category	mir	disease	pmid	description
genetics_GWAS	hsa-mir-142	Leukemia	15737576	Some human miRNAs are linked to leukemias: the miR-15a/miR-16 locus is frequently deleted or down-regulated in patients with B-cell chronic lymphocytic leukemia and miR-142 is at a translocation site found in a case of aggressive B-cell leukemia.
genetics_GWAS	hsa-mir-189	Tourette Syndrome	16224024	we identified a frameshift mutation and two independent occurrences of the identical variant in the binding site for microRNA hsa-miR-189
genetics_GWAS	hsa-mir-16-1	"Leukemia, Lymphocytic, Chronic, B-Cell"	16251535	mutation
genetics_GWAS	hsa-mir-187	"Leukemia, Lymphocytic, Chronic, B-Cell"	16251535	mutation
genetics_GWAS	hsa-mir-206	"Leukemia, Lymphocytic, Chronic, B-Cell"	16251535	mutation
genetics_GWAS	hsa-mir-27b	"Leukemia, Lymphocytic, Chronic, B-Cell"	16251535	mutation
genetics_GWAS	hsa-mir-29b-1	"Leukemia, Lymphocytic, Chronic, B-Cell"	16251535	mutation
genetics_GWAS	hsa-mir-103a-2	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-103a-2	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-103a-2	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-106b	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-106b	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-106b	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-1-1	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-1-1	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-1-1	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-133a-2	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-133a-2	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-133a-2	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-135b	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-135b	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-135b	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-151a	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-151a	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-151a	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-153-2	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-153-2	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-153-2	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-17	Breast Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-17	Melanoma	16754881	copy number loss
genetics_GWAS	hsa-mir-17	Ovarian Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-18a	Breast Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-18a	Melanoma	16754881	copy number loss
genetics_GWAS	hsa-mir-18a	Ovarian Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-194-1	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-194-1	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-194-1	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-199a-2	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-199a-2	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-199a-2	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-19a	Breast Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-19a	Melanoma	16754881	copy number loss
genetics_GWAS	hsa-mir-19a	Ovarian Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-19b-1	Breast Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-19b-1	Melanoma	16754881	copy number loss
genetics_GWAS	hsa-mir-19b-1	Ovarian Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-200a	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-200a	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-200a	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-200b	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-200b	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-200b	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-20a	Breast Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-20a	Melanoma	16754881	copy number loss
genetics_GWAS	hsa-mir-20a	Ovarian Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-214	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-214	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-214	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-215	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-215	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-215	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-218-1	Breast Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-218-1	Melanoma	16754881	copy number loss
genetics_GWAS	hsa-mir-218-1	Ovarian Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-219-1	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-219-1	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-219-1	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-25	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-25	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-25	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-296	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-296	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-296	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-302a	Breast Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-302a	Melanoma	16754881	copy number loss
genetics_GWAS	hsa-mir-302a	Ovarian Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-302b	Breast Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-302b	Melanoma	16754881	copy number loss
genetics_GWAS	hsa-mir-302b	Ovarian Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-302c	Breast Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-302c	Melanoma	16754881	copy number loss
genetics_GWAS	hsa-mir-302c	Ovarian Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-302d	Breast Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-302d	Melanoma	16754881	copy number loss
genetics_GWAS	hsa-mir-302d	Ovarian Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-30b	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-30b	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-30b	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-30d	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-30d	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-30d	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-320a	Breast Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-320a	Melanoma	16754881	copy number loss
genetics_GWAS	hsa-mir-320a	Ovarian Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-338	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-338	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-338	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-339	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-339	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-339	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-367	Breast Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-367	Melanoma	16754881	copy number loss
genetics_GWAS	hsa-mir-367	Ovarian Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-383	Breast Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-383	Melanoma	16754881	copy number loss
genetics_GWAS	hsa-mir-383	Ovarian Neoplasms	16754881	copy number loss
genetics_GWAS	hsa-mir-429	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-429	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-429	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-488	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-488	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-488	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-9-1	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-9-1	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-9-1	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-93	Breast Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-93	Melanoma	16754881	copy number gain
genetics_GWAS	hsa-mir-93	Ovarian Neoplasms	16754881	copy number gain
genetics_GWAS	hsa-mir-1	Vascular Hypertrophy	17381315	we have identified an A-to-G transition in the 3'UTR of the GDF8 gene that reveals an illegitimate target site for microRNAs miR-1 and miR-206 that are highly expressed in skeletal muscle.
genetics_GWAS	hsa-mir-206	Vascular Hypertrophy	17381315	we have identified an A-to-G transition in the 3'UTR of the GDF8 gene that reveals an illegitimate target site for microRNAs miR-1 and miR-206 that are highly expressed in skeletal muscle.
genetics_GWAS	hsa-mir-146a	Thyroid Neoplasms	17468766	"somatic mutations altering binding sites for miR-221, miR-222 and miR-146 have been observed in the 3'UTR of the KIT oncogene in papillary thyroid carcinoma."
genetics_GWAS	hsa-mir-146b	Thyroid Neoplasms	17468766	"somatic mutations altering binding sites for miR-221, miR-222 and miR-146 have been observed in the 3'UTR of the KIT oncogene in papillary thyroid carcinoma."
genetics_GWAS	hsa-mir-221	Thyroid Neoplasms	17468766	"somatic mutations altering binding sites for miR-221, miR-222 and miR-146 have been observed in the 3'UTR of the KIT oncogene in papillary thyroid carcinoma."
genetics_GWAS	hsa-mir-222	Thyroid Neoplasms	17468766	"somatic mutations altering binding sites for miR-221, miR-222 and miR-146 have been observed in the 3'UTR of the KIT oncogene in papillary thyroid carcinoma."
genetics_GWAS	hsa-mir-198	Schizophrenia	17849003	SNP (rs1700) disease susceptibility
genetics_GWAS	hsa-mir-206	Schizophrenia	17849003	SNP (rs17578796) disease susceptibility
genetics_GWAS	hsa-mir-146a	Thyroid Neoplasms	18474871	"Thus, our data suggest that a common polymorphism in pre-miR-146a affects the miR expression, contributes to the genetic predisposition to PTC, and plays a role in the tumorigenesis through somatic mutation."
genetics_GWAS	hsa-mir-196a-2	Lung Neoplasms	18521189	"Therefore, the rs11614913 SNP in hsa-mir-196a2 may be a prognostic biomarker for NSCLC."
genetics_GWAS	hsa-mir-510	Irritable Bowel Syndrome	18614545	First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor type 3E gene with diarrhea predominant irritable bowel syndrome.
genetics_GWAS	hsa-mir-146a	Breast Neoplasms	18634034	miR-146: rs2910164 were associated with increased risk of breast cancer in Chinese women
genetics_GWAS	hsa-mir-146b	Breast Neoplasms	18634034	miR-146: rs2910164 were associated with increased risk of breast cancer in Chinese women
genetics_GWAS	hsa-mir-149	Breast Neoplasms	18634034	miR-149: rs2292832 were associated with increased risk of breast cancer in Chinese women
genetics_GWAS	hsa-mir-196a-2	Breast Neoplasms	18634034	miR-196a-2: rs11614913 were associated with increased risk of breast cancer in Chinese women
genetics_GWAS	hsa-mir-499a	Breast Neoplasms	18634034	miR-499: rs3746444 were associated with increased risk of breast cancer in Chinese women
genetics_GWAS	hsa-mir-146a	Breast Neoplasms	18660546	miR-146a: A functional polymorphism (rs2910164) in the miR-146a gene and age of familial breast/ovarian cancer diagnosis
genetics_GWAS	hsa-mir-146a	Ovarian Neoplasms	18660546	miR-146a: A functional polymorphism (rs2910164) in the miR-146a gene and age of familial breast/ovarian cancer diagnosis
genetics_GWAS	hsa-mir-146a	"Carcinoma, Hepatocellular"	18711148	miR-146a: A functional polymorphism (rs2910164) in the miR-146a gene is associated with the risk for hepatocellular carcinoma
genetics_GWAS	hsa-mir-659	Dementia	18723524	miR-659: Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia
genetics_GWAS	hsa-let-7a	"Carcinoma, Lung, Non-Small-Cell"	18922928	A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk.
genetics_GWAS	hsa-let-7a-1	"Carcinoma, Lung, Non-Small-Cell"	18922928	A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk.
genetics_GWAS	hsa-let-7a-1	Lung Neoplasms	18922928	let-7a: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
genetics_GWAS	hsa-let-7a-2	"Carcinoma, Lung, Non-Small-Cell"	18922928	A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk.
genetics_GWAS	hsa-let-7a-2	Lung Neoplasms	18922928	let-7a: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
genetics_GWAS	hsa-let-7a-3	"Carcinoma, Lung, Non-Small-Cell"	18922928	A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk.
genetics_GWAS	hsa-let-7a-3	Lung Neoplasms	18922928	let-7a: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
genetics_GWAS	hsa-let-7b	"Carcinoma, Lung, Non-Small-Cell"	18922928	A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk.
genetics_GWAS	hsa-let-7b	Lung Neoplasms	18922928	let-7b: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
genetics_GWAS	hsa-let-7c	Lung Neoplasms	18922928	let-7c: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
genetics_GWAS	hsa-let-7d	"Carcinoma, Lung, Non-Small-Cell"	18922928	A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk.
genetics_GWAS	hsa-let-7d	Lung Neoplasms	18922928	let-7d: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
genetics_GWAS	hsa-let-7e	Lung Neoplasms	18922928	let-7e: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
genetics_GWAS	hsa-let-7f-1	Lung Neoplasms	18922928	let-7f: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
genetics_GWAS	hsa-let-7f-2	Lung Neoplasms	18922928	let-7f: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
genetics_GWAS	hsa-let-7g	"Carcinoma, Lung, Non-Small-Cell"	18922928	A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk.
genetics_GWAS	hsa-let-7g	Lung Neoplasms	18922928	let-7g: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
genetics_GWAS	hsa-let-7i	Lung Neoplasms	18922928	let-7i: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk
genetics_GWAS	hsa-mir-17	Breast Neoplasms	19048628	miR-17: mutations
genetics_GWAS	hsa-mir-30c-1	Breast Neoplasms	19048628	miR-30c-1: mutations
genetics_GWAS	hsa-mir-122	Hypertension	19067360	a polymorphism of the 3'UTR of the SLC7A1 gene affects the binding with miR-122
genetics_GWAS	hsa-mir-146a	Thyroid Neoplasms	19164563	miR-146a: SNP rs2910164 contribute to thyroid cancer
genetics_GWAS	hsa-mir-96	Sensorineural Hearing Loss	19363478	miR-96: An ENU-induced mutation
genetics_GWAS	hsa-mir-96	Sensorineural Hearing Loss	19363479	miR-96: Mutations in the seed region
genetics_GWAS	hsa-mir-128	Anxiety Disorders	19370765	Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders.
genetics_GWAS	hsa-mir-148a	Anxiety Disorders	19370765	Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders.
genetics_GWAS	hsa-mir-148b	Anxiety Disorders	19370765	Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders.
genetics_GWAS	hsa-mir-152	Anxiety Disorders	19370765	Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders.
genetics_GWAS	hsa-mir-485	Anxiety Disorders	19370765	Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders.
genetics_GWAS	hsa-mir-509	Anxiety Disorders	19370765	Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders.
genetics_GWAS	hsa-mir-765	Anxiety Disorders	19370765	Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders.
genetics_GWAS	hsa-mir-125b	Breast Neoplasms	19738052	A risk variant in an miR-125b binding site in BMPR1B is associated with breast cancer pathogenesis.
genetics_GWAS	hsa-mir-196a-2	Gastric Neoplasms	19834808	miR-196a-2:Association of microRNA-196a-2 gene polymorphism with gastric cancer risk
genetics_GWAS	hsa-mir-499	Breast Neoplasms	19847796	"Recently, the SNPs rs11614913 in hsa-mir-196a2 and rs3746444 in hsa-mir-499 were reported to be associated with increased breast cancer risk, and the SNP rs2910164 in hsa-mir-146a was shown to have an effect on age of breast cancer diagnosis."
genetics_GWAS	hsa-mir-146a	Prostate Neoplasms	19902466	"The natural genetic variation in pre-miR-146a affects the amount of mature miR-146a, contributes to the genetic predisposition to CaP."
genetics_GWAS	hsa-mir-15a	Multiple Myeloma	20031211	miR-15a:Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma
genetics_GWAS	hsa-mir-16-1	Multiple Myeloma	20031211	miR-16:Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma
genetics_GWAS	hsa-mir-16-2	Multiple Myeloma	20031211	miR-16:Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma
genetics_GWAS	hsa-mir-492	Colorectal Carcinoma	20044760	"mir-492:In a univariate analysis, the progression-free survival of the patients with the combined mir492 C/G and G/G genotype was significantly worse than that of the patients with the mir492 C/C genotype (rs2289030) (P value = 0.0426)"
genetics_GWAS	hsa-mir-218-1	Urinary Bladder Cancer	20163849	miR-218:Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer
genetics_GWAS	hsa-mir-218-2	Urinary Bladder Cancer	20163849	miR-218:Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer
genetics_GWAS	hsa-mir-191	Ovarian Neoplasms	20167074	Novel genetic variants in miR-191 gene and familial ovarian cancer
genetics_GWAS	hsa-mir-196a-2	"Carcinoma, Hepatocellular"	20188135	miR-196a2:MIR196A2 polymorphism was associated with susceptibility to HBV-related HCC in a maleChinese population.
genetics_GWAS	hsa-mir-196a-1	Glioma	20229273	A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population
genetics_GWAS	hsa-mir-196a-2	Glioma	20229273	A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population
genetics_GWAS	hsa-mir-128-2	"Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic"	20237425	A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 acute lymphocytic leukemia cells.
