human BACE1-AS1; BACE1AS; NCRNA00177 NR_037803 21785702 BACE1-AS Alzheimer's disease Interaction BACE1-AS is directly implicated in the increased abundance of A?1-42 in Alzheimer's disease. chr11 117291346 117292170 + Human BACE1-AS1; BACE1AS; NCRNA00177 NR_037803 18587408 BACE1-AS Alzheimer's disease Interaction BACE1-AS is directly implicated in the increased abundance of A?1-42 in Alzheimer's disease. chr11 117291346 117292170 + Human BACE1-AS1; BACE1AS; NCRNA00177 NR_037803 18587408 BACE1-AS Alzheimer's disease Interaction The BACE1-antisense transcript (BACE1-AS) regulates BACE1 mRNA and subsequently BACE1 protein expression in vitro and in vivo. BACE1 mRNA expression is under the control of a regulatory noncoding RNA that may drive Alzheimer's disease-associated pathophysiology. chr11 117291346 117292170 + Human BACE1-AS1; BACE1AS; NCRNA00177 NR_037803 18587408 BACE1-AS Alzheimer's disease Expression "BACE1 is one of two peptidases that carry out the initial proteolytic cleavage of APP, allowing it to accumulate in the brain. BACE1AS levels were found to be higher in human subjects with AD, and also in BACE1 transgenic mouse models of AD " chr11 117291346 117292170 + Human BACE1-AS1; BACE1AS; NCRNA00177 NR_037803 22817756 BACE1-AS Alzheimer's disease Expression "BACE1-AS is elevated in brains of patients with AD, suggesting that the lncRNA is the driving force behind BACE1 dysregulation in AD" chr11 117291346 117292170 + Human BACE1-AS1; BACE1AS; NCRNA00177 NR_037803 23562612 BACE1-AS Alzheimer's disease Expression The expression of BACE1 antisense transcript (BACE1-AS) was linked to increased amyloid-β 1?2 in patients with Alzheimer’s disease and gave rise for a stabilizing function of the lncRNA. chr11 117291346 117292170 + Human BACE1-AS1; BACE1AS; NCRNA00177 NR_037803 24531795 BACE1-AS Alzheimer's disease Expression he accumulation of this protein has been implicated in many neurological disorders and elevated levels of both BACE1 and BACE1-AS have been detected in subjects with Alzheimer's disease chr11 117291346 117292170 + Human BACE1-AS1; BACE1AS; NCRNA00177 NR_037803 22928560 BACE1-AS Alzheimer's disease Regulation Genomic context links lncRNAs to disease genes/loci and related pathways chr11 117291346 117292170 + Human BACE1-AS1; BACE1AS; NCRNA00177 NR_037803 23791884 BACE1-AS Alzheimer's disease Regulation "In Alzheimer disease, the protein-coding gene BACE-1 (β-site amyloid precursor protein-cleaving enzyme) cleaves amyloid precursor protein (APP) to β-amyloid peptide (Aβ), the accumulation of which (amyloid plaques) is associated with disease. LncRNA BACE1-AS, located on the antisense strand to BACE1, binds complementarily to BACE1 mRNA, increases its stability, regulates BACE1 translation, and thereby the production of Aβ." chr11 117291346 117292170 + Human BACE1-AS1; BACE1AS; NCRNA00177 NR_037803 24667321 BACE1-AS Alzheimer's disease Regulation "It has been shown that misexpression of lncRNAs contributes to numerous diseases. For example, an lncRNA may influence the pathogenesis of Alzheimer's disease. The BACE1-AS can regulate BACE1 mRNA expression. BACE1 mRNA expression is under the control of a regulatory non-coding RNA that may drive Alzheimer's disease-associated pathophysiology" chr11 117291346 117292170 + Human BACE1-AS1; BACE1AS; NCRNA00177 NR_037803 22535282 BACE1-AS inclusion body myositis Regulation Genomic context links lncRNAs to disease genes/loci and related pathways chr11 117291346 117292170 + Human BACE1-AS1; BACE1AS; NCRNA00177 NR_037803 23791884 BANCR melanoma N/A "BRAF-regulated lncRNA 1 (BANCR) was identified as a recurrently overexpressed, previously unannotated 693-bp transcript on chromosome 9 with a potential functional role in melanoma cell migration. " chr9 69296681 69307056 - Human LINC00586 NR_047671 22581800 BANCR melanoma Regulation "This screen revealed a 693 bp novel lncRNA transcript, named BRAF-activated non-coding RNA (BANCR).Depletion of BANCR in melanoma cells resulted in profound migration defects, indicating a significant role of BANCR in regulation of melanoma cell motility. " chr9 69296681 69307056 - Human LINC00586 NR_047671 24115003 BANCR non-small cell lung cancer Expression Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesenchymal transition. chr9 69296681 69307056 - Human LINC00586 NR_047671 24655544 BC040587 osteosarcoma Mutation These CNAs (copy number alterations) in osteosarcoma often involve the noncoding RNAs LOC285194 and BC040587. N/A N/A N/A N/A Human N/A N/A 20048075 BCAR4 breast cancer Expression BCAR4 is expressed in 27% of primary breast tumors. Forced expression of BCAR4 in human ZR-75-1 and MCF7 breast cancer cells resulted in cell proliferation in the absence of estrogen and in the presence of various antiestrogens.BCAR4 may be a good target for treating antiestrogen-resistant breast cancer. chr16 11819830 11828832 - Human N/A NR_024050 21506106 BCAR4 breast cancer Expression "High BCAR4 mRNA levels were associated with poor MFS and overall survival, reflecting tumour aggressiveness." chr16 11819830 11828832 - Human N/A NR_024050 20859285 BCAR4 breast cancer N/A "Breast cancer anti-estrogen resistance 4 (BCAR4), caused OH-TAM resistance and anchorage-independent cell growth in ZR-75-1 cells." chr16 11819830 11828832 - Human N/A NR_024050 16778085 BCAR4 breast cancer Expression BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinib. chr16 11819830 11828832 - Human N/A NR_024050 22892392 BCYRN1 aging Expression "In normal aging, BC200 levels in cortical areas were reduced by >60% between the ages of 49 and 86. In contrast, BC200 RNA was significantly up-regulated in AD brains, in comparison with age-matched normal brains." chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 17553964 BCYRN1 Alzheimer's disease Expression "In normal aging, BC200 levels in cortical areas were reduced by >60% between the ages of 49 and 86. In contrast, BC200 RNA was significantly up-regulated in AD brains, in comparison with age-matched normal brains." chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 17553964 BCYRN1 Alzheimer's disease Expression "Increased levels of BC200 were found in brain regions that are preferentially affected in AD. Further, in advanced stages of AD, BC200 was mis-localized and clustered in the perikaryon. These observations suggest that deregulation of these synaptic lncRNAs is involved in the synaptic and neural network dysfunction that is found in both early and later stages of AD." chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 20380817 BCYRN1 Alzheimer's disease Expression "BC200 levels in Brodmann's area 9 (the area of brain affected in AD) were found to be higher in age-matched AD brains compared with normal brains, and the relative levels of BC200 RNA in affected areas increased with the severity of AD." chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 23562612 BCYRN1 breast cancer Expression "BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues." chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 9422992 BCYRN1 breast cancer Expression "In ductal carcinomas in situ, furthermore, significant BC200 (BCYRN1) expression was associated with high nuclear grade, suggesting that the presence of BC200 RNA in such tumors may be used as a prognostic indicator of tumor progression." chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 15240511 BCYRN1 cervical cancer Expression "BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues." chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 9422992 BCYRN1 lung cancer Expression "BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues." chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 9422992 BCYRN1 esophageal cancer Expression "BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues." chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 9422992 BCYRN1 ovarian cancer Expression "BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues." chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 9422992 BCYRN1 parotid cancer Expression "BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues." chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 9422992 BCYRN1 tongue cancer Expression "BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues." chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 9422992 BDNF-AS depression Regulation "The lncRNA BDNF-AS is related to many neurological disorders, including Huntington's disease (HD), schizophrenia, and depression." chr11 27506852 27698171 + Human ANTI-BDNF; BDNF1; BDNFOS; NCRNA00049; BDNF-AS NR_033314 23562612 BDNF-AS Huntington's disease Regulation "The lncRNA BDNF-AS is related to many neurological disorders, including Huntington's disease (HD), schizophrenia, and depression." chr11 27506852 27698171 + Human ANTI-BDNF; BDNF1; BDNFOS; NCRNA00049; BDNF-AS NR_033314 23562612 BDNF-AS Huntington's disease Regulation "Thus, BDNF-AS inhibits BDNF transcription by recruiting EZH2 to the BDNF promoter region and in that way plays an important role in the development of HD." chr11 27506852 27698171 + Human ANTI-BDNF; BDNF1; BDNFOS; NCRNA00049; BDNF-AS NR_033314 24624135 BDNF-AS psychiatric disease Regulation "Examples of recently discovered chromatin-bound long non-coding RNAs important for neuronal health and function include the brain-derived neurotrophic factor antisense transcript (Bdnf-AS) which regulates expression of the corresponding sense transcript, and LOC389023 which is associated with human-specific histone methylation signatures at the chromosome 2q14.1 neurodevelopmental risk locus by regulating expression of DPP10, an auxillary subunit for voltage-gated K(+) channels." chr11 27506852 27698171 + Human ANTI-BDNF; BDNF1; BDNFOS; NCRNA00049; BDNF-AS NR_033314 23831425 BDNF-AS schizophrenia Regulation "The lncRNA BDNF-AS is related to many neurological disorders, including Huntington's disease (HD), schizophrenia, and depression." chr11 27506852 27698171 + Human ANTI-BDNF; BDNF1; BDNFOS; NCRNA00049; BDNF-AS NR_033314 23562612 BDNF-AS1 obesity Locus "This locus maps near key hypothalamic regulators of energy balance, may be associated with obesity." N/A N/A N/A N/A Human N/A N/A 20935630 BDNF-AS1 obesity Mutation "Association identified by GWAS (rs4074134, A118887G)." N/A N/A N/A N/A Human N/A N/A 19079260 BLACAT1 bladder cancer Expression Theseguilty by association studies have found numerous bladder-cancer associated lncRNAs chr1 205434886 205456086 - Human LINC00912; linc-UBC1; onco-lncRNA-30 NR_103783 24006935 BOK-AS1 cancer Expression The expression of BOKAS was found in testis and certain cancer tissues but not in other normal adult tissues. Overexpression of BOKAS was able to inhibit Bok-induced apoptosis in HeLa cells. chr2 241544384 241559143 - Human BOK-AS; BOKAS; NAToB; NCRNA00151 NR_033346 24757675 BOK-AS1 testicular cancer Expression "A natural antisense transcript, BOKAS, regulates the pro-apoptotic activity of human Bok. The mRNA expression of BOKAS was only detected in testis and certain cancer tissues but not in other normal adult tissues examined." chr2 241544384 241559143 - Human BOK-AS; BOKAS; NAToB; NCRNA00151 NR_033346 19287972 BPESC1 blepharophimosis syndrome Mutation "BPESC1 is disrupted by a balanced chromosomal translocation, t(3;4)(q23;p15.2), in a patient with BPES." chr3 139104185 139125167 + Human NCRNA00187 NR_026783 10995571 BX118339 West syndrome Mutation "A de novo balanced t(2;6)(p15;p22.3) in a patient with West Syndrome disrupts a lnc-RNA, BX118339." N/A N/A N/A N/A Human N/A N/A 22245136 BX118339 West syndrome Mutation Genetic variation in lncRNA genes causes disease and influences susceptibility N/A N/A N/A N/A Human N/A N/A 23791884 C15orf2 Angelman syndrome Expression C15orf2 and a novel noncoding transcript from the Prader-Willi/Angelman syndrome region show monoallelic expression in fetal brain. N/A N/A N/A N/A Human N/A N/A 17337158 C15orf2 Prader-Willi syndrome Expression C15orf2 and a novel noncoding transcript from the Prader-Willi/Angelman syndrome region show monoallelic expression in fetal brain. N/A N/A N/A N/A Human N/A N/A 17337158 C1QTNF9B-AS1 prostate cancer Expression "PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET." N/A N/A N/A N/A Human N/A BC073902 15930275 CASC2 endometrial cancer Mutation "CASC2, in a region of common allelic loss at chromosome 10q26 is a novel candidate gene in human endometrial cancer." chr10 118046821 118210153 + Human C10orf5 NR_026939 15024726 CBR3-AS1 esophageal squamous cell carcinoma Expression Upregulation of the long non-coding RNA PlncRNA-1 promotes esophageal squamous carcinoma cell proliferation and correlates with advanced clinical stage. chr21 36131767 36156308 - Human PlncRNA-1; PlncRNA1 NR_038894 24337686 CBR3-AS1 prostate cancer Regulation Oncogene; putative therapeutic target chr21 36131767 36156308 - Human PlncRNA-1; PlncRNA1 NR_038894 24373479 CBR3-AS1 prostate cancer Interaction The prostate cancer-up-regulated long noncoding RNA PlncRNA-1 (CBR3-AS1) modulates apoptosis and proliferation through reciprocal regulation of androgen receptor. chr21 36131767 36156308 - Human PlncRNA-1; PlncRNA1 NR_038894 22264502 CCAT1 colorectal cancer Expression "Recently, colon cancer associated transcript 1 (CCAT1) lncRNA was found to be expressed in colorectal cancer (CRC) tumors but not in normal tissue." chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 23416875 CCAT1 gastric cancer Expression "Another study reported that lncRNA CCAT1 was up-regulated in gastric carcinoma tissues, and its expression was closely related to the transcription factor c-Myc." chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 24833871 CCAT1 gastric cancer Expression "Level of lncRNA CCAT1 was markedly increased in gastric carcinoma tissue comparing with normal tissue, and overexpressed CCAT1 promoted cancer cell proliferation and migration" chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 24757675 CCAT1 gastric cancer Regulation "Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma." chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 23143645 CCAT2 breast cancer Expression "CCAT2, a novel long non-coding RNA in breast cancer." chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 24077681 CCAT2 non-small cell lung cancer Regulation CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer. chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 24504682 CCDC26 glioma Mutation "In the pooled analysis, the odds ratio for low-grade glioma associated with rs55705857 was 4.3 (P = 2.31 ?10(-94)). rs55705857 maps to a highly evolutionarily conserved sequence within the long non-coding RNA CCDC26 raising the possibility of direct functionality. " chr8 129351694 129680239 - Human RAM NR_130917 23399484 CDKN2B-AS1 abdominal aortic aneurysm Mutation "Genetic risk (rs10757278, A>G) for abdominal aortic aneurysm." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 21146954 CDKN2B-AS1 acute lymphoblastic leukemia Expression Higher p15AS levels were often found in acute lymphoblastic (ALL) and myeloid leukemias (AML). chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 21874119 CDKN2B-AS1 acute lymphoblastic leukemia Expression Higher p15AS levels were often found in acute lymphoblastic (ALL) and myeloid leukemias (AML). chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 21874119 CDKN2B-AS1 acute lymphoblastic leukemia Mutation "rs564398 (A>G), mapping to the CDKN2BAS locus that encodes for ANRIL antisense non-coding RNA, showed a statistically significant correlation with the ALL phenotype, with a risk pattern that was compatible with an overdominant model of disease susceptibility." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 21414664 CDKN2B-AS1 Alzheimer's disease Mutation "Recent studies showed that single nucleotide polymorphisms (rs3217992, A>G;rs1063192, C>T) mapping in the vicinity of ANRIL are linked to a wide spectrum of conditions, including cardiovascular disease, ischemic stroke, type 2 diabetes, frailty and Alzheimer's disease." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 18761660 CDKN2B-AS1 Alzheimer's disease Mutation Genetic variation in lncRNA genes causes disease and influences susceptibility chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23791884 CDKN2B-AS1 aortic aneurysm Expression "Significantly reduced expression of all INK4/ARF transcripts (p15(INK4b), p16(INK4a), ARF and ANRIL) was found in PBTL of individuals harboring a common SNP (rs10757278) associated with increased risk of coronary artery disease, stroke and aortic aneurysm." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 19343170 CDKN2B-AS1 atherosclerosis Mutation Genetic variation in lncRNA genes causes disease and influences susceptibility chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23791884 CDKN2B-AS1 atherosclerosis Expression "9p21.3 may promote atherosclerosis by regulating expression of ANRIL, which in turn is associated with altered expression of genes controlling cellular proliferation pathways." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 19592466 CDKN2B-AS1 atherosclerosis Expression ANRIL expression is associated with atherosclerosis risk. Expression of ANRIL transcripts was directly correlated with severity of atherosclerosis. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20056914 CDKN2B-AS1 atherosclerosis Expression Gene expression studies have found that expression levels of CDKN2A/CDKN2B/ANRIL are co-regulated and associated with the risk haplotype and atherosclerosis severity. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 21550161 CDKN2B-AS1 atherosclerosis Expression abundantly expressed in atherosclerotic lesions. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20637465 CDKN2B-AS1 atherosclerosis Interaction ANRIL DQ485454 which is not genetically determined by the 9p21 genotype was significantly correlated with MTAP expression. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20637465 CDKN2B-AS1 atherosclerosis Locus A genetic susceptibility locus. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 atherosclerosis Mutation "Genotypes of rs10757278 linked to increased risk of atherosclerotic diseases are also associated with decreased expression in PBTL of the INK4/ARF locus, near CDKN2B-AS1 locus." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 19343170 CDKN2B-AS1 atherosclerosis Mutation "Individuals homozygous for the atherosclerotic risk allele (rs3217992, A>G;rs1063192, C>T) show decreased expression of ANRIL." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 21151960 CDKN2B-AS1 atherosclerosis Mutation The risk alleles for atherosclerosis-related phenotypes were consistently associated with a lower expression of ANRIL when evaluating exons 1-2. Common carotid artery stenosis was associated with a significantly lower (P<0.01) expression of ANRIL (exons 1-2). ANRIL knock-down in VSMC caused significant variation in expression of CDKN2A/B (P<0.05) and reduction of cell growth (P<0.05) in vitro. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 22178423 CDKN2B-AS1 atherosclerosis Mutation/Expression Transcripts EU741058 and NR_003529 of antisense noncoding RNA in the INK4 locus (ANRIL) were significantly increased in carriers of the risk haplotype. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20056914 CDKN2B-AS1 basal cell carcinoma Locus A genetic susceptibility locus. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 basal cell carcinoma Mutation "More recent GWAS also identified ANRIL as a risk locus (rs3217992, A>G;rs1063192, C>T) for gliomas and basal cell carcinomas in accordance with the princeps observation." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 breast cancer Expression Expression of ANRIL mainly coclustered with p14/ARF both in physiologic (various normal human tissues) and in pathologic conditions (human breast tumors). chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 17440112 CDKN2B-AS1 breast cancer Locus A genetic susceptibility locus. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 breast cancer Locus A locus associated with breast cancer. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20453838 CDKN2B-AS1 breast cancer Mutation "More recently, additional GWAS identified ANRIL as a risk locus (rs3217992, A>G;rs1063192, C>T) for several cancers including breast cancer, nasopharyngeal carcinoma, basal cell carcinoma, and glioma." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 cancer Expression Down-regulated in cells were incubated in the presence of BLM for 24 h or irradiated. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 22487937 CDKN2B-AS1 cancer Interaction "RNA immunoprecipitation demonstrates that ANRIL binds to SUZ12 in vivo. Collectively, these results suggest a model in which ANRIL binds to and recruits PRC2 to repress the expression of p15(INK4B) locus." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 21151178 CDKN2B-AS1 cancer Expression High expression of ANRIL has been found in certain cancer tissues such as melanoma and prostate cancers. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24757675 CDKN2B-AS1 cancer Locus "Furthermore, genome wide association studies have identified the ANRIL gene as a risk locus for coronary disease, intracranial aneurism, type 2 diabetes and several cancers including glioma. " chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24624135 CDKN2B-AS1 cancer Regulation "It has also been shown that the tumor suppressor gene p15 is silenced by its natural antisense RNA, a lncRNA ANRIL." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24829860 CDKN2B-AS1 cancer Expression "ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23104877 CDKN2B-AS1 cancer Expression "Another lncRNA associated with human cancers is ANRIL, a long, antisense transcript found in the INK4a/Arf locus. ANRIL is overexpressed in human leukemias and prostate cancers, and its expression leads to epigenetic silencing of the nearby tumor suppressor p15 (Yu et al., 2008; Yap et al., 2010). " chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23473599 CDKN2B-AS1 cardiovascular disease Mutation Aberrant ANRIL transcripts and mutations were associated with cardiovascular disease and cancer . chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24531795 CDKN2B-AS1 cardiovascular disease Mutation "Recent studies showed that single nucleotide polymorphisms (rs3217992, A>G;rs1063192, C>T) mapping in the vicinity of ANRIL are linked to a wide spectrum of conditions, including cardiovascular disease, ischemic stroke, type 2 diabetes, frailty and Alzheimer's disease." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20716961 CDKN2B-AS1 cardiovascular disease Expression "ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23104877 CDKN2B-AS1 cardiovascular disease Mutation Aberrant ANRIL transcripts and mutations were associated with cardiovascular disease and cancer . chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24531795 CDKN2B-AS1 cardiovascular disease Regulation "Recently, ANRIL, a multi-exonic lncRNA, has been shown to be implicated in epigenetic modulation in cardiac development and adult heart and also it has been associated with a locus implicated in cardiovascular disease." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24113581 CDKN2B-AS1 coronary artery disease Expression "Significantly reduced expression of all INK4/ARF transcripts (p15(INK4b), p16(INK4a), ARF and ANRIL) was found in PBTL of individuals harboring a common SNP (rs10757278) associated with increased risk of coronary artery disease, stroke and aortic aneurysm." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 19343170 CDKN2B-AS1 coronary artery disease Expression Whole blood RNA expression of the short variants of ANRIL was increased by 2.2-fold whereas expression of the long ANRIL variant was decreased by 1.2-fold in healthy subjects homozygous for the risk allele. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 19592466 CDKN2B-AS1 coronary artery disease Expression "Whole blood RNA expression of the short variants of ANRIL was increased by 2.2-fold whereas expression of the long ANRIL variant was decreased by 1.2-fold in healthy subjects homozygous for the risk allele. Expression levels of the long and short ANRIL variants were positively correlated with that of the cyclin-dependent kinase inhibitor, CDKN2B (p15) and TDGF1 (Cripto), respectively." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 19592466 CDKN2B-AS1 coronary artery disease Mutation "Sequence polymorphisms in a 58-kilobase (kb) interval on chromosome 9p21 confer a markedly increased risk (rs3217992, A>G;rs1063192, C>T) of coronary artery disease (CAD), the leading cause of death worldwide." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 17554300 CDKN2B-AS1 coronary artery disease Mutation "Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs (rs2891168, A>G) in the ANRIL locus on chromosome 9p." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 18048406 CDKN2B-AS1 coronary artery disease Expression "However, overexpression of 1 ANRIL variant altered the expression of many genes involved in nuclear regulation and chromatin architecture, indicating diverse trans-regulatory effects that go beyond the cis-effects seen at 9p21." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23104877 CDKN2B-AS1 coronary artery disease Locus A genetic susceptibility locus chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 coronary artery disease Mutation "Common disease genome wide association studies (GWAS) have surprisingly identified the ANRIL gene as a genetic susceptibility locus (rs3217992, A>G;rs1063192, C>T) shared associated by coronary disease, intracranial aneurysm and also type 2 diabetes." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 coronary artery disease Mutation "Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of ANRIL." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20386740 CDKN2B-AS1 coronary artery disease Mutation "Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of CDKN2B-AS1." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20386740 CDKN2B-AS1 coronary artery disease Locus "Furthermore, genome wide association studies have identified the ANRIL gene as a risk locus for coronary disease, intracranial aneurism, type 2 diabetes and several cancers including glioma. " chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24624135 CDKN2B-AS1 coronary heart disease Locus "CHD and periodontitis are genetically related by at least one susceptibility locus, which is possibly involved in ANRIL activity and independent of diabetes associated risk variants within this region. Elucidation of the interplay of ANRIL transcript variants and their involvement in increased susceptibility to the interactive diseases CHD and periodontitis promises new insight into the underlying shared pathogenic mechanisms of these complex common diseases." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 19214202 CDKN2B-AS1 coronary heart disease Mutation "Association of a genetic susceptibility locus (rs2891168, A>G;rs1333042, A>G;rs1333048, A>C)." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 19214202 CDKN2B-AS1 coronary heart disease Mutation "Association identified by GWAS (rs10757274, A>G;rs2383206, A>G)." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 17478681 CDKN2B-AS1 diabetes mellitus Mutation Genetic variation in lncRNA genes causes disease and influences susceptibility chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23791884 CDKN2B-AS1 diabetes mellitus Mutation "Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of CDKN2B-AS1." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20386740 CDKN2B-AS1 diabetes mellitus Expression "ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23104877 CDKN2B-AS1 endometriosis Mutation "The authors identified a significant association of endometriosis with rs10965235 (A>C, P = 5.57 x 10(-12), odds ratio = 1.44), which is located in CDKN2BAS on chromosome 9p21, encoding the cyclin-dependent kinase inhibitor 2B antisense RNA.the SNP showing the strongest association was located in intron 16 of CDKN2BAS and was implicated in regulating the expression of p15, p16 and p14." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20601957 CDKN2B-AS1 endometriosis Expression "ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23104877 CDKN2B-AS1 esophageal squamous cell carcinoma Regulation ANRIL inhibits p15INK4b through the TGFβ1 signaling pathway in human esophageal squamous cell carcinoma. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24747824 CDKN2B-AS1 intracranial aneurysm Mutation All 6 index cases from IA families had the rs1333040-T allele (C>T) in CDKN2BAS. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20395613 CDKN2B-AS1 frailty Mutation "Recent studies showed that single nucleotide polymorphisms (rs3217992, A>G;rs1063192, C>T) mapping in the vicinity of ANRIL are linked to a wide spectrum of conditions, including cardiovascular disease, ischemic stroke, type 2 diabetes, frailty and Alzheimer's disease." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 17459456 CDKN2B-AS1 gastric cancer Regulation Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24810364 CDKN2B-AS1 glaucoma Mutation Genetic variation in lncRNA genes causes disease and influences susceptibility chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23791884 CDKN2B-AS1 glaucoma Mutation "Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1 (rs4977756, A>G)." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 21532571 CDKN2B-AS1 glaucoma Expression "ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms, and it has been consistently associated with cardiovascular disease, and more recently with several cancers, diabetes, glaucoma, endometriosis among other conditions." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23104877 CDKN2B-AS1 glaucoma Mutation CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23111177 CDKN2B-AS1 glioma Mutation Genetic variation in lncRNA genes causes disease and influences susceptibility chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23791884 CDKN2B-AS1 glioma Locus A genetic susceptibility locus. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 glioma Mutation Association identified by GWAS. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 19578367 CDKN2B-AS1 glioma Mutation "More recent GWAS also identified ANRIL as a risk locus (rs3217992, A>G;rs1063192, C>T) for gliomas and basal cell carcinomas in accordance with the princeps observation." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 glioma Mutation "Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of ANRIL." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20386740 CDKN2B-AS1 glioma Mutation "Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of CDKN2B-AS1." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20386740 CDKN2B-AS1 glioma Mutation "Variants (rs1412829, C>T) in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 19578366 CDKN2B-AS1 hereditary cutaneous malignant melanoma N/A "Long ncRNA antisense non-coding RNA in the INK4 locus (ANRIL) has been associated to hereditary cutaneous malignant melanoma, prostate cancer and tumors of the neural system (Pasmant et al., 2011). " chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24624135 CDKN2B-AS1 intracranial aneurysm Locus "Furthermore, genome wide association studies have identified the ANRIL gene as a risk locus for coronary disease, intracranial aneurism, type 2 diabetes and several cancers including glioma. " chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24624135 CDKN2B-AS1 intracranial aneurysm Mutation Genetic variation in lncRNA genes causes disease and influences susceptibility chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23791884 CDKN2B-AS1 intracranial aneurysm Locus A genetic susceptibility locus. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 intracranial aneurysm Locus We also confirmed prior associations near CDKN2A-CDKN2B locus. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20364137 CDKN2B-AS1 intracranial aneurysm Mutation "Association identified by GWAS (rs1333040, C>T)." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 18997786 CDKN2B-AS1 intracranial aneurysm Mutation "Common disease genomewide association studies (GWAS) have surprisingly identified the ANRIL gene as a genetic susceptibility locus (rs3217992, A>G;rs1063192, C>T)shared associated by coronary disease, intracranial aneurysm and also type 2 diabetes." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 ischemic stroke Regulation Regulation of CARD8 expression by ANRIL and association of CARD8 single nucleotide polymorphism rs2043211 (p.C10X) with ischemic stroke. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24385277 CDKN2B-AS1 leukemia Regulation Gene silencing of INK4b-ARF-INK4a and p15/CDKN2B by recruitment of PRC1 and PRC2. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 22996375 CDKN2B-AS1 melanoma Locus A genetic susceptibility locus. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 melanoma Mutation A large germline deletion (403231 bp) encompassing the INK4/ARF locus and the ANRIL lncRNA has been associated with hereditary cutaneous malignant melanoma (CMM) and neural system tumors (NST) syndrome. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 21550244 CDKN2B-AS1 melanoma Mutation Association identified by GWAS. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 17440112 CDKN2B-AS1 melanoma Mutation "Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of ANRIL." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20386740 CDKN2B-AS1 melanoma Mutation "Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of CDKN2B-AS1." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20386740 CDKN2B-AS1 myocardial infarction Mutation Association identified by GWAS. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 17478679 CDKN2B-AS1 myocardial infarction Mutation "association identified by GWAS (rs4977574, A>G)." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 19198609 CDKN2B-AS1 nasopharyngeal carcinoma Locus A genetic susceptibility locus. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 nasopharyngeal carcinoma Mutation A SNP rs1412829 (C49137T) at CDKN2A-CDKN2B gene cluster on 9p21 is associated with this disease. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20512145 CDKN2B-AS1 nasopharyngeal carcinoma Mutation "More recently, additional GWAS identified ANRIL as a risk locus (rs3217992, A>G;rs1063192, C>T) for several cancers including breast cancer, nasopharyngeal carcinoma, basal cell carcinoma, and glioma." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 nasopharyngeal carcinoma Mutation "In recent years, GWAS has identified ANRIL as a risk locus for NPC and other cancers." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24817925 CDKN2B-AS1 neural system tumors syndrome Mutation A large germline deletion (403231 bp) encompassing the INK4/ARF locus and the ANRIL lncRNA has been associated with hereditary cutaneous malignant melanoma (CMM) and neural system tumors (NST) syndrome. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 21550244 CDKN2B-AS1 neurofibromatosis Mutation "Single-nucleotide polymorphism rs2151280 (C>T, located in ANRIL) was statistically significantly associated with the number of PNFs (P < .001) in NF1 patients. In addition, allele T of rs2151280 was statistically significantly associated with reduced ANRIL transcript levels (P < .001), suggesting that modulation of ANRIL expression mediates PNF susceptibility." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 22034633 CDKN2B-AS1 periodontitis Locus "CHD and periodontitis are genetically related by at least one susceptibility locus, which is possibly involved in ANRIL activity and independent of diabetes associated risk variants within this region. Elucidation of the interplay of ANRIL transcript variants and their involvement in increased susceptibility to the interactive diseases CHD and periodontitis promises new insight into the underlying shared pathogenic mechanisms of these complex common diseases." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 19214202 CDKN2B-AS1 periodontitis Mutation "Association of a genetic susceptibility locus (rs2891168, A>G;rs1333042, A>G;rs1333048, A>C)." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 19214202 CDKN2B-AS1 peripheral artery disease Mutation SNP rs2383207 on ANRIL was most significantly associated with lower ABI. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 22122968 CDKN2B-AS1 plexiform neurofibroma Mutation Genetic variation in lncRNA genes causes disease and influences susceptibility chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23791884 CDKN2B-AS1 prostate cancer Regulation Gene silencing of INK4b-ARF-INK4a and p15/CDKN2B by recruitment of PRC1 and PRC2. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 22996375 CDKN2B-AS1 prostate cancer Regulation "ANRIL is an antisense lncRNA elevated in PCa that overlaps this locus, interacting directly with polycomb repressive complex 1 and histone H3K27 methylation to repress CDKN2A-CDKN2B expression" chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24146262 CDKN2B-AS1 prostate cancer Interaction "Here we report that chromobox 7 (CBX7) within the polycomb repressive complex 1 binds to ANRIL, and both CBX7 and ANRIL are found at elevated levels in prostate cancer tissues." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20541999 CDKN2B-AS1 prostate cancer N/A "Long ncRNA antisense non-coding RNA in the INK4 locus (ANRIL) has been associated to hereditary cutaneous malignant melanoma, prostate cancer and tumors of the neural system (Pasmant et al., 2011). " chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24624135 CDKN2B-AS1 prostate cancer Expression "ANRIL is upregulated in prostate cancer and is required for the repression of the tumor suppressors INK4a/p16 and INK4b/p15 (Yap et al., 2010; Kotake et al., 2011). " chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24721780 CDKN2B-AS1 prostate cancer Expression "ANRIL, also upregulated in prostate cancer, is required for the repression of the tumor suppressors INK4a/p16 and INK4b/p15." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23463798 CDKN2B-AS1 stroke Mutation Genetic variation in lncRNA genes causes disease and influences susceptibility chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23791884 CDKN2B-AS1 stroke Expression "Significantly reduced expression of all INK4/ARF transcripts (p15(INK4b), p16(INK4a), ARF and ANRIL) was found in PBTL of individuals harboring a common SNP (rs10757278) associated with increased risk of coronary artery disease, stroke and aortic aneurysm." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 19343170 CDKN2B-AS1 stroke Mutation "Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of ANRIL." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20386740 CDKN2B-AS1 stroke Mutation "Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of CDKN2B-AS1." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20386740 CDKN2B-AS1 stroke Mutation "Variants (rs3217992, A>G;rs1063192, C>T) on chromosome 9p21.3 correlated with ANRIL expression contribute to stroke risk and recurrence in a large prospective stroke population." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 22034006 CDKN2B-AS1 stroke Expression Levels of CDKN2B-AS1/ANRIL in human carotid atherosclerotic plaques and peripheral blood T lymphocytes are linked to rates of ischemic and hemorrhagic stroke. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24145019 CDKN2B-AS1 cancer Regulation "ANRIL, GAS5 and lincRNA-p23 are involved in the escape of growth suppression by regulating tumor suppressor genes (ANRIL) or apoptosis regulators." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24667321 CDKN2B-AS1 cancer N/A "Long ncRNA antisense non-coding RNA in the INK4 locus (ANRIL) has been associated to hereditary cutaneous malignant melanoma, prostate cancer and tumors of the neural system (Pasmant et al., 2011). " chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24624135 CDKN2B-AS1 type 2 diabetes mellitus Locus A genetic susceptibility locus. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 type 2 diabetes mellitus Mutation Association identified by GWAS. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 17463249 CDKN2B-AS1 type 2 diabetes mellitus Mutation "Common disease genomewide association studies (GWAS) have surprisingly identified the ANRIL gene as a genetic susceptibility locus (rs3217992, A>G;rs1063192, C>T) shared associated by coronary disease, intracranial aneurysm and also type 2 diabetes." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20956613 CDKN2B-AS1 type 2 diabetes mellitus Mutation "Recent studies showed that single nucleotide polymorphisms (rs3217992, A>G;rs1063192, C>T) mapping in the vicinity of ANRIL are linked to a wide spectrum of conditions, including cardiovascular disease, ischemic stroke, type 2 diabetes, frailty and Alzheimer's disease." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 17463248 CDKN2B-AS1 type 2 diabetes mellitus Mutation "Risk SNPs (rs3217992, A>G;rs1063192, C>T) for coronary disease, stroke, diabetes, melanoma, and glioma were all associated with allelic expression of ANRIL." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 20386740 CDKN2B-AS1 type 2 diabetes mellitus Mutation "Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs (rs2891168, A>G) in the ANRIL locus on chromosome 9p." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 18048406 CDKN2B-AS1 type 2 diabetes mellitus Locus "Furthermore, genome wide association studies have identified the ANRIL gene as a risk locus for coronary disease, intracranial aneurism, type 2 diabetes and several cancers including glioma. " chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24624135 CDKN2B-AS10 stroke Expression Genetic variants that affect the expression of the ANRIL transcript have been correlated with stroke risk and recurrence in a large prospective study N/A N/A N/A N/A Human N/A N/A 22817756 CDKN2B-AS11 stroke Mutation "Moreover, genome-wide association studies have demonstrated that the 9p21 genomic locus is a hotspot for the risk of stroke, glioma, plexiform neurofibroma and other disorders" N/A N/A N/A N/A Human N/A N/A 22814587 CDKN2B-AS12 glioma Mutation "Moreover, genome-wide association studies have demonstrated that the 9p21 genomic locus is a hotspot for the risk of stroke, glioma, plexiform neurofibroma and other disorders" N/A N/A N/A N/A Human N/A N/A 22814587 CDKN2B-AS13 plexiform neurofibroma Mutation "Moreover, genome-wide association studies have demonstrated that the 9p21 genomic locus is a hotspot for the risk of stroke, glioma, plexiform neurofibroma and other disorders" N/A N/A N/A N/A Human N/A N/A 22814587 CDKN2B-AS2 coronary heart disease Mutation "Interestingly, genome wide association studies (GWAS) identified several variants in the intergenic region encompassing ANRIL to be associated with several diseases such as coronary heart disease, intracranial aneurysm, many type of cancers and T2D" N/A N/A N/A N/A Human N/A N/A 22928560 CDKN2B-AS3 intracranial aneurysm Mutation "Interestingly, genome wide association studies (GWAS) identified several variants in the intergenic region encompassing ANRIL to be associated with several diseases such as coronary heart disease, intracranial aneurysm, many type of cancers and T3D" N/A N/A N/A N/A Human N/A N/A 22928560 CDKN2B-AS4 cancer Mutation "Interestingly, genome wide association studies (GWAS) identified several variants in the intergenic region encompassing ANRIL to be associated with several diseases such as coronary heart disease, intracranial aneurysm, many type of cancers and T4D" N/A N/A N/A N/A Human N/A N/A 22928560 CDKN2B-AS5 type 2 diabetes mellitus Mutation "Interestingly, genome wide association studies (GWAS) identified several variants in the intergenic region encompassing ANRIL to be associated with several diseases such as coronary heart disease, intracranial aneurysm, many type of cancers and T5D" N/A N/A N/A N/A Human N/A N/A 22928560 CDKN2B-AS6 neuroblastoma Expression "Disruptions to the expression of ANRIL have accordingly been associated with the development of several cancer types, including neuroblastoma , acute lymphocytic leukaemia, melanoma and prostate" N/A N/A N/A N/A Human N/A N/A 22817756 CDKN2B-AS7 acute lymphoblastic leukemia Expression "Disruptions to the expression of ANRIL have accordingly been associated with the development of several cancer types, including neuroblastoma , acute lymphocytic leukaemia, melanoma and prostate" N/A N/A N/A N/A Human N/A N/A 22817756 CDKN2B-AS8 melanoma Expression "Disruptions to the expression of ANRIL have accordingly been associated with the development of several cancer types, including neuroblastoma , acute lymphocytic leukaemia, melanoma and prostate" N/A N/A N/A N/A Human N/A N/A 22817756 CDKN2B-AS9 prostate cancer Expression "Disruptions to the expression of ANRIL have accordingly been associated with the development of several cancer types, including neuroblastoma , acute lymphocytic leukaemia, melanoma and prostate" N/A N/A N/A N/A Human N/A N/A 22817756 CECR3 cat eye syndrome N/A "Cat eye syndrome chromosome region, candidate 3" chr22 17256859 17266733 - Human N/A NR_038398 11381032 CHL1-AS2 adolescent idiopathic scoliosis Mutation "We found strongest evidence of association with chromosome 3p26.3 SNPs (rs1400180,A>C) in the proximity of the CHL1 gene (P < 8*10^(-8) for rs1400180)." chr3 112157 197407 - Human N/A NR_144486 21216876 CHRF cardiac hypertrophy Regulation The Long Noncoding RNA CHRF Regulates Cardiac Hypertrophy by Targeting miR-489. N/A N/A N/A N/A Human N/A N/A 24557880 CRNDE colorectal cancer Expression "An uncharacterized gene locus (Chr16:hCG_1815491), now named colorectal neoplasia differentially expressed (gene symbol CRNDE), is activated early in colorectal neoplasia." chr16 54845189 54929189 - Human CRNDE ENST00000613942 22393467 CTBP1-AS prostate cancer Regulation Oncogene chr4 1210120 1218591 + Human PCAT10 NR_104331 24373479 CTBP1-AS prostate cancer Regulation "The prostate cancer-associated ncRNA transcript 1 lncRNA PCAT1, SchlAP1 (second chromosome locus associated with prostate-1), and CTBP1-AS indicate cancer cell invasiveness and metastasis in prostate cancer progression. " chr4 1210120 1218591 + Human PCAT10 NR_104331 24531795 D4Z4 facioscapulohumeral muscular dystrophy Mutation "The genetic lesion involved in FSHD is unusual as it does not target a protein-coding gene, but rather affects the copy number of the 3.3 kb macrosatellite D4Z4 mapping at the subtelomeric region of chromosome 4 (4q35)." N/A N/A N/A N/A Human N/A N/A 24685002 DANCR bone diseases Expression "These data suggest that ANCR is an essential mediator of osteoblast differentiation, thus offering a new target for the development of therapeutic agents to treat bone diseases." chr4 52712454 52714138 + Human AGU2; ANCR; KIAA0114; SNHG13; lncRNA-ANCR NR_024031 23438432 DAOA-AS1 bipolar disorder Mutation "Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series." chr13 105459055 105505681 - Human DAOA-AS; DAOAAS; G30 NR_040247 12647258 DAOA-AS1 panic disorder N/A Panic disorder associated. chr13 105459055 105505681 - Human DAOA-AS; DAOAAS; G30 NR_040247 15477870 DAOA-AS1 schizophrenia Expression Markers of the G72/G30 genes are associated with schizophrenia in a non-Caucasian population. chr13 105459055 105505681 - Human DAOA-AS; DAOAAS; G30 NR_040247 15194506 DAOA-AS1 schizophrenia Mutation Meta-analysis revealed that there is weak evidence of association between the G72/G30 genes and schizophrenia. chr13 105459055 105505681 - Human DAOA-AS; DAOAAS; G30 NR_040247 17179078 DAOA-AS1 schizophrenia Mutation "Significant associations of schizophrenia with the A allele of rs947267 (A>C,P=0.012) and haplotype A-A-G (rs2391191-rs947267-rs778294) (P=0.008) were found in early-onset schizophrenic patients." chr13 105459055 105505681 - Human DAOA-AS; DAOAAS; G30 NR_040247 17179866 DAOA-AS1 schizophrenia Mutation "Transmission disequilibrium analysis revealed a significant association between the rs947267 polymorphism (A>C) and schizophrenia (P=0.016), with the A allele more commonly transmitted to patients." chr13 105459055 105505681 - Human DAOA-AS; DAOAAS; G30 NR_040247 16791105 DAOA-AS1 schizophrenia Mutation "rs778294 (A>G) and rs947267 (A>C), were found to be associated with the risk of schizophrenia." chr13 105459055 105505681 - Human DAOA-AS; DAOAAS; G30 NR_040247 17651942 DAOA-AS1 schizophrenia N/A Association with schizophrenia. chr13 105459055 105505681 - Human DAOA-AS; DAOAAS; G30 NR_040247 15271585 DAOA-AS1 schizophrenia N/A G72/G30 (DAOA-AS1) are important candidate genes for explaining schizophrenia in the Han Chinese population. chr13 105459055 105505681 - Human DAOA-AS; DAOAAS; G30 NR_040247 15653269 DAOA-AS1 schizophrenia N/A G72/G30 genes are involved in conferring susceptibility to schizophrenia. chr13 105459055 105505681 - Human DAOA-AS; DAOAAS; G30 NR_040247 16402132 DBET facioscapulohumeral muscular dystrophy Expression "As a result, this region becomes more prone to transcription and gives rise to the activatory lncRNA DBE-T. DBE-T is mainly produced in FSHD patients and mediates the aberrant activation of the FSHD locus." chr4 190064502 190067864 + Human DBE-T; DUX4L30 NR_121644 24685002 DBET facioscapulohumeral muscular dystrophy Regulation Epigenetic deregulation of lncRNAs genes is associated with disease chr4 190064502 190067864 + Human DBE-T; DUX4L30 NR_121644 23791884 DBET facioscapulohumeral muscular dystrophy Mutation The activatory long non-coding RNA DBE-T reveals the epigenetic etiology of facioscapulohumeral muscular dystrophy. chr4 190064502 190067864 + Human DBE-T; DUX4L30 NR_121644 22710800 DBET facioscapulohumeral muscular dystrophy Regulation "In contrast, in FSHD patients, a deletion of D4Z4 repeats results in cis production of the DBE-T lncRNA that binds to protein complexes, reorganizes the chromatin state of the FSHD locus, and reactivates the repressed 4q35 genes." chr4 190064502 190067864 + Human DBE-T; DUX4L30 NR_121644 24667321 DGCR5 DiGeorge syndrome Expression "The DiGeorge syndrome-associated noncoding RNA, DGCR5, is repressed by REST through a proximal upstream binding site." chr22 18970498 19031242 + Human LINC00037; NCRNA00037 NR_110533 19050060 DGCR5 DiGeorge syndrome Mutation DGCR5 is disrupted by the patient ADU breakpoint. chr22 18970498 19031242 + Human LINC00037; NCRNA00037 NR_110533 8659529 DGCR5 Huntington's disease Expression "Interestingly, many of these lncRNAs contain genomic binding sites for the transcriptional repressor REST, a key mediator of transcriptional changes in HD, including the known REST target lncRNA, DGCR5." chr22 18970498 19031242 + Human LINC00037; NCRNA00037 NR_110533 23346095 DGCR5 velocardiofacial syndrome N/A Association chr22 18970498 19031242 + Human LINC00037; NCRNA00037 NR_110533 20380817 DISC2 affective disorder N/A DISC2 is a likely susceptibility locus for both schizophrenia and affective disorders. chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 15478311 DISC2 autism spectrum disorder Regulation Genomic context links lncRNAs to disease genes/loci and related pathways chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 23791884 DISC2 autism spectrum disorder Locus "The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders." chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 19606485 DISC2 autism spectrum disorder Regulation "DISC1 is regulated by its lncRNA, DISC6, which may also represent an excellent candidate for susceptibility to these disorders." chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 22817756 DISC2 bipolar disorder Regulation Genomic context links lncRNAs to disease genes/loci and related pathways chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 23791884 DISC2 bipolar disorder Locus "The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders." chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 17912248 DISC2 bipolar disorder Regulation "DISC1 is regulated by its lncRNA, DISC4, which may also represent an excellent candidate for susceptibility to these disorders." chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 22817756 DISC2 depression Locus "The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders." chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 17912248 DISC2 major depressive affective disorder Regulation Genomic context links lncRNAs to disease genes/loci and related pathways chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 23791884 DISC2 major depressive affective disorder Regulation "DISC1 is regulated by its lncRNA, DISC5, which may also represent an excellent candidate for susceptibility to these disorders." chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 22817756 DISC2 schizophrenia Locus "The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders." chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 20380817 DISC2 schizophrenia Regulation "DISC1 is regulated by its lncRNA, DISC3, which may also represent an excellent candidate for susceptibility to these disorders." chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 22817756 DISC2 schizophrenia Mutation "The Disrupted in Schizophrenia (DISC) locus on human chromosome 1q42 has been strongly implicated by genetic studies as a susceptibility locus for major mental illnesses.DISC2, a putative noncoding transcript partially antisense to DISC1, is not conserved." chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 12573262 DISC2 schizophrenia Regulation Genomic context links lncRNAs to disease genes/loci and related pathways chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 23791884 DISC2 schizophrenia Locus DISC2 should be considered a formal candidate gene for susceptibility to psychiatric illness (schizophrenia). chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 10814723 DISC2 schizophrenia Locus "The disruption of the DISC genomic locus, which encodes both the DISC1 protein-coding gene and the DISC2 lncRNA, has been linked in a number of genetic analyses to the risk of developing schizophrenia, schizophrenia, bipolar disorder, major depression, and autistic spectrum disorders." chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 17912248 DISC2 schizophrenia N/A DISC1 and DISC2 should be considered formal candidate genes for susceptibility to psychiatric illness. chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 10814723 DISC2 schizophrenia N/A DISC2 is a likely susceptibility locus for both schizophrenia and affective disorders. chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 15478311 DISC2 schizophrenia Regulation "DISC1 is regulated by its lncRNA, DISC2, which may also represent an excellent candidate for susceptibility to these disorders. " chr1 231814626 231818517 - Human DISC1-AS1; DISC1OS; NCRNA00015 NR_002227 22817756 DLEU1 chronic lymphocytic leukemia Locus "In 13q14.3, where several tumor suppressor genes, including the miRNA genes miR-16-1 and miR-15a, are co-regulated by the two long non-coding RNA genes DLEU1 and DLEU2 that span the critical region." chr13 50082169 50528643 + Human BCMS; BCMS1; DLB1; DLEU2; LEU1; LEU2; LINC00021; NCRNA00021; XTP6 NR_109973 19347735 DLEU1 chronic lymphocytic leukemia Mutation Frequently deleted in B-cell chronic lymphocytic leukemia. chr13 50082169 50528643 + Human BCMS; BCMS1; DLB1; DLEU2; LEU1; LEU2; LINC00021; NCRNA00021; XTP6 NR_109973 11161783 DLEU1 chronic lymphocytic leukemia N/A Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis. chr13 50082169 50528643 + Human BCMS; BCMS1; DLB1; DLEU2; LEU1; LEU2; LINC00021; NCRNA00021; XTP6 NR_109973 9395242 DLEU1 chronic lymphocytic leukemia Expression "The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way." chr13 50082169 50528643 + Human BCMS; BCMS1; DLB1; DLEU2; LEU1; LEU2; LINC00021; NCRNA00021; XTP6 NR_109973 19591824 DLEU1 chronic lymphocytic leukemia Locus "In 13q14.3, where several tumor suppressor genes, including the miRNA genes miR-16-1 and miR-15a, are co-regulated by the two long non-coding RNA genes DLEU1 and DLEU2 that span the critical region." chr13 50082169 50528643 + Human BCMS; BCMS1; DLB1; DLEU2; LEU1; LEU2; LINC00021; NCRNA00021; XTP6 NR_109973 19347735 DLEU1 chronic lymphocytic leukemia Mutation B-cell chronic lymphocytic leukemia: frequent chromosomal imbalance. chr13 50082169 50528643 + Human BCMS; BCMS1; DLB1; DLEU2; LEU1; LEU2; LINC00021; NCRNA00021; XTP6 NR_109973 11072235 DLEU1 chronic lymphocytic leukemia Mutation Frequently deleted in B-cell chronic lymphocytic leukemia. chr13 50082169 50528643 + Human BCMS; BCMS1; DLB1; DLEU2; LEU1; LEU2; LINC00021; NCRNA00021; XTP6 NR_109973 11161783 DLEU1 chronic lymphocytic leukemia N/A Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis. chr13 50082169 50528643 + Human BCMS; BCMS1; DLB1; DLEU2; LEU1; LEU2; LINC00021; NCRNA00021; XTP6 NR_109973 9395242 DLEU1 lymphocytic leukemia Locus "Dleu2 is an antisense transcript that encompasses the Kcnrg and Trim13 genes, as well as two microRNA genes, Mirn16-1 and Mirn15a, which have been previously identified in lymphocytic leukemia." chr13 50082169 50528643 + Human BCMS; BCMS1; DLB1; DLEU2; LEU1; LEU2; LINC00021; NCRNA00021; XTP6 NR_109973 18562676 DLEU1 lymphoma Expression "The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way." chr13 50082169 50528643 + Human BCMS; BCMS1; DLB1; DLEU2; LEU1; LEU2; LINC00021; NCRNA00021; XTP6 NR_109973 19591824 DLEU1 lymphoma Mutation mantle-cell lymphoma: frequent chromosomal imbalance. chr13 50082169 50528643 + Human BCMS; BCMS1; DLB1; DLEU2; LEU1; LEU2; LINC00021; NCRNA00021; XTP6 NR_109973 11072235 DLEU1 myeloma Expression "The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way." chr13 50082169 50528643 + Human BCMS; BCMS1; DLB1; DLEU2; LEU1; LEU2; LINC00021; NCRNA00021; XTP6 NR_109973 19591824 DLX6-AS1 split hand/split foot malformation disorder Interaction "The lncRNA EVF2, which recruits the transcription factor Dlx2 to activate the protein coding genes DLX5 and DLX6 that are associated with the Split Hand/ Split Foot malformation disorder." chr7 96968515 97014065 - Human DLX6-AS; DLX6AS; Evf-2; NCRNA00212 NR_015448 20930520 DNM3OS ovarian cancer Locus pri-miR-199a2 within the human Dnm3os gene. The regulation of MIR199A2/214 expression may be used as a potential therapeutic approach in EOC (epithelial ovarian cancer) patients. chr1 172136879 172144835 - Human DNM3-AS1; MIR199A2HG NR_038397 20400975 DQ786243 Crohn's disease Regulation LncRNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn's disease. N/A N/A N/A N/A Human N/A N/A 24289115 Dreh hepatocellular carcinoma Regulation "Further experiments showed that Dreh can specifically bind to vimentin, a type III intermediate filament and the major cytoskeletal component of mesenchymal cells and then inhibit HCC metastasis by modifying the expression and reorganization of vimentin. " chr17 64767111 64767931 + Mouse N/A NR_105051 24296588 Dreh hepatocellular carcinoma Regulation "lncRNA-Dreh could bind to the intermediate filament protein vimentin, repress its expression, and thus change the cytoskeleton structure and inhibit tumor metastasis. It acts as a tumor suppressor in the development of HBV-HCC, which inhibits HCC growth and metastasis in vitro and in vivo. These findings support a role of lncRNA-Dreh in tumor suppression and survival prediction of HCC patients." chr17 64767111 64767931 + Mouse N/A NR_105051 24757675 DSCAM-AS1 adolescent idiopathic scoliosis Mutation "Other top associations in our GWAS were with SNPs (rs2222973, C>T) in the DSCAM gene." chr21 40383083 40385358 + Human M41 NR_038900 21216876 DSCAM-AS1 breast cancer Expression M41 (DSCAM-AS1) mRNA is expressed at a statistically significantly higher level in human breast cancer specimens than in normal human breast and benign lesions. chr21 40383083 40385358 + Human M41 NR_038900 12177779 TTTY7 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chrY 6449468 6457906 + Human CLONE795723; LINC00129; NCRNA00129A; TTTY7B; TTY7; TTTY7 NR_001534 24603890 ENSG00000196096 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr2 213276552 213284205 - Human AC079610.1 ENST00000360083 24603890 LINC00336 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr6 33586106 33593338 - Human C6orf227; NCRNA00336 NR_027908 24603890 ENSG00000203325 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr1 32052291 32073474 - Human AL445248.1 ENST00000366152 24603890 ENSG00000206129 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr18 56003613 56191262 - Human AC006305.1 ENST00000589754 24603890 LINC01020 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr5 5034359 5070004 + Human N/A NR_026994 24603890 FAM66B hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr8 7301611 7355354 - Human FAM66E NR_027423 24603890 LINC01139 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr1 238480384 238486017 - Human LINK-A; LINKA NR_015407 24603890 LINC00323 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr21 41141500 41148064 - Human C21orf130; NCRNA00323; PRED42 NR_024100 24603890 LINC01204 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chrX 45505388 45527239 + Human N/A NR_104645 24603890 LINC01721 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr20 24199767 24224588 + Human N/A NR_040102 24603890 HAR1B hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr20 63095493 63102319 - Human HAR1R; LINC00065; NCRNA00065 NR_003245 24603890 ENSG00000231185 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr5 142325293 142672001 + Human AC010317.1 ENST00000443800 24603890 LEF1-AS1 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr4 108167525 108176430 + Human LEF1NAT NR_029374 24603890 LINC01798 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr2 66574030 66695588 + Human N/A NR_110156 24603890 SNHG15 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr7 44983028 44986660 - Human C7orf40; Linc-Myo1g; MYO1GUT NR_003697 24603890 LINC01762 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr1 116423724 116478826 - Human N/A NR_125973 24603890 ENSG00000233251 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr2 56173534 56185770 - Human AC007743.1 ENST00000447423 24603890 SMIM2-IT1 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr13 44146470 44158222 - Human C13orf44-IT1 NR_046843 24603890 SNHG6 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr8 66921930 66925542 - Human HBII-276HG; NCRNA00058; U87HG NR_002599 24603890 ENSG00000248176 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr4 29118308 29202770 + Human AC109349.1 ENST00000503299 24603890 ENSG00000249364 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr5 67379378 67805238 + Human AC112206.2 ENST00000509947 24603890 ENSG00000249772 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr5 81113385 81114852 - Human AC026427.1 ENST00000508993 24603890 ENSG00000250195 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr4 138819954 139012646 - Human AC109927.1 ENST00000507038 24603890 ENSG00000250608 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr3 131325092 131381475 - Human AC010210.1 ENST00000441345 24603890 ENSG00000254154 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr1 177928788 178038007 - Human AL359075.2 ENST00000464428 24603890 ENSG00000255471 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr11 86892214 86925037 - Human AP001528.2 ENST00000533672 24603890 ENSG00000256218 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr12 5366048 5367774 - Human AC007848.2 ENST00000543308 24603890 LINC00929 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr15 26115813 26133037 + Human N/A NR_038852 24603890 LINC00667 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr18 5238100 5246508 + Human N/A NR_015389 24603890 ENSG00000264772 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr17 7572826 7582024 + Human AC016876.2 ENST00000581621 24603890 LINC01538 hereditary haemorrhagic telangiectasia Expression Top 42 long non-coding RNAs (q<0.001) differentially expressed in HHT telangiectasia. chr18 64213082 64260055 - Human N/A NR_033983 24603890 Tdpx-ps1 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 30 downregulated in HF hearts as compared with control hearts. N/A N/A N/A N/A Mouse N/A N/A 24205036 Gm15054 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 15 downregulated in HF hearts as compared with control hearts. chr6 52357544 52357824 - Mouse N/A ENSMUST00000117393 24205036 Gm12919 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 24 downregulated in HF hearts as compared with control hearts. chr4 10853843 10855436 + Mouse N/A ENSMUST00000119855 24205036 Gm7327 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 14 downregulated in HF hearts as compared with control hearts. chrX 61785381 61786032 + Mouse N/A ENSMUST00000120925 24205036 Gm14155 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 8 downregulated in HF hearts as compared with control hearts. chr2 151829067 151832108 + Mouse N/A ENSMUST00000127230 24205036 Gm10371 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 27 downregulated in HF hearts as compared with control hearts. chr14 47097679 47116161 - Mouse N/A NR_126579 24205036 SMAD1-AS1 ventricular septal defects Expression "Furthermore, our established filtering pipeline indicated an association of two lncRNAs, ENST00000513542 and RP11-473L15.2, with VSD. " chr4 145514578 145517194 - Human N/A NR_126371 24147006 EPB41L4A-AS1 cancer Expression Ectopic expression of TIGA1 (EPB41L4A-AS1) inhibited not only tumor cell proliferation but also anchorage-independent growth of cancer cell lines. chr5 112160526 112162501 + Human C5orf26; NCRNA00219; TIGA1 NR_015370 16973895 CASC9 esophageal squamous cell carcinoma Expression "In addition, we confirmed another two upregulated lncRNAs that are differentially expressed in ESCC and that we have named ESCCAL-1, and ESCCAL-5." chr8 75223117 75278889 - Human ESCCAL-1; ESSCAL1; LINC00981 NR_103848 24222893 ESCCAL-5 esophageal squamous cell carcinoma Expression "In addition, we confirmed another two upregulated lncRNAs that are differentially expressed in ESCC and that we have named ESCCAL-1, and ESCCAL-5." N/A N/A N/A N/A Human N/A N/A 24222893 ESRG embryonal carcinoma Expression "HESRG was expressed strongly and diffusively in the nuclei of tumor cells in intracranial germinoma and embryonal carcinoma as well as in human embryonic stem cells.In embryonal carcinoma, 6 of 9 showed intensive (3+) immunostaining and 3 of 9 showed moderate (2+) immunostaining." chr3 54632124 54639857 - Human HESRG NR_027122 21861197 ESRG intracranial aneurysm Expression "HESRG was expressed strongly and diffusively in the nuclei of tumor cells in intracranial germinoma and embryonal carcinoma as well as in human embryonic stem cells.In germinomas, 25 of 31 showed intensive (3+) expression, four cases showed moderate (2+) immunostaining and the remaining 2 cases showed weak (1+) immunostaining." chr3 54632124 54639857 - Human HESRG NR_027122 21861197 Fendrr heart failure Expression The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. chr8 121054882 121083110 - Mouse 1110050K14Rik; LL66; linc-Foxf1a; lincFoxf1 NR_045471 23369715 FGF10-AS1 ventricular septal defects Expression "Furthermore, our established filtering pipeline indicated an association of two lncRNAs, ENST00000513542 and RP11-473L15.2, with VSD. " chr5 44388732 44413989 + Human N/A NR_108034 24147006 FMR1-AS1 fragile X syndrome Regulation Genomic context links lncRNAs to disease genes/loci and related pathways chrX 147909431 147911817 - Human ASFMR1; FMR1-AS; FMR1AS; FMR4 NR_024499 23791884 FMR1-AS1 fragile X syndrome Expression A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome. chrX 147909431 147911817 - Human ASFMR1; FMR1-AS; FMR1AS; FMR4 NR_024499 18213394 FMR1-AS1 fragile X syndrome Expression FMR4 is also silenced in FXS patients because of a CGG expansion repeat in the 5'-untranslated region (UTR) of the FMR1 gene and up regulated in pre-mutation carriers chrX 147909431 147911817 - Human ASFMR1; FMR1-AS; FMR1AS; FMR4 NR_024499 18213394 FMR1-AS1 fragile X-associated tremor and ataxia syndrome Regulation Genomic context links lncRNAs to disease genes/loci and related pathways chrX 147909431 147911817 - Human ASFMR1; FMR1-AS; FMR1AS; FMR4 NR_024499 23791884 FMR5 fragile X syndrome Expression Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome. N/A N/A N/A N/A Human N/A N/A 24005575 FMR5 fragile X-associated tremor and ataxia syndrome Expression Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome. N/A N/A N/A N/A Human N/A N/A 24005575 FMR6 fragile X syndrome Expression Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome. N/A N/A N/A N/A Human N/A N/A 24005575 FMR6 fragile X-associated tremor and ataxia syndrome Expression Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome. N/A N/A N/A N/A Human N/A N/A 24005575 GAS5 autoimmune disease Expression Increased lncRNA Gas5 activity in immune cells could suppress GR-induced transcriptional activity and contribute to the development of autoimmune disease. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 20124551 GAS5 B-cell neoplasms Expression "HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 24583225 GAS5 breast cancer Expression "GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 18836484 GAS5 breast cancer Expression Gas5 has also been linked with breast cancer because Gas5 transcript levels are significantly reduced compared to unaffected normal breast epithelia. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 20673990 GAS5 breast cancer Regulation "GAS5 lncRNA promoted the apoptosis of triple-negative and oestrogen receptor-positive cells but only dual PI3K/mTOR inhibition was able to enhance GAS5 levels in all cell types. Reduced GAS5 expression attenuates apoptosis induction by classical chemotherapeutic agents in breast cancer cells, providing an explanation for the relationship between GAS5 expression and breast cancer patient prognosis." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 24789445 GAS5 cancer Regulation "Pickard et al. showed that GAS5 promotes apoptosis of prostate cells after irradiation with UV, and low GAS5 expression therefore reduces the effectiveness of chemotherapeutic agents." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 24757675 GAS5 kidney cancer Expression Tumour suppressor chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 24373479 GAS5 lymphoma Mutation "Chromosomal translocations affecting the 1q25 locus containing the Gas5 gene have been detected in melanoma, B-cell lymphoma, and prostate and breast cancer." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 18836484 GAS5 lymphoma Mutation The GAS5 (growth arrest-specific transcript 5) gene fuses to BCL6 as a result of t(1;3)(q25;q27) in a patient with B-cell lymphoma. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 18406879 GAS5 melanoma Mutation "Chromosomal translocations affecting the 1q25 locus containing the Gas5 gene have been detected in melanoma, B-cell lymphoma, and prostate and breast cancer." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 18836484 GAS5 prostate cancer Expression Tumour suppressor; putative oncogene host chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 24373479 GAS5 prostate cancer Mutation "Chromosomal translocations affecting the 1q25 locus containing the Gas5 gene have been detected in melanoma, B-cell lymphoma, and prostate and breast cancer." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 18836484 Gas5 systemic lupus erythematosus N/A "The Gas5 transcript has been linked with increased susceptibility to systemic lupus erythaematosus in mouse models, presumably as a result of its effect on the immunosuppressant role of glucocorticoids" chr1 161035166 161038537 + Mouse Gas-5; Mir5117; Snhg2 NR_002840 22817756 GAS5 cancer Regulation "ANRIL, GAS5 and lincRNA-p23 are involved in the escape of growth suppression by regulating tumor suppressor genes (ANRIL) or apoptosis regulators." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 24667321 GAS5 cancer Regulation "Binding to GR as a decoy and blocking transcriptional induction by GR, induces growth arrest and apoptosis." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 22996375 GAS5 cancer Regulation "Our own work suggests that while RoR (Zhang et al., 2013a) may function as an oncogene through suppression of p53 in response to DNA damage, loc285194 (Liu et al., 2013) and GAS5 (Zhang et al., 2013b) may play a tumor suppressive role through the “competitive endogenous RNA?(CeRNA) mechanism (Salmena et al., 2011). " chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 24721780 GDNF-AS1 Alzheimer's disease Expression The findings of novel GDNF and GDNFOS isoforms and differences in tissue expression patterns dysregulated in AD brains may further reveal the role of endogenous GDNF in human brain diseases. chr5 37840028 37875799 + Human GDNFOS NR_103441 22081608 GHET1 gastric cancer Regulation Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability. chr7 148987527 148989429 + Human lncRNA-GHET1 NR_130107 24397586 Gm12839 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 29 downregulated in HF hearts as compared with control hearts. chr4 115582286 115583144 - Mouse Cyp4b1-ps2 ENSMUST00000119563 24205036 Bvht cardiovascular disease Expression "Here, we identified Braveheart (Bvht), a heart-associated lncRNA in mouse. Using multiple embryonic stem cell (ESC) differentiation strategies, we show that Bvht is required for progression of nascent mesoderm toward a cardiac fate. " chr18 61639653 61647485 + Mouse Braveheart; Gm20748 NR_045420 23352431 Gm6644 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 12 downregulated in HF hearts as compared with control hearts. chr1 55444074 55445024 - Mouse N/A ENSMUST00000186507 24205036 GNAS-AS1 pseudohypoparathyroidism type Ib Mutation Deletion of the nespas causes pseudohypoparathyroidism Type Ib. chr20 58818918 58850903 - Human GNAS-AS; GNAS1AS; GNASAS; NCRNA00075; NESP-AS; NESPAS; SANG NR_002785 20444925 H19 adrenocortical carcinoma Epigenetics "This disease has been associated with structural abnormalities at the 11p15 locus, which harbors the IGF2 gene as well as the genes coding for insulin, H19, and p57kip2." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 22019903 H19 atherosclerosis Epigenetics The most pronounced differences of atherosclerotic plaques in DNA methylation levels were registered for a site which is located in CpG-island of imprinted gene H19. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 21954592 H19 Beckwith-Wiedemann syndrome Epigenetics Allelic methylation of H19 and IGF2 in the Beckwith-Wiedemann syndrome. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 7987305 H19 Beckwith-Wiedemann syndrome Epigenetics Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 11813134 H19 Beckwith-Wiedemann syndrome Epigenetics Mosaicism for 11p15 UPD and hypermethylation of the H19 gene in blood cells were associated with an increased risk of tumour. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 11436121 H19 Beckwith-Wiedemann syndrome Locus The H19 locus acts in vivo as a tumor suppressor. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 18719115 H19 Beckwith-Wiedemann syndrome Mutation Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 15314640 H19 hydatidiform mole Epigenetics H19 is abnormally methylated on the maternal alleles in BiCHMs. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 12783848 H19 bladder cancer Expression Prognostic marker low-risk marker Oncogene targeted therapy agent chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24373479 H19 bladder cancer Regulation "Control of imprinting breast, cervix, oesophagus prostate, endometrial, colon" chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24499465 H19 bladder cancer Expression The imprinted H19 gene is a marker of early recurrence in human bladder carcinoma. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 11193051 H19 bladder cancer Mutation A significantly decreased risk of bladder cancer was found for the rs2839698 TC genotype but not for CC homozygotes.The rs2839698 TC genotype was especially associated with a reduced risk of developing non-muscle-invasive disease. Borderline significantly chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 18262338 H19 bladder cancer Mutation "An SNP polymorphism in the non-protein-encoding H19 gene is associated with a decreased risk of developing non-muscle-invasive bladder cancer. A significantly decreased risk of bladder cancer was found for the rs2839698 TC genotype, but not for CC homozygotes." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 18262338 H19 bladder cancer N/A Bladder tumors may be successfully treated by intravesical instillation of the double promoter vector H19-DTA-P4-DTA. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 21162716 H19 bladder cancer N/A The H19 non-coding RNA is essential for human tumor growth. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 17786216 H19 bladder cancer Expression Theseguilty by association studies have found numerous bladder-cancer associated lncRNAs chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24006935 H19 bladder cancer Regulation Control of imprinting. Containing miRNA miR-675. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 22996375 H19 bladder cancer Regulation Upregulated H19 contributes to bladder cancer cell proliferation by regulating ID2 expression. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 23354591 H19 bladder cancer Regulation Upregulated H19 contributes to bladder cancer cell proliferation by regulating ID2 expression. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 23399020 H19 breast cancer Expression "Down-regulation of H19 significantly decreases breast and lung cancer cell clonogenicity and anchorage-independent growth. In addition, c-Myc and H19 expression shows strong association in primary breast and lung carcinomas." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 16707459 H19 breast cancer Expression H19 RNA and insulin-like growth factor II mRNA were up-regulated significantly in non-neoplastic WAP-CRD-BP mammary tissue. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 14729626 H19 breast cancer Expression Overexpression of an ectopic H19 gene enhances the tumorigenic properties of breast cancer cells. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 12419837 H19 breast cancer Expression the transcript is stabilized in breast cancer cells and overexpressed in human breast tumors.91H expression is upregulated in breast cancer. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 18794369 H19 breast cancer Mutation Different SNPs in LSP1 and H19 and in minor genes probably were associated with BC risk. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 21996731 H19 breast cancer Mutation "rs2107425 (C>T) near H19 was significantly associated with shorter metastasis-free survival in uni- and multi-variate analysis , with the more aggressive minor allele displaying a recessive trait." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 21748294 H19 breast cancer Regulation Control of imprinting. Containing miRNA miR-675. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 22996375 H19 cancer Expression "H19 expression was found in the hepatic metastases of 64 of 80 patients. High expression (higher staining grades) of H19 in the metastases was found in 43 of 80 patients. However, H19 expression status in the hepatic metastases did not correlate with either the length of time to development of metastasis or overall survival." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 16189152 H19 cancer Expression The human H19 gene is frequently overexpressed in myometrium and stroma during pathological endometrial proliferative events. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 15618002 H19 cervical cancer Mutation High incidence of loss of heterozygosity and abnormal imprinting of H19 and IGF2 genes in invasive cervical carcinomas. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 8570220 H19 choriocarcinoma Regulation Control of imprinting. Containing miRNA miR-675. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 22996375 H19 chronic myeloproliferative disorders Expression Reduced expression of H19 in bone marrow cells from chronic myeloproliferative disorders. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 12682647 H19 colon cancer Expression "DT-A was preferentially expressed in liver metastases after being transfected with H19 or IGF2-P3 promoter-driven DT-A expression plasmids, causing a very significant inhibition of tumor growth as a result of its cytotoxic effect." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 15521051 H19 colon cancer Locus Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 19926638 H19 colon cancer N/A Regional therapy with DTA-H19 vector suppresses growth of colon adenocarcinoma metastases in the rat liver. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 21874233 H19 colon cancer Regulation Control of imprinting. Containing miRNA miR-675. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 22996375 H19 congenital hyperinsulinism Expression "In agreement with the loss of the maternal chromosome, the level of expression of a maternally expressed tumor suppressor gene, H19, was greatly reduced compared to the level of expression of the paternally expressed growth promoter gene, IGF2." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 11395395 H19 esophageal squamous cell carcinoma Regulation Long non-coding RNA 91H contributes to the occurrence and progression of esophageal squamous cell carcinoma by inhibiting IGF2 expression. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24706416 H19 esophageal squamous cell carcinoma Regulation Control of imprinting. Containing miRNA miR-675. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 22996375 H19 gastric cancer Expression Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24810858 H19 gastric cancer Regulation "Using real-time RT-PCR, flow cytometry, RNA immunoprecipitation and other methods, Yang et al confirmed that H19 expression in gastric cancer accelerated cell proliferation." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24833871 H19 gastric cancer Regulation "c-Myc-induced, long, noncoding H19 affects cell proliferation and predicts a poor prognosis in patients with gastric cancer." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24671855 H19 germ cell tumor Epigenetics IGF2/H19 methylation status in GCTs might reflect preservation of the physiologic imprinting erasure in PGCs rather than a loss of imprinting in a sense that is accepted for somatic tumors. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 16001432 H19 gestational choriocarcinoma Expression Prominent expression of H19 was found in placental site trophoblastic tumor and gestational choriocarcinoma. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 8188082 H19 gestational trophoblastic diseases Expression "LOI, deregulation of IGF2 promoters, and the altered expression levels of IGF2 and H19 genes might be associated with the progression of GTD." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 12648595 H19 glioblastoma Expression "Another study performed in CD133+ and CD133- glioblastoma derived primary cell lines revealed levels of H19 expression that were relatively high and low, respectively." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 20380817 H19 glioma Regulation Epigenetic deregulation of lncRNAs genes is associated with disease chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 23791884 H19 glioma Regulation Long non-coding RNA H19 promotes glioma cell invasion by deriving miR-675. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24466011 H19 growth restriction Epigenetics A loss of methylation at H19. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 20104244 H19 malignant hematopoiesis Expression Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 15645136 H19 hepatocellular carcinoma Expression Dysregulation and functional roles of lncRNAs in HCC chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24183851 H19 hepatocellular carcinoma Expression We found that imbalances in levels of IGF2 and H19 transcripts were correlated with advanced tumor stage and poor outcome in HCC patients. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 15736456 H19 hepatocellular carcinoma N/A The H19 non-coding RNA is essential for human tumor growth. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 17786216 H19 hepatocellular carcinoma Expression Overexpression of H19 was found in hepatocellular carcinoma. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24757675 H19 hepatocellular carcinoma Regulation Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 23222811 H19 hyperhomocysteinemia Epigenetics The effect of hyperhomocysteinemia on H19 DMD methylation was tissue-specific. hyperhomocysteinemia produces tissue-specific changes in H19 DMD methylation and increased vascular expression of H19 in adult mice. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 15899898 H19 infertility Expression H19 expression was lower in the infertility group as compared to the control group. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 20042264 H19 kidney cancer Regulation Tumour suppressor; tumour suppressor host chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24373479 H19 liver cancer Epigenetics H19 ICR showed loss-of-imprinting in two steps and allelic histone marker signature during tumorigenesis showed similarity with ES cells. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 21163252 H19 liver cancer Regulation "Control of imprinting breast, cervix, oesophagus prostate, endometrial, colon" chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24499465 H19 liver cancer Regulation Control of imprinting. Containing miRNA miR-675. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 22996375 H19 lung cancer Expression "Down-regulation of H19 significantly decreases breast and lung cancer cell clonogenicity and anchorage-independent growth. In addition, c-Myc and H19 expression shows strong association in primary breast and lung carcinomas." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 16707459 H19 lung cancer Regulation "Control of imprinting breast, cervix, oesophagus prostate, endometrial, colon" chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24499465 H19 lung cancer Regulation Control of imprinting. Containing miRNA miR-675. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 22996375 H19 Marek's disease Mutation The mutant CVI/rpp38 was not only reactive with MAb H19 in IFA but also in immunoprecipitation. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 10696440 H19 medulloblastoma Regulation Epigenetic deregulation of lncRNAs genes is associated with disease chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 23791884 H19 medulloblastoma Epigenetics A study of medulloblastomas and medulloblastoma cell lines showed partial loss of imprinting (LOI) and biallelic expression of H19. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 20380817 H19 melanoma Expression "The study of 4 sensitive and 2 resistant cell lines allowed the identification of 4 genes (RCC1, IFI16, hox2 and h19) preferentially transcribed in sensitive ((IFN-alpha therapy) cells and 2 (SHB and PKC-zeta) preferentially expressed in resistant cells." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 11437411 H19 melanoma Mutation "Although the IGF2 and H19 genotypes/haplotypes were not significantly associated with melanoma, two of the most severe cases (very early onset or multiple melanomas) showed to be heterozygous for both genes." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 20483645 H19 melanoma Expression H19 RNA downregulation stimulated melanogenesis in melasma. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 19968822 H19 meningioma Regulation Epigenetic deregulation of lncRNAs genes is associated with disease chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 23791884 H19 meningioma Epigenetics An examination of meningiomas (World Health Organization grades I-III) demonstrated more robustly that the imprinting status of H19 is perturbed with LOI in a significant number of these tumors. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 20380817 H19 Mullerian aplasia Epigenetics Methylation of H19 and its imprinted control region (H19 ICR1) in Mullerian aplasia. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 21458801 H19 myeloproliferative polycythaemia vera Expression Expression of the imprinted tumour-suppressor gene H19 is tightly regulated during normal haematopoiesis and is reduced in haematopoietic precursors of patients with the myeloproliferative disease polycythaemia vera. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 10640993 H19 neural tube defects Epigenetics "The methylation levels of H19 DMR1 in the NTD and control groups are 73.3%?5.9 and 58.3%?1.2, respectively. Hyper-methylation of the H19 DMR1 may be correlated with the occurrence of NTDs." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 22234160 H19 neuroblastoma Regulation Epigenetic deregulation of lncRNAs genes is associated with disease chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 23791884 H19 obesity Epigenetics Insulin-like Growth Factor 2/H19 Methylation at Birth and Risk of Overweight and Obesity in Children. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 22341586 H19 ovarian cancer Expression H19 RNA was detected in 90% of patients with OCAF (Ovarian cancer ascites fluid ) as determined by ISH. Intratumoral injection of DTA-H19 into ectopically developed tumors caused 40% inhibition of tumor growth. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 19656414 H19 pheochromocytoma Mutation "Tumor DNA from the index patient revealed loss of heterozygosity (LOH) at 11q23, causing loss of the wild-type paternal SDHD allele and LOH affecting maternal 11p15, including H19." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 21937622 H19 pituitary adenoma Regulation Epigenetic deregulation of lncRNAs genes is associated with disease chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 23791884 H19 Prader-Willi syndrome Regulation Epigenetic deregulation of lncRNAs genes is associated with disease chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 23791884 H19 pre-eclampsia Mutation "LOI of H19 can be identified in pre-eclamptic placentas and is associated with maternal blood pressures, which implies the involvement of H19 gene LOI in the pathogenesis of pre-eclampsia and its potential relationship with the severity of the disease." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 19570415 H19 prostate cancer Expression Putative susceptibility and diagnostic marker chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24373479 H19 Silver-Russell syndrome Epigenetics The major finding (~44%) is a hypomethylation of the imprinting control region 1 (ICR1) in 11p15.5 affecting the expression of H19 and IGF2. 4-10% of the patients carry a maternal UPD of chromosome 7 (UPD(7)mat). chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 21150838 H19 Silver-Russell syndrome Mutation Epigenetic mutations of the imprinted IGF2-H19 domain in Silver-Russell syndrome chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 19066168 H19 trophoblastic tumor Expression Prominent expression of H19 was found in placental site trophoblastic tumor and gestational choriocarcinoma. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 8188082 H19 cancer Epigenetics "In recent years, we have extensively investigated the expression of the H19 gene in a number of human cancers and explored the role of H19 RNA in tumor development." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 23429271 H19 cancer Regulation Oncofetal H19 RNA promotes tumor metastasis. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24703882 H19 cancer Expression "H19, a lncRNA with oncogenic properties, is upregulated in a wide range of tumours. " chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 23660942 H19 Beckwith-Wiedemann syndrome Epigenetics Genetic analyses of the patient's blood showed hypermethylation at the H19 locus on chromosome 11p. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 21058226 H19 Wilms' tumor Epigenetics 37% of patients with Wilms' tumor were H19 epimutations. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 22470196 H19 Wilms' tumor Epigenetics Gain of methylation at the H19 DMR is an early event in Wilms' tumorigenesis that is independent of chromosomal losses. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 16179496 HAR1A Alzheimer's disease N/A Schizophrenia spectrum disorders and AD have also been linked with the rheelin (RELN) gene and its antisense transcript HAR1 chr20 63101292 63104385 + Human HAR1F; LINC00064; NCRNA00064 NR_003244 22817756 HAR1A Huntington's disease Expression "HAR1, a deeply conserved genomic region consisting of a cis-antisense pair of structured lncRNAs (HAR1F and HAR1R) (2, 23) located ~80 kb from the neural microRNA, miR-124-3. HAR1 levels are significantly lower in the striatum of HD patients." chr20 63101292 63104385 + Human HAR1F; LINC00064; NCRNA00064 NR_003244 20179156 HAR1A Huntington's disease Regulation "HAR1 has also been implicated in HD, where the transcriptional repressor RE-1-silencing transcription factor (REST) enters pathologically into the nucleus, leading to the repression of several important neuronal genes." chr20 63101292 63104385 + Human HAR1F; LINC00064; NCRNA00064 NR_003244 23562612 HAR1A schizophrenia N/A Schizophrenia spectrum disorders and AD have also been linked with the rheelin (RELN) gene and its antisense transcript HAR1 chr20 63101292 63104385 + Human HAR1F; LINC00064; NCRNA00064 NR_003244 22817756 HAR1B Alzheimer's disease N/A Schizophrenia spectrum disorders and AD have also been linked with the rheelin (RELN) gene and its antisense transcript HAR1 chr20 63095493 63102319 - Human HAR1R; LINC00065; NCRNA00065 NR_003245 22817756 HAR1B Huntington's disease Expression "HAR1, a deeply conserved genomic region consisting of a cis-antisense pair of structured lncRNAs (HAR1F and HAR1R) (2, 23) located ~80 kb from the neural microRNA, miR-124-3. HAR1 levels are significantly lower in the striatum of HD patients." chr20 63095493 63102319 - Human HAR1R; LINC00065; NCRNA00065 NR_003245 20179156 HAR1B Huntington's disease Regulation "HAR1 has also been implicated in HD, where the transcriptional repressor RE-1-silencing transcription factor (REST) enters pathologically into the nucleus, leading to the repression of several important neuronal genes." chr20 63095493 63102319 - Human HAR1R; LINC00065; NCRNA00065 NR_003245 23562612 HAR1B schizophrenia N/A Schizophrenia spectrum disorders and AD have also been linked with the rheelin (RELN) gene and its antisense transcript HAR1 chr20 63095493 63102319 - Human HAR1R; LINC00065; NCRNA00065 NR_003245 22817756 HCP5 AIDS Expression "A total of 245 HIV patients were included in the study. A good correlation between HLA-B*5701 and HCP5 was observed (negative and positive predictive values of 100% and 93%, respectively)." chr6 31463180 31465809 + Human 6S2650E; D6S2650E; P5-1 NR_040662 20534626 HCP5 AIDS Mutation "A polymorphism (rs2395029, G824T) in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro." chr6 31463180 31465809 + Human 6S2650E; D6S2650E; P5-1 NR_040662 19935381 HCP5 AIDS Mutation HCP5 genotyping could serve as a simple screening tool for ABC-HSR. chr6 31463180 31465809 + Human 6S2650E; D6S2650E; P5-1 NR_040662 18684101 HEIH hepatocellular carcinoma Expression "Dr. Yang and his colleagues found that one lncRNA, named lncRNA-HEIH, was overexpressed in HCC tissue compared with normal liver tissues using microarray." chr5 180829954 180831618 - Human HCCAT2; LINC-HEIH; LINC00848; lncRNA-HEIH NR_045680 24757675 HIF1A-AS1 kidney cancer Expression The antitumor DNA topoisomerase I (Top1) inhibitor camptothecin (CPT) increases the cellular levels of two antisense lncRNAs at the 5' (5'aHIF-1 alpha) and 3' (3'aHIF-1 alpha) ends of the human HIF1A-AS1 gene. chr14 61681041 61695823 - Human 5'aHIF-1A; 5'aHIF1alpha NR_047116 21897117 HIF1A-AS1 kidney cancer Expression Diagnostic and discriminative marker chr14 61681041 61695823 - Human 5'aHIF-1A; 5'aHIF1alpha NR_047116 24373479 HIF1A-AS1 kidney cancer Expression overexpressed in human renal cancer and during hypoxia. chr14 61681041 61695823 - Human 5'aHIF-1A; 5'aHIF1alpha NR_047116 9923855 HIF1A-AS2 kidney cancer Expression Diagnostic and discriminative marker chr14 61747039 61749089 - Human 3'aHIF-1A; aHIF NR_045406 24373479 LINC01370 type 2 diabetes mellitus Regulation "Depletion of HI-LNC25, a ?cell-specific lncRNA, downregulated GLIS3 mRNA, thus exemplifying a gene regulatory function of islet lncRNAs. Finally, selected islet lncRNAs were dysregulated in type 2 diabetes or mapped to genetic loci underlying diabetes susceptibility." chr20 40004461 40008529 + Human HI-LNC25; HILNC25 NR_109936 23040067 HLA-AS1 AIDS Mutation "HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles." N/A N/A N/A N/A Human N/A N/A 18982067 HLA-AS1 liver injury Mutation HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. N/A N/A N/A N/A Human N/A N/A 19483685 HLA-AS1 multiple sclerosis Mutation "We identified significant effects on MS susceptibility of HLA-A*2 , and two coding polymorphisms in the MOG gene after full conditioning on HLA-DRB1." N/A N/A N/A N/A Human N/A N/A 17971048 HLA-AS1 psoriasis Mutation HLA-Cw*0602 associates more strongly to psoriasis in the Swedish population than variants of the novel 6p21.3 gene PSORS1C3. N/A N/A N/A N/A Human N/A N/A 15848982 HNF1A-AS1 adenocarcinoma Regulation Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells. chr12 120969838 120972292 - Human C12orf27; NCRNA00262 NR_024345 24000294 HNF1A-AS1 esophageal adenocarcinoma Regulation Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells. chr12 120969838 120972292 - Human C12orf27; NCRNA00262 NR_024345 24000294 HOTAIR B-cell neoplasms Expression "HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24583225 HOTAIR breast cancer Regulation Epigenetically silences gene expression via LSD1/CoREST & PRC2; metastasis chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24499465 HOTAIR breast cancer Expression A subsequent study revealed that HOTAIR is overexpressed in approximately one quarter of human breast cancers. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 20930520 HOTAIR breast cancer Expression Elevated expression of HOTAIR is observed in primary and metastatic breast cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 21925379 HOTAIR breast cancer Expression HOTAIR expression level in primary tumors is a powerful predictor of eventual metastasis and death. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 20393566 HOTAIR breast cancer Expression "HOTAIR is increased in expression in primary breast tumours and metastases, and HOTAIR expression level in primary tumours is a powerful predictor of eventual metastasis and death." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 20393566 HOTAIR breast cancer Expression HOTAIR showed positive association with 'hang Serum Response'. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 19182780 HOTAIR breast cancer Expression "Recently, augmented levels of HOTAIR in primary breast tumors were shown to correlate with breast cancer invasiveness and metastasis." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 20393566 HOTAIR breast cancer Expression The lncRNA HOTAIR is a strong predictor of metastasis in breast tumors and its over-expression in various breast carcinoma cell lines promotes invasion. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 21903344 HOTAIR breast cancer Expression "For example, HOTAIR is remarkably overexpressed in breast tumors and the expression of HOTAIR in primary breast tumors is a strong prognosis marker of patient outcomes such as metastasis and patient survival " chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24721780 HOTAIR breast cancer Expression "HOTAIR was proposed as a diagnostic marker in breast and colorectal cancer. Its depletion resulted in reduced invasiveness, and its expression level correlated with differentially regulated genes of the PRC2 complex." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24531795 HOTAIR breast cancer Expression "In approximately one-quarter of human breast cancers, HOTAIR is highly induced, while its elevated levels are also predictive of metastasis and disease progression in other cancers, such as colon, colorectal, gastrointestinal, pancreatic and liver cancer." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24667321 HOTAIR breast cancer Expression "Overexpression of the HOTAIR transcript, a cis-lncRNA associated with the HOXD gene cluster, has been associated with hepatocellular carcinoma [32], colorectal cancer [33] and breast cancer [13] by deregulation of HOXD cluster genes" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 22817756 HOTAIR breast cancer Expression "Recent studies have linked their mis-expression to diverse cancers (ANRIL: prostate cancer, XIST: female cancers, HOTAIR: breast cancer, KCNQ1OT3: colorectal cancer)." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23660942 HOTAIR breast cancer Expression "The wellstudied lincRNA, HOTAIR, is highly expressed in breast cancer metastases, and its overexpression in various breast carcinoma cell lines promotes invasion" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 22535282 HOTAIR breast cancer Regulation Gene silencing by interacting with PRC2 and LSD1/CoREST complexes. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 22996375 HOTAIR breast cancer Regulation "On a more mechanistic level, recent studies have revealed the contribution of lncRNAs as proto-oncogenes, e.g. GAGE6, as tumor suppressor genes, e.g. 鈥榩15 antisense RNA and lincP21' (36,91), as drivers of metastatic transformation, e.g. HOTAIR in breast cancer, and as regulators of alternative splicing, e.g. MALAT1" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 22492512 HOTAIR breast cancer Regulation Gupta et al found that lncRNA HOTAIR overexpression was a strong predictor of breast tumor metastasis. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24829860 HOTAIR breast cancer Regulation Gene silencing by interacting with PRC2 and LSD1/CoREST complexes. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 22996375 HOTAIR cancer Epigenetics Epigenetically silences gene expression at many loci by recruitment of LSD1/CoREST/REST and PRC2 repressive chromatin modifying complexes. Oncogene: promotes tumour metastasis. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 21256239 HOTAIR cancer Epigenetics Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 20393566 HOTAIR cancer Expression HOTAIR is causally involved in tumor progression. It is significantly overexpressed in metastatic breast cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 22045689 HOTAIR cancer Expression Overexpression of HOTAIR was found in breast and colon cancers and was associated with metastasis and poor prognosis. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24757675 HOTAIR cancer Expression Long Non-coding RNA HOTAIR Is Targeted and Regulated by miR-141 in Human Cancer Cells. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24616104 HOTAIR cancer Regulation Forced expression of HOTAIR in epithelial cancer cells altered the localization of PRC2 on chromatin. Genome-wide studies revealed PRC2 localization more resembling occupancy in embryonic fibroblasts. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24829860 HOTAIR cancer Expression HOTAIR overexpression has been linked to increased invasiveness and poorer outcomes in several human cancers. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23473599 HOTAIR cancer Expression "HOTAIR overexpression is associated with poor prognosis in breast (Gupta et al. 2010), liver (Z. Yang et al. 2011), colorectal (Kogo et al. 2011), gastrointestinal (Niinuma et al. 2012), and pancreatic (Kim et al. 2012) cancers and is proposed to increase tumor invasiveness and metastasis (Gupta et al. 2010)." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23463798 HOTAIR cancer Expression It is overexpressed in various carcinomas including breast cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23463798 HOTAIR cervical cancer Expression Overexpression of long noncoding RNA HOTAIR predicts a poor prognosis in patients with cervical cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24748337 HOTAIR colon cancer Expression "In approximately one-quarter of human breast cancers, HOTAIR is highly induced, while its elevated levels are also predictive of metastasis and disease progression in other cancers, such as colon, colorectal, gastrointestinal, pancreatic and liver cancer." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24667321 HOTAIR colorectal cancer Expression "HOTAIR was proposed as a diagnostic marker in breast and colorectal cancer. Its depletion resulted in reduced invasiveness, and its expression level correlated with differentially regulated genes of the PRC2 complex." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24531795 HOTAIR colorectal cancer Epigenetics Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers.patients with high HOTAIR expression had a relatively poorer prognosis. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 21862635 HOTAIR colorectal cancer Expression "In approximately one-quarter of human breast cancers, HOTAIR is highly induced, while its elevated levels are also predictive of metastasis and disease progression in other cancers, such as colon, colorectal, gastrointestinal, pancreatic and liver cancer." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24667321 HOTAIR colorectal cancer Expression "Overexpression of the HOTAIR transcript, a cis-lncRNA associated with the HOXD gene cluster, has been associated with hepatocellular carcinoma [32], colorectal cancer [33] and breast cancer [13] by deregulation of HOXD cluster genes" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 22817756 HOTAIR colorectal cancer Regulation "HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24583926 HOTAIR endometrial cancer Regulation Lentivirus-Mediated RNA Interference Targeting the Long Noncoding RNA HOTAIR Inhibits Proliferation and Invasion of Endometrial Carcinoma Cells In Vitro and In Vivo. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24758900 HOTAIR endometrial cancer Expression The long non-coding RNA HOTAIR is upregulated in endometrial carcinoma and correlates with poor prognosis. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24285342 HOTAIR ovarian cancer Expression Overexpression of long non-coding RNA HOTAIR predicts poor patient prognosis and promotes tumor metastasis in epithelial ovarian cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24662839 HOTAIR esophageal squamous cell carcinoma Expression "Similarly, patients with high HOTAIR expression suffered a significantly poorer prognosis than those with low expression." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24817925 HOTAIR esophageal squamous cell carcinoma Expression "The result showed that the expression levels of HOTAIR were upregulated in samples from patients with higher tumor burdens, which were defined as those with larger tumors, advanced clinical staging, increased lymph node tumor burdens and the presence of distant metastases." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24817925 HOTAIR esophageal squamous cell carcinoma Expression "Expression of HOTAIR lncRNA is increased in various cancers, and it is also significantly increased in our analysis of ESCC." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24222893 HOTAIR esophageal squamous cell carcinoma Expression "Upregulation of HOTAIR is associated with metastasis of gastric cancer, lung cancer, and esophageal squamous cell carcinoma." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24757675 HOTAIR gastric cancer Expression "Upregulation of HOTAIR is associated with metastasis of gastric cancer, lung cancer, and esophageal squamous cell carcinoma." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24757675 HOTAIR gastric cancer Regulation Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24775712 HOTAIR gastrointestinal cancer Expression "In approximately one-quarter of human breast cancers, HOTAIR is highly induced, while its elevated levels are also predictive of metastasis and disease progression in other cancers, such as colon, colorectal, gastrointestinal, pancreatic and liver cancer." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24667321 HOTAIR gastrointestinal cancer Expression Overexpression of HOTAIR was also strongly associated with high-risk grade and metastasis among GIST specimens. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 22258453 HOTAIR gastrointestinal cancer Expression Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 22258453 HOTAIR hepatocellular carcinoma Expression Dysregulation and functional roles of lncRNAs in HCC chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24183851 HOTAIR hepatocellular carcinoma Expression Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 21327457 HOTAIR hepatocellular carcinoma Expression The HOTAIR gene was significantly overexpressed in HCC tissues compared with adjacent non-tumour tissues. Patients with high HOTAIR gene expression in their tumours had an increased risk of recurrence after hepatectomy. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 22289527 HOTAIR hepatocellular carcinoma Expression The high expression level of HOTAIR in HCC could be a candidate biomarker for predicting tumor recurrence in HCC patients who have undergone liver transplant therapy and might be a potential therapeutic target. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 21327457 HOTAIR hepatocellular carcinoma Expression Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23292722 HOTAIR hepatocellular carcinoma Expression "Overexpression of the HOTAIR transcript, a cis-lncRNA associated with the HOXD gene cluster, has been associated with hepatocellular carcinoma [32], colorectal cancer [33] and breast cancer [13] by deregulation of HOXD cluster genes" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 22817756 HOTAIR hepatocellular carcinoma Regulation Long non-coding RNA HOTAIR promotes cell migration and invasion via down-regulation of RNA binding motif protein 38 in hepatocellular carcinoma cells. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24663081 HOTAIR laryngeal squamous cell carcinoma Expression "Inspired observed that HOTAIR was higher expressed in primary LSCC than in adjacent noncancerous tissues. It is noteworthy that over-expression of HOTAIR was related to poor differentiation, lymph node metastasis, or advanced clinical stages of LSCC. The results suggested that HOTAIR promotes the malignant progression of LSCC." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24817925 HOTAIR liver cancer Expression "In approximately one-quarter of human breast cancers, HOTAIR is highly induced, while its elevated levels are also predictive of metastasis and disease progression in other cancers, such as colon, colorectal, gastrointestinal, pancreatic and liver cancer." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24667321 HOTAIR lung adenocarcinoma Regulation "In this study, the lncRNA HOTAIR was upregualted in lung adenocarcinoma cells grown in 3-D cell culture supplemented with collagen." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24829860 HOTAIR lung cancer Expression "Upregulation of HOTAIR is associated with metastasis of gastric cancer, lung cancer, and esophageal squamous cell carcinoma" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24757675 HOTAIR nasopharyngeal carcinoma Expression "The result showed that, the expression levels of HOTAIR wereup-regulated in NPC tissues than in non-cancerous tissues. Further study demonstrated that HOTAIR was up-regulated in NPC cell lines with high invasive potential and the capacity for migration, invasion and proliferation was suppressed after knocking down HOTAIR expression." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24817925 HOTAIR non-small cell lung cancer Expression Long non-coding RNA HOTAIR is a powerful predictor of metastasis and poor prognosis and is associated with epithelial-mesenchymal transition in colon cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24840737 HOTAIR esophageal squamous cell carcinoma Regulation "Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24022190 HOTAIR oral squamous cell carcinoma Expression "Subsequently, they confirmed that the expression levels of HOTAIR, NEAT-1 and UCA1 in metastasized samples was prominent higher than the non-metastatic samples." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24817925 HOTAIR pancreatic cancer Expression "In approximately one-quarter of human breast cancers, HOTAIR is highly induced, while its elevated levels are also predictive of metastasis and disease progression in other cancers, such as colon, colorectal, gastrointestinal, pancreatic and liver cancer." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24667321 HOTAIR rheumatoid arthritis Regulation PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24722995 HOTAIR small cell lung cancer Regulation "Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24591352 HOTAIR cancer Expression "Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24469926 HOTAIR cancer Regulation "HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24583926 HOTTIP hepatocellular carcinoma Expression "Currently, upregulated HOTTIP and HOXA13 expressions were associated with the prognosis and progression of the hepatocellular carcinoma (HCC). " chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 24531795 HOTTIP hepatocellular carcinoma Expression Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 24114970 HOTTIP hepatocellular carcinoma Expression lncRNA HOTTIP / HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 24114970 HTT-AS Huntington's disease Expression "Levels of HTTAS_v1 are reduced in human HD frontal cortex. In cell systems, overexpression of HTTAS_v1 specifically reduces endogenous HTT transcript levels, while siRNA knockdown of HTTAS_v1 increases HTT transcript levels." chr4 3063246 3074514 - Human HTT-AS1; HTTAS NR_045414 21672921 HTTAS_v1 Huntington's disease Regulation Long ncRNA HTTAS_v1 is regulating the expression of Hungtiontonin (HTT) and is potentially involved in the development of HD. N/A N/A N/A N/A Human N/A N/A 24624135 HULC hepatic colorectal metastasis Expression "HULC expression is not confined to HCC, but also to those colorectal carcinomas that metastasize to the liver." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 19445043 HULC hepatocellular carcinoma Expression Dysregulation and functional roles of lncRNAs in HCC chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 24183851 HULC hepatocellular carcinoma Regulation "Here we focus on two best-characterized lncRNAs-HULC and LALR, which can impact proliferation through targeting various key regulators in different pathways." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 24296588 HULC hepatocellular carcinoma Regulation "A lncRNA, highly upregulated in liver cancer (HULC), was found to contribute to tumorigenesis of HCC." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 24757675 HULC hepatocellular carcinoma Expression "A similar genome-wide differential expression screen in hepatocellular carcinoma (HCC) has uncovered another cancer-associated lncRNA, Highly Upregulated in Liver Cancer, or HULC." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 20951849 HULC hepatocellular carcinoma Expression Highly up-regulated in liver cancer. chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 17241883 HULC hepatocellular carcinoma Expression "Long non-coding RNA (lncRNA), highly up-regulated in liver cancer (HULC) plays an important role in tumorigenesis. Depletion of HULC resulted in a significant deregulation of several genes involved in liver cancer. Although up-regulation of HULC expression." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 20423907 HULC hepatocellular carcinoma Expression The lncRNA HULC is one of the most upregulated of all genes in hepatocellular carcinoma. chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 21802130 HULC hepatocellular carcinoma Regulation "Moreover, HULC correlated with upregulated hepatitis B virus X protein (HBx) that importantly contributes to HCC and that was able to promote HULC expression. The HULC-mediated downregulation of the tumor suppressor p18 supported the HCC proliferation." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 24531795 HULC liver cancer N/A "PCGEM1, PCA3 (prostate cancer antigen 3, known also as DD3, differential display code 3) and PCNCR1 (prostate cancer ncRNA 4) are involved in prostate cancer, while HULC (highly up-regulated in liver cancer) is involved with liver cancer." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 24667321 HULC liver cancer Expression "The highly upregulated lncRNA HULC in liver cancer was found in the blood of HCC patients, promising a potential biomarker. " chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 24531795 HYMAI transient neonatal diabetes mellitus Expression "In TNDM fibroblasts, the monoallelic expression of both ZAC and HYMAI is relaxed, providing strong supportive evidence that the presence of two unmethylated alleles of this locus is indeed associated with the inappropriate gene expression of neighbouring genes." chr6 144004916 144008730 - Human NCRNA00020 NR_002768 11935319 IFNG-AS1 multiple sclerosis N/A Tmevpg1 (IFNG-AS1) is another lncRNA that may be involved in MS. chr12 67989445 68021327 + Human GS1-410F4.2; NEST; Tmevpg1 NR_104124 12719555 IGF2-AS hepatocellular carcinoma N/A IGF-IR and IGF-IIR antisense genes could significantly restrain the malignant behavior of human hepatoma cells and might be useful in investigating a potential route for hepatocellular carcinoma gene therapy. chr11 2140512 2148666 + Human IGF2-AS1; IGF2AS; PEG8 NR_133657 12603530 IGF2-AS prostate cancer Mutation Association identified by GWAS. chr11 2140512 2148666 + Human IGF2-AS1; IGF2AS; PEG8 NR_133657 19767753 IGF2-AS type 1 diabetes mellitus Mutation Association identified by GWAS. chr11 2140512 2148666 + Human IGF2-AS1; IGF2AS; PEG8 NR_133657 17554260 IGF2-AS Wilms' tumor Expression Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor. chr11 2140512 2148666 + Human IGF2-AS1; IGF2AS; PEG8 NR_133657 12702581 IGF2-AS Wilms' tumor Expression "PEG8/IGF2AS and IGF2 were found to be overexpressed in Wilms' tumor samples, at levels over ten and a hundred times higher than that in normal kidney tissues neighboring the tumors, respectively." chr11 2140512 2148666 + Human IGF2-AS1; IGF2AS; PEG8 NR_133657 10731720 IPW Prader-Willi syndrome Expression "The Prader-Willi syndrome (PWS) is caused by genomic alterations that inactivate imprinted, paternally expressed genes in human chromosome region 15q11-q13. IPW, a paternally expressed gene cloned from this region, is not expressed in individuals with PWS." chr15 25116545 25122476 + Human NCRNA00002 NR_023915 9063754 IPW Prader-Willi syndrome Locus IPW (Imprinted gene in the Prader-Willi syndrome region) was isolated using the direct selection method and yeast artificial chromosomes localized to the deletion region. the mRNA product of IPW may play a role in the imprinting process. chr15 25116545 25122476 + Human NCRNA00002 NR_023915 7849716 IPW Prader-Willi syndrome Mutation Genetic variation in lncRNA genes causes disease and influences susceptibility chr15 25116545 25122476 + Human NCRNA00002 NR_023915 23791884 IPW Prader-Willi syndrome Expression "Subsequently, we determined that IPW, along noncoding RNAin the critical region of the PWS locus, is a regulator of the DLK1-DIO3 region, as its overexpression in PWS and parthenogenetic iPSCs resulted in downregulation of MEGs in this locus." chr15 25116545 25122476 + Human NCRNA00002 NR_023915 24816254 Kcna2 antisense RNA neuropathic pain Regulation A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. N/A N/A N/A N/A Human N/A N/A 23792947 KCNQ1DN aging Epigenetics Continuously hypermethylated upon aging. chr11 2870033 2872105 + Human BWRT; HSA404617 NR_024627 22067257 KCNQ1DN Wilms' tumor Expression "A novel imprinted gene, KCNQ1DN, within the WT2 critical region of human chromosome 11p15.5 and its reduced expression in Wilms' tumors." chr11 2870033 2872105 + Human BWRT; HSA404617 NR_024627 11056398 KCNQ1OT1 Beckwith-Wiedemann syndrome Epigenetics "In Beckwith-Wiedemann syndrome (BWS), approximately 50% of patients show loss of DNA methylation accompanied by loss of histone H3 Lys9 dimethylation on maternal KCNQ1OT-DMR, namely an imprinting disruption, leading to diminished expression of CDKN1C." chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 16575194 KCNQ1OT1 Beckwith-Wiedemann syndrome Epigenetics The 5'end of the KCNQ1OT1 gene is hypomethylated in the Beckwith-Wiedemann syndrome. chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 12136243 KCNQ1OT1 Beckwith-Wiedemann syndrome Locus "In the human and mouse BWS imprinting regions, two major elements for regulation of imprinted gene expression have been identified athe imprinting centers IC1 and IC2.IC2 appears to be the promoter of the paternally expressed probably noncoding transcript." chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 15590939 KCNQ1OT1 Beckwith-Wiedemann syndrome Locus KvDMR1 and/or its associated antisense RNA (KvLQT1-AS) represents an additional imprinting control element or center in the human 11p15.5 and mouse distal 7 imprinted domains. chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 10393948 KCNQ1OT1 Beckwith-Wiedemann syndrome Locus "The LIT1 CpG island can act as a negative regulator in cis for coordinate imprinting at the centromeric domain, thereby suggesting a role for the LIT1 locus in a BWS pathway leading to functional inactivation of p57(KIP2)." chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 10958646 KCNQ1OT1 Beckwith-Wiedemann syndrome N/A In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene. chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 12746837 KCNQ1OT1 Beckwith-Wiedemann syndrome N/A LIT1 (KCNQ1OT1) may play a role in Beckwith-Wiedemann syndrome. chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 15888726 KCNQ1OT1 Beckwith-Wiedemann syndrome Regulation Epigenetic deregulation of lncRNAs genes is associated with disease chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 23791884 KCNQ1OT1 colorectal cancer Epigenetics epigenetic disruption chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 16965397 KCNQ1OT1 colorectal cancer Expression "Recent studies have linked their mis-expression to diverse cancers (ANRIL: prostate cancer, XIST: female cancers, HOTAIR: breast cancer, KCNQ1OT4: colorectal cancer)." chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 23660942 KCNQ1OT1 hepatocellular carcinoma Mutation A novel tetranucleotide repeat polymorphism within KCNQ1OT1 confers risk for hepatocellular carcinoma. chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 23984860 KCNQ1OT1 kidney cancer Regulation Oncogene chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 24373479 KRAS1P cancer Regulation "Similarly, KRAS and KRAS1P transcript levels were found to be positively correlated, corroborating that pseudogene functions mirror the role of their cognate genes as explained by the miRNA decoy mechanism." N/A N/A N/A N/A Human N/A N/A 24757675 LINC00850 Duchenne muscular dystrophy Mutation Molecular characterization of an X(p21.2;q28) chromosomal inversion in a Duchenne muscular dystrophy patient with mental retardation reveals a novel long non-coding gene on Xq28 chrX 149825708 149879799 + Human KUCG1 NR_109813 23223008 LINC00850 Duchenne muscular dystrophy Expression "KUCG1 is a 648-bp nuclear lncRNA expressed in a tissue specific manner. Since it is normally expressed in the brain, its deregulation could contribute to the neurological impairment of the patient as already reported for other pathologies." chrX 149825708 149879799 + Human KUCG1 NR_109813 24685002 LALR hepatocellular carcinoma Regulation "Here we focus on two best-characterized lncRNAs-HULC and LALR, which can impact proliferation through targeting various key regulators in different pathways." N/A N/A N/A N/A Human N/A N/A 24296588 LINC00032 melanoma Mutation "An analysis of genome-wide DNA copy number alterations in melanoma tumors revealed the loss of the C9orf14 locus, located proximal to CDKN2A, in approximately one-fourth of tumors." chr9 27245684 27282793 - Human C9orf14; NCRNA00032 NR_026679 17099875 PICSAR narcolepsy Mutation Association identified by GWAS. chr21 44999208 45004727 - Human C21orf113; LINC00162; NCRNA00162; NLC1-C; NLC1C; PRED74 NR_024089 16826516 LINC00271 schizophrenia Mutation This gene is associated with susceptibility to schizophrenia. chr6 135497801 135690838 + Human C6orf217; NCRNA00271 NR_026805 16773125 LINC00271 type 2 diabetes mellitus Mutation Association identified by GWAS. chr6 135497801 135690838 + Human C6orf217; NCRNA00271 NR_026805 17668382 LINC00299 intellectual and developmental disability Mutation Genetic variation in lncRNA genes causes disease and influences susceptibility chr2 8007771 8328419 - Human C2orf46; NCRNA00299 NR_034135 23791884 LINC00312 nasopharyngeal carcinoma Expression NAG-7 is a novel gene downregulated in human nasopharyngeal carcinoma. chr3 8571782 8574668 + Human ERR-10; ERR10; LMCD1DN; LOH3CR2A; NAG-7; NAG7; NCRNA00312 NR_024065 11780420 LINC00312 nasopharyngeal carcinoma Expression NAG7 (LINC00312) gene re-expression could inhibit overproliferation of NPC cell by delaying the progression of G1 into S in cell cycle and inducing cell apoptosis. chr3 8571782 8574668 + Human ERR-10; ERR10; LMCD1DN; LOH3CR2A; NAG-7; NAG7; NCRNA00312 NR_024065 12452030 LINC00312 nasopharyngeal carcinoma Interaction NAG7 (LINC00312) promotes human nasopharyngeal carcinoma invasion through inhibition of estrogen receptor alpha and up-regulation of JNK2/AP-1/MMP1 pathways. chr3 8571782 8574668 + Human ERR-10; ERR10; LMCD1DN; LOH3CR2A; NAG-7; NAG7; NCRNA00312 NR_024065 19591174 LINC00312 nasopharyngeal carcinoma Expression "Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma." chr3 8571782 8574668 + Human ERR-10; ERR10; LMCD1DN; LOH3CR2A; NAG-7; NAG7; NCRNA00312 NR_024065 23529758 LINC00963 prostate cancer Regulation "Linc00963: a novel, long non-coding RNA involved in the transition of prostate cancer from androgen-dependence to androgen-independence." chr9 129488660 129513686 + Human N/A NR_038955 24691949 LINC01262 Parkinson's disease Expression "These included the U1 spliceosomal lncRNA and RP11-462G22.1, each entailing sequence complementarity to numerous microRNAs." chr4 189659606 189661486 + Human TCONS_l2_00021807 NR_121679 24651478 LINCMD1 Duchenne muscular dystrophy Expression "Interestingly, the levels of linc-MD1 are strongly reduced in primary myoblasts of DMD patients and its ectopic expression rescues the myogenic differentiation potential of these cells, restoring the correct expression pattern of MAML1, MEF2C, MYOG and MHC. " chr6 52146814 52151023 - Human LINC-MD1; MIR133BHG NR_131248 24685002 lincRNA-p21 lung cancer Expression "lincRNAp21 is required for the global repression of genes that interfere with p53 function regulating cellular apoptosis. lincRNAp21 can mediate gene repression by physically interacting with the protein hnRNP-K, allowing its localization to promoters of genes to be repressed in a p53-dependent manner, and its overexpression in a lung cancer cell line sensitizes the cells to DNA" N/A N/A N/A N/A Human N/A N/A 22535282 lincRNA-p21 cancer Regulation "Global gene repression in the p53 transcriptional response by binding hnRNP-K, inducing cellular apoptosis." N/A N/A N/A N/A Human N/A N/A 22996375 lincRNA-p21 cancer Regulation "Thus, similar to its activator p53, lincRNA-p21 may play an important role in tumour suppression by operating as a transcriptional repressor." N/A N/A N/A N/A Human N/A N/A 23660942 LIPCAR heart failure Expression "Circulating Long Noncoding RNA, LIPCAR, Predicts Survival in Patients With Heart Failure.The mitochondrial long noncoding RNA uc022bqs.1 (LIPCAR) was downregulated early after myocardial infarction but upregulated during later stages. LIPCAR levels identified patients developing cardiac remodeling and were independently to other risk markers associated with future cardiovascular deaths." N/A N/A N/A N/A Human N/A N/A 24663402 lnc-AL355149.1-1 nasopharyngeal carcinoma Expression "Results. In primary NPC, upregulation of lnc-C22orf32-1, lnc-AL355149.1-1, and lnc-ZNF674-1 was observed. High levels of lnc-C22orf32-1 and lnc-AL355149.1-1 were significantly associated with the male patients" N/A N/A N/A N/A Human N/A N/A 24822202 LINC01315 nasopharyngeal carcinoma Expression "Results. In primary NPC, upregulation of lnc-C22orf32-1, lnc-AL355149.1-1, and lnc-ZNF674-1 was observed. High levels of lnc-C22orf32-1 and lnc-AL355149.1-1 were significantly associated with the male patients" chr22 42364400 42369208 - Human lnc-C22orf32-1 NR_120596 24822202 lncRNA-ATB hepatocellular carcinoma Regulation "Thus, these findings suggest that lncRNA-ATB, a mediator of TGF-β signaling, could predispose HCC patients to metastases and may serve as a potential target for antimetastatic therapies." N/A N/A N/A N/A Human N/A N/A 24768205 LncRNA-LALR1 liver cancer Regulation LncRNA-LALR1 accelerates hepatocyte proliferation during liver regeneration by activating Wnt/β-Catenin signaling N/A N/A N/A N/A Human N/A N/A 23483581 NPTN-IT1 cancer Expression "Aberrant Expression of lncRNA-LET in Tumor Tissue. In this study, we found that the lncRNA Low Expression in Tumor (lncRNA-LET) was generally downregulated in hepatocellular carcinomas, colorectal cancers, and squamous-cell lung carcinomas. " chr15 73566938 73569543 - Human lncRNA-LET NR_103844 23395002 lncRNA-MVIH hepatocellular carcinoma Regulation Dr. Yuan et al. found that lncRNA-MVIH could promote tumor growth and intrahepatic metastasis by contributing to active angiogenesis both in vitro and in vivo through the inhibition of phosphoglycerate kinase 1 (PGK1) secretion N/A N/A N/A N/A Human N/A N/A 24757675 lncRNA-MVIH hepatocellular carcinoma Expression Yuan et al discovered that the lncRNA MVIH (long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma) was overexpressed in hepatocellular carcinoma. N/A N/A N/A N/A Human N/A N/A 24829860 lncRNA-MVIH non-small cell lung cancer Regulation Long non-coding RNA MVIH indicates a poor prognosis for non-small cell lung cancer and promotes cell proliferation and invasion. N/A N/A N/A N/A Human N/A N/A 24793017 lnc-ZNF674-1 nasopharyngeal carcinoma Expression "Results. In primary NPC, upregulation of lnc-C22orf32-1,lnc-AL355149.1-1, and lnc-ZNF674-1 was observed. High levels of lnc-C22orf32-1 and lnc-AL355149.1-1 were significantly associated with the male patients" N/A N/A N/A N/A Human N/A N/A 24822202 LOC102635190 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 11 downregulated in HF hearts as compared with control hearts. N/A N/A N/A N/A Mouse N/A AK139454.1 24205036 LOC389023 psychiatric disease Regulation "Examples of recently discovered chromatin-bound long non-coding RNAs important for neuronal health and function include the brain-derived neurotrophic factor antisense transcript (Bdnf-AS) which regulates expression of the corresponding sense transcript, and LOC389023 which is associated with human-specific histone methylation signatures at the chromosome 2q14.1 neurodevelopmental risk locus by regulating expression of DPP10, an auxillary subunit for voltage-gated K(+) channels." N/A N/A N/A N/A Human N/A N/A 23831425 LOC554202 breast cancer Regulation Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells. N/A N/A N/A N/A Human N/A N/A 24631686 LOC728606 prostate cancer Expression "The most highly up-regulated transcript was LOC728606, a lncRNA now designated PCAT18. PCAT18 is specifically expressed in the prostate compared to 11 other normal tissues (p<0.05) and up-regulated in PCa compared to 15 other neoplasms (p<0.001)." N/A N/A N/A N/A Human N/A N/A 24519926 TUSC7 osteosarcoma Mutation These CNAs (copy number alterations) in osteosarcoma often involve the noncoding RNAs LOC285194 and BC040587. chr3 116709788 116717040 + Human LINC00902; LSAMP-AS1; LSAMP-AS3; LSAMPAS3; NCRNA00295 NR_015391 20048075 LSINCT5 breast cancer Expression LSINCT5 is overexpressed in breast and ovarian cancer cell lines and tumor tissues. chr5 2712591 2715237 - Human N/A NR_145480 21532345 LSINCT5 breast cancer Expression "Ovarian and breast tumours have also been associated with the expression of the LSINCT5 lncRNA; this transcript acts to target several other transcripts, including the antisense RNA NEAT-1 and the PSPC1 gene, which codes for a splicing regulatory factor" chr5 2712591 2715237 - Human N/A NR_145480 22817756 LSINCT5 ovarian cancer Expression LSINCT5 is overexpressed in breast and ovarian cancer cell lines and tumor tissues. chr5 2712591 2715237 - Human N/A NR_145480 21532345 LSINCT5 ovarian cancer Expression "Ovarian and breast tumours have also been associated with the expression of the LSINCT5 lncRNA; this transcript acts to target several other transcripts, including the antisense RNA NEAT-1 and the PSPC1 gene, which codes for a splicing regulatory factor" chr5 2712591 2715237 - Human N/A NR_145480 22817756 MALAT1 B-cell neoplasms Expression "HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24583225 MALAT1 bladder cancer Regulation Oncogene chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24373479 MALAT1 bladder cancer Expression Theseguilty by association studies have found numerous bladder-cancer associated lncRNAs chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24006935 MALAT1 breast cancer Regulation "On a more mechanistic level, recent studies have revealed the contribution of lncRNAs as proto-oncogenes, e.g. GAGE6, as tumor suppressor genes, e.g. 鈥榩15 antisense RNA and lincP21' (36,91), as drivers of metastatic transformation, e.g. HOTAIR in breast cancer, and as regulators of alternative splicing, e.g. MALAT1" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 22492512 MALAT1 breast cancer Regulation Sequesters SR splicing factors to regulate alternative splicing. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 22996375 MALAT1 breast cancer Regulation "invasion & metastasis pancreas, colon, prostate liver, cervix, neuroblastoma osteosarcoma" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24499465 MALAT1 cancer Expression MALAT1 is a highly conserved long ncRNA originally identified as a transcript overexpressed in many cancers. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 20864030 MALAT1 cancer Expression "The expression of the long ncRNA MALAT1 correlates with tumor development, progression or survival in lung, liver and breast cancer." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 20711585 MALAT1 cancer Expression MALAT1 is upregulated in several cancer types and its overexpression has been linked to an increase in cell proliferation and migration in lung and colorectal cancer cells. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 23660942 MALAT1 cancer Regulation "They found that MALAT1 did not alter alternative splicing but rather actively regulated gene expression including a set of metastasis-associated genes. Consequently, MALAT1-deficient cells were impaired in migration and formed fewer tumor nodules in mouse xenograft. Antisense oligonucleotides (ASO) that block MALAT1 prevented metastasis formation after tumor implantation." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24757675 MALAT1 cancer Regulation "MALAT1 (metastasis-associated lung adenocarcinoma transcript 1),another lncRNA associated with various cancers and metastasis (Ji et al. 2003; Lin et al. 2011), is found to affect the transcriptional and post-transcriptional regulation of cytoskeletal and extracellular matrix genes." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 23463798 MALAT1 cervical cancer Interaction "MALAT1 was involved in cervical cancer cell growth, cell cycle progression, and invasion through the regulation of gene expression, such as caspase-3, -8, Bax, Bcl-2, and BclxL." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 20213048 MALAT1 cervical cancer Expression "Overexpressed MALAT1 was found in many solid tumors such as lung cancer, cervical cancer, and HCC." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24757675 MALAT1 colon cancer Regulation Sequesters SR splicing factors to regulate alternative splicing. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 22996375 MALAT1 colorectal cancer N/A The 3' end of MALAT-1 is an important biological motif in the invasion and metastasis of CRC cells. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 21503572 MALAT1 decreased myogenesis Expression The myostatin-induced inhibition of the long noncoding RNA Malat1 is associated with decreased myogenesis. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 23485710 MALAT1 diabetes mellitus Expression "In addition, MALAT1, a conserved lncRNA, was significantly upregulated in an RF/6A cell model of hyperglycemia, in the aqueous humor samples, and in fibrovascular membranes of diabetic patients." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24436191 MALAT1 endometrial cancer Expression MALAT-1 gene is one of the major genes upregulated in ESS. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 16441420 MALAT1 gallbladder cancer Regulation MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24658096 MALAT1 hepatocellular carcinoma Expression Dysregulation and functional roles of lncRNAs in HCC chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24183851 MALAT1 hepatocellular carcinoma Expression "HCC and HPBL have clearly different patterns of gene expression, with genes IGF2, Fibronectin, DLK1, TGFb1, MALAT1 and MIG6 being over-expressed in HPBL versus HCC" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 17006932 MALAT1 hepatocellular carcinoma Expression "HCC and HPBL have clearly different patterns of gene expression, with genes IGF2, Fibronectin, DLK1, TGFb1, MALAT1 and MIG6 being over-expressed in HPBL versus HCC." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 17006932 MALAT1 hepatocellular carcinoma Expression Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 21678027 MALAT1 hepatocellular carcinoma Expression "Quantitative analyses indicated a 6-7-fold increased RNA level in HCCs versus uninvolved liver, advancing this as a molecule of interest." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 16878148 MALAT1 hepatocellular carcinoma Mutation "We conducted a case-control study and genotyped two SNPs, rs7763881 in HULC and rs619586 in MALAT1 Furthermore, the variant genotypes of rs619586 was associated with decreased HCC risk with a borderline significance." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 22493738 MALAT1 hepatocellular carcinoma Expression "Overexpressed MALAT1 was found in many solid tumors such as lung cancer, cervical cancer, and HCC." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24757675 MALAT1 kidney cancer Regulation Oncogene chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24373479 MALAT1 laryngeal squamous cell carcinoma Expression The result suggested that the MALAT1 was up-regulated in primary LSCC compared with adjacent non-cancerous tissues. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24817925 MALAT1 liver cancer Regulation Sequesters SR splicing factors to regulate alternative splicing. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 22996375 MALAT1 liver cancer Regulation "Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA, Malat1-induced tumourigenesis in liver cancer." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24468535 MALAT1 lung adenocarcinoma Expression Metastasis associated lung adenocarcinoma transcript 1 is up-regulated in placenta previa increta/percreta and strongly associated with trophoblast-like cell invasion in vitro. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 19690017 MALAT1 lung cancer Interaction MALAT-1 is a novel class of non-coding RNA that promotes cell motility of lung adenocarcinoma cells through transcriptional and post-transcriptional regulation of motility related gene expression. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 20937273 MALAT1 lung cancer Expression "Overexpressed MALAT1 was found in many solid tumors such as lung cancer, cervical cancer, and HCC." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24757675 MALAT1 lung cancer Expression "MALAT1, also known as NEAT2 (nuclear-enriched abundant transcript 2), was initially discovered as a predictive biomarker for metastasis development in lung cancer." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24667321 MALAT1 lung cancer Regulation Sequesters SR splicing factors to regulate alternative splicing. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 22996375 MALAT1 lung cancer Regulation The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 23243023 MALAT1 lung cancer Regulation "invasion & metastasis pancreas, colon, prostate liver, cervix, neuroblastoma osteosarcoma" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24499465 MALAT1 nasopharyngeal carcinoma Expression "The result found that MALAT1 was most highly expressed in 5-8F cells (high rate to be tumor and metastasis), and up-regulated in CNE-2, C666-1 and HONE-1 which is higher malignant and poorly differentiated nasopharyngeal squamous cell carcinoma, while least expressed in NP69 epithelial cells of the eternal life. The data indicated that MALAT1 might be related to the metastasis and differentiation of NPC cells." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24817925 MALAT1 neuroblastoma Expression We identified a shorter transcriptional initiation site and found that CREB binds to the defined proximal promoter of the MALAT1 gene. The expression of the tumor marker MALAT1 ncRNA is sensitive to cell surface receptor activation by oxytocin in a neuroblastoma cell line. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 20149803 MALAT1 non-small cell lung cancer Expression "In NSCLC metastasizing tumors, MALAT-1 expression is three-fold higher than in non-metastasizing tumors. Furthermore, in patients with stage I disease, MALAT-1 expression is closely correlated with poor prognosis." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 21550244 MALAT1 non-small cell lung cancer Expression "Increased expression of the lncRNA MALAT-1 has been observed in several types of tumors, including metastatic non-small cell lung cancer." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 12970751 MALAT1 non-small cell lung cancer Expression "Specific lncRNAs can serve as predictors of tumor outcome, as shown with the expression of the lncRNA MALAT-1 in early-stage non-small cell lung cancer." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 21903344 MALAT1 non-small cell lung cancer Expression The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 22088988 MALAT1 non-small cell lung cancer N/A "MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 12970751 MALAT1 non-small cell lung cancer Expression lncRNA-associated disruption to alternative splicing has also been reported in non-small cell lung cancer by virtue of overexpression of MALAT1 chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 22817756 MALAT1 osteosarcoma Expression Osteosarcoma patients' survival is significantly associated with MALAT-1 expression levels. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 20951849 MALAT1 osteosarcoma Regulation Sequesters SR splicing factors to regulate alternative splicing. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 22996375 MALAT1 pancreatic cancer Regulation Sequesters SR splicing factors to regulate alternative splicing. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 22996375 MALAT1 prostate cancer Regulation Putative marker chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24373479 MALAT1 prostate cancer Regulation Sequesters SR splicing factors to regulate alternative splicing. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 22996375 MALAT1 small cell lung cancer Expression "For other LncRNAs, specific targets have yet to be identified. This is the case of MALAT1, a LncRNA whose expression is three times higher in metastasizing early-stage non-small cell lung cancer vs. non-metastasizing tumours" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 22928560 MALAT1 TDP-43-associated pathological states Expression "Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 23791884 MALAT1 cancer Expression "Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24469926 MALAT1 cancer Regulation "MALAT1 plays a role in cell migration and tumor metastasis, as demonstrated by knockout of MALAT1 in lung cancer cell lines (Gutschner et al., 2013). " chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24721780 MALAT1 uterus cancer Regulation Sequesters SR splicing factors to regulate alternative splicing. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 22996375 MALAT1 uterus cancer Regulation "invasion & metastasis pancreas, colon, prostate liver, cervix, neuroblastoma osteosarcoma" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24499465 MAP3K14 pancreatic ductal adenocarcinoma Expression Differential expression chr2 45316960 45317040 - Human MAP3K14 ENST00000634016 22078386 MEG3 acute myeloid leukemia Epigenetics "MEG3 hypermethylation occurred in 15 MDS patients (34.9%), and in 20 AML patients (47.6%)." chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 19595458 MEG3 bladder cancer Regulation Tumour suppressor chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24373479 MEG3 bladder cancer Expression MEG3 expression is lost. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 14602737 MEG3 bladder cancer Expression Theseguilty by association studies have found numerous bladder-cancer associated lncRNAs chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24006935 MEG3 bladder cancer Regulation Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 23295831 MEG3 breast cancer Expression MEG3 expression is lost. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 14602737 MEG3 cancer N/A A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 14602737 MEG3 cancer N/A MEG3 could represent a tumor suppressor gene located in chromosome 14q32 and its association with tumorigenesis is growing every day. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 21400503 MEG3 cancer N/A MEG3 functions as a novel lncRNA tumor suppressor. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 22393162 MEG3 chronic myeloid leukemia Expression MEG3 expression is lost. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 14602737 MEG3 colon cancer Expression MEG3 expression is lost. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 14602737 MEG3 gastric cancer Expression Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24006224 MEG3 gastric cancer Regulation Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24006224 MEG3 glioma Expression Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 22234798 MEG3 hepatocellular carcinoma Expression Braconi et al. found that the expression of maternally expressed gene 3 (MEG3) is markedly reduced in four human HCC cell lines compared with normal hepatocytes and enforced expression of MEG3 in HCC cells significantly induce apoptosis. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24296588 MEG3 hepatocellular carcinoma Expression "Enforced expression of MEG3 in HCC cells significantly decreased both anchorage-dependent and -independent cell growth, and induced apoptosis. Methylation-dependent tissue-specific regulation of the lncRNA MEG3 by miR-29a may contribute to HCC growth." chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 21625215 MEG3 hepatocellular carcinoma Regulation "Expression of MEG3 in tumor cells results in growth suppression, p53 protein increase, and activation of p53 downstream targets." chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24757675 MEG3 drug abuse Mutation Intriguingly a genome-wide association study has implicated MEG3 in the vulnerability to heroin addiction. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 21128942 MEG3 Huntington's disease Expression "LncRNAs TUG1 (necessary for retinal development), and NEAT-1 (a structural component of nuclear paraspeckles) are upregulated in HD caudate, while the brain-specific tumor-suppressor MEG3 is downregulated in HD." chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 23346095 MEG3 kidney cancer Expression Tumour suppressor chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24373479 MEG3 lung cancer Expression MEG3 expression is lost. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 14602737 MEG3 meningioma Epigenetics "Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression." chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 20179190 MEG3 meningioma Regulation MEG3: a novel long noncoding potentially tumour-suppressing RNA in meningiomas. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 23307326 MEG3 myelodysplastic syndrome Epigenetics "MEG3 hypermethylation occurred in 15 MDS patients (34.9%), and in 20 AML patients (47.6%)." chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 19595458 MEG3 neuroblastoma Epigenetics MEG3-DMR is completely methylated in neuroblastoma cell lines. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 15798773 MEG3 pituitary adenoma Expression "Maternally Expressed Gene 3 (MEG3), which is specifically associated with clinically non-functioning pituitary adenomas of a gonadotroph lineage." chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 20211686 MEG3 pituitary adenoma Epigenetics Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 15644399 MEG3 pituitary adenoma Epigenetics Selective loss of MEG3 expression and intergenic differentially methylated region hypermethylation in the MEG3/DLK1 locus in human clinically nonfunctioning pituitary adenomas. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 18628527 MEG3 pituitary adenoma Expression The DLK1-MEG3 locus is silenced in NFAs (nonfunctioning adenomas). The DLK1-MEG3 locus plays a tumor suppressor role in human NFAs. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 21871428 MEG3 pituitary adenoma Expression "Another potential angiogenic lncRNA, Maternally expressed gene 3 (MEG3) was found to be silenced in pituitary adenomas." chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24829860 MEG3 prostate cancer Expression MEG3 expression is lost. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 14602737 MEG3 cancer Expression "Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior." chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24469926 MEG3 type 2 diabetes mellitus Locus The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 19966805 MESTIT1 Silver-Russell syndrome N/A Association chr7 130487057 130491172 - Human MEST-AS1; MEST-IT; MEST-IT1; NCRNA00040; PEG1-AS NR_004382 12746419 MIAT cancer Regulation Another lncRNA serving as oncogene is retinal noncoding RNA 2 (RNCR2). chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 24757675 MIAT drug abuse Expression "MIAT turned out to be one of the top twenty-five, of nearly 39,000, transcripts differentially expressed in the nucleus accumbens,a midbrain region pivotal in drug abuse, in a case-control study of human heroin and cocaine abusers." chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 20951849 MIAT drug abuse Expression The lncRNA MIAT is upregulated in heroin abusers. chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 21128942 MIAT myocardial infarction Mutation MIAT lincRNA Variants Confer Susceptibility to Myocardial Infarction chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 23104877 MIAT myocardial infarction Expression The altered expression of MIAT by the SNP may play some role in the pathogenesis of MI. chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 17066261 MIAT myocardial infarction Mutation "In vitro functional analyses revealed that the minor variant of one SNP in exon 5 increased transcriptional level of MIAT. Moreover, unidentified nuclear protein(s) bound more intensely to risk allele than non-risk allele. These results indicate that the altered expression of MIAT by the SNP may play some role in the pathogenesis of MI." chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 17066261 MIAT myocardial infarction Mutation SNPs associated with myocardial infarction localized to a haplotype block that encompassed the last 3 exons of MIAT. chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 20951849 MIAT myocardial infarction Regulation "A myocardial infarction-associated transcript (MIAT), also known as RNCR2 or Gomafu, is a long intergenic non-coding RNA that presents many genetic variants implicated in different processes. A large scale case-control association study regarding cardiovascular disease demonstrates that a MIAT variant (rs2301523) confers susceptibility to myocardial infarction." chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 24113581 MIAT schizophrenia Expression "Finally, we show that Gomafu is downregulated in post-mortem cortical gray matter from the superior temporal gyrus in SZ. " chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 23628989 MINA esophageal squamous cell carcinoma Regulation "Dysfunction of MDIG was found in several types of solid cancers including gastric carcinoma, esophageal squamous cell carcinoma, and lung cancer. Overexpression of MDIG was observed in hepatocellular carcinoma." N/A N/A N/A N/A Human N/A N/A 24757675 MINA gastric cancer Regulation "Dysfunction of MDIG was found in several types of solid cancers including gastric carcinoma, esophageal squamous cell carcinoma, and lung cancer. Overexpression of MDIG was observed in hepatocellular carcinoma." N/A N/A N/A N/A Human N/A N/A 24757675 MINA hepatocellular carcinoma Expression "Dysfunction of MDIG was found in several types of solid cancers including gastric carcinoma, esophageal squamous cell carcinoma, and lung cancer. Overexpression of MDIG was observed in hepatocellular carcinoma." N/A N/A N/A N/A Human N/A N/A 24757675 MINA lung cancer Regulation "Dysfunction of MDIG was found in several types of solid cancers including gastric carcinoma, esophageal squamous cell carcinoma, and lung cancer. Overexpression of MDIG was observed in hepatocellular carcinoma." N/A N/A N/A N/A Human N/A N/A 24757675 MIR100HG myopia Locus LOC399959 was identified within a 200-kb DNA encompassing rs577948. chr11 122089103 122203062 - Human AGD1; linc-NeD125; lncRNA-N2 NR_137175 19779542 MIR155HG chronic lymphocytic leukemia Interaction MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. chr21 25562145 25575168 + Human BIC; MIRHG2; NCRNA00172 NR_001458 21296997 MIR17HG cancer Locus Aurora kinase A induces miR-17-92 cluster through regulation of E2F1 transcription factor. chr13 91347820 91354575 + Human C13orf25; FGLDS2; LINC00048; MIHG1; MIRH1; MIRHG1; NCRNA00048; miR-17-92 NR_027349 20300951 MIR17HG lymphoma Locus C13orf25 (MIR17HG) is a target for 13q31-q32 amplification in malignant lymphoma. chr13 91347820 91354575 + Human C13orf25; FGLDS2; LINC00048; MIHG1; MIRH1; MIRHG1; NCRNA00048; miR-17-92 NR_027349 15126345 MIR17HG syndromic developmental defect Locus "Here we report the identification of germline hemizygous deletions of MIR17HG, encoding the miR-17~92 polycistronic miRNA cluster, in individuals with microcephaly, short stature and digital abnormalities." chr13 91347820 91354575 + Human C13orf25; FGLDS2; LINC00048; MIHG1; MIRH1; MIRHG1; NCRNA00048; miR-17-92 NR_027349 21892160 MIR31HG breast cancer Epigenetics miR-31 and its host gene lncRNA LOC554202 (MIR31HG) are regulated by promoter hypermethylation in triple-negative breast cancer.Both miR-31 and the host gene LOC554202 are down-regulated in the TNBC cell lines of basal subtype and over-expressed in the luminal counterparts. chr9 21454268 21559698 - Human hsa-lnc-31 NR_027054 22289355 MIR7-3HG hepatocellular carcinoma Expression "Besides, another study showed that liver cancer-downregulated lncRNA uc002mbe.2 could be induced by trichostatin A (TSA) treatment and its expression is positively correlated with the apoptotic effect of TSA in HCC cells. " chr19 4769105 4772556 + Human C19orf30; Huh7; LINC00306; NCRNA00306; PGSF1; uc002mbe.2 NR_027148 24296588 NAMA papillary thyroid carcinoma Expression "Identification of a novel noncoding RNA gene, NAMA, that is downregulated in papillary thyroid carcinoma with BRAF mutation and associated with growth arrest." chr9 99355340 99375257 - Human N/A NR_102270 17415708 SNHG16 neuroblastoma Regulation It is now becoming increasingly evident that N-myc also regulates the expression of long noncoding RNAs such as T-UCRs and ncRAN. chr17 76557764 76565348 + Human Nbla10727; Nbla12061; ncRAN NR_038111 22936790 NDM29 neuroblastoma Expression "The synthesis of a pol III-transcribed noncoding (nc) RNA (NDM29) strongly restricts NB development by promoting cell differentiation, a drop of malignancy processes. NDM29 expression leads to NB cell differentiation." N/A N/A N/A N/A Human N/A N/A 20581224 NEAT1 AIDS Expression "We found NEAT-1 to be one of several lncRNAs whose expression is changed by HIV-1 infection, and we have characterized its role in HIV-1 replication." chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 23362321 NEAT1 amyotrophic lateral sclerosis Regulation The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 23835137 NEAT1 frontotemporal lobar degeneration Interaction Analysis of RNA binding by TDP-43 in brains from subjects with FTLD revealed that the greatest increases in binding were to the MALAT1 and NEAT-1 noncoding RNAs. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 20581224 NEAT1 Huntington's disease Expression "LncRNAs TUG1 (necessary for retinal development), and NEAT-1 (a structural component of nuclear paraspeckles) are upregulated in HD caudate, while the brain-specific tumor-suppressor MEG3 is downregulated in HD." chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 23346095 NEAT1 intrauterine growth restriction Expression "The long non-coding RNA NEAT-1 is increased in IUGR placentas, leading to potential new hypotheses of IUGR origin/development." chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 24280234 NEAT1 TDP-43-associated pathological states Expression "Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms" chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 23791884 NEAT1 oral squamous cell carcinoma Expression "Subsequently, they confirmed that the expression levels of HOTAIR, NEAT-1 and UCA2 in metastasized samples was prominent higher than the non-metastatic samples." chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 24817925 np_17856 progressive kidney injury Regulation Real-time PCR confirmed these findings and revealed the functional link between Smad3-dependent lncRNAs np_5318/np_17856 and progressive kidney injury. N/A N/A N/A N/A Mouse N/A N/A 24262754 np_5318 progressive kidney injury Regulation Real-time PCR confirmed these findings and revealed the functional link between Smad3-dependent lncRNAs np_5318/np_17856 and progressive kidney injury. N/A N/A N/A N/A Mouse N/A N/A 24262754 NPPA-AS1 cardiovascular disease N/A The NPPA-AS lncRNA has been shown to be a modulator of the alternative splicing of the NPPA gene. This lncRNA thus has potential to be involved in cardiovascular disease chr1 11840319 11847616 + Human NPPA-AS; NPPAAS NR_037806 22817756 NPTN-IT1 colorectal cancer Expression "In this study, we found that the lncRNA Low Expression in Tumor (lncRNA-LET) was generally downregulated in hepatocellular carcinomas, colorectal cancers, and squamous-cell lung carcinomas." chr15 73566938 73569543 - Human lncRNA-LET NR_103844 23395002 NPTN-IT1 hepatocellular carcinoma Expression "Importantly, another lncRNA-LET (lncRNA low expression in tumor) is found to play a critical role in hypoxia-induced metastasis in HCC " chr15 73566938 73569543 - Human lncRNA-LET NR_103844 24296588 NPTN-IT1 hepatocellular carcinoma Expression "In this study, we found that the lncRNA Low Expression in Tumor (lncRNA-LET) was generally downregulated in hepatocellular carcinomas, colorectal cancers, and squamous-cell lung carcinomas." chr15 73566938 73569543 - Human lncRNA-LET NR_103844 23395002 NPTN-IT1 squamous cell lung carcinoma Expression "In this study, we found that the lncRNA Low Expression in Tumor (lncRNA-LET) was generally downregulated in hepatocellular carcinomas, colorectal cancers, and squamous-cell lung carcinomas." chr15 73566938 73569543 - Human lncRNA-LET NR_103844 23395002 NRON Down's syndrome Expression "NRON is a lncRNA that mediates the cytoplasmic to nuclear shuttling of the NFAT transcription factor . In animal models, deregulation of the DSCR1 and DYRK1A genes act synergistically to prevent nuclear occupancy of NFATc transcription factors leading to reduced NFATc activity and to many features of DS, suggesting a potential link between NRON activity and DS pathophysiology." chr9 126407775 126410504 - Human NCRNA00194 NR_045006 16141075 PAN Kaposi's sarcoma Expression KSHV infected cells express a highly abundant long noncoding transcript referred to as polyadenylated nuclear RNA (PAN RNA). N/A N/A N/A N/A Human N/A N/A 23468496 PANDAR p53-associated pathological states Expression "Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms" chr6 36673621 36675126 - Human PANDA NR_109836 23791884 PANDAR cancer Expression "Another DNA damage-responsive, p53-induced lncRNA that lies upstream of p21, PANDA (P21 associated ncRNA DNA damage activated), is also implicated in the repression of pro-apoptotic genes, such as FAS and BIK, by acting as a decoy for the transcription factor NF-YA. In some cancer types, p53 mutations have been found that maintain the protein's ability to induce the PANDA pathway (and its antiapoptotic effects) while abolishing its ability to induce p21 and its promotion of cell-cycle arrest, thus leading to increased tumor cell survival (Hung et al. 2011). " chr6 36673621 36675126 - Human PANDA NR_109836 23463798 PCA3 prostate cancer Expression Diagnostic marker chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 24373479 PCA3 prostate cancer Expression A PCA3 score threshold of 20 may have the highest utility for selecting men with clinically insignificant prostate cancer in whom active surveillance may be appropriate; a PCA3 score threshold of 50 may be used to identify men at high risk of harbouring significant prostate cancer who are candidates for RP. chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 21883822 PCA3 prostate cancer Expression It was found that the levels of the mRNA expression of DD3(PCA3) were significantly higher (p<0.045) in patients with PCa than in patients with benign prostatic hyperplasia. chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 20332487 PCA3 prostate cancer Expression Measurement of lncRNA PCA3 in patient urine samples has been shown to allow more sensitive and specific diagnosis of prostate cancer than the widely used marker prostate-specific antigen (PSA). chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 15245811 PCA3 prostate cancer Expression PCA3 is a highly prostate cancer-specific gene. chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 14607216 PCA3 prostate cancer Expression "PCA3 is one of the most prostate cancer-specific genes yet described, and this makes DD3 a promising marker for the early diagnosis of prostate cancer and provides a powerful tool for the development of new treatment strategies for prostate cancer patients." chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 10606244 PCA3 prostate cancer Expression PCA3 mRNA is prostate cancer specific and shows increased expression in prostate cancer. chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 20114043 PCA3 prostate cancer Expression PCA3 scores were significantly lower in low-volume disease and insignificant PCa. Higher PCA3 scores were associated with aggressive disease. chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 20980098 PCA3 prostate cancer Expression Patients with a positive biopsy showed significantly higher PCA3 values. chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 20424427 PCA3 prostate cancer Expression "The PCA3 assay is insensitive to pre-analytical factors, performs well analytically and correctly classifies a high percent of subjects with known prostate cancer status across research sites." chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 18054202 PCA3 prostate cancer Expression The probability of a positive repeat biopsy increases with rising PCA3 scores. The PCA3 score was superior to %fPSA for predicting repeat prostate biopsy outcome and may be indicative of clinical stage and significance of pCa. chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 18602209 PCA3 prostate cancer Expression Upregulation of two new PCA3 isoforms in PCa tissues improves discrimination between PCa and BPH. chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 19319183 PCA3 prostate cancer Mutation The presence of the (TAAA)n short tandem repeat polymorphisms in the PCA3 promoter region may be a risk factor for prostate cancer in the Chinese population. chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 21655300 PCA3 prostate cancer N/A "PCGEM1, PCA3 (prostate cancer antigen 3, known also as DD3, differential display code 3) and PCNCR1 (prostate cancer ncRNA 2) are involved in prostate cancer, while HULC (highly up-regulated in liver cancer) is involved with liver cancer." chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 24667321 PCAT1 cancer Regulation "PCAT1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer." chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 24473064 PCAT1 prostate cancer Regulation "They described PCAT1,a novel PCa lincRNA on 8q24, in the locality of well-characterized PCa risk-related SNPs and the c-MYC oncogene." chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 24146262 PCAT1 prostate cancer Expression Putative marker and oncogene chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 24373479 PCAT1 prostate cancer Expression "PCAT1 is markedly overexpressed in a subset of prostate cancers, particularly metastases, and may contribute to cell proliferation in these tumors." chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 21804560 PCAT1 prostate cancer Interaction PCAT1 is a prostate-specific regulator of cell proliferation and show that it is a target of the Polycomb Repressive Complex 2 (PRC2). Patterns of PCAT1 and PRC2 expression stratified patient tissues into molecular subtypes distinguished by expression signatures of PCAT1-repressed target genes. chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 21804560 PCAT1 prostate cancer Regulation "The prostate cancer-associated ncRNA transcript 1 lncRNA PCAT1, SchlAP1 (second chromosome locus associated with prostate-1), and CTBP1-AS indicate cancer cell invasiveness and metastasis in prostate cancer progression. " chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 24531795 PCAT1 prostate cancer Regulation "The prostate cancer-associated ncRNA transcript 1 lncRNA PCAT1, SchlAP1 (second chromosome locus associated with prostate-1), and CTBP1-AS indicate cancer cell invasiveness and metastasis in prostate cancer progression. " chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 24531795 PCAT1 prostate cancer Regulation "For example, a recent RNA-Seq study in prostate cancer tissues and cell lines uncovered a lncRNA, PCAT1, that promotes cell proliferation and is a target of PRC2 regulation." chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 21804560 PCGEM1 prostate cancer Regulation "One of the earliest lncRNAs described in PCa, was PCGEM1(prostate cancer gene expression marker 1), a prostate-specific transcript encoded on 2q32 (40). One of the earliest lncRNAs described in PCa, was PCGEM1 (prostate cancer gene expression marker 1), a prostate-specific transcript encoded on 2q32 (40). " chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 24146262 PCGEM1 prostate cancer Regulation High-risk and predictive marker Oncogene chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 24373479 PCGEM1 prostate cancer Expression "Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients." chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 14724589 PCGEM1 prostate cancer Expression Expression profiles of genes in CRPC support a role for the transcriptional activity of the PCGEM1. chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 20868494 PCGEM1 prostate cancer Expression PCGEM1 was originally discovered in a genome-wide gene expression screen as a cDNA sequence with prostate cancer overexpression and highly specific localization to glandular epithelial cells. chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 20951849 PCGEM1 prostate cancer Expression "PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer." chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 11050243 PCGEM1 prostate cancer Expression "The biomarkers had sensitivities ranging from 91% to 100%. Clinical specificities evaluated with the BPH tissue were the following: hTERT mRNA (93%), DD3 mRNA (57%), Survivin (29%) and PCGEM1 (14%)." chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 16515751 PCGEM1 prostate cancer Interaction "Phytosterol inhibition of PCGEM1 and cell growth and the overexpression of caveolin-1, suggests that poor disease prognosis anchors on the ability of caveolin-1 to regulate downstream oncogene(s) and apoptosis genes." chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 19186008 PCGEM1 prostate cancer N/A "A prostate-specific and prostate cancer-associated noncoding gene, PCGEM1 regulates apoptosis." chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 16569192 PCGEM1 prostate cancer N/A "PCGEM1, PCA3 (prostate cancer antigen 3, known also as DD3, differential display code 3) and PCNCR1 (prostate cancer ncRNA 1) are involved in prostate cancer, while HULC (highly up-regulated in liver cancer) is involved with liver cancer." chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 24667321 PCGEM1 prostate cancer Expression "Here we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 (also known as PCAT8) and PCGEM1, bind successively to the androgen receptor and strongly enhance both ligand-dependent and ligand-independent androgen-receptor-mediated gene activation programs and proliferation in prostate cancer cells. " chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 23945587 PCGEM1 prostate cancer Mutation "We found a significantly decreased risk of PCa for rs6434568 AC and AC/AA genotype, as well as rs16834898 AC and AC/CC genotype, compared with the CC and AA genotypes, respectively." chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 23459097 PCGEM1 prostate cancer Regulation "The focus of this Nature report13 is on two PCa-associated lncRNAs: PCGEM1 and PRNCR1. They cooperate in regulating the function of the male hormone receptor, the androgen receptor (AR), which plays central role in PCa onset and progression. AR pathway is activated in advanced CaPs including castration-resistant prostate cancer (CRPC)." chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 24713835 PCNA-AS1 cancer Regulation Antisense long non-coding RNA PCNA-AS1 promotes tumor growth by regulating proliferating cell nuclear antigen in hepatocellular carcinoma. chr20 5119586 5119969 + Human PCNA-AS; PCNAAS NR_028370 24704293 PCNCR1 prostate cancer N/A Accumulating evidence indicated that prostate cancer non-coding RNA 1 (PCNCR1) lncRNA was identified in a gene deserton chromosome 8q24.2 and is associated with susceptibility to prostate cancer N/A N/A N/A N/A Human N/A N/A 22535282 PCNCR1 prostate cancer N/A "PCGEM1, PCA3 (prostate cancer antigen 3, known also as DD3, differential display code 3) and PCNCR1 (prostate cancer ncRNA 3) are involved in prostate cancer, while HULC (highly up-regulated in liver cancer) is involved with liver cancer." N/A N/A N/A N/A Human N/A N/A 24667321 PDZRN3-AS1 type 2 diabetes mellitus Mutation SNP rs11128347 (C>G) in PDZRN3 is associated with African-Americans with type 2 diabetes. chr3 73623568 73627899 + Human N/A NR_046681 21546767 Pinc breast cancer N/A "In a finding of relevance to breast cancer pathogenesis, the mammary gland lncRNA PINC, whose genomic structure is substantially different between primates and rodents has been shown to function in both cell survival and cell cycle progression." chr1 73391385 73407569 - Mouse N/A NR_003202 20951849 PINK1-AS diabetes mellitus Expression "As the name suggests, PINK1 is induced by PTEN, which is an important inhibitor of insulin signalling. PINK1 depletion has been associated with diabetes status, impaired glucose uptake in neuronal cell lines and with mitochondrial gene expression in adipocytes , raising the possibility that disruption to naPINK1 may impact on glucose metabolism. " chr1 20642657 20652193 - Human NAPINK11; PINK1AS; PINK1-AS NR_046507 22817756 PINK1-AS Parkinson's disease Interaction Mutations in the PTEN induced putative kinase 1 (PINK1) are implicated in early-onset Parkinson's disease. Welective targeting of naPINK1 results in loss of the PINK1 splice variant in neuronal cell lines. chr1 20642657 20652193 - Human NAPINK11; PINK1AS; PINK1-AS NR_046507 17362513 PISRT1 blepharophimosis syndrome Mutation "The blepharophimosis syndrome (BPES) is driven by dysregulation of the FOXL2 gene, numerous extragenic mutations have been reported in patients. One particular deletion occurring 283 kb away from FOXL2 disrupts a lncRNA, PISRT1, that was shown by chromatin confirmation capture to physically loop with FOXL2." chr3 139232992 139233522 - Human NCRNA00195 NR_027070 20930520 PRNCR1 prostate cancer Regulation "That same year, Chung et al reported PCa susceptibility SNPs within a 13 kb intron-less lincRNA also on 8q24, which they termed PRNCR1." chr8 127079874 127092595 + Human CARLo-3; PCAT8 NR_109833 24146262 PRNCR1 prostate cancer Regulation Susceptibility marker oncogene chr8 127079874 127092595 + Human CARLo-3; PCAT8 NR_109833 24373479 PRNCR1 prostate cancer Expression "Here we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 (also known as PCAT8) and PCGEM1, bind successively to the androgen receptor and strongly enhance both ligand-dependent and ligand-independent androgen-receptor-mediated gene activation programs and proliferation in prostate cancer cells. " chr8 127079874 127092595 + Human CARLo-3; PCAT8 NR_109833 23945587 PRNCR1 prostate cancer Regulation "The focus of this Nature report13 is on two PCa-associated lncRNAs: PCGEM1 and PRNCR1. They cooperate in regulating the function of the male hormone receptor, the androgen receptor (AR), which plays central role in PCa onset and progression. AR pathway is activated in advanced CaPs including castration-resistant prostate cancer (CRPC)." chr8 127079874 127092595 + Human CARLo-3; PCAT8 NR_109833 24713835 PSORS1C3 psoriasis N/A Psoriasis susceptibility 1 candidate 3 chr6 31173735 31177899 - Human NCRNA00196 NR_026816 15848982 PSORS1C3 psoriasis Mutation "The PSORS1C3*582A allele, an SNP in the 3'-untranslated region of the PSORS1C3 gene, was a major psoriasis vulgaris susceptibility allele in the Chinese population, and the association was much stronger in patients with early-onset psoriasis vulgaris." chr6 31173735 31177899 - Human NCRNA00196 NR_026816 16965413 PTCSC1 papillary thyroid carcinoma Locus papillary thyroid carcinoma susceptibility candidate chr8 133054959 133057767 - Human NCRNA00197; PTCSC NR_146773 19147577 PTCSC3 papillary thyroid carcinoma Expression The study showed that the expression of PTCSC3 in six thyroid cancer cell lines is lower and no expression was detected in any of them. chr14 36135710 36176651 - Human N/A NR_049735 24817925 PTCSC3 papillary thyroid carcinoma Mutation "A thyroid-specific lncRNA, termed PTC susceptibility candidate 3 (PTCSC3), that was strongly downregulated in PTC was identified in this region and it was found that the repression was caused by the associated SNP. " chr14 36135710 36176651 - Human N/A NR_049735 23660942 PTENP1 cancer Regulation PTENP1 pseudogene belongs to the group of competing endogenous RNAs (ceRNAs). It may act as “decoy?by protecting PTEN mRNA from binding to common miRNA and therefore allowing expression of the tumor suppressor protein. chr9 33673504 33677499 - Human PTENP1 ENST00000532280 24757675 PTENP1 prostate cancer Regulation Oncogene; tumour suppressor chr9 33673504 33677499 - Human PTENP1 ENST00000532280 24373479 PTENP1 cancer Regulation An example of this mechanism is represented by the tumour suppressor gene PTEN and its pseudogene PTENP1. chr9 33673504 33677499 - Human PTENP1 ENST00000532280 23660942 PTENpg1 cancer Regulation "PTEN is a tumor-suppressor gene that has been shown to be under the regulatory control of a PTEN pseudogene expressed noncoding RNA, PTENpg1." N/A N/A N/A N/A Human N/A BX374997.2 23435381 PVT1 breast cancer Expression Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 17908964 PVT1 Burkitt lymphoma Mutation PVT1 is frequently involved in the translocations occurring in variant Burkitt's lymphomas and murine plasmacytomas. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 17503467 PVT1 cancer Expression The PVT gene frequently amplifies with MYC in tumor cells. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 2725491 PVT1 cleft lip Mutation "Association identified by GWAS (rs987525,A>G)." chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 19270707 PVT1 diabetic nephropathy Interaction PVT1 may mediate the development and progression of diabetic nephropathy through mechanisms involving ECM accumulation. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 21526116 PVT1 diabetic nephropathy Regulation "Role of MicroRNA 1207-5P and Its Host Gene, the Long Non-Coding RNA Pvt1, as Mediators of Extracellular Matrix Accumulation in the Kidney: Implications for Diabetic Nephropathy." chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 24204837 PVT1 Hodgkin's lymphoma N/A PVT1 is a new susceptibility loci for this disease. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 21037568 PVT1 lymphoma N/A Burkitt lymphoma association chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 3024964 PVT1 lymphoma N/A Burkitt lymphoma association chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 2470097 PVT1 plasmacytoma Mutation PVT1 is frequently involved in the translocations occurring in variant Burkitt's lymphomas and murine plasmacytomas. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 17503467 PVT1 ovarian cancer Expression Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 17908964 PVT1 pancreatic cancer Expression PVT1 gene as a regulator of Gemcitabine sensitivity and showed that functional inactivation of the PVT1 gene led to enhanced Gemcitabine sensitivity in human pancreatic cancer ASPC-1 cells. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 21316338 PVT1 prostate cancer Mutation "The risk allele (G) of rs378854 (A>G) reduces binding of the transcription factor YY1 in vitro. The region surrounding rs378854 interacts with the MYC and PVT1 promoters.Expression of the PVT1 oncogene in normal prostate tissue increased with the presence of the risk allele of rs378854, while expression of MYC was not affected." chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 21814516 PVT1 kidney cancer Mutation "Variants (rs13447075, A>C;rs2648862, A>C) in the plasmacytoma variant translocation gene (PVT1) are associated with end-stage renal disease attributed to type 1 diabetes." chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 17881614 PVT1 type 2 diabetes mellitus Mutation "There is association between variants (rs2720709, A>G) in the plasmacytoma variant translocation 1 gene (PVT1) and end-stage renal disease (ESRD) attributed to both type 1 and type 2 diabetes." chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 21526116 PVT1 type 2 diabetes mellitus Mutation "Identification of PVT1 (rs2720709, A>G) as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study." chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 17395743 PVT1 type 2 diabetes mellitus Mutation "There is association between variants (rs2720709, A>G) in the plasmacytoma variant translocation 1 gene (PVT1) and end-stage renal disease (ESRD) attributed to both type 1 and type 2 diabetes." chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 21526116 REST/CoREST-regulated lncRNAs Huntington's disease Expression "Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms" N/A N/A N/A N/A Human N/A N/A 23791884 RMST rhabdomyosarcoma Expression NCRMS (RMST) on chromosome 12q21 shows differential expression between rhabdomyosarcoma subtypes. chr12 97465021 97533766 + Human LINC00054; NCRMS; NCRNA00054 NR_024037 12082533 RNA polymerase III-dependent lncRNAs diffuse cerebral hypomyelination Expression "Biogenesis, metabolism, and functions of lncRNAs are otherwise interconnected with known pathogenic mechanisms" N/A N/A N/A N/A Human N/A N/A 23791884 RNA-a Opitz-Kaveggia syndrome Regulation "A recent study indicated that a subset of long ncRNAs, called activating long ncRNAs (RNA-a), is associated with Opitz–Kaveggia (also known as FG) syndrome, a X-linked intellectual disability syndrome, characterized by various neuronal pathologies as well as developmental abnormalities." N/A N/A N/A N/A Human N/A N/A 24624135 RNase MRP cartilage hair hypoplaisia Mutation "Point mutations in RNase MRP cause human Cartilage Hair Hypoplaisia (CHH), and several disease-causing mutations map to RMRP-S1 and -S2. SHAPE chemical probing identified two alternative secondary structures altered by disease mutations." N/A N/A N/A N/A Human N/A N/A 24009312 RP1-179N16.3 nasopharyngeal carcinoma Expression "Six lncRNAs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294006) were confirmed by qPCR." chr6 36091991 36092646 - Human Z95152.1 ENST00000453556 24379026 RP4-620F22.3 enterovirus 71 infection Expression "A general consistency between the qPCR and microarray analysis results was confirmed in four lncRNAs (AP000688.29, AC002511.1, RP5-843L14.1, and RP4-620F22.3) in terms of regulation direction and significance. Specifically, a 3.31-fold down-regulation " chr1 89289676 89290337 - Human AC099063.2 ENST00000446360 23220233 RP5-843L14.1 enterovirus 71 infection Expression "A general consistency between the qPCR and microarray analysis results was confirmed in four lncRNAs (AP000688.29, AC002511.1, RP5-843L14.1, and RP4-620F22.3) in terms of regulation direction and significance. Specifically, a 3.31-fold down-regulation " chr20 56577563 56598621 + Human LINC01716 ENST00000437350 23220233 RUNXOR malignant hematopoiesis Regulation RUNXOR utilizes its 3'-terminal fragment to directly interact with the RUNX1 promoter and enhancers and participates in the orchestration of an intrachromosomal loop. The 3' region of RUNXOR also participates in long-range interchromosomal interactions with chromatin regions that are involved in multiple RUNX1 translocations. N/A N/A N/A N/A Human N/A N/A 24752773 Scarb2 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 18 downregulated in HF hearts as compared with control hearts. N/A N/A N/A N/A Mouse N/A AK036863.1 24205036 SCHLAP1 prostate cancer Expression Prensner et al found that the lncRNA SChLAP1 was overexpresed in prostate tumors and where it is critical for tumor cell metastasis. chr2 180692104 180916939 + Human LINC00913; PCAT11; PCAT114 NR_104319 24829860 Sema3g ischaemia-reperfusion injury Expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. N/A N/A N/A N/A Mouse N/A AK087277.1 24312245 SLC7A2-IT1A/B progressive encephalopathy with severe infantile anorexia Mutation Genetic variation in lncRNA genes causes disease and influences susceptibility N/A N/A N/A N/A Human N/A N/A 23791884 SNHG11 obesity Mutation New gene associated with obesity. chr20 38446654 38450921 + Human C20orf198; LINC00101; NCRNA00101 NR_003239 20532202 SNHG16 bladder cancer Regulation "putative diagnostic, prognostic, and predictive marker " chr17 76557764 76565348 + Human Nbla10727; Nbla12061; ncRAN NR_038111 24373479 SNHG16 colorectal cancer Expression "Down-regulation of ncRAN, a long non-coding RNA, contributes to colorectal cancer cell migration and invasion and predicts poor overall survival for colorectal cancer patients." chr17 76557764 76565348 + Human Nbla10727; Nbla12061; ncRAN NR_038111 24519959 SNHG3 Alzheimer's disease Expression "We selected three differential signature genes specific for the early stage (Nudt19, Arl16, Aph1b), five common to both groups (Slc15a2, Agpat5, Sox2ot, 2210015, D19Rik, Wdfy1), and seven specific for late stage." chr1 28505943 28510892 + Human NCRNA00014; RNU17C; RNU17D; U17HG; U17HG-A; U17HG-AB NR_036473 21961160 SNHG4 myelodysplastic syndrome Mutation Association identified by GWAS. chr5 139273752 139283184 + Human NCRNA00059; U19H NR_036536 19240791 SNHG5 lymphoma Locus snhg5 is located at the breakpoint of chromosomal translocation t(3;6)(q27;q15) involved in human B-cell lymphoma. chr6 85677007 85678733 - Human C6orf160; LINC00044; NCRNA00044; U50HG; bA33E24.2 NR_003038 10792466 SOX2-OT esophageal squamous cell carcinoma Expression "The results revealed a significant co-upregulation of SOX2OT along with SOX2 and OCT4 in tumor samples, compared to the non-tumor tissues obtained from the margin of same tumors. Therefore, the SOX2 gene might be a indicator for the early diagnosis of ESCC." chr3 181056680 181742228 + Human NCRNA00043; SOX2OT NR_075089 24817925 SOX2-OT Alzheimer's disease Expression "We selected three differential signature genes specific for the early stage (Nudt19, Arl16, Aph1b), five common to both groups (Slc15a2, Agpat5, Sox2ot, 2210015, D19Rik, Wdfy1), and seven specific for late stage (D14Ertd449, Tia1, Txnl4, 1810014B01Rik)." chr3 181056680 181742228 + Human NCRNA00043; SOX2OT NR_075089 21961160 SOX2-OT neurodevelopmental syndrome Regulation Genomic context links lncRNAs to disease genes/loci and related pathways chr3 181056680 181742228 + Human NCRNA00043; SOX2OT NR_075089 23791884 Sox4 ischaemia-reperfusion injury Expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. N/A N/A N/A N/A Mouse N/A AK054386.1 24312245 SPRY4-IT1 esophageal squamous cell carcinoma Expression Long noncoding RNA SPRY4-IT1 is upregulated in esophageal squamous cell carcinoma and associated with poor prognosis. chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 24810925 SPRY4-IT1 melanoma N/A The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion. chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 21558391 SPRY4-IT1 melanoma Expression Another elegant study by Khaitan et al. utilized a non-coding RNA microarray approach to identify differentially regulated lncRNAs in melanoma cells and identified a 687 bp single exon lncRNA named SPRY4-IT1 which was highly up-regulated in melanoma patient samples and cell lines. chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 24115003 SPRY4-IT1 melanoma Expression "The lncRNA, SPRY4-IT1, which is up-regulated in human melanomas compared to melanocytes and keratinocytes, affects cell dynamics, including increased rate of wound closure upon ectopic expression." chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 22492512 Srsf9 ischaemia-reperfusion injury Expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. N/A N/A N/A N/A Mouse N/A N/A 24312245 SUMO1P3 gastric cancer Expression "Pseudogene-expressed lncRNAs are a major member of the lncRNA family. Recently, our group reported that small ubiquitin-like modifier (SUMO) 1 pseudogene 3, SUMO1P3, was markedly up-regulated in gastric cancer tissues compared with paired adjacent non-tumor tissues." chr1 160317403 160317706 + Human SUMO1P3 ENST00000439961 24833871 SUMO1P3 gastric cancer Regulation Up-regulation of SUMO1 pseudogene 3 (SUMO1P3) in gastric cancer and its clinical association. chr1 160317403 160317706 + Human SUMO1P3 ENST00000439961 23996296 TC0100223 cancer Expression "Notably, three candidates (TC0100223, TC0101686 and TC0101441) were aberrantly expressed in ERα-positive compared to ERα-negative EOC tissues, showing correlations with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade." N/A N/A N/A N/A Human N/A N/A 24481591 TC0101441 cancer Expression "Notably, three candidates (TC0100223, TC0101686 and TC0101441) were aberrantly expressed in ERα-positive compared to ERα-negative EOC tissues, showing correlations with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade." N/A N/A N/A N/A Human N/A N/A 24481591 TC0101686 cancer Expression "Notably, three candidates (TC0100223, TC0101686 and TC0101441) were aberrantly expressed in ERα-positive compared to ERα-negative EOC tissues, showing correlations with some malignant cancer phenotypes such as advanced FIGO stage and/or high histological grade." N/A N/A N/A N/A Human N/A N/A 24481591 TCL6 leukemia N/A T-cell leukemia/lymphoma 6 chr14 95651178 95673452 + Human TNG1; TNG2 NR_028288 10851082 TCL6 lymphoma N/A T-cell leukemia/lymphoma 6 chr14 95651178 95673452 + Human TNG1; TNG2 NR_028288 10851082 TDRG1 testicular cancer Expression The significantly reduced expression of the TDRG1 in patients with seminoma or teratoma indicates that TDRG1 may be a candidate cancer suppressor gene. chr6 40378424 40379892 + Human LINC00532 NR_024015 21243750 TERC dyskeratosis congenita Mutation "Mutations that alter the equilibrium between different conformational states of TERCs result in disease states such as dyskeratosis congenita, presumably through disruptions of the RNA scaffold structure into which are plugged modular binding sites for telomeric regulatory proteins." chr3 169764610 169765060 - Human DKCA1; PFBMFT2; SCARNA19; TR; TRC3; hTR NR_001566 14630939 TERC prostate cancer Expression "TERC is expressed in all human tissues regardless of telomerase activity, whereas TERT is highly expressed in >90% of tumor cells" chr3 169764610 169765060 - Human DKCA1; PFBMFT2; SCARNA19; TR; TRC3; hTR NR_001566 24146262 TERRA cancer Regulation "In many cancer cells TERRA is downregulated, providing a possible link to the longevity of cancer cells by telomerase-mediated lengthening of chromosomal ends." N/A N/A N/A N/A Mouse N/A N/A 23660942 THRIL Kawasaki disease Expression "Finally, THRIL expression was correlated with the severity of symptoms in patients with Kawasaki disease, an acute inflammatory disease of childhood. " chr12 125025443 125027423 - Human BRI3BP-AS1; BRI3BPAS1; Linc1992; TCONS_00020260 NR_110375 24371310 THRIL Kawasaki disease Regulation "Finally, THRIL expression was correlated with the severity of symptoms in patients with Kawasaki disease, an acute inflammatory disease of childhood. " chr12 125025443 125027423 - Human BRI3BP-AS1; BRI3BPAS1; Linc1992; TCONS_00020260 NR_110375 24371310 TINCR squamous cell carcinoma Expression "Interestingly, the lncRNA TINCR, which is highly induced during keratinocyte differentiation, is repressed in squamous cell carcinoma specimens compared to normal adjacent epidermis." chr19 5558167 5568034 - Human LINC00036; NCRNA00036; PLAC2; onco-lncRNA-16 NR_027064 24115003 TRAF3IP2-AS1 schizophrenia N/A Association chr6 111483472 111602295 + Human C6UAS; C6orf3; NCRNA00248; TRAF3IP2-AS2 NR_034110 10903453 Trp53cor1 cancer Regulation "They identified lincRNA-p21 as a direct p53 target. Furthermore, they found that lincRNA-p21 is critical in regulating many of the genes that are repressed in response to p53 activity and they found that lincRNA-p21 associates with hnRNP-K. The lincRNA-p21/hnRNP-K interaction was found to be necessary for hnRNP-K genomic localization at sites of gene repression." chr17 29057474 29079126 - Mouse Gm16197; linc-p21; lincRNA-p21 NR_036469 24829860 Trp53cor1 cancer Expression "lincRNA-p21 (named for its vicinity to the CDKN1A/p21 locus) is upregulated by p53 upon DNA damage and implicated in downstream repressive effects of the p53 pathway, particularly on genes regulating apoptosis, possibly by directing the recruitment of hnRNP-K to its genomic targets." chr17 29057474 29079126 - Mouse Gm16197; linc-p21; lincRNA-p21 NR_036469 23463798 Trp53cor1 colorectal cancer Regulation LincRNA-p21 enhances the sensitivity of radiotherapy for human colorectal cancer by targeting the Wnt/β-catenin signaling pathway. chr17 29057474 29079126 - Mouse Gm16197; linc-p21; lincRNA-p21 NR_036469 24573322 Trp53cor1 colorectal cancer Regulation LincRNA-p21 enhances the sensitivity of radiotherapy for human colorectal cancer by targeting the Wnt/β-catenin signaling pathway. chr17 29057474 29079126 - Mouse Gm16197; linc-p21; lincRNA-p21 NR_036469 24573322 Trp53cor1 cancer Regulation "ANRIL, GAS5 and lincRNA-p23 are involved in the escape of growth suppression by regulating tumor suppressor genes (ANRIL) or apoptosis regulators." chr17 29057474 29079126 - Mouse Gm16197; linc-p21; lincRNA-p21 NR_036469 24667321 Trp53cor1 cancer Regulation Global gene regulation p53 repression via hnRNP-K; inducing cellular apoptosis chr17 29057474 29079126 - Mouse Gm16197; linc-p21; lincRNA-p21 NR_036469 24499465 Trpm3 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 25 downregulated in HF hearts as compared with control hearts. N/A N/A N/A N/A Mouse N/A AK139989.1 24205036 T-UCRs neuroblastoma Regulation It is now becoming increasingly evident that N-myc also regulates the expression of long noncoding RNAs such as T-UCRs and ncRAN. N/A N/A N/A N/A Human N/A N/A 22936790 TUG1 B-cell neoplasms Expression "HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients." chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 24583225 TUG1 bladder cancer Regulation Putative diagnostic and prognostic marker; oncogene chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 24373479 TUG1 bladder cancer Expression Theseguilty by association studies have found numerous bladder-cancer associated lncRNAs chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 24006935 TUG1 bladder cancer Expression Long intergenic non-coding RNA TUG1 is overexpressed in urothelial carcinoma of the bladder. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 22961206 TUG1 Huntington's disease Expression "LncRNAs TUG1 (necessary for retinal development), and NEAT-1 (a structural component of nuclear paraspeckles) are upregulated in HD caudate, while the brain-specific tumor-suppressor MEG3 is downregulated in HD." chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 23346095 TUG1 Huntington's disease Expression "TUG1 is upregulated in Huntington's disease brains, which is from the reanalysis of the Affymetrix U133A and B microarray data on normal and HD brains in this review." chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 22202438 TUG1 non-small cell lung cancer Regulation "P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression." chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 24853421 TUSC8 cervical cancer Expression Low expression of long noncoding XLOC_010588 indicates a poor prognosis and promotes proliferation through upregulation of c-Myc in cervical cancer. chr13 44400250 44405984 - Human LINC01071; XLOC_010588 NR_104174 24667250 U1 spliceosomal lncRNA Parkinson's disease Expression "These included the U1 spliceosomal lncRNA and RP11-462G22.1, each entailing sequence complementarity to numerous microRNAs." N/A N/A N/A N/A Human N/A N/A 24651478 SNHG14 Angelman syndrome Locus "Ube3a-as is a lncRNA transcribed antisense to the maternally expressed Ube3a gene, a candidate gene for AS, suggesting that Ube3a-as may be responsible for repressing paternal Ube3a expression." chr15 24823608 25419461 - Human 115HG; IC-SNURF-SNRPN; LNCAT; NCRNA00214; U-UBE3A-ATS; UBE3A-AS; UBE3A-AS1; UBE3AATS NR_146177 20380817 SNHG14 Angelman syndrome Expression "Prader–Willi and Angelman syndromes, due to UBE3A expression, are affected due to the presence of a 20-kb NAT, which shares complementary sequences of UBE3A" chr15 24823608 25419461 - Human 115HG; IC-SNURF-SNRPN; LNCAT; NCRNA00214; U-UBE3A-ATS; UBE3A-AS; UBE3A-AS1; UBE3AATS NR_146177 23781896 SNHG14 Angelman syndrome Mutation "Although in the majority of human tissues, both copies of the UBE3A gene are expressed, in neurons one copy is silenced by UBE3A-AS1 (ubiquitin-protein ligase E3A antisense RNA 1). In patients suffering from Angelman syndrome, the other (active) allele has either been deleted or inactivated." chr15 24823608 25419461 - Human 115HG; IC-SNURF-SNRPN; LNCAT; NCRNA00214; U-UBE3A-ATS; UBE3A-AS; UBE3A-AS1; UBE3AATS NR_146177 24667321 SNHG14 Prader-Willi syndrome Expression "Prader–Willi and Angelman syndromes, due to UBE3A expression, are affected due to the presence of a 20-kb NAT, which shares complementary sequences of UBE3A" chr15 24823608 25419461 - Human 115HG; IC-SNURF-SNRPN; LNCAT; NCRNA00214; U-UBE3A-ATS; UBE3A-AS; UBE3A-AS1; UBE3AATS NR_146177 23781896 UBE3A-ATS Angelman syndrome Regulation Genomic context links lncRNAs to disease genes/loci and related pathways N/A N/A N/A N/A Human N/A N/A 23791884 UBE3A-ATS Angelman syndrome Regulation "LncRNAs are also associated with imprinting disorders, such as ubiquitin protein ligase E3A (UBE3A)-ATS in Angelman syndrome." N/A N/A N/A N/A Human N/A N/A 23562612 uc.115- heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 10 downregulated in HF hearts as compared with control hearts. N/A N/A N/A N/A Mouse N/A N/A 24205036 uc.184+ heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 19 downregulated in HF hearts as compared with control hearts. N/A N/A N/A N/A Mouse N/A N/A 24205036 UCA1 bladder cancer Expression Diagnostic marker oncogene chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24373479 UCA1 bladder cancer Expression "In adult human tissues, UCA1 gene was not expressed except in the heart and spleen. The expression level of UCA1 was increased in 8 common tumor tissues as compared with that in the corresponding normal tissues." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 20117985 UCA1 bladder cancer Expression "Overexpression of UCA1a(CUDR) significantly enhanced proliferation, migration and invasion of the bladder cancer cell line UM-UC-2." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 22576688 UCA1 bladder cancer Expression UCA1 was identified as a novel noncoding RNA gene dramatically up-regulated in TCC (bladder transitional cell carcinoma) and it is the most TCC-specific gene yet identified. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 16914571 UCA1 bladder cancer Expression "UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 18501714 UCA1 bladder cancer Expression "With a high level of sensitivity and specificity, UCA1 is a promising urinary marker for the diagnosis of bladder cancer." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 22490897 UCA1 bladder cancer Interaction Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 22289355 UCA1 bladder cancer Expression Theseguilty by association studies have found numerous bladder-cancer associated lncRNAs chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24006935 UCA1 bladder cancer Expression Upregulation of long non-coding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding protein α contributes to bladder cancer cell growth and reduced apoptosis. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24648007 UCA1 bladder cancer Regulation Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24495014 UCA1 oral squamous cell carcinoma Expression "Subsequently, they confirmed that the expression levels of HOTAIR, NEAT-1 and UCA3 in metastasized samples was prominent higher than the non-metastatic samples." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24817925 UCA1 pancreaticobiliary maljunction Expression Gene expression profiling reveals upregulated UCA1 and BMF in gallbladder epithelia of children with pancreaticobiliary maljunction. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 21593646 UCA1 squamous cell carcinoma Expression "Cancer up-regulated drug resistant (CUDR) gene, was found to be overexpressed in a doxorubicin-resistant subline of human squamous carcinoma A431 and A10A cells." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 17416635 UCA1 tongue squamous cell carcinoma Expression "Meaningfully, the expression levels of UCA1 lncRNA were dramatically higher in TSCC tissues than those in paired ANTs." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24817925 UCA1 cancer Regulation Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1). chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24457952 VL30 LTRs hepatocellular carcinoma Expression "Trim24 (Tif1) and Trim33 (Tif1) interact to form a co-repressor complex that suppresses murine hepatocellular carcinoma. Here we show that Trim24 and Trim33 cooperatively repress retinoic acid receptor-dependent activity of VL30-class endogenous retroviruses (ERVs) in liver. In Trim24-knockout hepatocytes, VL30 derepression leads to accumulation of reverse-transcribed VL30 cDNA in the cytoplasm that correlates with activation of the viral-defense interferon responses mimicking the preneoplastic inflammatory state seen in human liver following exogenous viral infection. Furthermore, upon derepression, VL30 long terminal repeats (LTRs) act as promoter and enhancer elements deregulating expression of neighboring genes and generating enhancer RNAs that are required for LTR enhancer activity in hepatocytes in vivo. " N/A N/A N/A N/A Mouse N/A N/A 23377542 WRAP53 cancer Expression "A natural antisense transcript of TP53, WRAP53, was strongly augmented by idarubicin and etoposide." N/A N/A N/A N/A Human N/A N/A 21441950 WRAP53 cancer N/A WRAP53 promotes cancer cell survival and is a potential target for cancer therapy. N/A N/A N/A N/A Human N/A N/A 21368886 WRAP53 dyskeratosis congenita Mutation Disruption of telomerase trafficking by WRAP53 mutation causes dyskeratosis congenita. N/A N/A N/A N/A Human N/A N/A 21205863 WT1-AS acute myeloid leukemia Epigenetics The incidence of WIT-1 methylation in primary refractory AML was significantly higher than that noted in chemosensitive AML. chr11 32435518 32458769 + Human WIT-1; WIT11; WT1AS; WT1-AS NR_120546 10340388 WT1-AS acute myeloid leukemia Interaction "In AML, there is often abnormal splicing of WT1-AS, which may play a role in the development of this malignancy." chr11 32435518 32458769 + Human WIT-1; WIT11; WT1AS; WT1-AS NR_120546 17940140 WT1-AS Wilms' tumor Epigenetics A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis. chr11 32435518 32458769 + Human WIT-1; WIT11; WT1AS; WT1-AS NR_120546 17210670 WT1-AS Wilms' tumor Interaction "WT1 is a gene that is mutated in Wilms' tumor (WT) and acute myeloid leukaemia (AML) and has an antisense transcript (WT1-AS), which was found to regulate WT1 protein levels." chr11 32435518 32458769 + Human WIT-1; WIT11; WT1AS; WT1-AS NR_120546 17940140 Wt1os ischaemia-reperfusion injury Expression Classification and validation of deregulated LncRNAs in ischemia/reperfusion-treated mouse livers. chr2 105076538 105126510 - Mouse 6030498F17; AI314831; Wt1-as NR_015462 24312245 XIST bladder cancer Regulation Putative diagnostic and prognostic marker chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 24373479 XIST breast cancer Mutation "The intratumoral and intertumoral variability in XIST RNA domain number in BRCA1 tumors correlates with chromosomal genetic abnormalities, including gains, losses, reduplications, and rearrangements of the X-chromosome." chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 17545591 XIST cancer Regulation Dysfunction of XIST may trigger the chromatin instability and promote caner development. chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 24757675 XIST cancer Regulation The lncRNA Xist was found to be a potent tumor suppressor of hematologic malignancies in vivo. chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 24829860 XIST cancer Expression "Recent studies have linked their mis-expression to diverse cancers (ANRIL: prostate cancer, XIST: female cancers, HOTAIR: breast cancer, KCNQ1OT2: colorectal cancer)." chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 23660942 XIST Klinefelter's syndrome Epigenetics "Severe XIST hypomethylation clearly distinguishes (SRY+) 46,XX-maleness from Klinefelter syndrome." chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 19812237 XIST Klinefelter's syndrome Expression "We demonstrated by quantitative RT-PCR an active XIST RNA expression in blood lymphocytes from Klinefelter patients, comparable to that observed in control females and over 30,000-fold greater than in control males." chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 18854511 XIST testicular cancer Expression XIST expression was common in seminomatous testicular germ cell tumors but not in nonseminomatous testicular germ cell tumors. chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 12629412 LINC00538 cancer Expression "Expression profiling revealed a general and regulated expression pattern of Yiya in major tissues, and more interestingly, identified elevated mRNA levels in different cancers." chr1 213924749 213926654 + Human PROX1UT; Yiya NR_046189 22258142 ZFAT-AS1 autoimmune disease Mutation "SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT (ZFAT-AS1), determine susceptibility to autoimmune thyroid disease." chr8 134598071 134600689 + Human NCRNA00070; SAS-ZFAT; ZFAT-AS; ZFATAS NR_002438 15294872 Zim3 heart failure Expression Quantitative-PCR identified the relative expression of 5 significantly upregulated and 5 downregulated LncRNAs from 10 HF mice. Five LncRNAs were upregulated and 13 downregulated in HF hearts as compared with control hearts. chr7 6955685 6976662 - Mouse 1700128I23Rik NR_036631 24205036 ZFAS1 breast cancer Expression SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer.ZFAS1 is highly expressed in the mammary gland and is down-regulated in breast tumors compared to normal tissue. ZFAS1 is a putative tumor suppressor gene. chr20 49278178 49289260 + Human C20orf199; HSUP1; HSUP2; NCRNA00275; ZNFX1-AS1 NR_036658 21460236 ZFAS1 breast cancer Locus SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer. ZFAS1 as a putative tumor suppressor gene. chr20 49278178 49289260 + Human C20orf199; HSUP1; HSUP2; NCRNA00275; ZNFX1-AS1 NR_036658 21460236 ZFAS1 ductal carcinoma Expression Human ZFAS1 levels are reduced in ductal carcinoma relative to normal breast tissue. chr20 49278178 49289260 + Human C20orf199; HSUP1; HSUP2; NCRNA00275; ZNFX1-AS1 NR_036658 21460236 PVT1 gastric cancer Expression Overexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistance chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 25956062 LINC01133 lung squamous cell carcinoma Expression LSCC patients with higher expression level of LINC01133 had shorter survival time. LINC01133 is upregulated in lung squamous cell cancer and predicts survival chr1 159961224 159979086 + Human N/A NR_038849 25908174 lnc-LCE5A-1 head and neck squamous cell carcinoma Expression "Ectopic expression of lnc-LCE5A-1 increased the expression of CDH-1 in HNSCC cells, while decreasing the expression of OCT-4, NANOG, and VIM." N/A N/A N/A N/A Human N/A N/A 25904139 FAM3D-AS1 head and neck squamous cell carcinoma Expression Overexpression of lnc-KCTD6-3 reduced the expression of NANOG chr3 58607080 58634440 + Human lnc-KCTD6-3 NR_134853 25904139 UCA1 gastric cancer Expression "UCA1 expression was remarkably increased in gastric cancer tissues and cell lines compared with that in the normal control; high UCA1 expression correlated with worse differentiation, tumor size, invasion depth and TNM stage in gastric cancer; increased UCA1 expression contributed to poor overall survival and disease-free survival of patients." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 25903045 HOTAIR oral squamous cell carcinoma Regulation Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25901533 AS Uchl1 Parkinson's disease Expression Uch1 RNA levels are strongly down-regulated in neurochemical models of PD in vitro and in vivo N/A N/A N/A N/A Human N/A N/A 25883552 H19 breast cancer Regulation H19 lncRNA mediates 17beta-estradiol-induced cell proliferation in MCF-7 breast cancer cells; H19 lncRNA was much higher in estrogen receptor (ER)-positive MCF-7 breast cancer cells than in ER-negative MDA-MB-231 cells chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 25846769 SPRY4-IT1 gastric cancer Expression SPRY4-IT1 expression was elevated in GC tissues and cell lines chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 25835973 LOC728228 lung cancer Expression LOC728228 was upregulated relative to its expression in control untransformed16HBE (16HBE-N) cells. N/A N/A N/A N/A Human N/A N/A 25820656 MALAT1 glioblastoma Expression Extensive microRNA-mediated crosstalk between lncRNAs and mRNAs in mouse WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25772239 H19 coronary artery disease Expression Re-expression of H19 has been observed in patients with atherosclerosis. Common polymorphisms of H19 are associated with the risk and severity of CAD in a Chinese population. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 25772106 TUSC7 gastric cancer Regulation TUSC7 was downregulated in GC samples and was an independent prognostic indicator of disease-free survival (DFS) and disease-specific survival (DSS) in GC patients; TUSC7 was a direct transcriptional target of p53 via interaction of p53 with the putative p53-response element in the upstream region of TUSC7 chr3 116709788 116717040 + Human LINC00902; LSAMP-AS1; LSAMP-AS3; LSAMPAS3; NCRNA00295 NR_015391 25765901 HIF1A-AS1 cardiovascular disease Regulation Clopidogrel reduces apoptosis and promotes proliferation of human vascular endothelial cells induced by palmitic acid via suppression of the long non-coding RNA HIF1A-AS1 in vitro. chr14 61681041 61695823 - Human 5'aHIF-1A; 5'aHIF1alpha NR_047116 25761653 UCA1 hepatocellular carcinoma Regulation Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 25760077 lncRNA-ATB colorectal cancer Expression "High lncRNA-ATB expression was significantly associated with greater tumor size, depth of tumor invasion, lymphatic invasion, vascular invasion, and lymph node metastasis. Additionally, levels of lncRNA-ATB expression were significantly higher in patients with hematogenous metastases." N/A N/A N/A N/A Human N/A N/A 25750289 Arid2-IR renal inflammation Regulation Arid2-IR is a novel lncRNA that functions to promote NF-KB-dependent renal inflammation. Overexpression of Arid2-IR promoted interleukin-1-induced NF-κB signaling and inflammatory cytokine expression without alteration of TGF-beta1-induced fibrotic response. N/A N/A N/A N/A Human N/A N/A 25743111 TINCR gastric cancer Regulation "TINCR is strongly upregulated in human gastric carcinoma (GC), where it was found to contribute to oncogenesis and cancer progression. TINCR overexpression is induced by nuclear transcription factor SP1. TINCR contributes to the oncogenic potential of GC and may constitute a potential therapeutic target in this disease." chr19 5558167 5568034 - Human LINC00036; NCRNA00036; PLAC2; onco-lncRNA-16 NR_027064 25728677 NRON AIDS Regulation The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins. Its expression was significantly altered following HIV-1 infection. Its levels were reduced by the early viral accessory protein Nef and increased by the late protein Vpu. chr9 126407775 126410504 - Human NCRNA00194 NR_045006 25728138 MALAT2 gastric cancer Expression MALAT2-activated long noncoding RNA indicates a biomarker of poor prognosis in gastric cancer. MALAT2 was frequently over-expressed in cancer tissues and this over-expression was found to significantly correlate with lymph node metastasis and tumor stage. N/A N/A N/A N/A Human N/A N/A 25721209 DRAIC cancer Expression "The lncRNA DRAIC/PCAT29 Locus Constitutes a Tumor-Suppressive Nexus. Prostate cancers persisting in patients after androgen deprivation therapy (ADT) select for decreased DRAIC expression, and higher levels of DRAIC in prostate cancer are associated with longer disease-free survival (DFS). DRAIC expression predicts good prognosis in a wide range of malignancies, including bladder cancer, low-grade gliomas, lung adenocarcinoma, stomach adenocarcinoma, renal clear cell carcinoma, hepatocellular carcinoma, skin melanoma, and stomach adenocarcinoma." chr15 69561720 69571440 + Human N/A NR_026979 25700553 DANCR postmenopausal osteoporosis Regulation DANCR promoted the expression of IL6 and TNF-alpha at both mRNA level and protein level in MNCs. DANCR level was correlated with IL6 and TNF-alpha in postmenopausal women with low BMD chr4 52712454 52714138 + Human AGU2; ANCR; KIAA0114; SNHG13; lncRNA-ANCR NR_024031 25660720 MRAK052686 nonalcoholic fatty liver disease Expression "Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles. MRAK052686, was found strongly correlated with the antioxidant factor Nrf2, and both genes were down-regulated by the steatotic liver. The reduced expression of MRAK052686 and Nrf2 was completely reversed by BBR treatment, suggesting a new mechanism accounting for the therapeutic effect of BBR." N/A N/A N/A N/A Human N/A N/A 25623289 Abhd11os neurodegenerative diseases Expression "The striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo. Abhd11os overexpression produces neuroprotection against an N-terminal fragment of mutant huntingtin, whereas Abhd11os knockdown is protoxic." N/A N/A N/A N/A Human N/A N/A 25619660 HOTAIR gastric cancer Regulation HOTAIR Long Noncoding RNA Promotes Gastric Cancer Metastasis through Suppression of Poly r(C)-Binding Protein (PCBP) 1. Our findings provide mechanistic evidence for HOTAIR overexpression and PCBP1 downregulation and the ensuing malignant phenotype in both cultured and xenograft gastric cancer cells. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25612617 MALAT1 renal cell carcinoma Regulation "Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205. MALAT1 expression was higher in human RCC tissues, where it was associated with reduced patient survival." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25600645 CTBP1-AS polycystic ovary syndrome Regulation C-Terminal binding protein 1 antisense (CTBP1-AS) was a novel long noncoding RNA (lncRNA) to regulate AR activity. Expression level of CTBP1-AS in peripheral blood leukocytes was significantly higher in women with PCOS than that in controls after adjustment for age and body mass index (BMI). chr4 1210120 1218591 + Human PCAT10 NR_104331 25552498 LSINCT5 gastric cancer Expression "The expression of LSINCT5 is significantly upregulated in gastrointestinal cancer tissues and cell lines relative to their normal counterparts. Increased LSINCT5 expression was correlated with a larger tumor size, deeper tumor depth, and advanced clinical stage. Gastric cancer (GC) and colorectal cancer (CRC) patients with higher LSINCT5 expression levels have worse disease-free survival (DFS) and disease-specific survival (DSS) rates." chr5 2712591 2715237 - Human N/A NR_145480 25526476 NBAT1 neuroblastoma Regulation The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation. Loss of NBAT-1 increases cellular proliferation and invasion. chr6 22134602 22147193 - Human CASC14; NBAT-1 NR_034143 25517750 PCGEM1 prostate cancer Expression "PCGEM1 overexpression is highly associated with prostate tumors. CGEM1 tumorigenic potential has been recently shown to be in part due to its ability to activate androgen receptor (AR). Here, we report a novel function of PCGEM1 that provides growth advantages for cancer cells by regulating tumor metabolism via c-Myc activation. PCGEM1 promotes glucose uptake for aerobic glycolysis, coupling with the pentose phosphate shunt to facilitate biosynthesis of nucleotide and lipid, and generates NADPH for redox homeostasis." chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 25512540 SCHLAP1 prostate cancer Expression "SChLAP1 expression increases with prostate cancer progression,and high SChLAP1 expression by ISH is associated with poor outcome after radical prostatectomy in patients with clinically localized prostate cancer by both univariate and multivariate Cox regression analyses." chr2 180692104 180916939 + Human SCHLAP1 ENST00000629145 25499224 UBE3A-ATS Angelman syndrome Expression ASO treatment achieved specific reduction of Ube3a-ATS and sustained unsilencing of paternal Ube3a in neurons in vitro and in vivo. Partial restoration of UBE3A protein in an Angelman syndrome mouse model ameliorated some cognitive deficits associated with the disease. N/A N/A N/A N/A Human N/A N/A 25470045 SCHLAP1 prostate cancer Expression The long non-coding RNA SChLAP1 was identified as the highest-ranked overexpressed gene in cancers with metastatic progression. chr2 180692104 180916939 + Human SCHLAP1 ENST00000629145 25456366 PCA3 prostate cancer Expression "By PCR-based cloning and sequencing in paired peripheral blood leukocytes and prostate tissues,5 PCA3 TAAA STR polymorphisms and 8 genotypes were found in both peripheral blood leukocytes and prostate tissues, the carriers with more TAAA repeats were associated with increased risk for PCa than individuals having less TAAA repeats" chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 25445501 LINC01158 glioma Expression "By using real-time PCR and gain-/loss-of-function studies,the authors revealed that linc-POU3F3 levels were extraordinarily associated with the tumor WHO grade.In related biochemical assays, overexpression of linc-POU3F3 promotes cell viability and proliferation in glioma cells, whereas knockdown of linc-POU3F3 showed the opposite effect. As expected, they also found that linc-POU3F3 expression was negatively correlated with the mRNA level of POU3F3." chr2 104805425 104853183 - Human PANTR1; linc-Brn1a; linc-POU3F3 NR_037883 25445282 BCAR4 breast cancer Regulation "BCAR4 binding of SNIP1 and PNUTS in response to CCL21 releases the SNIP1's inhibition of p300-dependent histone acetylation, which in turn enables the BCAR4-recruited PNUTS to bind H3K18ac and relieve inhibition of RNA Pol II via activation of the PP1 phosphatase." chr16 11819830 11828832 - Human N/A NR_024050 25416949 MALAT1 multiple myeloma Expression "MALAT1 was overexpressed in the newly diagnosed patients compared with post-treatment patients and healthy individuals. The expression of MALAT1 strongly correlated with disease status, and the magnitude of change in MALAT1 post-treatment had prognostic relevance. The patients with early progression had a significantly smaller change in MALAT1 after treatment." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25369863 NEAT1 infertility Expression "Neat1 knockout (KO) mice stochastically fail to become pregnant despite normal ovulation. Unilateral transplantation of wild-type ovaries or the administration of progesterone partially rescued the phenotype, suggesting that corpus luteum dysfunction and concomitant low progesterone were the primary causes of the decreased fertility. In contrast to the faint expression observed in most of the adult tissues, Neat1 was highly expressed in the corpus luteum, and the formation of luteal tissue was severely impaired in nearly half of the Neat1 KO mice" chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 25359727 Malat1 diabetes mellitus Expression "MALAT1 expression is significantly upregulated in the retinas of STZ-induced diabetic rats and db/db mice. MALAT1 knockdown could obviously ameliorate DR in vivo, as shown by pericyte loss, capillary degeneration, microvascular leakage, and retinal inflammation. Moreover, MALAT1 knockdown could regulate retinal endothelial cell proliferation, migration, and tube formation in vitro. The crosstalk between MALAT1 and p38 MAPK signaling pathway is involved in the regulation of endothelial cell function." chr19 5795690 5802671 - Mouse 2210401K01Rik; 9430072K23Rik; AI647968; Neat2 NR_002847 25356875 ENST00000480739 pancreatic ductal adenocarcinoma Expression the ENST00000480739 expression level was remarkably chr12 57674665 57675250 + Human RPL13AP23 ENST00000480739 25314054 lnc-SCA7 spinocerebellar ataxia Mutation "STAGA is required for the transcription initiation of miR-124, which in turn mediates the post-transcriptional cross-talk between lnc-SCA7, a conserved long noncoding RNA,and ATXN7 mRNA. In SCA7, mutations in ATXN7 disrupt these regulatory interactions and result in a neuron-specific increase in ATXN7 expression. Strikingly, in mice this increase is most prominent in the SCA7 disease-relevant tissues, namely the retina and cerebellum." N/A N/A N/A N/A Human N/A N/A 25306109 CERNA2 epithelial ovarian cancer Regulation "EOC-specific lncRNA-HOST2, which acts as a miRNA sponge, sequesters let-7b to maintain the expression of oncogenes and further maintains EOC biological functions." chr10 84167228 84172076 - Human HOST2; lncRNA-HOST2 NR_134505 25292198 GAPLINC gastric cancer Expression "GAPLINC is a 924-bp-long lncRNA that is highly expressed in gastric cancer tissues. GAPLINC suppression and with gene expression profiling in gastric cancer cells revealed alterations in cell migration pathways, with CD44 expression the most highly correlated. Manipulating GAPLINC" chr18 3466250 3478978 + Human LINC01540 NR_110428 25277524 RP5-833A20.1 atherosclerosis Expression "Using microarray analysis, the authors found that long noncoding RNA RP5-833A20.1 expression was upregulated, whereas nuclear factor IA (NFIA) expression was downregulated in human acute monocytic leukemia macrophage-derived foam cells. Moreover, they showed that long noncoding RNA RP5-833A20.1 maydecreases NFIA expression by inducing hsa-miR-382-5p expression in vitro. " chr1 61248945 61253510 - Human NFIA-AS1 ENST00000630993 25265644 LINC-ROR breast cancer Expression LincRNA-RoR is upregulated in TNBC and in metastatic disease and knockdown restores miR-145 expression.The lincRNA-RoR/miR-145/ARF6 pathway is critical to TNBC metastasis and could serve as biomarkers or therapeutic targets for improving survival. chr18 57054571 57072119 - Human ROR; lincRNA-RoR NR_048536 25253741 AC006050.3 lung squamous cell carcinoma Expression "The expression of lncRNA AC006050.3-003 was significantly lower in PR samples compared to the PD samples in another 60 lung squamous cell carcinoma patients. Receiver operating characteristic curve analysis revealed that lncRNA AC006050.3-003 was a valuable biomarker for differentiating PR patients from PD patients with an area under the curve of 0.887 (95% confidence interval 0.779, 0.954)." N/A N/A N/A N/A Human N/A N/A 25250788 LOC285194 esophageal squamous cell carcinoma Expression "LOC285194 expression was significantly down-regulated in ESCC tumor tissues when compared with the adjacent normal tissues. Low expression of LOC285194 was associated with larger tumor size, advanced TNM stage, more lymph node metastases and distant metastases." N/A N/A N/A N/A Human N/A N/A 25169763 AB074278 bladder cancer Expression "We implicate upregulation of AB074278 in apoptosis avoidance and the maintenance of a proproliferative state in cancer through a potential interaction with EMP1, a tumor suppressor and a negative regulator of cell proliferation." N/A N/A N/A N/A Human N/A N/A 25165097 XIST membranous nephropathy Expression "Urinary Xist is significantly elevated in urine samples from patients with different types of glomerular nephritis, including MN, compared to normal counterparts." chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 25157805 CDKN2B-AS1 endometriosis Mutation Rs10965235 SNP in the CDKN2B-AS gene was significantly associated with endometriosis in this Korean population. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 25154675 WNT4 endometriosis Mutation Rs10965235 SNP in the rs16826658 SNP near the WNT4 gene was significantly associated with endometriosis in this Korean population. N/A N/A N/A N/A Human N/A N/A 25154675 HOTAIR renal carcinoma Regulation Suppressed expression of long non-coding RNA HOTAIR inhibits proliferation and tumourigenicity of renal carcinoma cells. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25149152 UCA1 urinary bladder Expression UCA1 expression was found in T24 cell line and also found to be significantly higher in the cancer group as compared to the controls chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 25123267 HA117 Hirschsprung's disease Expression HA117 expression in stenotic segment was higher compared to proximal anastomosis and dilated segment (p < 0.05); HA117 may be a factor exerting an anti-differentiation or anti-maturation role in the genesis of HSCR. N/A N/A N/A N/A Human N/A N/A 25120773 HOTAIR laryngeal squamous cell carcinoma Expression The expression of exosomal miR-21 and HOTAIR was significantly higher in patients with laryngeal squamous cell carcinomaLSCC than those with vocal cord polyps; The patients with lymph node metastasis had higher serum exosomal miR-21 and HOTAIR expressions than those without. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25099764 TARID cancer Regulation Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A. chr6 133502252 133889006 - Human EYA4-AS1 NR_109982 25087872 PVT1 hepatocellular carcinoma Regulation Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell-like property of hepatocellular carcinoma cells by stabilizing NOP2 chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 25043274 PVT1 cancer Expression "A single supernumerary segment encompassing all four genes(Myc gene or the region encompassing Pvt1, Ccdc26 and Gsdmc ) successfully promotes cancer; PVT1 RNA and MYC protein expression correlated in primary human tumours, and copy number of PVT1 was co-increased in more than 98% of MYC-copy-increase cancers." chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 25043044 HIF1A-AS1 acute myocardial infarction Expression Level of hypoxia inducible factor 1A antisense RNA 2 was higher in patients with MI than in healthy volunteers (P<0.01) chr14 61681041 61695823 - Human 5'aHIF-1A; 5'aHIF1alpha NR_047116 25035150 CDKN2B-AS1 acute myocardial infarction Expression Level of ANRIL was lower in patients with MI (P=0.003)Patients with ST-segment-elevation MI had lower level of ANRIL (P<0.001)when compared with patients with non-ST-segment-elevation MI. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 25035150 KCNQ1OT1 acute myocardial infarction Expression Level of KCNQ1OT1 was higher in patients with MI than in healthy volunteers (P<0.01);Patients with ST-segment-elevation MI had lower levels of KCNQ1OT1 (P<0.001)when compared with patients with non-ST-segment-elevation chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 25035150 MALAT1 acute myocardial infarction Expression Level of metastasis-associated lung adenocarcinoma transcript 1 was higher in patients with MI than in healthy volunteers (P<0.01); Patients with ST-segment-elevation MI had lower levels of metastasis-associated lung adenocarcinoma transcript 1 (P=0.005) when compared with patients with non-ST-segment-elevation chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25035150 MIAT acute myocardial infarction Expression Patients with ST-segment-elevation MI had lower levels of myocardial infarction-associated transcript (P<0.001)when compared with patients with non-ST-segment-elevation chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 25035150 XLOC_004562 H.pylori-related diseases Expression "Using qPCR,the five lncRNAs were found differentially expressed in H. pylori-infected gastric epithelial cells" N/A N/A N/A N/A Human N/A N/A 25420666 XLOC_005912 H.pylori-related diseases Expression "Using qPCR,the five lncRNAs were found differentially expressed in H. pylori-infected gastric epithelial cells" N/A N/A N/A N/A Human N/A N/A 25420666 XLOC_000620 H.pylori-related diseases Expression "Using qPCR,the five lncRNAs were found differentially expressed in H. pylori-infected gastric epithelial cells" N/A N/A N/A N/A Human N/A N/A 25420666 XLOC_004122 H.pylori-related diseases Expression "Using qPCR,the five lncRNAs were found differentially expressed in H. pylori-infected gastric epithelial cells" N/A N/A N/A N/A Human N/A N/A 25420666 XLOC_014388 H.pylori-related diseases Expression "Using qPCR,the five lncRNAs were found differentially expressed in H. pylori-infected gastric epithelial cells" N/A N/A N/A N/A Human N/A N/A 25420666 Asb3 cardiovascular and renal disease Expression "The protein expression status of 4 target genes, Asb3, Chac2, Pex11b, and Sp5, were differentially expressed between the relevant strain comparisons, thereby suggesting that the differentially expressed lncRNAs associated with these genes are candidate genetic determinants of blood pressure" N/A N/A N/A N/A Human N/A N/A 25385761 Chac2 cardiovascular and renal disease Expression "The protein expression status of 4 target genes, Asb3, Chac2, Pex11b, and Sp5, were differentially expressed between the relevant strain comparisons, thereby suggesting that the differentially expressed lncRNAs associated with these genes are candidate genetic determinants of blood pressure" N/A N/A N/A N/A Human N/A N/A 25385761 Pex11b cardiovascular and renal disease Expression "The protein expression status of 4 target genes, Asb3, Chac2, Pex11b, and Sp5, were differentially expressed between the relevant strain comparisons, thereby suggesting that the differentially expressed lncRNAs associated with these genes are candidate genetic determinants of blood pressure" N/A N/A N/A N/A Human N/A N/A 25385761 Sp5 cardiovascular and renal disease Expression "The protein expression status of 4 target genes, Asb3, Chac2, Pex11b, and Sp5, were differentially expressed between the relevant strain comparisons, thereby suggesting that the differentially expressed lncRNAs associated with these genes are candidate genetic determinants of blood pressure" N/A N/A N/A N/A Human N/A N/A 25385761 GSEC colon cancer Regulation GSEC plays an important role in colon cancer cell migration by inhibiting the function of DHX36 via its G-quadruplex structure. chr11 126341716 126355587 - Human DCPS-AS1; ST3GAL4-AS1 NR_033839 27797375 AFAP1-AS1 lung adenocarcinoma Regulation Knockdown of the up-regulated lncRNA AFAP1-AS1 impaired LUAD cell proliferation. chr4 7754090 7778928 + Human AFAP1-AS; AFAP1AS NR_026892 27797003 LINC00511 lung adenocarcinoma Regulation Knockdown of the up-regulated lncRNA LINC00511 impaired LUAD cell proliferation chr17 72598041 72640472 - Human LCAL5; onco-lncRNA-12 NR_033876 27797003 PVT1 lung squamous cell carcinoma Regulation Knockdown of PVT1 inhibited LUSC cell growth. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 27797003 H19 diabetic cardiomyopathy Regulation LncRNA H19/miR-675 axis regulates cardiomyocyte apoptosis by targeting VDAC1 in diabetic cardiomyopathy. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27796346 NONHSAT076747 papillary thyroid carcinoma N/A The lncRNAs NONHSAT076747 was associated with lymph node metastasis. N/A N/A N/A N/A Human N/A N/A 27758138 NONHSAT122730 papillary thyroid carcinoma N/A The lncRNAs NONHSAT122730 was associated with lymph node metastasis N/A N/A N/A N/A Human N/A N/A 27758138 NONHSAG051968 papillary thyroid carcinoma Expression NONHSAG051968 expression was egatively correlated with tumor size N/A N/A N/A N/A Human N/A N/A 27758138 PVT1 gastric cancer Regulation PVT1 which facilitates gastric cancer growth and invasion is an important epigenetic regulator with a critical role in human tumors. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 27756785 PVT1 prostate cancer Expression LncRNA PVT1 was overexpressed in prostate cancer and played an oncogenic role in the progression of prostate cancer. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 27794184 MEG3 bladder cancer Expression Low expression of MEG3 was associated with poor recurrence-free survival chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 27793008 HOXA11-AS cervical cancer Regulation The long noncoding RNA HOXA11 antisense induces tumor progression and stemness maintenance in cervical cancer. chr7 27185408 27189293 + Human HOXA-AS51; HOXA11AS; HOXA11S; NCRNA00076; HOXA11-AS NR_002795 27792998 NBR2 cancer N/A NBR2 deficiency sensitizes cancer cells to phenformin-induced cell death. chr17 43125583 43145113 + Human NCRNA00192 NR_003108 27792451 TUG1 breast cancer Regulation LncRNA TUG1 promotes breast cancer cell proliferation via inhibiting miR-9 chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27791993 ASBEL colorectal cancer Expression ASBEL-TCF3-mediated down-regulation of ATF3 expression is required for the proliferation and tumorigenicity of colon tumor cells. N/A N/A N/A N/A Human N/A N/A 27791078 HIT non-small cell lung cancer Regulation "LncRNA-HIT promotes cell migration, invasion, tumor growth, and metastasis." N/A N/A N/A N/A Human N/A N/A 27790864 FOXP4-AS1 colorectal cancer Expression FOXP4-AS1 was up-regulated in CRC tissues and cell lines and that its overexpression positively correlated with advanced pathological stages and larger tumour size. chr6 41523895 41548621 - Human N/A NR_126416 27790757 HOTAIRM1 leukemia Expression HOTAIRM1 is a promising lncRNA biomarker in leukemia and solid tumors. chr7 27096094 27100258 + Human HOXA-AS1; HOXA1-AS1; NCRNA00179 NR_038367 27789700 H19 calcific aortic valve disease Regulation H19 induces a strong osteogenic phenotype by altering the NOTCH1 pathway and H19 silenced NOTCH1 by preventing the recruitment of p53 to its promoter. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27789555 H19 colorectal cancer Regulation "H19 silencing blocked G1-S transition, reduced cell proliferation, and inhibited cell migration." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27789274 SNHG18 glioma Expression The expression of SNHG18 was remarkably upregulated in clinical glioma tissues compared with normal brain tissues. chr5 9546200 9550298 + Human N/A NR_045196 27788958 91H breast cancer Regulation 91H may play essential role in breast cancer development. N/A N/A N/A N/A Human N/A N/A 27780718 AFAP1-AS1 esophageal squamous cell carcinoma Expression AFAP1-AS1 is upregulated and promotes esophageal squamous cell carcinoma cell proliferation and inhibits cell apoptosis. chr4 7754090 7778928 + Human AFAP1-AS; AFAP1AS NR_026892 27577754 PCAT14 prostate cancer Expression "Low PCAT-14 expression increased migration while overexpressing PCAT-14 reduced cellular growth, migration, and invasion." chr22 23538102 23547306 + Human N/A NR_109832 27460352 HOTAIR cervical cancer Expression "Exosomal lncRNA HOTAIR may have great potential to be used for the early detection and diagnosis of cervical cancer, and serve as convenient and noninvasive biomarkers." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27184657 MALAT1 cervical cancer Expression "Exosomal lncRNA MALAT1 may have great potential to be used for the early detection and diagnosis of cervical cancer, and serve as convenient and noninvasive biomarkers." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27184657 MEG3 cervical cancer Expression "Exosomal lncRNA MEG3 may have great potential to be used for the early detection and diagnosis of cervical cancer, and serve as convenient and noninvasive biomarkers." chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 27184657 H19 gastric cancer Expression Its role is a potential non-invasive diagnostic biomarker in gastric cancer and as a novel tool in gastric cancer management chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27184562 LOC100287225 colorectal cancer N/A The misregulation of DCC and LOC100287225 is concurrent in colorectal cancer. N/A N/A N/A N/A Human N/A N/A 26429648 AK098081 colorectal cancer Expression High expression of AK098081 indicated poor CRC differentiation. N/A N/A N/A N/A Human N/A N/A 27788162 BC040303 colorectal cancer Expression Low expression of BC040303 indicated poor CRC differentiation. N/A N/A N/A N/A Human N/A N/A 27788162 BC037331 colorectal cancer Expression Low expression of BC037331 indicated poor CRC differentiation. N/A N/A N/A N/A Human N/A N/A 27788162 CR749831 colorectal cancer Expression Low expression of CR749831 indicated poor CRC differentiation. N/A N/A N/A N/A Human N/A N/A 27788162 RAMP2-AS1 glioblastoma Regulation RAMP2-AS1 might play a tumor suppressive role in GBM through an indirect inhibition of NOTCH3. chr17 42753914 42761257 - Human N/A NR_024462 27784795 linc-cdh4-2 hepatocellular carcinoma Regulation Long non-coding RNA linc-cdh4-2 inhibits the migration and invasion of HCC cells by targeting R-cadherin pathway. N/A N/A N/A N/A Human N/A N/A 27765630 Uph right ventricular hypoplasia Locus Hand2-associated long non-coding RNA upperhand (Uph) is required to maintain the super-enhancer signature and elongation of RNA polymerase II through the Hand2 enhancer locus. chr8 57304414 57320859 N/A Mouse N/A NR_110474 27783597 HULC hepatocellular carcinoma Regulation "HULC promotes tumorigenesis by regulating multiple pathways, such as down-regulation of EEF1E1, promotion of abnormal lipid metabolism, and up-regulation of sphingosine kinase 1." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 27781386 HULC gastric cancer Regulation "HULC promotes tumorigenesis by regulating multiple pathways, such as down-regulation of EEF1E1, promotion of abnormal lipid metabolism, and up-regulation of sphingosine kinase 1." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 27781386 HULC pancreatic cancer Regulation "HULC promotes tumorigenesis by regulating multiple pathways, such as down-regulation of EEF1E1, promotion of abnormal lipid metabolism, and up-regulation of sphingosine kinase 1." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 27781386 HULC osteosarcoma Regulation "HULC promotes tumorigenesis by regulating multiple pathways, such as down-regulation of EEF1E1, promotion of abnormal lipid metabolism, and up-regulation of sphingosine kinase 1." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 27781386 HULC colorectal cancer Regulation "HULC promotes tumorigenesis by regulating multiple pathways, such as down-regulation of EEF1E1, promotion of abnormal lipid metabolism, and up-regulation of sphingosine kinase 1." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 27781386 U90926 obesity Expression Overexpression lnc-U90926 attenuated 3T3-L1 adipocyte differentiation chr5 92209895 92215408 - Mouse N/A NR_033483 27780975 UCA1 breast cancer Expression UCA1 was upregulated by SATB1 depletion and SATB1 is highly expressed in aggressive breast cancer cells and promotes growth and metastasis by reprograming gene expression. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27697109 LINC-ROR gallbladder cancer Regulation LncRNA-ROR plays an important role in the development of gallbladder cancer and mediates the EMT in gallbladder cancer. chr18 57054571 57072119 - Human ROR; lincRNA-RoR NR_048536 27449039 numb uveal melanoma Regulation LncRNA-numb is a newly proposed tumor suppressor that is involved in HIC1-induced phenotypes. N/A N/A N/A N/A Human N/A N/A 27449031 HOTAIRM1 colorectal cancer Expression HOTAIRM1 as a potential biomarker for diagnosis of colorectal cancer functions the role in the tumour suppressor. chr7 27096094 27100258 + Human HOXA-AS1; HOXA1-AS1; NCRNA00179 NR_038367 27307307 MALAT1 breast cancer Regulation Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27250026 NEAT1 nasopharyngeal carcinoma Regulation The long non-coding RNA NEAT1 regulates epithelial to mesenchymal transition and radioresistance in through miR-204/ZEB1 axis in nasopharyngeal carcinoma. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27020592 GAS5 ovarian cancer Expression "Decreased expression of long non-coding RNA GAS5 promotes cell proliferation, migration and invasion, and indicates a poor prognosis in ovarian cancer." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 27779700 RP5-833A20.1 glioma Regulation The mechanisms by which RP5-833A20.1 regulates the expression of NFIA in glioma were investigated. chr1 61248945 61253510 - Human NFIA-AS1 ENST00000630993 27779670 MEG3 esophageal squamous cell carcinoma Expression "Ectopic expression of MEG3 in ESCC cells inhibited cell proliferation, promoted apoptosis, and suppressed metastasis." chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 27778235 MALAT1 non-small cell lung cancer Regulation "MALAT1 is thought to regulate tumor cell viability, invasiveness and migration " chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27777857 MALAT1 hepatocellular carcinoma Regulation "MALAT1 is thought to regulate tumor cell viability, invasiveness and migration " chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27777857 MALAT1 gastric cancer Regulation "MALAT1 is thought to regulate tumor cell viability, invasiveness and migration " chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27777857 MALAT1 pancreatic cancer Regulation "MALAT1 is thought to regulate tumor cell viability, invasiveness and migration" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27777857 MALAT1 colorectal cancer Regulation "MALAT1 is thought to regulate tumor cell viability, invasiveness and migration" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27777857 MALAT1 renal clear cell carcinoma Regulation "MALAT1 is thought to regulate tumor cell viability, invasiveness and migration " chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27777857 MALAT1 esophageal cancer Regulation "MALAT1 is thought to regulate tumor cell viability, invasiveness and migration " chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27777857 MALAT1 gallbladder cancer Regulation "MALAT1 is thought to regulate tumor cell viability, invasiveness and migration " chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27777857 MALAT1 bladder cancer Regulation "MALAT1 is thought to regulate tumor cell viability, invasiveness and migration " chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27777857 MALAT1 osteosarcoma Regulation "MALAT1 is thought to regulate tumor cell viability, invasiveness and migration " chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27777857 MALAT1 breast cancer Regulation "MALAT1 is thought to regulate tumor cell viability, invasiveness and migration " chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27777857 DBCCR1 bladder cancer Regulation Long non-coding RNA DBCCR1-003 regulate the expression of DBCCR1 via DNMT1 in bladder cancer. N/A N/A N/A N/A Human N/A N/A 27777512 CRNDE chronic lymphocytic leukemia Expression The novel lncRNA CRNDE was validated in an independent CLL sample cohort. chr16 54845189 54929189 - Human CRNDE ENST00000613942 27777635 AC012065.7 chronic lymphocytic leukemia Expression The novel lncRNA AC012065.7 was validated in an independent CLL sample cohort. N/A N/A N/A N/A Human N/A N/A 27777635 JPX hepatocellular carcinoma Expression JPX expression levels were independent prognostic factors for HCC overall survival rates. chrX 73944324 74070384 + Human DCBALD06; ENOX; LINC00183; NCRNA00183 NR_024582 27776968 XIST hepatocellular carcinoma Expression XIST expression levels were independent prognostic factors for HCC overall survival rates. chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 27776968 ZEB2-AS1 hepatocellular carcinoma Regulation Downregulation of ZEB2-AS1 decreased tumor growth and metastasis in hepatocellular carcinoma chr2 144519614 144520899 + Human ZEB2-AS; ZEB2AS; ZEB2NAT NR_040248 27748842 UCA1 esophageal cancer Regulation LncRNA-UCA1 enhances cell proliferation through functioning as a ceRNA of Sox4 in esophageal cancer. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27667646 SNHG7 lung cancer Regulation "LncRNA-SNHG7 promotes the proliferation, migration and invasion and inhibits apoptosis of lung cancer cells by enhancing the FAIM2 expression." chr9 136724594 136728184 - Human NCRNA00061 NR_024542 27666964 MEG3 vulvar squamous cell carcinoma Expression LncRNAs (MEG3 and MALAT1) were also identified as potential biomarkers as they also correlated with VSCC carcinogenesis. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 27633334 MALAT1 vulvar squamous cell carcinoma Expression LncRNAs (MEG3 and MALAT1) were also identified as potential biomarkers as they also correlated with VSCC carcinogenesis. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27633334 PVT1 cervical cancer Expression Long noncoding RNA PVT1 Is a novel serum biomarker for detection of cervical cancer. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 27775803 HULC cervical cancer Expression "The expression of HULC was upregulated in cervical cancer, and associated with overall survival, indicating that HULC may serve as a predictive biomarker for the prognosis of cervical cancer." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 27775802 CRNDE glioma Expression lncRNA CRNDE was associated with tumor progression and could be an independent prognostic factor for glioma patients. chr16 54845189 54929189 - Human CRNDE ENST00000613942 27775801 AB073614 glioma Regulation Knockdown of long noncoding RNA AB073614 inhibits glioma cell proliferation and migration via affecting epithelial-mesenchymal transition. N/A N/A N/A N/A Human N/A N/A 27775800 NEAT1 renal syndrome Expression The reduced NEAT1 level is correlated with the epidemic of HFRS chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27774948 RP1130-1 hepatocellular carcinoma Expression "The expression of LINC RP1130-1 was associated with clinical stage, the number of tumors, portal vein tumor thrombus (PVTT), and microvascular invasion (MVI)." N/A N/A N/A N/A Human N/A N/A 27773892 H19 glioma Regulation The lncRNA H19 interacts with miR-140 to modulate glioma growth by targeting iASPP. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27693036 MEG3 stroke Regulation Long noncoding RNA MEG3 activation of p53 mediates ischemic neuronal death in stroke. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 27651151 LINC00161 osteosarcoma Regulation Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis. chr21 28539318 28540355 + Human C21orf100; NCRNA00161 NR_026553 27609068 H19 lung cancer Regulation H19 lncRNA regulates the process of NSCLC metastasis. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27607135 Unigene56159 hepatocellular carcinoma Regulation Long non-coding RNA Unigene56159 promotes epithelial-mesenchymal transition by acting as a ceRNA of miR-140-5p in hepatocellular carcinoma cells. N/A N/A N/A N/A Human N/A N/A 27597739 UCA1 pancreatic cancer Regulation Long non-coding RNA UCA1 promotes the tumorigenesis in pancreatic cancer. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27562722 HCG11 prostate cancer Expression Downregulation of long non-coding RNA HCG11 predicts a poor prognosis in prostate cancer. chr6 26521706 26527393 + Human CTA-14H9.3; bK14H9.3 NR_026790 27522256 MEG3 thrombocytopenic purpura Regulation Long non-coding RNA MEG3 inhibits microRNA-125a-5p expression and induces immune imbalance of Treg/Th17 in immune thrombocytopenic purpura. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 27522004 CCDC26 pancreatic cancer Expression Long noncoding RNA CCDC26 as a potential predictor biomarker contributes to tumorigenesis in pancreatic cancer chr8 129351694 129680239 - Human RAM NR_130917 27470572 MALAT1 Parkinson's disease Regulation β-Asarone functions as a neuroprotective effect in both in vivo and in vitro models of PD via regulating MALAT1 and α-synuclein expression. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27470562 MALAT1 esophageal cancer Expression The expression of MALAT1 could be a predictor for prognosis of EC patients. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27470544 CCEPR hepatocellular carcinoma Regulation Long noncoding RNA CCHE1 indicates a poor prognosis of hepatocellular carcinoma and promotes carcinogenesis via activation of the ERK/MAPK pathway. chr10 59173963 59176464 - Human CCHE1; lncRNA-CCHE1 NR_131782 27427851 MEG3 cholestatic liver injury Regulation LncRNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate Shp mRNA decay. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 27770549 RMRP gastric cancer Regulation LncRNA-RMRP promotes carcinogenesis by acting as a miR-206 sponge and is used as a novel biomarker for gastric cancer. chr9 35657751 35658018 - Human CHH; NME1R; RRP2; RMRP NR_003051 27192121 MALAT1 breast cancer Expression "MALAT1 overexpression was also associated with poor RFS in tamoxifen treated ER-positive breast cancer patients, which might serve as a potential biomarker to predict endocrine treatment sensitivity." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27191888 DANCR prostate cancer Regulation Long noncoding RNA DANCR promotes invasion of prostate cancer throughepigenetically silencing expression of TIMP2/3. chr4 52712454 52714138 + Human AGU2; ANCR; KIAA0114; SNHG13; lncRNA-ANCR NR_024031 27191265 MALAT1 gallbladder cancer Regulation Long non-coding RNA Malat1 promotes gallbladder cancer development by acting as a molecular sponge to regulate miR-206. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27191262 TUSC7 glioma Regulation "Up-regulation of TUSC7 suppressed cellular proliferation and invasion of glioma cells, and accelerated cellular apoptosis." chr3 116709788 116717040 + Human LINC00902; LSAMP-AS1; LSAMP-AS3; LSAMPAS3; NCRNA00295 NR_015391 27766072 UCA1 breast cancer Regulation UCA1 confers tamoxifen resistance to breast cancer cells partly via activating the mTOR signaling pathway. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27765938 CCAT1 glioma Regulation Long non-coding RNA CCAT1 promotes glioma cell proliferation via inhibiting microRNA-410. chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 27765628 H19 ovarian cancer Regulation H19 may be involved in the pathogenesis of ovarian carcinomas. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27673409 UCA1 ovarian cancer Regulation UCA1 may be involved in the pathogenesis of ovarian carcinomas. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27673409 MEG3 nasopharyngeal carcinoma Regulation MEG3 is a tumor suppressive long non-coding RNA in NPC and encourages the development of precise long non-coding RNA-targeted epigenetic therapy against this malignancy. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 27597634 UCA1 bladder cancer Regulation Long non-coding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27591936 AGAP2-AS1 glioma Regulation "Knockdown of AGAP2-AS1 can inhibit the cell proliferation, migration and invasion, while increase the apoptosis cell rates in vitro." chr12 57726240 57728356 + Human PUNISHER NR_027032 27764782 TPT1-AS1 glioma Expression "AGAP2-AS1, LINC01198 and MIR155HG were increased with tumor grade, while TPT1-AS1 was decreased." chr13 45341345 45391483 + Human N/A NR_024458 27764782 LINC01198 glioma Expression "AGAP2-AS1, LINC01198 and MIR155HG were increased with tumor grade, while TPT1-AS1 was decreased." chr13 46455203 46466776 - Human N/A NR_120426 27764782 MIR155HG glioma Expression "AGAP2-AS1, LINC01198 and MIR155HG were increased with tumor grade, while TPT1-AS1 was decreased." chr21 25562145 25575168 + Human BIC; MIRHG2; NCRNA00172 NR_001458 27764782 Tug1 diabetes mellitus Regulation A direct interaction between PGC-1α and Tug1 modulates mitochondrial bioenergetics in podocytes in the diabetic milieu. chr11 3639785 3648814 - Mouse AI316828 NR_002321 27760051 TUG1 chronic kidney disease Regulation The long noncoding RNA Tug1 connects metabolic changes with kidney disease in podocytes. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27760046 SRA nonalcoholic fatty liver disease Regulation A novel function of SRA is promoting hepatic steatosis through repression of ATGL expression. N/A N/A N/A N/A Human N/A N/A 27759039 MIR2052HG breast cancer Regulation "NAi-mediated silencing of MIR2052HG in breast cancer cell lines decreased Erα expression, cell proliferation and anchorage-independent colony formation." chr8 74599866 74758352 + Human N/A NR_033830 27758888 Ppp1r1b congenital heart defect Regulation "Ppp1r1b-lncRNA was identified as a regulator of Tcap expression, with dynamic interaction in postnatal cardiac development and congenital heart defects." N/A N/A N/A N/A Human N/A N/A 27591185 GPC3-AS1 hepatocellular carcinoma Regulation "GPC3-AS1 significantly promotes HCC progression via epigenetically activating GPC3, and identifies GPC3-AS1 as a potential therapeutic target for HCC." N/A N/A N/A N/A Human N/A N/A 27573079 GIHCG hepatocellular carcinoma Regulation Long noncoding RNA GIHCG promotes hepatocellular carcinoma progression through epigenetically regulating miR-200b/a/429. N/A N/A N/A N/A Human N/A N/A 27380494 ENSMUST00000147869 diabetic nephropathy Regulation Long non-coding RNA ENSMUST00000147869 protects mesangial cells from proliferation and fibrosis induced by diabetic nephropathy. N/A N/A N/A N/A Human N/A N/A 27083175 HOTAIR gastric cancer Regulation Dioscin inhibits gastric tumor growth through regulating the expression level of lncRNA HOTAIR. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27751178 RP11-702B10.1 esophageal cancer Expression LncRNA signature has clinical significance for the prognosis of patients with ESCC. chr11 128208829 128241441 + Human LINC02098 ENST00000609260 27714034 RP11-523H24.3 esophageal cancer Expression LncRNA signature has clinical significance for the prognosis of patients with ESCC. chr13 19674624 19675884 + Human PSPC1-AS2 ENST00000423023 27714034 H19 ulcerative colitis Expression The destructive effect of H19 overexpression on intestinal epithelial barrier function and suggests a potential role of H19 in the development of UC. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27661667 CYTOR colon cancer Expression Linc00152 as a candidate prognostic indicator of outcome and drug responsiveness in colon cancer patients chr2 87455455 87521518 + Human C2orf59; LINC00152; NCRNA00152 NR_024204 27633443 H19 pancreatic ductal adenocarcinoma Regulation The long noncoding RNA H19 promotes cell proliferation via E2F-1 in pancreatic ductal adenocarcinoma chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27573434 HOTTIP hepatocellular carcinoma Expression "Dysregulation of HOTTIP is associated with various malignancies including hepatocellular carcinoma, pancreatic cancer, gastric cancer and colorectal cancer." chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 27546609 HOTTIP pancreatic cancer Expression "Dysregulation of HOTTIP is associated with various malignancies including hepatocellular carcinoma, pancreatic cancer, gastric cancer and colorectal cancer." chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 27546609 HOTTIP gastric cancer Expression "Dysregulation of HOTTIP is associated with various malignancies including hepatocellular carcinoma, pancreatic cancer, gastric cancer and colorectal cancer." chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 27546609 HOTTIP colorectal cancer Expression "Dysregulation of HOTTIP is associated with various malignancies including hepatocellular carcinoma, pancreatic cancer, gastric cancer and colorectal cancer." chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 27546609 KIAA0087 endometrial cancer Regulation lncRNA may be the core regulators ofendometrial carcinogenesis. chr7 26533121 26538825 - Human N/A NR_022006 27748922 RP11-501O2 endometrial cancer Regulation lncRNA may be the core regulators ofendometrial carcinogenesis. chr3 148280891 148399956 + Human LINC02046 ENST00000481334 27748922 FAM212B-AS1 endometrial cancer Regulation lncRNA may be the core regulators ofendometrial carcinogenesis. chr1 111739841 111747798 + Human N/A NR_038952 27748922 LOC102723552 endometrial cancer Regulation lncRNA may be the core regulators ofendometrial carcinogenesis. N/A N/A N/A N/A Human N/A N/A 27748922 RP11-140I24 endometrial cancer Regulation lncRNA may be the core regulators ofendometrial carcinogenesis. chr16 73386805 73421393 + Human LINC01568 ENST00000561875 27748922 RP11-600K151 endometrial cancer Regulation lncRNA may be the core regulators ofendometrial carcinogenesis. N/A N/A N/A N/A Human N/A N/A 27748922 HOTAIR acute leukemia Regulation It may be involved in the development of leukemia by mediating methylation of DNA and histones. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27748863 GAS5 prostate cancer Regulation LncRNA GAS5 inhibits proliferation and progression of prostate cancer by targeting miR-103 through AKT/mTOR signaling pathway. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 27743383 PCA3 prostate cancer Expression "Snail-activated long non-coding RNA PCA3 up-regulates PRKD3 expression by miR-1261 sponging, thereby promotes invasion and migration of prostate cancer cells." chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 27743381 H19 malignant digestive cancer Expression "The patient group of high H19 expression had a higher risk of poorly differentiated grade, deep tumor invasion (T2 stage or more), lymph node metastasis, and advanced TNM stage than the group of low H19 expression," chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27738631 HOTTIP glioma Expression Over-expression of the long non-coding RNA HOTTIP inhibits glioma cell growth by BRE. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 27733185 GAPLINC gastric cancer Expression GAPLINC was overexpressed in GC tissues and promoted tumor migration and invasive behavior. chr18 3466250 3478978 + Human LINC01540 NR_110428 27729869 ENST00000438347 hepatocellular carcinoma Expression ENST00000438347 was up-regulated in MHCC97H-OXA cells as well as chemo-resistant HCC cancerous tissues. chr10 30403197 30403776 - Human CCND3P1 ENST00000438347 27729273 LINC00601 hepatocellular carcinoma Expression NR_073453 was up-regulated in MHCC97H-OXA cells as well as chemo-resistant HCC cancerous tissues. chr10 126413869 126421879 - Human N/A NR_073453 27729273 CXCL1P1 hepatocellular carcinoma Expression ENST00000502804 was up-regulated in MHCC97H-OXA cells as well as chemo-resistant HCC cancerous tissues. chr4 73944011 73944324 - Human CXCL1P1 ENST00000502804 27729273 CASC11 hepatocellular carcinoma Expression The expression of ENST00000518376 was significantly associated with the tumor size and differentiation. chr8 127700608 127733967 - Human CARLo-7; LINC00990; TCONS_00014535 NR_117101 27729273 CTD-2616J11.14 gastric cancer N/A The lncRNA was significantly associated with the overall survival of patients with gastric cancer. chr19 51394488 51403650 + Human AC008750.7 ENST00000600765 27727196 RP1-90G24.10 gastric cancer N/A The lncRNA was significantly associated with the overall survival of patients with gastric cancer. chr22 32205115 32269666 + Human SLC5A4-AS1 ENST00000434942 27727196 RP11-150O12.3 gastric cancer N/A The lncRNA was significantly associated with the overall survival of patients with gastric cancer. chr8 37597480 37599858 - Human AC124067.4 ENST00000522471 27727196 RP11-1149O23.2 gastric cancer N/A The lncRNA was significantly associated with the overall survival of patients with gastric cancer. chr8 23189279 23190675 + Human TNFRSF10A-AS1 ENST00000518308 27727196 MAP3K20-AS1 gastric cancer N/A The lncRNA was significantly associated with the overall survival of patients with gastric cancer. chr2 173197712 173282036 - Human MLK7-AS1 NR_033882 27727196 BC032469 esophageal squamous cell carcinoma Regulation Upregulated long non-coding RNA BC032469 enhances carcinogenesis and metastasis of esophageal squamous cell carcinoma through regulating hTERT expression. N/A N/A N/A N/A Human N/A N/A 27726103 MALAT1 uveal melanoma Regulation Long noncoding RNA MALAT1 promotes uveal melanoma cell growth and invasion by silencing of miR-140. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27725873 DANCR breast cancer Regulation The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer. chr4 52712454 52714138 + Human AGU2; ANCR; KIAA0114; SNHG13; lncRNA-ANCR NR_024031 27716745 H19 gallbladder cancer Regulation Long non-coding RNA H19 regulates FOXM1 expression by competitively binding endogenous miR-342-3p in gallbladder cancer. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27716361 LRRC75A-AS1 rheumatoid arthritis Expression The dysregulation of ENST00000483588 may be involved in the pathological processes of RA chr17 16438987 16470648 + Human C17orf45; C17orf76-AS1; FAM211A-AS1; NCRNA00188; TSAP19 NR_045028 27716329 ENST00000438399 rheumatoid arthritis Expression The dysregulation of ENST00000438399 may be involved in the pathological processes of RA N/A N/A N/A N/A Human N/A N/A 27716329 uc004afb.1 rheumatoid arthritis Expression The dysregulation of uc004afb.1 may be involved in the pathological processes of RA N/A N/A N/A N/A Human N/A N/A 27716329 RPKG1-AS1 rheumatoid arthritis Expression The dysregulation of ENST00000452247 may be involved in the pathological processes of RA N/A N/A N/A N/A Human N/A N/A 27716329 CRNDE renal cell carcinoma Expression Highly expressed lncRNA CRNDE promotes cell proliferation through Wnt/β-catenin signaling in renal cell carcinoma. chr16 54845189 54929189 - Human CRNDE ENST00000613942 27714674 NEXN-AS1 lung cancer N/A A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer. chr1 77881348 77889539 - Human C1orf118 NR_103535 27713484 uc.338 lung cancer Locus Knockdown of Long Noncoding RNA uc.338 by siRNA Inhibits Cellular Migration and Invasion in Human Lung Cancer Cells. N/A N/A N/A N/A Human N/A N/A 27712590 MALAT1 hemangioma Locus MALAT1 knockdown induced apoptosis and S-phase cell cycle arrest in human umbilical vein endothelial cells (HUVECs). chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27709553 PVT1 esophageal cancer Regulation Upregulation of lncRNA PVT1 may induce epithelial-to-mesenchymal transition (EMT) by regulating the expression levels of EMT markers chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 27698800 LINC-ROR colorectal cancer Regulation The long non-coding RNA-ROR promotes the resistance of radiotherapy for human colorectal cancer cells by targeting the P53/miR-145 pathway. chr18 57054571 57072119 - Human ROR; lincRNA-RoR NR_048536 27696511 MALAT1 thyroid cancer Locus MALAT1 may function both as an oncogene and as a tumor suppressor in different types of thyroid tumors. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27696303 HOTAIR lung cancer Regulation "A specific negative regulation loop of lncRNA HOTAIR and p53 in NSCLC cells, which revealed a new understanding of tumorigenesis in p53 dysfunction NSCLC cells." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27695348 UCA1 gastric cancer Regulation Long Non-Coding RNA (LncRNA) Urothelial Carcinoma Associated 1 (UCA1) Increases Multi-Drug Resistance of Gastric Cancer via Downregulating miR-27b. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27694794 TUG1 ovarian cancer Regulation Long non-coding RNA TUG1 regulates ovarian cancer proliferation and metastasis via affecting epithelial-mesenchymal transition. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27693324 HOTAIR ovarian cancer Locus HOTAIR rs920778 polymorphism is associated with ovarian cancer susceptibility and poor prognosis in a Chinese population. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27690631 MSNP1AS autism spectrum disorder Regulation The mechanisms by which MSNP1AS overexpression impacts neuronal differentiation may involve protein synthesis and chromatin structure. N/A N/A N/A N/A Human N/A N/A 27690106 uc.345 pancreatic cancer Regulation Long noncoding RNA uc.345 promotes tumorigenesis of pancreatic cancer by upregulation of hnRNPL expression. N/A N/A N/A N/A Human N/A N/A 27689400 GATA6-AS1 chronic lymphocytic leukemia Locus BM742401 is a tumor suppressor lncRNA inactivated by DNA methylation in chronic lymphocytic leukemia (CLL). chr18 22166898 22168968 - Human BM742401; locus5689 NR_102763 27689399 GATA6-AS1 gastric cancer Expression BM742401 is a tumor suppressor lncRNA downregulated in gastric cancer. chr18 22166898 22168968 - Human BM742401; locus5689 NR_102763 27689399 CDKN2B-AS1 osteosarcoma Regulation Long noncoding RNA ANRIL is activated by hypoxia-inducible factor-1α and promotes osteosarcoma cell invasion and suppresses cell apoptosis upon hypoxia. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 27688736 lnc-MGC diabetic nephropathy Regulation "A chemically modified oligonucleotide targeting lnc-MGC inhibits cluster microRNAs, glomerular ECM and hypertrophy in diabetic mice. " N/A N/A N/A N/A Mouse N/A N/A 27686049 HOTAIR cervical cancer Expression Those exhibiting high HOTAIR levels and molecular signatures of metastasis and those lacking such signatures in the presence of low HOTAIR expression levels. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27683269 LOC285194 colorectal cancer Expression "Long non-coding RNAs LOC285194, RP11-462C24.1 and Nbla12061 in serum provide a new approach for distinguishing patients with colorectal cancer from healthy controls." N/A N/A N/A N/A Human N/A N/A 27683121 RP11-462C24.1 colorectal cancer Expression "Long non-coding RNAs LOC285194, RP11-462C24.1 and Nbla12061 in serum provide a new approach for distinguishing patients with colorectal cancer from healthy controls." N/A N/A N/A N/A Human N/A N/A 27683121 SNHG16 colorectal cancer Expression "Long non-coding RNAs LOC285194, RP11-462C24.1 and Nbla12061 in serum provide a new approach for distinguishing patients with colorectal cancer from healthy controls." chr17 76557764 76565348 + Human Nbla10727; Nbla12061; ncRAN NR_038111 27683121 PCGEM1 prostate cancer Expression PCGEM1 is a long non-coding RNA (lncRNA) that is often upregulated in prostate cancer. chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 27682980 H19 gastric cancer N/A H19 plays a key role in tumorigenesis chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27672656 lncCAMTA1 liver cancer Regulation Long Noncoding RNA lncCAMTA1 Promotes Proliferation and Cancer Stem Cell-Like Properties of Liver Cancer by Inhibiting CAMTA1. N/A N/A N/A N/A Human N/A N/A 27669232 ASAP1-IT1 ovarian cancer N/A Long non-coding RNAs (lncRNAs) are a class of non-protein coding transcripts that has gained significant attention lately due to their important biological actions and potential involvement in cancer. chr8 130295355 130296533 - Human ASAP1-IT; ASAP1IT; ASAP1IT1; DDEF1IT1; HSPC054; NCRNA00050 NR_002765 27667152 FAM215A ovarian cancer N/A Long non-coding RNAs (lncRNAs) are a class of non-protein coding transcripts that has gained significant attention lately due to their important biological actions and potential involvement in cancer. chr17 43917208 43917987 + Human APR-2; C17orf88; LINC00530 NR_026770 27667152 LINC00472 ovarian cancer N/A Long non-coding RNAs (lncRNAs) are a class of non-protein coding transcripts that has gained significant attention lately due to their important biological actions and potential involvement in cancer. chr6 71407864 71420745 - Human C6orf155 NR_121612 27667152 DSCAM-AS1 breast cancer Regulation DSCAM-AS1 mediates tumour progression and tamoxifen resistance and identify hnRNPL as an interacting protein involved in the mechanism of DSCAM-AS1 action. chr21 40383083 40385358 + Human M41 NR_038900 27666543 NEAT1 endometrial cancer Regulation "Overexpression of long noncoding RNA, NEAT1 promotes cell proliferation, invasion and migration in endometrial endometrioid adenocarcinoma." chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27664948 RP11-248E9.5 pneumonia N/A These novel lncRNAs and their target genes may be closely associated with the progression of pneumonia. chr12 87795733 87802028 + Human LINC02258 ENST00000551280 27663962 RP11-456D7.1 pneumonia N/A These novel lncRNAs and their target genes may be closely associated with the progression of pneumonia. chr17 48185938 48204529 + Human SKAP1-AS1 ENST00000582246 27663962 CPS1-IT1 lung cancer Regulation Long noncoding RNA CPS1-IT1 suppresses cell proliferation and metastasis in human lung cancer. chr2 210617571 210619876 + Human CPS1-IT; CPS1IT; CPS1IT1; PRO0132 NR_002763 27662619 HOTAIR osteosarcoma Locus "HOTAIR functioned as a carcinogenic lncRNA, which could promote the proliferation and inhibit the apoptosis of MG-63 cells in vitro." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27660759 HOTAIR gastrointestinal stromal tumor Regulation Promoter methylation of PCDH10 by HOTAIR regulates the progression of gastrointestinal stromal tumors. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27659532 TUG1 osteosarcoma Regulation Long non-coding RNA TUG1 contributes to tumorigenesis of human osteosarcoma by sponging miR-9-5p and regulating POU2F1 expression. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27658774 MALAT1 cervical cancer Expression MiR-375 Is Epigenetically Downregulated by HPV-16 E6 Mediated DNMT1 Upregulation and Modulates EMT of Cervical Cancer Cells by Suppressing lncRNA MALAT1. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27658300 ERL Marek's disease Locus "The 7493-nt ERL lncRNA (edited repeat-long long non-coding RNA), which may act as a natural antisense transcript (NAT) of the major GaHV-2 oncogene meq and of two of the three miRNA clusters." N/A N/A N/A N/A Human N/A N/A 27655063 MALAT1 renal cell carcinoma Regulation lncRNA MALAT-1-mediated promotion of RCC proliferation and metastasis may be due to the upregulation of the expression of Livin. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27655020 ZFAS1 gastric cancer N/A LncRNAs play critical roles in gastric cancer (GC) chr20 49278178 49289260 + Human C20orf199; HSUP1; HSUP2; NCRNA00275; ZNFX1-AS1 NR_036658 27654478 HOXA11-AS gastric cancer Regulation "LncRNA HOXA11-AS promotes proliferation and invasion of gastric cancer by scaffolding the chromatin modification factors PRC2, LSD1 and DNMT1." chr7 27185408 27189293 + Human HOXA-AS51; HOXA11AS; HOXA11S; NCRNA00076; HOXA11-AS NR_002795 27651312 lnc-RTN4R-1 acute lymphoblastic leukemia N/A Lnc-RTN4R-1 and lnc-NKX2-3-1 as lncRNAs that might be functionally implicated in the biology of this prevalent subtype of human leukemia. N/A N/A N/A N/A Human N/A N/A 27650541 lnc-NKX2-3-1 acute lymphoblastic leukemia N/A Lnc-RTN4R-1 and lnc-NKX2-3-1 as lncRNAs that might be functionally implicated in the biology of this prevalent subtype of human leukemia. N/A N/A N/A N/A Human N/A N/A 27650541 NONHSAT089447 schizophrenia N/A LncRNA NONHSAT089447 and NONHSAT041499 might be involved in the pathogenesis and development of SZ N/A N/A N/A N/A Human N/A N/A 27650396 NONHSAT041499 schizophrenia N/A LncRNA NONHSAT089447 and NONHSAT041499 might be involved in the pathogenesis and development of SZ N/A N/A N/A N/A Human N/A N/A 27650396 MALAT1 osteosarcoma Expression MALAT1 may be considered as a prognostic biomarker and therapeutic target for osteosarcoma. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27649655 CASC2 gastric cancer Regulation CASC2 might serve as a tumor suppressor lncRNA that suppressed cell proliferation by inactivation of MAPK pathway. chr10 118046821 118210153 + Human C10orf5 NR_026939 27648142 HNF1A-AS1 osteosarcoma Regulation Upregulation of lncRNA HNF1A-AS1 promotes cell proliferation and metastasis in osteosarcoma through activation of the Wnt/β-catenin signaling pathway. chr12 120969838 120972292 - Human C12orf27; NCRNA00262 NR_024345 27648140 IRAIN pancreatic cancer Regulation Long non-coding RNA IRAIN suppresses apoptosis and promotes proliferation by binding to LSD1 and EZH2 in pancreatic cancer chr15 98645863 98651221 - Human IGF1R-AS NR_126453 27644252 GACAT3 gastric cancer Regulation Novel long non-coding RNA GACAT3 promotes gastric cancer cell proliferation through the IL-6/STAT3 signaling pathway chr2 16050427 16085689 + Human LINC01458; lncRNA-AC130710 NR_126559 27644247 SPRY4-IT1 cervical cancer Regulation "LncRNA SPRY4-IT1 may be a novel molecule involved in cervical cancer progression, which may be of use as both a potential predictor and therapeutic target." chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 27642559 PCBP2-OT1 tongue squamous cell carcinoma Expression Long noncoding RNA TUC338 overexpression leads to enhanced proliferation and reduced apoptosis in TSCC. chr12 53464468 53465057 + Human TUC338 NR_109828 27637778 CRNDE gallbladder cancer Regulation Long non-coding RNA CRNDE promotes gallbladder carcinoma carcinogenesis chr16 54845189 54929189 - Human CRNDE ENST00000613942 27637083 TUG1 colon cancer Expression Overexpression of Long Non-Coding RNA TUG1 Promotes Colon Cancer Progression. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27634385 H19 cervical cancer Regulation H19 promotes both anchorage-specific and -independent growth of cervical cancer cell lines and may serve as a potential target for cancer diagnosis and therapy. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27633578 LINC00312 bladder cancer Regulation LINC00312 inhibited BC cell invasion and metastasis through mediating miR-197-3p. chr3 8571782 8574668 + Human ERR-10; ERR10; LMCD1DN; LOH3CR2A; NAG-7; NAG7; NCRNA00312 NR_024065 27631965 GAS5 non-small cell lung cancer Expression Circulating long noncoding RNA GAS5 is a novel biomarker for the diagnosis of nonsmall cell lung cancer. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 27631209 PANDAR colorectal cancer Expression The high expression of long non-coding RNA PANDAR indicates a poor prognosis for colorectal cancer and promotes metastasis by EMT pathway. chr6 36673621 36675126 - Human PANDA NR_109836 27629879 UCA1 breast cancer Regulation Long non-coding RNA UCA1 enhances tamoxifen resistance in breast cancer cells through a miR-18a-HIF1α feedback regulatory loop. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27629141 AFAP1-AS1 pancreatic ductal adenocarcinoma Expression "High AFAP1-AS1, UCA1 and low ENSG00000218510 expression were correlated with several tumorigenesis related pathways." chr4 7754090 7778928 + Human AFAP1-AS; AFAP1AS NR_026892 27628540 UCA1 pancreatic ductal adenocarcinoma Expression "High AFAP1-AS1, UCA1 and low ENSG00000218510 expression were correlated with several tumorigenesis related pathways." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27628540 LINC00339 pancreatic ductal adenocarcinoma Expression "High AFAP1-AS1, UCA1 and low ENSG00000218510 expression were correlated with several tumorigenesis related pathways." chr1 22025191 22031224 + Human HSPC157; NCRNA00339 NR_109760 27628540 H19 pneumoconiosis Mutation Polymorphisms in Long Noncoding RNA H19 Contribute to the Protective Effects of Coal Workers' Pneumoconiosis in a Chinese Population. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27626436 LINC00520 breast cancer N/A "LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer." chr14 55781135 55796674 - Human C14orf34 NR_026796 27626181 NR_026689 ovarian cancer Locus Knockdown of long noncoding RNA NR_026689 inhibits proliferation and invasion and increases apoptosis in ovarian carcinoma HO-8910PM cells. N/A N/A N/A N/A Human N/A N/A 27624216 HIF-2α osteosarcoma Expression HIF-2α and HIF2PUT upregulation may be a common feature in human osteosarcomas with aggressive potency. N/A N/A N/A N/A Human N/A N/A 27623205 SPRY4-IT1 colorectal cancer Regulation Long noncoding RNA SPRY4-IT1 promotes malignant development of colorectal cancer by targeting epithelial-mesenchymal transition. chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 27621655 XIST gastric cancer Expression lncRNA XIST is up-regulated and is associated with aggressive tumor phenotypes and patient survival in gastric cancer chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 27620004 Chaer cardiac hypertrophy Regulation The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. N/A N/A N/A N/A Human N/A N/A 27618650 CYTOR breast cancer N/A CYTOR plays a role in breast cancer. chr2 87455455 87521518 + Human C2orf59; LINC00152; NCRNA00152 NR_024204 27617288 RNCR3 diabetes mellitus Locus RNCR3 knockdown may be a promising strategy for the prevention of diabetes mellitus-induced retinal neurodegeneration. N/A N/A N/A N/A Human N/A N/A 27616193 NKILA tongue squamous cell carcinoma Regulation Long non-coding RNA NKILA inhibits migration and invasion of tongue squamous cell carcinoma cells via suppressing epithelial-mesenchymal transition. chr20 57710183 57712780 + Human N/A NR_131157 27613832 HOTAIR ischemic stroke Regulation Long non-coding RNA HOTAIR promotes ischemic infarct induced by hypoxia through up-regulating the expression of NOX2. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27613094 NEAT1 ovarian cancer Expression NEAT1 has a potential to function as a clinical biomarker for predicting disease invasiveness and prognosis of patients with OC. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27608895 LINC-ROR gastric cancer Regulation LncRNA ROR was associated with core stemness transcriptional factors and the pluripotent state of GCSCs chr18 57054571 57072119 - Human ROR; lincRNA-RoR NR_048536 27602437 uc009yby.1 renal cell carcinoma Regulation LncRNA uc009yby.1 promotes renal cell proliferation and is associated with poor survival in patients with clear cell renal cell carcinomas. N/A N/A N/A N/A Human N/A N/A 27602119 AC145110.1 breast cancer Regulation LncRNAs might be involved in breast tumorigenesis through the modulation of gene expression in multiple pathologic pathways. chr8 29748309 29798492 + Human LINC02099 ENST00000517491 27597120 RP1-13P20.6 colorectal cancer Expression LncRNA-RP1-13P20.6 is a potential biomarker for CRC. N/A N/A N/A N/A Human N/A N/A 27596299 H19 gastric cancer Expression "Serum H19 and LINC00152 may serve as potential biomarkers for diagnosis of GC, particularly for those with H. pylori infection." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27592063 CYTOR gastric cancer Expression "Serum H19 and LINC00152 may serve as potential biomarkers for diagnosis of GC, particularly for those with H. pylori infection." chr2 87455455 87521518 + Human C2orf59; LINC00152; NCRNA00152 NR_024204 27592063 LEF1-AS1 colorectal cancer Expression NR_029373 and NR_034119 are potential biomarkers for CRC prognosis prediction. chr4 108167525 108176430 + Human LEF1NAT NR_029374 27591862 LINC00460 colorectal cancer Expression NR_029373 and NR_034119 are potential biomarkers for CRC prognosis prediction. chr13 106376563 106377792 + Human N/A NR_034119 27591862 MALAT1 retinal neurodegeneration Regulation Long non-coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27587362 TINCR bladder cancer N/A TINCR may be the potential therapeutic target for treating bladder urothelial carcinoma. chr19 5558167 5568034 - Human LINC00036; NCRNA00036; PLAC2; onco-lncRNA-16 NR_027064 27586866 MALAT1 tongue squamous cell carcinoma Regulation Long non-coding RNA MALAT-1 modulates metastatic potential of tongue squamous cell carcinomas partially through the regulation of small proline rich proteins. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27586393 MALAT1 nasopharyngeal carcinoma Regulation RBM24 suppresses cancer progression by upregulating miR 25 to target MALAT1 in nasopharyngeal carcinoma. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27584791 TDRG1 esophageal squamous cell carcinoma Expression LincRNA-NR_024015 may be a useful marker for the prediction of the biological behavior of ESCC. chr6 40378424 40379892 + Human LINC00532 NR_024015 27583835 AFAP1-AS1 colorectal cancer Regulation Long non-coding RNA AFAP1-AS1 facilitates tumor growth and promotes metastasis in colorectal cancer. chr4 7754090 7778928 + Human AFAP1-AS; AFAP1AS NR_026892 27578191 FENDRR non-small cell lung cancer Regulation "Loss of long noncoding RNA FOXF1-AS1 regulates epithelial-mesenchymal transition, stemness and metastasis of non-small cell lung cancer cells." chr16 86474525 86508860 - Human FOXF1-AS1; TCONS_00024240; lincFOXF1; onco-lncRNA-21 NR_033925 27577075 HOXC-AS1 atherosclerosis Regulation Induction of cholesterol accumulation by Ox-LDL could be partly suppressed by overexpression of HOXC-AS1. chr12 53999022 54000010 - Human N/A NR_047504 27574949 ZFAS1 hepatocellular carcinoma Regulation ZNFX1-AS1 plays a vital role in HCC progression via regulating the methylation of miR-9 and may be a potential tumor suppressor. chr20 49278178 49289260 + Human C20orf199; HSUP1; HSUP2; NCRNA00275; ZNFX1-AS1 NR_036658 27574442 HOTAIR cervical cancer Locus HOTAIR plays an important oncogenic role in cervical cancer and might serve as a marker for cervical cancer prognosis and a potential target for therapeutic intervention. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27574106 CCAT1 lung adenocarcinoma Locus Long noncoding RNA CCAT1 acts as an oncogene and promotes chemoresistance in docetaxel-resistant lung adenocarcinoma cells. chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 27566568 PCAT14 prostate cancer Expression PCAT14 is highly expressed in low grade disease and loss of PCAT14 predicts for disease aggressiveness and recurrence. chr22 23538102 23547306 + Human N/A NR_109832 27566105 LOC100505976 laryngeal squamous cell carcinoma N/A LOC100505976 might play pivotal roles in the tumorigenesis of LSCC. N/A N/A N/A N/A Human N/A N/A 27565327 XLOC_l2_010636 laryngeal squamous cell carcinoma N/A XLOC_l2_010636 might play pivotal roles in the tumorigenesis of LSCC. N/A N/A N/A N/A Human N/A N/A 27565327 MALAT1 ovarian cancer Expression "MALAT1 is a potential biomarker for tumor growth and metastasis, as well as a promising therapeutic target in ovarian cancer, facilitating further ovarian cancer research." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27565324 MALAT1 melanoma Regulation Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27564100 UCA1 oral squamous cell carcinoma Regulation Long non-coding RNA UCA1 contributes to the progression of oral squamous cell carcinoma via regulating WNT/β-catenin signaling pathway. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27560546 CCAT2 prostate cancer Expression The up-regulation of long non-coding RNA CCAT2 indicates a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial-mesenchymal transition. chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 27558961 CDKN2B-AS1 nasopharyngeal carcinoma Expression "LncRNA ANRIL is up-regulated in nasopharyngeal carcinoma and promotes the cancer progression via increasing proliferation, reprograming cell glucose metabolism and inducing side-population stem-like cancer cells." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 27557514 NEAT1 glioma Locus "NEAT1 knockdown inhibited GSC cell proliferation, migration and invasion and promoted GSC apoptosis." chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27556696 lncRNA-ATB pneumoconiosis Expression Elevated lncRNA-ATB was associated with CWP risk and may serve as a potential biomarker for CWP. N/A N/A N/A N/A Human N/A N/A 27556453 LINC01138 prostate cancer Regulation LINC01138 promoted the proliferation and inhibited apoptosis of PCa. chr1 148432959 148459920 - Human LINC00875 NR_027468 27556357 SUZ12P1 prostate cancer Regulation SUZ12P1 promoted the proliferation and inhibited apoptosis of PCa. chr17 30709299 30790908 + Human SUZ12P1 ENST00000578070 27556357 NEAT1 breast cancer Regulation The dysregulation of the BRCA1/NEAT1/miR-129-5p/WNT4 signaling axis is involved in promoting breast tumorigenesis. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27556296 91H osteosarcoma Expression 91H may be a novel biomarker for risk prognostication and also provide a clue to the molecular etiology of osteosarcoma. N/A N/A N/A N/A Human N/A N/A 27555785 SLC25A25-AS1 colorectal cancer Regulation "Decreased expression of LncRNA SLC25A25-AS1 promotes proliferation, chemoresistance, and EMT in colorectal cancer cells." chr9 128111171 128118734 - Human N/A NR_033374 27553025 HOTAIR large B-Cell lymphoma Regulation "HOTAIR expression could be one of possible mechanisms for inducing H3K27me3 via EZH2-related PRC2 activation, and induced H3K27me3 may be strongly related to aggressive DLBCLs which show poor patient outcome." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27550047 HOTAIR papillary thyroid carcinoma Locus HOTAIR acts as a PTC oncogene via promoting tumorigenic properties of PTC cells. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27549736 H19 glioma Regulation Long non-coding RNA H19 regulates glioma angiogenesis and the biological behavior of glioma-associated endothelial cells by inhibiting microRNA-29a. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27543358 SNHG20 colorectal cancer Expression Dysregulation of SNHG20 participates in CRC progression and may serve as a potential therapeutic target in CRC patients. chr17 77088643 77094986 + Human C17orf86; LINC00338; NCRNA00338; SCARNA16HG NR_027058 27543107 HOTAIR laryngeal squamous cell carcinoma Regulation "Suppressing HOTAIR expression stimulated EZH2 expressing, promoted the proliferation of AMC-HN8 cells, and increased the sensitivity to cis-platinum of the LSCC cells." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27542077 H19 breast cancer Expression Plasma H19 may serve as a potential biomarker for BC early screening and prognosis monitor. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27540977 UCA1 endometrial cancer Expression The UCA1 plays an important role in the metastasis of EC and may serve as a novel molecular marker to predict the aggressive tumor progression and unfavorable prognosis of EC patients. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27540975 XIST B-cell acute lymphoblastic leukemia N/A "XIST may play important roles in the development of B-ALL, serving as a potential therapeutic target." chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 27535859 MIR22HG ovarian cancer Locus C17orf91 was a potential prognostic marker and functioned as an oncogene in ovarian cancer. chr17 1711504 1716272 - Human C17orf91 NR_028502 27535740 SNHG6 hepatocellular carcinoma Regulation "The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma." chr8 66921930 66925542 - Human HBII-276HG; NCRNA00058; U87HG NR_002599 27530352 UFC1 osteoarthritis Regulation Long Noncoding RNA UFC1 Promotes Proliferation of Chondrocyte in Osteoarthritis by Acting as a Sponge for miR-34a. N/A N/A N/A N/A Human N/A N/A 27529373 MALAT1 renal cell carcinoma Expression MALAT1 could function as potential prognostic markers in RCC. MALAT1 could also display high accuracy for RCC diagnosis. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27527868 MIAT chronic lymphocytic leukemia Regulation MIAT constitutes a regulatory loop with OCT4 in malignant mature B cell chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 27527866 PCAT1 prostate cancer Regulation PCAT1 promotes prostate cancer cell proliferation and tumor growth in vitro and in vivo. chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 27526323 MALAT1 hepatocellular carcinoma Regulation There is a HIF-2α-MALAT1-miR-216b axis regulating MDR of HCC cells via modulating autophagy. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27524242 RBM5-AS1/LUST colon cancer N/A RBM5-AS1 activity is critical for the functional enablement of colon cancer stem-like cells. N/A N/A N/A N/A Human N/A N/A 27520449 NONRATT021972 diabetic cardiac autonomic neuropathy Regulation Inhibition of NONRATT021972 may serve as a novel therapeutic strategy for preventing the development of DCAN. N/A N/A N/A N/A Rat N/A N/A 27519467 linc-223 acute myeloid leukemia N/A LncRNA linc-223 may have an important role in myeloid differentiation and leukemogenesis N/A N/A N/A N/A Human N/A N/A 27517498 SNHG1 neuroblastoma Expression SNHG1 is up-regulated by MYCN amplification and could be a potential prognostic biomarker for high-risk NB intervention. chr11 62851988 62855888 - Human LINC00057; NCRNA00057; U22HG; UHG; lncRNA16 NR_003098 27517149 BANCR bladder cancer Regulation Over-expression of long noncoding RNA BANCR inhibits malignant phenotypes of human bladder cancer. chr9 69296681 69307056 - Human LINC00586 NR_047671 27514530 MFI2 osteosarcoma Regulation Overexpression of long non-coding RNA MFI2 promotes cell proliferation and suppresses apoptosis in human osteosarcoma. N/A N/A N/A N/A Human N/A N/A 27513470 POIR periodontitis Expression It has potential as a therapeutic target in mesenchymal stem cells during inflammation. N/A N/A N/A N/A Human N/A N/A 27512949 MALAT1 osteosarcoma Expression The expression of MALAT1 is high in osteosarcoma and correlates with tumor metastasis. MALAT1 promotes invasion and metastasis of osteosarcoma cells likely thought the Wnt/β-catenin signal pathway. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27510783 LOC729966 papillary thyroid carcinoma Expression NR_036575.1 could be applied as a potential biomarker and a novel therapeutic target for PTC patients. chr19 18249950 18255419 - Human N/A NR_036575 27510368 Tug1 atherosclerosis Regulation Tanshinol suppresses endothelial cells apoptosis in mice with atherosclerosis via lncRNA TUG1 up-regulating the expression of miR-26a. chr11 3639785 3648814 - Mouse AI316828 NR_002321 27508018 CDKN2B-AS1 thyroid cancer Regulation Long non-coding RNA ANRIL promotes the invasion and metastasis of thyroid cancer cells through TGF-β/Smad signaling pathway. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 27507052 DUXAP8 gastric cancer Regulation The pseudogene derived long noncoding RNA DUXAP8 promotes gastric cancer cell proliferation and migration via epigenetically silencing PLEKHO1 expression. chr22 15784959 15829984 + Human DUXAP8 ENST00000447898 27507049 CHRF silicosis Regulation The CHRF-miR-489-MyD88 Smad3 signaling axis exerts key functions in silica-induced pulmonary fibrosis and may represent a therapeutic target for silicosis. N/A N/A N/A N/A Human N/A N/A 27506999 PVT1 diabetic kidney disease Expression "Variants in the plasmacytoma variant translocation (PVT1) gene were strongly associated with DKD in the Pima Indians, a group with the highest prevalence of type 2 diabetes in the world." chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 27503944 XIST non-small cell lung cancer Locus Long noncoding RNA XIST acts as an oncogene in non small cell lung cancer by epigenetically repressing KLF2 expression. chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 27501756 n375709 nasopharyngeal carcinoma Regulation LncRNA n375709 was identified to be involved in the regulation of NPC paclitaxel resistance. N/A N/A N/A N/A Human N/A N/A 27498905 HULC colorectal cancer Regulation Long noncoding RNA HULC promotes colorectal carcinoma progression through epigenetically repressing NKD2 expression. chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 27496341 PVT1 hepatocellular carcinoma N/A The long noncoding RNAs PVT1 and uc002mbe.2 in sera provide a new supplementary method for hepatocellular carcinoma diagnosis. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 27495068 MIR7-3HG hepatocellular carcinoma N/A The long noncoding RNAs PVT1 and uc002mbe.2 in sera provide a new supplementary method for hepatocellular carcinoma diagnosis. chr19 4769105 4772556 + Human C19orf30; Huh7; LINC00306; NCRNA00306; PGSF1; uc002mbe.2 NR_027148 27495068 TCL6 renal cell carcinoma Expression Decreased TCL6 expression may be an independent adverse prognostic factor in ccRCC patients. chr14 95651178 95673452 + Human TNG1; TNG2 NR_028288 27494890 GAS5-AS1 non-small cell lung cancer Regulation Downregulation of the long noncoding RNA GAS5-AS1 contributes to tumor metastasis in non-small cell lung cancer. chr1 173863248 173863941 + Human N/A NR_037605 27489122 RBMY2FP hepatocellular carcinoma Regulation Long non-coding RNA RBMY2FP promotes proliferation of male hepatocellular carcinoma by directing DNA methylation and activating RBMY1A1 via DNMT1. chrY 22308859 22321825 + Human RBMY2FP ENST00000420346 27487148 RSU1P2 cervical cancer Regulation LncRNA RSU1P2 contributes to tumorigenesis by acting as a ceRNA against let-7a in cervical cancer cells. chr10 45099487 45154596 - Human RSU1P2 ENST00000619977 27487126 MELOE melanoma Regulation "Within the MELOE family, IRES-dependent antigens represent the best T cell targets for immunotherapy of melanoma." N/A N/A N/A N/A Human N/A N/A 27486971 MALAT1 gastric cancer Expression The lncRNA MALAT1 is a novel biomarker for gastric cancer metastasis. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27486823 TUG1 non-small cell lung cancer Expression Long noncoding RNA TUG1 is downregulated in non-small cell lung cancer and can regulate CELF1 on binding to PRC2. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27485439 LINC01089 breast cancer Regulation LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer. chr12 121795267 121803484 - Human LIMT NR_002809 27485121 HOTAIR ovarian cancer Expression The upregulation of HOTAIR contributed to the malignant progression of ovarian cancer cells. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27484896 PVT1 asthma Regulation Targeting PVT1 might be effective in reducing airway remodeling in asthmatic patients. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 27484035 NEAT1 systemic lupus erythematosus Expression The increased NEAT1 expression may be a potential contributor to the elevated production of a number of cytokines and chemokines in SLE patients. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27481557 MEG3 endometrial cancer Regulation LncRNA-MEG3 inhibits cell proliferation of endometrial carcinoma by repressing Notch signaling. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 27470401 CCAT2 small cell lung cancer Regulation LncRNA CCAT2 predicts poor prognosis and regulates growth and metastasis in small cell lung cancer. chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 27470400 BANCR esophageal squamous cell carcinoma Regulation Upregulation of the long non-coding RNA BANCR correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma. chr9 69296681 69307056 - Human LINC00586 NR_047671 27470379 TMSB4 osteoarthritis Regulation The TMSB4 Pseudogene LncRNA Functions as a Competing Endogenous RNA to Promote Cartilage Degradation in Human Osteoarthritis. N/A N/A N/A N/A Human N/A N/A 27469625 P2RX7-V3 uveal melanoma Expression P2RX7-V3 that plays a crucial role in UM tumorigenesis and may serve as a useful biomarker in the diagnosis and prognosis treatment of UM in the future. N/A N/A N/A N/A Human N/A N/A 27468714 HOTAIR cervical cancer Expression "Functional SNP rs920778 regulates HOTAIR expression, and may ultimately influence the predisposition for cervical cance" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27467165 GAS5 gastric cancer Expression GAS5 is downregulated in gastric cancer cells by promoter hypermethylation and regulates adriamycin sensitivity chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 27466992 MALAT1 breast cancer Expression "MALAT1 upregulation plays an important rolein BC development, and serum MALAT1 level may be a potential tumor marker for BC diagnosis." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27466303 BANCR papillary thyroid carcinoma Regulation BANCR inhibits tumorigenesis in PTC and that BANCR levels may be used as a novel prognostic marker. chr9 69296681 69307056 - Human LINC00586 NR_047671 27462868 XIST nasopharyngeal carcinoma Locus Long non-coding RNA XIST exerts oncogenic functions in human nasopharyngeal carcinoma by targeting miR-34a-5p. chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 27461945 ZFAS1 colorectal cancer Expression Upregulation of long noncoding RNA ZFAS1 predicts poor prognosis and prompts invasion and metastasis in colorectal cancer. chr20 49278178 49289260 + Human C20orf199; HSUP1; HSUP2; NCRNA00275; ZNFX1-AS1 NR_036658 27461828 CDKN2B-AS1 melanoma Regulation ANRIL lncRNA triggers efficient therapeutic efficacy by reprogramming the aberrant INK4-hub in melanoma. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 27461581 SPRY4-IT1 glioma Expression Long noncoding RNA SPRY4-IT1 is a prognostic factor for poor overall survival and has an oncogenic role in glioma. chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 27460732 SBF2-AS1 non-small cell lung cancer Expression Over-expression of lncRNA SBF2-AS1 is associated with advanced tumor progression and poor prognosis in patients with non-small cell lung cancer. chr11 9758293 9811319 + Human N/A NR_036485 27460731 RPLP0P2 lung adenocarcinoma Expression Low expression lncRNA RPLP0P2 is associated with poor prognosis and decreased cell proliferation and adhesion ability in lung adenocarcinoma. chr11 61615036 61639449 + Human RPLP0P2 ENST00000496593 27460542 BCAR4 osteosarcoma Regulation Long noncoding RNA BCAR4 promotes osteosarcoma progression through activating GLI2-dependent gene transcription. chr16 11819830 11828832 - Human N/A NR_024050 27460090 TUG1 bladder cancer Expression Overexpression of long non-coding RNA TUG1 predicts poor prognosis and promotes cancer cell proliferation and migration in high-grade muscle-invasive bladder cancer. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27460088 HOTAIR lung adenocarcinoma Regulation The HOTAIR/miR-326/SP1 pathway regulates chemoresistance of LAD cells. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27460077 AK001094 gastric cancer N/A The five-lncRNA signature may have a good clinical applicability for determining the diagnosis and predicting the prognosis of GC. N/A N/A N/A N/A Human N/A N/A 27460075 AK024171 gastric cancer N/A The five-lncRNA signature may have a good clinical applicability for determining the diagnosis and predicting the prognosis of GC. N/A N/A N/A N/A Human N/A N/A 27460075 AK093735 gastric cancer N/A The five-lncRNA signature may have a good clinical applicability for determining the diagnosis and predicting the prognosis of GC. N/A N/A N/A N/A Human N/A N/A 27460075 BC003519 gastric cancer N/A The five-lncRNA signature may have a good clinical applicability for determining the diagnosis and predicting the prognosis of GC. N/A N/A N/A N/A Human N/A N/A 27460075 NR_003573 gastric cancer N/A The five-lncRNA signature may have a good clinical applicability for determining the diagnosis and predicting the prognosis of GC. chr9 33624274 33625293 + Human ANXA2P2 ENST00000435128 27460075 MALAT1 osteosarcoma Regulation MALAT1 promotes osteosarcoma development by targeting TGFA via MIR376A. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27458156 PCAT6 lung cancer Locus PCAT6 could play an oncogenic role in lung cancer progression and may serve as a biomarker for prognosis of lung cancer patients. chr1 202810946 202811913 + Human KDM5B-AS1; KDM5BAS1; PCAN-R1; ncRNA-a2; onco-lncRNA-96 NR_046326 27458097 SPRY4-IT1 esophageal squamous cell carcinoma Regulation "SPRY4-IT1 is a vital regulator in ESCC progression, and the SPRY4-IT1/ZNF703 axis might provide novel clues for future ESCC therapy." chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 27453415 PICSAR cutaneous squamous cell carcinoma Expression This long noncoding RNA may serve as a useful diagnostic marker and therapeutic target for cutaneous squamous cell carcinoma. chr21 44999208 45004727 - Human C21orf113; LINC00162; NCRNA00162; NLC1-C; NLC1C; PRED74 NR_024089 27450499 GCASPC gallbladder cancer Expression "GCASPC overexpression suppressed cell proliferation in vitro and in vivo, whereas GCASPC silencing had opposite effects." N/A N/A N/A N/A Human N/A N/A 27450454 uc.63 breast cancer Regulation Our results reveal an important role of uc.63 in promoting breast cancer cells survival and offer the prospect to identify a signature associated with poor prognosis. N/A N/A N/A N/A Human N/A N/A 27447964 MALAT1 epithelial ovarian cancer Expression The levels of plasma MALAT1 may act as a valuable biomarker for the diagnosis of metastasis. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27446438 NEAT1 leukemia Expression Overexpression of lncRNA NEAT1 mitigates multidrug resistance by inhibiting ABCG2 in leukemia. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27446393 HOTAIR glioma Regulation MiR-148b-3p inhibits malignant biological behaviors of glioma cells by directly targeting HOTAIR. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27446363 GAS5 melanoma Regulation LncRNA GAS5 is a critical regulator of metastasis phenotype of melanoma cells and inhibits tumor growth in vivo. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 27445498 AK126698 non-small cell lung cancer Regulation Long noncoding RNA AK126698 inhibits proliferation and migration of non-small cell lung cancer cells by targeting Frizzled-8 and suppressing Wnt/β-catenin signaling pathway. N/A N/A N/A N/A Human N/A N/A 27445486 LINC01133 colorectal cancer Regulation Long non-coding RNA LINC01133 inhibits epithelial mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6. chr1 159961224 159979086 + Human N/A NR_038849 27443606 LINC00261 gastric cancer Expression Decreased expression of the long noncoding RNA LINC00261 indicate poor prognosis in gastric cancer and suppress gastric cancer metastasis by affecting the epithelial-mesenchymal transition. chr20 22560553 22578642 - Human ALIEN; C20orf56; DEANR1; HCCDR1; NCRNA00261; onco-lncRNA-17 NR_001558 27439973 MIR31HG bladder cancer Regulation MIR31HG may function as a cancer-suppressor gene to participate in the bladder cancer carcinogenesis and development. chr9 21454268 21559698 - Human hsa-lnc-31 NR_027054 27434291 GAS5 hypertension Regulation This study identifiedGAS5 as a critical regulator in hypertension and demonstrated the potential of gene therapy and drug development for treating hypertension. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 27432865 MEG3 hepatocellular carcinoma Regulation "MEG3 inhibits cell proliferation and induces apoptosis, partially via the activation of the ER stress and p53 pathway," chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 27432655 CCAT1 endometrial cancer Locus CARLo-5 was identified as a pro-oncogeniclncRNA that may play an important role in EC progression and represent a prognostic marker for EC. chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 27432114 CASC9 esophageal cancer Expression CASC9 is significantly upregulated in ESCC tissues and may represent a new marker of poor prognosis and a potential therapeutic target for esophageal cancer intervention. chr8 75223117 75278889 - Human ESCCAL-1; ESSCAL1; LINC00981 NR_103848 27431358 MALAT1 non-small cell lung cancer Expression "MALAT1 significantly increased the migration, invasion and tumorigenesis in vivo, which suggests its important role in the bone metastasis of NSCLC." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27431200 UCA1 breast cancer Regulation LncRNA UCA1 promotes epithelial-mesenchymal transition (EMT) of breast cancer cells via enhancing Wnt/beta-catenin signaling pathway. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27424981 uc004cov.4 hypertrophic cardiomyopathy Expression The specific mitochondrial long noncoding RNAs uc004cov.4 and uc022bqu.1 were upregulated in patients with HOCM and they were also able to identify HOCM and could be developed as useful clinical biomarkers in the future. N/A N/A N/A N/A Human N/A N/A 27422984 uc022bqu.1 hypertrophic cardiomyopathy Expression The specific mitochondrial long noncoding RNAs uc004cov.4 and uc022bqu.1 were upregulated in patients with HOCM and they were also able to identify HOCM and could be developed as useful clinical biomarkers in the future. N/A N/A N/A N/A Human N/A N/A 27422984 TUG1 colorectal cancer Regulation Long non-coding RNA TUG1 promotes colorectal cancer metastasis via EMT pathway chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27421138 MALAT1 gallbladder cancer Expression Inhibition of MALAT1 expression may be to a novel therapeutic strategy for gallbladder cancer. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27420766 BC087858 non-small cell lung cancer Regulation LncRNA BC087858 could promote cells invasion and induce non-T790M mutation acquired resistance to EGFR-TKIs by activating PI3K/AKT and MEK/ERK pathways and EMT via up- regulating ZEB1 and Snail in NSCLC. N/A N/A N/A N/A Human N/A N/A 27409677 GAS5 colorectal cancer Expression GAS5 and Yiya were promising prognostic biomarkers of liver metastases for early stage CRC patients. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 27391432 LINC00538 colorectal cancer Expression GAS5 and Yiya were promising prognostic biomarkers of liver metastases for early stage CRC patients. chr1 213924749 213926654 + Human PROX1UT; Yiya NR_046189 27391432 CLMAT3 colorectal cancer Regulation Reducing lncRNA-CLMAT3 inhibits colorectal cancer cell proliferation by affecting cell cycle components. N/A N/A N/A N/A Human N/A N/A 27391344 SPRY4-IT1 colorectal cancer Locus "SPRY4-IT1 could act as a functional oncogene in CRC, as well as a potential therapeutic target to inhibit CRC metastasis." chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 27391336 MIAT Alzheimer's disease Locus "We show that MIAT knockdown leads to cerebral microvascular degeneration, progressive neuronal loss and neurodegeneration, and behavioral deficits in a CNS neurovascular disorder, Alzheimer's disease." chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 27391072 UCA1 melanoma Regulation "LncRNA UCA1-miR-507-FOXM1 axis is involved in cell proliferation, invasion and G0/G1 cell cycle arrest in melanoma." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27389544 HOTAIR breast cancer Expression "The effective chemopreventive effect of Dp on breast carcinogenesis, in which down-regulation of HOTAIR plays a critical role." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27388461 NEAT1 bladder cancer Regulation NEAT1 may play oncogenic roles and can be used as a therapeutic target for treating human bladder cancer. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27384674 CRNDE medulloblastoma Regulation Long non-coding RNA CRNDE promotes tumor growth in medulloblastoma chr16 54845189 54929189 - Human CRNDE ENST00000613942 27383309 FER1L4 endometrial cancer Regulation LncRNA FER1L4 suppresses cancer cell proliferation and cycle by regulating PTEN expression in endometrial carcinoma. chr20 35558737 35607562 - Human FER1L4 ENST00000615531 27381864 RMST breast cancer N/A RMST was involved in breast cancer chr12 97465021 97533766 + Human LINC00054; NCRMS; NCRNA00054 NR_024037 27380926 HOTAIR breast cancer Regulation "The transcriptional regulation of HOTAIR, identifies HOTAIR and its regulators as novel biomarkers of patient response to endocrine therapy and corroborates the importance of transcriptional enhancers in cancer." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27378691 C6orf176-TV1 non-small cell lung cancer Expression The expression of C6orf176-TV1 or C6orf176-TV2 is down regulated in NSCLC and it is correlated with the grade of differentiation. It may act as a diagnosis indicator for NSCLC patients N/A N/A N/A N/A Human N/A N/A 27374438 C6orf176-TV2 non-small cell lung cancer Expression The expression of C6orf176-TV1 or C6orf176-TV2 is down regulated in NSCLC and it is correlated with the grade of differentiation. It may act as a diagnosis indicator for NSCLC patients N/A N/A N/A N/A Human N/A N/A 27374438 MALAT1 pancreatic cancer Regulation Long Noncoding RNA MALAT1 Promotes Aggressive Pancreatic Cancer Proliferation and Metastasis via the Stimulation of Autophagy. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27371730 PVT1 renal carcinoma Expression Our study discloses the role of PVT1 as a novel prognostic factor and as a molecular target for novel therapeutic interventions in renal carcinoma. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 27366943 H19 glioma Regulation "H19 plays an important role in the development of TMZ resistance, and may represent a novel therapeutic target for TMZ-resistant gliomas." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27366087 TUG1 glioma Regulation This study revealed a new TUG1/miR-26a/PTEN regulatory mechanism and provided a further understanding of the tumor-suppressive role of TUG1 in glioma development. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27363339 H19 bladder cancer Regulation "LncRNA H19 and circRNA MYLK could bind competitively with miRNA-29a-3p increasing target gene DNMT3B, VEGFA and ITGB1 expressions." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27363013 RP11-359E19.2 bladder cancer Regulation "The nearby genes pattern displayed that overexpressing ADAM2 and C8orf4 are cis-regulated by lncRNA RP11-359E19.2, involving in progression of bladder cancer." chr8 40114651 40127468 + Human AC022733.1 ENST00000521257 27363013 BC041488 bladder cancer Regulation LncRNA BC041488 could trans-regulate CDK1 mRNA expression through SRF transcription factor. N/A N/A N/A N/A Human N/A N/A 27363013 MALAT1 pulmonary arterial hypertension Regulation Functional polymorphism of lncRNA MALAT1 contributes to pulmonary arterial hypertension susceptibility in Chinese people. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27362960 TUG1 hepatoblastoma Regulation Targeting long non-coding RNA-TUG1 inhibits tumor growth and angiogenesis in hepatoblastoma. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27362796 SOX2-OT colorectal cancer Expression Enhanced expression of long non-coding RNA Sox2ot promoted cell proliferation and motility in colorectal cancer. chr3 181056680 181742228 + Human NCRNA00043; SOX2OT NR_075089 27353770 MALAT1 tongue squamous cell carcinoma Expression Upregulated MALAT1 in TSCC promoted EMT and inhibited cell apoptosis by modulating Wnt/β-catenin signaling pathway. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27353727 LINC00052 hepatocellular carcinoma Regulation LINC00052 regulates the expression of NTRK3 by miR-128 and miR-485-3p to strengthen HCC cells invasion and migration. chr15 87576929 87579686 + Human NCRNA00052; TMEM83 NR_026869 27351280 NEAT1 non-small cell lung cancer Regulation Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27351135 HOTTIP osteosarcoma Expression Overexpression of long non-coding RNA HOTTIP increases chemoresistance of osteosarcoma cell by activating the Wnt/β-catenin pathway. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 27347346 HOTTIP non-small cell lung cancer Locus "HOTTIP functions as an oncogene by regulating HOXA13 in NSCLC, which may represent a new biomarker and a potential therapeutic target for NSCLC intervention." chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 27347311 CCAT2 hepatocellular carcinoma Locus "Long non-coding RNA CCAT2 functions as an oncogene in hepatocellular carcinoma, regulating cellular proliferation, migration and apoptosis." chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 27347113 MINCR gallbladder cancer Expression MINCR could potentially be a therapeutic target as well as a prognostic marker in GBC. chr8 143280155 143281700 - Human LINC01604 NR_120682 27345740 TUG1 glioblastoma Regulation "TUG1 enhances tumor-induced angiogenesis and VEGF expression through inhibiting miR 299. Also, the inhibition of TUG1 could provide a novel therapeutic target for glioblastoma treatment." chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27345398 SOCS2-AS1 prostate cancer Regulation SOCS2-AS1 plays an important role in the development of castration-resistant prostate cancer by repressing apoptosis. chr12 93565628 93571398 - Human N/A NR_038263 27342777 TUG1 B-cell neoplasms Locus TUG1 is a recently identified oncogenic lncRNA chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27339553 TUG1 oesophageal squamous cell carcinoma Locus TUG1 is a recently identified oncogenic lncRNA chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27339553 TUG1 bladder cancer Locus TUG1 is a recently identified oncogenic lncRNA chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27339553 TUG1 hepatocellular carcinoma Locus TUG1 is a recently identified oncogenic lncRNA chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27339553 TUG1 osteosarcoma Locus TUG1 is a recently identified oncogenic lncRNA chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27339553 LOC100130476 esophageal squamous cell carcinoma Expression LOC100130476 is down-regulated in ESCC at least partly by hypermethylation of CpG sites in exon 1 and its hypermethylation may have prognostic implications for ESCC patients. chr6 137823669 137868233 - Human N/A NR_049793 27338851 BACE1-AS Alzheimer's disease Expression BACE1-AS levels are up-regulated in AD brains where BACE1-AS acts by stabilizing BACE1 mRNA thereby increasing BACE1 protein content and Aβ42 formation chr11 117291346 117292170 + Human BACE1-AS1; BACE1AS; NCRNA00177 NR_037803 27338628 NEAT1_2 amyotrophic lateral sclerosis Regulation In Frontotemporal dementia and Amyotrophic lateral sclerosis the lncRNAs NEAT1_2 and MALAT1 co-localize at nuclear paraspeckles with TDP-43 and FUS proteins and their binding to TDP-43 is markedly increased in affected brains. chr11 65423638 65423742 + Human NEAT1_2 ENST00000620525 27338628 MALAT1 amyotrophic lateral sclerosis Regulation In Frontotemporal dementia and Amyotrophic lateral sclerosis the lncRNAs NEAT1_2 and MALAT1 co-localize at nuclear paraspeckles with TDP-43 and FUS proteins and their binding to TDP-43 is markedly increased in affected brains. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27338628 UCHL1-AS1 Parkinson's disease Regulation In Parkinson's Disease the lncRNA UCHL1-AS1 acts by directly promoting translation of UCHL1 protein leading to perturbation of the ubiquitin-proteasome system chr4 41220074 41256727 - Human N/A NR_102709 27338628 HTT-AS Huntington's disease Expression "Different lncRNAs, such as HTT-AS, BDNF-AS and HAR1, were found to be dysregulated in their expression also in Huntington's Disease." chr4 3063246 3074514 - Human HTT-AS1; HTTAS NR_045414 27338628 BDNF-AS Huntington's disease Expression "Different lncRNAs, such as HTT-AS, BDNF-AS and HAR1, were found to be dysregulated in their expression also in Huntington's Disease." chr11 27506852 27698171 + Human ANTI-BDNF; BDNF1; BDNFOS; NCRNA00049; BDNF-AS NR_033314 27338628 HAR1 Huntington's disease Expression "Different lncRNAs, such as HTT-AS, BDNF-AS and HAR1, were found to be dysregulated in their expression also in Huntington's Disease." N/A N/A N/A N/A Human N/A N/A 27338628 FMR1-AS1 fragile X syndrome Expression "It is expressed in peripheral blood leukocytes, suggesting these lncRNAs may represent biomarkers for FXS/FXTAS early detection and therapy." chrX 147909431 147911817 - Human ASFMR1; FMR1-AS; FMR1AS; FMR4 NR_024499 27338628 FMR6 fragile X syndrome Expression "It is expressed in peripheral blood leukocytes, suggesting these lncRNAs may represent biomarkers for FXS/FXTAS early detection and therapy." N/A N/A N/A N/A Human N/A N/A 27338628 SCAANT1-AS spinocerebellar ataxia N/A It plays a important role in spinocerebellar ataxia 7 and 8 N/A N/A N/A N/A Human N/A N/A 27338628 ATXN8OS spinocerebellar ataxia N/A It plays a important role in spinocerebellar ataxia 7 and 8 chr13 70107213 70139753 + Human KLHL1AS; NCRNA00003; SCA8 NR_002717 27338628 CAT104 breast cancer Expression "Further study showed the three-lncRNA signature was not only pervasive in different breast cancer stages, subtypes and age groups, but also provides more accurate prognostic information than some widely known biomarkers." N/A N/A N/A N/A Human N/A N/A 27338266 LINC01234 breast cancer Expression "Further study showed the three-lncRNA signature was not only pervasive in different breast cancer stages, subtypes and age groups, but also provides more accurate prognostic information than some widely known biomarkers." chr12 113744577 113773683 - Human LCAL84; onco-lncRNA-32 NR_110026 27338266 STXBP5-AS1 breast cancer Expression "Further study showed the three-lncRNA signature was not only pervasive in different breast cancer stages, subtypes and age groups, but also provides more accurate prognostic information than some widely known biomarkers." chr6 146841388 147204614 - Human N/A NR_034115 27338266 MEG3 lung adenocarcinoma Regulation MEG3 may be underlying therapeutic targets for LUAD functioning as ceRNAs for regulation of miRNA-mRNA. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 27338053 MIAT lung adenocarcinoma Regulation MIAT may be underlying therapeutic targets for LUAD functioning as ceRNAs for regulation of miRNA-mRNA. chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 27338053 LINC00115 lung adenocarcinoma Regulation LINC00115 may be underlying therapeutic targets for LUAD functioning as ceRNAs for regulation of miRNA-mRNA. chr1 826206 827522 - Human NCRNA00115 NR_024321 27338053 GAS5 non-small cell lung cancer Expression GAS5 downregulation is associated with cisplatin resistance in NSCLC. GAS5 can inhibit autophagy and therefore enhance cisplatin sensitivity in NSCLC cells. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 27338051 HMlincRNA717 pancreatic cancer Expression HMlincRNA717 could be a potential prognostic biomarker for pancreatic cancer progression. N/A N/A N/A N/A Human N/A N/A 27338046 MAPT-AS1 Parkinson's disease Expression "Increased MAPT expression could be associated with disease state, but not with PD neuropathology severity." chr17 45843356 45895513 - Human N/A NR_024559 27336847 UCA1 osteosarcoma Expression Overexpression of lncRNA UCA1 promotes osteosarcoma progression and correlates with poor prognosis. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27335776 TUG1 esophageal squamous cell carcinoma Expression High TUG1 expression is associated with chemotherapy resistance and poor prognosis in esophageal squamous cell carcinoma. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27329359 HAGLR bladder cancer Expression High expression of HOXD-AS1 may be involved in the bladder cancer carcinogenesis through inhibiting the phenotypes and activating endogenous cancer-related molecular pathways. chr2 176173189 176188958 - Human HOXD-AS1; Mdgt NR_110460 27328915 HOTAIR cervical cancer Regulation The long non-coding RNA HOTAIR increases tumour growth and invasion in cervical cancer by targeting the Notch pathway. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27323817 TUG1 renal cell carcinoma Regulation "Downregulation of the long noncoding RNA TUG1 inhibits the proliferation, migration, invasion and promotes apoptosis of renal cell carcinoma." chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27323757 CAR10 lung cancer Expression "These results demonstrate the role of CAR10 in environmental lung carcinogenesis, and CAR10-YB-1 represents a potential therapeutic target." N/A N/A N/A N/A Human N/A N/A 27322209 HULC gastric cancer Expression Long non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer. chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 27322075 CDKN2B-AS1 ischemic heart failure Expression "CDKN2B-AS1/ANRIL, HOTAIR and LOC285194/TUSC7 showed similar modulation in peripheral blood mononuclear cells and heart tissue, suggesting a potential role as disease biomarkers." chr9 21994778 22121097 + Human CDKN2B-AS1 ENST00000428597 27317124 HOTAIR ischemic heart failure Expression "CDKN2B-AS1/ANRIL, HOTAIR and LOC285194/TUSC7 showed similar modulation in peripheral blood mononuclear cells and heart tissue, suggesting a potential role as disease biomarkers." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27317124 TUSC7 ischemic heart failure Expression "CDKN2B-AS1/ANRIL, HOTAIR and LOC285194/TUSC7 showed similar modulation in peripheral blood mononuclear cells and heart tissue, suggesting a potential role as disease biomarkers." chr3 116709788 116717040 + Human LINC00902; LSAMP-AS1; LSAMP-AS3; LSAMPAS3; NCRNA00295 NR_015391 27317124 CDKN2B-AS1 colorectal cancer Regulation "ANRIL is associated with the survival rate of patients with colorectal cancer,and affects cell migration and invasion in vitro." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 27314206 MALAT1 ovarian cancer Locus "The findings define a major oncogenic role for MALAT1, which may offer an attractive novel target for therapeutic intervention in ovarian cancer." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27313681 LINC-ROR nasopharyngeal carcinoma Regulation "Long non-coding RNA ROR promotes proliferation, migration and chemoresistance of nasopharyngeal carcinoma." chr18 57054571 57072119 - Human ROR; lincRNA-RoR NR_048536 27311700 CDKN2B-AS1 non-small cell lung cancer Regulation Long noncoding RNA ANRIL could be transactivated by cMyc and promote tumor progression of non-small-cell lung cancer. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 27307748 HOTAIR hepatocellular carcinoma Expression "HOTAIR, overexpressed in HCC and associated with tumor size, could activate autophagy by increasing ATG3 and ATG7 expression, promoting HCC cell proliferation." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27301338 LINC00342 non-small cell lung cancer Expression LINC00342 which is significantly up-regulated in NSCLC and could be a prognostic biomarker. chr2 95807052 95826981 - Human NCRNA00342 NR_103734 27299310 HOTAIR colon cancer Regulation "HOTAIR plays an important role in the tumorigenesis, development and metastasis of colon cancer. HOTAIR may act as an oncogene and represents a new molecular target for the treatment of colon cancer." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27298568 MALAT1 lung adenocarcinoma Locus LncRNA MALAT1 exerts oncogenic functions in lung adenocarcinoma by targeting miR-204. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27294002 CDKN2B-AS1 colorectal cancer Expression Downregulation of long non-coding RNA ANRIL suppresses lymphangiogenesis and lymphatic metastasis in colorectal cancer. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 27286457 HULC hepatocellular carcinoma Regulation LncRNA HULC enhances epithelial-mesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR 200a-3p/ZEB1 signaling pathway. chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 27285757 CCAT2 ovarian cancer Expression The long non-coding RNA CCAT2 is up-regulated in ovarian cancer and associated with poor prognosis. chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 27283598 SPRY4-IT1 hepatocellular carcinoma Regulation SPRY4-IT1 plays a critical role in HCC tumorigenesis and may be considered as a potential diagnostic indicator in HCC. chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 27278245 HOTAIR glioma Expression "Downregulation of HOTAIR expression effectively promoted the expression of PDCD4, thereby inhibiting the proliferation, invasion and in vivo tumorigenicity of human GSCs." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27277755 BCYRN1 breast cancer Expression BC200 may serve as a prognostic marker and possible target for attenuating deregulated cell proliferation in estrogen dependent breast cancer. chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 27277684 LINC00628 gastric cancer Regulation "LINC00628 functions as a GC suppressor through suppressing proliferation, migration and colony formation of cancer cells." chr1 204368430 204369719 - Human N/A NR_027022 27272474 PVT1 cervical cancer Expression "PVT1 is not only an important prognostic marker, but also a potential therapy target for cervical cancer." chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 27272214 NEAT1 non-small cell lung cancer Regulation NEAT1 may act as a competing endogenous lncRNA to upregulate EGCG-induced CTR1 by sponging hsa-mir 98-5p in NSCLC. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27270317 RP11-838N2.4 glioblastoma N/A Characterization of lncRNA RP11-838N2.4 could contribute to strategies for enhancing the efficacy of TMZ. chr18 3466250 3478978 + Human GAPLINC ENST00000578664 27270310 uc.167 ventricular septal defects Regulation uc.167 contributes to the development potential of VSD and may constitute a potential therapeutic target in this disease. N/A N/A N/A N/A Human N/A N/A 27268728 ATB glioma Regulation Long non-coding RNA ATB promotes glioma malignancy by negatively regulating miR-200a. N/A N/A N/A N/A Human N/A N/A 27267902 UCA1 esophageal squamous cell carcinoma Regulation LncRNA UCA1 inhibits esophageal squamous-cell carcinoma growth by regulating the Wnt signaling pathway. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27267823 UNMIBC bladder cancer Regulation LncRNA-UNMIBC can facilitate tumor growth and may act as a negative prognostic factor of recurrence. N/A N/A N/A N/A Human N/A N/A 27267320 HIF1A-AS2 glioblastoma Regulation The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches. chr14 61747039 61749089 - Human 3'aHIF-1A; aHIF NR_045406 27264189 TUG1 gastric cancer Expression LncRNA-TUG1 shows an up-regulated expression in GC tissue and that bears a correlation with clinicopathological features of malignant tumor. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27261864 MDC1-AS1 glioma Expression MDC1-AS may serve as a potential biomarker and therapeutic target for glioma. chr6 30703067 30713184 + Human MDC1-AS NR_133647 27261595 AFAP1-AS1 colorectal cancer Expression Overexpression of lncRNA AFAP1-AS1 correlates with poor prognosis and promotes tumorigenesis in colorectal cancer. chr4 7754090 7778928 + Human AFAP1-AS; AFAP1AS NR_026892 27261589 LINC00673 pancreatic ductal adenocarcinoma Regulation The PDAC risk variant of LINC00673 is targeted by miR 1231 to promote PDAC growth. chr17 72403322 72592804 - Human HI-LNC75; HILNC75; LUCAIR1; SLNCR; SLNCR1 NR_036488 27260162 MALAT1 gastric cancer Regulation Overexpressed MALAT1 promotes invasion and metastasis of gastric cancer cells via increasing EGFL7 expression. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27259812 GAPLINC colorectal cancer Expression "The increased expression of GAPLINC was found to be positively correlated with larger tumor size, advanced tumor stage (T stage), advanced node stage (N stage), increased death, and shorter survival of patients with CRC by in situ hybridization analysis." chr18 3466250 3478978 + Human LINC01540 NR_110428 27259250 HULC osteosarcoma Expression "Elevated HULC expression was associated with poor clinical outcomes among the OS patients, which suggests that HULC could be a potential prognostic biomarker in OS." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 27253450 SPRY4-IT1 esophageal squamous cell carcinoma Regulation Upregulation of long noncoding RNA SPRY4-IT1 promotes metastasis of esophageal squamous cell carcinoma via induction of epithelial mesenchymal transition. chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 27250657 CASC8 lung cancer Expression "LncRNA CASC8 rs10505477 could serve as a possible risk marker for diagnosing lung cancer, and could be used to forecast the response and toxicity of platinum based treatment in lung cancer patients." N/A N/A N/A N/A Human N/A N/A 27249003 CPS1-IT1 hepatocellular carcinoma Regulation LncRNA CPS1-IT1 acts as a tumor suppressor in HCC by reducing HIF-1α activation and suppressing EMT. chr2 210617571 210619876 + Human CPS1-IT; CPS1IT; CPS1IT1; PRO0132 NR_002763 27248828 XIST breast cancer Regulation Our findings elucidate the tumor suppressor role of Xist in breast cancer and provide the molecular basis of Xist in downregulating AKT activation. chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 27248326 H19 esophageal squamous cell carcinoma Locus "H19 acts as an oncogene and promotes ESCC cell proliferation and metastasis, which may infer H19 as a marker of poor prognosis and, thus, a potential therapeutic target for treating ESCC patients." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27247022 ZFAS1 gastric cancer Regulation Long noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression. chr20 49278178 49289260 + Human C20orf199; HSUP1; HSUP2; NCRNA00275; ZNFX1-AS1 NR_036658 27246976 HOTAIR gastric cancer Locus It has been demonstrated having oncogene activities chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27246953 HULC gastric cancer Locus It has been demonstrated having oncogene activities chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 27246953 CYTOR gastric cancer Locus It has been demonstrated having oncogene activities chr2 87455455 87521518 + Human C2orf59; LINC00152; NCRNA00152 NR_024204 27246953 MALAT2 gastric cancer Locus It has been demonstrated having oncogene activities N/A N/A N/A N/A Human N/A N/A 27246953 H19 gastric cancer Locus It has been demonstrated having oncogene activities chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27246953 GHET1 gastric cancer Locus It has been demonstrated having oncogene activities chr7 148987527 148989429 + Human lncRNA-GHET1 NR_130107 27246953 GACAT3 gastric cancer Locus It has been demonstrated having oncogene activities chr2 16050427 16085689 + Human LINC01458; lncRNA-AC130710 NR_126559 27246953 LEIGC gastric cancer Regulation It has been thought as tumor suppressor N/A N/A N/A N/A Human N/A N/A 27246953 GAS5 gastric cancer Regulation It has been thought as tumor suppressor chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 27246953 FER1L4 gastric cancer Regulation It has been thought as tumor suppressor chr20 35558737 35607562 - Human FER1L4 ENST00000615531 27246953 lnc-β-Catm hepatocellular carcinoma Expression "The expression of lnc-β-Catm, EZH2 and Wnt-β-catenin targets is positively correlated with cancer severity and prognosis of people with HCC." N/A N/A N/A N/A Human N/A N/A 27239797 SPRY4-IT1 melanoma Expression PRY4-IT1 may be a potential prognostic marker and a potential therapeutic target. chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 27239436 PVT1 cervical cancer Regulation The lncRNA PVT1 Contributes to the Cervical Cancer Phenotype and Associates with Poor Patient Prognosis. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 27232880 HOTAIR cervical cancer N/A Analysis of the association of HOTAIR single nucleotide polymorphism (rs920778) and risk of cervical cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27229487 APOC1P1-3 breast cancer Expression Overexpression of APOC1P1-3 can inhibit breast cancer apoptosis. N/A N/A N/A N/A Human N/A N/A 27228351 MALAT1 ovarian cancer Regulation "MALAT-1 promotes the growth and migration of ovarian cancer cells, suggesting that MALAT-1 may be an important contributor to ovarian cancer development." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27227769 PAX8-AS1 cervical cancer Expression Expression quantitative trait loci in long non-coding RNA PAX8-AS1 are associated with decreased risk of cervical cancer. chr2 113235527 113267023 + Human N/A NR_015377 27225188 lnc-CC3 cervical cancer Expression "Overexpression of lnc-CC3 promoted migration and invasion by SiHa cervical cancer cells in vitro and in vivo, increased Slug expression, and reduced the expression of the epithelial cell" N/A N/A N/A N/A Human N/A N/A 27223436 AK021595 lung cancer Expression It may be candidate prognostic biomarkers for lung cancer patients. N/A N/A N/A N/A Human N/A N/A 27222340 BC030759 lung cancer Expression It may be candidate prognostic biomarkers for lung cancer patients. N/A N/A N/A N/A Human N/A N/A 27222340 AK000053 lung cancer Expression It may be candidate prognostic biomarkers for lung cancer patients. N/A N/A N/A N/A Human N/A N/A 27222340 AK124307 lung cancer Expression It may be candidate prognostic biomarkers for lung cancer patients. N/A N/A N/A N/A Human N/A N/A 27222340 BC020384 lung cancer Expression It may be candidate prognostic biomarkers for lung cancer patients. N/A N/A N/A N/A Human N/A N/A 27222340 AK022024 lung cancer Expression It may be candidate prognostic biomarkers for lung cancer patients. N/A N/A N/A N/A Human N/A N/A 27222340 CR615992 lung cancer Expression It may be candidate prognostic biomarkers for lung cancer patients. N/A N/A N/A N/A Human N/A N/A 27222340 AF085995 lung cancer Expression It may be candidate prognostic biomarkers for lung cancer patients. N/A N/A N/A N/A Human N/A N/A 27222340 CASC2 renal cell carcinoma Expression CASC2 may be considered a novel target for the diagnosis and treatment of RCC. chr10 118046821 118210153 + Human C10orf5 NR_026939 27222255 NEAT1 Huntington's disease Expression NEAT1 upregulation in HD contributes to the neuroprotective mechanism against neuronal injury rather than the pathological process underlying neurodegeneration in HD. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27221610 CCAT2 oral squamous cell carcinoma Locus Up-regulation of CCAT2 expression in tumor tissue might act as an oncogene and promote the development of OSCC. chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 27220388 ZNF582-AS1 colorectal cancer Regulation ZNF582-AS1 may be a novel tumor-suppressive lncRNA. chr19 56393676 56399175 + Human N/A NR_037161 27215978 UCA1 hepatocellular carcinoma Expression The possible role of lncRNA-UCA1 is a promising diagnostic and a prognostic marker as well as potential therapeutic target in HCC. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27215316 PAUPAR uveal melanoma Expression The role of this lncRNA is a novel therapeutic target in cancer prevention and treatment. chr11 31826567 31829303 + Human N/A NR_117094 27214741 LINC00673 pancreatic cancer Regulation "A long intergenic noncoding RNA (lincRNA), LINC00673, is a potential tumor suppressor whose germline variation is associated with pancreatic cancer risk." chr17 72403322 72592804 - Human HI-LNC75; HILNC75; LUCAIR1; SLNCR; SLNCR1 NR_036488 27213290 CCAT1 lung cancer Regulation This epigenetic silencing of miR-218 by CCAT1 induces an altered cell cycle transition through BMI1 and provides a new mechanism for CSE-induced lung carcinogenesis. chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 27212446 SNHG15 hepatocellular carcinoma Expression LncRNA SNHG15 may serve as an efficient clinical biomarker and a therapeutic target for HCC patients. chr7 44983028 44986660 - Human C7orf40; Linc-Myo1g; MYO1GUT NR_003697 27212162 LINC00673 melanoma Regulation The lncRNA SLNCR1 Mediates Melanoma Invasion through a Conserved SRA1-like Region. chr17 72403322 72592804 - Human HI-LNC75; HILNC75; LUCAIR1; SLNCR; SLNCR1 NR_036488 27210747 PANDAR bladder cancer Expression Up-regulation of long non-coding RNA PANDAR is associated with poor prognosis and promotes tumorigenesis in bladder cancer. chr6 36673621 36675126 - Human PANDA NR_109836 27206339 LUCAT1 non-small cell lung cancer N/A Long noncoding RNA LUCAT1 is associated with poor prognosis in human non-small cell lung cancer and affects cell proliferation via regulating p21 and p57 expression. chr5 91302986 91314402 - Human SCAL1 NR_103548 27198302 CASC2 colorectal cancer Regulation CASC2 as a ceRNA plays an important role in CRC pathogenesis and may serve as a potential target for cancer diagnosis and treatment. chr10 118046821 118210153 + Human C10orf5 NR_026939 27198161 BCAR4 colorectal cancer Expression "One lncRNA, BCAR4, could be potential candidates to detect colorectal cancer." chr16 11819830 11828832 - Human N/A NR_024050 27197301 MALAT1 breast cancer Regulation The Ribonucleic Complex HuR-MALAT1 Represses CD133 Expression and Suppresses Epithelial-Mesenchymal Transition in Breast Cancer. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27197265 AGAP2-AS1 non-small cell lung cancer Locus AGAP2-AS1 may act as an oncogene by repressing tumor-suppressor LATS2 and KLF2 transcription. chr12 57726240 57728356 + Human PUNISHER NR_027032 27195672 SOX2-OT retinal neurodegeneration Locus Sox2OT knockdown plays a neuroprotective role in diabetes-related retinal neurodegeneration in vivo. chr3 181056680 181742228 + Human NCRNA00043; SOX2OT NR_075089 27193103 LOC100130476 gastric cardia adenocarcinoma Regulation Aberrant methylation of LOC100130476 in peripheral white blood cells and GCA tissues may be used as a potential valuable biomarker in GCA diagnosis and prognosis. chr6 137823669 137868233 - Human N/A NR_049793 27189370 LINC00426 primary Sjögren's syndrome Expression It was significantly upregulated in pSS chr13 30340266 30373914 - Human N/A NR_024464 27188286 ENST00000455309 primary Sjögren's syndrome Expression It was significantly upregulated in pSS N/A N/A N/A N/A Human N/A N/A 27188286 n336161 primary Sjögren's syndrome Expression It was significantly upregulated in pSS N/A N/A N/A N/A Human N/A N/A 27188286 NR_002712 primary Sjögren's syndrome Expression It was significantly upregulated in pSS N/A N/A N/A N/A Human N/A N/A 27188286 LINC02384 primary Sjögren's syndrome Expression It was significantly upregulated in pSS chr12 68431842 68451484 - Human N/A NR_120458 27188286 Lnc-UTS2D-1:1 primary Sjögren's syndrome Expression It was significantly upregulated in pSS N/A N/A N/A N/A Human N/A N/A 27188286 n340599 primary Sjögren's syndrome Expression It was significantly upregulated in pSS N/A N/A N/A N/A Human N/A N/A 27188286 TCONS_l2_00014794 primary Sjögren's syndrome Expression It was significantly upregulated in pSS N/A N/A N/A N/A Human N/A N/A 27188286 CYTOR renal cell carcinoma Expression Linc00152 is a novel molecule involved in ccRCC progression as well as a potential prognostic biomarker and therapeutic target. chr2 87455455 87521518 + Human C2orf59; LINC00152; NCRNA00152 NR_024204 27186403 HOTAIR lung cancer Regulation MiR-326 regulates cell proliferation and migration in lung cancer by targeting Phox2a and is regulated by HOTAIR. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27186394 H19 osteosarcoma Regulation MiR-141 modulates osteoblastic cell proliferation by regulating the target gene of lncRNA H19 and lncRNA H19-derived miR-675. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27186302 lnc-ZNF354A-1 ankylosing spondylitis N/A It may be involved in the abnormal osteogenic differentiation of ASMSC. N/A N/A N/A N/A Human N/A N/A 27182066 lnc-LIN54-1 ankylosing spondylitis N/A It may be involved in the abnormal osteogenic differentiation of ASMSC. N/A N/A N/A N/A Human N/A N/A 27182066 lnc-FRG2C-3 ankylosing spondylitis N/A It may be involved in the abnormal osteogenic differentiation of ASMSC. N/A N/A N/A N/A Human N/A N/A 27182066 lnc-USP50-2 ankylosing spondylitis N/A It may be involved in the abnormal osteogenic differentiation of ASMSC. N/A N/A N/A N/A Human N/A N/A 27182066 ATB prostate cancer Regulation Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma. N/A N/A N/A N/A Human N/A N/A 27176634 MALAT1 breast cancer Expression MALAT1 is a predictive biomarker and a therapeutic target. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27172249 RMEL3 melanoma Regulation "RMEL3 is required for MAPK and PI3K signaling, and its knockdown decrease BRAFV600E melanoma cell survival and proliferation." N/A N/A N/A N/A Human N/A N/A 27167340 UCA1 liver cancer Regulation Double mutant P53 (N340Q/L344R) promotes hepatocarcinogenesis through upregulation of Pim1 mediated by PKM2 and LncRNA CUDR. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27167190 HOTAIR ovarian cancer Expression HOTAIR variants could be a useful biomarker for the predisposition to EOC and for the early diagnosis of the disease. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27166268 ZNRD1-AS1 lung cancer Locus "Strong evidence for LncRNA ZNRD1-AS1, and its functional Cis-eQTL locus contributing more to the susceptibility of lung cancer." N/A N/A N/A N/A Human N/A N/A 27166266 MEG3 breast cancer Expression "Downregulated long non-coding RNA MEG3 in breast cancer regulates proliferation, migration and invasion by depending on p53's transcriptional activity." chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 27166155 SAMMSON melanoma N/A Targeting the lncRNA SAMMSON Reveals Metabolic Vulnerability in Melanoma. chr3 69999744 70015301 + Human LINC01212 NR_110000 27165740 HOTAIR colorectal cancer Regulation "The role of the HOTAIR in CRC progression is associated with the acquisition of stemness, with the potential mechanism of gene silencing by binding to PRC2 and LSD1" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27165481 MALAT1 colorectal cancer Expression "The down-regulation of MALAT1 by resveratrol could decrease the nuclear localization of β‐catenin and attenuate Wnt/β‐catenin signaling, thereby inhibiting CRC invasion and metastasis " chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27165481 LOC285194 colorectal cancer Regulation LOC285194 was shown to be a potential inhibitor and the signal pathway should be further characterized. N/A N/A N/A N/A Human N/A N/A 27165481 uc.388 colorectal cancer Expression uc.388 was shown to be a potential inhibitor and the signal pathway should be further characterized . N/A N/A N/A N/A Human N/A N/A 27165481 MEG3 testicular germ cell tumor Expression Re-expression of Meg3 may be an attractive strategy for TGCT therapy. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 27158395 TUSC7 non-small cell lung cancer Expression "TUSC7 was a potential biomarker for NSCLC prognosis, and the dysregulation of TUSC7 may play an important role in the NSCLC progression." chr3 116709788 116717040 + Human LINC00902; LSAMP-AS1; LSAMP-AS3; LSAMPAS3; NCRNA00295 NR_015391 27158360 uc.338 hepatocellular carcinoma Locus The oncogenic activity of uc.338 is partially due to its repression of p21. uc.338 may be a potential target for HCC therapy. N/A N/A N/A N/A Human N/A N/A 27154519 SBF2-AS1 non-small cell lung cancer Expression SBF2-AS1 may serve as a novel biomarker and potential therapeutic target for NSCLC patients. chr11 9758293 9811319 + Human N/A NR_036485 27154193 LOC100507661 thyroid cancer Expression LOC100507661 expression is elevated in human thyroid cancer and may play a critical role in thyroid carcinogenesis. N/A N/A N/A N/A Human N/A N/A 27151833 AL049437 Parkinson's disease N/A LncRNA AL049437 likely contributed to the risk of PD N/A N/A N/A N/A Human N/A N/A 27151187 AK021630 Parkinson's disease Regulation LncRNA AK021630 likely inhibited the occurrence of PD N/A N/A N/A N/A Human N/A N/A 27151187 NEAT1 breast cancer N/A NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27147820 GClnc1 gastric cancer Locus GClnc1 is an oncogenic lncRNA in human gastric cancer. N/A N/A N/A N/A Human N/A N/A 27147598 HOTAIRM1 acute promyelocytic leukemia Expression "The reduced PU.1 expression, rather than PML-RARα itself, results in the low expression of HOTAIRM1 in APL cells" chr7 27096094 27100258 + Human HOXA-AS1; HOXA1-AS1; NCRNA00179 NR_038367 27146823 HOTTIP gastric cancer Regulation Oncogenic function of the homeobox A13-long noncoding RNA HOTTIP-insulin growth factor-binding protein 3 axis in human gastric cancer. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 27144338 BCYRN1 esophageal squamous cell carcinoma Expression High expression of BC200 reflects poor prognosis and could serve as a novel predictive marker for ESCC patients who received radical resection. chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 27143917 LINC00473 non-small cell lung cancer Expression "LINC00473 expression potentially serves as a robust biomarker for tumor LKB1 functional status that can be integrated into clinical trials for patient selection and treatment evaluation, and implicates LINC00473 as a therapeutic target for LKB1-inactivated NSCLC." chr6 165924048 165988039 - Human C6orf176; bA142J11.1 NR_026860 27140397 AK033210 bronchopulmonary dysplasia Expression "A downregulated lncRNA, namely AK033210, associated with tenascin C may be involved in the pathogenesis of BPD." N/A N/A N/A N/A Human N/A N/A 27137150 MALAT1 glioma Regulation The current study indicated a promoting role of MALAT1 in the development of glioma cell. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27134488 CCAT1 gastric cancer Expression "Enforced expression of CCAT1 exerts potent tumorigenic effects by promoting cell proliferation, invasion and migration." chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 27134049 CCAT1 colorectal cancer Expression "Enforced expression of CCAT1 exerts potent tumorigenic effects by promoting cell proliferation, invasion and migration." chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 27134049 CCAT1 hepatocellular carcinoma Expression "Enforced expression of CCAT1 exerts potent tumorigenic effects by promoting cell proliferation, invasion and migration." chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 27134049 SNHG1 hepatocellular carcinoma Expression SNHG1 may be considered as a prognostic biomarker and therapeutic target for HCC. chr11 62851988 62855888 - Human LINC00057; NCRNA00057; U22HG; UHG; lncRNA16 NR_003098 27133041 GHET1 colorectal cancer Regulation Knockdown of Long Noncoding RNA GHET1 Inhibits Cell Proliferation and Invasion of Colorectal Cancer. chr7 148987527 148989429 + Human lncRNA-GHET1 NR_130107 27131316 LOC572558 bladder cancer Expression It may serve as a promising new diagnostic marker and therapeutic target in bladder cancer. N/A N/A N/A N/A Human N/A N/A 27130667 HOTAIR diffuse large B-cell lymphoma Expression "HOTAIR may be regarded as a novel indicator of poor prognosis, and may serve as a potential target for gene therapy in the treatment of DLBCL." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27122348 CDKN2B-AS1 gastric cancer Regulation "Knockdown of lncRNA ANRIL in gastric cancer cells inhibits the development of MDR, suggesting an efficacious target for reversing MDR in gastric cancer therapy." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 27121324 uc.48+ type 2 diabetes mellitus Regulation LncRNA uc.48+ siRNA improved diabetic sympathetic neuropathy in type 2 diabetic rats through regulating the expression of P2X7 and ERK signaling in SCG. N/A N/A N/A N/A Mouse N/A N/A 27118262 lncARSR renal cell carcinoma Expression LncARSR may serve as a predictor and a potential therapeutic target for sunitinib resistance. N/A N/A N/A N/A Human N/A N/A 27117758 HOTAIR breast cancer Expression Plasma HOTAIR may serve as a potential biomarker for breast cancer diagnosis. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27113175 LINP1 breast cancer Regulation "Blocking LINP1, which is regulated by p53 and epidermal growth factor receptor (EGFR) signaling, increases the sensitivity of the tumor-cell response to radiotherapy in breast cancer." chr10 6737382 6738939 - Human N/A NR_138480 27111890 HOTTIP gastric cancer Regulation HOTTIP and HOXA13 play important roles in gastric cancer progression and provide a new insight into therapeutic treatment for the disease. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 27108607 AB073614 glioma Expression Increased lncRNA AB073614 expression may be identified as a poor prognostic biomarker in gliomas. N/A N/A N/A N/A Human N/A N/A 27104549 AB073614 ovarian cancer Regulation LncRNA AB073614 characterized as a new candidate lncRNA promotes the development of ovarian cancer. N/A N/A N/A N/A Human N/A N/A 27104549 HOTTIP gastric cancer Expression Overexpression of long noncoding RNA HOTTIP promotes tumor invasion and predicts poor prognosis in gastric cancer. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 27103834 CDKN2B-AS1 breast cancer N/A It plays a important role in breast cancer. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 27102007 XIST hepatocellular carcinoma Regulation MicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST. chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 27100897 MIAT prostate cancer Expression Long noncoding RNAs can be exploited as new biomarkers and therapeutic targets for NEPC（neuroendocrine prostate cancer? chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 27096814 CDKN2B-AS1 ovarian cancer Regulation ANRIL promotes EOC（epithelial ovarian cancer?progression and is a potential prognostic biomarker. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 27095571 NEAT1 gastric cancer Regulation LncRNA NEAT1 plays an important role on gastric cancer tumorigenesis and progression and may act as a potential biomarker for therapeutic strategy and prognostic prediction. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27095450 H19 thyroid cancer Regulation Long noncoding RNA H19 competitively binds miR 17-5p to regulate YES1 expression in thyroid cancer. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27093644 H19 bladder cancer Mutation Genetic variants in lncRNA H19 are associated with the risk of bladder cancer in a Chinese population. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27091055 ATB keloid Regulation Knockdown of lncRNA-ATB suppresses autocrine secretion of TGF-β2 by targeting ZNF217 via miR-200c in keloid fibroblasts. N/A N/A N/A N/A Human N/A N/A 27090737 HNF1A-AS1 hepatocellular carcinoma Regulation "We identified HNF1A-AS1-miR-30b axis as a key regulator in hepatocarcinogenesis, which may be promising biomarkers and therapeutic targets in the future." chr12 120969838 120972292 - Human C12orf27; NCRNA00262 NR_024345 27084450 LOC101926975 Hirschsprung's disease Expression LOC101926975 can distinguish HSCR from the normal ones. N/A N/A N/A N/A Human N/A N/A 27076786 NEAT1 ovarian cancer Expression "LncRNA NEAT1, whose expression was collaboratively controlled by HuR and miR-124-3p, could regulate ovarian carcinogenesis and may serve as a potential target for antineoplastic therapies." chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27075229 RP4-799P18.3 ovarian cancer Expression The lncRNA signature may have important implications for outcome prediction and therapy decisions. chr1 234268583 234272500 - Human AL122008.4 ENST00000446433 27074572 PTPRD-AS1 ovarian cancer Expression The lncRNA signature may have important implications for outcome prediction and therapy decisions. chr9 8858018 8861727 + Human N/A NR_121600 27074572 RP11-57P19.1 ovarian cancer Expression The lncRNA signature may have important implications for outcome prediction and therapy decisions. chr15 94600014 94600821 + Human AC009432.1 ENST00000560391 27074572 RP11-307C12.11 ovarian cancer Expression The lncRNA signature may have important implications for outcome prediction and therapy decisions. chr1 155045191 155046118 - Human DCST1-AS1 ENST00000452962 27074572 RP11-254I22.1 ovarian cancer Expression The lncRNA signature may have important implications for outcome prediction and therapy decisions. chr5 96050115 96215519 + Human MIR583HG ENST00000507997 27074572 RP11-80H5.7 ovarian cancer Expression The lncRNA signature may have important implications for outcome prediction and therapy decisions. chr10 89694295 89697928 - Human AL157400.4 ENST00000455699 27074572 RP1-223E5.4 ovarian cancer Expression The lncRNA signature may have important implications for outcome prediction and therapy decisions. chr6 13614111 13615155 - Human AL441883.1 ENST00000566170 27074572 GACAT3 ovarian cancer Expression The lncRNA signature may have important implications for outcome prediction and therapy decisions. chr2 16050427 16085689 + Human LINC01458; lncRNA-AC130710 NR_126559 27074572 H19 gallbladder cancer Regulation Upregulation of H19 indicates a poor prognosis in gallbladder carcinoma and promotes epithelial-mesenchymal transition. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27073719 LINC-ROR colon cancer Expression Overexpression of lincRNA-ROR combined with depletion of miR-145 may exert crucial impact on colon cancer prognosis evaluation and treatment. chr18 57054571 57072119 - Human ROR; lincRNA-RoR NR_048536 27071407 HOTAIR colorectal cancer Expression The HOTAIR expression in CD133(+)CSCs could serve as a potential anti-cancer regimen to inhibit the invasiveness and metastasis of CRC CSCs. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27069543 FTX hepatocellular carcinoma Regulation lnc-FTX may act as a tumor suppressor in HCC through physically binding miR-374a and MCM2. chrX 74028136 74293574 - Human LINC00182; MIR374AHG; NCRNA00182 NR_028379 27065331 SNHG5 gastric cancer N/A SNHG5 may be a novel therapeutic target for the treatment of GC chr6 85677007 85678733 - Human C6orf160; LINC00044; NCRNA00044; U50HG; bA33E24.2 NR_003038 27065326 HOTTIP prostate cancer Regulation "Down-regulation of HOTTIP and HOXA13 was associated with cell growth and cell cycle, and exerts tumor-suppressive functions in the genesis and progression of prostate cancer, providing a potential attractive therapeutic approach for this malignancy." chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 27064878 HOTAIR temporomandibular joint osteoarthritis Regulation Upregulation of lncRNA HOTAIR contributes to IL-1β induced MMP overexpression and chondrocytes apoptosis in temporomandibular joint osteoarthritis. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27063559 LOC100287225 colorectal cancer Regulation LOC100287225 misregulation could be a potential target for gene therapy in colorectal cancer. N/A N/A N/A N/A Human N/A N/A 27062707 HOTTIP pancreatic ductal adenocarcinoma N/A It has been shown to influence the malignant behavior of PDAC cells. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 27060060 MALAT1 pancreatic ductal adenocarcinoma N/A It has been shown to influence the malignant behavior of PDAC cells. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27060060 CRNDE glioma Regulation CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis. chr16 54845189 54929189 - Human CRNDE ENST00000613942 27058823 SAMMSON melanoma Regulation SAMMSON is expressed in the majority of human melanomas and promotes cell growth and survival. chr3 69999744 70015301 + Human LINC01212 NR_110000 27056832 UCA1 gastric cancer N/A UCA1 might provide a new potential therapeutic target and stratagem for gastric cancer. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27056384 SNHG20 hepatocellular carcinoma Expression "SNHG20, up-regulated in patients with HCC, may serve as an independent prognostic predictor for HCC patients." chr17 77088643 77094986 + Human C17orf86; LINC00338; NCRNA00338; SCARNA16HG NR_027058 27053960 Z38 breast cancer Expression "The newly found lncRNA Z38, which plays important roles in breast cancer, may act as a candidate biomarker and therapeutic target in carcinomas." N/A N/A N/A N/A Human N/A N/A 27053956 BANCR osteosarcoma Regulation BANCR may act as a tumor promoter in osteosarcoma and could serve as a potential therapeutic target for this disease. chr9 69296681 69307056 - Human LINC00586 NR_047671 27051014 TMEVPG1 primary immune thrombocytopenia Regulation "TMEVPG1 could promote IFNG transcription, and IFNG over-expression negative feedback regulated on TMEVPG1 expression, which resulted in decreased TMEVPG1 in ITP patients." N/A N/A N/A N/A Human N/A N/A 27050808 PICSAR cutaneous squamous cell carcinoma Expression These results also identify PICSAR as a biomarker and putative therapeutic target in cSCC. chr21 44999208 45004727 - Human C21orf113; LINC00162; NCRNA00162; NLC1-C; NLC1C; PRED74 NR_024089 27049681 UCA1 colorectal cancer Locus UCA1 and CREB1 are potential new oncogenes and prognostic factors for CRC. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27046651 HULC diffuse large B-cell lymphoma Expression HULC could represent a novel indicator of poor prognosis and may be served as a potential target for the diagnosis and gene therapy of DLBCL. chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 27044827 CDKN2B-AS1 glaucoma N/A It plays a important role in Glaucoma chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 27043545 MALAT1 proliferative vitreoretinopathy N/A It plays a important role in proliferative vitreoretinopathy chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27043545 MIAT diabetic retinopathy N/A It plays a important role in diabeticretinopathy chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 27043545 BANCR retinoblastoma N/A It plays a important role in retinoblastoma chr9 69296681 69307056 - Human LINC00586 NR_047671 27043545 MEG3 retinoblastoma N/A It plays a important role in retinoblastoma chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 27043545 LINC-ROR unveal melanoma N/A It plays a important role in unveal melanoma chr18 57054571 57072119 - Human ROR; lincRNA-RoR NR_048536 27043545 CRNDE-h colorectal cancer Regulation "LncRNA CRNDE-h is associated with adverse clinical characteristics and poor prognosis, which suggests that it might play an important role in CRC development and progression and might have clinical potential as a useful prognostic predictor." N/A N/A N/A N/A Human N/A N/A 27042112 HOTAIR ovarian cancer Regulation An NF-κB-HOTAIR axis drives a positive feedback loop cascade during DDR and contributes to cellular senescence and chemotherapy resistance in ovarian and other cancers. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27041570 H19 nasopharyngeal carcinoma Regulation Long noncoding RNA H19 regulates EZH2 expression by interacting with miR-630 and promotes cell invasion in nasopharyngeal carcinoma. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27040767 LINC00668 gastric cancer Expression E2F1-induced upregulation of long noncoding RNA LINC00668 predicts a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically silencing of CKIs. chr18 6925474 6929869 - Human N/A NR_034100 27036039 ENST00000436681 congenital heart defect Regulation The lncRNA aberrantly expressed in the plasma of pregnant women with typical fetal CHD may play a key role in the development of CHD and may be used as novel biomarkers for prenatal diagnosis of fetal CHD. chr21 21300990 21325042 - Human AP000552.1 ENST00000436681 27035723 H19 congenital heart defect Regulation The lncRNA aberrantly expressed in the plasma of pregnant women with typical fetal CHD may play a key role in the development of CHD and may be used as novel biomarkers for prenatal diagnosis of fetal CHD. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27035723 AA584040 congenital heart defect Regulation The lncRNA aberrantly expressed in the plasma of pregnant women with typical fetal CHD may play a key role in the development of CHD and may be used as novel biomarkers for prenatal diagnosis of fetal CHD. N/A N/A N/A N/A Human N/A N/A 27035723 AA709223 congenital heart defect Regulation The lncRNA aberrantly expressed in the plasma of pregnant women with typical fetal CHD may play a key role in the development of CHD and may be used as novel biomarkers for prenatal diagnosis of fetal CHD. N/A N/A N/A N/A Human N/A N/A 27035723 BX478947 congenital heart defect Regulation The lncRNA aberrantly expressed in the plasma of pregnant women with typical fetal CHD may play a key role in the development of CHD and may be used as novel biomarkers for prenatal diagnosis of fetal CHD. N/A N/A N/A N/A Human N/A N/A 27035723 PCAT1 hepatocellular carcinoma Regulation "Upregulation of long non coding RNA PCAT-1 contributes to cell proliferation, migration and apoptosis in hepatocellular carcinoma." chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 27035680 MIR100HG cervical cancer Expression MIR100HG and AC024560.2 may be a potential biomarkers of PLNM and these lncRNAs may provide broader perspective for combating cervical cancer metastasis. chr11 122089103 122203062 - Human AGD1; linc-NeD125; lncRNA-N2 NR_137175 27035672 AC024560.2 cervical cancer Expression MIR100HG and AC024560.2 may be a potential biomarkers of PLNM and these lncRNAs may provide broader perspective for combating cervical cancer metastasis. chr3 197660565 197665757 - Human AC024560.1 ENST00000424493 27035672 NONHSAT104436 esophageal squamous cell carcinoma Regulation NONHSAT104436 might play a very important part in ESCC tumor progression. N/A N/A N/A N/A Human N/A N/A 27035335 CTD903 colorectal cancer Regulation "LncRNA-CTD903 acts as a tumor suppressor in CRC and can inhibit cell invasion and migration through repressing Wnt/β-catenin signaling, which plays important roles in EMT and CRC metastasis." N/A N/A N/A N/A Human N/A N/A 27035092 lnc13 celiac disease Locus The long noncoding RNA lnc13 associated with susceptibility to celiac disease N/A N/A N/A N/A Human N/A N/A 27034373 NEAT1 multiple sclerosis Regulation The lncRNA may be involved in MS pathogenesis. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27034068 TUG1 multiple sclerosis Regulation The lncRNA may be involved in MS pathogenesis. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 27034068 RN7SK multiple sclerosis Regulation The lncRNA may be involved in MS pathogenesis. chr6 52995620 52995951 + Human 7SK NR_001445 27034068 GAS5 breast cancer Expression This work identifies GAS5 as a novel prognostic marker and candidate drug target for HER2-positive breast cancer. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 27034004 POU6F2-AS2 oesophageal squamous cell carcinoma N/A Long noncoding RNA POU6F2-AS2 is associated with oesophageal squamous cell carcinoma. chr7 38983374 39005304 - Human N/A NR_138047 27033944 C2dat1 ischemic brain injury Regulation "A novel I/R-induced lncRNA C2dat1 that modulates the expression of CaMKIIδ to impact neuronal survival, and may be a potential target for therapeutic intervention of ischemic brain injury." N/A N/A N/A N/A Human N/A N/A 27031970 HOTAIR pancreatic cancer Expression Salivary HOTAIR and PVT1 show potential as novel non-invasive biomarkers for detecting PC. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 27028998 PVT1 pancreatic cancer Expression Salivary HOTAIR and PVT1 show potential as novel non-invasive biomarkers for detecting PC. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 27028998 ATB hepatocellular carcinoma N/A UTMD-mediated siRNA transfection against lncRNA-ATB may be a promising therapy for HCC metastasis. N/A N/A N/A N/A Human N/A N/A 27027475 H19 colorectal cancer Expression "rs2839698 in H19 was associated with elevated risk of colorectal cancer, which may be a potential biomarker for predicting colorectal cancer susceptibility." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27027436 CDKN2B-AS1 gastric cancer Regulation ANRIL knockdown blocks the effects of TET2 on gastric cancer cell proliferation and colony formation. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 27027260 MIR503HG choriocarcinoma Regulation "LincRNAs MIR503HG and LINC00629 impaired migration and invasion capacities in a choriocarcinoma in vitro model, indicating a potential role in human reproduction and tumorigenesis." chrX 134543377 134546630 - Human H19X2; MIR503HG NR_024607 27023770 LINC00629 choriocarcinoma Regulation "LincRNAs MIR503HG and LINC00629 impaired migration and invasion capacities in a choriocarcinoma in vitro model, indicating a potential role in human reproduction and tumorigenesis." chrX 134550024 134560398 + Human LINC00629AB; LINC00629C; LINC00629D; LINC00629 NR_038998 27023770 CILinc01 osteoarthritis Expression "The inflammatory response in human OA chondrocytes is associated with widespread changes in the profile of lncRNAs, including PACER, CILinc01, and CILinc02." N/A N/A N/A N/A Human N/A N/A 27023358 CILinc02 osteoarthritis Expression "The inflammatory response in human OA chondrocytes is associated with widespread changes in the profile of lncRNAs, including PACER, CILinc01, and CILinc02." N/A N/A N/A N/A Human N/A N/A 27023358 PACERR osteoarthritis Expression "The inflammatory response in human OA chondrocytes is associated with widespread changes in the profile of lncRNAs, including PACER, CILinc01, and CILinc02." chr1 186680654 186681446 + Human PACER; PTGS2-AS1 NR_125801 27023358 FGFR3-AS1 osteosarcoma Regulation Long noncoding RNA FGFR3-AS1 promotes osteosarcoma growth through regulating its natural antisense transcript FGFR3. N/A N/A N/A N/A Human N/A N/A 27022737 H19 Parkinson's disease Expression It may be used in monitoring disease progression and it may serve as potential new targets for novel therapeutic approaches. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 27021022 MALAT1 Parkinson's disease Expression It may be used in monitoring disease progression and it may serve as potential new targets for novel therapeutic approaches. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27021022 SNHG1 Parkinson's disease Expression It may be used in monitoring disease progression and it may serve as potential new targets for novel therapeutic approaches. chr11 62851988 62855888 - Human LINC00057; NCRNA00057; U22HG; UHG; lncRNA16 NR_003098 27021022 NEAT1 Parkinson's disease Expression It may be used in monitoring disease progression and it may serve as potential new targets for novel therapeutic approaches. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 27021022 MALAT1 proliferative vitreoretinopathy Regulation LncRNA MALAT1 is involved in TGFβ1 induced EMT of human RPE cells and provides new understandings for the pathogenesis of PVR. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27019196 HIF1A-AS2 bladder cancer Regulation Tetracycline-inducible shRNA targeting antisense long non-coding RNA HIF1A-AS2 represses the malignant phenotypes of bladder cancer. chr14 61747039 61749089 - Human 3'aHIF-1A; aHIF NR_045406 27018306 CCAT2 bladder cancer Regulation ShRNA targeting long non-coding RNA CCAT2 controlled by tetracycline-inducible system inhibits progression of bladder cancer cells. chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 27015551 MALAT1 esophageal squamous cell carcinoma Regulation "MALAT1 promotes the initiation and progression of ESCC, suggesting that inhibition of MALAT1 might be a potential target for treatment of ESCC." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27015363 CASC11 colorectal cancer Expression The novel lncRNA CASC11 may serve as a candidate diagnostic biomarker and a promising therapeutic target for CRC. chr8 127700608 127733967 - Human CARLo-7; LINC00990; TCONS_00014535 NR_117101 27012187 TINCR colorectal cancer Regulation Loss of TINCR expression promotes proliferation and metastasis in CRC and it could be considered as a potential cancer suppressor gene. chr19 5558167 5568034 - Human LINC00036; NCRNA00036; PLAC2; onco-lncRNA-16 NR_027064 27009809 UCA1 hepatocellular carcinoma Regulation HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2 and repressing p27Kip1/CDK2 signaling. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 27009634 SAMMSON melanoma Locus Silencing of the lineage addiction oncogene SAMMSON disrupts vital mitochondrial functions in a cancer-cell-specific manner chr3 69999744 70015301 + Human LINC01212 NR_110000 27008969 TUSC7 hepatocellular carcinoma Regulation "TUSC7 suppresses EMT through the TUSC7-miR-10a-EphA4 axis, which may be a potential target for therapeutic intervention in HCC." chr3 116709788 116717040 + Human LINC00902; LSAMP-AS1; LSAMP-AS3; LSAMPAS3; NCRNA00295 NR_015391 27002617 HOTAIR hepatocellular carcinoma Expression Long non-coding RNA HOTAIR is a marker for hepatocellular carcinoma progression and tumor recurrence. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26998078 MALAT1 lung cancer N/A MALAT-1 silencing may be an effective therapeutic approach against tumors. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26998053 MALAT1 bladder cancer N/A MALAT-1 silencing may be an effective therapeutic approach against tumors. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26998053 MALAT1 hepatocellular carcinoma N/A MALAT-1 silencing may be an effective therapeutic approach against tumors. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26998053 FTX hepatocellular carcinoma Expression It may serve as a novel prognostic biomarker and therapeutic target for HCC. chrX 74028136 74293574 - Human LINC00182; MIR374AHG; NCRNA00182 NR_028379 26992218 MEG3 hepatocellular carcinoma Regulation Armored long non-coding RNA MEG3 targeting EGFR based on recombinant MS2 bacteriophage virus-like particles against hepatocellular carcinoma. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26992211 H19 colorectal cancer Regulation Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26989025 DANCR osteosarcoma Locus ANCR might be an oncogenic lncRNA that promoted proliferation of osteosarcoma. chr4 52712454 52714138 + Human AGU2; ANCR; KIAA0114; SNHG13; lncRNA-ANCR NR_024031 26986815 CCAT2 cervical cancer Regulation LncRNA CCAT2 promoted the proliferation and survival of cervical cancer cells. chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 26983975 H19 glioma Regulation Suppressing H19 Modulates Tumorigenicity and Stemness in U251 and U87MG Glioma Cells. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26983719 HULC atherosclerosis Regulation HULC-miR-9 pathway may be a potential target for treating atherosclerosis. chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 26981838 EPB41L4A-AS2 breast cancer Regulation The long non-coding RNA EPB41L4A-AS2 inhibits tumor proliferation and is associated with favorable prognoses in breast cancer and other solid tumors. chr5 112419583 112420978 + Human N/A NR_027706 26980733 EPB41L4A-AS2 kidney cancer Regulation The long non-coding RNA EPB41L4A-AS2 inhibits tumor proliferation and is associated with favorable prognoses in breast cancer and other solid tumors. chr5 112419583 112420978 + Human N/A NR_027706 26980733 EPB41L4A-AS2 lung cancer Regulation The long non-coding RNA EPB41L4A-AS2 inhibits tumor proliferation and is associated with favorable prognoses in breast cancer and other solid tumors. chr5 112419583 112420978 + Human N/A NR_027706 26980733 HOTAIR Parkinson's disease Regulation HOTAIR promoted PD induced by MPTP through regulating LRRK2 expression could add our understanding of the molecular mechanisms in PD. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26979073 TUG1 prostate cancer N/A It plays an important role in prostate cancer. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 26975529 CTB-89H12.4 prostate cancer N/A It plays an important role in prostate cancer. chr5 149494314 149504670 - Human AC021078.1 ENST00000499521 26975529 ucoo2kmd.1 colorectal cancer Expression The overexpression oflncRNA-uc002kmd.1 enhanced cell proliferation in CRC. N/A N/A N/A N/A Human N/A N/A 26974151 SARCC renal cell carcinoma Regulation Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2α/C-MYC axis under hypoxia. N/A N/A N/A N/A Human N/A N/A 26973243 Pvt1 diabetes mellitus Regulation Autophagy ameliorates cognitive impairment through activation of PVT1 and apoptosis in diabetes mice. chr15 62037986 62260215 + Mouse Ayu21-84Imeg; Gt(pU21)84Imeg; Mis-1; Mlvi-1; Pvt-1 NR_003368 26971628 SRA breast cancer Regulation SRA genetic variants may contribute to BC risk and have apparent interaction with reproductive factors in BC progression. N/A N/A N/A N/A Human N/A N/A 26967566 EVI1 hepatocellular carcinoma Regulation EVI1 is frequently up-regulated and regulates a cluster of lncRNAs in HBV related hepatocellular carcinoma (HCC). N/A N/A N/A N/A Human N/A N/A 26967394 HOTAIR osteosarcoma Mutation Genetic variants of lncRNA HOTAIR contribute to the risk of osteosarcoma. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26967389 PCA3 prostate cancer Regulation PCA3 was the first lncRNA identified in prostate cancer and has been shown to be expressed in a majority of prostate cancer cases. chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 26965999 CBR3-AS1 prostate cancer Regulation "Other lncRNAs are known to interact directly with the androgen receptor pathway including PlncRNA-1, HOTAIR, PRNCR1 and PCGEM1. " chr21 36131767 36156308 - Human PlncRNA-1; PlncRNA1 NR_038894 26965999 HOTAIR prostate cancer Regulation "Other lncRNAs are known to interact directly with the androgen receptor pathway including PlncRNA-1, HOTAIR, PRNCR1 and PCGEM1. " chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26965999 PRNCR1 prostate cancer Regulation "Other lncRNAs are known to interact directly with the androgen receptor pathway including PlncRNA-1, HOTAIR, PRNCR1 and PCGEM1. " chr8 127079874 127092595 + Human CARLo-3; PCAT8 NR_109833 26965999 PCGEM1 prostate cancer Regulation "Other lncRNAs are known to interact directly with the androgen receptor pathway including PlncRNA-1, HOTAIR, PRNCR1 and PCGEM1. " chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 26965999 MALAT1 retinal neurodegeneration Regulation MALAT1 might regulate the development of retinal neurodegeneration through CREB signaling. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26964565 HOTAIR colon cancer Regulation MiR-125a-5p decreases after long non coding RNA HOTAIR knockdown to promote cancer cell apoptosis by releasing caspase 2. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26962687 PCA3 prostate cancer Regulation PCA3 long noncoding RNA modulates the expression of key cancer-related genes in LNCaP prostate cancer cells. chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 26960690 TCONS_00003876 breast cancer N/A It might play a role in HER2-positive breast cancer. N/A N/A N/A N/A Human N/A N/A 26957268 lnc-HOXC4-3:1 breast cancer N/A It might play a role in HER2-positive breast cancer. N/A N/A N/A N/A Human N/A N/A 26957268 lnc-TEAD4-1:1 breast cancer N/A It might play a role in HER2-positive breast cancer. N/A N/A N/A N/A Human N/A N/A 26957268 MIAT dilated cardiomyopathy Expression MIAT is a specific biomarker of CCC. chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 26951817 RGMB-AS1 lung adenocarcinoma Regulation LncRNA RGMB-AS1 may play an important role in lung adenocarcinoma and may serve as a potential therapeutic target. chr5 98769618 98773084 - Human N/A NR_033932 26950071 UCA1 acute myocardial infarction Expression The circulating UCA1 could be used as a promising novel biomarker for the diagnosis and/or prognosis of AMI. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26949706 MALAT1 non-small cell lung cancer N/A It can serve as a convenient tool for early NSCLC diagnosis. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26946307 CDKN2B-AS1 hypertension Mutation Polymorphisms in the long non-codingRNA CDKN2B-AS1 may contribute to higher systolic blood pressure levels in hypertensive patients. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 26944720 HOTAIR glioblastoma N/A It plays an important role in glioblastoma chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26943771 NORAD breast cancer Regulation "LINC00657 knockout significantly suppresses tumor cell growth and proliferation, suggesting that it plays an oncogenic role." chr20 36045618 36050960 - Human LINC00657 NR_027451 26942882 GAS8-AS1 papillary thyroid carcinoma Expression LncRNA GAS8-AS1 and LPAR4 as potential diagnostics and therapeutic targets. chr16 90028908 90029901 - Human C16orf3 NR_122031 26941397 MALAT1 glioma Regulation The tumor-suppressive role of MALAT1 in glioma by attenuating ERK/MAPK-mediated growth and MMP2 mediated invasiveness. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26938295 BC012900 ulcerative colitis Regulation The lncRNA may be an integral modulator of intestinal inflammation associated with IBD and represent a novel target for future therapeutics and diagnostic marker development. N/A N/A N/A N/A Human N/A N/A 26937624 LET esophageal squamous cell carcinoma Regulation Long non-coding RNA-Low Expression in Tumor inhibits the invasion and metastasis of esophageal squamous cell carcinoma by regulating p53 expression. N/A N/A N/A N/A Human N/A N/A 26935396 UCA1 renal cell carcinoma Expression "UCA1 may be consider as a promising biomarker for diagnosis, and a therapeutic target in RCC." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26935146 HOTAIR gastric cancer Expression HOTAIR was significantly correlated with tumor size and lymphatic metastasis (p<0.05) chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26935047 UCA1 gastric cancer Expression "UCA1 was significantly correlated with tumor size, TNM stage and lymphatic metastasis (p<0.05)" chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26935047 MALAT1 hepatic steatosis Regulation MALAT1 promotes hepatic steatosis and insulin resistance by increasing nuclear SREBP-1c protein stability. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26935028 DQ786243 colorectal cancer Regulation LncRNA DQ786243 contributes to proliferation and metastasis of colorectal cancer both in vitro and in vivo N/A N/A N/A N/A Human N/A N/A 26934980 TRIM52-AS1 renal cell carcinoma Regulation Downregulation of long non-coding RNA TRIM52-AS1 functions as a tumor suppressor in renal cell carcinoma. chr5 181261212 181272307 + Human N/A NR_102762 26934858 MEG3 colorectal cancer Mutation Genetic variants in MEG3 may contribute to the development and risk of colorectal cancer. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26934323 H19 gastric cancer Regulation Long Noncoding RNA H19-Derived miR 675 Enhances Proliferation and Invasion via RUNX1 in Gastric Cancer Cells. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26931432 LINC00636 breast cancer Expression It provides useful information for exploring candidate therapeutic targets and new molecular biomarkers for HER-2-enriched subtype breast cancer. chr3 107883205 107928907 + Human N/A NR_015394 26929647 LINC01405 breast cancer Expression It provides useful information for exploring candidate therapeutic targets and new molecular biomarkers for HER-2-enriched subtype breast cancer. chr12 110936602 110937448 + Human N/A NR_036513 26929647 ADARB2-AS1 breast cancer Expression It provides useful information for exploring candidate therapeutic targets and new molecular biomarkers for HER-2-enriched subtype breast cancer. chr10 1526630 1556984 + Human C10orf109; NCRNA00168; bA466B20.1 NR_033387 26929647 ST8SIA6-AS1 breast cancer Expression It provides useful information for exploring candidate therapeutic targets and new molecular biomarkers for HER-2-enriched subtype breast cancer. chr10 17386936 17408286 + Human N/A NR_034129 26929647 LINC00511 breast cancer Expression It provides useful information for exploring candidate therapeutic targets and new molecular biomarkers for HER-2-enriched subtype breast cancer. chr17 72598041 72640472 - Human LCAL5; onco-lncRNA-12 NR_033876 26929647 DPP10-AS1 breast cancer Expression It provides useful information for exploring candidate therapeutic targets and new molecular biomarkers for HER-2-enriched subtype breast cancer. chr2 115144048 115161343 - Human N/A NR_036580 26929647 PVT1 lung squamous cell carcinoma Regulation "Its targets and regulators, may play crucial roles in the progress of LUSC." chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 26928440 TERC lung squamous cell carcinoma Regulation "Its targets and regulators, may play crucial roles in the progress of LUSC." chr3 169764610 169765060 - Human DKCA1; PFBMFT2; SCARNA19; TR; TRC3; hTR NR_001566 26928440 PANDAR breast cancer Regulation LncRNA PANDAR regulates the G1/S transition of breast cancer cells by suppressing p16(INK4A) expression. chr6 36673621 36675126 - Human PANDA NR_109836 26927017 MALAT1 breast cancer Regulation MALAT1 regulated migration and invasion of breast cancer cells via affecting cdc42 through binding miR-1 competitively. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26926567 PVT1 gastric cancer Expression PVT1 might serve as a promising biomarker early detection and prognosis prediction of gastric cancer. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 26925791 CYP4B1-PS1 diabetic nephropathy Regulation A novel long non-coding RNA CYP4B1 PS1-001 regulates proliferation and fibrosis in diabetic nephropathy. N/A N/A N/A N/A Human N/A N/A 26923441 CCAT1 acute myeloid leukemia Expression The manipulation of CCAT1 expression could serve as a potential strategy in AML therapy. chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 26923190 HIF1A-AS2 breast cancer Regulation HIF1A-AS2 and AK124454 promoted cell proliferation and invasion in TNBC cells and contributed there to paclitaxel resistance. chr14 61747039 61749089 - Human 3'aHIF-1A; aHIF NR_045406 26921339 AK124454 breast cancer Regulation HIF1A-AS2 and AK124454 promoted cell proliferation and invasion in TNBC cells and contributed there to paclitaxel resistance. N/A N/A N/A N/A Human N/A N/A 26921339 BC088254 myocardial hypertrophy Regulation lncRNA BC088254 may have a certain role in myocardial hypertrophy induced by TAC N/A N/A N/A N/A Human N/A N/A 26919297 LCAL6 lung adenocarcinoma Expression The lung cancer associated lncRNA 6 (LCAL6) was significantly unregulated and predicted survival in LUAD. N/A N/A N/A N/A Human N/A N/A 26918601 MALAT1 breast cancer Regulation MiR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26918449 MALAT1 breast cancer Expression Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of has miR-448. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26917489 TUG1 gastric cancer Regulation "TUG1, as a regulator of proliferation, may serve as a candidate prognostic biomarker and target for new therapies in human GC." chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 26913601 NEAT1 gastric adenocarcinoma Expression Expression of NEAT1 lncRNA was enhanced in GACs; and NEAT1 may influence GAC progression by promoting tumor growth. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 26911892 RP11-434D9.1 breast cancer N/A It is correlated with TNBC occurrence chr5 67379378 67805238 + Human AC112206.2 ENST00000509947 26910840 LINC00052 breast cancer N/A It is correlated with TNBC occurrence chr15 87576929 87579686 + Human NCRNA00052; TMEM83 NR_026869 26910840 BC016831 breast cancer N/A It is correlated with TNBC occurrence N/A N/A N/A N/A Human N/A N/A 26910840 IGKV breast cancer N/A It is correlated with TNBC occurrence N/A N/A N/A N/A Human N/A N/A 26910840 MALAT1 renal cell carcinoma Expression MALAT-1 can be used to predict unfavorable prognoses for RCC. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26909935 PVT1 non-small cell lung cancer Regulation PVT1/EZH2/LATS2 interactions might serve as new target for lung adenocarcinoma diagnosis and therapy. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 26908628 NONHSAT040387 atrial fibrillation N/A It plays an important role in AF N/A N/A N/A N/A Human N/A N/A 26908457 NONHSAT098586 atrial fibrillation N/A It plays an important role in AF N/A N/A N/A N/A Human N/A N/A 26908457 NR_026689 lung cancer Expression LncRNA NR_026689 may be a potential early biomarker for lung cancer and is associated with lung carcinogenesis induced by NNK N/A N/A N/A N/A Human N/A N/A 26908441 CBR3-AS1 hepatocellular carcinoma Locus PlncRNA-1 may serve as an oncogene in HCC progression and represent a valuable prognostic marker and potential therapeutic target for HCC. chr21 36131767 36156308 - Human PlncRNA-1; PlncRNA1 NR_038894 26906068 lnc-LAMC2-1:1 colorectal cancer Locus rs2147578 in lnc-LAMC2-1:1 might be a genetic modifier for the development of CRC. N/A N/A N/A N/A Human N/A N/A 26905585 LINC-ROR pancreatic cancer Regulation "linc-ROR acts as an important regulator of ZEB1, can promote invasion and metastasis in PC, and may represent a novel therapeutic target." chr18 57054571 57072119 - Human ROR; lincRNA-RoR NR_048536 26898939 PANDAR gastric cancer Expression PANDAR may be a potential novel biomarker that predicts prognosis in gastric cancer. chr6 36673621 36675126 - Human PANDA NR_109836 26898439 MEG3 metabolic syndrome Expression "Pioglitazone up-regulated MEG3 expression to protect EPCs via decreasing miR-140-5p expression and increasing HDAC7 expression in MetS, which may be a novel therapeutic target for preventing and treating MetS." chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26898430 MIF-AS1 nephrolithiasis Mutation The MIF-AS rs755622 polymorphism may have a crucial role in the development of nephrolithiasis. chr22 23893710 23898930 - Human MIF-AS NR_038911 26895959 AB209630 hypopharyngeal squamous cell carcinoma Expression "AB209630, a long non-coding RNA decreased expression in hypopharyngeal squamous cell carcinoma, influences proliferation, invasion, metastasis, and survival." N/A N/A N/A N/A Human N/A N/A 26895099 HULC glioma Regulation HULC long noncoding RNA silencing suppresses angiogenesis by regulating ESM-1 via the PI3K/Akt/mTOR signaling pathway in human gliomas. chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 26894862 BCYRN1 ovarian cancer Regulation BC200 appears to serve a role in the mediation of carboplatin-induced ovarian cancer cell death. chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 26893717 AFAP1-AS1 hepatocellular carcinoma Regulation Long noncoding RNA AFAP1-AS1 indicates a poor prognosis of hepatocellular carcinoma and promotes cell proliferation and invasion via upregulation of the RhoA/Rac2 signaling. chr4 7754090 7778928 + Human AFAP1-AS; AFAP1AS NR_026892 26892468 PVT1 breast cancer Regulation "It leads to increased premalignant features, and ultimately to tumor formation." chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 26889781 PVT1 breast cancer Regulation "It leads to increased premalignant features, and ultimately to tumor formation." chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 26889781 MALAT1 colorectal cancer Regulation Long non-coding RNA MALAT1 increases AKAP-9 expression by promoting SRPK1-catalyzed SRSF1 phosphorylation in colorectal cancer cells. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26887056 H19 breast cancer Mutation Genetic Polymorphisms in Long Noncoding RNA H19 Are Associated With Susceptibility to Breast Cancer in Chinese Population. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26886624 MEG3 tongue squamous cell carcinoma Expression MEG3 emerges as an independent prognostic factor for poor clinical outcomes in TSCC patients chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26885901 AK021954 atherosclerosis Regulation LncRNA AK021954 gene and FGF18 involved in baicalein inhibiting the proliferation of VSMCs. It may provide a promising method in treatment of atherosclerosis. N/A N/A N/A N/A Human N/A N/A 26885187 UCA1 colon cancer Expression Plasma UCA1 may serve as a potential biomarker for early diagnosis and disease monitoring of colon cancer patients. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26885155 PVT1 ovarian cancer Expression Overexpression of LncRNA PVT1 in ovarian cancer promotes cisplatin resistance by regulating apoptotic pathways. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 26884974 AK123072 gastric cancer Regulation Hypoxia/lncRNA-AK123072/EGFR pathway in gastric cancer pathogenesis and this might help in the development of new therapeutics in clinics. N/A N/A N/A N/A Human N/A N/A 26884908 MALAT1 non-small cell lung cancer Locus MALAT1 is an oncogenic long non-coding RNA associated with tumor invasion in non-small cell lung cancer regulated by DNA methylation. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26884862 SPRY4-IT1 esophageal squamous cell carcinoma Regulation "Long noncoding RNA SPRY4-IT1 promotes esophageal squamous cell carcinoma cell proliferation, invasion, and epithelial mesenchymal transition." chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 26883252 LINC01852 non-small cell lung cancer Expression ENST00000434223 may be a potential biomarker and a therapeutic target of NSCLC. chr15 38069032 38073262 - Human N/A NR_147201 26883250 LET renal cell carcinoma Expression It can be a promising new class of biomarkers for tumour diagnosis N/A N/A N/A N/A Human N/A N/A 26878386 PVT1 renal cell carcinoma Expression It can be a promising new class of biomarkers for tumour diagnosis chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 26878386 PANDAR renal cell carcinoma Expression It can be a promising new class of biomarkers for tumour diagnosis chr6 36673621 36675126 - Human PANDA NR_109836 26878386 PTENP1 renal cell carcinoma Expression It can be a promising new class of biomarkers for tumour diagnosis chr9 33673504 33677499 - Human PTENP1 ENST00000532280 26878386 LINC00963 renal cell carcinoma Expression It can be a promising new class of biomarkers for tumour diagnosis chr9 129488660 129513686 + Human N/A NR_038955 26878386 KRT7-AS gastric cancer Regulation "KRT7-AS promotes GC, at least in part, by increasing KRT7 expression." chr12 52245043 52247448 - Human N/A NR_146274 26876208 H19 laryngeal squamous cell carcinoma Regulation The lncRNA H19 promoted LSCC progression via miR-148a-3p and DNMT1. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26872375 SLC26A4-AS1 cardiac hypertrophy N/A The lncRNA played an important role in the CH chr7 107656516 107661798 - Human N/A NR_028137 26872060 RP11-344E13.3 cardiac hypertrophy N/A The lncRNA played an important role in the CH chr17 20868433 21002276 + Human CCDC144NL-AS1 ENST00000584433 26872060 MAGI1-IT1 cardiac hypertrophy N/A The lncRNA played an important role in the CH chr3 65872813 65954558 - Human N/A NR_145422 26872060 LncPPARδ coronary artery disease Expression "LncPPARδ, especially combined with risk factors, can be a good biomarker for CAD." N/A N/A N/A N/A Human N/A N/A 26871769 MALAT1 gastric cancer Regulation MALAT1 long ncRNA promotes gastric cancer metastasis by suppressing PCDH10. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26871474 KCNQ1OT1 colorectal cancer Regulation β-catenin signaling may contribute to development of colorectal cancer by functioning as a novel lncRNA regulatory factor via direct targeting of KCNQ1OT1. chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 26868975 HOTAIR endometrial cancer Expression HOTAIR expression could serve as an independent prognostic factor in EC. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26868332 UCA1 ovarian cancer Expression "UCA1 is a new prognostic biomarker for EOC, establishing a novel connection among UCA1, miR-485-5p, and MMP14 in EOC metastasis." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26867765 NONRATT021972 diabetes mellitus Regulation Inhibition of it may serve as a novel therapeutic strategy for diabetes complicated with nervous inflammatory diseases. N/A N/A N/A N/A Rat N/A N/A 26865268 OR3A4 gastric cancer Regulation Long noncoding RNA OR3A4 promotes metastasis and tumorigenicity in gastric cancer. N/A N/A N/A N/A Human N/A N/A 26863570 GAS5 breast cancer Regulation "The GAS5 lncRNA HREM sequence alone is sufficient to induce apoptosis in breast cancer cells, including triple-negative breast cancer cells." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26862727 SOX2-OT esophageal squamous cell carcinoma Regulation Down-Regulatory Effects of miR-211 on Long Non-Coding RNA SOX2OT and SOX2 Genes in Esophageal Squamous Cell Carcinoma. chr3 181056680 181742228 + Human NCRNA00043; SOX2OT NR_075089 26862518 CASC15 basal cell carcinoma N/A The lncRNA may play a role in the molecular pathogenesis of BCC chr6 21666444 22194400 + Human LINC00340; lnc-SOX4-1 NR_015410 26861560 CDKN2B-AS1 basal cell carcinoma N/A The lncRNA may play a role in the molecular pathogenesis of BCC chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 26861560 SCHLAP1 bladder cancer Locus SChLAP1 plays oncogenic roles and can be used as a therapeutic target for treating human bladder cancer. chr2 180692104 180916939 + Human SCHLAP1 ENST00000629145 26861061 RP11-181G12.2 lung adenocarcinoma N/A It may play a key role in tumor development. chr1 2181794 2184389 - Human PRKCZ-AS1 ENST00000333854 26857641 RP11-89K21 lung adenocarcinoma N/A It may play a key role in tumor development. N/A N/A N/A N/A Human N/A N/A 26857641 OTTHUMT00000387022 coronary artery disease Expression It is a novel and specific biomarker of CAD. N/A N/A N/A N/A Human N/A N/A 26857419 TUG1 colorectal cancer Regulation The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial mesenchymal transition. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 26856330 KRT18P55 gastric cancer Expression "Upregulated KRT18P55 was a novel biomarker for the progression of GC, especially for the intestinal type." chr17 28275986 28317783 - Human KRT18P55 ENST00000578578 26855593 MALAT1 cervical cancer Expression "Human MALAT-1 long non-coding RNA is overexpressed in cervical cancer metastasis and promotes cell proliferation, invasion and migration." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26854446 UCA1 ovarian cancer Expression UCA1 may serve as an indicator of response to chemotherapy and prognosis of ovarian cancer and UCA1 may play an important role in the progression of ovarian cancer. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26851957 MEG3 pancreatic cancer Regulation fenofibrate inhibited pancreatic cancer cells proliferation via activation of p53 mediated by upregulation of MEG3. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26850851 MALAT1 pancreatic cancer Regulation "EZH2 promotes cell migration and invasion but not alters cell proliferation by suppressing E-cadherin, partly through association with MALAT-1 in pancreatic cancer." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26848980 FEZF1-AS1 colorectal cancer Regulation "The dysregulation of FEZF1-AS1 participates in colorectal tumorigenesis and progression, which might be achieved, at least in part, through FEZF1 induction." chr7 122303658 122310077 + Human N/A NR_036484 26848625 MALAT1 neuroblastoma Expression "Up-regulation of MALAT1 expression in human neuroblastoma cells under hypoxic conditions increases FGF2 expression and promotes vasculature formation, and therefore plays an important role in tumor-driven angiogenesis." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26848616 lncRNA-ATB renal cell carcinoma Expression High expression of long non-coding RNA lncRNA-ATB is correlated with metastases and promotes cell migration and invasion in renal cell carcinoma. N/A N/A N/A N/A Human N/A N/A 26848077 GAS5 melanoma Regulation Lentiviral-mediated overexpression of long non-coding RNA GAS5 reduces invasion by mediating MMP2 expression and activity in human melanoma cells. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26846479 SOX2-OT lung cancer Locus Our findings support a potential oncogenic role for SOX2OT in non-small cell lung cancer tumor genesis and SOX2OT seems a promising therapeutic candidate for NSCLC. chr3 181056680 181742228 + Human NCRNA00043; SOX2OT NR_075089 26846097 MEG3 diabetes mellitus Expression MEG3 up-regulation may serve as a therapeutic strategy for treating diabetes-related microvascular complications chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26845358 LINC01133 non-small cell lung cancer Expression How LINC01133 over-expression confers an oncogenic function in NSCLC that may offer a novel therapy target in this disease. chr1 159961224 159979086 + Human N/A NR_038849 26840083 TINCR esophageal squamous cell carcinoma Regulation "TINCR promotes proliferation, migration and invasion of ESCC cells, acting as a potential oncogene of ESCC." chr19 5558167 5568034 - Human LINC00036; NCRNA00036; PLAC2; onco-lncRNA-16 NR_027064 26833746 HOXA11-AS glioma Expression HOXA11-AS could serve as a biomarker for identifying glioma molecular subtypes and as therapeutic target for glioma patients. chr7 27185408 27189293 + Human HOXA-AS51; HOXA11AS; HOXA11S; NCRNA00076; HOXA11-AS NR_002795 26828136 HOTAIR ovarian cancer Regulation "HOTAIR can promote proliferation, migration, and invasion in ovarian SKOV3 cells as a competing endogenous RNA." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26826873 FALEC thyroid cancer Regulation FAL1 may have a role in cell-cycle progression and may be associated with aggressive tumor behavior in PTC. chr1 150515757 150518032 + Human FAL1; LINC00568; ncRNA-a1 NR_051960 26825907 CCAT1 gastric cancer Regulation "The CCAT1/miR-490/hnRNPA1 axis promotes GC migration, and it may have a possible diagnostic and therapeutic potential in GC." chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 26825578 ENST00000537266 papillary thyroid carcinoma Regulation "LncRNAs(ENST00000426615 and ENST00000537266) might be important regulators of PTC cell proliferation and motility, which might provide new insight into the understanding of PTC pathogenesis." N/A N/A N/A N/A Human N/A N/A 26824456 HAGLROS papillary thyroid carcinoma Regulation "LncRNAs(ENST00000426615 and ENST00000537266) might be important regulators of PTC cell proliferation and motility, which might provide new insight into the understanding of PTC pathogenesis." chr2 176178166 176179009 + Human N/A NR_110457 26824456 uc.77 idiopathic pulmonary fibrosis Expression Overexpression of uc.77 or 2700086A05Rik in human lung epithelial cells induced EMT as demonstrated by changes in gene and protein expression of various EMT markers and cell morphology. N/A N/A N/A N/A Human N/A N/A 26824344 2700086A05Rik idiopathic pulmonary fibrosis Expression Overexpression of uc.77 or 2700086A05Rik in human lung epithelial cells induced EMT as demonstrated by changes in gene and protein expression of various EMT markers and cell morphology. chr6 52175217 52215076 + Human 2700086A05Rik ENSMUST00000131502 26824344 MEG3 osteosarcoma Expression Downregulation of lncRNA MEG3 was associated with poor overall survival of osteosarcoma and lncRNA MEG3 could be a useful biomarker for progression and prognosis of osteosarcoma. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26823857 HOTAIR asthenozoospermia Expression Low long non-coding RNA HOTAIR expression is associated with down regulation of Nrf2 in the spermatozoa of patients with asthenozoospermia or oligoasthenozoospermia. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26823733 CCAT1 colorectal cancer Expression Combination of HOTAIR and CCAT1 had a higher positive diagnostic rate of CRC than HOTAIR or CCAT1 alone. chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 26823726 HOTAIR colorectal cancer Expression Combination of HOTAIR and CCAT1 had a higher positive diagnostic rate of CRC than HOTAIR or CCAT1 alone. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26823726 PRNCR1 prostate cancer N/A It plays an important role in prostate cancer. chr8 127079874 127092595 + Human CARLo-3; PCAT8 NR_109833 26823525 PCAT1 prostate cancer N/A It plays an important role in prostate cancer. chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 26823525 PCAT2 prostate cancer N/A It plays an important role in prostate cancer. chr8 127072694 127082221 - Human CARLo-4; PCA2; TCONS_00015167 NR_119373 26823525 NEAT1 laryngeal squamous cell carcinoma Regulation NEAT1 plays an oncogenic role in the tumorigenesis of LSCC and may serve as a potential target for therapeutic intervention. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 26822763 FGF14-AS2 breast cancer Regulation A novel long non-coding RNA FGF14-AS2 is correlated with progression and prognosis in breast cancer. chr13 102394578 102395705 + Human N/A NR_036487 26820525 AK027294 colorectal cancer Regulation "AK027294 is highly expressed in colorectal cancer and closely correlates with colorectal cells proliferation, migration, and apoptosis." N/A N/A N/A N/A Human N/A N/A 26820130 MEG3 gallbladder cancer Regulation MEG3 can inhibit the proliferation of GBC cells and promote apoptosis chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26812694 CDKN2B-AS1 gallbladder cancer Regulation ANRIL can improve the proliferation of gallbladder cells and inhibit apoptosis. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 26812694 DILC liver cancer Expression "Lnc-DILC could be not only a potential prognostic biomarker, but also a possible therapeutic target against LCSCs." N/A N/A N/A N/A Human N/A N/A 26812074 CBR3-AS1 prostate cancer N/A PlncRNA-1 might warrant further investigation to determine its potential role as a promising therapeutic target in PCa. chr21 36131767 36156308 - Human PlncRNA-1; PlncRNA1 NR_038894 26808578 HOTTIP hepatocellular carcinoma Regulation FMiRNA-192 and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 26807954 RP11-395G23.3 endometrial cancer Regulation It plays an important role in the post transcriptional regulation in EC. chr8 106270144 106272899 + Human AC027031.2 ENST00000577661 26807189 LA16c-313D11.11 endometrial cancer Regulation It plays an important role in the post transcriptional regulation in EC. N/A N/A N/A N/A Human N/A N/A 26807189 LINC01158 gastric cancer Regulation Linc-POU3F3 could promote the distribution of Tregs in peripheral blood T cell which caused an enhanced cell proliferation of gastric cancer cells by recruiting TGF beta as well as activating TGF-beta signal pathway. chr2 104805425 104853183 - Human PANTR1; linc-Brn1a; linc-POU3F3 NR_037883 26807174 Hotair sepsis Regulation LncRNA-HOTAIR promotes TNF-α production in cardiomyocytes of LPS induced sepsis mice by activating NF-κB pathway. chr15 102944062 102947946 - Mouse Gm16258 NR_047528 26806307 GFRα Hirschsprung's disease Expression It is a potential diagnostic biomarker of HSCR. N/A N/A N/A N/A Human N/A N/A 26806097 H19 gallbladder cancer Regulation Long noncoding RNA H19 contributes to gallbladder cancer cell proliferation by modulated miR-194-5p targeting AKT2. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26803515 AFAP1-AS1 hepatocellular carcinoma Regulation AFAP1-AS1 is important in HCC development and serves as a therapeutic target of HCC. chr4 7754090 7778928 + Human AFAP1-AS; AFAP1AS NR_026892 26803513 HOTAIR bladder cancer Expression UE-derived lncRNA HOTAIR may potentially serve as biomarkers and therapeutic targets. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26800519 TP73-AS1 esophageal squamous cell carcinoma Regulation Knockdown of long non-coding RNA TP73-AS1 inhibits cell proliferation and induces apoptosis in esophageal squamous cell carcinoma. chr1 3735984 3747373 - Human KIAA0495; PDAM NR_033709 26799587 CYTOR gastric cancer Regulation LINC00152 may play contribute to the progression of GC and may be an effective therapeutic target. chr2 87455455 87521518 + Human C2orf59; LINC00152; NCRNA00152 NR_024204 26799422 SUMO1P3 bladder cancer Regulation SUMO1P3 plays oncogenic roles in bladder cancer and can be used as a potential prognostic and therapeutic target. chr1 160317403 160317706 + Human SUMO1P3 ENST00000439961 26799188 MALAT1 cervical cancer Regulation Down-regulation of MALAT1 inhibits cervical cancer cell invasion and metastasis by inhibition of epithelial-mesenchymal transition. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26798987 LOC400891 prostate cancer Regulation Overexpression of long non-coding RNA LOC400891 promotes tumor progression and poor prognosis in prostate cancer. N/A N/A N/A N/A Human N/A N/A 26797783 lnc-MX1-1 prostate cancer Expression Lnc-MX1-1 may serve as a potential biomarker and therapeutic target for prostate cancer. N/A N/A N/A N/A Human N/A N/A 26797523 LUNAR1 diffuse large B-cell lymphoma Regulation Long noncoding RNA LUNAR1 associates with cell proliferation and predicts a poor prognosis in diffuse large B-cell lymphoma. chr15 99014704 99031050 + Human N/A NR_126487 26796267 LINC00635 lung cancer Regulation "The long non-coding RNA, LINC00635-001, sensitizes EGFR-TKI-resistant human lung cancer cells in vitro by inhibiting Akt activation." chr3 107841662 107878068 - Human N/A NR_015414 26792719 CASC2 lung cancer Expression Low expression of long noncoding RNA CASC2 indicates a poor prognosis and regulates cell proliferation in non-small cell lung cancer. chr10 118046821 118210153 + Human C10orf5 NR_026939 26790438 BACE1-AS ovarian cancer Expression Elevation of lncRNA BACE1-AS expression is a potential mechanism for suppressing human OCSC proliferation and invasion. chr11 117291346 117292170 + Human BACE1-AS1; BACE1AS; NCRNA00177 NR_037803 26783004 TUSC7 osteosarcoma Regulation TUSC7 could be a potential tumor suppressor in osteosarcoma. chr3 116709788 116717040 + Human LINC00902; LSAMP-AS1; LSAMP-AS3; LSAMPAS3; NCRNA00295 NR_015391 26781978 HOTAIR bladder transitional cell carcinoma Expression Long noncoding RNA HOTAIR is a prognostic biomarker and inhibits chemosensitivity to doxorubicin in bladder transitional cell carcinoma. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26781446 H19 gastric cancer Expression H19 serves as a diagnostic biomarker and up-regulation of H19 expression contributes to poor prognosis in patients with gastric cancer. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26774144 PCAT1 lung cancer Regulation Long non-coding RNA PCAT-1 overexpression promotes proliferation and metastasis in non-small cell lung cancer cells. chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 26770456 UPAT colon cancer Expression UPAT and UHRF1 may be promising molecular targets for the therapy of colon cancer. N/A N/A N/A N/A Human N/A N/A 26768845 UHRF1 colon cancer Expression UPAT and UHRF1 may be promising molecular targets for the therapy of colon cancer. N/A N/A N/A N/A Human N/A N/A 26768845 NONHSAT123350 renal clear cell carcinoma Regulation NONHSAT123350 could be involved in the pathogenesis of RCCC and its expression level was closely related to disease-free survival (DFS) and overall survival (OS) in patients without distant metastasis. N/A N/A N/A N/A Human N/A N/A 26765468 MHRT acute myocardial infarction Expression The plasma concentration of MHRT may serve as a biomarker for myocardial infarction diagnosis in humans AMI. chr14 23415450 23417595 + Human Myheart NR_126491 26759697 BANCR hepatocellular carcinoma Regulation BANCR may contribute to HCC initiation and progression and would be used as not only a novel prognostic marker but also a potential therapeutic target for this disease. chr9 69296681 69307056 - Human LINC00586 NR_047671 26758762 HNF1A-AS1 nasopharyngeal carcinoma Regulation Long non-coding RNA HNF1A-AS is upregulated and promotes cell proliferation and metastasis in nasopharyngeal carcinoma. chr12 120969838 120972292 - Human C12orf27; NCRNA00262 NR_024345 26756620 AFAP1-AS1 esophageal squamous cell carcinoma Expression High expression of long non-coding RNA AFAP1-AS1 predicts chemoradioresistance and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. chr4 7754090 7778928 + Human AFAP1-AS; AFAP1AS NR_026892 26756568 NUTF2P3 pancreatic cancer Expression lncRNA-NUTF2P3-001 and miR-3923 can be applied as novel predictors and therapeutic targets for pancreatic cancer. chr9 77580245 77580628 + Human NUTF2P3 ENST00000448540 26755660 CCAT1 colorectal cancer Regulation CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 26752646 TUG1 glioma Regulation LncRNA TUG1 acts as a tumor suppressor in human glioma by promoting cell apoptosis. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 26748401 NONRATT021972 type 2 diabetes mellitus Regulation NONRATT021972 siRNA treatment may suppress the upregulated expression and activation of the P2X3 receptor and reduce the hyperalgesia potentiated by the pro-inflammatory cytokine TNF-α in T2DM rats. N/A N/A N/A N/A Rat N/A N/A 26742527 PCNA-AS1 gastric cancer Regulation IncRNA-PCNA-AS1 may participate in the gastric cancer carcinogenesis and development and may serve as a new biomarker for patients with gastric cancer. chr20 5119586 5119969 + Human PCNA-AS; PCNAAS NR_028370 26731993 HOTTIP lung cancer Expression It may be potentialnclinical biomarkers to predict lung cancernrisk and platinum-based chemotherapynresponse. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 26729200 CCAT2 lung cancer Expression It may be potentialnclinical biomarkers to predict lung cancernrisk and platinum-based chemotherapynresponse. chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 26729200 H19 lung cancer Expression It may be potentialnclinical biomarkers to predict lung cancernrisk and platinum-based chemotherapynresponse. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26729200 HOTAIR lung cancer Expression It may be potentialnclinical biomarkers to predict lung cancernrisk and platinum-based chemotherapynresponse. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26729200 MALAT1 lung cancer Expression It may be potentialnclinical biomarkers to predict lung cancernrisk and platinum-based chemotherapynresponse. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26729200 CDKN2B-AS1 lung cancer Expression It may be potentialnclinical biomarkers to predict lung cancernrisk and platinum-based chemotherapynresponse. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 26729200 SCHLAP1 prostate cancer Expression Overexpression of the Long Non-coding RNA SChLAP1 Independently Predicts Lethal Prostate Cancer. chr2 180692104 180916939 + Human SCHLAP1 ENST00000629145 26724257 CCAT2 cervical squamous cell cancer Expression Up-regulation of long non-coding RNA CCAT2 correlates with tumor metastasis and poor prognosis in cervical squamous cell cancer patients. chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 26722527 UCA1 gastric cancer Expression Plasma UCA1 levels could be a promising candidate of noninvasive biomarker for GC early diagnosis. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26722487 MALAT1 pre-eclampsia Regulation Under-expression of MALAT-1 during early placentation may be involved in the pathogenesis of preeclampsia. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26722461 H19 non-small cell lung cancer Regulation C-Myc-activated long non-coding RNAH19 downregulates miR-107 and promotes cell cycle progression of non-small cell lung cancer. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26722426 IRAIN non-small cell lung cancer Locus "These data identify IRAIN as a novel promoting gene, which plays a vital role in tumorigenesis of NSCLC." chr15 98645863 98651221 - Human IGF1R-AS NR_126453 26722412 CTD-2541M15 gastric cancer Regulation It may be associated with the progression and development of GC N/A N/A N/A N/A Human N/A N/A 26718650 UCA1 gastric cancer Regulation It may be associated with the progression and development of GC chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26718650 MEG3 gastric cancer Regulation It may be associated with the progression and development of GC chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26718650 HOTAIR nasopharyngeal carcinoma Regulation Long noncoding RNA Hotair mediated angiogenesis in nasopharyngeal carcinoma by direct and indirect signaling pathways. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26717040 HOTTIP hepatocellular carcinoma Regulation The miR-192/-204-HOTTIP axis might be an important molecular pathway during hepatic cell tumorigenesis. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 26710269 LOC389641 pancreatic ductal adenocarcinoma Regulation LOC389641 promotes PDAC progression and increases cell invasion by regulating E cadherin with the possible involvement of TNFRSF10A. chr8 23225221 23230926 + Human N/A NR_033928 26708505 CDKN2B-AS1 colorectal cancer Regulation ANRIL positively regulates the proliferation of HCT116 cells in two- and three-dimensional culture in a p15/p16-pRB pathway-independent manner. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 26708220 HOTAIR small cell lung cancer Regulation HOTAIR mediates chemoresistance of SCLC by regulating HOXA1 methylation and could be utilized as a potential target for new adjuvant therapies against chemoresistance. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26707824 GAS5 hepatocellular carcinoma Expression Decreased expression of long non-coding RNA GAS5 indicates a poor prognosis and promotes cell proliferation and invasion in hepatocellular carcinoma by regulating vimentin. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26707238 MIAT myocardial infarction N/A It plays an impoetant role in myocardial infarction chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 26707210 Gm15577 medulloblastoma Regulation "Gm15577 may modulate cerebellar granule cell proliferation and differentiation by targeting Negr1, and their dysfunctions or abnormal expression may be related to tumorigenesis of medulloblastoma." chr3 156903863 156920780 - Mouse N/A ENSMUST00000144350 26705043 MALAT1 breast cancer Expression "Malat1 represents an exciting therapeutic target, and Malat1 ASOs represent a potential therapy for inhibiting breast cancer progression." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26701265 MALAT1 liver fibrosis Regulation MALAT1 functions as a competing endogenous RNA to mediate Rac1 expression by sequestering miR-101b in liver fibrosis. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26697839 BALR-6 B-lymphoblastic leukemia Regulation BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia. N/A N/A N/A N/A Human N/A N/A 26694754 LINC01207 lung adenocarcinoma Regulation The long noncoding RNA LINC01207 promotes proliferation of lung adenocarcinoma. chr4 164754131 164803795 + Human N/A NR_038834 26693067 H19 glioma Regulation "H19 derived microRNA-675 may regulate giloma cell proliferation and migration through CDK6, and predict a poor prognosis of glioma patients." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26692922 MIR31HG gastric cancer Expression Decreased long noncoding RNA MIR31HG is correlated with poor prognosis and contributes to cell proliferation in gastric cancer. chr9 21454268 21559698 - Human hsa-lnc-31 NR_027054 26692098 uc.48+ diabetic neuropathic pain Regulation LncRNA uc.48+ is involved in diabetic neuropathic pain mediated by the P2X3 receptor in the dorsal root ganglia. N/A N/A N/A N/A Human N/A N/A 26686228 HOTTIP colorectal cancer Regulation HOTTIP is involved in the progression of CRC and may provide evidence for HOTTIP being a target for therapy of this disease. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 26678886 HOTAIRM1 pancreatic ductal adenocarcinoma Expression It may provide new potential molecular markers for diagnosis and treatment of PDAC. chr7 27096094 27100258 + Human HOXA-AS1; HOXA1-AS1; NCRNA00179 NR_038367 26676849 MALAT1 breast cancer Expression MALAT1 may be a target for TNBC therapy. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26676637 MEG3 glioma Regulation Epigenetic repression of long non-coding RNA MEG3 mediated by DNMT1 represses the p53 pathway in gliomas. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26676363 GAS5 type 2 diabetes mellitus Expression LncRNA GAS5 levels are correlated to prevalence of T2DM. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26675493 uc001ncr hepatocellular carcinoma Expression The serum expression of uc001ncr and AX800134 has potential as novel potential biomarker for the diagnosis of HCC N/A N/A N/A N/A Human N/A N/A 26674525 AX800134 hepatocellular carcinoma Expression The serum expression of uc001ncr and AX800134 has potential as novel potential biomarker for the diagnosis of HCC N/A N/A N/A N/A Human N/A N/A 26674525 C5T1 rheumatoid arthritis Locus "The identification of a novel lncRNA C5T1lncRNA that is fully located in the associated region and influences transcript levels of C5, a gene previously linked to RA pathogenesis." N/A N/A N/A N/A Human N/A N/A 26673966 ICR hepatocellular carcinoma Regulation "ICR specifically regulates CSC properties of ICAM-1(+)HCC cells and that ICR contributes to PVTT development. Therefore, ICR may be a promising target for HCC therapy." N/A N/A N/A N/A Human N/A N/A 26667486 ICAM-1 hepatocellular carcinoma Regulation "ICR specifically regulates CSC properties of ICAM-1(+)HCC cells and that ICR contributes to PVTT development. Therefore, ICR may be a promising target for HCC therapy." N/A N/A N/A N/A Human N/A N/A 26667486 H19 non-small cell lung cancer Expression C-Myc-regulated long non-coding RNA H19 indicates a poor prognosis and affects cell proliferation in non-small cell lung cancer. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26662571 GAS5 breast cancer Expression Plasma lncRNA GAS5 may have the potential to assess the surgical effects and prognosis for BC patients. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26662314 SNHG15 gastric cancer Expression Elevated lncRNA SNHG15 could be identified as a poor prognostic biomarker in GC and regulate cell invasion. chr7 44983028 44986660 - Human C7orf40; Linc-Myo1g; MYO1GUT NR_003697 26662309 MEG3 retinoblastoma Regulation MEG3 was a tumor suppressor by negatively regulating the activity of the Wnt/β-catenin pathway in the progression of retinoblastoma and might serve as a prognostic biomarker and molecular therapeutic target. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26662307 HOTAIR lung adenocarcinoma Regulation HOTAIR inhibition may represent a promising therapeutic option for suppressing lung ADC progression. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26658322 UCA1 non-small cell lung cancer Locus "UCA1 functions as an oncogene in NSCLC, acting mechanistically by upregulating ERBB4 in part through 'spongeing' miR-193a-3p." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26655272 FMR6 fragile X-associated premature ovarian insufficiency Regulation FMR6 may play a role in the pathogenesis of fragile X-associated premature ovarian insufficiency. N/A N/A N/A N/A Human N/A N/A 26652047 XLOC_011402 polycystic ovary syndrome Regulation It may contribute to the occurrence of PCOS and affect oocyte development. N/A N/A N/A N/A Human N/A N/A 26650608 ENST00000454271 polycystic ovary syndrome Regulation It may contribute to the occurrence of PCOS and affect oocyte development. chr1 169762929 169764648 - Human AL021940.1 ENST00000454271 26650608 ENST00000433673 polycystic ovary syndrome Regulation It may contribute to the occurrence of PCOS and affect oocyte development. chr2 127389130 127400580 + Human AC068282.1 ENST00000433673 26650608 LINC01828 polycystic ovary syndrome Regulation It may contribute to the occurrence of PCOS and affect oocyte development. chr2 67086446 67289244 + Human N/A NR_110564 26650608 ENST00000432431 polycystic ovary syndrome Regulation It may contribute to the occurrence of PCOS and affect oocyte development. chr2 144688413 144690185 - Human AC023128.1 ENST00000432431 26650608 MALAT1 glioma Regulation "MALAT1 plays an important role in regulating the expression of stemness markers and proliferation of SHG139S, and provide a new research direction to target the progression of GSCs." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26649728 lncRNA-HIF2PUT colorectal cancer Regulation LncRNA-HIF2PUT may be a regulator of HIF-2α and a mediator of CSCs in N/A N/A N/A N/A Human N/A N/A 26648739 MEG3 hepatocellular carcinoma Regulation ILF3 may participate in the anticancer regulation of MEG3 by interacting with MEG3. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26647875 FENDRR lung cancer Expression It may serve as a new biomarker for diagnosis of XWLC or a novel therapeutic target chr16 86474525 86508860 - Human FOXF1-AS1; TCONS_00024240; lincFOXF1; onco-lncRNA-21 NR_033925 26642714 SGO1-AS1 lung cancer Expression It may serve as a new biomarker for diagnosis of XWLC or a novel therapeutic target chr3 20174286 20186115 + Human SGOL1-AS1 NR_132785 26642714 NR_024118 rheumatoid arthritis Regulation Shikonin has disease modifying activity that is attributable to the inhibition of inflammatory response via lncRNA-NR024118. N/A N/A N/A N/A Human N/A N/A 26640499 XIST breast cancer Expression XIST and 53BP1 may be predictive biomarkers in BRCA1-like breast cancer chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 26637364 53BP1 breast cancer Expression XIST and 53BP1 may be predictive biomarkers in BRCA1-like breast cancer N/A N/A N/A N/A Human N/A N/A 26637364 LINC-ROR pancreatic cancer Expression ROR is a potential novel prognostic marker to predict the clinical outcome of pancreatic cancer patients after surgery and may be a rational target for therapy. chr18 57054571 57072119 - Human ROR; lincRNA-RoR NR_048536 26636540 IFNG-AS1 Hashimoto's thyroiditis Regulation Enhanced expression of lncRNA-IFNG-AS1 contributes to Th1 cell response in HT patients and may be involved in the pathogenesis of HT. chr12 67989445 68021327 + Human GS1-410F4.2; NEST; Tmevpg1 NR_104124 26634912 GAS5 breast cancer Regulation It is a pivotal tumor suppressor long noncoding RNA in human cancers. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26634743 GAS5 prostate cancer Regulation It is a pivotal tumor suppressor long noncoding RNA in human cancers. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26634743 GAS5 lung cancer Regulation It is a pivotal tumor suppressor long noncoding RNA in human cancers. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26634743 GAS5 colorectal cancer Regulation It is a pivotal tumor suppressor long noncoding RNA in human cancers. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26634743 RP11-284N8.3.1 ovarian cancer Expression It is a candidate biomarker for the prognosis of patients with OV and may enable a more accurate prediction of survival. N/A N/A N/A N/A Human N/A N/A 26631459 AC104699.1.1 ovarian cancer Expression It is a candidate biomarker for the prognosis of patients with OV and may enable a more accurate prediction of survival. N/A N/A N/A N/A Human N/A N/A 26631459 NONRATT021972 myocardial ischemic injury Regulation LncRNA NONRATT021972 involved the pathophysiologic processes mediated by P2X7 receptors in stellate ganglia after myocardial ischemic injury. N/A N/A N/A N/A Rat N/A N/A 26630943 FTX colorectal cancer Expression Long non-coding RNA FTX may be a potential biomarker for predicting the survival of colorectal cancer patients and might be a molecular target for treatment of human colorectal cancer. chrX 74028136 74293574 - Human LINC00182; MIR374AHG; NCRNA00182 NR_028379 26629053 HOTAIR acute myeloid leukemia Expression Overexpression of long non-coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26622861 DSCAM-AS1 breast cancer N/A It plays an important role in breast cancer chr21 40383083 40385358 + Human M41 NR_038900 26621851 MALAT1 glioma Regulation "Knockdown of MALAT1 resulted in the increased permeability of BTB, which might contribute to establishing potential therapeutic strategies for human gliomas." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26619802 AC002454.1 endometriosis Regulation AC002454.1 might induce cell cycle disorder by regulating CDK6 to participate in the pathogenesis of endometriosis. chr7 92836483 92917187 + Human AC002454.1 ENST00000419668 26618670 CDKN2B-AS1 coronary artery disease Regulation The newly identified TNF-α-NF-κB-ANRIL/YY1-IL6/8 pathway enhances understanding of the etiology of CAD and provides potential therapeutic target for treatment of CAD. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 26618242 DANCR colorectal cancer Regulation Over-expression of lncRNA DANCR is associated with advanced tumor progression and poor prognosis in patients with colorectal cancer. chr4 52712454 52714138 + Human AGU2; ANCR; KIAA0114; SNHG13; lncRNA-ANCR NR_024031 26617879 HOTTIP colorectal cancer Expression lncRNA HOTTIP overexpression maybe serves as an unfavorable prognosis predictor for CRC patients. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 26617875 HOTTIP osteosarcoma Expression Long non-coding RNA HOTTIP is up regulated and associated with poor prognosis in patients with osteosarcoma. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 26617868 MALAT1 gastric cancer Regulation JMJD1A-MALAT1-MAPK signaling might participate in the JMJD1A-induced cell proliferation of gastric cancer. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26617828 AK056155 Loeys-Dietz syndrome Regulation "AK056155 involved in the development of Loeys-Dietz syndrome through AKT/PI3K signaling pathway, it may provide a promising target gene to prevent LDS develop in to aortic aneurysm." N/A N/A N/A N/A Human N/A N/A 26617788 H19 ovarian cancer Regulation LncRNAH19 plays an important role in OC cell proliferation and contributes to a better understanding of the importance of dysregulated lncRNAs in OC progression. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26617715 MALAT1 hepatocellular carcinoma Expression "The plasma MALAT1 level is associated with liver damage, and has clinical utility for predicting development of HCC." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26614531 BX647187 prostate cancer Expression Hec1 is consistently overexpressed in human PCa and Hec1 is closely linked with human PCa progression through the meditator LncRNA BX647187 N/A N/A N/A N/A Human N/A N/A 26612002 NONHSAT037832 papillary thyroid carcinoma Expression Downregulation of long noncoding RNA NONHSAT037832 in papillary thyroid carcinoma and its clinical significance. N/A N/A N/A N/A Human N/A N/A 26611646 MEG3 prostate cancer Regulation Long Non-Coding RNA MEG3 Inhibits Cell Proliferation and Induces Apoptosis in Prostate Cancer. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26610246 NEAT1 esophageal squamous cell carcinoma Regulation Up regulation of the long non-coding RNANEAT1 promotes esophageal squamous cell carcinoma cell progression and correlates with poor prognosis. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 26609486 lnc-ZNF180-2 renal clear cell carcinoma Expression The long non-coding RNA lnc-ZNF180-2 is a prognostic biomarker in patients with clear cell renal cell carcinoma. N/A N/A N/A N/A Human N/A N/A 26609485 MEG3 diabetes mellitus Expression MEG3 may be a potential target and therapeutic strategy for diabetes. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26603935 linc-ITGB1 breast cancer Regulation Long non-coding RNA linc-ITGB1 promotes cell migration and invasion in human breast cancer. N/A N/A N/A N/A Human N/A N/A 26601916 BCYRN1 Alzheimer's disease Expression Overexpression of BC200 RNA leads to inadequate RNA delivery to the synapses and results in neurodegenerative processes of Alzheimer's disease and neoplastic changes in various groups of tissues. chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 26596549 PCA3 prostate cancer Expression This gene has been mainly exploited as an accurate diagnostic urine biomarker for Pca detection. chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 26594800 HOTAIR head and neck squamous cell carcinoma Regulation HOTAIR inhibition could be developed as a new therapeutic in HNSCC treatments. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26592246 NEAT1 glioma Expression This study supports NEAT1 as a potential prognostic predictor with its high expression in cancer tissues and its association with carcinogenesis and progression in glioma. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 26582084 HOTAIR breast cancer Regulation It plays a role as an oncogenic molecule in breast cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26577852 MALAT1 osteosarcoma Expression Long noncoding RNA MALAT1 as a potential therapeutic target in osteosarcoma. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26575981 MEG3 cervical cancer Regulation Long noncoding RNA MEG3 is downregulated in cervical cancer and affects cell proliferation and apoptosis by regulating miR-21. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26574780 RUNX1-IT1 gastric cancer Locus C21orF96 is an oncogenic lncRNA that promotes tumor progression and plays a pivotal role in the development of gastric cancer. chr21 35037925 35039426 - Human C21orf96 NR_026812 26567621 TSIX systemic sclerosis Regulation Long non-coding RNA TSIX is upregulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization. chrX 73792205 73829231 + Human LINC00013; NCRNA00013; XIST-AS; XIST-AS1; XISTAS NR_003255 26566700 LINC00472 breast cancer Regulation "LINC00472 is functionally a tumor suppressor, and that assessing its expression in breast tumors may have clinical implications in breast cancer management." chr6 71407864 71420745 - Human C6orf155 NR_121612 26564482 CRNDE ovarian cancer Expression CRNDE is a potential marker of poor prognosis in women with ovarian carcinomas chr16 54845189 54929189 - Human CRNDE ENST00000613942 26556866 LINC00917 intervertebral disc degeneration Regulation It might play important roles in the development of IDD chr16 86331850 86345679 - Human N/A NR_024406 26556537 CTD-2246P4.1 intervertebral disc degeneration Regulation It might play important roles in the development of IDD N/A N/A N/A N/A Human N/A N/A 26556537 CTC-523E23.5 intervertebral disc degeneration Regulation It might play important roles in the development of IDD chr19 34837889 34855304 + Human AC008555.2 ENST00000601776 26556537 RP4-639J15.1 intervertebral disc degeneration Regulation It might play important roles in the development of IDD chr7 157057709 157058514 - Human AC006967.2 ENST00000426169 26556537 RP11-363G2.4 intervertebral disc degeneration Regulation It might play important roles in the development of IDD N/A N/A N/A N/A Human N/A N/A 26556537 AK024171 intervertebral disc degeneration Regulation It might play important roles in the development of IDD chr7 N/A N/A + Human AC005082.1 N/A 26556537 MIR132 intervertebral disc degeneration Regulation It might play important roles in the development of IDD chr17 2049908 2050008 - Human MIRN132; miRNA132; mir-132 NR_029674 26556537 RP11-38F22.1 intervertebral disc degeneration Regulation It might play important roles in the development of IDD chr12 78326680 78359746 - Human LINC02424 ENST00000548512 26556537 MVIH breast cancer Expression Long non-coding RNA MVIH is associated with poor prognosis and malignant biological behavior in breast cancer. N/A N/A N/A N/A Human N/A N/A 26555546 NEAT1 colorectal cancer Expression Whole blood NEAT1 expression is a novel diagnostic and prognostic biomarker of overall survival in colorectal cancer. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 26552600 HOTAIR prostate cancer Expression "LncRNA HOTAIR is highly expressed in prostate cancer, which is associated with the growth and invasiveness of prostate cancer cells." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26552211 lncRNA-n336928 bladder cancer Expression "High expression of lncRNA-n336928 is associated with the progression of bladder cancer, and that lncRNA-n336928 might serve as a biomarker for prognosis of bladder cancer." N/A N/A N/A N/A Human N/A N/A 26551459 UCA1 hepatocellular carcinoma Expression LncRNA-UCA1 and lncRNA-WRAP53 upregulation may serve as novel serum biomarkers for HCC diagnosis and prognosis. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26551349 WRAP53 hepatocellular carcinoma Expression LncRNA-WRAP53 was significant independent prognostic markers in relapse-free survival. N/A N/A N/A N/A Human N/A N/A 26551349 GAS5 breast cancer Regulation "Notch-1, which identified the most relevant lncRNA GAS5 in breast cancer, promotes breast cancer cells proliferation by regulating LncRNA GAS5." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26550436 HEIH hepatocellular carcinoma Regulation HEIH plays an important role in the invasion of hepatocellular carcinoma cell. chr5 180829954 180831618 - Human HCCAT2; LINC-HEIH; LINC00848; lncRNA-HEIH NR_045680 26550214 HULC hepatocellular carcinoma Regulation HULC could promote proliferation of hepatoma cells. chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 26550214 UCA1 prostate cancer Regulation Long non-coding RNA UCA1 contributes to the progression of prostate cancer and regulates proliferation through KLF4 KRT6/13 signaling pathway. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26550172 HOTAIR colorectal cancer Regulation Knockdown of long non-coding RNA HOTAIR inhibits proliferation and invasiveness and improves radiosensitivity in colorectal cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26549670 MIR31HG pancreatic ductal adenocarcinoma Locus "MIR31HG functions as an oncogenic lncRNA that promotes tumor progression, and miR-193b targets not only protein-coding genes but also the lncRNA, MIR31HG." chr9 21454268 21559698 - Human hsa-lnc-31 NR_027054 26549028 BC032469 gastric cancer Regulation "Long noncoding RNA BC032469, a novel competing endogenous RNA, upregulates hTERT expression by sponging miR-1207-5p and promotes proliferation in gastric cancer." N/A N/A N/A N/A Human N/A N/A 26549025 GAS5 bladder cancer Regulation "GAS5 was able to suppress bladder cancer cell proliferation, at least partially, by suppressing the expression of CCL1." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26548923 HOTAIR breast cancer Mutation "Genetic variant rs920778 in HOTAIR significantly increased the risk of BC, and it may have apparent interaction with reproductive factors in the progression on BC." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26547792 PVT1 acute promyelocytic leukemia Expression Overexpression of the long non-coding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 26545364 UCA1 bladder cancer Expression LncRNA-UCA1 might act as a promising therapeutic target for the invasion and metastasis of bladder cancer. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26544536 MEG8 temple syndrome Regulation The differentially methylated region of MEG8 is hypermethylated in patients with Temple syndrome. chr14 100894770 100906968 + Human Bsr; Irm; LINC00024; NCRNA00024; Rian; SNHG23; SNHG24 NR_146000 26541061 HULC liver cancer Regulation HULC promotes tumor angiogenesis in liver cancer through miR 107/E2F1/SPHK1 signaling. chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 26540633 LINC01419 hepatocellular carcinoma Regulation LINC01419 and AK021443 regulate cell cycle genes chr8 83403758 83408900 + Human LVCAT7; TCONS_00014497 NR_122034 26540467 AK021443 hepatocellular carcinoma Regulation LINC01419 and AK021443 regulate cell cycle genes N/A N/A N/A N/A Human N/A N/A 26540467 AF070632 hepatocellular carcinoma Regulation "AF070632 is associated with cofactor binding, oxidation-reduction and carboxylic acid catabolic process." N/A N/A N/A N/A Human N/A N/A 26540467 CYTOR hepatocellular carcinoma Regulation LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway chr2 87455455 87521518 + Human C2orf59; LINC00152; NCRNA00152 NR_024204 26540343 PICSAR testicular embryonal carcinoma Regulation Downregulation of miR-320a/383-sponge like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation. chr21 44999208 45004727 - Human C21orf113; LINC00162; NCRNA00162; NLC1-C; NLC1C; PRED74 NR_024089 26539909 CYTOR gastric cancer Regulation Linc00152 could promote tumor growth through EGFR-mediated PI3K/AKT pathway which may serve as potential targets for therapy in the future. chr2 87455455 87521518 + Human C2orf59; LINC00152; NCRNA00152 NR_024204 26538117 LOWEG gastric cancer Regulation A novel long noncoding RNA-LOWEG is low expressed in gastric cancer and acts as a tumor suppressor by inhibiting cell invasion. N/A N/A N/A N/A Human N/A N/A 26537802 PRNCR1 colorectal cancer Regulation PRNCR1 promotes the proliferation of CRC cells and is a potential oncogene of CRC. chr8 127079874 127092595 + Human CARLo-3; PCAT8 NR_109833 26530130 HOTAIR cervical cancer Regulation Propofol promotes cell apoptosis via inhibiting HOTAIR mediated mTOR pathway in cervical cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26523512 MALAT1 oral squamous cell carcinoma Expression MALAT1 is an important prognostic factor and therapeutic target for OSCC. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26522444 HOTAIR ovarian cancer Expression Overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/β-catenin pathway in human ovarian cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26518770 PVT1 bladder cancer Regulation Tetracycline-inducible shRNA targeting long non-coding RNA PVT1 inhibits cell growth and induces apoptosis in bladder cancer cells. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 26517688 MALAT1 prostate cancer Regulation MALAT1 may be a crucial RNA cofactor of EZH2 and that theEZH2-MALAT1 association may provide a new avenue for development new strategies for treatment of CRPC chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26516927 UCA1 liver cancer Regulation Long noncoding RNA CUDR will help in the development of new liver cancer therapeutic and diagnostic approaches. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26513297 Malat1 diabetes mellitus Regulation Down-regulation of lncRNA MALAT1 reduces cardiomyocyte apoptosis and improves left ventricular function in diabetic rats. chr19 5795690 5802671 - Mouse 2210401K01Rik; 9430072K23Rik; AI647968; Neat2 NR_002847 26512840 GAS5 endometrial cancer Regulation GAS5 plasmid may reverse this regulation effect in endometrial cancer cells. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26511107 ZFAS1 colorectal cancer Regulation Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer. chr20 49278178 49289260 + Human C20orf199; HSUP1; HSUP2; NCRNA00275; ZNFX1-AS1 NR_036658 26506418 GAS5 ovarian cancer Regulation "GAS5 inhibits EOC cell proliferation, migration and invasion, and promotes cell apoptosis. GAS5 can serve as a novel therapeutic target in patients with EOC." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26503132 PCA3 prostate cancer Expression It can use as a tumor marker for PCa and may be an attractive novel therapeutic target for the diagnosis and treatment of PCa. chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 26503110 PCATs prostate cancer Expression It can use as a tumor marker for PCa and may be an attractive novel therapeutic target for the diagnosis and treatment of PCa. N/A N/A N/A N/A Human N/A N/A 26503110 SCHLAP1 prostate cancer Expression It can use as a tumor marker for PCa and may be an attractive novel therapeutic target for the diagnosis and treatment of PCa. chr2 180692104 180916939 + Human SCHLAP1 ENST00000629145 26503110 SPRY4-IT1 prostate cancer Expression It can use as a tumor marker for PCa and may be an attractive novel therapeutic target for the diagnosis and treatment of PCa. chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 26503110 TRPM2-AS prostate cancer Expression It can use as a tumor marker for PCa and may be an attractive novel therapeutic target for the diagnosis and treatment of PCa. chr21 44414590 44425563 - Human TRPM2-AS1 NR_109964 26503110 TUG1 osteosarcoma Expression Upregulation of long non-coding RNA TUG1 correlates with poor prognosis and disease status in osteosarcoma. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 26499949 CPS1-IT1 intrahepatic cholangiocarcinoma Expression CPS1 and CPS1-IT1 may be potential prognostic indicators for patients with ICC. chr2 210617571 210619876 + Human CPS1-IT; CPS1IT; CPS1IT1; PRO0132 NR_002763 26499888 HOTAIR ovarian cancer Regulation HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26497652 MALAT1 esophageal squamous cell carcinoma Regulation "MALAT-1 knockdown induced a decrease in proliferation enhanced apoptosis, inhibited migration/invasion, and reduced colony formation and led to cell cycle arrest at the G2/M phase." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26493997 CECR7 hepatocellular carcinoma Expression It was found to be significantly associated with overall survival chr22 17036570 17058792 + Human SAHL1 NR_015352 26492393 LINC00346 hepatocellular carcinoma Expression It was found to be significantly associated with overall survival chr13 110863987 110870308 - Human C13orf29; NCRNA00346 NR_027701 26492393 MAPKAPK5-AS1 hepatocellular carcinoma Expression It was found to be significantly associated with overall survival chr12 111839769 111842902 - Human C12orf47 NR_015404 26492393 LOC338651 hepatocellular carcinoma Expression It was found to be significantly associated with overall survival N/A N/A N/A N/A Human N/A N/A 26492393 FLJ90757 hepatocellular carcinoma Expression It was found to be significantly associated with overall survival N/A N/A N/A N/A Human N/A N/A 26492393 LOC283663 hepatocellular carcinoma Expression It was found to be significantly associated with overall survival N/A N/A N/A N/A Human N/A N/A 26492393 PVT1 non-small cell lung cancer Expression Long non-coding RNA PVT1 as a novel biomarker for diagnosis and prognosis of non-small cell lung cancer chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 26490983 ATB colon cancer Regulation LncRNA-ATB mediated E-cadherin repression promotes the progression of colon cancer and predicts poor prognosis. N/A N/A N/A N/A Human N/A N/A 26487301 SNHG12 osteosarcoma Regulation Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes cell proliferation and migration by upregulating angiomotin gene expression in human osteosarcoma cells. chr1 28578538 28581854 - Human ASLNC04080; C1orf79; LINC00100; NCRNA00100; PNAS-123 NR_024127 26486328 TRPM2-AS prostate cancer Regulation The long non-coding RNA (ncRNA) TRPM2 AS is a key regulator of survival in prostate cancer chr21 44414590 44425563 - Human TRPM2-AS1 NR_109964 26484139 MALAT1 nasopharyngeal carcinoma Regulation "MALAT1 regulated CSC activity and radioresistance by modulating miR 1/slug axis, which indicated that MALAT1 could act as a therapeutic target for NPC patients." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26482776 H19 non-small cell lung cancer Regulation "H19 is involved in the oncogenesis of NSCLC, and H19 may be a potential diagnostic and target for new therapies in patients with NSCLC." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26482621 GAS5 head and neck cancer Expression Circulating GAS5 could be a biomarker in predicting treatment response in HNC patients. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26482616 HOTAIR pancreatic ductal adenocarcinoma Regulation "HOTAIR can affect the radiosensitivity of PDAC cells partly via regulating the expression of WIF-1, and HOTAIR-WIF-1 axis is a potential target for PDAC radiotherapy." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26482614 ATB pancreatic cancer Regulation LncRNA-ATB may play a critical role in pancreatic cancer progression and prognosis and may serve as a potential prognostic biomarker in pancreatic cancer patients. N/A N/A N/A N/A Human N/A N/A 26482611 MEG3 non-small cell lung cancer Regulation Meg3 and miR-3163 may coordinate suppression of translation of Skp2 mRNA in NSCLC cells to inhibit NSCLC cell growth. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26482610 MIR100HG neuroblastoma Regulation "Identification of linc-NeD125, a novel long non coding RNA that hosts miR-125b-1 and negatively controls proliferation of human neuroblastoma cells." chr11 122089103 122203062 - Human AGD1; linc-NeD125; lncRNA-N2 NR_137175 26480000 PACERR osteosarcoma Regulation PACER promotes proliferation and metastasis of osteosarcoma cells by activating the COX-2 gene and its own expression was influenced by DNA methylation. chr1 186680654 186681446 + Human PACER; PTGS2-AS1 NR_125801 26476537 MALAT1 diabetic cardiomyopathy Regulation Involvement of long noncoding RNA MALAT1 in the pathogenesis of diabetic cardiomyopathy. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26476026 HNF1A-AS1 gastric cancer Regulation "lncRNA HNF1A-AS1 may be a regulator of GC, and thus, it may have potential as a novel biomarker and treatment target for this type of cancer." chr12 120969838 120972292 - Human C12orf27; NCRNA00262 NR_024345 26472090 HOTAIR bladder cancer Regulation Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26469956 CCAT1 breast cancer Expression Overexpression of long non-coding RNA CCAT1 is a novel biomarker of poor prognosis in patients with breast cancer. chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 26464701 SPRY4-IT1 glioma Regulation Knockdown of SPRY4-IT1 could inhibit epithelial mesenchymal transition (EMT) phenotype in glioma cells chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 26464658 UCA1 breast cancer Regulation Macrophage could promote invasiveness of breast cancer cells by enhancing expression of lncRNA UCA1. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26464647 FOXC2-AS1 osteosarcoma Regulation It may play a critical role in doxorubicin resistance of OS by interacting with important genes chr16 86565145 86567761 - Human ODRUL NR_125795 26464619 FENDRR osteosarcoma Regulation It may play a critical role in doxorubicin resistance of OS by interacting with important genes chr16 86474525 86508860 - Human FOXF1-AS1; TCONS_00024240; lincFOXF1; onco-lncRNA-21 NR_033925 26464619 AFAP1-AS1 non-small cell lung cancer Regulation LncRNA AFAP1-AS1 was up-regulated in NSCLC tissues and it could be an independent prognostic indicator for NSCLC patients. chr4 7754090 7778928 + Human AFAP1-AS; AFAP1AS NR_026892 26463625 WT1-AS hepatocellular carcinoma Regulation WT1-AS may function as a tumor suppressor in HCC by reversing the oncogenic effects of WT1. chr11 32435518 32458769 + Human WIT-1; WIT11; WT1AS; WT1-AS NR_120546 26462627 MCHR2-AS1 psychiatric disease N/A It plays an important role in psychiatric patients chr6 99994038 100076419 + Human N/A NR_038384 26461262 MALAT1 renal clear cell carcinoma Regulation The inhibition of MALAT1 expression may be a promising strategy for KIRC therapy. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26461224 TDRG1 aplastic anemia Regulation FGF1 induces the proliferation of BMSCs in patients with AA via promoting acetylation in lncRNA of the TDRG1 gene promoter. chr6 40378424 40379892 + Human LINC00532 NR_024015 26460236 PVT1 hematological malignancies Locus The fusion genes involving lincRNAs potentially play as-yet-unknown oncogenic functional roles. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 26458445 CCDC26 hematological malignancies Locus The fusion genes involving lincRNAs potentially play as-yet-unknown oncogenic functional roles. chr8 129351694 129680239 - Human RAM NR_130917 26458445 HOTAIR bladder cancer Expression "HOTAIR expression has prognostic value for bladder cancer progression, recurrence, and survival and suggest that HOTAIR plays active roles in modulating the cancer epigenome, becoming an interesting candidate as a target for cancer diagnosis and therapy." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26457124 SPRY4-IT1 non-small cell lung cancer Expression "Circulating SPRY4-IT1, ANRIL, and NEAT might serve as a predictor for the early warning of non-small-cell lung cancer." chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 26453113 CDKN2B-AS1 non-small cell lung cancer Expression "Circulating SPRY4-IT1, ANRIL, and NEAT might serve as a predictor for the early warning of non-small-cell lung cancer." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 26453113 NEAT1 non-small cell lung cancer Expression "Circulating SPRY4-IT1, ANRIL, and NEAT might serve as a predictor for the early warning of non-small-cell lung cancer." chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 26453113 lncTCF7 hepatocellular carcinoma Regulation "Long noncoding RNA lncTCF7, induced by IL-6/STAT3 transactivation, promotes hepatocellular carcinoma aggressiveness through epithelial-mesenchymal transition." N/A N/A N/A N/A Human N/A N/A 26452542 NONHSAG011351 type 1 diabetes mellitus Regulation ERBB3 whose locus associated lncRNA (NONHSAG011351) was found to be expressed in human islets，may constitute novel targets to prevent β-cell destruction in T1D. N/A N/A N/A N/A Human N/A N/A 26450151 WT1-AS gastric cancer Regulation Decreased expression of long non-coding RNA WT1-AS promotes cell proliferation and invasion in gastric cancer. chr11 32435518 32458769 + Human WIT-1; WIT11; WT1AS; WT1-AS NR_120546 26449525 CDKN2B-AS1 bladder cancer Locus ANRIL possibly serves as anoncogene in bladder cancer and regulates bladder cancer cell proliferation and apoptosis through the intrinsic apoptosis pathway. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 26449463 ENST00000438550 nasopharyngeal carcinoma Expression ENST00000438550 expression was demonstrated to be significantly correlated with NPC disease progression. chrY 12244752 12245457 + Human RPS24P1 ENST00000438550 26448942 FAM30A gallbladder cancer Regulation KIAA0125 promoted the migration and invasion of GBC cells and could serve as a potential therapeutic target in advanced GBC. chr14 105917979 105932642 + Human C14orf110; HSPC053; KIAA0125 NR_026800 26448925 HOTTIP pancreatic cancer Expression Increased HOTTIP-005 and RP11-567G11.1 expression were poor prognostic factors for patients with PC chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 26447755 RP11-567G11.1 pancreatic cancer Expression Increased HOTTIP-005 and RP11-567G11.1 expression were poor prognostic factors for patients with PC chr3 187448845 187449450 + Human LINC02041 ENST00000440726 26447755 GAS5 liver fibrosis Regulation "GAS5 increased the level of p27 protein by functioning as a competing endogenous RNA for miR-222, thereby inhibiting the activation and proliferation of HSCs." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26446789 MEG3 hepatocellular carcinoma Regulation MEG3 functions as a tumor suppressor in hepatoma cells through interacting with p53 protein to activate p53-mediated transcriptional activity and influence the expression of partial p53 target genes. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26444285 CCAT2 breast cancer Regulation Long noncoding RNA CCAT2 promotes breast tumor growth by regulating the Wnt signaling pathway. chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 26442763 TMEVPG1 Sjögren syndrome Regulation Upregulation of long noncoding RNA TMEVPG1 enhances T helper type 1 cell response in patients with Sjögren's syndrome. N/A N/A N/A N/A Human N/A N/A 26440590 SNHG5 melanoma Expression "Serum long non-coding RNA, snoRNA host gene 5 level as a new tumor marker of malignant melanoma." chr6 85677007 85678733 - Human C6orf160; LINC00044; NCRNA00044; U50HG; bA33E24.2 NR_003038 26440365 UCA1 breast cancer Regulation Long noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR-143. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26439035 HOTAIRM1 acute myeloid leukemia Locus "The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature." chr7 27096094 27100258 + Human HOXA-AS1; HOXA1-AS1; NCRNA00179 NR_038367 26436590 CCAT1 hepatocellular carcinoma Regulation CARLo-5 promotes proliferation and metastasis of HCC and potentially emerged as a novel therapeutic target. chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 26433964 HOXA11-AS ovarian cancer Regulation "HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer." chr7 27185408 27189293 + Human HOXA-AS51; HOXA11AS; HOXA11S; NCRNA00076; HOXA11-AS NR_002795 26430965 PVT1 thyroid cancer Regulation Long noncoding RNA PVT1 modulates thyroid cancer cell proliferation by recruiting EZH2 and regulating thyroid-stimulating hormone receptor (TSHR). chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 26427660 LINC01016 breast cancer Regulation "LINC01016 and LINC00160 are direct transcriptional targets of ERα, correlate with Erα expression in clinical samples, and show prognostic significance in relation to breast cancer survival." chr6 33889511 33896907 - Human N/A NR_038989 26426411 LINC00160 breast cancer Regulation "LINC01016 and LINC00160 are direct transcriptional targets of ERα, correlate with Erα expression in clinical samples, and show prognostic significance in relation to breast cancer survival." chr21 34723807 34737182 - Human C21orf52; NCRNA00160 NR_024351 26426411 lncRNA-Hh breast cancer Regulation "LncRNA-Hh silence in Twist-positive breast cells attenuates the activated Shh-GLI1 signaling and decreases the CSC-associated SOX and OCT4 levels, thus reduces the MFE and tumorigenesis of transplanted tumor." N/A N/A N/A N/A Human N/A N/A 26418365 lncRNA-DLEU1 breast cancer Expression LncRNA-DLEU1 was highly expressed in the MCF-7 cells in breast cancer N/A N/A N/A N/A Human N/A N/A 26416600 H19 embryonal carcinoma Regulation H19 oncogenicity in hEC cells is mediated through the regulation of the pluripotency state. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26415227 HOTAIR prostate cancer Regulation LncRNA HOTAIR Enhances the Androgen Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26411689 TP73-AS1 multiple myeloma N/A KIAA0495 methylation appeared unimportant in the pathogenesis or progression of myeloma. chr1 3735984 3747373 - Human KIAA0495; PDAM NR_033709 26410378 SOX2-OT breast cancer Expression It can be used as a potential cancer biomarker chr3 181056680 181742228 + Human NCRNA00043; SOX2OT NR_075089 26409453 PTPRG-AS1 breast cancer Expression It can be used as a potential cancer biomarker chr3 62261819 62318947 - Human N/A NR_038282 26409453 RASSF1-AS1 breast cancer Expression It can be used as a potential cancer biomarker chr3 50337511 50338300 + Human ANRASSF1 NR_109831 26409453 CDKN2B-AS1 breast cancer Expression It can be used as a potential cancer biomarker chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 26409453 CDKN2B-AS1 non-small cell lung cancer Regulation Long Noncoding RNA ANRIL Regulates Proliferation of Non-small Cell Lung Cancer and Cervical Cancer Cells. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 26408699 CDKN2B-AS1 cervical cancer Regulation Long Noncoding RNA ANRIL Regulates Proliferation of Non-small Cell Lung Cancer and Cervical Cancer Cells. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 26408699 FOXC2-AS1 osteosarcoma Regulation LncRNA ODRUL may act as a pro-doxorubicin-resistant molecule through inducing the expression of the classical multidrug resistance-related ABCB1 gene in osteosarcoma cells chr16 86565145 86567761 - Human ODRUL NR_125795 26408180 MALAT1 esophageal squamous cell carcinoma Expression MALAT1 expression may serve as a predictive marker for middle thoracic ESCC patients who have been received radical resection. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26406400 GAS5 hepatocellular carcinoma Regulation Long noncoding RNA GAS5 suppresses the migration and invasion of hepatocellular carcinoma cells via miR-21. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26404135 MALAT1 cervical cancer Expression High MALAT1 expression predicts a poor prognosis of cervical cancer and promotes cancer cell growth and invasion. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26400521 RP11-397D12.4 non-small cell lung cancer Expression "RP11-397D12.4, AC007403.1,and ERICH1 AS1 may be potential biomarkers for predicting the tumorigenesis of NSCLC in the future" chr9 37383178 37384434 - Human LINC01627 ENST00000452923 26393913 AC007403.1 non-small cell lung cancer Expression "RP11-397D12.4, AC007403.1,and ERICH1 AS1 may be potential biomarkers for predicting the tumorigenesis of NSCLC in the future" chr2 66921510 66922457 - Human LINC01628 ENST00000427579 26393913 ERICH1-AS1 non-small cell lung cancer Expression "RP11-397D12.4, AC007403.1,and ERICH1 AS1 may be potential biomarkers for predicting the tumorigenesis of NSCLC in the future" N/A N/A N/A N/A Human N/A N/A 26393913 DBH-AS1 hepatocellular carcinoma Regulation HBx-related long non-coding RNA DBH AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma. chr9 133654587 133657408 - Human NCRNA00118 NR_102735 26393879 HOXA-AS2 gastric cancer Regulation Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression. chr7 27121919 27128760 + Human HOXA3as NR_122069 26384350 HOTAIR gastric cancer Expression SNP rs4759314 of HOTAIR acts as a potential biomarker for predicting gastric cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26384301 UCA1 lung cancer Regulation Upregulated lncRNA-UCA1 contributes to progression of lung cancer and is closely related to clinical diagnosis as a predictive biomarker in plasma. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26380024 NBAT1 breast cancer Regulation NBAT1 suppresses breast cancer metastasis by regulating DKK1 via PRC2. chr6 22134602 22147193 - Human CASC14; NBAT-1 NR_034143 26378045 H19 liver cancer Regulation miR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26376677 SNHG3 hepatocellular carcinoma Expression SNHG3 correlates with malignant status and poor prognosis in hepatocellular carcinoma. chr1 28505943 28510892 + Human NCRNA00014; RNU17C; RNU17D; U17HG; U17HG-A; U17HG-AB NR_036473 26373735 UCA1 bladder cancer Regulation Long non-coding RNA UCA1 promotes glutamine metabolism by targeting miR-16 in human bladder cancer. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26373319 GAS5 glioma Expression the introduction of Gas5 by plasmid transfection increased the expression of tumor suppressor Bcl-2 modifying factor (bmf) and Plexin C1 via directly targeting and reducing the expression of miR-222. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26370254 HOTAIR breast cancer Regulation LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26364613 LOC554202 colorectal cancer Regulation Loc554202 may play an important role in the progression of CRC and could be a candidate prognostic biomarker or a target for new cancer therapies. N/A N/A N/A N/A Human N/A N/A 26362196 HULC hepatocellular carcinoma Expression Both plasma levels of HULC and Linc00152 achieve a fine diagnostic accuracy in diagnosing ontogenesis and metastasis of HCC and may act as novel biomarkers for HCC. chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 26356260 CYTOR hepatocellular carcinoma Expression Both plasma levels of HULC and Linc00152 achieve a fine diagnostic accuracy in diagnosing ontogenesis and metastasis of HCC and may act as novel biomarkers for HCC. chr2 87455455 87521518 + Human C2orf59; LINC00152; NCRNA00152 NR_024204 26356260 H19 breast cancer Regulation H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26353930 MALAT1 hepatocellular carcinoma Regulation Sp1 cooperates with Sp3 to upregulate MALAT1 expression in human hepatocellular carcinoma. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26352013 MINCR Burkitt lymphoma Regulation MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells. chr8 143280155 143281700 - Human LINC01604 NR_120682 26351698 TUSC7 acute myeloid leukemia Expression Overexpression of the LSAMP and TUSC7 genes in acute myeloid leukemia following microdeletion/duplication of chromosome 3. chr3 116709788 116717040 + Human LINC00902; LSAMP-AS1; LSAMP-AS3; LSAMPAS3; NCRNA00295 NR_015391 26345353 HOTAIR ovarian cancer Expression Overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/β-catenin pathway in human ovarian cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26341496 PCGEM1 osteoarthritis Regulation PCGEM1 stimulates proliferation of osteoarthritic synoviocytes by acting as a sponge for miR-770. chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 26340084 XIST non-small cell lung cancer Expression Increased serum XIST and HIF1A-AS1 could be used as a predictive biomarker for NSCLC screening chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 26339353 HIF1A-AS1 non-small cell lung cancer Expression Increased serum XIST and HIF1A-AS1 could be used as a predictive biomarker for NSCLC screening chr14 61681041 61695823 - Human 5'aHIF-1A; 5'aHIF1alpha NR_047116 26339353 HOTAIR lung cancer Regulation Radiotherapy induced Lewis lung cancer cell apoptosis via inactivating β-catenin mediated by upregulated HOTAIR. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26339352 TUG1 hepatocellular carcinoma Regulation Long non-coding RNA TUG1 is up regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 26336870 GAS5 lung adenocarcinoma N/A It plays critical roles in lung adenocarcinoma. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26336799 LINC00982 gastric cancer Regulation Upregulated expression of long non coding RNA LINC00982 regulates cell proliferation and its clinical relevance in patients with gastric cancer. chr1 3059617 3067725 - Human N/A NR_015440 26334618 NALT1 acute lymphoblastic leukemia Regulation LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia. chr9 136547842 136549744 + Human LINC01573; MIR4674HG; NALT NR_121577 26330272 ZNRD1-AS1 cervical cancer Expression Expression quantitative trait loci in long non-coding RNA ZNRD1-AS1 influence cervical cancer development. N/A N/A N/A N/A Human N/A N/A 26328261 LINC01617 colorectal cancer Expression It might be the potential biomarker for the tumorigenesis prediction of CRC in the future. chr8 73879010 73904730 + Human C8orf23; NCRNA00249; XLOC_006844 NR_147034 26328256 LOC152578 colorectal cancer Expression It might be the potential biomarker for the tumorigenesis prediction of CRC in the future. N/A N/A N/A N/A Human N/A N/A 26328256 LINC01507 colorectal cancer Expression It might be the potential biomarker for the tumorigenesis prediction of CRC in the future. chr9 79824530 80034555 + Human XLOC_000303 NR_121213 26328256 HOTAIR gastric adenocarcinoma Expression HOTAIR is a predictive and prognostic biomarker for patients with advanced gastric adenocarcinoma receiving fluorouracil and platinum combination chemotherapy. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26328013 RP11-457M11.2 lung adenocarcinoma Expression It could serve as a biomarker for diagnosis N/A N/A N/A N/A Human N/A N/A 26325208 HOTAIR breast cancer Regulation It plays an important roles in breast tumourigenesis chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26323944 H19 breast cancer Regulation It plays an important roles in breast tumourigenesis chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26323944 KCNQ1OT1 breast cancer Regulation It plays an important roles in breast tumourigenesis chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 26323944 BANCR papillary thyroid carcinoma Regulation BANCR may contribute to the tumorigenesis of PTC through regulation of cyclin D1 and TSHR chr9 69296681 69307056 - Human LINC00586 NR_047671 26323637 LSINCT5 chronic heart failure Regulation Increased B-type-natriuretic peptide promotes myocardial cell apoptosis via the B-type-natriuretic peptide/long non coding RNA LSINCT5/caspase-1/interleukin 1β signaling pathway. chr5 2712591 2715237 - Human N/A NR_145480 26323562 MEG3 hepatocellular carcinoma Regulation Dendrosomal curcumin increases expression of the long non-coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26321746 TUG1 bladder cancer Regulation Double-negative feedback loop between long non-coding RNA TUG1 and miR-145 promotes epithelial to mesenchymal transition and radioresistance in human bladder cancer cells. chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 26318860 n336934 Alzheimer's disease Expression Upregulated lncRNA n336934 is linked to cholesterol homeostasis. N/A N/A N/A N/A Human N/A N/A 26318290 LINC01616 Alzheimer's disease Regulation LncRNA n341006 is associated with protein ubiquitination pathway chr11 29980120 29982393 - Human n341006 NR_132652 26318290 HULC hepatocellular carcinoma Regulation "Knockdown of Sp transcription factors and HULC by RNAi showed that they play important roles in HCC cell proliferation, survival and migration." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 26317792 NEAT1 colorectal cancer Expression NEAT1 may serve as an indicator of tumor recurrence and prognosis of colorectal cancer. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 26314847 MALAT1 cervical cancer Regulation Long non-coding RNA MALAT1 modulates radiosensitivity of HR-HPV+ cervical cancer via sponging miR-145. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26311052 LINC00675 pancreatic ductal adenocarcinoma Expression Linc00675 is a novel marker of short survival and recurrence in patients with pancreatic ductal adenocarcinoma. chr17 10794913 10804099 - Human N/A NR_036581 26309360 LOXL1-AS1 exfoliation syndrome Expression Dysregulation of its expression by genetic risk variants plays a key role in XFS pathogenesis. chr15 73917468 73928248 - Human N/A NR_040066 26307087 FER1L4 gastric cancer Regulation The lncRNA FER1L4 acts as a competing endogenous RNA (ceRNA) to regulate the expression of PTEN by taking up miR-106a-5p in gastric cancer. chr20 35558737 35607562 - Human FER1L4 ENST00000615531 26306906 SPRY4-IT1 lung cancer Expression Over expression of SPRY4-IT1 enhanced the invasion and migration of A549 cells. chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 26302345 AB073614 ovarian cancer Regulation A long noncoding RNA AB073614 promotes tumorigenesis and predicts poor prognosis in ovarian cancer. N/A N/A N/A N/A Human N/A N/A 26299803 BANCR colorectal cancer Regulation Fentanyl inhibits the invasion and migration of colorectal cancer cells via inhibiting the negative regulation of Ets-1 on BANCR. chr9 69296681 69307056 - Human LINC00586 NR_047671 26296467 LUADT1 lung adenocarcinoma Locus "LUADT1 is an oncogenic lncRNA that regulates LUAD progression, suggesting that dysregulated lncRNAs may serve as key regulatory factors in LUAD progression." chr6 147158925 147180992 + Human N/A NR_132442 26291312 GAPLINC gastric cancer Regulation Long Noncoding RNA GAPLINC Regulates CD44-Dependent Cell Invasiveness and Associates with Poor Prognosis of Gastric Cancer. chr18 3466250 3478978 + Human LINC01540 NR_110428 26286476 MEG3 pituitary adenoma Regulation MEG3 is a lncRNA tumor suppressor in the pituitary and its inactivation contributes to NFA development chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26284494 MALAT1 congenital microtia Regulation LncRNA of MALAT1 may play important roles in the development of the external ear. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26282502 PCAT5 prostate cancer Locus "PCAT5 is a novel oncogenic lncRNA in ERG-positive prostate cancers, with implications for defining CRPC biomarkers and new therapeutic interventions." chr10 35778302 35800920 + Human LINC01452; TPCAT-10-36067 NR_110138 26282172 ABHD11-AS1 gastric cancer Expression Gastric juice ABHD11-AS1 may be a potential biomarker in the screening of gastric cancer. chr7 73735069 73736000 + Human LINC00035; NCRNA00035; WBSCR26 NR_026690 26280398 GAS5 gastric cancer Regulation GAS5 plays in the molecular etiology of GC and suggest a potential of GAS5 as a new therapeutic target for GC treatment. chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26278580 FTH1P3 oral squamous cell carcinoma Regulation "LncRNAs FTH1P3, PDIA3F and GTF2IRD2P1 may responsible for progression and metastasis of OSCC via targeting MMP1, MMP3, MMP9, PLAU and IL8 which are key regulators of tumorigenesis." chr2 27392784 27393367 - Human FTH1P3 ENST00000394290 26276270 PDIA3F oral squamous cell carcinoma Regulation "LncRNAs FTH1P3, PDIA3F and GTF2IRD2P1 may responsible for progression and metastasis of OSCC via targeting MMP1, MMP3, MMP9, PLAU and IL8 which are key regulators of tumorigenesis." N/A N/A N/A N/A Human N/A N/A 26276270 GTF2IRD2P1 oral squamous cell carcinoma Regulation "LncRNAs FTH1P3, PDIA3F and GTF2IRD2P1 may responsible for progression and metastasis of OSCC via targeting MMP1, MMP3, MMP9, PLAU and IL8 which are key regulators of tumorigenesis." chr7 73242751 73280119 - Human GTF2IRD2P1 ENST00000449689 26276270 MALAT1 breast cancer Regulation Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26275461 H19 glioblastoma Regulation H19 plays an important role in tumorigenicity and stemness of glioblastoma and thus could be a therapeutic target for treatment of glioblastoma in the future. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26274999 PTCSC3 papillary thyroid carcinoma Regulation PTCSC3 impacts PTC predisposition and carcinogenesis through the S100A4 pathway. chr14 36135710 36176651 - Human N/A NR_049735 26274343 H19 hepatocellular carcinoma Expression The lncRNA H19 is a putative therapeutic target in hepatocellular carcinoma. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26272696 EGFR-AS1 hepatocellular carcinoma Regulation "The inhibition of EGFR-AS1 in HCC cells significantly impeded cell proliferation and invasion in vivo, which might provide a potential possibility for targeted therapy of HCC." chr7 55179750 55188949 - Human N/A NR_047551 26271667 HOTTIP lung cancer Regulation LncRNA HOTTIP contributes to tumor growth in vivo and in vitro and inhibits cell apoptosis in lung cancer. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 26265284 MALAT1 non-small cell lung cancer Expression "MALAT1 expression by regulation of TDP 43 controls cellular growth, migration, and invasion of NSCLCs." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26265046 HOTAIR acute myeloid leukemia Expression HOTAIR is upregulated in acute myeloid leukemia and that indicates a poor prognosis. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26261618 sONE hypertension Regulation L.barbarum L. had anti-hypertensive effect and might lower blood pressure by suppressing the expression of lncRNA sONE in BHR model N/A N/A N/A N/A Mouse N/A N/A 26261587 AP001631.9 gastric cancer Regulation LncRNA-AP001631.9 plays critical roles in gastric cancer progression and can serve as a potential new target for the treatment of gastric cancer. N/A N/A N/A N/A Human N/A N/A 26261500 MALAT1 bladder cancer Expression MALAT1 might serve as a potential prognostic biomarker for various cancers. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26254614 MALAT1 colorectal cancer Expression MALAT1 might serve as a potential prognostic biomarker for various cancers. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26254614 MALAT1 kidney cancer Expression MALAT1 might serve as a potential prognostic biomarker for various cancers. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26254614 MEG3 gastric cancer Regulation Long non-coding RNA MEG3 functions as acompeting endogenous RNA to regulate gastric cancer progression. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26253106 SNHG1 astrocytoma Expression The upregulation of ENST00000545440 and NR_002809 was associated with advanced clinical stages of astrocytoma. chr11 62851988 62855888 - Human LINC00057; NCRNA00057; U22HG; UHG; lncRNA16 NR_003098 26252651 LINC01089 astrocytoma Expression The upregulation of ENST00000545440 and NR_002809 was associated with advanced clinical stages of astrocytoma. chr12 121795267 121803484 - Human LIMT NR_002809 26252651 BC002811 astrocytoma Expression "The low expression of BC002811 or XLOC_010967, or the high expression of NR_002809 was significantly associated with poor patient survival." N/A N/A N/A N/A Human N/A N/A 26252651 XLOC_010967 astrocytoma Expression "The low expression of BC002811 or XLOC_010967, or the high expression of NR_002809 was significantly associated with poor patient survival." N/A N/A N/A N/A Human N/A N/A 26252651 HOTAIR breast cancer Regulation LncRNA HOTAIR displayed molecular profiles indistinguishable from invasive breast cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26249178 BANCR gastric cancer Regulation BANCR promoting gastric cancer cells proliferation via regulation of NF-κB1. chr9 69296681 69307056 - Human LINC00586 NR_047671 26248136 AFAP1-AS1 nasopharyngeal carcinoma Expression AFAP1-AS1 might be a potential novel marker that can predict cancer patient prognosis and as a potential therapeutic target for NPC. chr4 7754090 7778928 + Human AFAP1-AS; AFAP1AS NR_026892 26246469 AFAP1-AS1 lung cancer Regulation "AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis." chr4 7754090 7778928 + Human AFAP1-AS; AFAP1AS NR_026892 26245991 LET nasopharyngeal carcinoma Regulation "Long noncoding RNA-LET, which is repressed by EZH2, inhibits cell proliferation and induces apoptosis of nasopharyngeal carcinoma cell." N/A N/A N/A N/A Human N/A N/A 26243049 NEAT1 glioma Regulation Long noncoding RNA NEAT1 promotes glioma pathogenesis by regulating miR-449b-5p/c-Met axis. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 26242266 MALAT1 cervical cancer Regulation MALAT1-miR-124-RBG2 axis is involved in growth and invasion of HR-HPV-positive cervical cancer cells. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26242259 MALAT1 proliferative vitreoretinopathy Expression MALAT1 is a potential prognostic indicator and a target for the diagnosis and gene therapy for PVR diseases. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26241674 SPRY4-IT1 gastric cancer Expression Low expression of SPRY4-IT1 is involved in progression and metastasis of gastric cancer and may represent a novel biomarker of poor prognosis in patients with gastric cancer. chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 26238992 UCA1 colorectal cancer Regulation UCA1 is associated with tumor proliferation and metastasis and predicts poor prognosis in colorectal cancer. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26238511 CYTOR gastric cancer Regulation "Long non-coding RNA Linc00152 is involved in cell cycle arrest, apoptosis, epithelial to mesenchymal transition, cell migration and invasion in gastric cancer." chr2 87455455 87521518 + Human C2orf59; LINC00152; NCRNA00152 NR_024204 26237576 MEG3 gastric cancer Regulation "MiR-141 could be interacting with MEG3 and targeting E2F3, and these factors may play important anti-tumor effects in GC pathogenesis and provide therapeutic targets in the clinics." chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26233544 CRNDE glioma Regulation CRNDE affects the malignant biological characteristics of human glioma stem cells by negatively regulating miR-186. chr16 54845189 54929189 - Human CRNDE ENST00000613942 26231038 CCAT1 hepatocellular carcinoma Expression "CCAT1, acting as a potential biomarker in predicting the prognosis of HCC, is regulated by c-Myc." chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 26225650 FER1L4 colon cancer Expression It is predictive of poor prognosis in colon cancer and may play a crucial role in cancer prevention and treatment. chr20 35558737 35607562 - Human FER1L4 ENST00000615531 26224446 MEG3 renal cell carcinoma Regulation MEG3 induces the apoptosis of RCC cells possibly by activating the mitochondrial pathway. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26223924 TUNAR breast cancer Regulation Long noncoding RNA linc00617 exhibits oncogenic activity in breast cancer chr14 95876392 95925571 + Human HI-LNC78; LINC00617; TUNA NR_038861 26207516 PRNCR1 gastric cancer Mutation SNPs in the lncRNA PRNCR1 may be a biomarker for the etiology of GC. chr8 127079874 127092595 + Human CARLo-3; PCAT8 NR_109833 26206497 H19 bladder cancer Regulation H19-derived miR-675 contributes to bladder cancer cell proliferation by regulating p53 activation. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26198047 ZMAT1 gastric cancer Mutation ZMAT1 transcript variant 2 is a potential diagnostic factor in patients with gastric cancer. N/A N/A N/A N/A Human N/A N/A 26191264 CCAT1 hepatocellular carcinoma Regulation CCAT1 promotes hepatocellular carcinoma cell proliferation and invasion. chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 26191246 NEAT1 hepatocellular carcinoma Regulation NEAT1 acts as a pivotal player in tumorigenesis and metastasis of hepatocellular carcinoma. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 26191242 MALAT1 breast cancer Regulation MALAT1 is a novel regulator of EMT in breast cancer and may be a potential therapeutic target for breast cancer metastasis chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26191181 HOTAIR gastric cancer Regulation Long non-coding RNA HOTAIR promotes HLA-G expression via inhibiting miR-152 in gastric cancer cells. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26187665 HOTAIR glioma Regulation Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26183397 HULC hepatocellular carcinoma Regulation MiR-203 played tumor suppressive roles by downregulating ADAM9 and HULC and indicated its potential application in cancer treatment. chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 26179263 LINC00313 lung cancer Expression LINC00313 could be a biomarker for lung cancer chr21 43462094 43478223 - Human C21orf84; CH507-42P11.5; NCRNA00313 NR_026863 26178480 TCONS_00068220 gastric cancer Regulation lncRNA TCONS_00068220 may play a role in gastric cancer. N/A N/A N/A N/A Human N/A N/A 26177842 HOTAIR liver cancer Regulation LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26172293 H19 esophageal cancer Regulation H19 has a significant role in the development of EC and may serve as a potential prognostic marker and therapeutic target for EC. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26171017 RP11-119F7.4 gastric cancer Regulation LncRNA RP11-119F7.4 may be involved in carcinogenesis and may prove useful as a biomarker for diagnosis and prognostic significance in patients with gastric cancer. N/A N/A N/A N/A Human N/A N/A 26170986 H19 bladder cancer Expression YAP1 and H19 expression levels were detected and correlated with clinical and pathologic grades. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26163939 GAS5 hepatocellular carcinoma Locus GAS5 may act as a proto-oncogene in HCC chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 26163879 UCA1 bladder cancer N/A It plays an important role in bladder cancer chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26161701 UCA1 non-small cell lung cancer Regulation Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR-mutant non-small cell lung cancer. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26160838 AOC4P hepatocellular carcinoma Regulation Long non-coding RNA AOC4P suppresses hepatocellular carcinoma metastasis by enhancing vimentin degradation and inhibiting epithelial-mesenchymal transition. chr17 42865922 42874369 + Human AOC4P ENST00000566825 26160837 H19 gastric cancer Regulation "H19 and miR-141 could compete with each other and affect their target genes in gastric cancer," chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26160158 EGOT breast cancer Regulation EGOT may play an important role in breast cancer progression and prognosis and may serve as a new potential prognostic target in breast cancer patients. chr3 4749192 4751590 - Human EGO; NCRNA00190 NR_004428 26159853 TARID kidney clear cell sarcoma N/A It plays an important role in CCSK chr6 133502252 133889006 - Human EYA4-AS1 NR_109982 26158413 ZEB2-AS1 bladder cancer Regulation CAFs induces EMT and invasion of human UBC cells through the TGFβ1-ZEB2NAT-ZEB2 axis. chr2 144519614 144520899 + Human ZEB2-AS; ZEB2AS; ZEB2NAT NR_040248 26152796 HOTAIR cervical cancer Regulation "Our study depicts one of the causal mechanisms of cervical carcinogenesis by HPV16 E7, through modulation of HOTAIR expression and function." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26152361 lncRNA-CD244 tuberculosis infection Regulation Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection. N/A N/A N/A N/A Human N/A N/A 26150504 NEAT1 HIV Expression The presence of NEAT1 in plasma is a potential biomarker of HIV-1 infection. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 26139386 MALAT1 HIV N/A MALAT1 may interact with HIV-1 in vivo chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26139386 UCA1 bladder cancer Expression It may be a biomarker for bladder cancer diagnosis. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26138586 MALAT1 lung cancer Expression MALAT1 as a biomarker to screen lung cancer may represent a host response to lung cancer. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 26137228 lncRNA-AK058003 breast cancer Regulation "Unregulated lncRNA-AK058003 in breast cancer cells promotes cancer cell proliferation, invasion and metastasis via the regulation of SNCG expression." N/A N/A N/A N/A Human N/A N/A 26136884 SOX2-OT esophageal squamous cell carcinoma Regulation It plays an important role during development and tumorigenesis chr3 181056680 181742228 + Human NCRNA00043; SOX2OT NR_075089 26136768 SOX2-OT lung squamous cell carcinoma Regulation It plays an important role during development and tumorigenesis chr3 181056680 181742228 + Human NCRNA00043; SOX2OT NR_075089 26136768 SOX2-OT breast cancer Regulation It plays an important role during development and tumorigenesis chr3 181056680 181742228 + Human NCRNA00043; SOX2OT NR_075089 26136768 H19 hepatocellular carcinoma Expression H19 and UCA1 were both demonstrated to be risk factors of HCC disease-free survival in multivariate Cox model chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26136615 UCA1 hepatocellular carcinoma Expression H19 and UCA1 were both demonstrated to be risk factors of HCC disease-free survival in multivariate Cox model chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26136615 HULC hepatocellular carcinoma Regulation HULC had a significant association with vascular invasion chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 26136615 HOTAIR gastric cancer Regulation HOTAIR acts as an EMT regulator and may be a candidate prognostic biomarker and a target for new therapies in GC patients. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26136075 H19 glioma Regulation The lncRNA may play an important role in glioma recurrence chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26131076 CRNDE glioma Regulation The lncRNA may play an important role in glioma recurrence chr16 54845189 54929189 - Human CRNDE ENST00000613942 26131076 HOTAIRM1 glioma Regulation The lncRNA may play an important role in glioma recurrence chr7 27096094 27100258 + Human HOXA-AS1; HOXA1-AS1; NCRNA00179 NR_038367 26131076 AC016745.3 glioma Regulation The lncRNA may play an important role in glioma recurrence chr2 113424495 113425324 + Human AC016745.1 ENST00000422178 26131076 XLOC_001711 glioma Regulation The lncRNA may play an important role in glioma recurrence N/A N/A N/A N/A Human N/A N/A 26131076 RP11-128A17.1 glioma Regulation The lncRNA may play an important role in glioma recurrence chr15 37099339 37100173 + Human AC078909.1 ENST00000559509 26131076 HOTAIR ovarian cancer Regulation "HOTAIR can promote proliferation, migration, and invasion in ovarian SKOV3 cells as a competing endogenous RNA." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26117268 HOTAIR glioblastoma Regulation "The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26111795 HOTAIR cervical cancer Expression "HOTAIR may be a predictor of poor prognosis in four of the main estrogen-dependent tumors, especially in cervical, ovarian, and endometrial cancer patients without preoperative treatment in Asian populations." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26109871 HOTAIR ovarian cancer Expression "HOTAIR may be a predictor of poor prognosis in four of the main estrogen-dependent tumors, especially in cervical, ovarian, and endometrial cancer patients without preoperative treatment in Asian populations." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26109871 HOTAIR endometrial cancer Expression "HOTAIR may be a predictor of poor prognosis in four of the main estrogen-dependent tumors, especially in cervical, ovarian, and endometrial cancer patients without preoperative treatment in Asian populations." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26109871 LK4P2 hepatocellular carcinoma Regulation The lncRNA may participate in regulating HBV related HCC N/A N/A N/A N/A Human N/A N/A 26109807 CASC15 neuroblastoma Regulation "CASC15-S is a mediator of neural growth and differentiation, which impacts neuroblastoma initiation and progression." chr6 21666444 22194400 + Human LINC00340; lnc-SOX4-1 NR_015410 26100672 TCONS_l2_00001418 prostate cancer Expression The lincRNA can be a candidate biomarker for Pca diagnosis and prognosis N/A N/A N/A N/A Human N/A N/A 26100580 TCONS_l2_00008237 prostate cancer Expression The lincRNA can be a candidate biomarker for Pca diagnosis and prognosis N/A N/A N/A N/A Human N/A N/A 26100580 TCONS_l2_00011130 prostate cancer Expression The lincRNA can be a candidate biomarker for Pca diagnosis and prognosis N/A N/A N/A N/A Human N/A N/A 26100580 TCONS_l2_00013175 prostate cancer Expression The lincRNA can be a candidate biomarker for Pca diagnosis and prognosis N/A N/A N/A N/A Human N/A N/A 26100580 TCONS_l2_00022611 prostate cancer Expression The lincRNA can be a candidate biomarker for Pca diagnosis and prognosis N/A N/A N/A N/A Human N/A N/A 26100580 TCONS_l2_00022670 prostate cancer Expression The lincRNA can be a candidate biomarker for Pca diagnosis and prognosis N/A N/A N/A N/A Human N/A N/A 26100580 linc-PXN-1 prostate cancer Expression The lincRNA can be a candidate biomarker for Pca diagnosis and prognosis N/A N/A N/A N/A Human N/A N/A 26100580 PCAT1 hepatocellular carcinoma Expression PCAT-1 up-regulation may serve as a novel biomarker of poor prognosis in HCC patients. chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 26097602 SOX2-OT hepatocellular carcinoma Regulation "LncRNA Sox2ot played crucial roles in promoting HCC cell migration and invasion, and might represent a novel prognostic biomarker for HCC." chr3 181056680 181742228 + Human NCRNA00043; SOX2OT NR_075089 26097588 HA117 Hirschsprung's disease Regulation "LncRNA HA117 may have an anti-differentiation function, and play a pivotal role in the progression of HSCR." N/A N/A N/A N/A Human N/A N/A 26097584 PVT1 ovarian cancer Expression Carboplatin-docetaxel-induced activity against ovarian cancer is dependent on up-regulated lncRNA PVT1. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 26097562 NBAT1 renal clear cell carcinoma Expression Decreased expression of long non-coding RNA NBAT-1 is associated with poor prognosis in patients with clear cell renal cell carcinoma. chr6 22134602 22147193 - Human CASC14; NBAT-1 NR_034143 26097558 H19 gastric cancer Expression "Plasma H19 could serve as a potential biomarker for diagnosis of GC, in particular for early tumor screening." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26096073 MEG3 osteoarthritis Regulation MEG3 may be involved in OA development through the regulation of angiogenesis. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26090403 H19 endometriosis Regulation H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26089099 HOTAIR non-small cell lung cancer Regulation "Under hypoxic conditions, HOTAIR enhanced cancer cell proliferation, migration, and invasion." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26088446 PCA3 prostate cancer Regulation PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3. chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 26080435 XR_250621.1 breast cancer N/A It can be a potential therapeutic target for breast cancer N/A N/A N/A N/A Human N/A N/A 26078338 NONHSAT125629 breast cancer N/A It can be a potential therapeutic target for breast cancer N/A N/A N/A N/A Human N/A N/A 26078338 ZFAS1 hepatocellular carcinoma Regulation Our results establish a function for ZFAS1 in metastatic progression and suggest its candidacy as a new prognostic biomarker and target for clinical management of HCC. chr20 49278178 49289260 + Human C20orf199; HSUP1; HSUP2; NCRNA00275; ZNFX1-AS1 NR_036658 26069248 H19 colorectal cancer Regulation The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 26068968 CCAT1 colorectal cancer Regulation "CCAT1 plays an important role in the genesis, development, invasion and metastasis; it mediates the EMT process of colorectal cancer; and it's expected to be a new marker and treatment target in colorectal diagnosis and treatment." chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 26064266 HIF1A-AS1 thoracoabdominal aorta aneurysm Expression "HIF1a-AS1 was overexpressed in the TAAA and the interaction between HIF1a-AS1 and apoptotic proteins plays a key role in the proliferation and apoptosis of VSMCs in vitro, which may contribute to the pathogenesis of TAAA." chr14 61681041 61695823 - Human 5'aHIF-1A; 5'aHIF1alpha NR_047116 26062299 MEG3 non-small cell lung cancer Regulation Meg3 may have a crucial role in the development of cisplatin resistance in non-small cell lung cancer. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 26059239 HOTTIP tongue squamous cell carcinoma Regulation Long non-coding RNA HOTTIP is correlated with progression and prognosis in tongue squamous cell carcinoma. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 26058875 RGMB-AS1 non-small cell lung cancer Expression "LncRNA RGMB-AS1 was upregulated and RGMB was downregulated in NSCLC patients. Both were related to differentiation status, lymph node metastases and TNM stage." chr5 98769618 98773084 - Human N/A NR_033932 26055877 PANDAR hepatocellular carcinoma Regulation Long non-coding RNA PANDAR correlates with poor prognosis and promotes tumorigenesis in hepatocellular carcinoma. chr6 36673621 36675126 - Human PANDA NR_109836 26054684 BANCR gastric cancer Expression Increased expression of LncRNA BANCR is associated with clinical progression and poor prognosis in gastric cancer. chr9 69296681 69307056 - Human LINC00586 NR_047671 26054683 HOXA11-AS uterine cervix carcinoma Regulation "HOXA11-AS might participate in cervix carcinogenesis by regulating HOXA11, which is involved in regulating biological processes of cervix cancer." chr7 27185408 27189293 + Human HOXA-AS51; HOXA11AS; HOXA11S; NCRNA00076; HOXA11-AS NR_002795 26054679 UCA1 acute myeloid leukemia Regulation UCA1 sustains proliferation of AML cells by repressing the expression of the cell cycle regulator p27kip1. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 26053097 DLX6-AS1 lung adenocarcinoma Expression High DLX6-AS1 expression levels were significantly associated with both histological differentiation and TNM stage. chr7 96968515 97014065 - Human DLX6-AS; DLX6AS; Evf-2; NCRNA00212 NR_015448 26052251 CLMAT3 colorectal cancer Expression LncRNA-CLMAT3 over-expression was significantly associated with CLM and was an independent predictor of poor survival for patients with CRC. N/A N/A N/A N/A Human N/A N/A 26050227 CDKN2B-AS1 hepatocellular carcinoma Expression LncRNA ANRIL may serve as an efficient clinical biomarker and a therapeutic target for HCC patients. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 26045820 HULC osteosarcoma Regulation "HULC is a novel molecule involved in osteosarcoma progression, which may provide a new marker of poor prognosis and a potential therapeutic target for osteosarcoma intervention." chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 26045809 AK094457 hypertension Regulation Notoginsenoside R1 reduces blood pressure in spontaneously hypertensive rats through a long non-coding RNA AK094457. N/A N/A N/A N/A Mouse N/A N/A 26045775 AF339813 pancreatic cancer Regulation NUF2 is consistently overexpressed in human PC and NUF2 is closely linked with human PC progression through the meditator LncRNA AF339813 N/A N/A N/A N/A Human N/A N/A 26045769 PVT1 cardiac hypertrophy Expression PVT1 was essential for the maintenance of cell size of cardiomyocytes and might play a role in the regulation of cardiac hypertrophy. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 26045764 XLOC_010235 gastric cancer Expression "It can be identified as novel, poor prognostic biomarkers in GC." N/A N/A N/A N/A Human N/A N/A 26045391 RP11-789C1.1 gastric cancer Expression "It can be identified as novel, poor prognostic biomarkers in GC." chr4 170273919 170283079 + Human LINC01612 ENST00000504509 26045391 APTR liver fibrosis Regulation Long non-coding RNA APTR promotes the activation of hepatic stellate cells and the progression of liver fibrosis. chr7 77657660 77697345 - Human RSBN1L-AS1 NR_038361 26043697 HOTTIP Hirschsprung's disease Regulation "Aberrant reduction of HOTTIP and HOXA13, which have a bidirectional regulatory loop, may play an important role in the pathogenesis of HSCR." chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 26043692 HOTAIR oral squamous cell carcinoma Expression "HOTAIR was highly expressed in OSCC tissues and facilitated the growth of OSCC cells, thus probably being an eligible molecular marker for OSCC diagnosis and prognosis determination." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26036760 HOTAIR breast cancer Expression Circulating DNA of HOTAIR in serum is a novel biomarker for breast cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26033707 HOTAIR hepatocellular carcinoma Regulation "Hotair silence activates P16(Ink4a) and P14(ARF) signaling by enhancing miR-218 expression and suppressing Bmi-1 expression, resulting in the suppression of tumorigenesis in HCC." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 26024833 CASC15 melanoma Regulation CASC15 levels correlated with known gene signatures corresponding to melanoma proliferative and invasive phenotypes. chr6 21666444 22194400 + Human LINC00340; lnc-SOX4-1 NR_015410 26016895 BCAR4 breast cancer Regulation LncRNA BCAR4 wires up signaling transduction in breast cancer chr16 11819830 11828832 - Human N/A NR_024050 26016563 MIAT schizophrenia Locus LncRNA MIAT was a novel susceptibility gene for paranoid schizophrenia in the Chinese Han population chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 26004688 MEG3 thyroid cancer Regulation Long non-coding RNA MEG3 suppresses migration and invasion of thyroid carcinoma by targeting of Rac1. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 25997963 LINC00993 breast cancer Regulation It may be involved in the development and/or progression of TNBC. chr10 37309186 37347029 + Human N/A NR_104061 25996380 CCAL colorectal cancer Regulation CCAL is a crucial oncogenic regulator involved in CRC tumorigenesis and progression. N/A N/A N/A N/A Human N/A N/A 25994219 HOTAIR urothelial cancer Expression "HOTAIR overexpression may affect differentiation state and aggressiveness of UC cells, but in a cell-type dependent manner." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25994132 LINC0949 systemic lupus erythematosus Expression "Linc0949 could be a potential biomarker for diagnosis, disease activity and therapeutic response in SLE." N/A N/A N/A N/A Human N/A N/A 25994030 MEG3 lung adenocarcinoma Expression MEG3 may represent a new marker of poor response to cisplatin and could be a potential therapeutic target for LAD chemotherapy. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 25992654 ATB gastric cancer Regulation "LncRNA-ATB plays an important role in EMT to promote invasion and metastasis through the TGF-β/miR-200s/ZEB axis, resulting in a poor prognosis in GC." N/A N/A N/A N/A Human N/A N/A 25986864 HOTAIR acute myeloid leukemia Regulation HOTAIR plays an important oncogenic role in AML and might serve as a marker for AML prognosis and a potential target for therapeutic intervention. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25979172 SPRY4-IT1 bladder cancer Regulation "lncRNA SPRY4-IT1 is a novel molecule involved in bladder cancer progression, which provide a potential prognostic biomarker and therapeutic target." chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 25973088 AI364715 gastric cancer Expression AI364715 may be a potential biomarker for the diagnosis of gastric cancer N/A N/A N/A N/A Human N/A N/A 25971582 NEAT1 chronic lymphocytic leukemia Regulation LncRNAs NEAT1 and lincRNA-p21 are identified as novel elements of the p53-dependent DNA damage response machinery in CLL and lymphoma. chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 25971364 HOTAIR esophageal squamous cell carcinoma Expression HOTAIR expression may serve as a candidate positive marker to predict the prognosis of patients with carcinoma of digestive system. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25968902 HOTAIR gastric cancer Expression HOTAIR expression may serve as a candidate positive marker to predict the prognosis of patients with carcinoma of digestive system. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25968902 UCA1 ovarian cancer Regulation "UCA1 can improve the cell migration, invasion and induce cisplatin resistance." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 25967360 CDKN2B-AS1 hepatocellular carcinoma Regulation "LncRNA ANRIL, as a growth regulator, may serve as a new biomarker and target for therapy in HCC." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 25966845 CDKN2B-AS1 lung cancer Regulation ANRIL is an lncRNA responsible in anti-tumorigenesis caused by PLD inhibition and combined incorporation of ANRIL into PLD inhibition-induce chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 25964559 DANCR hepatocellular carcinoma Regulation Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1 chr4 52712454 52714138 + Human AGU2; ANCR; KIAA0114; SNHG13; lncRNA-ANCR NR_024031 25964079 BANCR lung cancer Regulation Knockdown of BANCR expression promoted cell viability surviving from radiation. chr9 69296681 69307056 - Human LINC00586 NR_047671 25960219 GAS5 gastric cancer Regulation "LncRNA GAS5 down-regulation reduced the YBX1 protein level, which decreased YBX1-transactivated p21 expression and abolished G1 phase cell cycle arrest in stomach cancer." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 25959498 PVT1 gastric cancer Expression "Overexpression of LncRNA PVT1 in gastric carcinoma promotes the development of MDR, suggesting an efficacious target for reversing MDR in gastric cancer therapy." chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 25956062 HULC liver cirrhosis Regulation LncRNA HULC affects the differentiation of Treg in HBV-related liver cirrhosis. chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 25952928 H19 gastric cancer Mutation LncRNA H19 SNPs may contribute to susceptibility to GC. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 25944697 PCAT1 bladder cancer Regulation PCAT-1 plays oncogenic roles and can be used as a therapeutic target for treating human bladder cancer. chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 25934337 RP11-445H22.4 breast cancer Expression LncRNA RP11-445H22.4 may be a new potential biomarker of breast cancer. chr20 44694892 44746021 - Human KCNK15-AS1 ENST00000427303 25929808 CCDC26 acute myeloid leukemia Regulation CCDC26 controls growth of myeloid leukemia cells through regulation of KIT expression. chr8 129351694 129680239 - Human RAM NR_130917 25928165 BANCR colorectal cancer Regulation "Down-regulation of BANCR contributes to the proliferation of colorectal cancer cells, at least in part, through the regulation of p21 protein." chr9 69296681 69307056 - Human LINC00586 NR_047671 25928067 HOTAIR breast cancer Regulation Estrogen promoted HOTAIR through its receptor GPER and estrogen-induced breast cancer cell migration was reversed by deleting HOTAIR in TN breast cancer cells MDA-MB-231and BT549. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25928008 AFAP1-AS1 pancreatic ductal adenocarcinoma Expression AFAP1-AS1 is a potential novel prognostic marker to predict the clinical outcome of PDAC patients after surgery and may be a rational target for therapy. chr4 7754090 7778928 + Human AFAP1-AS; AFAP1AS NR_026892 25925763 GAS5 lung adenocarcinoma Expression "GAS5 LncRNA may represent a potential biomarker for the diagnosis of lung adenocarcinoma and that GAS5 might play a novel role in the development of the resistance to gefitinib, which could be reversed by overexpressing GAS5." chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 25925741 CCEPR cervical cancer Regulation CCHE1 plays a pivotal role in cervical cancer cell proliferation via increasing PCNA expression and serves as a potential prognostic biomarker and therapeutic target in human cervical cancer. chr10 59173963 59176464 - Human CCHE1; lncRNA-CCHE1 NR_131782 25921283 CCAT2 esophageal squamous cell carcinoma Expression CCAT2 may be a prognostic biomarker and therapeutic target for ESCC. chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 25919911 HOTTIP pancreatic cancer Regulation "The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration." chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 25912306 HOTAIR pancreatic cancer Regulation LncRNA HOTAIR regulates strikingly different sets of genes in Panc1 cells and in pancreatic tumors. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25912306 LINC00261 pancreatic cancer N/A It plays an important role in pancreatic cancer chr20 22560553 22578642 - Human ALIEN; C20orf56; DEANR1; HCCDR1; NCRNA00261; onco-lncRNA-17 NR_001558 25910082 CYTOR pancreatic cancer N/A It plays an important role in pancreatic cancer chr2 87455455 87521518 + Human C2orf59; LINC00152; NCRNA00152 NR_024204 25910082 HNF1A-AS1 pancreatic cancer N/A It plays an important role in pancreatic cancer chr12 120969838 120972292 - Human C12orf27; NCRNA00262 NR_024345 25910082 AFAP1-AS1 pancreatic cancer N/A It plays an important role in pancreatic cancer chr4 7754090 7778928 + Human AFAP1-AS; AFAP1AS NR_026892 25910082 LINC01133 lung squamous cell carcinoma Expression A novel long noncoding RNA LINC01133 is upregulated in lung squamous cell cancer and predicts survival. chr1 159961224 159979086 + Human N/A NR_038849 25908174 FRLnc1 gastric cancer Regulation "FRLnc1 knockdown by RNA interference suppressed cell migration in MGC803 and AGS cells, whereas FRLnc1 overexpression promoted cell migration in BGC823 and SGC7901 cells." N/A N/A N/A N/A Human N/A N/A 25907137 UCA1 gastric cancer Expression UCA1 might serve as a promising biomarker for early detection and prognosis prediction of gastric cancer. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 25903045 HOTAIR oral squamous cell carcinoma Regulation Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25901533 ZXF2 lung adenocarcinoma Expression The high expression of ZXF was closely related to tumor progression through c-Myc related pathway N/A N/A N/A N/A Human N/A N/A 25896422 HOTAIR prostate cancer Regulation Infiltrating mast cells enhance prostate cancer invasion via altering LncRNA-HOTAIR/PRC2-androgen receptor (AR)-MMP9 signals and increased stem/progenitor cell population. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25895025 LINC01296 colorectal cancer Expression Long non-coding RNA LINC01296 is a potential prognostic biomarker in patients with colorectal cancer. chr14 19062377 19107497 + Human N/A NR_122112 25894381 BANCR retinoblastoma Regulation LncRNA BANCR plays a significant role in retinoblastoma aggressiveness and prognosis and may act as a promising target for therapeutic strategy and prognostic prediction. chr9 69296681 69307056 - Human LINC00586 NR_047671 25894373 linc-ITGB1 gallbladder cancer Regulation Long non-coding RNA Linc-ITGB1 knockdown inhibits cell migration and invasion in GBC-SD/M and GBC-SD gallbladder cancer cell lines. N/A N/A N/A N/A Human N/A N/A 25893892 PVT1 gastric cancer Expression Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 25890171 CDKN2B-AS1 lung cancer Regulation Increased expression of the long non-coding RNA ANRIL promotes lung cancer cell metastasis and correlates with poor prognosis. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 25889788 HOTTIP pancreatic cancer Regulation "HOTTIP promotes cell proliferation, invasion, and chemoresistance by modulating HOXA13" chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 25889214 MIR4435-2HG lung cancer Locus A novel long noncoding RNA AK001796 acts as an oncogene and is involved in cell growth inhibition by resveratrol in lung cancer. chr2 111195866 111495161 - Human AGD2; AK001796; LINC00978; MIR4435-1HG NR_024373 25888808 CASC9 esophageal squamous cell carcinoma Locus ESCCAL-1 is a novel putative onco-lncRNA in esophageal cancer development. chr8 75223117 75278889 - Human ESCCAL-1; ESSCAL1; LINC00981 NR_103848 25885227 CCAT1 hepatocellular carcinoma Regulation "CCAT1 plays a pivotal role in HCC progression via functioning as let-7 sponge, and implicate the potential application of CCAT1 for the prognosis and treatment of HCC." chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 25884472 HOTAIR breast cancer Regulation Combined inhibition of EGFR and c-ABL suppresses the growth of triple-negative breast cancer growth through inhibition of HOTAIR. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25883211 HULC esophageal cancer Mutation A long noncoding RNA HULC rs7763881 A/C polymorphism is associated with decreased risk of esophageal cancer. chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 25874495 ATB breast cancer Regulation LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer. N/A N/A N/A N/A Human N/A N/A 25871474 BCYRN1 non-small cell lung cancer Regulation "BCYRN1, a c-MYC-activated long non-coding RNA, regulates cell metastasis of non-small-cell lung cancer." chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 25866480 UCA1 ovarian cancer Regulation "UCA1 can improve the cell migration, invasion and induce cisplatin resistance." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 25866223 H19 renal cell carcinoma Expression LncRNA H19 might be considered as a potential prognostic indicator and a target for gene therapy of ccRCC. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 25866221 LINC00472 breast cancer Expression This long non-coding RNA in breast tumors may have prognostic and predictive value in the clinical management of breast cancer. chr6 71407864 71420745 - Human C6orf155 NR_121612 25865225 HNF1A-AS1 lung adenocarcinoma Regulation The long non-coding RNA HNF1A-AS1 regulates proliferation and metastasis in lung adenocarcinoma. chr12 120969838 120972292 - Human C12orf27; NCRNA00262 NR_024345 25863539 APF myocardial infarction Regulation APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p. N/A N/A N/A N/A Human N/A N/A 25858075 HOTAIR liver cancer N/A PLK1 and HOTAIR Accelerate Proteasomal Degradation of SUZ12 and ZNF198 during Hepatitis B Virus-Induced Liver Carcinogenesis. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25855382 NEAT1 non-small cell lung cancer Regulation "NEAT1 might be associated with oncogenesis and progression in NSCLC, and suggests application in molecular targeted therapy." chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 25854373 Lnc_bc060912 lung cancer Regulation "Lnc_bc060912, via PARP1 and NPM1, affects cell apoptosis and may play important roles in tumorigenesis and cancer progression." N/A N/A N/A N/A Human N/A N/A 25848691 H19 breast cancer Expression "H19 lncRNA may serve as a biomarker for breast cancer diagnosis and progression, and as a valuable target for breast cancer therapy." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 25846769 CDKN2B-AS1 ovarian cancer Regulation LncRNA ANRIL plays an important role in SOC invasion/metastasis and could represent a novel biomarker for predicting poor survival as well a promising therapeutic target. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 25845387 lncTCF7 liver cancer Regulation LncTCF7-mediated Wnt signaling primes liver CSC self-renewal and tumor propagation. N/A N/A N/A N/A Human N/A N/A 25842979 SPRY4-IT1 gastric cancer Regulation SPRY4-IT1 plays a critical role in GC tumorigenesis and may represent a novel prognostic marker and potential therapeutic target in patients with GC. chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 25835973 HOTAIR ovarian cancer Regulation "HOTAIR may be used in the development of novel treatments for ovarian cancer, particularly those that are resistant to conventional therapies." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25824616 HOTAIR glioblastoma N/A HOTAIR was required for GBM formation in vivo chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25823657 LOC728228 lung cancer Regulation "LOC728228 knockdown inhibited cell proliferation, caused G0/G1-phase cell-cycle arrest, reduced cellular migration, suppressed colony formation in vitro, and inhibited tumor growth in a nude mouse xenograft model." N/A N/A N/A N/A Human N/A N/A 25820656 SNHG1 non-small cell lung cancer Regulation Noncoding RNA small nucleolar RNA host gene 1 promote cell proliferation in nonsmall cell lung cancer. chr11 62851988 62855888 - Human LINC00057; NCRNA00057; U22HG; UHG; lncRNA16 NR_003098 25818744 CRNDE glioma Regulation "CRNDE, a long-noncoding RNA, promotes glioma cell growth and invasion through mTOR signaling." chr16 54845189 54929189 - Human CRNDE ENST00000613942 25813405 MALAT1 pancreatic cancer Regulation MALAT-1 could promote tumorigenicity of pancreatic cancer cells in vivo chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25811929 HOTAIR pre-eclampsia Regulation "OTAIR is probably involved in the onset of preeclampsia by regulating proliferation, invasion and apoptosis of trophoblast cells" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25807808 HOTAIR ovarian cancer Regulation The long non-coding RNA HOTAIR promotes the proliferation of serous ovarian cancer cells through the regulation of cell cycle arrest and apoptosis. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25796453 HOTAIR ovarian cancer Regulation Downregulated lincRNA HOTAIR expression in ovarian cancer stem cells decreases its tumorgeniesis and metastasis by inhibiting epithelial-mesenchymal transition chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25792974 MALAT1 hyperglycaemia Regulation Long non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25787249 MALAT1 lung cancer Expression "Upregulation of MALAT1 was mediated by the transcription factor Sp1 in A549 lung cancer cells, and Sp1 could be therapeutic target for cancer." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25773124 MALAT1 glioblastoma Regulation "Knockdown of MALAT1 reduced migration in glioblastoma cells, without effect on proliferation." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25772239 H19 coronary artery disease Mutation Common polymorphisms of H19 are associated with the risk and severity of CAD in a Chinese population. chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 25772106 UCA1 gastric cancer Regulation It plays a potential role in the process of gastric cancer progression. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 25769450 lincRNA-BBOX1-2 gastric cancer Regulation It plays a potential role in the process of gastric cancer progression. N/A N/A N/A N/A Human N/A N/A 25769450 CR594506 gastric cancer Regulation It plays a potential role in the process of gastric cancer progression. N/A N/A N/A N/A Human N/A N/A 25769450 BC015134 gastric cancer Regulation It plays a potential role in the process of gastric cancer progression. N/A N/A N/A N/A Human N/A N/A 25769450 TUSC7 gastric cancer Regulation TUSC7 is a p53-regulated tumour suppressor that acts in part by repressing miR-23b and that TUSC7 may be a key regulatory hub in GC. chr3 116709788 116717040 + Human LINC00902; LSAMP-AS1; LSAMP-AS3; LSAMPAS3; NCRNA00295 NR_015391 25765901 AK022798 gastric cancer Regulation Notch 1 promotes cisplatin-resistant gastric cancer formation by upregulating lncRNA AK022798 expression. N/A N/A N/A N/A Human N/A N/A 25763542 HIF1A-AS1 cardiovascular disease Regulation "LncRNA HIF1A-AS1 may play an important role in the pathogenesis of CVD, and provide a novel molecular mechanism of clopidogrel for treatment of CVD." chr14 61681041 61695823 - Human 5'aHIF-1A; 5'aHIF1alpha NR_047116 25761653 UCA1 hepatocellular carcinoma Regulation Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 25760077 NKILA breast cancer Expression Low NKILA expression is associated with breast cancer metastasis and poor patient prognosis. chr20 57710183 57712780 + Human N/A NR_131157 25759022 H19 ovarian cancer Regulation "LncRNAs H19, LSINCT5, and XIST have a close relationship to the development of ovarian cancer occurrence, growth, invasion, and metastasis, and they can promote ovarian cancer cell proliferation." chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 25756403 LSINCT5 ovarian cancer Regulation "LncRNAs H19, LSINCT5, and XIST have a close relationship to the development of ovarian cancer occurrence, growth, invasion, and metastasis, and they can promote ovarian cancer cell proliferation." chr5 2712591 2715237 - Human N/A NR_145480 25756403 XIST ovarian cancer Regulation "LncRNAs H19, LSINCT5, and XIST have a close relationship to the development of ovarian cancer occurrence, growth, invasion, and metastasis, and they can promote ovarian cancer cell proliferation." chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 25756403 LET cervical cancer Regulation Low expression of long non-coding RNA LET inhibits carcinogenesis of cervical cancer. N/A N/A N/A N/A Human N/A N/A 25755778 CCAT2 gastric cancer Expression Long non-coding RNA CCAT2 is up-regulated in gastric cancer and associated with poor prognosis. chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 25755774 BLACAT1 gastric cancer Regulation Long noncoding RNA linc-UBC1 is negative prognostic factor and exhibits tumor pro-oncogenic activity in gastric cancer. chr1 205434886 205456086 - Human LINC00912; linc-UBC1; onco-lncRNA-30 NR_103783 25755750 MEG3 multiple myeloma Expression LncRNA MEG3 expression as a potential biomarker for identifying patients with MM and as a potential therapeutic target in MM. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 25753650 lncRNA-ATB colorectal cancer Regulation "A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer." N/A N/A N/A N/A Human N/A N/A 25750289 BOK-AS1 esophageal squamous cell carcinoma Regulation "LncRNA BOKAS was up-regulated following radiation and promoted WISP1 expression and resultant radioresistance, and WISP1 is a potential target to overcome radioresistance in ESCC" chr2 241544384 241559143 - Human BOK-AS; BOKAS; NAToB; NCRNA00151 NR_033346 25749038 PCGEM1 prostate cancer Expression The clinical expression profile of PCGEM1 implicates it in the early stages of PCa warranting further research in this direction. chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 25744782 SPRY4-IT1 breast cancer Regulation The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression. chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 25742952 Arid2-IR renal inflammatory disease Regulation Arid2-IR is a novel lncRNA that functions to promote NF-κB-dependent renal inflammation. N/A N/A N/A N/A Human N/A N/A 25743111 BANCR melanoma Regulation Long non-coding RNA BANCR promotes proliferation in malignant melanoma by regulating MAPK pathway activation. chr9 69296681 69307056 - Human LINC00586 NR_047671 25742304 LNC00964-3 colorectal cancer Regulation "PiR-015551 may be generated from LNC00964-3, which may be involved in the development of CRC." N/A N/A N/A N/A Human N/A N/A 25740697 HOTAIR breast cancer Expression HOTAIR appears to be a marker for lymphatic metastases rather than hematogenous metastases in ER-negative patients. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25739705 HOTAIR breast cancer Regulation HOTAIR is associated with early metastasis and expression of the known predictor of metastatic progression chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25734557 PCAT1 esophageal squamous cell carcinoma Expression High expression of PCAT-1 might reflect poor prognosis of ESCC and indicate a potential diagnostic target in ESCC patients. chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 25731728 HOTAIR osteosarcoma Regulation Overexpression of Long Non-Coding RNA HOTAIR Promotes Tumor Growth and Metastasis in Human Osteosarcoma. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25728753 TINCR gastric cancer Regulation TINCR contributes to the oncogenic potential of GC and may constitute a potential therapeutic target in this disease. chr19 5558167 5568034 - Human LINC00036; NCRNA00036; PLAC2; onco-lncRNA-16 NR_027064 25728677 NRON HIV Regulation The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins. chr9 126407775 126410504 - Human NCRNA00194 NR_045006 25728138 MALAT2 gastric cancer Expression MALAT2-activated long noncoding RNA indicates a biomarker of poor prognosis in gastric cancer. N/A N/A N/A N/A Human N/A N/A 25721209 PANDAR non-small cell lung cancer Expression Low expression of long noncoding RNA PANDAR predicts a poor prognosis of non-small cell lung cancer and affects cell apoptosis by regulating Bcl-2. chr6 36673621 36675126 - Human PANDA NR_109836 25719249 RP11-160H22.5 hepatocellular carcinoma Expression "RP11-160H22.5, XLOC_014172 and LOC149086 might be the potential biomarker for the tumorigenesis prediction" chr1 174115300 174160004 - Human AL121983.2 ENST00000430592 25714016 XLOC_014172 hepatocellular carcinoma Expression "RP11-160H22.5, XLOC_014172 and LOC149086 might be the potential biomarker for the tumorigenesis prediction" N/A N/A N/A N/A Human N/A N/A 25714016 LOC149086 hepatocellular carcinoma Expression "RP11-160H22.5, XLOC_014172 and LOC149086 might be the potential biomarker for the tumorigenesis prediction" N/A N/A N/A N/A Human N/A N/A 25714016 DRAIC bladder cancer Expression "DRAIC expression predicts good prognosis in a wide range of malignancies, including bladder cancer, low-grade gliomas, lung adenocarcinoma, stomach adenocarcinoma, renal clear cell carcinoma, hepatocellular carcinoma, skin melanoma" chr15 69561720 69571440 + Human N/A NR_026979 25700553 DRAIC glioma Expression "DRAIC expression predicts good prognosis in a wide range of malignancies, including bladder cancer, low-grade gliomas, lung adenocarcinoma, stomach adenocarcinoma, renal clear cell carcinoma, hepatocellular carcinoma, skin melanoma" chr15 69561720 69571440 + Human N/A NR_026979 25700553 DRAIC lung adenocarcinoma Expression "DRAIC expression predicts good prognosis in a wide range of malignancies, including bladder cancer, low-grade gliomas, lung adenocarcinoma, stomach adenocarcinoma, renal clear cell carcinoma, hepatocellular carcinoma, skin melanoma" chr15 69561720 69571440 + Human N/A NR_026979 25700553 DRAIC stomach adenocarcinoma Expression "DRAIC expression predicts good prognosis in a wide range of malignancies, including bladder cancer, low-grade gliomas, lung adenocarcinoma, stomach adenocarcinoma, renal clear cell carcinoma, hepatocellular carcinoma, skin melanoma" chr15 69561720 69571440 + Human N/A NR_026979 25700553 DRAIC renal clear cell carcinoma Expression "DRAIC expression predicts good prognosis in a wide range of malignancies, including bladder cancer, low-grade gliomas, lung adenocarcinoma, stomach adenocarcinoma, renal clear cell carcinoma, hepatocellular carcinoma, skin melanoma" chr15 69561720 69571440 + Human N/A NR_026979 25700553 DRAIC hepatocellular carcinoma Expression "DRAIC expression predicts good prognosis in a wide range of malignancies, including bladder cancer, low-grade gliomas, lung adenocarcinoma, stomach adenocarcinoma, renal clear cell carcinoma, hepatocellular carcinoma, skin melanoma" chr15 69561720 69571440 + Human N/A NR_026979 25700553 DRAIC skin melanoma Expression "DRAIC expression predicts good prognosis in a wide range of malignancies, including bladder cancer, low-grade gliomas, lung adenocarcinoma, stomach adenocarcinoma, renal clear cell carcinoma, hepatocellular carcinoma, skin melanoma" chr15 69561720 69571440 + Human N/A NR_026979 25700553 PCAT29 bladder cancer Regulation "A second tumor-suppressive lncRNA PCAT29, located 20 kb downstream of DRAIC, is regulated identically by AR and FOXA1 and also suppresses cellular migration and metastasis." chr15 69592200 69695750 + Human N/A NR_126437 25700553 PCAT29 glioma Regulation "A second tumor-suppressive lncRNA PCAT29, located 20 kb downstream of DRAIC, is regulated identically by AR and FOXA1 and also suppresses cellular migration and metastasis." chr15 69592200 69695750 + Human N/A NR_126437 25700553 PCAT29 lung adenocarcinoma Regulation "A second tumor-suppressive lncRNA PCAT29, located 20 kb downstream of DRAIC, is regulated identically by AR and FOXA1 and also suppresses cellular migration and metastasis." chr15 69592200 69695750 + Human N/A NR_126437 25700553 PCAT29 stomach adenocarcinoma Regulation "A second tumor-suppressive lncRNA PCAT29, located 20 kb downstream of DRAIC, is regulated identically by AR and FOXA1 and also suppresses cellular migration and metastasis." chr15 69592200 69695750 + Human N/A NR_126437 25700553 PCAT29 renal clear cell carcinoma Regulation "A second tumor-suppressive lncRNA PCAT29, located 20 kb downstream of DRAIC, is regulated identically by AR and FOXA1 and also suppresses cellular migration and metastasis." chr15 69592200 69695750 + Human N/A NR_126437 25700553 PCAT29 hepatocellular carcinoma Regulation "A second tumor-suppressive lncRNA PCAT29, located 20 kb downstream of DRAIC, is regulated identically by AR and FOXA1 and also suppresses cellular migration and metastasis." chr15 69592200 69695750 + Human N/A NR_126437 25700553 PCAT29 skin melanoma Regulation "A second tumor-suppressive lncRNA PCAT29, located 20 kb downstream of DRAIC, is regulated identically by AR and FOXA1 and also suppresses cellular migration and metastasis." chr15 69592200 69695750 + Human N/A NR_126437 25700553 SNHG12 endometrial cancer Regulation "Expression inhibition of lncRNA ASLNC04080 in HEC-1-B cells caused repression of cell proliferation, increased cell apoptosis, and G1 phase arrest." chr1 28578538 28581854 - Human ASLNC04080; C1orf79; LINC00100; NCRNA00100; PNAS-123 NR_024127 25695231 UCA1 gastric cancer Expression "Circulating CUDR, LSINCT-5 and PTENP1 long noncoding RNAs in sera distinguish patients with gastric cancer from healthy controls." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 25694351 LSINCT5 gastric cancer Expression "Circulating CUDR, LSINCT-5 and PTENP1 long noncoding RNAs in sera distinguish patients with gastric cancer from healthy controls." chr5 2712591 2715237 - Human N/A NR_145480 25694351 PTENP1 gastric cancer Expression "Circulating CUDR, LSINCT-5 and PTENP1 long noncoding RNAs in sera distinguish patients with gastric cancer from healthy controls." chr9 33673504 33677499 - Human PTENP1 ENST00000532280 25694351 HIF1A-AS2 gastric cancer Expression IF1A-AS2 is overexpressed in GC and may play a pivotal role in tumor cell proliferation. chr14 61747039 61749089 - Human 3'aHIF-1A; aHIF NR_045406 25686741 CCAT2 esophageal squamous cell carcinoma Expression "CCAT2 showed higher diagnostic performance than conventional serum biomarkers, like AFP, CA153, and NSE." chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 25677908 LET gastric cancer Expression Down-regulation of long non-coding RNA LET is associated with poor prognosis in gastric cancer. N/A N/A N/A N/A Human N/A N/A 25674261 HMlincRNA717 non-small cell lung cancer Expression "HMlincRNA717 expression was an independent prognostic factor for patients with NSCLC, which might be a potential prognostic biomarker and therapeutic target for NSCLC." N/A N/A N/A N/A Human N/A N/A 25674259 CCAT1 gastric cancer Regulation CARLo-5 might serve as a pro-oncogenic lncRNA that promotes proliferation of gastric cancer and activates the ERK/MAPK pathway. chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 25674211 PVT1 pancreatic cancer Expression "The increased expression of lncRNA PVT1 in PDAC was correlated with tumor progression, and PVT1 might be a potential molecular biomarker for predicting the prognosis of patients with PDAC." chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 25668599 RP4-583P15.10 breast cancer Regulation It may regulated breast cancer through influence immune system. chr20 63744689 63745958 + Human AL121845.1 ENST00000447343 25661361 BANCR lung cancer Regulation Long non-coding RNA BANCR promotes proliferation and migration of lung carcinoma via MAPK pathways. chr9 69296681 69307056 - Human LINC00586 NR_047671 25661343 DANCR postmenopausal osteoporosis Regulation DANCR is involved in the pathology of osteoporosis and may be as a biomarker for postmenopausal osteoporosis. chr4 52712454 52714138 + Human AGU2; ANCR; KIAA0114; SNHG13; lncRNA-ANCR NR_024031 25660720 LINC-ROR glioma Regulation "The reprogramming-related lincRNA-ROR may serve as a novel tumor suppressor gene in glioma, which can inhibit the proliferation of cancer cell and self renewal of GSCs, partly by inhibiting the KLF4 expression." chr18 57054571 57072119 - Human ROR; lincRNA-RoR NR_048536 25651893 GAS5 prostate cancer Regulation This lncRNA promotes the apoptosis of prostate cancer cells and its levels decline as prostate cancer cells acquire castrate-resistance chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 25650269 CDKN2B-AS1 esophageal cancer Regulation The chemotherapeutic drug β-elemene suppressed the proliferation of esophageal carcinoma ECA-109 cells by regulating the inhibition of hTERT expression by lncRNA CDKN2B-AS1. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 25646744 MEG3 hepatocellular carcinoma Regulation MEG3 acts as a potential biomarker in predicting the prognosis of HCC chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 25641194 HOTAIR gastric cancer Regulation A functional lncRNA HOTAIR genetic variant contributes to gastric cancer susceptibility. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25640751 MEG3 colorectal cancer Expression Decreased expression of long noncoding RNA MEG3 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 25636452 H19 gastric cancer Regulation It plays an important role in gastric carcinogenesis chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 25636450 CDKN2B-AS1 gastric cancer Regulation It plays an important role in gastric carcinogenesis chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 25636450 PVT1 hepatocellular carcinoma Regulation Long non-coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients. chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 25624916 HULC liver cancer Regulation HULC contributes to the perturbations in circadian rhythm of hepatoma cells. chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 25622901 Abhd11os Huntington's disease Regulation The loss lncRNA Abhd11os likely contribute to striatal vulnerability in HD N/A N/A N/A N/A Human N/A N/A 25619660 PTENP1 hepatocellular carcinoma Regulation "Co-transduction of HCC cells with the SB-BV vector expressing PTENP1 elevated the levels of PTENP1 and PTEN, which suppressed the oncogenic PI3K/AKT pathway, inhibited cell proliferation, migration/invasion as well as induced autophagy and apoptosis" chr9 33673504 33677499 - Human PTENP1 ENST00000532280 25617127 HOTAIR breast cancer Regulation "Calycosin is more effective in inhibiting breast cancer growth in comparison with genistein, through its regulation of Akt signaling pathways and HOTAIR expression." chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25613518 MALAT1 esophageal squamous cell carcinoma Regulation Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25613496 MALAT1 glioma Regulation LncRNA MALAT1 plays an important role on glioma progression and prognosis and may serve as a convictive prognostic biomarker for glioma patients. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25613066 HOTAIR gastric cancer Regulation HOTAIR Long Noncoding RNA Promotes Gastric Cancer Metastasis through Suppression of Poly r(C)-Binding Protein (PCBP) 1. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25612617 SRA polycystic ovary syndrome Expression The lncRNA SRA expression is potentially associated with PCOS and it has positive correlation with obesity in PCOS N/A N/A N/A N/A Human N/A N/A 25609053 HIT breast cancer Regulation "LncRNA-HIT plays a significant role in regulation of EMT and breast cancer invasion and metastasis, and could be a potential therapeutic target in breast cancers." N/A N/A N/A N/A Human N/A N/A 25605728 MALAT1 renal cell carcinoma Regulation Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25600645 FR0348383 prostate cancer Expression "FR0348383 transcript in post-DRE urine may be a novel biomarker for detection of PCa with great diagnostic value, especially in the grey zone cohort." N/A N/A N/A N/A Human N/A N/A 25597901 MALAT1 osteosarcoma Regulation "The downregulation of MALAT-1 inhibited cell proliferation, migration, invasion and epithelial mesenchymal transition (EMT) processes in the E2-dose dependent and ER independent ways." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25592968 HULC hepatocellular carcinoma Locus "HULC functions as an oncogene in hepatoma cells, acting mechanistically by deregulating lipid metabolism through a signaling pathway involving miR-9, PPARA," chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 25592151 HOTAIR breast cancer Mutation "The CC genotype of HOTAIR rs920778 polymorphism might play important roles in genetic susceptibility to BC development and aggressiveness in a Turkish population," chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25586347 XIST glioblastoma Regulation Knockdown of long non-coding RNA XIST exerts tumor-suppressive functions in human glioblastoma stem cells by up-regulating miR 152. chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 25578780 CCAT1 gallbladder cancer Regulation Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p. chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 25569100 MEG3 pancreatic neuroendocrine tumor Regulation The epigenetic activation of lncRNA MEG3 and/or inactivation of c-MET could be therapeutic for treating PNETs and insulinomas. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 25565142 HOXA-AS3 glioma Expression Changes of this lncRNA expressions probably drivves malignant transformation. chr7 27140364 27155928 + Human HOXA6as NR_038832 25561975 BCYRN1 glioma Expression Changes of this lncRNA expressions probably drivves malignant transformation. chr2 47335315 47335514 + Human BC200; BC200a; LINC00004; NCRNA00004 NR_001568 25561975 CCAT1 gastric cancer Expression "CCAT1 is up-regulated in gastric cancer, and may serve as a potential bio-marker for early detection and surveillance." chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 25561974 TCONS_00032546 atrial fibrillation Expression "Dysregulated lncRNAs may play regulatory roles in AF neural remodeling, which may further provide potential therapeutic targets for prophylaxis and treatment of AF." N/A N/A N/A N/A Human N/A N/A 25559442 TCONS_00026102 atrial fibrillation Expression "Dysregulated lncRNAs may play regulatory roles in AF neural remodeling, which may further provide potential therapeutic targets for prophylaxis and treatment of AF." N/A N/A N/A N/A Human N/A N/A 25559442 lincRNA-TSPAN8 hepatocellular carcinoma Expression "LincRNA-TSPAN8 was found highly expressed in high lung metastatic potential HCC cells, while lowly expressed in no or low lung metastatic potential HCC cells" N/A N/A N/A N/A Human N/A N/A 25556502 RP5-1014O16.1 hepatocellular carcinoma Expression "RP5- 1014O16.1 was highly expressed in high lymphatic metastatic potential HCC cell lines, while lowly expressed in no lymphatic metastatic potential HCC cell lines." chrX 149758021 149758295 - Human AC244098.1 ENST00000436499 25556502 CTBP1-AS polycystic ovary syndrome Expression Abnormal CTBP1-AS expression is a risk factor for PCOS and it is a predictor of variability in serum TT level in Chinese women with PCOS. chr4 1210120 1218591 + Human PCAT10 NR_104331 25552498 LOC285194 pancreatic ductal adenocarcinoma Expression "Reduced LOC285194 in PDAC tissues was correlated with tumor progression, and lncRNA LOC285194 might be a potential molecular biomarker for predicting the prognosis of patients." N/A N/A N/A N/A Human N/A N/A 25550852 UCA1 esophageal squamous cell carcinoma Expression Overexpression of long non-coding RNA UCA1 predicts a poor prognosis in patients with esophageal squamous cell carcinoma. chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 25550835 HIF1A-AS1 thoracoabdominal aorta aneurysm Expression "HIF1a-AS1 was overexpressed in the thoracoabdominal aorta aneurysm and the interaction between HIF1a-AS1 and apoptotic proteins plays a key role in the proliferation and apoptosis of VSMCs in vitro, which may contribute to the pathogenesis of thoracoabdominal aorta aneurysm." chr14 61681041 61695823 - Human 5'aHIF-1A; 5'aHIF1alpha NR_047116 25550800 MALAT1 prostate cancer Regulation Reduced Sost expression in the tumor microenvironment may promote bone metastasis by up-regulating MALAT1 in prostate cancer. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 27600237 CDKN2B-AS1 hepatocellular carcinoma Regulation Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell proliferation by epigenetic silencing of KLF2 chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 27391317 HOTAIR cervical cancer Regulation HOTAIR enhanced aggressive biological behaviors and induced radio-resistance via inhibiting p21 in cervical cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25547435 MALAT1 colon cancer Regulation MALAT-1/Snail pathway plays a critical role in TADC-mediated cancer progression. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25546229 MALAT1 esophageal squamous cell carcinoma Regulation "Silencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25538231 LSINCT5 gastric cancer Expression LSINCT5 may represent a novel prognostic indicator and a target for gene therapy in gastrointestinal cancer chr5 2712591 2715237 - Human N/A NR_145480 25526476 MALAT1 prostate cancer Expression Urine MALAT-1 is a promising biomarker for predicting prostate cancer risk. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25526029 uc.343 osteoarthritis Regulation The lncRNA may be new biomarkers for diagnosis or novel therapeutic targets of OA. N/A N/A N/A N/A Human N/A N/A 25524778 NR_001284 Chronic thromboembolic pulmonary hypertension Regulation "The potential role of lncRNA is in the regulation of central process, including inflammatory response, response to endogenous stimulus and antigen processing and presentation" chr6 32008614 32012472 - Human TNXA ENST00000507684 25522749 HAGLR neuroblastoma Regulation "HOXD-AS1 controls expression levels of clinically significant protein-coding genes involved in angiogenesis and inflammation, the hallmarks of metastatic cancer." chr2 176173189 176188958 - Human HOXD-AS1; Mdgt NR_110460 25522241 NBAT1 neuroblastoma Regulation Loss of NBAT-1 contributes to aggressive neuroblastoma by increasing proliferation and impairing differentiation of neuronal precursors. chr6 22134602 22147193 - Human CASC14; NBAT-1 NR_034143 25517750 FOXCUT basal-like breast cancer Regulation "FOXCUT lncRNA may be functionally involved in the tumor progression of BLBCs through the regulation of its paired mRNA, FOXC1, demonstrating that FOXCUT may serve as a novel biomarker and therapeutic target in BLBCs." chr6 1605531 1607358 + Human LINC01379; TCONS_00011636 NR_125804 25516208 MDC1-AS1 bladder cancer Regulation It may participate in bladder cancer through up-regulation of its antisense tumor-suppressing gene MDC1. chr6 30703067 30713184 + Human MDC1-AS NR_133647 25514464 PCGEM1 prostate cancer Regulation "PCGEM1 reprograms the androgen network and the central metabolism in a tumor-specific way, making it a promising target for therapeutic intervention" chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 25512540 LINC01018 hepatocellular carcinoma Regulation SRHC is capable of inhibiting cancer proliferation and is down-regulated in tumors at least partly by DNA methylation. chr5 6582136 6588500 + Human SRHC NR_024423 25512078 CDKN2B-AS1 non-small cell lung cancer Regulation Long noncoding RNA ANRIL promotes non-small cell lung cancer cell proliferation and inhibits apoptosis by silencing KLF2 and P21 expression. chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 25504755 uc003wbd hepatocellular carcinoma Expression Both lncRNA-uc003wbd and lncRNA-AF085935 are able to be potential biomarkers for HCC and HBV screening. N/A N/A N/A N/A Human N/A N/A 25501706 AF085935 hepatocellular carcinoma Expression Both lncRNA-uc003wbd and lncRNA-AF085935 are able to be potential biomarkers for HCC and HBV screening. N/A N/A N/A N/A Human N/A N/A 25501706 SCHLAP1 prostate cancer Expression "SChLAP1 is a novel lncRNA that demonstrates outlier expression in a subset of prostate cancers, promotes tumor cell invasion and metastasis, and associates with lethal disease." chr2 180692104 180916939 + Human SCHLAP1 ENST00000629145 25499224 AK058003 gastric cancer Regulation AK058003 is frequently upregulated in GC samples and promotes GC migration and invasion in vivo and in vitro. N/A N/A N/A N/A Human N/A N/A 25499222 LEIGC gastric cancer Regulation LEIGC is a tumor-suppressing lncRNA in gastric cancer N/A N/A N/A N/A Human N/A N/A 25496320 HOTAIR lung cancer Expression The expression of HOTAIR is elevated in lung cancer and correlates with metastasis and poor prognosis chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25491133 uc002yug.2 esophageal squamous cell carcinoma Regulation LincRNA-uc002yug.2 might involve in AS of RUNX1/AML1 and serve as a predictor for esophageal cancer and prognosis. N/A N/A N/A N/A Human N/A N/A 25486427 MALAT1 pancreatic cancer Expression Overexpression of long non-coding RNA MALAT1 is correlated with clinical progression and unfavorable prognosis in pancreatic cancer. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25481511 MALAT1 renal clear cell carcinoma Regulation "LncRNA MALAT1 was a novel molecule involved in ccRCC progression, which provided a potential prognostic biomarker and therapeutic target." chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25480417 LINC00974 hepatocellular carcinoma Expression "The combination of Linc00974 and KRT19 may be novel indices for clinical diagnosis of tumor growth and metastasis in HCC, while Linc00974 may become a potential therapeutic target for the prevention of HCC progression." chr17 41549606 41554495 - Human N/A NR_038442 25476897 HOTAIR gastric cardia adenocarcinoma Expression HOTAIR may be a useful marker to predict the biological behavior of tumors and potentially a therapeutic target in GCA treatment. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25476857 AATBC bladder cancer Regulation Knockdown of a novel lincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer. chr21 43805758 43812567 - Human N/A NR_026961 25473900 UBE3A-ATS Angelman syndrome N/A Targeting the long non-coding RNA is a therapy for Angelman syndrome N/A N/A N/A N/A Human N/A N/A 25470045 IRAIN breast cancer Locus IRAIN lncRNA is a novel imprinted gene that is aberrantly regulated in breast cancer. chr15 98645863 98651221 - Human IGF1R-AS NR_126453 25465188 HOTAIR colorectal cancer Regulation It may participate in carcinogenesis by regulating protein coding genes involved in special biological process relevant to cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25456707 lncRNA-422 colorectal cancer Regulation It may participate in carcinogenesis by regulating protein coding genes involved in special biological process relevant to cancer N/A N/A N/A N/A Human N/A N/A 25456707 SCHLAP1 prostate cancer Expression SChLAP1 expression is a significantly prognostic for metastatic disease progression of prostate cancer. chr2 180692104 180916939 + Human SCHLAP1 ENST00000629145 25456366 UFC1 hepatocellular carcinoma Regulation "The lincRNA-UFC1, a target of microRNA 34a, promotes proliferation and reduces apoptosis in HCC cells to promote growth of xenograft tumors" N/A N/A N/A N/A Human N/A N/A 25449213 HOTAIR lung cancer Regulation A long noncoding RNA (lncRNA) that is induced by cigarette smoke extract (CSE) and experiments utilizing lncRNAs to integrate inflammation with the epithelial-mesenchymal transition (EMT) in human bronchial epithelial (HBE) cells. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25447409 MALAT1 colorectal cancer Regulation MALAT1 promotes colorectal cancer cell proliferation/migration/invasion via PRKA kinase anchor protein 9. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25446987 CASC2 glioma Regulation "CASC2 plays a tumor suppressive role in glioma via negative regulation of miR-21, which may be a novel therapeutic target for treating gliomas." chr10 118046821 118210153 + Human C10orf5 NR_026939 25446261 PCA3 prostate cancer Regulation Long noncoding RNA PCA3 gene promoter region is related to the risk of prostate cancer on Chinese males. chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 25445501 LINC01158 glioma Regulation Linc-POU3F3 may also have a crucial regulatory role in glioma progression. chr2 104805425 104853183 - Human PANTR1; linc-Brn1a; linc-POU3F3 NR_037883 25445282 BC040587 breast cancer Expression BC040587 expression was correlated with menopausal status and tumor differentiation N/A N/A N/A N/A Human N/A N/A 25435812 HIF2PUT osteosarcoma Regulation "The lncRNA HIF2PUT may be a novel regulatory factor of osteosarcoma stem cells, which may exert its function partly by controlling HIF-2α expression." N/A N/A N/A N/A Human N/A N/A 25434862 HOTAIR colorectal cancer Mutation Genetic variants in HOTAIR were associated with risk of colorectal cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25432874 MALAT1 osteosarcoma Regulation MALAT1 promotes the proliferation and metastasis of osteosarcoma cells chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25431257 HOTAIR osteoarthritis Regulation The lncRNA may be associated with the pathogenesis of OA chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25430712 GAS5 osteoarthritis Regulation The lncRNA may be associated with the pathogenesis of OA chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 25430712 PMS2L2 osteoarthritis Regulation The lncRNA may be associated with the pathogenesis of OA N/A N/A N/A N/A Human N/A N/A 25430712 RP11-445H22.4 osteoarthritis Regulation The lncRNA may be associated with the pathogenesis of OA chr20 44694892 44746021 - Human KCNK15-AS1 ENST00000427303 25430712 H19 osteoarthritis Regulation The lncRNA may be associated with the pathogenesis of OA chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 25430712 CTD-2574D22.4 osteoarthritis Regulation The lncRNA may be associated with the pathogenesis of OA chr16 29919634 29921905 - Human AC120114.2 ENST00000567795 25430712 HOTAIR glioblastoma Regulation HOTAIR promotes cell cycle progression in glioma as a result of the binding of its 5' domain to the PRC2 complex chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25428914 PCAT1 prostate cancer Regulation The long non-coding RNA PCAT-1 promotes prostate cancer cell proliferation through cMyc chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 25425964 HOTTIP hepatocellular carcinoma Regulation Overexpression of HOTTIP contributes to hepatocarcinogenesis by regulating the expression of its neighbouring protein-coding genes chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 25424744 LOC401317 nasopharyngeal carcinoma Regulation LOC401317 is directly regulated by p53 and exerts antitumor effects in HNE2 nasopharyngeal carcinoma cells. N/A N/A N/A N/A Human N/A N/A 25422887 R05532 colorectal cancer Expression LncRNA R05532 may be used as the predictive marker of radiosensitivity of colorectal cancer cells in patients with breast cancer N/A N/A N/A N/A Human N/A N/A 25421768 NEAT1 breast cancer Expression High tumor NEAT1 expression correlates with poor survival chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 25417700 NEAT1 prostate cancer Regulation NEAT1 drives oncogenic growth by altering the epigenetic landscape of target gene promoters to favour transcription chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 25415230 HULC pancreatic cancer Expression Long noncoding RNA HULC is a novel biomarker of poor prognosis in patients with pancreatic cancer chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 25412939 HOTAIR cervical cancer Expression HOTAIR may represent a novel biomarker for predicting recurrence and prognosis and serve as a promising therapeutic target in cervical cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25405331 EWSAT1 Ewing sarcoma Regulation EWSAT1 is a downstream target of EWS-FLI1 that facilitates the development of Ewing sarcoma via the repression of target genes chr15 69080850 69095824 + Human LINC00277; NCRNA00277; TMEM84 NR_026949 25401475 GHET1 bladder cancer Regulation GHET1 knockdown suppressed the proliferation and invasion of bladder cancer cells in vitro chr7 148987527 148989429 + Human lncRNA-GHET1 NR_130107 25400817 PVT1 non-small cell lung cancer Regulation Increased expression of the lncRNA PVT1 promotes tumorigenesis in non-small cell lung cancer chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 25400777 GAS5 cervical cancer Regulation "Knockdown of GAS5 promoted cell proliferation, migration, and invasion" chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 25400758 CYTOR gastric cancer Expression It has the possibility to be applied in gastric cancer diagnosis as a novel blood-based biomarker chr2 87455455 87521518 + Human C2orf59; LINC00152; NCRNA00152 NR_024204 25391424 ENSG00000261777 prostate cancer N/A It plays an important roles in prostate cancer chr16 70315640 70346747 - Human AC012184.3 ENST00000570278 25385343 2900055J20Rik left ventricular hypertrophy Expression It is a therapeutic target chr18 40256963 40257687 + Human 2900055J20Rik NR_045177 25382655 Gm14005 left ventricular hypertrophy Expression It is a therapeutic target chr2 128195993 128429349 - Mouse N/A ENSMUST00000125354 25382655 PAN Kaposi's sarcoma Regulation It is a multifunctional regulatory transcript that controls KSHV gene expression in Kaposi's sarcoma N/A N/A N/A N/A Human N/A N/A 25375885 MALAT1 multiple myeloma Expression MALAT1 long non-coding RNA is overexpressed in multiple myeloma and may serve as a marker to predict disease progression. chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25369863 HOTAIR cervical cancer Expression Circulating HOTAIR was commonly upregulated and a potent prognostic marker in cervical cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25366139 TUG1 esophageal squamous cell carcinoma Regulation TUG1 promotes proliferation and migration of ESCC cells and is a potential oncogene of ESCC chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 25366138 MALAT1 diabetic retinopathy Regulation "MALAT1 knockdown could regulate retinal endothelial cell proliferation, migration, and tube formation in vitro" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25356875 uc.283-plus glioma Regulation Uc.283-plus lncRNA might have a role in pluripotency of stem cells and in the biology of glioma N/A N/A N/A N/A Human N/A N/A 25352916 SPRY4-IT1 melanoma Regulation SPRY4-IT1 knockdown may induce apoptosis via lipin 2-mediated alterations in lipid metabolism leading to cellular lipotoxicity chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 25344859 HOTAIR endometrial cancer Expression Long noncoding RNA HOX transcript antisense intergenic RNA (HOTAIR) as a foe and novel potential therapeutic target for endometrial carcinoma chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25340288 SPRY4-IT1 renal clear cell carcinoma Expression High expression of long non-coding RNA SPRY4-IT1 predicts poor prognosis of clear cell renal cell carcinom chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 25337221 HOTAIR breast cancer Regulation HOTAIR-mediated regulation of gene expression and growth associated with the basal-like phenotype of breast cancer cells chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25328122 GAS5 colorectal cancer Regulation Long noncoding RNA GAS5 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 25326054 ENST00000480739 pancreatic ductal adenocarcinoma Regulation Downregulated ENST00000480739 in PDAC contributes to tumour metastasis and progression by regulating HIF-1 chr12 57674665 57675250 + Human RPL13AP23 ENST00000480739 25314054 HOTAIR breast cancer Regulation Nuclear factor of activated T cells 5 maintained by Hotair suppression of miR-568 upregulates S100 calcium binding protein A4 to promote breast cancer metastasis chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25311085 SPRY4-IT1 prostate cancer Regulation Knockdown of SPRY4-IT1 in PC3 cells inhibited cell proliferation and invasion and increased cell apoptosis chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 25307116 PTCSC2 papillary thyroid carcinoma Expression Forced expression of PTCSC2 in the BCPAP cell line affected the expression of a subset of noncoding and coding transcripts with enrichment of genes functionally involved in cell cycle and cancer chr9 97699625 97853080 - Human N/A NR_147055 25303483 HOTAIR esophageal squamous cell carcinoma Expression The lncRNA could be potential diagnostic and prognostic biomarkers for ESCC chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25297587 MGAT3-AS1 acute kidney injury Expression Circulating long noncoding RNA TapSaki is a predictor of mortality in critically ill patients with acute kidney injury chr22 39475807 39476822 - Human TapSAKI NR_126469 25294924 CERNA2 ovarian cancer Regulation LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b chr10 84167228 84172076 - Human HOST2; lncRNA-HOST2 NR_134505 25292198 BANCR papillary thyroid carcinoma Regulation "BANCR increases PTC cell proliferation, which could activate autophagy" chr9 69296681 69307056 - Human LINC00586 NR_047671 25289082 U79277 breast cancer Regulation The lncRNA may be implicated in breast cancer pathogenesis N/A N/A N/A N/A Human N/A N/A 25288503 AK024118 breast cancer Regulation The lncRNA may be implicated in breast cancer pathogenesis N/A N/A N/A N/A Human N/A N/A 25288503 BC040204 breast cancer Regulation The lncRNA may be implicated in breast cancer pathogenesis N/A N/A N/A N/A Human N/A N/A 25288503 AK000974 breast cancer Regulation The lncRNA may be implicated in breast cancer pathogenesis N/A N/A N/A N/A Human N/A N/A 25288503 RP11-296A18.3 intervertebral disc degeneration Expression "Up-regulated RP11-296A18.3 highly likely induced the over expression of FAF1, which eventually promoted the aberrant apoptosis of disc cells" chr1 51195095 51235096 - Human LINC01562 ENST00000366181 25280944 HOTAIR gastric cancer Expression "HOTAIR is a potential biomarker for identifying patients with peritoneal metastasis, and it is a novel therapeutic target in patients with gastric neoplasia" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25280565 GAPLINC gastric cancer Expression GAPLINC overexpression defines a subgroup of patients with gastric cancer with very poor survival. chr18 3466250 3478978 + Human LINC01540 NR_110428 25277524 MALAT1 pancreatic cancer Regulation "Elevated expression level of long noncoding RNA MALAT-1 facilitates cell growth, migration and invasion in pancreatic cancer" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25269958 AK023096 uterine leiomyomas Expression The aberrantly expressed lncRNA may contribute to the pathogenesis of uterine leiomyomas N/A N/A N/A N/A Human N/A N/A 25268745 MT1DP liver cancer Regulation "Tumor suppressor long non-coding RNA, MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver cancer cells" chr16 56643705 56644786 + Human MT1DP ENST00000463480 25261601 AC138128.1 gastric cancer Expression LncRNA AC138128.1 might be a novel biomarker for predicting GC N/A N/A N/A N/A Human N/A N/A 25260808 PVT1 gastric cancer Expression PVT1 is a new biomarker for human gastric cancer and may indicate lymph node invasion chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 25258543 LINC-ROR breast cancer Regulation LincRNA-RoR and miR-145 regulate invasion in triple-negative breast cancer via targeting ARF6. chr18 57054571 57072119 - Human ROR; lincRNA-RoR NR_048536 25253741 AC006050.3 lung squamous cell carcinoma Expression LncRNA AC006050.3-003 was a valuable biomarker N/A N/A N/A N/A Human N/A N/A 25250788 SNHG14 Prader-Willi syndrome N/A It plays an important role in PWS chr15 24823608 25419461 - Human 115HG; IC-SNURF-SNRPN; LNCAT; NCRNA00214; U-UBE3A-ATS; UBE3A-AS; UBE3A-AS1; UBE3AATS NR_146177 25246219 NEAT1 acute promyelocytic leukemia Regulation Reduced expression of the nuclear long noncoding RNA NEAT1 may play a role in the myeloid differentiation of APL cells chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 25245097 AC026166.2 laryngeal squamous cell carcinoma Expression AC026166.2-001 and RP11-169D4.1-001 may act as novel biomarkers in LSCC and may be potential therapeutic targets for LSCC patients chr3 12165299 12165642 - Human MTCO1P5 ENST00000433573 25243407 RP11-169D4.1 laryngeal squamous cell carcinoma Expression AC026166.2-001 and RP11-169D4.1-001 may act as novel biomarkers in LSCC and may be potential therapeutic targets for LSCC patients chr11 72570660 72573229 + Human LINC01537 ENST00000450804 25243407 LINC00582 endometrial cancer Regulation LincRNA-NR_034037 regulates TSNAX-DISC1 formation programs that tightly regulate EC development chr1 231591292 231612090 - Human N/A NR_034037 25239642 PCA3 prostate cancer Regulation It is a great biomarker with fairly high specificity and sensitivity chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 25232225 MALAT1 lung cancer brain metastasis Regulation "Increased level of long noncoding RNA MALAT1 promotes lung cancer brain metastasis by inducing EMT, which may be a promising prognosis factor and therapeutic target to treat lung cancer brain metastasis in future" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25217850 LET gallbladder cancer Expression LncRNA-LET overexpression conferred a proliferative advantage to tumor cells under hypoxic conditions. N/A N/A N/A N/A Human N/A N/A 25213660 H1.3 ovarian cancer Expression H1.3 overexpression and H19 knockdown synergistically decrease the growth rate of ovarian cancer cells. N/A N/A N/A N/A Human N/A N/A 25205099 MEG3 liver fibrosis Regulation MEG3 may play an important role in stellate cell activation and liver fibrosis progression and act as a novel potential therapeutic target for liver fibrosis. chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 25201080 BC008363 pancreatic ductal adenocarcinoma Expression LncRNA BC008363 may be a novel biomarker for the prognosis of pancreatic cancer N/A N/A N/A N/A Human N/A N/A 25200694 PCGEM1 prostate cancer Regulation "PCGEM1 inhibited tumor cell proliferation, migration, and invasion, and induced early apoptosis both in vitro." chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 25200485 GAS5 osteoarthritis Regulation GAS5 contributes to the pathogenesis of OA by acting as a negative regulator of miR-21 and thereby regulating cell survival chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 25196583 MALAT1 multiple myeloma Expression The role of MALAT1 in cellular transformation is pointing toward its potential use as a biomarker and a target for novel therapeutic approaches in multiple myeloma chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25187517 CCAT1 colon cancer Regulation CCAT1 promotes colon cancer cell proliferation and invasion chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 25185650 LOC285194 esophageal squamous cell carcinoma Expression "Decreased expression of LOC285194 could serve as a molecular markerto predict the clinical outcome of ESCC patients after surgery, and select patients who would benefit from preoperative CRT" N/A N/A N/A N/A Human N/A N/A 25169763 RCCRT1 renal cell carcinoma Regulation RCCRT1 promoted migration and invasion of RCC and that RCCRT1 may offer a biomarker to verdict prognosis as well as an attractive new target for prognostic and therapeutic intervention for RCC patients in the future. N/A N/A N/A N/A Human N/A N/A 25168566 FENDRR gastric cancer Regulation FENDRR plays an important role in the progression and metastasis of gastric cancer chr16 86474525 86508860 - Human FOXF1-AS1; TCONS_00024240; lincFOXF1; onco-lncRNA-21 NR_033925 25167886 XIST membranous nephropathy Expression Urinary Xist is a potential biomarker for membranous nephropathy chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 25157805 HOTAIR renal carcinoma Regulation Suppressed expression of long non-coding RNA HOTAIR inhibits proliferation and tumourigenicity of renal carcinoma cells chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25149152 LOC283177 diffuse large B-cell lymphoma N/A It plays an important role in DLBCL chr11 134436482 134505661 + Human N/A NR_033852 25133503 CCAT1 non-small cell lung cancer Expression CARLo-5 may represent a prognostic marker and a potential therapeutic target of NSCLC chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 25129441 lncRNA-FER1L4 gastric cancer Regulation It plays an important role in post-transcriptional regulation in cancer N/A N/A N/A N/A Human N/A N/A 25124853 UCA1 urinary bladder Expression UCA1 can be used as a non-invasive diagnostic biomarker for TCC bladder as an adjunct to cytology in the early diagnosis of primary urinary bladder cancer chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 25123267 NRIR HCV Regulation "LncRNA-CMPK2 was strongly upregulated in a subset of HCV-infected human livers, suggesting a role in modulation of the IFN response in vivo" chr2 6828554 6840464 - Human lncRNA-CMPK2 NR_126359 25122750 DIRC3 breast cancer Expression It is a potential target of breast cancer chr2 217284023 217756593 - Human N/A NR_026597 25122612 PVT1 breast cancer Expression It is a potential target of breast cancer chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 25122612 CCDC26 breast cancer Expression It is a potential target of breast cancer chr8 129351694 129680239 - Human RAM NR_130917 25122612 GAS5 hepatocellular carcinoma Expression Down-regulation of long non-coding RNA GAS5 is associated with the prognosis of hepatocellular carcinoma chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 25120813 HA117 Hirschsprung's disease Regulation HA117 may be a factor exerting an anti-differentiation or or anti-maturation role in the genesis of HSCR N/A N/A N/A N/A Human N/A N/A 25120773 NCRUPAR colorectal cancer Regulation Downregulation of a long noncoding RNA-ncRuPAR contributes to tumor inhibition in colorectal cancer chr5 76712403 76712888 + Human NCRNA00193; ncR-uPAR NR_028375 25119598 LCAL1 lung cancer Expression "The most differentially expressed lncRNA, LCAL1, plays a role in cellular proliferation" chr6 79307669 79313384 - Human onco-lncRNA-27 NR_130915 25116943 ZNRD1-AS1 hepatocellular carcinoma Expression Expression quantitative trait loci in long non-coding RNA ZNRD1-AS1 influence both HBV infection and hepatocellular carcinoma development N/A N/A N/A N/A Human N/A N/A 25110835 HOTAIR laryngeal squamous cell carcinoma Expression "Serum exosomal miR-21 and HOTAIR were significantly correlated with clinical parameters of LSCC, and combined evaluation of their serum expressions may be a valuable biomarker to screen LSCC and might be a promising predicting tool for LSCC patient" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25099764 LOC100132354 lung adenocarcinoma Regulation It may play a key role in tumor development N/A N/A N/A N/A Human N/A N/A 25089627 RPLP0P2 lung adenocarcinoma Regulation It may play a key role in tumor development chr11 61615036 61639449 + Human RPLP0P2 ENST00000496593 25089627 RP11-325I22.2 lung adenocarcinoma Regulation RP11-325I22.2 and LOC440905 might play an important role in the mechanism of EGFR exon 19 deletion in lung adenocarcinoma. chr3 1363582 1380067 - Human LINC01511 ENST00000629718 25085781 LOC440905 lung adenocarcinoma Regulation RP11-325I22.2 and LOC440905 might play an important role in the mechanism of EGFR exon 19 deletion in lung adenocarcinoma. N/A N/A N/A N/A Human N/A N/A 25085781 HOTAIR atypical teratoid rhabdoid tumor N/A It may play an important role in cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25085602 MALAT1 endometrioid endometrial carcinoma Regulation It contributes to EEC development chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25085246 LUNAR1 T cell acute lymphoblastic leukemia Regulation "LUNAR1, is required for efficient T-ALL growth in vitro and in vivo due to its ability to enhance IGF1R mRNA expression and sustain IGF1 signaling" chr15 99014704 99031050 + Human N/A NR_126487 25083870 SNAR colon cancer Regulation A long non-coding RNA snaR contributes to 5-fluorouracil resistance in human colon cancer cells N/A N/A N/A N/A Human N/A N/A 25078450 HOTAIR breast cancer Regulation "MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25070049 HOTAIR gastric adenocarcinoma Regulation "HOTAIR was involved in inhibition of apoptosis and promoted invasiveness, supporting a role for HOTAIR in carcinogenesis and progression of gastric cancer" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25063030 AK124939 pulmonary adenocarcinoma Regulation LncRNAs such as AK124939 may be anticancer factors related to the progression of pulmonary adenocarcinoma N/A N/A N/A N/A Human N/A N/A 25061321 91H colorectal cancer Regulation Up-regulation of 91H promotes tumor metastasis and predicts poor prognosis for patients with colorectal cancer N/A N/A N/A N/A Human N/A N/A 25058480 AF118081 lung cancer Regulation AF118081 knockdown inhibited cell growth and tumor invasion N/A N/A N/A N/A Human N/A N/A 25050996 lnc-MBL2-4:3 tongue squamous cell carcinoma Expression High level of lnc-MBL2-4:3 was significantly associated with the node positive tongue SCC patients N/A N/A N/A N/A Human N/A N/A 25045670 lnc-STXBP5-1 tongue squamous cell carcinoma Regulation LncRNA deregulation was involved in the pathogenesis of tongue SCC N/A N/A N/A N/A Human N/A N/A 25045670 PVT1 hepatocellular carcinoma Regulation Regulation of the lncRNA-hPVT1/NOP2 pathway may have beneficial effects on the treatment of HCC chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 25043274 MALAT1 non-small cell lung cancer Regulation "Besides tumor histology, prognostic impact of Bcl-2 was also found to depend on MALAT-1 lncRNA expression" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25036876 CDKN2B-AS1 acute myocardial infarction Expression "ANRIL and KCNQ1OT1 improved the prediction of left ventricular dysfunction by a model, including demographic features, clinical parameters, and cardiac biomarkers." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 25035150 KCNQ1OT1 acute myocardial infarction Expression "ANRIL and KCNQ1OT1 improved the prediction of left ventricular dysfunction by a model, including demographic features, clinical parameters, and cardiac biomarkers." chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 25035150 SCHLAP1 prostate cancer Regulation The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex chr2 180692104 180916939 + Human SCHLAP1 ENST00000629145 25035039 MALAT1 colorectal cancer Expression High expression of lncRNA MALAT1 suggests a biomarker of poor prognosis in colorectal cancer chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25031737 TSLC1-AS1 glioma Regulation LncRNA TSLC1-AS1 is a novel tumor suppressor in glioma N/A N/A N/A N/A Human N/A N/A 25031725 FOXCUT esophageal squamous cell carcinoma Regulation A novel long non-coding RNA FOXCUT and mRNA FOXC1 pair promote progression and predict poor prognosis in esophageal squamous cell carcinoma chr6 1605531 1607358 + Human LINC01379; TCONS_00011636 NR_125804 25031703 CADM1-AS1 renal clear cell carcinoma Expression CADM1-AS1 may be a potential biomarker and therapeutic target in patients with ccRCC N/A N/A N/A N/A Human N/A N/A 25031695 HOTAIR bladder cancer Expression Upregulation of the long noncoding RNA HOTAIR predicts recurrence in stage Ta/T1 bladder cancer. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25030736 PCAT29 prostate cancer Regulation The lncRNA PCAT29 inhibits oncogenic phenotypes in prostate cancer chr15 69592200 69695750 + Human N/A NR_126437 25030374 CAI2 neuroblastoma Regulation "CAI2 contributes to the paradoxical overexpression of p16 in neuroblastoma, where CAI2 may offer a useful biomarker of high-risk disease" N/A N/A N/A N/A Human N/A N/A 25028366 MIR99AHG myeloid leukemia Regulation LncRNAs MONC and MIR100HG are regulators of hematopoiesis and oncogenes in the development of myeloid leukemia chr21 16070488 16631727 + Human C21orf34; C21orf35; LINC00478; MONC NR_136550 25027842 MIR100HG myeloid leukemia Regulation LncRNAs MONC and MIR100HG are regulators of hematopoiesis and oncogenes in the development of myeloid leukemia chr11 122089103 122203062 - Human AGD1; linc-NeD125; lncRNA-N2 NR_137175 25027842 MALAT1 colorectal cancer Expression MALAT1 might be a potential predictor for tumour metastasis and prognosis chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 25025966 BC017743 hepatocellular carcinoma Regulation It provide important insight about the lncRNAs in HCC pathogenesis N/A N/A N/A N/A Human N/A N/A 25025236 ENST00000395084 hepatocellular carcinoma Regulation It provide important insight about the lncRNAs in HCC pathogenesis N/A N/A N/A N/A Human N/A N/A 25025236 ZNF674-AS1 hepatocellular carcinoma Regulation It provide important insight about the lncRNAs in HCC pathogenesis chrX 46545490 46548475 + Human N/A NR_015378 25025236 PRR26 hepatocellular carcinoma Regulation It provide important insight about the lncRNAs in HCC pathogenesis chr10 649948 665169 + Human C10orf108 NR_027151 25025236 AK056988 hepatocellular carcinoma Regulation It provide important insight about the lncRNAs in HCC pathogenesis N/A N/A N/A N/A Human N/A N/A 25025236 uc003yqb.1 hepatocellular carcinoma Regulation It provide important insight about the lncRNAs in HCC pathogenesis N/A N/A N/A N/A Human N/A N/A 25025236 LINC01080 Alzheimer's disease Mutation "single-nucleotide polymorphisms (SNPs) of long intergenic noncoding RNA (lincRNA) at the genome level indicated that a genetic variant, rs7990916, in the lincRNA 01080 (linc01080) may play an important role in the physiology and pathophysiology of the human brain." chr13 80011077 80026663 + Human TCONS_00021856 NR_104138 25019275 UCA1 bladder cancer Regulation Hsa-miR-1 plays a tumor suppressive role via downregulating lncRNA UCA1 in bladder cancer chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 25015192 BANCR colorectal cancer Regulation BANCR contributes to colorectal cancer migration by inducing epithelial-mesenchymal transition chr9 69296681 69307056 - Human LINC00586 NR_047671 25013510 URHC hepatocellular carcinoma Regulation Long non-coding RNA URHC regulates cell proliferation and apoptosis via ZAK through the ERK/MAPK signaling pathway in hepatocellular carcinoma N/A N/A N/A N/A Human N/A N/A 25013376 HOTAIR lung cancer Expression "HOTAIR is overexpressed in metastatic lung cancer tissue, which is prospectively associated with the ability of HOTAIR to promote lung cancer cell motility and invasion" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 25010625 AK307796 colorectal cancer Regulation It may exert a partial or key role in the progress of lymph nodes metastasis of CRC N/A N/A N/A N/A Human N/A N/A 25009386 ENST00000425785 colorectal cancer Regulation It may exert a partial or key role in the progress of lymph nodes metastasis of CRC chr1 97545701 97546958 + Human SEC63P1 ENST00000425785 25009386 AK021444 colorectal cancer Regulation It may exert a partial or key role in the progress of lymph nodes metastasis of CRC N/A N/A N/A N/A Human N/A N/A 25009386 HOXB-AS3 colorectal cancer Regulation It may exert a partial or key role in the progress of lymph nodes metastasis of CRC chr17 48590420 48606414 + Human N/A NR_033205 25009386 EBIC cervical cancer Locus "LncRNA-EBIC was an oncogenic lncRNA, which could promote tumor cell invasion in CC by binding to EZH2 and inhibiting E-cadherin expression" N/A N/A N/A N/A Human N/A N/A 25007342 SOX2-OT breast cancer Expression SOX2OT plays a key role in the induction and/or maintenance of SOX2 expression in breast cancer chr3 181056680 181742228 + Human NCRNA00043; SOX2OT NR_075089 25006803 VTRNA2-1 gastric cancer Regulation Nc886 is a putative tumor suppressor and could potentially be used as a diagnostic marker in gastric cancer chr5 136080491 136080598 - Human CBL-3; CBL3; MIR886; MIRN886; VTRNA2; hsa-mir-886; hvg-5; nc886; svtRNA2-1a NR_030583 25003254 UCA1 bladder cancer Regulation UCA1 promotes bladder cancer cell proliferation by inhibiting BRG1 chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24993775 H19 prostate cancer Regulation "The H19-miR-675 axis acts as a suppressor of prostate cancer metastasis, which may have possible diagnostic and therapeutic potential for advanced prostate cancer" chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24988946 AA174084 gastric cancer Expression AA174084 may have potential as marker for the early diagnosis of GC N/A N/A N/A N/A Human N/A N/A 24986041 ABHD11-AS1 gastric cancer Expression ABHD11-AS1 might be a potential biomarker for diagnosis of gastric cancer chr7 73735069 73736000 + Human LINC00035; NCRNA00035; WBSCR26 NR_026690 24984296 UCA1 colorectal cancer Regulation "UCA1, a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution" chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24977734 BACE1-AS Alzheimer's disease Expression Downregulation of lncRNA BACE1-AS expression in SH-SY5Y cells by siRNA silencing resulted in the attenuation of the ability of BACE1 to cleave APP and delayed the induction of SP formation in the SP AD SHSY5Y cell model N/A N/A N/A N/A Human N/A N/A 24970022 AC130710 gastric cancer Expression LncRNA-AC130710 targeting by miR-129-5p is upregulated in gastric cancer and associates with poor prognosis chr2 16050427 16085801 + Human GACAT3 ENST00000442387 24969565 SPRY4-IT1 non-small cell lung cancer Expression SPRY4-IT1 could be a biomarker for poor prognosis of NSCLC chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 24967960 BANCR melanoma Regulation Long non-coding RNA BANCR promotes proliferation in malignant melanoma by regulating MAPK pathway activation chr9 69296681 69307056 - Human LINC00586 NR_047671 24967732 HMlincRNA717 gastric cancer Regulation LncRNA-HMlincRNA717 may play crucial roles during cancer occurrence and progression and may be a new potential biomarker of early gastric cancer N/A N/A N/A N/A Human N/A N/A 24961350 MRUL gastric cancer Regulation MRUL promotes ABCB1 expression and is a potential target to reverse the MDR phenotype of GC MDR cell sublines N/A N/A N/A N/A Human N/A N/A 24958102 HOTAIR gallbladder cancer Regulation "Long non-coding RNA HOTAIR, a c-Myc activated driver of malignancy, negatively regulates miRNA-130a in gallbladder cancer" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24953832 HOTAIR gastric cancer Regulation HOTAIR expression is modulated during gastric cancer progression and therefore may participate in molecular processes relevant to malignant transformation and metastasis in gastric carcinoma. chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24949306 H19 hepatocellular carcinoma Regulation Inhibition of LncRNAH19 and miR-675 expression can promote migration and invasion of HCC cells via AKT/GSK-3β/Cdc25A signaling pathway chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24939300 HOTAIR renal cell carcinoma Regulation "HOTAIR expression is correlated with the migration of RCC cells, and HOTAIR may be involved in the curcumin-induced inhibition of RCC metastasis" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24935377 MALAT1 cervical cancer Regulation MALAT1 was able to promote cell migration and proliferation chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24932303 TRPM2-AS prostate cancer Regulation TRPM2-AS knockdown led to PCa cell apoptosis chr21 44414590 44425563 - Human TRPM2-AS1 NR_109964 24931166 SOX2-OT lung cancer Regulation "Sox2ot plays an important role in regulating lung cancer cell proliferation, and may represent a novel prognostic indicator for the disease." chr3 181056680 181742228 + Human NCRNA00043; SOX2OT NR_075089 24927902 GAS5 colorectal cancer Expression GAS5-derived snoRNA expression was induced by DNA damage in a p53-dependent manner in colorectal cancer cell lines and their levels were not affected by DICER chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 24926850 PVT1 pleural mesothelioma Regulation "PVT1 CNG promotes a malignant phenotype of MPM, with C-MYC CNG stimulating cell proliferation and PVT1 both stimulating proliferation and inhibiting apoptosis" chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 24926545 MALAT1 glioma Regulation It contributes to glioma development chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24926466 PRNCR1 glioma Regulation It contributes to glioma development chr8 127079874 127092595 + Human CARLo-3; PCAT8 NR_109833 24926466 PCGEM1 glioma Regulation It contributes to glioma development chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 24926466 H19 glioma Regulation It contributes to glioma development chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24926466 HOTAIR glioma Regulation It contributes to glioma development chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24926466 LINC-ROR breast cancer Regulation LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis chr18 57054571 57072119 - Human ROR; lincRNA-RoR NR_048536 24922071 H19 pancreatic cancer Regulation H19 promotes pancreatic cancer metastasis by derepressing let-7's suppression on its target HMGA2-mediated EMT chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24920070 LINC-ROR hepatocellular carcinoma N/A "Extracellular vesicle lncRNA as mediators of the chemotherapeutic response, and support targeting linc-ROR to enhance chemosensitivity in HCC" chr18 57054571 57072119 - Human ROR; lincRNA-RoR NR_048536 24918061 MALAT1 osteosarcoma Regulation Knockdown of the putative Myc-6 target MALAT1 encoding long noncoding RNA remarkably impaired cell growth of MG63 cells chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24918046 RP11-462C24.1 colorectal cancer Expression Low expression of novel lncRNA RP11-462C24.1 suggests a biomarker of poor prognosis in colorectal cancer N/A N/A N/A N/A Human N/A N/A 24908062 MYCNUT neuroblastoma Regulation The important roles of lncUSMycN and NonO in regulating N-Myc expression and neuroblastoma oncogenesis and provide the first evidence that amplification of long noncoding RNA genes can contribute to tumorigenesis. chr2 15920399 15936018 + Human MYCNUN; lncUSMycN NR_125783 24906397 CDKN2B-AS1 atherosclerosis N/A It plays an important role in atherosclerosis chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24893939 UCA1 melanoma Expression Increased expression of UCA1 and Malat-1 lncRNAs might have a correlation with melanoma metastasis chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24892958 MALAT1 melanoma Expression Increased expression of UCA1 and Malat-1 lncRNAs might have a correlation with melanoma metastasis chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24892958 FOXCUT oral squamous cell carcinoma Regulation It may be functionally involved in the tumor progression of OSCC chr6 1605531 1607358 + Human LINC01379; TCONS_00011636 NR_125804 24889262 GAS5 pleural mesothelioma Expression "GAS5 levels modify cell proliferation in vitro, and that GAS5 expression in MPM tissue is associated with cell quiescence and podoplanin expression support a role of GAS5 in MPM biology" chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 24885398 GAS5 gastric cancer Expression Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 24884417 CASC22 breast cancer Locus The lincRNA-ENST00000515084 exon may be a genetic modifier in the development of breast cancer chr16 52258564 52280299 + Human LINC01373; LincRNA-ENST00000515084; TCONS_00024290 NR_135281 24879036 TCONS_00018278 hepatocellular carcinoma Expression These lncRNAs provided useful information for exploring potential therapeutic targets and diagnostic biomarkers of this cancer N/A N/A N/A N/A Human N/A N/A 24876753 AK093543 hepatocellular carcinoma Expression These lncRNAs provided useful information for exploring potential therapeutic targets and diagnostic biomarkers of this cancer N/A N/A N/A N/A Human N/A N/A 24876753 D16366 hepatocellular carcinoma Expression These lncRNAs provided useful information for exploring potential therapeutic targets and diagnostic biomarkers of this cancer N/A N/A N/A N/A Human N/A N/A 24876753 ENST00000501583 hepatocellular carcinoma Expression These lncRNAs provided useful information for exploring potential therapeutic targets and diagnostic biomarkers of this cancer N/A N/A N/A N/A Human N/A N/A 24876753 MALAT1 hepatocellular carcinoma Expression These lncRNAs provided useful information for exploring potential therapeutic targets and diagnostic biomarkers of this cancer chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24876753 HIF1A-AS1 aortic aneurysm Expression BRG1 expression is increased in thoracic aortic aneurysms and regulates proliferation and apoptosis of vascular smooth muscle cells through the long non-coding RNA HIF1A-AS1 in vitro chr14 61681041 61695823 - Human 5'aHIF-1A; 5'aHIF1alpha NR_047116 24875884 Smad7 breast cancer Regulation Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells N/A N/A N/A N/A Mouse N/A N/A 24863656 MEG3 epithelial ovarian cancer Regulation "MEG3 is epigenetically silenced in EOC due to promoter hypermethylation, which may contribute to the development of EOC" chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24859196 MALAT1 gastric cancer Regulation MALAT1 promotes cell proliferation in gastric cancer by recruiting SF2/ASF chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24857172 TUG1 non-small cell lung cancer Regulation "P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer," chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 24853421 HOTAIR colon cancer Expression "HOTAIR may also be a valuable predictor for colon cancer management; furthermore, this lncRNA may be a potential target for cancer prevention and treatment" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24840737 BGLT3 chronic myeloid leukemia Regulation LncRNA-BGL3 is regulated in the leukemic cells and showed that Bcr-Abl repressed lncRNA-BGL3 expression through c-Myc-dependent DNA methylation chr11 5244554 5245546 - Human BGL3; LINC01083; lncRNA-BGL3 NR_121648 24837367 PCA3 prostate cancer Expression "They are highly prostate-specific, posing as attractive biomarkers" chr9 76764436 76787569 + Human DD3; NCRNA00019; PCAT3 NR_132312 24836411 PCGEM1 prostate cancer Expression "They are highly prostate-specific, posing as attractive biomarkers" chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 24836411 PCAT1 prostate cancer Expression "They are highly prostate-specific, posing as attractive biomarkers" chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 24836411 ADAMTS9-AS2 glioma Regulation ADAMTS9-AS2 is a novel tumor suppressor modulated by DNMT1 in glioma. LncRNA ADAMTS9-AS2 may serve as a potential biomarker and therapeutic target for glioma chr3 64684870 65011468 + Human N/A NR_038264 24833086 HOTAIRM1 promyelocytic leukemia Regulation HOTAIRM1 provides a regulatory link in myeloid maturation by modulating integrin-controlled cell cycle progression at the gene expression level. chr7 27096094 27100258 + Human HOXA-AS1; HOXA1-AS1; NCRNA00179 NR_038367 24824789 LINC01315 nasopharyngeal carcinoma Expression High levels of lnc-C22orf32-1 and lnc-AL355149.1-1 were significantly associated with the male patients chr22 42364400 42369208 - Human lnc-C22orf32-1 NR_120596 24822202 lnc-AL355149.1-1 nasopharyngeal carcinoma Expression High levels of lnc-C22orf32-1 and lnc-AL355149.1-1 were significantly associated with the male patients N/A N/A N/A N/A Human N/A N/A 24822202 lnc-ZNF674-1 nasopharyngeal carcinoma Expression Increased expression of lnc-ZNF674-1 was associated with advanced tumor stages. N/A N/A N/A N/A Human N/A N/A 24822202 NCRUPAR gastric cancer Regulation NcRuPAR inhibits gastric cancer progression by down-regulating protease-activated receptor-1 chr5 76712403 76712888 + Human NCRNA00193; ncR-uPAR NR_028375 24817013 IPW Prader-Willi syndrome Regulation "It is a regulator of the DLK1-DIO3 region, as its overexpression in PWS and parthenogenetic iPSCs resulted in downregulation of MEGs in this locus" chr15 25116545 25122476 + Human NCRNA00002 NR_023915 24816254 MALAT1 pancreatic ductal adenocarcinoma Expression MALAT1 might be considered as a potential prognostic indicator and may be a target for diagnosis and gene therapy for PDAC chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24815433 FAS-AS1 non-Hodgkin's lymphomas N/A It plays an important role in non-Hodgkin's lymphomas chr10 88991422 88992975 - Human FAS-AS; FASAS; SAF NR_028371 24811343 SPRY4-IT1 esophageal squamous cell carcinoma Regulation Long noncoding RNA SPRY4-IT1 is upregulated in esophageal squamous cell carcinoma and associated with poor prognosis chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 24810925 H19 gastric cancer Regulation Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24810858 CDKN2B-AS1 gastric cancer Expression Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24810364 AK123657 colorectal cancer Expression "Three dysregulated lncRNAs, AK123657, BX648207 and BX649059 were required for efficient invasion and proliferation suppression in CRC cell lines" N/A N/A N/A N/A Human N/A N/A 24809982 BX648207 colorectal cancer Expression "Three dysregulated lncRNAs, AK123657, BX648207 and BX649059 were required for efficient invasion and proliferation suppression in CRC cell lines" N/A N/A N/A N/A Human N/A N/A 24809982 BX649059 colorectal cancer Expression "Three dysregulated lncRNAs, AK123657, BX648207 and BX649059 were required for efficient invasion and proliferation suppression in CRC cell lines" N/A N/A N/A N/A Human N/A N/A 24809982 CAHM colorectal cancer N/A "CAHM, a long non-coding RNA gene hypermethylated in colorectal neoplasia" chr6 163413065 163413950 - Human LINC00468 NR_037593 24799664 MVIH non-small cell lung cancer Regulation Long non-coding RNA MVIH indicates a poor prognosis for non-small cell lung cancer and promotes cell proliferation and invasion N/A N/A N/A N/A Human N/A N/A 24793017 GAS5 breast cancer Expression Reduced GAS5 expression attenuates apoptosis induction by classical chemotherapeutic agents in breast cancer cells chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 24789445 PVT1 breast cancer Locus The GG genotype of SNP rs13281615 plays a role in breast cancer likely by influencing PVT1 expression chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 24780616 HOTAIR gastric cancer Regulation LncRNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24775712 ATB hepatocellular carcinoma Regulation "LncRNA-ATB, a mediator of TGF-β signaling, could predispose HCC patients to metastases and may serve as a potential target for antimetastatic therapies" N/A N/A N/A N/A Human N/A N/A 24768205 H19 hepatocellular carcinoma Regulation Aflatoxin B1 promotes cell growth and invasion in hepatocellular carcinoma HepG2 cells through H19 and E2F1 chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24761865 HOTAIR endometrial cancer Regulation HOTAIR plays an important role in the carcinogenesis of endometrial cancer. Targeting HOTAIR may be a novel therapeutic strategy for endometrial cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24758900 MALAT1 hepatocellular carcinoma Regulation MALAT1 and HOTAIR play important role in the pathophysiology of hepatocellular carcinoma chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24757675 HOTAIR hepatocellular carcinoma Regulation MALAT1 and HOTAIR in the pathophysiology of hepatocellular carcinoma chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24757675 lncRNA-CIR osteoarthritis Regulation LncRNA-CIR contributes to ECM degradation and plays a key role in the pathogenesis of OA N/A N/A N/A N/A Human N/A N/A 24757148 RUNXOR hematopoietic malignancies Regulation RUNXOR noncoding RNA may function as a previously unidentified candidate component that is involved in chromosomal translocation in hematopoietic malignancies N/A N/A N/A N/A Human N/A N/A 24752773 HOTAIR cervical cancer Expression Overexpression of long noncoding RNA HOTAIR predicts a poor prognosis in patients with cervical cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24748337 CDKN2B-AS1 esophageal squamous cell carcinoma Regulation The significant role of ANRIL is in the occurrence and development of ESCC through TGFβ1 signaling pathways chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24747824 MALAT1 lung cancer Regulation The long noncoding RNA MALAT1 induces lung cancer cell migration and plays a pivotal role in lung cancer metastasis chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24742640 UCA1 bladder cancer Regulation "Urothelial carcinoma associated 1 is a hypoxia-inducible factor-1α-targeted long noncoding RNA that enhances hypoxic bladder cancer cell proliferation, migration, and invasion" chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24737584 HOTAIR rheumatoid arthritis Expression PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24722995 ACTA2-AS1 lung adenocarcinoma Regulation Enhanced expression of long non-coding RNA ZXF1 promoted the invasion and metastasis in lung adenocarcinoma chr10 88932684 88939974 + Human ZXF1; uc001kfo.1 NR_125373 24721325 CARL myocardial infarction Expression Modulation of its level may provide a new approach for tackling apoptosis and myocardial infarction N/A N/A N/A N/A Human N/A N/A 24710105 WT1-AS primary myelofibrosis Expression "Abnormal expression patterns of WT1-as, MEG3 and ANRIL long non-coding RNAs in CD34+ cells from patients with primary myelofibrosis and their clinical correlations." chr11 32435518 32458769 + Human WIT-1; WIT11; WT1AS; WT1-AS NR_120546 24707949 MEG3 primary myelofibrosis Expression "Abnormal expression patterns of WT1-as, MEG3 and ANRIL long non-coding RNAs in CD34+ cells from patients with primary myelofibrosis and their clinical correlations." chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24707949 CDKN2B-AS1 primary myelofibrosis Expression "Abnormal expression patterns of WT1-as, MEG3 and ANRIL long non-coding RNAs in CD34+ cells from patients with primary myelofibrosis and their clinical correlations." chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24707949 91H esophageal squamous cell carcinoma Regulation Long non-coding RNA 91H contributes to the occurrence and progression of esophageal squamous cell carcinoma by inhibiting IGF2 expression N/A N/A N/A N/A Human N/A N/A 24706416 PCNA-AS1 hepatocellular carcinoma Regulation Antisense long non-coding RNA PCNA-AS1 promotes tumor growth by regulating proliferating cell nuclear antigen in hepatocellular carcinoma. chr20 5119586 5119969 + Human PCNA-AS; PCNAAS NR_028370 24704293 GAS5 mantle cell lymphoma Regulation Stimulation of expression of candidate tumor suppressor GAS5 is responsible for much of the cytotoxic and cytostatic effects of rapalogues in MCL chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 24703244 LINC00963 prostate cancer Regulation Linc00963 was involved in the prostate cancer transition from androgen-dependent to androgen-independent and metastasis via the EGFR signaling pathway chr9 129488660 129513686 + Human N/A NR_038955 24691949 H19 gastric cancer Regulation H19 affects cell proliferation and predicts a poor prognosis in patients with gastric cancer chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24671855 TUSC8 cervical cancer Expression Low expression of long noncoding XLOC_010588 indicates a poor prognosis and promotes proliferation through upregulation of c-Myc in cervical cancer chr13 44400250 44405984 - Human LINC01071; XLOC_010588 NR_104174 24667250 LIPCAR heart failure Expression LIPCAR is a novel biomarker of cardiac remodeling and predicts future death in patients with heart failure N/A N/A N/A N/A Human N/A N/A 24663402 HOTAIR hepatocellular carcinoma Regulation HOTAIR promotes cell migration and invasion via down-regulation of RNA binding motif protein 38 in hepatocellular carcinoma cells chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24663081 HOTAIR ovarian cancer Expression HOTAIR plays a vital role in EOC metastasis and could represent a novel prognostic marker and potential therapeutic target in patients with EOC chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24662839 MALAT1 gallbladder cancer Locus MALAT1 might serve as an oncogenic lncRNA that promotes proliferation and metastasis of GBC and activates the ERK/MAPK pathway chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24658096 BANCR non-small cell lung cancer Regulation "BANCR actively functions as a regulator of EMT during NSCLC metastasis, suggesting that BANCR could be a biomarker for poor prognosis of NSCLC" chr9 69296681 69307056 - Human LINC00586 NR_047671 24655544 UCA1 bladder cancer Regulation It plays a pivotal role in bladder cancer progression and metastasis chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24648007 LOC554202 breast cancer Regulation Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells N/A N/A N/A N/A Human N/A N/A 24631686 LINC01158 esophageal squamous cell carcinoma Regulation This noncoding RNA contributes to the development of ESCC by interacting with EZH2 to promote methylation of POU3F3 chr2 104805425 104853183 - Human PANTR1; linc-Brn1a; linc-POU3F3 NR_037883 24631494 TDRG1 gastric cancer N/A It plays an important role in gastric cancer chr6 40378424 40379892 + Human LINC00532 NR_024015 24595048 HOTAIR small cell lung cancer Regulation "HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24591352 LINC-ROR endometrial cancer Regulation Linc-RoR has an important role during endometrial carcinogenesis chr18 57054571 57072119 - Human ROR; lincRNA-RoR NR_048536 24589415 LINC00467 neuroblastoma Expression Knocking-down linc00467 expression with siRNA in neuroblastoma cells reduced the number of viable cells and increased the percentage of apoptotic cells chr1 211382755 211432535 + Human C1orf97 NR_026761 24586304 HOTAIR colorectal cancer Expression "HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24583926 CHRF cardiac hypertrophy Regulation CHRF regulates cardiac hypertrophy by targeting miR-489 N/A N/A N/A N/A Human N/A N/A 24557880 HOTAIR breast cancer Expression Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24533973 MALAT1 breast cancer Regulation "MALAT-1 decreasing by knocking down showed similar effects on proliferation, migration and invasion" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24525122 CYTOR gastric cancer Expression LincRNA LINC00152 might be a novel biomarker for predicting gastric cancer chr2 87455455 87521518 + Human C2orf59; LINC00152; NCRNA00152 NR_024204 24523021 ENST00000435885 oesophageal squamous cell carcinoma Expression "The three-lncRNA signature is a new biomarker for the prognosis of patients with OSCC, enabling more accurate prediction of survival" N/A N/A N/A N/A Human N/A N/A 24522499 LINC01233 oesophageal squamous cell carcinoma Expression "The three-lncRNA signature is a new biomarker for the prognosis of patients with OSCC, enabling more accurate prediction of survival" chr19 22532626 22533494 + Human XLOC_013014 NR_110664 24522499 LINC01234 oesophageal squamous cell carcinoma Expression "The three-lncRNA signature is a new biomarker for the prognosis of patients with OSCC, enabling more accurate prediction of survival" chr12 113744577 113773683 - Human LCAL84; onco-lncRNA-32 NR_110026 24522499 PCAT18 prostate cancer Expression PCAT18 is a potential therapeutic target and biomarker for metastatic PCa chr18 26687621 26703638 - Human LINC01092 NR_024259 24519926 MEG3 gastric cancer Regulation The long non-coding RNA MEG3 was reported to be a tumor suppressor in a number of malignant tumors including gastric cancer chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24515776 MALAT1 bladder cancer Regulation Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long noncoding RNA MALAT1 chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24512851 CCAT2 non-small cell lung cancer Regulation CCAT2 is a lung adenocarcinoma-specific lncRNA and promotes invasion of NSCLC and highlight its potential as a biomarker for lymph node metastasis chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 24504682 UCA1 bladder cancer Regulation "UCA1 increases the cisplatin resistance of bladder cancer cells by enhancing the expression of Wnt6, and thus represents a potential target to overcome chemoresistance in bladder cancer." chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24495014 MEG3 pituitary adenoma Expression MEG3 and HOTAIR expression may correlate with NFPA development and invasion chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24469926 HOTAIR pituitary adenoma Expression MEG3 and HOTAIR expression may correlate with NFPA development and invasion chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24469926 lincRNA1611 pancreatic ductal adenocarcinoma Expression LincRNA1611 and Ppp3ca were high expression in PDAC and may serve as new potential targets for intervention of the disease N/A N/A N/A N/A Human N/A N/A 24469904 Ppp3ca pancreatic ductal adenocarcinoma Expression LincRNA1611 and Ppp3ca were high expression in PDAC and may serve as new potential targets for intervention of the disease N/A N/A N/A N/A Human N/A N/A 24469904 H19 glioma Regulation H19 promotes glioma cell invasion by deriving miR-675 chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24466011 UCA1 breast cancer Regulation UCA1 promotes breast tumor growth by suppression of p27 (Kip1) chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24457952 MALAT1 bladder cancer Regulation Malat1 inhibition may represent a promising therapeutic option for suppressing bladder cancer progression chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24449823 MALAT1 diabetic retinopathy Expression "MALAT1, a conserved lncRNA, may become a potential therapeutic target for the prognosis, diagnosis, and treatment of DR" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24436191 PRNCR1 prostate cancer Regulation It determine androgen receptor dependent gene expression in prostate cancer growth in vivo chr8 127079874 127092595 + Human CARLo-3; PCAT8 NR_109833 24435053 PCGEM1 prostate cancer Regulation It determine androgen receptor dependent gene expression in prostate cancer growth in vivo chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 24435053 GHET1 gastric cancer Regulation GHET1 plays a pivotal role in gastric carcinoma cell proliferation via increasing c-Myc mRNA stability and expression chr7 148987527 148989429 + Human lncRNA-GHET1 NR_130107 24397586 MALAT1 bladder cancer Regulation Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long non-coding RNA MALAT1 chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24396870 ZNF300P1 ovarian cancer Regulation "ZNF300P1 lincRNA expression is regulating cell polarity, motility, and adhesion and loss of expression may contribute to the metastatic potential of ovarian cancer cells" chr5 150930645 150946289 - Human ZNF300P1 ENST00000356555 24393131 H19 gastric cancer Regulation The novel pathway H19/miR-675/RUNX1 regulates gastric cancer development and may serve as a potential target for gastric cancer therapy chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24388988 CDKN2B-AS1 ischemic stroke Regulation ANRIL may increase the risk of ischemic stroke through regulation of the CARD8 pathway chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 24385277 TC0101441 ovarian cancer Regulation TC0101441 contributes to E2-induced EOC cell migration/invasion N/A N/A N/A N/A Human N/A N/A 24380700 GAS5 non-small cell lung cancer Expression GAS5 could serve as a potential diagnostic marker for NSCLC and may be a novel therapeutic target in patients with NSCLC chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 24357161 MEG3 tongue squamous cell carcinoma Regulation It may play important antitumor effects in TSCC pathogenesis chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24343426 CBR3-AS1 esophageal squamous cell carcinoma Regulation "PlncRNA-1 plays an important role in ESCC cell proliferation.Overexpression of PlncRNA-1 is correlated with advanced tumor stage and lymph node metastasis, and may serve as a potential prognostic marker and therapeutic target for ESCC" chr21 36131767 36156308 - Human PlncRNA-1; PlncRNA1 NR_038894 24337686 UCA1 tongue squamous cell carcinoma Expression Expression of UCA1 lncRNA was enhanced in TSCCs and may play a role in tumor metastasis chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24332332 PRNCR1 colorectal cancer Locus SNPs in the lncRNA PRNCR1 may contribute to susceptibility to CRC chr8 127079874 127092595 + Human CARLo-3; PCAT8 NR_109833 24330491 MALAT1 non-small cell lung cancer Expression MALAT1 might be applicable as a complementary biomarker within a panel in order to improve the entire diagnostic performance chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24313945 LOC391533 pre-eclampsia Regulation "Misregulation of LOC391533, LOC284100, and CEACAMP8 might contribute to the mechanism underlying preeclampsia" N/A N/A N/A N/A Human N/A N/A 24312300 LOC284100 pre-eclampsia Regulation "Misregulation of LOC391533, LOC284100, and CEACAMP8 might contribute to the mechanism underlying preeclampsia" N/A N/A N/A N/A Human N/A N/A 24312300 CEACAMP8 pre-eclampsia Regulation "Misregulation of LOC391533, LOC284100, and CEACAMP8 might contribute to the mechanism underlying preeclampsia" chr19 43035869 43041248 - Human CEACAMP8 ENST00000413902 24312300 AK139328 reperfusion injury Regulation Silencing of long noncoding RNA AK139328 attenuates ischemia/reperfusion injury in mouse livers N/A N/A N/A N/A Mouse N/A N/A 24312245 DQ786243 Crohn's disease N/A DQ786243 can be related with severity of CD N/A N/A N/A N/A Human N/A N/A 24289115 HOTAIR endometrial cancer Expression HOTAIR is upregulated in endometrial carcinoma and correlates with poor prognosis chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24285342 NEAT1 intrauterine growth restriction Expression The increase in NEAT1 and its co-localization with PSPC1 suggests an increase in paraspeckles in IUGR villous trophoblasts chr11 65422798 65445540 + Human LINC00084; NCRNA00084; TncRNA; VINC NR_131012 24280234 OVAAL ovarian cancer Regulation "It is emerging as potent regulator of cell physiology, and recent studies highlight its role in tumor development" chr1 180558974 180566518 + Human LINC01131; OVAL NR_125716 24265805 HOTAIR breast cancer Expression HOTAIR is an independent prognostic marker of metastasis in estrogen receptor-positive primary breast cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24258260 HULC gastric cancer Regulation HULC may play an important role in the growth and tumorigenesis of human GC chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 24247585 MALAT1 colorectal cancer Regulation "The anti-tumor effects of resveratrol on CRC are through inhibiting Wnt/β-catenin signaling, thus the expression of its target genes such as c-Myc, MMP-7, as well as the expression of MALAT1" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 24244343 SPRY4-IT1 pre-eclampsia Regulation "SPRY4-IT1 is a novel lncRNA molecule, which might be associated with the pathogenesis of preeclampsia and might provide a new target for its early diagnosis and treatment." chr5 142317620 142318322 - Human SPRIGHTLY NR_131221 24223182 H19 bladder cancer Regulation H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24209571 PVT1 diabetic nephropathy Regulation "Role of microRNA 1207-5P and its host gene, the long non-coding RNA Pvt1, as mediators of extracellular matrix accumulation in the kidney: implications for diabetic nephropathy" chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 24204837 HOTAIR glioma Expression HOTAIR is an important long noncoding RNA that primarily serves as a prognostic factor for glioma patient survival chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24203894 PVT1 colorectal cancer Expression "PVT-1, which maps to 8q24, generates antiapoptotic activity in CRC, and abnormal expression of PVT-1 was a prognostic indicator for CRC patients" chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 24196785 CRNDE colorectal cancer Expression It may correlate with their upregulation in colorectal cancer chr16 54845189 54929189 - Human CRNDE ENST00000613942 24184209 TUC339 hepatocellular carcinoma Regulation TUC339 was functionally implicated in modulating tumor cell growth and adhesion N/A N/A N/A N/A Human N/A N/A 24167654 HOTAIR lung adenocarcinoma Regulation Upregulation of HOTAIR contributes to the cisplatin resistance of LAD cells chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24155936 HOTAIR esophageal squamous cell carcinoma Regulation Upregulation of the long non-coding RNA HOTAIR promotes esophageal squamous cell carcinoma metastasis and poor prognosis chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24151120 SMAD1-AS1 ventricular septal defects N/A It plays an important role in VSD chr4 145514578 145517194 - Human N/A NR_126371 24147006 RP11-473L15.2 ventricular septal defects N/A It plays an important role in VSD chr5 44388732 44413989 + Human FGF10-AS1 ENST00000502457 24147006 H19 osteosarcoma Regulation Aberrant Hh signaling in mature osteoblasts is responsible for the pathogenesis of osteoblastic osteosarcoma through Yap1 and H19 overexpression chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 24141783 XIST breast cancer Regulation The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression chrX 73820651 73852753 - Human DXS1089; DXS399E; LINC00001; NCRNA00001; SXI1; swd66 NR_001564 24141629 HOTAIR gastric cancer Regulation HOTAIR plays a pivotal role in the development of gastric cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24130837 HOTAIR esophageal squamous cell carcinoma Expression "HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24118380 HOTTIP hepatocellular carcinoma Expression Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. chr7 27200421 27207259 + Human HOXA-AS6; HOXA13-AS1; NCRNA00213 NR_037843 24114970 SOX2-OT esophageal squamous cell carcinoma Mutation A part for SOX2OT spliced variants in tumor initiation and progression as well as regulating pluripotent state of stem cells chr3 181056680 181742228 + Human NCRNA00043; SOX2OT NR_075089 24105929 HOTAIR non-small cell lung cancer Expression HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24103700 MEG3 non-small cell lung cancer Regulation MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24098911 DQ786227 lung cancer Locus LncRNA-DQ786227 acts as an oncogene in malignantly transformed BEAS-2B cells induced by benzo(a)pyrene N/A N/A N/A N/A Human N/A N/A 24084393 AC068718.1 post-traumatic stress disorder Regulation The non-coding RNA gene may play a crucial role in shaping the landscape of gene regulation with putative pathological effects that lead to phenotypic differences chr2 187712816 188384313 - Human LINC01090 ENST00000415357 24080187 CCAT2 breast cancer Regulation CCAT2 upregulates cell migration and downregulates chemosensitivity to 5'FU in a rs6983267-independent manner chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 24077681 SCHLAP1 prostate cancer Regulation SChLAP1 contributes to the development of lethal cancer at least in part by antagonizing the tumor-suppressive functions of the SWI/SNF complex chr2 180692104 180916939 + Human SCHLAP1 ENST00000629145 24076601 GAS5 bladder cancer Regulation Downregulated GAS5 promotes bladder cancer cell proliferation chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 24069260 UCA1 bladder cancer Regulation "Ets-2 regulates apoptosis process by regulating the expression of UCA1, moreover UCA1 may be involved in the activation of Akt signaling pathway by Ets-2 in bladder cancer cells" chr19 15828947 15836321 + Human CUDR; LINC00178; NCRNA00178; UCAT1; onco-lncRNA-36 NR_015379 24069250 TUG1 melanoma Regulation Down-regulation of long non-coding RNA TUG1 suppresses melanoma cell proliferation and induces apoptosis via up regulating microRNA-9 chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 24055035 GAS5 pancreatic cancer Regulation Downregulation of gas5 increases pancreatic cancer cell proliferation by regulating CDK6 chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 24026436 HOTAIR oesophageal squamous cell carcinoma Regulation HOTAIR-mediated gene regulation has a critical role in ESCC progression and is a novel epigenetic molecular target for treating ESCC patients chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 24022190 MEG3 gastric cancer Regulation Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 24006224 HNF1A-AS1 oesophageal adenocarcinoma Regulation Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells chr12 120969838 120972292 - Human C12orf27; NCRNA00262 NR_024345 24000294 SUMO1P3 gastric cancer Regulation Pseudogene-expressed lncRNA SUMO1P3 may be a potential biomarker in the diagnosis of gastric cancer chr1 160317403 160317706 + Human SUMO1P3 ENST00000439961 23996296 KCNQ1OT1 hepatocellular carcinoma Mutation "The STR polymorphism within KCNQ1OT1 contributes to hepatocarcinogenesis, possibly by affecting KCNQ1OT1 and CDKN1C expression through a structure-dependent mechanism" chr11 2608328 2699998 - Human KCNQ1-AS2; KCNQ10T1; Kncq1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012 NR_002728 23984860 GAS6-AS1 non-small cell lung cancer Expression Low expression of long noncoding RNA GAS6 AS1 predicts a poor prognosis in patients with NSCLC chr13 113815610 113842841 + Human N/A NR_044995 23979857 PRNCR1 prostate cancer Regulation PRNCR1 may play an important role in the progression of castration resistant prostate cancer through mediating the expression of AR chr8 127079874 127092595 + Human CARLo-3; PCAT8 NR_109833 23948400 H19 esophageal squamous cell carcinoma Regulation "H19 CBS6 methylation potentially represents a novel clinically relevant epigenetic marker to identify individuals at increased risk for the occurrence, progression and prognosis of ESCC" chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 23943562 HOTAIR prostate cancer Regulation Genistein inhibited PCa cell growth through down-regulation of oncogenic HOTAIR that is also targeted by tumor suppressor miR-34a chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23936419 T-ALL-R-LncR1 acute lymphoblastic leukemia Regulation A novel long non-coding RNA T-ALL-R-LncR1 knockdown and Par-4 cooperate to induce cellular apoptosis in T-cell acute lymphoblastic leukemia cells N/A N/A N/A N/A Human N/A N/A 23906015 HOTAIR gastric cancer Regulation It plays a role in gastric cancer progression chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23888369 lincRNA-uc003opf.1 esophageal squamous cell carcinoma Mutation Functional polymorphism rs11752942A>G in lincRNA uc003opf.1 exon might be a genetic modifier for the development of ESCC N/A N/A N/A N/A Human N/A N/A 23872665 HOTAIR melanoma Regulation "HOTAIR is associated with motility, invasion, and metastatic potential of metastatic melanoma" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23862139 HOTAIR gastric cancer Regulation Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial-mesenchymal transition in gastric cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23847441 MALAT1 prostate cancer Regulation MALAT-1 may be needed to maintain prostate tumorigenicity and it is involved in prostate cancer progression chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 23845456 NEAT1_2 amyotrophic lateral sclerosis Regulation "NEAT1_2 lncRNA may act as a scaffold of RNAs and RNA binding proteins in the nuclei of ALS motor neurons, thereby modulating the functions of ALS-associated RNA-binding proteins during the early phase of ALS" chr11 65423638 65423742 + Human NEAT1_2 ENST00000620525 23835137 CDKN2B-AS1 atherosclerosis N/A ANRIL is associated with atherosclerosis chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23813974 CDKN2B-AS1 periodontitis N/A ANRIL is associated with periodontitis chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23813974 CCAT2 colon cancer Regulation "CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer" chr8 127400399 127402150 + Human LINC00873; NCCP1 NR_109834 23796952 Kcna2 neuropathic pain Regulation Endogenous Kcna2 antisense RNA as a therapeutic target for the treatment of neuropathic pain. N/A N/A N/A N/A Human N/A N/A 23792947 MEG3 cervical cancer Regulation MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 23790166 HULC hepatocellular carcinoma Expression The expression of HULC in plasma can be used as a noninvasive promising novel biomarker for the diagnosis and/or prognosis of HCC chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 23762823 HOTAIR non-small cell lung cancer Regulation HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23743197 AK126698 non-small cell lung cancer Regulation "Knockdown lncRNA AK126698 not only greatly decreased NKD2 which can negatively regulate Wnt/β-catenin signaling but also increased the accumulation and nuclear translocation of β-catenin, and significantly depressed apoptosis rate induced by cisplatin in A549 cells" N/A N/A N/A N/A Human N/A N/A 23741487 MALAT1 prostate cancer Expression Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 derived miniRNA as a novel plasma-based biomarker for diagnosing prostate cancer chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 23726266 TUG1 osteosarcoma Regulation Down-regulation of long non-coding RNA TUG1 inhibits osteosarcoma cell proliferation and promotes apoptosis chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 23725133 GHSROS non-small cell lung cancer Expression "Engineered overexpression of GHSROS stimulated cell migration in the A549 and NCI H1299 non-small cell lung cancer cell lines, but suppressed cell migration in the Beas-2B normal lung-derived bronchoepithelial cell line" N/A N/A N/A N/A Human N/A N/A 23722988 HOTAIR esophageal squamous cell carcinoma Expression HOTAIR is a prognostic marker for esophageal squamous cell carcinoma progression and survival chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23717443 MALAT1 nasopharyngeal carcinoma Regulation "MALAT1 can enhance the proliferation, invasion, and metastasis of CNE-1 cells" chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 23688988 BLACAT1 bladder cancer Expression "Overexpressed linc-UBC1 physically associates with PRC2 complex, and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer" chr1 205434886 205456086 - Human LINC00912; linc-UBC1; onco-lncRNA-30 NR_103783 23688781 LOC285194 colorectal cancer Expression LOC285194 might be a novel prognostic indicator in colorectal cancer and may be a potential target for diagnosis and gene therapy N/A N/A N/A N/A Human N/A N/A 23680400 GAS5 prostate cancer Regulation GAS5 regulates apoptosis in prostate cancer cell lines chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 23676682 LUCAT1 lung cancer Regulation It may act downstream of NRF2 to regulate gene expression and mediate oxidative stress protection in airway epithelial cells chr5 91302986 91314402 - Human SCAL1 NR_103548 23672216 HOTAIR lung cancer Expression The expression of HOTAIR and Col-1 was concurrently up-regulated in human non-small cell lung cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23668363 HOXA-AS2 promyelocytic leukemia Regulation HOXA-AS2 is an apoptosis repressor in all trans retinoic acid treated NB4 promyelocytic leukemia cells chr7 27121919 27128760 + Human HOXA3as NR_122069 23649634 AC096655.1 gastric cancer Expression LncRNA AC096655.1-002 may be a potential biomarker in the diagnosis of gastric carcinoma N/A N/A N/A N/A Human N/A N/A 23645148 CTBP1-AS prostate cancer Regulation CTBP1-AS promotes prostate cancer chr4 1210120 1218591 + Human PCAT10 NR_104331 23644382 MIR7-3HG liver cancer Expression Reduced expression of uc002mbe.2 may be associated with liver carcinogenesis chr19 4769105 4772556 + Human C19orf30; Huh7; LINC00306; NCRNA00306; PGSF1; uc002mbe.2 NR_027148 23643933 PCAT1 colorectal cancer Expression Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer chr8 127013154 127021014 + Human PCA1; PCAT-1 NR_045262 23640607 MIAT schizophrenia Regulation Dysregulation of Gomafu leads to alternative splicing patterns that resemble those observed in SZ for the archetypal SZ-associated genes DISC1 and ERBB4 chr22 26657482 26676478 + Human C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT NR_033320 23628989 GAS5 renal cell carcinoma Regulation GAS5 functions as a tumor suppressor in renal cell carcinoma chr1 173863901 173867987 - Human NCRNA00030; SNHG2 NR_002578 23621190 Llme23 melanoma Locus Llme23 can function as an oncogenic RNA and directly associate the PSF-binding lncRNA with human melanoma N/A N/A N/A N/A Human N/A N/A 23618401 HOTAIR ovarian cancer Expression "It may play a role in ovarian cancer, and become a biomarker for malignant degree of ovarian cancer and may provide a novel therapeutic target for ovarian cancer" chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23600210 PTCSC3 thyroid cancer Regulation "A long non-coding RNA, PTCSC3, as a tumor suppressor and a target of miRNAs in thyroid cancer cells" chr14 36135710 36176651 - Human N/A NR_049735 23599737 CCAT1 colorectal cancer Regulation CCAT1 is up-regulated across the colon adenoma-carcinoma sequence chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 23594791 CK19 breast cancer Regulation It may play a role in tumorogenesis N/A N/A N/A N/A Human N/A N/A 23585313 PVT1 B-cell lymphoma Regulation Deletion or methylation of CDKN2A/2B and PVT1 rearrangement occur frequently in highly aggressive B-cell lymphomas harboring 8q24 abnormality chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 23547836 LINC00312 nasopharyngeal carcinoma Expression "LINC00312 could represent a potential biomarker for metastasis, progression and prognosis in NPC" chr3 8571782 8574668 + Human ERR-10; ERR10; LMCD1DN; LOH3CR2A; NAG-7; NAG7; NCRNA00312 NR_024065 23529758 PCGEM1 prostate cancer Mutation PCGEM1 polymorphisms may contribute to PCa risk in Chinese men chr2 192749845 192776899 + Human LINC00071; NCRNA00071; PCAT9 NR_002769 23459097 CCAT1 colorectal cancer Expression CCAT1 TO-PNA-MB is a powerful diagnostic tool for the specific identification of CRC chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 23416875 Xist hematologic cancer Regulation Xist RNA is a potent suppressor of hematologic cancer in mice chrX 103460373 103483233 - Mouse A430022B11; AI314753 NR_001570 23415223 CCDC26 glioma Regulation It plays an important role in glioma development chr8 129351694 129680239 - Human RAM NR_130917 23399484 H19 bladder cancer Regulation Upregulated H19 contributes to bladder cancer cell proliferation by regulating ID2 expression chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 23399020 HOTAIR breast cancer Regulation HOTAIR overexpression potentially contributes towards breast cancer progression chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23375982 H19 bladder cancer Regulation H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 23354591 AFAP1-AS1 esophageal adenocarcinoma Expression "Methylation of the long noncoding RNA AFAP1 AS1 is reduced in BE and EAC, and its expression inhibits cancer-related biologic functions of EAC cells" chr4 7754090 7778928 + Human AFAP1-AS; AFAP1AS NR_026892 23333711 CDKN2B-AS1 coronary artery disease Expression Complex regulatory variation affecting ANRIL and CDKN2B gene expression may contribute to increased risk for clinically apparent and subclinical coronary artery disease and aortic disease chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23315372 MEG3 meningioma Regulation MEG3 may have a significant role as a novel long noncoding RNA tumour suppressor in meningiomas chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 23307326 MEG3 bladder cancer Regulation Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer chr14 100826108 100861026 + Human FP504; GTL2; LINC00023; NCRNA00023; PRO0518; PRO2160; onco-lncRNA-83; prebp1 NR_046472 23295831 HOTAIR hepatocellular carcinoma Expression HOTAIR expression is associated with HCC progression chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23292722 HOTAIR nasopharyngeal carcinoma Regulation Dysregulation of HOTAIR might play an important role in NPC progression chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23281836 CDKN2B-AS1 myocardial infarction Expression It could be used as a useful genetic marker for the screening of MI chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23266621 MALAT1 lung cancer Regulation MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 23243023 H19 hepatocellular carcinoma Regulation "H19 contributes to carcinogenesis, including hepatocellular carcinoma" chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 23222811 MALAT1 urothelial cancer Regulation MALAT1 plays an oncogenic role in urothelial carcinoma of the bladder chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 23153939 CCAT1 gastric cancer Regulation "CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma" chr8 127207382 127219268 - Human CARLo-5; onco-lncRNA-40 NR_108049 23143645 HOTAIR laryngeal squamous cell carcinoma Regulation Long intergenic noncoding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23141928 HOTAIR breast cancer Expression Association of large noncoding RNA HOTAIR expression and its downstream intergenic CpG island methylation with survival in breast cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 23124417 CDKN2B-AS1 primary open-angle glaucoma N/A CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23111177 CDKN2B-AS1 neurofibromatosis N/A It plays an important role in neurofibroma chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23101500 CDKN2B-AS1 coronary artery disease Expression ANRIL expression may involve in the mechanisms of chromosome 9p21 on CAD development chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 23091611 LINC00237 MOMO syndrome Regulation LINC00237 could play a role in the pathogenesis of this syndrome and could provide new insights into hyperphagia related obesity and intellectual disability chr20 21087629 21106341 - Human NCRNA00237 NR_147212 23034868 RERT hepatocellular carcinoma Regulation "Rs10680577 contributes to hepatocarcinogenesis, possibly by affectingRERT-lncRNA structure and subsequently EGLN2 expression, making it a promising biomarker for early diagnosis of HCC" N/A N/A N/A N/A Human N/A N/A 23026137 TUG1 bladder urothelial carcinoma Expression TUG1 may have potential roles as a biomarker and/or a therapeutic target in bladder urothelial carcinoma chr22 30969211 30979395 + Human LINC00080; NCRNA00080; TI-227H NR_002323 22961206 LINC00887 renal clear cell carcinoma Regulation It may exert a partial or key role in tumor development chr3 194301199 194312804 - Human HEIRCC NR_024480 22879955 X91348 renal clear cell carcinoma Regulation It may exert a partial or key role in tumor development N/A N/A N/A N/A Human N/A N/A 22879955 BC029135 renal clear cell carcinoma Regulation It may exert a partial or key role in tumor development N/A N/A N/A N/A Human N/A N/A 22879955 LOC389332 renal clear cell carcinoma Regulation It may exert a partial or key role in tumor development N/A N/A N/A N/A Human N/A N/A 22879955 PVT1 multiple myeloma Regulation PVT1 rearrangements may represent a novel molecular paradigm underlying the pathology of 8q24 rearrangement-positive multiple myeloma chr8 127794533 128101253 + Human LINC00079; MYC; NCRNA00079; onco-lncRNA-100 NR_003367 22869583 H19 pre-eclampsia Expression Aberrantly lowered expression of H19 in placenta may participate in the excessive proliferation of trophoblast cells observed in early-onset severe preeclampsia chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 22832245 H19 gastric cancer Regulation Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 22776265 MALAT1 bladder cancer Regulation Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition chr11 65497679 65504494 + Human HCN; LINC00047; NCRNA00047; NEAT2; PRO2853 NR_002819 22722759 MVIH hepatocellular carcinoma Regulation Deregulation of lncRNA MVIH is a predictor for poor RFS of HCC patients after hepatectomy and could be utilized as a potential target for new adjuvant therapies against active angiogenesis N/A N/A N/A N/A Human N/A N/A 22706893 HULC hepatocellular carcinoma Regulation Up-regulated HULC by HBx promotes proliferation of hepatoma cells through suppressing p18 chr6 8652209 8653846 + Human HCCAT1; LINC00078; NCRNA00078 NR_004855 22685290 HOTAIR pancreatic cancer Regulation HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer chr12 53962308 53974956 - Human HOXAS; HOXC-AS4; HOXC11-AS1; NCRNA00072 NR_003716 22614017 PTCSC3 papillary thyroid carcinoma Regulation Long intergenic noncoding RNA gene (PTCSC3) that has the characteristics of a tumor suppressor chr14 36135710 36176651 - Human N/A NR_049735 22586128 BANCR melanoma Regulation BANCR knockdown reduced melanoma cell migration chr9 69296681 69307056 - Human LINC00586 NR_047671 22581800 CDKN2B-AS1 neurofibromatosis N/A It plays an important role in neurofibromatosis chr9 21994791 22121097 + Human ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; PCAT12; p15AS NR_047538 22578354 H19 Beckwith-Wiedemann syndrome Locus Gain of methylation (GOM) at the H19 differentially methylated region (H19-DMR) is one of several causative alterations in Beckwith-Wiedemann syndrome chr11 1995176 2001466 - Human ASM; ASM1; BWS; D11S813E; LINC00008; NCRNA00008; WT2 NR_131223 22577095