genetics_GWAS	hsa-mir-30e	Schizophrenia	20347265	miR-30e:mir-30e ss178077483 plays a role in schizophrenia susceptibility
genetics_GWAS	hsa-mir-204	Neoplasms [unspecific]	20439436	"miR-204:hsa-miR-30 and hsa-miR-204, were found to be physically altered at the DNA copy number level as well"
genetics_GWAS	hsa-mir-20a	Neoplasms [unspecific]	20439436	mir-20a:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted
genetics_GWAS	hsa-mir-30a	Neoplasms [unspecific]	20439436	"miR-30:hsa-miR-103/106 were downgraded in cancer, whereas hsa-miR-30 became most prominent"
genetics_GWAS	hsa-mir-125b-1	"Leukemia, Biphenotypic, Acute"	20485370	miR-125b-1:A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia
genetics_GWAS	hsa-mir-196a-2	"Cardiomyopathy, Dilated"	20488170	mir-196a2:Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy
genetics_GWAS	hsa-mir-499a	"Cardiomyopathy, Dilated"	20488170	mir-499:Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy
genetics_GWAS	hsa-mir-499	"Squamous Cell Carcinoma, Head and Neck"	20549817	"Of the 4 SNPs that were studied, the hsa-mir-499 AG and GG genotypes were associated with a reduced risk of SCCHN"
genetics_GWAS	hsa-mir-30e	Schizophrenia	20579744	Our previous study revealed a strong association between the polymorphism ss178077483 in the miRNA-30e precursor (pre-miR-30e) and the risk of SCZ.
genetics_GWAS	hsa-mir-126	"Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic"	20621067	miR-126:Alteration of processing induced by a single nucleotide polymorphism in pri-miR-126
genetics_GWAS	hsa-mir-146a	Gastrointestinal Neoplasms	20653068	Pre-miR-146a C/G polymorphism might be associated with an elevatedrisk of gastric cancer in Chinese population.
genetics_GWAS	hsa-mir-27a	Gastric Neoplasms	20666778	mir-27a:mir-27a genetic variant contributes to gastric cancer susceptibility
genetics_GWAS	hsa-mir-146a	Gastrointestinal Neoplasms	20721625	This study revealed the combined effect of miR-146a rs2910164 G/G and TLR4 +3725 C allele on the increased risk of severe gastric atrophy among the H. pylori-infected Japanese subjects.
genetics_GWAS	hsa-mir-155	Hypertension	20966899	"The interplay between miR-155 expression, +1166C polymorphism, and AT1R protein expression may have a role in the regulation of blood pressure."
genetics_GWAS	hsa-mir-146a	Gastrointestinal Neoplasms	21073609	The rs2910164 (G>C) SNP in the miR-146a is associated with susceptibility to GC.
genetics_GWAS	hsa-mir-221	Melanoma	21119596	This KIT variant results in a mismatch in the seed region of a miR-221 complementary site and reporter data suggests that this mismatch can result in increased expression ofthe KIT oncogene.
genetics_GWAS	hsa-mir-491	Colorectal Carcinoma	21128281	deleted
genetics_GWAS	hsa-mir-646	Colorectal Carcinoma	21128281	deleted
genetics_GWAS	hsa-mir-17	Breast Neoplasms	21140207	SNP (rs3739008) located at 3'UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-)17-5p and miR-519e to the 3'UTR of NPAS2
genetics_GWAS	hsa-mir-519e	Breast Neoplasms	21140207	SNP (rs3739008) located at 3'UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-)17-5p and miR-519e to the 3'UTR of NPAS2
genetics_GWAS	hsa-mir-569	Systemic Lupus Erythematosus	21162035	Association of a functional polymorphism in the 3' untranslated region of SPI1 with systemic lupus erythematosus.
genetics_GWAS	hsa-mir-196a-2	Colorectal Carcinoma	21241442	A variant ( rs11614913 ) in microRNA-196a2 is not associated with susceptibility to and progression of colorectal cancer in Chinese.
genetics_GWAS	hsa-mir-196a-1	Crohn Disease	21278745	The common exonic synonymous SNP (c.313C>T) in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease.
genetics_GWAS	hsa-mir-196a-2	Crohn Disease	21278745	The common exonic synonymous SNP (c.313C>T) in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease.
genetics_GWAS	hsa-mir-196b	Crohn Disease	21278745	The common exonic synonymous SNP (c.313C>T) in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease.
genetics_GWAS	hsa-mir-124-1	Breast Neoplasms	21318219	Genetic variants (SNP rs1042538 A/T) at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer.
genetics_GWAS	hsa-mir-124-2	Breast Neoplasms	21318219	Genetic variants (SNP rs1042538 A/T) at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer.
genetics_GWAS	hsa-mir-124-3	Breast Neoplasms	21318219	Genetic variants (SNP rs1042538 A/T) at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer.
genetics_GWAS	hsa-mir-146a	Esophageal Neoplasms	21319225	SNP (rs2910164 G/C): Significantly increased CSCC risks were found to be associated with G allele of rs2910164
genetics_GWAS	hsa-mir-146a	"Squamous Cell Carcinoma, Cerevial"	21319225	SNP (rs2910164 G/C): Significantly increased CSCC risks were found to be associated with G allele of rs2910164
genetics_GWAS	hsa-mir-499a	Esophageal Neoplasms	21319225	SNP (rs3746444 A/G): Significantly increased CSCC risks were found to be associated with G allele of rs3746444
genetics_GWAS	hsa-mir-499a	"Squamous Cell Carcinoma, Cerevial"	21319225	SNP (rs3746444 A/G): Significantly increased CSCC risks were found to be associated with G allele of rs3746444
genetics_GWAS	hsa-mir-196a-2	Urinary Bladder Cancer	21345130	"Our results showed that the heterozygous genotype of rs11614913 (hsa-mir-196a2 C>T rs11614913) was higher in cases than controls but the results were marginally significant (p=0.055; odds ratio, 1.44)."
genetics_GWAS	hsa-mir-196b	Urinary Bladder Cancer	21345130	"Our results showed that the heterozygous genotype of rs11614913 (hsa-mir-196a2 C>T rs11614913) was higher in cases than controls but the results were marginally significant (p=0.055; odds ratio, 1.44)."
genetics_GWAS	hsa-mir-569	Systemic Lupus Erythematosus	21360505	rs1057233 alters a target sequence for microRNA hsa-miR-569 (miR-569).
genetics_GWAS	hsa-mir-328	Myopia	21421876	"SNPs rs644242 and rs662702 had marginal significance (p=0.063) and further analyses showed that these SNPs were associated with extreme myopia. The OR for extreme myopia was 2.1 (empirical p=0.007) for the CC genotype at SNP rs662702 at 3' UTR. The functional assay for SNP rs662702 demonstrated that the C allele had a significantly lower expression level than the T allele (P=0.0001). SNP rs662702 was predicted to be located in the microRNA-328 binding site, which may explain the differential allelic effect on gene expression."
genetics_GWAS	hsa-let-7a-1	Ovarian Neoplasms	21482675	"rs12194974 (G>A), a SNP in a putative transcription factor binding site in the LIN28B promoter region (summary OR=0.90, 95% CI: 0.82-0.98; P=0.015). LIN28B LIN28B over-expression in epithelial ovarian cancer (EOC) contributes to tumorigenesis by repressing tumor suppressor let-7 expression."
genetics_GWAS	hsa-let-7a-2	Ovarian Neoplasms	21482675	"rs12194974 (G>A), a SNP in a putative transcription factor binding site in the LIN28B promoter region (summary OR=0.90, 95% CI: 0.82-0.98; P=0.015). LIN28B LIN28B over-expression in epithelial ovarian cancer (EOC) contributes to tumorigenesis by repressing tumor suppressor let-7 expression."
genetics_GWAS	hsa-let-7a-3	Ovarian Neoplasms	21482675	"rs12194974 (G>A), a SNP in a putative transcription factor binding site in the LIN28B promoter region (summary OR=0.90, 95% CI: 0.82-0.98; P=0.015). LIN28B LIN28B over-expression in epithelial ovarian cancer (EOC) contributes to tumorigenesis by repressing tumor suppressor let-7 expression."
genetics_GWAS	hsa-mir-196a-2	Breast Neoplasms	21483822	"rs11614913 polymorphism:Overall, individuals with the TC/CC genotypes were associated with higher cancer risk than those with the TT genotype (OR=1.18, 95% CI=1.03-1.34, P<0.001 for heterogeneity test). In the stratified analyses, we observed that the CC genotype might modulate breast cancer risk (OR=1.11, 95%CI=1.01-1.23, P(heterogeneity)=0.210) and lung cancer risk (OR=1.25, 95%CI=1.06-1.46, P(heterogeneity)=0.958), comparing with the TC/TT genotype. Moreover, a significantly increased risk was found among Asian populations in a dominant model (TC/CC versus TT, OR=1.24, 95% CI=1.07-1.43, P(heterogeneity)=0.006)."
genetics_GWAS	hsa-mir-196a-2	Lung Neoplasms	21483822	"rs11614913 polymorphism:Overall, individuals with the TC/CC genotypes were associated with higher cancer risk than those with the TT genotype (OR=1.18, 95% CI=1.03-1.34, P<0.001 for heterogeneity test). In the stratified analyses, we observed that the CC genotype might modulate breast cancer risk (OR=1.11, 95%CI=1.01-1.23, P(heterogeneity)=0.210) and lung cancer risk (OR=1.25, 95%CI=1.06-1.46, P(heterogeneity)=0.958), comparing with the TC/TT genotype. Moreover, a significantly increased risk was found among Asian populations in a dominant model (TC/CC versus TT, OR=1.24, 95% CI=1.07-1.43, P(heterogeneity)=0.006)."
genetics_GWAS	hsa-mir-146a	"Tuberculosis, Pulmonary"	21524676	"A polymorphism (rs2910164 G>C, in miR-146a) indicated an association with PTB risk in both Tibetan (p = 0.031) and Han (p = 0.000) populations. However, the role of the G allele of rs2910164, like the C allele in rs3746444, differed in the Tibetan (OR = 1.509, p < 0.05) and Han (OR = 0.575, p < 0.05) groups."
genetics_GWAS	hsa-mir-499a	"Tuberculosis, Pulmonary"	21524676	"There was no association between rs3746444 (in hsa-mir-499) and PTB risk (p = 0.118) in the Han population, but subjects carrying the C allele exhibited decreased PTB risk (odds ratio [OR] = 0.403 [95% confidence interval (95% CI) 0.278-0.583]). There was an association between rs3746444 and PTB in the Tibetan population, and individuals carrying the C allele exhibited increased PTB risk (OR = 1.870 [95% CI 1.218-2.871])."
genetics_GWAS	hsa-mir-146a	Urinary Bladder Cancer	21529907	Polymorphism (rs2910164) of the pre-miR-146a is associated with risk of cervical cancer in a Chinese population. The subjects carrying GG homozygote had a 1.496-foldincreased risk than those carrying CG/CC genotypes. The carriers of GG genotype had obviously more reduced miR-146a expression level compared with the carriers of CC genotype.
genetics_GWAS	hsa-mir-137	Melanoma	21543894	miR-137 under expression was significantly associated with melanomas with the KRAS-variant.
genetics_GWAS	hsa-mir-125b-1	Prostate Neoplasms	21556765	rs1434536 in the 3'UTR of BMPR1B gene affects the binding ability of miR-125b to BMPR1B mRNA and contributes to the genetic hspredisposition to localized prostate cancer and patients aged >70years.
genetics_GWAS	hsa-mir-125b-2	Prostate Neoplasms	21556765	rs1434536 in the 3'UTR of BMPR1B gene affects the binding ability of miR-125b to BMPR1B mRNA and contributes to the genetic hspredisposition to localized prostate cancer and patients aged >70years.
genetics_GWAS	hsa-mir-637	Hypertension	21558123	A common genetic variant (rs938671) in the 3'-UTR of Vacuolar H+-ATPase ATP6V0A1 creates a micro-RNA (hsa-miR-637) motif to alter Chromogranin A (CHGA) processing and hypertension risk.
genetics_GWAS	hsa-mir-519a-1	Gout	21558165	There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520.
genetics_GWAS	hsa-mir-519a-2	Gout	21558165	There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520.
genetics_GWAS	hsa-mir-519b	Gout	21558165	There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520.
genetics_GWAS	hsa-mir-519c	Gout	21558165	There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520.
genetics_GWAS	hsa-mir-519d	Gout	21558165	There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520.
genetics_GWAS	hsa-mir-519e	Gout	21558165	There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520.
genetics_GWAS	hsa-mir-520a	Gout	21558165	There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520.
genetics_GWAS	hsa-mir-520b	Gout	21558165	There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520.
genetics_GWAS	hsa-mir-520d	Gout	21558165	There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520.
genetics_GWAS	hsa-mir-520e	Gout	21558165	There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520.
genetics_GWAS	hsa-mir-520f	Gout	21558165	There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520.
genetics_GWAS	hsa-mir-520g	Gout	21558165	There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520.
genetics_GWAS	hsa-mir-520h	Gout	21558165	There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520.
genetics_GWAS	hsa-mir-196a-2	Chronic Obstructive Pulmonary Disease	21565178	"The TT genotype and T allele of miR-196a2 rs11614913 were significantly associated with a decreased risk for COPD (Chronic obstructive pulmonary disease), compared with the CC genotype and C allele. Similarly, the GG genotype and G allele of miR-499 rs3746444 were associated with a decreased risk for COPD, compared with the AA genotype and A allele."
genetics_GWAS	hsa-mir-499a	Chronic Obstructive Pulmonary Disease	21565178	"The TT genotype and T allele of miR-196a2 rs11614913 were significantly associated with a decreased risk for COPD (Chronic obstructive pulmonary disease), compared with the CC genotype and C allele. Similarly, the GG genotype and G allele of miR-499 rs3746444 were associated with a decreased risk for COPD, compared with the AA genotype and A allele."
genetics_GWAS	hsa-mir-196a-2	Colorectal Carcinoma	21565628	A Functional Variant in MicroRNA-196a2 (rs11614913 SNP) Is Associated with Susceptibility of Colorectal Cancer in a Chinese Population.
genetics_GWAS	hsa-mir-1302-1	Male Infertility	21601192	"Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro."
genetics_GWAS	hsa-mir-1302-2	Male Infertility	21601192	"Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro."
genetics_GWAS	hsa-mir-1302-3	Male Infertility	21601192	"Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro."
genetics_GWAS	hsa-mir-1302-4	Male Infertility	21601192	"Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro."
genetics_GWAS	hsa-mir-1302-5	Male Infertility	21601192	"Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro."
genetics_GWAS	hsa-mir-1302-6	Male Infertility	21601192	"Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro."
genetics_GWAS	hsa-mir-1302-7	Male Infertility	21601192	"Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro."
genetics_GWAS	hsa-mir-1302-8	Male Infertility	21601192	"Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro."
genetics_GWAS	hsa-mir-196a-2	Hepatitis C Virus Infection	21604580	SNP rs11614913 on miR196a-2 gene is associated with the antiviral therapy efficacy of hepatitis C patients.The TT genotype or T alleles be associated with the SVR while the CC genotype or C allele could be related to the NVR or recurrence.
genetics_GWAS	hsa-mir-196a-2	"Carcinoma, Lung, Non-Small-Cell"	21617338	MicroRNA196a2 rs11614913 Genotypes are associated with the Risk of Non-Small Cell Lung Cancer in Korean Population.
genetics_GWAS	hsa-mir-146a	Gastric Neoplasms	21632853	"miR-146a levels in cancer tissues were significantly lower than those in the corresponding noncancerous tissue. Lower levels of miR-146a were associated with lymph node metastasis and venous invasion. Moreover, a lower level of miR-146a was an independent prognostic factor for overall survival.Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells. In addition, G/C SNP within the pre-miR-146a seed sequence significantly reduced miR-146a levels in the GG genotype compared with the CC genotype."
genetics_GWAS	hsa-mir-492	Psoriasis	21655935	"The rs8259 T allele was associated with significantly decreased psoriasis susceptibility (OR=0.758, 95% CI 0.638-0.901, p=0.002) compared to A allele. the rs8259 polymorphism was located in a seed region for miR-492 binding."
genetics_GWAS	hsa-mir-1827	"Carcinoma, Lung, Small-Cell"	21676885	"Genetic Variation in an miRNA-1827 Binding Site in MYCL1 Alters Susceptibility to Small-Cell Lung Cancer. The rs3134615T allele was associated with a significantly increased risk of SCLC, with the OR for carrying the GT or TT genotype being 2.08 (95% confidence interval, 1.39-3.21; P = 0.0004) compared with the GG genotype."
genetics_GWAS	hsa-mir-146a	Systemic Lupus Erythematosus	21738483	A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus.
genetics_GWAS	hsa-mir-146a	Glioblastoma	21744077	"A functional polymorphism in the pre-miR-146a gene is associated with risk and prognosis in adult glioma. An increased glioma risk was observed among rs2910164 minor allele (C) carriers (per allele OR (95%CI)=1.22 (1.01-1.46, p (trend)=0.039)). The association was stronger among older subjects carrying at least one copy of the C allele (OR (95% CI)=1.38 (1.04-1.83, P=0.026). Mortality was increased among minor allele carriers (HR(95% CI)=1.33 (1.03-1.72, P=0.029)), with the association largely restricted to females (HR (95% CI)=2.02 (1.28-3.17, P=0.002))."
genetics_GWAS	hsa-mir-101	"Carcinoma, Ovarian"	21765906	"a few of which have been found in the genomic fragile regions that are associated with abnormal deletion or amplification in cancer, such as miR-21, miR-101-1, miR-210 and miR-301a."
genetics_GWAS	hsa-mir-21	"Carcinoma, Ovarian"	21765906	"a few of which have been found in the genomic fragile regions that are associated with abnormal deletion or amplification in cancer, such as miR-21, miR-101-1, miR-210 and miR-301a."
genetics_GWAS	hsa-mir-210	"Carcinoma, Ovarian"	21765906	"a few of which have been found in the genomic fragile regions that are associated with abnormal deletion or amplification in cancer, such as miR-21, miR-101-1, miR-210 and miR-301a."
genetics_GWAS	hsa-mir-301a	"Carcinoma, Ovarian"	21765906	"a few of which have been found in the genomic fragile regions that are associated with abnormal deletion or amplification in cancer, such as miR-21, miR-101-1, miR-210 and miR-301a."
genetics_GWAS	hsa-mir-155	Hypertrophy	21771600	the C allele of rs5186 was associated with a significant increase in SWT (p=0.003) and LVM (p=0.001). This functional polymorphism increases expression of AGTR1 by altering the binding site for miR-155
genetics_GWAS	hsa-mir-125a	Habitual Abortion	21788734	"Two common SNPs (rs41275794, rs12976445) in pri-miR-125a alter the mature miRNA expression and associate with Abortion, Habitual in a Han-Chinese population."
genetics_GWAS	hsa-mir-367	Breast Neoplasms	21810988	"Functional SNP (rs1044129, is present in binding region) in the microRNA-367 binding site in the 3'UTR of the calcium channel ryanodine receptor gene 3 (RYR3) affects breast cancer risk and calcification."
genetics_GWAS	hsa-mir-196a-2	Colorectal Carcinoma	21815818	A Functional Polymorphism (rs11614913 (T>C)) in miRNA-196a2 Is Associated with Colorectal Cancer Risk in a Chinese Population.
genetics_GWAS	hsa-mir-542	Colorectal Carcinoma	21822307	A common single-nucleotide polymorphism (T8473CA) in cyclooxygenase-2 disrupts microRNA (miR-542-3p)-mediated regulation.
genetics_GWAS	hsa-mir-637	Hypertension	21846868	ATP6V0A1 Polymorphism and MicroRNA-637 may have A Pathogenetic Role for MicroRNAs in Essential Hypertension.
genetics_GWAS	hsa-mir-146a	"Carcinoma, Lung, Non-Small-Cell"	21902575	CG genotype of miR-146a(rs2910164 C-G) appeared associated to an increased risk for NSCLC (p=0.042 and 1.77 OR).
genetics_GWAS	hsa-mir-146b	"Carcinoma, Lung, Non-Small-Cell"	21902575	CG genotype of miR-146a(rs2910164 C-G) appeared associated to an increased risk for NSCLC (p=0.042 and 1.77 OR).
genetics_GWAS	hsa-mir-196a-2	"Carcinoma, Lung, Non-Small-Cell"	21902575	"The authors clearly detected a significant increase (p<0.001) of miR-196a2 expression in NSCLC. In particular the authors found a significant association between miR-196a2 (rs11614913 C-T) CC genotype and high expression, whereas TT genotype showed a very low expression in comparison to both CT (p<0.005) and CC patients (p<0.01)."
genetics_GWAS	hsa-mir-137	Schizophrenia	21926974	"GWAS analysis revealed that rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development was associated with schizophrenia."
genetics_GWAS	hsa-mir-184	"Squamous Cell Carcinoma, Head and Neck"	21934093	"The authors found that, compared with the rs8126 TT (a SNP of miR-184 Binding Site in TNFAIP2) genotype, the variant C allele were associated with increased SCCHN risk in an allele-dose response manner (adjusted odds ratio=1.48 and 95% confidence interval=1.06-2.05 for CC, respectively; P(trend)=0.009)."
genetics_GWAS	hsa-mir-149	Gastric Neoplasms	21976437	"Marginally significant associations were found both for hsa-miR-149 rs2292832 with gastric cancer risk (TC+CC vs. TT, OR=0.68, 95% CI: 0.44-1.04) and for hsa-miR-605 rs2043556 with colorectal cancer risk (AG+GG vs. AA, OR=0.70, 95% CI: 0.48-1.02) in males."
genetics_GWAS	hsa-mir-605	Gastric Neoplasms	21976437	"Marginally significant associations were found both for hsa-miR-149 rs2292832 with gastric cancer risk (TC+CC vs. TT, OR=0.68, 95% CI: 0.44-1.04) and for hsa-miR-605 rs2043556 with colorectal cancer risk (AG+GG vs. AA, OR=0.70, 95% CI: 0.48-1.02) in males."
genetics_GWAS	hsa-mir-146a	Thyroid Neoplasms	21978540	"Despite some limitations, this meta-analysis suggests that the miR-146a G allele is a low-penetrant risk factor for papillary thyroid carcinoma development."
genetics_GWAS	hsa-mir-218-1	"Carcinoma, Hepatocellular"	22011248	"The AG genotype of pri-miR-218 rs11134527 A/G was associated with family history (p=0.018, odds ratio [OR]=2.96, 95% confidence interval [CI]: 1.16-7.56) and elevated serum alpha-fetoprotein (serum alpha-fetoprotein [AFP]) levels (¡Ý20 ng/mL; p=0.009, OR=1.92, 95% CI: 1.17-3.14) in HCC patients. These findings suggested that the AG genotype of pri-miR-218 rs11134527 might relate to genetic predisposition and be involved in regulating the expression of AFP in Chinese HCC patients."
genetics_GWAS	hsa-mir-218-2	"Carcinoma, Hepatocellular"	22011248	"The AG genotype of pri-miR-218 rs11134527 A/G was associated with family history (p=0.018, odds ratio [OR]=2.96, 95% confidence interval [CI]: 1.16-7.56) and elevated serum alpha-fetoprotein (serum alpha-fetoprotein [AFP]) levels (¡Ý20 ng/mL; p=0.009, OR=1.92, 95% CI: 1.17-3.14) in HCC patients. These findings suggested that the AG genotype of pri-miR-218 rs11134527 might relate to genetic predisposition and be involved in regulating the expression of AFP in Chinese HCC patients."
genetics_GWAS	hsa-mir-499a	Rheumatoid Arthritis	22019503	"There was a significant difference in the levels of CRP and ESR among different genotypes in rs3746444 (hsa-mir-499) (p = 0.031 and p = 0.047, respectively) in Chinese Han people. The heterozygote CT had significantly higher levels of CRP and ESR compared with homozygotes CC and TT."
genetics_GWAS	hsa-mir-423	Colorectal Carcinoma	22028396	"Two SNPs were identified to be significantly associated with recurrence-free survival and overall survival of the patients. The most significant SNP was rs6505162 in pre-miR-423. Compared to the homozygous wild-type genotype, the variant-containing genotypes of this SNP were significantly associated with both the overall survival (HR=2.12, 95% CI1.34--3.34, P=0.001) and the recurrence-free survival (HR=1.59, 95% CI1.08--2.36, P=0.019). Another SNP, rs4919510 in pre-miR-608, was also associated with altered recurrence-free survival (HR=0.61, 95% CI 0.41-0.92, P=0.017). These effects were evident only in patients receiving chemotherapy but not in those without chemotherapy. In addition, the combined analysis of the two SNPs conferred a 2.84-fold (95% CI 1.50-5.37, P=0.001) increased risk of recurrence and/or death. Similarly, this effect was only prominent in those receiving chemotherapy (P<0.001) but not in those without chemotherapy (P=0.999)."
genetics_GWAS	hsa-mir-608	Colorectal Carcinoma	22028396	"Two SNPs were identified to be significantly associated with recurrence-free survival and overall survival of the patients. The most significant SNP was rs6505162 in pre-miR-423. Compared to the homozygous wild-type genotype, the variant-containing genotypes of this SNP were significantly associated with both the overall survival (HR=2.12, 95% CI1.34--3.34, P=0.001) and the recurrence-free survival (HR=1.59, 95% CI1.08--2.36, P=0.019). Another SNP, rs4919510 in pre-miR-608, was also associated with altered recurrence-free survival (HR=0.61, 95% CI 0.41-0.92, P=0.017). These effects were evident only in patients receiving chemotherapy but not in those without chemotherapy. In addition, the combined analysis of the two SNPs conferred a 2.84-fold (95% CI 1.50-5.37, P=0.001) increased risk of recurrence and/or death. Similarly, this effect was only prominent in those receiving chemotherapy (P<0.001) but not in those without chemotherapy (P=0.999)."
genetics_GWAS	hsa-mir-196a-2	Breast Neoplasms	22074121	"The Chinese women with menarche age less than 16 years had increased breast cancer risk (OR = 2.10, 95% CI: 1.23-3.60). Marginally significant association between rs11614913 (hsa-miR-196a-2) CT/CC genotypes and reduced breast cancer risk was observed (OR = 0.65, 95% CI: 0.40-1.06),"
genetics_GWAS	hsa-mir-502	"Carcinoma, Hepatocellular"	22095217	"We analysed a single nucleotide polymorphism (rs16917496) within the miR-502 microRNA seed region for the 3' UTR of SET8 in Chinese hepatocellular carcinoma (HCC) patients. The SET8 CC genotype was independently associated with longer post-operative survival in HCC patients by multivariate analysis (relative risk, 0.175; 95% CI, 0.053 - 0.577; p = 0.004). The SET8 CC genotype was associated with reduced SET8 protein levels based on the immunostaining of 51 HCC tissue samples. We also found the low SET8 levels was associated with longer HCC survival. Our data suggest that SET8 modifies HCC outcome by altering its expression, which depends, at least in part, on its binding affinity with miR502."
genetics_GWAS	hsa-mir-30c-1	Gastric Neoplasms	22108846	"The genotype frequencies of pre-miR-30c A/G (Polymorphism rs928508 in pre-miR-30c) in gastric cancer patients were obviously different from those in the controls (P = 0.022). AA genotype carriers were associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio (OR) = 1.83, 95% confidence interval (CI): 1.07-3.15, P = 0.029). Moreover, the gastric cancer risk especially elevated in older individuals (aged >60 years), males, nonsmokers, and Helicobacter pylori (H. pylori)-infected individuals (adjusted OR = 2.66, 95% CI: 1.38-5.13, P = 0.004; adjusted OR = 1.90, 95% CI: 1.10-3.27, P = 0.022; adjusted OR = 1.94, 95% CI: 1.12-3.35, P = 0.018; adjusted OR = 1.83, 95% CI: 1.08-3.10, P = 0.024, respectively). Further stratified analysis indicated that AA genotype facilitated developing of gastric cancer with lymph node metastasis (adjusted OR = 2.23, 95% CI: 1.07-4.64, P = 0.032). Expression analysis detected that rs928508 AA showed a significantly increased level of mature miR-30c compared with GG or AG/GG genotype (P = 0.011 or P = 0.013). Patients with AA genotype were associated with unfavorable outcome in overall survival compared with AG/GG genotype (Log rank 5.848, P = 0.016). This study demonstrates that pre-miR-30c A/G polymorphism may be associated with an increased risk of gastric cancer in a Chinese population through altering mature miR-30c expression."
genetics_GWAS	hsa-mir-30c-2	Gastric Neoplasms	22108846	"The genotype frequencies of pre-miR-30c A/G (Polymorphism rs928508 in pre-miR-30c) in gastric cancer patients were obviously different from those in the controls (P = 0.022). AA genotype carriers were associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio (OR) = 1.83, 95% confidence interval (CI): 1.07-3.15, P = 0.029). Moreover, the gastric cancer risk especially elevated in older individuals (aged >60 years), males, nonsmokers, and Helicobacter pylori (H. pylori)-infected individuals (adjusted OR = 2.66, 95% CI: 1.38-5.13, P = 0.004; adjusted OR = 1.90, 95% CI: 1.10-3.27, P = 0.022; adjusted OR = 1.94, 95% CI: 1.12-3.35, P = 0.018; adjusted OR = 1.83, 95% CI: 1.08-3.10, P = 0.024, respectively). Further stratified analysis indicated that AA genotype facilitated developing of gastric cancer with lymph node metastasis (adjusted OR = 2.23, 95% CI: 1.07-4.64, P = 0.032). Expression analysis detected that rs928508 AA showed a significantly increased level of mature miR-30c compared with GG or AG/GG genotype (P = 0.011 or P = 0.013). Patients with AA genotype were associated with unfavorable outcome in overall survival compared with AG/GG genotype (Log rank 5.848, P = 0.016). This study demonstrates that pre-miR-30c A/G polymorphism may be associated with an increased risk of gastric cancer in a Chinese population through altering mature miR-30c expression."
genetics_GWAS	hsa-mir-629	Lung Neoplasms	22114071	"The rs2735383CC (NBS1 gene) genotype had a significantly increased risk of lung cancer under a recessive genetic model in the total 1559 cases versus 1679 controls (OR = 1.40, 95% C.I. = 1.18-1.66, P = 0.0001) when compared with GG or GC genotypes; the rs2735383CC genotype carriers had lower mRNA and protein expression levels in tumor tissues than those of other genotypes as qPCR and western blot shown. Luciferase assay revealed that the rs2735383C allele had a lower transcription activity than G allele; and the hsa-miR-629 but not hsa-miR-499-5P had effect on modulation of NBS1 gene in vitro. We further observed that the X-ray radiation induced more chromatid breaks in lymphocyte cells from the carriers of rs2735383CC homozygote than those from the subjects with other genotypes (P = 0.0008). Our data suggested that the rs2735383G>C variation contributes to an increased risk of lung cancer by diminishing gene's expression through binding of microRNA-629 to the polymorphic site in the 3'-UTR of NBS1 gene."
genetics_GWAS	hsa-mir-196a-2	Coronary Artery Disease	22159951	"The variant genotypes CC/CT of hsa-mir-196a2 rs11614913 T ¡ú C were not associated with a significantly increased risk of CAD (adjusted OR = 1.02, 95% CI = 0.76-1.38), compared with wide genotype TT, but CC and CC/CT genotypes were associated with 34 and 35% increased risks of serious prognosis of CAD (adjusted HR = 1.34, 95% CI = 1.02-1.75 for CC; adjusted HR = 1.35, 95% CI = 1.03-1.75 for CC/CT). In the variant of hsa-mir-499 rs3746444A ¡ú G, GG was associated with the 223% increased risk of CAD (adjusted OR = 3.23, 95% CI = 1.56-6.67). Cox regression analysis showed that age, smoking status, numbers of pathological changes in coronary arteries, rs11614913 T ¡ú C, and diabetes mellitus were associated with serious prognosis of CAD."
genetics_GWAS	hsa-mir-499a	Coronary Artery Disease	22159951	"The variant genotypes CC/CT of hsa-mir-196a2 rs11614913 T ¡ú C were not associated with a significantly increased risk of CAD (adjusted OR = 1.02, 95% CI = 0.76-1.38), compared with wide genotype TT, but CC and CC/CT genotypes were associated with 34 and 35% increased risks of serious prognosis of CAD (adjusted HR = 1.34, 95% CI = 1.02-1.75 for CC; adjusted HR = 1.35, 95% CI = 1.03-1.75 for CC/CT). In the variant of hsa-mir-499 rs3746444A ¡ú G, GG was associated with the 223% increased risk of CAD (adjusted OR = 3.23, 95% CI = 1.56-6.67). Cox regression analysis showed that age, smoking status, numbers of pathological changes in coronary arteries, rs11614913 T ¡ú C, and diabetes mellitus were associated with serious prognosis of CAD."
genetics_GWAS	hsa-mir-196a-2	Colorectal Carcinoma	22161766	The authors found a significantly increased colorectal cancer risk with the miR-196a2CC (rs11614913) genotype compared with the TT/CT genotype (AOR=1.50; 95% CI=1.11-2.04; P=0.01; FDR-P=0.04) in Korean population.
genetics_GWAS	hsa-mir-146a	"Squamous Cell Carcinoma, Oral"	22182931	"This study identifies that areca nut extract, TNFalpha and TGFbeta up-regulates miR-146a in OSCC cells. The increased expression of miR-146a enhanced the oncogenicity of OSCC cells. In addition, a G to C polymorphism (rs2910164), which is located in the pre-miR-146a and has been associated with functional alterations in miR-146a, was significantly more prevalent among OSCC patients having more advanced nodal involvement. Our analysis also suggested a higher miR-146a expression in OSCC tissues of patients carrying C polymorphism. The present study concluded a higher prevalence of the pre-mir-146a C-variant was associated with OSCC progression in patients with this disease."
genetics_GWAS	hsa-mir-570	Gastric Neoplasms	22190470	A guanine-to-cytosine mutation at the 3'-UTR of CD274 mRNA led to CD274 over-expression by disrupting the miR-570 binding. A frequent somatic mutation in CD274 3'-UTR leads to protein over-expression in gastric cancer by disrupting miR-570 binding.
genetics_GWAS	hsa-mir-200b	Endometrial Neoplasms	22194984	Luciferase assays and Western blot analysis demonstrated that the miR-200b/200c/429 family recognized the MRE in the 3' UTR of AP-2alpha gene and negatively regulated the expression of endogenous AP-2alpha proteins. SNP rs1045385 A>C variation enhanced AP-2alpha.
genetics_GWAS	hsa-mir-200c	Endometrial Neoplasms	22194984	Luciferase assays and Western blot analysis demonstrated that the miR-200b/200c/429 family recognized the MRE in the 3' UTR of AP-2 alpha gene and negatively regulated the expression of endogenous AP-2 alpha proteins. SNP rs1045385 A>C variation enhanced AP-2 alpha expression.
genetics_GWAS	hsa-mir-429	Endometrial Neoplasms	22194984	Luciferase assays and Western blot analysis demonstrated that the miR-200b/200c/429 family recognized the MRE in the 3' UTR of AP-2 alpha gene and negatively regulated the expression of endogenous AP-2 alpha proteins. SNP rs1045385 A>C variation enhanced AP-2 alpha expression.
genetics_GWAS	hsa-mir-146a	Systemic Lupus Erythematosus	22218224	"The SNP (rs2431697) was associated with the microRNA-146a, where the risk allele correlates with lower expression of the miRNA."
genetics_GWAS	hsa-mir-196a-2	Habitual Abortion	22222140	"RSA(recurrent spontaneous abortion) patients exhibited significantly different frequencies of the miR-196a2CC (TT+TC vs. CC; adjusted odds ratio [AOR], 1.587; 95% confidence interval [CI], 1.042-2.417) and miR-499AG+GG genotypes (AOR, 1.671; 95% CI, 1.054-2.651) compared with the control group."
genetics_GWAS	hsa-mir-499a	Habitual Abortion	22222140	"RSA(recurrent spontaneous abortion) patients exhibited significantly different frequencies of the miR-196a2CC (TT+TC vs. CC; adjusted odds ratio [AOR], 1.587; 95% confidence interval [CI], 1.042-2.417) and miR-499AG+GG genotypes (AOR, 1.671; 95% CI, 1.054-2.651) compared with the control group."
genetics_GWAS	hsa-mir-17	Ovarian Neoplasms	22235027	"The most notable cluster is the tumorigenic miR-17-92 cluster with five microRNAs, all of which are significantly associated with rs3814113"
genetics_GWAS	hsa-mir-18a	Ovarian Neoplasms	22235027	"The most notable cluster is the tumorigenic miR-17-92 cluster with five microRNAs, all of which are significantly associated with rs3814113"
genetics_GWAS	hsa-mir-19a	Ovarian Neoplasms	22235027	"The most notable cluster is the tumorigenic miR-17-92 cluster with five microRNAs, all of which are significantly associated with rs3814113"
genetics_GWAS	hsa-mir-19b-1	Ovarian Neoplasms	22235027	"The most notable cluster is the tumorigenic miR-17-92 cluster with five microRNAs, all of which are significantly associated with rs3814113"
genetics_GWAS	hsa-mir-20a	Ovarian Neoplasms	22235027	"The most notable cluster is the tumorigenic miR-17-92 cluster with five microRNAs, all of which are significantly associated with rs3814113"
genetics_GWAS	hsa-mir-92a-1	Ovarian Neoplasms	22235027	"The most notable cluster is the tumorigenic miR-17-92 cluster with five microRNAs, all of which are significantly associated with rs3814113"
genetics_GWAS	hsa-let-7e	Crohn Disease	22262659	The rs10889677 variant in the 3'-untranslated region of the IL-23R gene displays enhanced levels of both mRNA and protein production of IL-23R. This can be attributed to a loss of binding capacity for the microRNAs (miRNAs) Let-7e and Let-7f by the variant allele.
genetics_GWAS	hsa-let-7f-1	Crohn Disease	22262659	The rs10889677 variant in the 3'-untranslated region of the IL-23R gene displays enhanced levels of both mRNA and protein production of IL-23R. This can be attributed to a loss of binding capacity for the microRNAs (miRNAs) Let-7e and Let-7f by the variant allele.
genetics_GWAS	hsa-let-7f-2	Crohn Disease	22262659	The rs10889677 variant in the 3'-untranslated region of the IL-23R gene displays enhanced levels of both mRNA and protein production of IL-23R. This can be attributed to a loss of binding capacity for the microRNAs (miRNAs) Let-7e and Let-7f by the variant allele.
genetics_GWAS	hsa-let-7a-1	Endometriosis	22307873	The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population.
genetics_GWAS	hsa-let-7a-2	Endometriosis	22307873	The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population.
genetics_GWAS	hsa-let-7a-3	Endometriosis	22307873	The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population.
genetics_GWAS	hsa-let-7b	Endometriosis	22307873	The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population.
genetics_GWAS	hsa-let-7c	Endometriosis	22307873	The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population.
genetics_GWAS	hsa-let-7d	Endometriosis	22307873	The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population.
genetics_GWAS	hsa-let-7e	Endometriosis	22307873	The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population.
genetics_GWAS	hsa-let-7f-1	Endometriosis	22307873	The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population.
genetics_GWAS	hsa-let-7f-2	Endometriosis	22307873	The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population.
genetics_GWAS	hsa-let-7g	Endometriosis	22307873	The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population.
genetics_GWAS	hsa-let-7i	Endometriosis	22307873	The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population.
genetics_GWAS	hsa-mir-1207	Glomerulonephritis	22319602	"A miR-1207-5p binding site polymorphism (C1936T, rs13385) abolishes regulation of HBEGF and is associated with disease severity in CFHR5 nephropathy."
genetics_GWAS	hsa-mir-155	"Lymphoma, Non-Hodgkin"	22347493	"Variant rs928883, near miR-155, showed an association (OR per A-allele: 2.80 [95% CI: 1.63-4.82]; p(F)=0.027) with marginal zone lymphoma that is significant after correction for multiple testing."
genetics_GWAS	hsa-mir-1273c	Colorectal Carcinoma	22348132	"hsa-mir-1273c, hsa-mir-1303 and hsa-mir-567, with frequent and sometimes bi-allelic mutations in MSI tumors."
genetics_GWAS	hsa-mir-1303	Colorectal Carcinoma	22348132	"hsa-mir-1273c, hsa-mir-1303 and hsa-mir-567, with frequent and sometimes bi-allelic mutations in MSI tumors."
genetics_GWAS	hsa-mir-567	Colorectal Carcinoma	22348132	"hsa-mir-1273c, hsa-mir-1303 and hsa-mir-567, with frequent and sometimes bi-allelic mutations in MSI tumors."
genetics_GWAS	hsa-mir-25	Lung Neoplasms	22349819	REV3L 3'UTR 460 T>C polymorphism in microRNA(miR-25/32) target sites contributes to lung cancer susceptibility.
genetics_GWAS	hsa-mir-32	Lung Neoplasms	22349819	REV3L 3'UTR 460 T>C polymorphism in microRNA(miR-25/32) target sites contributes to lung cancer susceptibility.
genetics_GWAS	hsa-mir-27a	Gastric Neoplasms	22350505	The SNP rs895819 in the miR-27a gene with the minor allele C presented significantly reduced risk to gastric cancer in Chinese population.
genetics_GWAS	hsa-mir-146a	Breast Neoplasms	22363415	"The authors found that hs-miR-196a2 in premenopausal patients, and hs-miR-499, hs-miR-146a and hs-miR-196a2 in postmenopausal patients, may discriminate breast cancer patients from healthy individuals. In addition, we found a significant association between two microRNA polymorphisms (hs-miR-196a2 and hs-miR-499) and breast cancer risk."
genetics_GWAS	hsa-mir-196a-2	Breast Neoplasms	22363415	"The authors found that hs-miR-196a2 in premenopausal patients, and hs-miR-499, hs-miR-146a and hs-miR-196a2 in postmenopausal patients, may discriminate breast cancer patients from healthy individuals. In addition, we found a significant association between two microRNA polymorphisms (hs-miR-196a2 and hs-miR-499) and breast cancer risk."
genetics_GWAS	hsa-mir-499a	Breast Neoplasms	22363415	"The authors found that hs-miR-196a2 in premenopausal patients, and hs-miR-499, hs-miR-146a and hs-miR-196a2 in postmenopausal patients, may discriminate breast cancer patients from healthy individuals. In addition, we found a significant association between two microRNA polymorphisms (hs-miR-196a2 and hs-miR-499) and breast cancer risk."
genetics_GWAS	hsa-mir-146a	Breast Neoplasms	22363684	Increased Risk of Breast Cancer Associated with CC Genotype of Has-miR-146a Rs2910164 Polymorphism in Europeans.
genetics_GWAS	hsa-mir-499a	Heart Failure	22374132	A naturally occurring miR-499 mutation(u17c in the 3' end) outside the critical seed sequence modifies mRNA targeting and end-organ function.
genetics_GWAS	hsa-mir-106b	"Carcinoma, Hepatocellular"	22393390	"A Genetic Variant (rs999885) in the Promoter Region of miR-106b-25 Cluster and Risk of HBV Infection and Hepatocellular Carcinoma.Compared with the HBV natural clearance subjects carrying rs999885 AA genotype, those with AG/GG genotypes had a decreased risk of chronic HBV infection with an adjusted odds ratio (OR) of 0.79 [95% confidence intervals (CIs)=0.67-0.93]. However, the AG/GG genotypes were significantly associated with an increased HCC risk in HBV persistent carriers (adjusted OR=1.25, 95% CIs=1.06-1.47). Expression analysis revealed that the expression level of miR-106b-25 cluster was significantly higher in AG/GG carriers than those in AA carriers in non-tumor liver tissues."
genetics_GWAS	hsa-mir-106b	Hepatitis B Virus Infection	22393390	"A Genetic Variant (rs999885) in the Promoter Region of miR-106b-25 Cluster and Risk of HBV Infection and Hepatocellular Carcinoma.Compared with the HBV natural clearance subjects carrying rs999885 AA genotype, those with AG/GG genotypes had a decreased risk of chronic HBV infection with an adjusted odds ratio (OR) of 0.79 [95% confidence intervals (CIs)=0.67-0.93]. However, the AG/GG genotypes were significantly associated with an increased HCC risk in HBV persistent carriers (adjusted OR=1.25, 95% CIs=1.06-1.47). Expression analysis revealed that the expression level of miR-106b-25 cluster was significantly higher in AG/GG carriers than those in AA carriers in non-tumor liver tissues."
genetics_GWAS	hsa-mir-25	"Carcinoma, Hepatocellular"	22393390	"A Genetic Variant (rs999885) in the Promoter Region of miR-106b-25 Cluster and Risk of HBV Infection and Hepatocellular Carcinoma.Compared with the HBV natural clearance subjects carrying rs999885 AA genotype, those with AG/GG genotypes had a decreased risk of chronic HBV infection with an adjusted odds ratio (OR) of 0.79 [95% confidence intervals (CIs)=0.67-0.93]. However, the AG/GG genotypes were significantly associated with an increased HCC risk in HBV persistent carriers (adjusted OR=1.25, 95% CIs=1.06-1.47). Expression analysis revealed that the expression level of miR-106b-25 cluster was significantly higher in AG/GG carriers than those in AA carriers in non-tumor liver tissues."
genetics_GWAS	hsa-mir-25	Hepatitis B Virus Infection	22393390	"A Genetic Variant (rs999885) in the Promoter Region of miR-106b-25 Cluster and Risk of HBV Infection and Hepatocellular Carcinoma.Compared with the HBV natural clearance subjects carrying rs999885 AA genotype, those with AG/GG genotypes had a decreased risk of chronic HBV infection with an adjusted odds ratio (OR) of 0.79 [95% confidence intervals (CIs)=0.67-0.93]. However, the AG/GG genotypes were significantly associated with an increased HCC risk in HBV persistent carriers (adjusted OR=1.25, 95% CIs=1.06-1.47). Expression analysis revealed that the expression level of miR-106b-25 cluster was significantly higher in AG/GG carriers than those in AA carriers in non-tumor liver tissues."
genetics_GWAS	hsa-mir-325	Dyspepsia	22438098	"Genetic polymorphism ( rs5981521 (C>T)) of pri-microRNA 325, targeting SLC6A4 3'-UTR, is closely associated with the risk of functional dyspepsia in Japan."
genetics_GWAS	hsa-mir-146a	Gastric Neoplasms	22455393	A Functional Polymorphism (rs2910164) in Pre-miR-146a Is Associated with Susceptibility to Gastric Cancer in a Chinese Population.
genetics_GWAS	hsa-mir-938	Gastric Neoplasms	22537748	"Genetic polymorphisms of IL17A ((rs2275913 (-197 G > A), rs3748067 (*1249 C > T)) and pri-microRNA-938 (pri-miR-938, rs2505901 (T > C).), targeting IL17A 3'-UTR, influence susceptibility to gastric cancer."
genetics_GWAS	hsa-mir-520a	Colorectal Carcinoma	22553375	A 3' untranslated region (UTR) mutation was also shown to be associated with increased sensitivity to saracatinib and have a reduced affinity for miR-520a and miR-525a.
genetics_GWAS	hsa-mir-608	Breast Neoplasms	22586447	Polymorphism rs4919510:C>G in mature sequence of human microRNA-608 contributes to the risk of HER2-positive breast cancer but not other subtypes.
genetics_GWAS	hsa-mir-423	Breast Neoplasms	22593246	A genetic variant (rs6505162:A>C) located in miR-423 is associated with reduced breast cancer risk.
genetics_GWAS	hsa-mir-608	Colorectal Carcinoma	22606253	rs4919510 in hsa-mir-608 is associated with outcome but not risk of colorectal cancer.
genetics_GWAS	hsa-mir-146a	Moyamoya Disease	22659075	"Association of the miR-146aC>G, miR-196a2C>T, and miR-499A>G polymorphisms with moyamoya disease in the Korean population."
genetics_GWAS	hsa-mir-196a-2	Moyamoya Disease	22659075	"Association of the miR-146aC>G, miR-196a2C>T, and miR-499A>G polymorphisms with moyamoya disease in the Korean population."
genetics_GWAS	hsa-mir-219-1	Colorectal Carcinoma	22661538	"The mir219-1:rs213210 showed consistent association with death in the training set, the replication set, and combined data set"
genetics_GWAS	hsa-mir-608	Colorectal Carcinoma	22661538	"In patients with stage III disease, mir608: rs4919510 was associated with increased risk for both recurrence and death."
genetics_GWAS	hsa-mir-146a	Nasopharyngeal Neoplasms	22711332	A single nucleotide polymorphism (rs2910164) in microRNA-146a is associated with the risk for nasopharyngeal carcinoma.
genetics_GWAS	hsa-mir-182	Melanoma	22752337	Up-regulation of miR-182 expression after epigenetic modulation of human melanoma cells.
genetics_GWAS	hsa-mir-499a	"Squamous Cell Carcinoma, Oral"	22761899	"This study determined that a significant association of miRNA499 with CC genotype, as compared to the subjects with TT genotype, had a higher risk of oral squamous cell carcinoma."
genetics_GWAS	hsa-mir-499b	"Squamous Cell Carcinoma, Oral"	22761899	"This study determined that a significant association of miRNA499 with CC genotype, as compared to the subjects with TT genotype, had a higher risk of oral squamous cell carcinoma."
genetics_GWAS	hsa-mir-7-1	Urinary Bladder Cancer	22768238	A microRNA-7 binding site polymorphism (1010A/G) in HOXB5 leads to differential gene expression in bladder cancer.
genetics_GWAS	hsa-mir-7-2	Urinary Bladder Cancer	22768238	A microRNA-7 binding site polymorphism (1010A/G) in HOXB5 leads to differential gene expression in bladder cancer.
genetics_GWAS	hsa-mir-7-3	Urinary Bladder Cancer	22768238	A microRNA-7 binding site polymorphism (1010A/G) in HOXB5 leads to differential gene expression in bladder cancer.
genetics_GWAS	hsa-mir-146a	Lung Neoplasms	22818121	Our findings suggest that polymorphisms in the rs2910164 of miR-146a and the rs11614913 of miR-196a2 are associated with prognosis in patients with completely resected NSCLC.
genetics_GWAS	hsa-mir-196a	Lung Neoplasms	22818121	Our findings suggest that polymorphisms in the rs2910164 of miR-146a and the rs11614913 of miR-196a2 are associated with prognosis in patients with completely resected NSCLC.
genetics_GWAS	hsa-mir-146a	Asthma	22823586	MiR-146a polymorphism is associated with asthma but not with systemic lupus erythematosus and juvenile rheumatoid arthritis in Mexican patients.
genetics_GWAS	hsa-mir-1231	"Carcinoma, Hepatocellular"	22824466	A miR-1231 binding site polymorphism (rs17875871) in the 3'UTR of IFNAR1 is associated with hepatocellular carcinoma susceptibility.
genetics_GWAS	hsa-mir-125b-1	"Leukemia, Myeloid, Acute"	22843432	MicroRNA-125b-1 accelerates a C-terminal mutant of C/EBP¦Á (C/EBP¦Á-C(m))-induced myeloid leukemia.
genetics_GWAS	hsa-mir-34b	Intracranial Aneurysm	22844323	"The CC genotype of miR-34b/c rs4938723 was significantly associated with a decreased risk of IA compared with the TT genotype. Moreover, a significant gene interaction of the carriers with the combined genotypes of miR-34b/c rs4938723CC and TP53 Arg72Pro CG/CC/GG had a decreased risk of IA, compared with those carrying miR-34b/c rs4938723CT/TT+TP53 Arg72Pro GG/CG/CC combined genotypes."
genetics_GWAS	hsa-mir-34c	Intracranial Aneurysm	22844323	"The CC genotype of miR-34b/c rs4938723 was significantly associated with a decreased risk of IA compared with the TT genotype. Moreover, a significant gene interaction of the carriers with the combined genotypes of miR-34b/c rs4938723CC and TP53 Arg72Pro CG/CC/GG had a decreased risk of IA, compared with those carrying miR-34b/c rs4938723CT/TT+TP53 Arg72Pro GG/CG/CC combined genotypes."
genetics_GWAS	hsa-mir-146a	Urinary Bladder Cancer	22846912	miR-146a rs2910164 C allele inhibited cell proliferation and significantly downregulates expression of IRAK1 and TRAF6 in bladder cancer cells.
genetics_GWAS	hsa-mir-196a-1	Esophageal Neoplasms	22859270	MiR-196a binding-site SNP (rs6573) regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis.
genetics_GWAS	hsa-mir-196a-2	Esophageal Neoplasms	22859270	MiR-196a binding-site SNP (rs6573) regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis.
genetics_GWAS	hsa-mir-502	Ovarian Neoplasms	22867998	A polymorphism (rs16917496) at the miR-502 binding site in the 3' untranslated region of the SET8 gene is associated with the risk of epithelial ovarian cancer.
genetics_GWAS	hsa-let-7a-2	Ovarian Neoplasms	22970210	"We found that there was a reduction in the copy number of let-7 genes in a cancer-type specific manner. Importantly, focal deletion of four let-7 family members was found in three cancer types: medulloblastoma (let-7a-2 and let-7e), breast cancer (let-7a-2), and ovarian cancer (let-7a-3/let-7b)."
genetics_GWAS	hsa-let-7e	Ovarian Neoplasms	22970210	"We found that there was a reduction in the copy number of let-7 genes in a cancer-type specific manner. Importantly, focal deletion of four let-7 family members was found in three cancer types: medulloblastoma (let-7a-2 and let-7e), breast cancer (let-7a-2), and ovarian cancer (let-7a-3/let-7b)."
genetics_GWAS	hsa-mir-499	Breast Neoplasms	23053947	"In conclusion, this meta-analysis suggests that the miR-499 rs3746444 polymorphism (A>G) is a low-penetrant risk factor for cancer development among Asians and may contribute to breast cancer susceptibility."
genetics_GWAS	hsa-mir-337	"Leukemia, Myeloid, Acute"	23065518	A polymorphism in the 3'-untranslated region of the NPM1 gene causes illegitimate regulation by microRNA-337-5p and correlates with adverse outcome in acute myeloid leukemia
genetics_GWAS	hsa-mir-200c	Gastric Neoplasms	23065816	G-A variant in miR-200c binding site of EFNA1 alters susceptibility to gastric cancer
genetics_GWAS	hsa-mir-370	"Leukemia, Myeloid, Acute"	23077663	Integration of SNP and mRNA arrays with microRNA profiling reveals that MiR-370 is upregulated and targets NF1 in acute myeloid leukemia
genetics_GWAS	hsa-mir-27a	"Carcinoma, Renal Cell"	23118855	A genetic variant in pre-miR-27a is associated with a reduced renal cell cancer risk in a Chinese population
genetics_GWAS	hsa-mir-196a-1	Lung Neoplasms	23143626	Hsa-miR-196a2 functional SNP is associated with severe toxicity after platinum-based chemotherapy of advanced nonsmall cell lung cancer patients in a Chinese population
genetics_GWAS	hsa-mir-196a-2	Lung Neoplasms	23143626	Hsa-miR-196a2 functional SNP is associated with severe toxicity after platinum-based chemotherapy of advanced nonsmall cell lung cancer patients in a Chinese population
genetics_GWAS	hsa-mir-30c-1	Lung Neoplasms	23159078	Single nucleotide polymorphism in flanking region of miR-30c influences the maturing process of miR-30c in lung carcinoma
genetics_GWAS	hsa-mir-30c-2	Lung Neoplasms	23159078	Single nucleotide polymorphism in flanking region of miR-30c influences the maturing process of miR-30c in lung carcinoma
genetics_GWAS	hsa-mir-146a	Acute Cerebral Infarction	23202363	"Association of the miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms With Ischemic Stroke and Silent Brain Infarction Risk"
genetics_GWAS	hsa-mir-149	Acute Cerebral Infarction	23202363	"Association of the miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms With Ischemic Stroke and Silent Brain Infarction Risk"
genetics_GWAS	hsa-mir-196a-1	Acute Cerebral Infarction	23202363	"Association of the miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms With Ischemic Stroke and Silent Brain Infarction Risk"
genetics_GWAS	hsa-mir-196a-2	Acute Cerebral Infarction	23202363	"Association of the miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms With Ischemic Stroke and Silent Brain Infarction Risk"
genetics_GWAS	hsa-mir-146a	Melanoma	23222547	The rs2910164 G>C polymorphism in microRNA-146a is associated with the incidence of malignant melanoma
genetics_GWAS	hsa-mir-196a-1	Breast Neoplasms	23228090	Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer
genetics_GWAS	hsa-mir-196a-2	Breast Neoplasms	23228090	Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer
genetics_GWAS	hsa-mir-27a	Gastric Neoplasms	23246964	Genetic variations in miR-27a gene decrease mature miR-27a level and reduce gastric cancer susceptibility
genetics_GWAS	hsa-mir-146a	Behcet Disease	23268366	MicroRNA-146a and Ets-1 gene polymorphisms in ocular Behcet's disease and Vogt-Koyanagi-Harada syndrome
genetics_GWAS	hsa-mir-885	Head And Neck Neoplasms	23271051	A functional variant at the miR-885-5p binding site of CASP3 confers risk of both index and second primary malignancies in patients with head and neck cancer
genetics_GWAS	hsa-mir-149	"Squamous Cell Carcinoma, Head and Neck"	23272122	The Association between Genetic Polymorphism and the Processing Efficiency of miR-149 Affects the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma
genetics_GWAS	hsa-mir-146a	Hepatitis B Virus Infection	23292505	Association of a single-nucleotide polymorphism within the miR-146a gene with susceptibility for acute-on-chronic hepatitis B liver failure
genetics_GWAS	hsa-mir-146a	Colorectal Carcinoma	23306950	A genetic variant in miR-146a modifies colorectal cancer susceptibility in a chinese population
genetics_GWAS	hsa-mir-218-1	Urinary Bladder Cancer	23320911	The pri-miR-218 rs11134527 SNP was significantly associated with the risk of cervical carcinoma in Eastern Chinese women
genetics_GWAS	hsa-mir-218-2	Urinary Bladder Cancer	23320911	The pri-miR-218 rs11134527 SNP was significantly associated with the risk of cervical carcinoma in Eastern Chinese women
genetics_GWAS	hsa-mir-520a	Endometriosis	23364396	A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women
genetics_GWAS	hsa-mir-520b	Endometriosis	23364396	A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women
genetics_GWAS	hsa-mir-520c	Endometriosis	23364396	A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women
genetics_GWAS	hsa-mir-520d	Endometriosis	23364396	A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women
genetics_GWAS	hsa-mir-520e	Endometriosis	23364396	A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women
genetics_GWAS	hsa-mir-520f	Endometriosis	23364396	A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women
genetics_GWAS	hsa-mir-520g	Endometriosis	23364396	A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women
genetics_GWAS	hsa-mir-520h	Endometriosis	23364396	A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women
genetics_GWAS	hsa-mir-22	Heart Failure	23372812	Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass.
genetics_GWAS	hsa-mir-367	Colorectal Carcinoma	23393343	the functional variant (rs1044129) in the miR-367 binding site of RYR3 may be a potential marker for prognosis in patients following curative surgery for CRC
genetics_GWAS	hsa-mir-151a	Nasopharyngeal Neoplasms	23416081	A miR-151 binding site polymorphism in the 3'-untranslated region of the cyclin E1 gene associated with nasopharyngeal carcinoma
genetics_GWAS	hsa-mir-151b	Nasopharyngeal Neoplasms	23416081	A miR-151 binding site polymorphism in the 3'-untranslated region of the cyclin E1 gene associated with nasopharyngeal carcinoma
genetics_GWAS	hsa-mir-125a	Breast Neoplasms	23420759	rs12976445 variant in the pri-miR-125a correlates with a lower level of hsa-miR-125a and ERBB2 overexpression in breast cancer patients
genetics_GWAS	hsa-mir-196a-2	Vitiligo	23433405	A Single Nucleotide Polymorphism of miR-196a-2 and Vitiligo: An Association Study and Functional Analysis in a Han Chinese Population
genetics_GWAS	hsa-mir-146a	Thyroid Neoplasms	23451063	Association between the rs2910164 Polymorphism in Pre-Mir-146a Sequence and Thyroid Carcinogenesis
genetics_GWAS	hsa-mir-34b	Nasopharyngeal Neoplasms	23504554	Interactions of miR-34b/c and TP-53 polymorphisms on the risk of nasopharyngeal carcinoma
genetics_GWAS	hsa-mir-34c	Nasopharyngeal Neoplasms	23504554	Interactions of miR-34b/c and TP-53 polymorphisms on the risk of nasopharyngeal carcinoma
genetics_GWAS	hsa-mir-196a-1	Hepatitis B Virus Infection	23516510	Associations of pri-miR-34b/c and pre-miR-196a2 Polymorphisms and Their Multiplicative Interactions with Hepatitis B Virus Mutations with Hepatocellular Carcinoma Risk
genetics_GWAS	hsa-mir-196a-2	Hepatitis B Virus Infection	23516510	Associations of pri-miR-34b/c and pre-miR-196a2 Polymorphisms and Their Multiplicative Interactions with Hepatitis B Virus Mutations with Hepatocellular Carcinoma Risk
genetics_GWAS	hsa-mir-34b	Hepatitis B Virus Infection	23516510	Associations of pri-miR-34b/c and pre-miR-196a2 Polymorphisms and Their Multiplicative Interactions with Hepatitis B Virus Mutations with Hepatocellular Carcinoma Risk
genetics_GWAS	hsa-mir-34c	Hepatitis B Virus Infection	23516510	Associations of pri-miR-34b/c and pre-miR-196a2 Polymorphisms and Their Multiplicative Interactions with Hepatitis B Virus Mutations with Hepatocellular Carcinoma Risk
genetics_GWAS	hsa-mir-196a	Neoplasms [unspecific]	23691458	"The meta-analysis demonstrated that the miR-196a-2 polymorphism is associated with cancer susceptibility, especially lung cancer, colorectal cancer, and breast cancer among Asian populations."
genetics_GWAS	hsa-mir-184	Gastric Neoplasms	23724109	The miR-184 Binding-Site rs8126 T>C Polymorphism in TNFAIP2 Is Associated with Risk of Gastric Cancer.
genetics_GWAS	hsa-mir-137	Psychiatric Disorders	23786914	Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex.
genetics_GWAS	hsa-mir-196a-2	"Carcinoma, Hepatocellular"	23791656	Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: a systematic review and meta-analysis. 
genetics_GWAS	hsa-mir-499	"Carcinoma, Hepatocellular"	23791656	Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: a systematic review and meta-analysis. 
genetics_GWAS	hsa-mir-146a	"Squamous Cell Carcinoma, Esophageal"	23792053	"These findings indicated that functional polymorphism miR-196a2 rs11614913 T > C might contribute to decreased ESCC risk among women patients and patients who never smoking or drinking. However, our results were obtained with a limited sample size. Future larger studies with other ethnic populations and tissue-specific biological characterization are required to confirm current findings."
genetics_GWAS	hsa-mir-196a-2	"Squamous Cell Carcinoma, Esophageal"	23792053	"These findings indicated that functional polymorphism miR-196a2 rs11614913 T > C might contribute to decreased ESCC risk among women patients and patients who never smoking or drinking. However, our results were obtained with a limited sample size. Future larger studies with other ethnic populations and tissue-specific biological characterization are required to confirm current findings."
genetics_GWAS	hsa-mir-26a-1	"Squamous Cell Carcinoma, Esophageal"	23792053	"These findings indicated that functional polymorphism miR-196a2 rs11614913 T > C might contribute to decreased ESCC risk among women patients and patients who never smoking or drinking. However, our results were obtained with a limited sample size. Future larger studies with other ethnic populations and tissue-specific biological characterization are required to confirm current findings."
genetics_GWAS	hsa-mir-27a	"Squamous Cell Carcinoma, Esophageal"	23792053	"These findings indicated that functional polymorphism miR-196a2 rs11614913 T > C might contribute to decreased ESCC risk among women patients and patients who never smoking or drinking. However, our results were obtained with a limited sample size. Future larger studies with other ethnic populations and tissue-specific biological characterization are required to confirm current findings."
genetics_GWAS	hsa-mir-499	"Squamous Cell Carcinoma, Esophageal"	23792053	"These findings indicated that functional polymorphism miR-196a2 rs11614913 T > C might contribute to decreased ESCC risk among women patients and patients who never smoking or drinking. However, our results were obtained with a limited sample size. Future larger studies with other ethnic populations and tissue-specific biological characterization are required to confirm current findings."
genetics_GWAS	hsa-mir-146a	Coronary Artery Disease	23794009	"miR-146a polymorphism influences levels of miR-146a, IRAK-1, and TRAF-6 in young patients with coronary artery disease."
genetics_GWAS	hsa-mir-608	"Carcinoma, Nasopharyngeal"	23796562	A sequence polymorphism in miR-608 predicts recurrence after radiotherapy for nasopharyngeal carcinoma.
genetics_GWAS	hsa-mir-124	Hepatitis B Virus Infection	23807362	Association between microRNA polymorphisms and humoral immunity to hepatitis B vaccine.
genetics_GWAS	hsa-mir-146a	Hepatitis B Virus Infection	23807362	Association between microRNA polymorphisms and humoral immunity to hepatitis B vaccine.
genetics_GWAS	hsa-mir-149	Hepatitis B Virus Infection	23807362	Association between microRNA polymorphisms and humoral immunity to hepatitis B vaccine.
genetics_GWAS	hsa-mir-196a-2	Hepatitis B Virus Infection	23807362	Association between microRNA polymorphisms and humoral immunity to hepatitis B vaccine.
genetics_GWAS	hsa-mir-26a-1	Hepatitis B Virus Infection	23807362	Association between microRNA polymorphisms and humoral immunity to hepatitis B vaccine.
genetics_GWAS	hsa-mir-27a	Hepatitis B Virus Infection	23807362	Association between microRNA polymorphisms and humoral immunity to hepatitis B vaccine.
genetics_GWAS	hsa-mir-146	Colorectal Carcinoma	23898084	"The current study provides evidence that the miR-146a rs2690164 polymorphism, as the dominant model of the G allele, is associated with the susceptibility and prognosis of CRC."
genetics_GWAS	hsa-mir-182	Hyperactivity Disorder	23906647	Evaluation of single nucleotide polymorphisms in the miR-183-96-182 cluster in adulthood attention-deficit and hyperactivity disorder (ADHD) and substance use disorders (SUDs).
genetics_GWAS	hsa-mir-183	Hyperactivity Disorder	23906647	Evaluation of single nucleotide polymorphisms in the miR-183-96-182 cluster in adulthood attention-deficit and hyperactivity disorder (ADHD) and substance use disorders (SUDs).
genetics_GWAS	hsa-mir-96	Hyperactivity Disorder	23906647	Evaluation of single nucleotide polymorphisms in the miR-183-96-182 cluster in adulthood attention-deficit and hyperactivity disorder (ADHD) and substance use disorders (SUDs).
genetics_GWAS	hsa-mir-34b	"Carcinoma, Hepatocellular"	23935875	Lack of association of MiR-34b/c polymorphism (rs4938723) with hepatocellular carcinoma: a meta-analysis.
genetics_GWAS	hsa-mir-31	Hypertension	23943853	Human angiotensinogen +11525 C/A polymorphism modulates its gene expression through microRNA binding.
genetics_GWAS	hsa-mir-584	Hypertension	23943853	Human angiotensinogen +11525 C/A polymorphism modulates its gene expression through microRNA binding.
genetics_GWAS	hsa-mir-27a	Breast Neoplasms	23954879	A genetic variant in pre-miR-27a is associated with a reduced breast cancer risk in younger Chinese population.
genetics_GWAS	hsa-mir-146a	Gastric Neoplasms	23975664	Prognostic role of microRNA polymorphisms in advanced gastric cancer: a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO).
genetics_GWAS	hsa-mir-196a-2	Gastric Neoplasms	23975664	Prognostic role of microRNA polymorphisms in advanced gastric cancer: a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO).
genetics_GWAS	hsa-mir-219-1	Gastric Neoplasms	23975664	Prognostic role of microRNA polymorphisms in advanced gastric cancer: a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO).
genetics_GWAS	hsa-mir-26a-1	Gastric Neoplasms	23975664	Prognostic role of microRNA polymorphisms in advanced gastric cancer: a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO).
genetics_GWAS	hsa-mir-27a	Gastric Neoplasms	23975664	Prognostic role of microRNA polymorphisms in advanced gastric cancer: a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO).
genetics_GWAS	hsa-mir-423	Gastric Neoplasms	23975664	Prognostic role of microRNA polymorphisms in advanced gastric cancer: a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO).
genetics_GWAS	hsa-mir-196a-2	Breast Neoplasms	23982873	"the current meta-analysis supports that the miR-196a-2 rs11614913*T, miR-499 rs3746444*T, miR-605 rs2043556*A, and miR-27a rs895919*C alleles might be protective factors for breast cancer"
genetics_GWAS	hsa-mir-27a	Breast Neoplasms	23982873	"the current meta-analysis supports that the miR-196a-2 rs11614913*T, miR-499 rs3746444*T, miR-605 rs2043556*A, and miR-27a rs895919*C alleles might be protective factors for breast cancer"
genetics_GWAS	hsa-mir-499	Breast Neoplasms	23982873	"the current meta-analysis supports that the miR-196a-2 rs11614913*T, miR-499 rs3746444*T, miR-605 rs2043556*A, and miR-27a rs895919*C alleles might be protective factors for breast cancer"
genetics_GWAS	hsa-mir-605	Breast Neoplasms	23982873	"the current meta-analysis supports that the miR-196a-2 rs11614913*T, miR-499 rs3746444*T, miR-605 rs2043556*A, and miR-27a rs895919*C alleles might be protective factors for breast cancer"
genetics_GWAS	hsa-mir-146a	Breast Neoplasms	24039706	"This meta-analysis demonstrates the compelling evidence that the rs11614913 CC genotype in miR-196a2 increases breast cancer risk, which provides useful information for the early diagnosis and prevention of breast cancer."
genetics_GWAS	hsa-mir-196a	Breast Neoplasms	24039706	"This meta-analysis demonstrates the compelling evidence that the rs11614913 CC genotype in miR-196a2 increases breast cancer risk, which provides useful information for the early diagnosis and prevention of breast cancer."
genetics_GWAS	hsa-mir-499	Breast Neoplasms	24039706	"This meta-analysis demonstrates the compelling evidence that the rs11614913 CC genotype in miR-196a2 increases breast cancer risk, which provides useful information for the early diagnosis and prevention of breast cancer."
genetics_GWAS	hsa-mir-149	"Carcinoma, Hepatocellular"	24040059	Results of this meta-analysis suggest that the hsa-miR-149 rs2292832 polymorphism is not associated with cancer risk in spite of the potentially protective role of C allele in hepatocellular carcinoma and male gastric cancer.
genetics_GWAS	hsa-mir-21	Bladder Neoplasms	24078506	"In accordance to the observed similarity between TGF-¦Â variants and miR-21 gene expression alterations in bladder tumors, treating 5637 bladder cancer cell line with TGF-¦Â recombinant protein caused a significant upregulation of miR-21. The later finding further confirmed a correlated expression of TGF-¦Âand miR-21 in bladder tumors."
genetics_GWAS	hsa-mir-499	Neoplasms [unspecific]	24085457	The miR-499 rs3746444 polymorphism is associated with an increased cancer risk.
genetics_GWAS	hsa-mir-499	Gastric Neoplasms	24107911	The rs3746444 (A>G) SNP is not associated with susceptibility to GC in the Chinese population.
genetics_GWAS	hsa-mir-218	"Carcinoma, Hepatocellular"	24118778	"rs11134527 may be a novel genetic risk factor of HCC in HBV-exposed subjects, can facilitate HBV preS deletion generation and predispose the host to the effect of T1674C/G and preS1 start codon mutation in hepatocarcinogenesis."
genetics_GWAS	hsa-mir-137	Schizophrenia	24132022	Impact of the genome-wide schizophrenia risk single nucleotide polymorphism (rs1625579) in miR-137 on brain structures in healthy individuals.
genetics_GWAS	hsa-mir-146a	Colorectal Carcinoma	24136745	Association between microRNA genetic variants and susceptibility to colorectal cancer in Chinese population.
genetics_GWAS	hsa-mir-184	Cataract	24138095	"C.57 C > T Mutation in MIR 184 is Responsible for Congenital Cataracts and Corneal Abnormalities in a Five-generation Family from Galicia, Spain."
genetics_GWAS	hsa-mir-146a	Lung Neoplasms	24144839	"These findings suggest that the rs2910164C>G in pre-miR-146a may contribute to genetic susceptibility to lung cancer, and that miR-146a might be involved in lung cancer development."
genetics_GWAS	hsa-mir-502	"Carcinoma, Lung, Non-Small-Cell"	24146953	Our data suggested that the rs16917496 T>C located at miR-502 binding site contributes to NSCLC survival by altering SET8 expression through modulating miRNA-target interaction.
genetics_GWAS	hsa-mir-561	"Carcinoma, Breast"	24166930	Genetic variant rs16430 6bp > 0bp at the microRNA-binding site in TYMS and risk of sporadic breast cancer risk in non-Hispanic white women aged ¡Ü 55 years.
genetics_GWAS	hsa-mir-423	"Squamous Cell Carcinoma, Esophageal"	24205249	MicroRNA polymorphisms and environmental smoke exposure as risk factors for oesophageal squamous cell carcinoma.
genetics_GWAS	hsa-mir-27a	"Carcinoma, Lung, Non-Small-Cell"	24223174	Our results suggest that the pre-miR-27a rs895819 polymorphism may influence NSCLC patients' clinical outcome. Further large sample studies should be used to validate our findings.
genetics_GWAS	hsa-mir-146a	"Carcinoma, Lung"	24246082	The rs2910164 C allele in pre-miR-146a and rs11614913 C allele in pre-miR-196a2 were associated with increased genetic damage levels in coke oven workers
genetics_GWAS	hsa-mir-196a-2	"Carcinoma, Lung"	24246082	The rs2910164 C allele in pre-miR-146a and rs11614913 C allele in pre-miR-196a2 were associated with increased genetic damage levels in coke oven workers
genetics_GWAS	hsa-mir-146a	Digestive System Neoplasms	24247819	miR-146a gene polymorphism rs2910164 and the risk of digestive tumors: A meta-analysis of 21 case-control studies.
genetics_GWAS	hsa-mir-196a-2	Chronic Hepatitis B	24248733	MicroRNA-196A-2 polymorphisms and hepatocellular carcinoma in patients with chronic hepatitis B.
genetics_GWAS	hsa-mir-499	Neoplasms [unspecific]	24258110	Quantitative assessment of the association between microRNA-499 rs3746444 A/G polymorphism and cancer risk.
genetics_GWAS	hsa-mir-34b	"Carcinoma, Esophageal"	24260422	Hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
genetics_GWAS	hsa-mir-34c	"Carcinoma, Esophageal"	24260422	Hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
genetics_GWAS	hsa-mir-423	"Carcinoma, Esophageal"	24260422	Hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
genetics_GWAS	hsa-mir-146a	Neoplasms [unspecific]	24278149	Association between microRNA polymorphisms and cancer risk based on the findings of 66 case-control studies.
genetics_GWAS	hsa-mir-149	Neoplasms [unspecific]	24278149	Association between microRNA polymorphisms and cancer risk based on the findings of 66 case-control studies.
genetics_GWAS	hsa-mir-196a-2	Neoplasms [unspecific]	24278149	Association between microRNA polymorphisms and cancer risk based on the findings of 66 case-control studies.
genetics_GWAS	hsa-mir-499	Neoplasms [unspecific]	24278149	Association between microRNA polymorphisms and cancer risk based on the findings of 66 case-control studies.
genetics_GWAS	hsa-mir-100	"Squamous Cell Carcinoma, Esophageal"	24288122	"Taken together, these findings indicate that miRNA polymorphisms may predict prognosis in advanced ESCC patients receiving platinum-based chemotherapy."
genetics_GWAS	hsa-mir-125a	"Squamous Cell Carcinoma, Esophageal"	24288122	"Taken together, these findings indicate that miRNA polymorphisms may predict prognosis in advanced ESCC patients receiving platinum-based chemotherapy."
genetics_GWAS	hsa-mir-146a	"Squamous Cell Carcinoma, Esophageal"	24288122	"Taken together, these findings indicate that miRNA polymorphisms may predict prognosis in advanced ESCC patients receiving platinum-based chemotherapy."
genetics_GWAS	hsa-mir-196a-2	"Squamous Cell Carcinoma, Esophageal"	24288122	"Taken together, these findings indicate that miRNA polymorphisms may predict prognosis in advanced ESCC patients receiving platinum-based chemotherapy."
genetics_GWAS	hsa-mir-26a-1	"Squamous Cell Carcinoma, Esophageal"	24288122	"Taken together, these findings indicate that miRNA polymorphisms may predict prognosis in advanced ESCC patients receiving platinum-based chemotherapy."
genetics_GWAS	hsa-mir-34b	Oral Neoplasms	24297336	Genetic variations at microRNA and processing genes and risk of oral cancer.
genetics_GWAS	hsa-mir-499	"Carcinoma, Hepatocellular"	24301908	miR-499A>G rs3746444 and miR-146aG>C expression and hepatocellular carcinoma risk in the Chinese population.
genetics_GWAS	hsa-mir-27b	Bladder Neoplasms	24312312	"Taken together, these findings suggested that DROSHA rs10719T>C polymorphism may be associated with bladder cancer risk in a Chinese population, and hsa-miR-27b can influence the expression of DROSHA protein by binding with 3'UTR."
genetics_GWAS	hsa-mir-196a-2	"Squamous Cell Carcinoma, Esophageal"	24320161	These results suggest that the miRNA-196a2 functional polymorphism rs11614913 might be an effective genetic marker for ESCC risk assessment in individuals younger than 60 years of age from a region of high ESCC incidence in northern China.
genetics_GWAS	hsa-mir-499	Rheumatoid Arthritis	24327058	This study suggested that miR-499 polymorphisms were associated with a significantly increased risk of RA in Mediterranean populations.
genetics_GWAS	hsa-mir-21	"Squamous Cell Carcinoma, Head and Neck"	24327270	"CLU is a specific, functional target of oncogenic miRNA-21 in HNSCCs. CLU-1 isoform is the predominant growth-suppressive variant targeted by miRNA-21."
genetics_GWAS	hsa-mir-34b	Colorectal Carcinoma	24337371	Polymorphisms of the pri-miR-34b/c promoter and TP53 codon 72 are associated with risk of colorectal cancer.
genetics_GWAS	hsa-mir-34c	Colorectal Carcinoma	24337371	Polymorphisms of the pri-miR-34b/c promoter and TP53 codon 72 are associated with risk of colorectal cancer.
genetics_GWAS	hsa-mir-125b	Endometriosis	24339876	Genetic variation at the miR-125b binding site may play functional roles to protect against endometriosis progression.
genetics_GWAS	hsa-mir-502	"Carcinoma, Lung, Non-Small-Cell"	24374662	Association of miR-502-binding site single nucleotide polymorphism in the 3'-untranslated region of SET8 and TP53 codon 72 polymorphism with non-small cell lung cancer in Chinese population.
genetics_GWAS	hsa-mir-146a	"Carcinoma, Hepatocellular"	24377574	"Our results demonstrate that miR-196a4 CC genotype and C allele have an important role in HCC risk in Chinese, especially in patients with HBV infection."
genetics_GWAS	hsa-mir-196a	"Carcinoma, Hepatocellular"	24377574	"Our results demonstrate that miR-196a2 CC genotype and C allele have an important role in HCC risk in Chinese, especially in patients with HBV infection."
genetics_GWAS	hsa-mir-499	"Carcinoma, Hepatocellular"	24377574	"Our results demonstrate that miR-196a3 CC genotype and C allele have an important role in HCC risk in Chinese, especially in patients with HBV infection."
genetics_GWAS	hsa-mir-146a	Gastric Neoplasms	24379078	"Association of the miR-146aC>G, miR-149T>C, and miR-196a2T>C polymorphisms with gastric cancer risk and survival in the Greek population."
genetics_GWAS	hsa-mir-149	Gastric Neoplasms	24379078	"Association of the miR-146aC>G, miR-149T>C, and miR-196a2T>C polymorphisms with gastric cancer risk and survival in the Greek population."
genetics_GWAS	hsa-mir-196a-2	Gastric Neoplasms	24379078	"Association of the miR-146aC>G, miR-149T>C, and miR-196a2T>C polymorphisms with gastric cancer risk and survival in the Greek population."
genetics_GWAS	hsa-mir-27a	"Carcinoma, Cervical"	24380734	A genetic variant in pre-miR-27a is associated with a reduced cervical cancer risk in southern Chinese women.
genetics_GWAS	hsa-mir-485	Hyperglycemia	24387992	An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site.
genetics_GWAS	hsa-mir-146a	Colorectal Carcinoma	24399071	Effects of common polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on susceptibility to colorectal cancer: a systematic review meta-analysis.
genetics_GWAS	hsa-mir-196a-2	Colorectal Carcinoma	24399071	Effects of common polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on susceptibility to colorectal cancer: a systematic review meta-analysis.
genetics_GWAS	hsa-mir-106b	"Carcinoma, Hepatocellular"	24416400	A genetic variant in the promoter region of miR-106b-25 cluster predict clinical outcome of HBV-related hepatocellular carcinoma in Chinese.
genetics_GWAS	hsa-mir-330	Psychiatric Disorders	24436253	The effects of a MAP2K5 microRNA target site SNP on risk for anxiety and depressive disorders.
genetics_GWAS	hsa-mir-146	Coronary Artery Disease	24447667	A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression.
genetics_GWAS	hsa-mir-135b	"Carcinoma, Cervical"	24465869	Genetic variants in microRNA target sites of 37 selected cancer-related genes and the risk of cervical cancer.
genetics_GWAS	hsa-mir-101-1	Breast Neoplasms	24475105	Genetic variations in the flanking regions of miR-101-2 are associated with increased risk of breast cancer.
genetics_GWAS	hsa-mir-101-2	Breast Neoplasms	24475105	Genetic variations in the flanking regions of miR-101-2 are associated with increased risk of breast cancer.
genetics_GWAS	hsa-mir-146a	Immune Thrombocytopenic Purpura	24502829	hsa-mir-146a rs2910164 polymorphism and risk of immune thrombocytopenia.
genetics_GWAS	hsa-mir-34b	"Carcinoma, Renal Cell"	24503183	A potentially functional polymorphism in the promoter region of miR-34b/c is associated with renal cell cancer risk in a Chinese population.
genetics_GWAS	hsa-mir-34c	"Carcinoma, Renal Cell"	24503183	A potentially functional polymorphism in the promoter region of miR-34b/c is associated with renal cell cancer risk in a Chinese population.
genetics_GWAS	hsa-mir-499	Breast Neoplasms	24521023	Our findings demonstrated that the hsa-mir-499 rs3746444 polymorphism is associated with higher risk of developing breast cancer in our population.
genetics_GWAS	hsa-mir-146a	Gastric Neoplasms	24528016	A genetic variant in MiR-146a modifies digestive system cancer risk: a meta-analysis.
genetics_GWAS	hsa-mir-146a	Colorectal Carcinoma	24568449	These findings supported that the miR-196a2 rs11614913 and miR-149 rs2292832 polymorphisms may contribute to susceptibility to CRC.
genetics_GWAS	hsa-mir-149	Colorectal Carcinoma	24568449	These findings supported that the miR-196a2 rs11614913 and miR-149 rs2292832 polymorphisms may contribute to susceptibility to CRC.
genetics_GWAS	hsa-mir-196a	Colorectal Carcinoma	24568449	These findings supported that the miR-196a2 rs11614913 and miR-149 rs2292832 polymorphisms may contribute to susceptibility to CRC.
genetics_GWAS	hsa-mir-499	Colorectal Carcinoma	24568449	These findings supported that the miR-196a2 rs11614913 and miR-149 rs2292832 polymorphisms may contribute to susceptibility to CRC.
genetics_GWAS	hsa-mir-624	Gastric Neoplasms	24568522	Bioinformatic prediction of SNPs within miRNA binding sites of inflammatory genes associated with gastric cancer.
genetics_GWAS	hsa-mir-146a	Alzheimer Disease	24586483	A functional polymorphism in the promoter region of microRNA-146a is associated with the risk of Alzheimer disease and the rate of cognitive decline in patients.
genetics_GWAS	hsa-mir-146a	"Carcinoma, Hepatocellular"	24587132	"These results suggest that a significant association exists between miRNA499 SNPs and hepatocellular carcinoma. Gene-environment interactions of miRNA499 polymorphisms, smoking, and alcohol consumption might alter hepatocellular carcinoma susceptibility."
genetics_GWAS	hsa-mir-149	"Carcinoma, Hepatocellular"	24587132	"These results suggest that a significant association exists between miRNA499 SNPs and hepatocellular carcinoma. Gene-environment interactions of miRNA499 polymorphisms, smoking, and alcohol consumption might alter hepatocellular carcinoma susceptibility."
genetics_GWAS	hsa-mir-196	"Carcinoma, Hepatocellular"	24587132	"These results suggest that a significant association exists between miRNA499 SNPs and hepatocellular carcinoma. Gene-environment interactions of miRNA499 polymorphisms, smoking, and alcohol consumption might alter hepatocellular carcinoma susceptibility."
genetics_GWAS	hsa-mir-499	"Carcinoma, Hepatocellular"	24587132	"These results suggest that a significant association exists between miRNA499 SNPs and hepatocellular carcinoma. Gene-environment interactions of miRNA499 polymorphisms, smoking, and alcohol consumption might alter hepatocellular carcinoma susceptibility."
genetics_GWAS	hsa-mir-124	"Carcinoma, Cervical"	24589598	"miR-124 rs531564 polymorphism may play a role in cervical cancer susceptibility in Chinese Han women, and G allele is associated with a reduced risk of cervical cancer."
genetics_GWAS	hsa-mir-526b	"Carcinoma, Gastric"	24595048	The has-miR-526b binding-site rs8506G>a polymorphism in the lincRNA-NR_024015 exon identified by GWASs predispose to non-cardia gastric cancer risk.
genetics_GWAS	hsa-mir-3649	Non-Syndromic Orofacial Clefts	24603642	"Taken together, these findings indicate that SNPs in the miRNA-binding sites might play an important role in the development of NSOCs. Furthermore, if confirmed in subsequent studies, the polymorphisms may be considered as additional markers for the evaluation of infants' risk of NSOCs."
genetics_GWAS	hsa-mir-146a	"Carcinoma, Hepatocellular"	24615520	miR-146a G>C polymorphisms and risk of hepatocellular carcinoma in a Chinese population.
genetics_GWAS	hsa-mir-499	"Leukemia, Lymphoblastic, Acute"	24618566	"We found 11 SNPs significantly associated with ALL susceptibility. These included three SNPs present in miRNA genes (miR-612, miR-499, and miR-449b) and eight SNPs present in six miRNA biogenesis pathway genes (TNRC6B, DROSHA, DGCR8, EIF2C1, CNOT1, and CNOT6)."
genetics_GWAS	hsa-mir-146a	Alcohol Use Disorder	24630744	This is the first genetic association study to explore the relationship of miRNA polymorphisms with AUDs and to show an association of the miR-146a C>G rs2910164 allelic variant with this disease.
genetics_GWAS	hsa-mir-196a-2	Liver Neoplasms	24633889	"Quantitative assessment of the association between miR-196a2 rs11614913 polymorphism and cancer risk: evidence based on 45,816 subjects."
genetics_GWAS	hsa-mir-2278	Multiple Sclerosis	24638856	Assessment of microRNA-related SNP effects in the 3' untranslated region of the IL22RA2 risk locus in multiple sclerosis.
genetics_GWAS	hsa-mir-411	Multiple Sclerosis	24638856	Assessment of microRNA-related SNP effects in the 3' untranslated region of the IL22RA2 risk locus in multiple sclerosis.
genetics_GWAS	hsa-mir-146a	Uveitis	24658012	This study shows that miR-146a and Ets-1 are both associated with pediatric uveitis in Han Chinese. SNP rs10893872 may affect the genetic predisposition to pediatric uveitis by modulating expression of Ets-1.
genetics_GWAS	hsa-mir-4436b-1	Autism Spectrum Disorder	24667286	Assessing the impact of copy number variants on miRNA genes in autism by Monte Carlo simulation.
genetics_GWAS	hsa-mir-4436b-2	Autism Spectrum Disorder	24667286	Assessing the impact of copy number variants on miRNA genes in autism by Monte Carlo simulation.
genetics_GWAS	hsa-mir-424	Myelodysplastic Syndromes	24674452	Detection of an activated JAK3 variant and a Xq26.3 microdeletion causing loss of PHF6 and miR-424 expression in myelodysplastic syndromes by combined targeted next generation sequencing and SNP array analysis.
genetics_GWAS	hsa-mir-224	Coronary Artery Disease	24676100	Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.
genetics_GWAS	hsa-mir-149	"Carcinoma, Renal Cell"	24681820	"We genotyped four common miRNA SNPs (i.e. miR-146a rs2910164, miR-149 rs2292832, miR-196a2 rs11614913 and miR-499 rs3746444) to assess their associations with RCC risk in a two-stage case-control study (355 cases and 362 controls in discovery set, meanwhile 647 cases and 660 controls in validation set), as well as RCC survival in 311 patients."
genetics_GWAS	hsa-mir-518	Hypertension	24687999	Our results suggest that TGFBR2 and miR-518 harbor variants that increase the risk of EH and affect blood pressure homeostasis as well as efficacy of antihypertensive agents.
genetics_GWAS	hsa-mir-146a	Skin Neoplasms	24699816	"we investigated the impact of MIR146A SNP rs2910164 on cancer risk, and interaction with a SNP in one of its putative targets (RNASEL, rs486907)."
genetics_GWAS	hsa-mir-146a	Sepsis	24701036	The functional polymorphisms of miR-146a are associated with susceptibility to severe sepsis in the Chinese population.
genetics_GWAS	hsa-mir-146a	Dermatomyositis	24716199	MIRSNP rs2910164 of miR-146a is associated with the muscle involvement in polymyositis/dermatomyositis.
genetics_GWAS	hsa-mir-146a	Neoplasms [unspecific]	24716941	Association analysis of single nucleotide polymorphisms in miR-146a and miR-196a2 on the prevalence of cancer in elderly Japanese: a case-control study.
genetics_GWAS	hsa-mir-196a-2	Neoplasms [unspecific]	24716941	Association analysis of single nucleotide polymorphisms in miR-146a and miR-196a2 on the prevalence of cancer in elderly Japanese: a case-control study.
genetics_GWAS	hsa-mir-142	"Leukemia, Myeloid, Acute"	24724784	Absence of miR-142 mutation in Chinese patients with acute myeloid leukemia.
genetics_GWAS	hsa-let-7	"Carcinoma, Colon"	24727325	"In the largest association study investigating the LCS6 polymorphism in colon cancers, the germline LCS6 genotype was not associated with KRAS mutation status or with clinical outcome in patients with stage III tumors."
genetics_GWAS	hsa-let-7	Hepatitis B Virus Infection	24729511	Association of a functional RAD52 genetic variant locating in a miRNA binding site with risk of HBV-related hepatocellular carcinoma.
genetics_GWAS	hsa-mir-146a	Colorectal Carcinoma	24740563	Association of a genetic variant in microRNA-146a with risk of colorectal cancer: a population-based case-control study.
genetics_GWAS	hsa-mir-378	"Carcinoma, Hepatocellular"	24751683	These findings indicate that rs1076064 may be a biomarker for HCC susceptibility and prognosis through altering pri-miR-378 transcription.
genetics_GWAS	hsa-mir-143	Congenital Heart Diseases	24752771	No association of pri-miR-143 rs41291957 polymorphism with the risk of congenital heart disease in a Chinese population.
genetics_GWAS	hsa-let-7a	Gastric Neoplasms	24760009	"pri-let-7a-2 rs629367 CC genotype could increase the risks of gastric cancer as well as atrophic gastritis and was also associated with poor survival of gastric cancer, which possibly by affecting the mature let-7a expression, and could serve as a predicting biomarker for high-risk and poor prognosis of gastric cancer."
genetics_GWAS	hsa-mir-218	Neoplasms [unspecific]	24761857	"The findings suggest that pre-miR-218 rs11134527 polymorphism may have some relation to cancer development in Chinese. However, well-designed studies with larger sample size and more detailed data are needed to confirm these conclusions."
genetics_GWAS	hsa-mir-608	"Squamous Cell Carcinoma, Esophageal"	24770678	"The hereditary genetic polymorphisms of mir-608, RAN, and GEMIN4 can serve as predictors for clinical outcome in ESCC patients treated with concurrent chemoradiotherapy."
genetics_GWAS	hsa-mir-146a	IgA Nephropathy	24781267	These results indicated that rs2910164 may affect the susceptibility and severity of pediatric IgAN. Further studies are needed to validate these findings.
genetics_GWAS	hsa-mir-182	Behcet Disease	24801147	Predisposition to Behcet's disease and VKH syndrome by genetic variants of miR-182.
genetics_GWAS	hsa-mir-146a	Systemic Lupus Erythematosus	24803388	Association of miR-146a polymorphisms with systemic lupus erythematosus: a meta-analysis.
genetics_GWAS	hsa-mir-26b	Obesity	24807789	"Expression of microRNA-26b, an obesity-related microRNA, is regulated by free fatty acids, glucose, dexamethasone and growth hormone in human adipocytes."
genetics_GWAS	hsa-mir-146a	"Carcinoma, Hepatocellular"	24816919	Association between miR-146aG>C and miR-196a2C>T polymorphisms and the risk of hepatocellular carcinoma in a Chinese population.
genetics_GWAS	hsa-mir-196a-2	"Carcinoma, Hepatocellular"	24816919	Association between miR-146aG>C and miR-196a2C>T polymorphisms and the risk of hepatocellular carcinoma in a Chinese population.
genetics_GWAS	hsa-mir-499	"Carcinoma, Hepatocellular"	24816919	Association between miR-146aG>C and miR-196a2C>T polymorphisms and the risk of hepatocellular carcinoma in a Chinese population.
genetics_GWAS	hsa-mir-146a	Rheumatoid Arthritis	24824381	Association of two polymorphisms rs2910164 in miRNA-146a and rs3746444 in miRNA-499 with rheumatoid arthritis: a meta-analysis.
genetics_GWAS	hsa-mir-499	Rheumatoid Arthritis	24824381	Association of two polymorphisms rs2910164 in miRNA-146a and rs3746444 in miRNA-499 with rheumatoid arthritis: a meta-analysis.
genetics_GWAS	hsa-mir-33b	Hyperglycemia	24825092	Association of rs8066560 variant in the sterol regulatory element-binding protein 1 (SREBP-1) and miR-33b genes with hyperglycemia and insulin resistance.
genetics_GWAS	hsa-mir-146a	Myocardial Infarction	24850191	Association of microRNA polymorphisms with the risk of myocardial infarction in a Chinese population.
genetics_GWAS	hsa-mir-149	Myocardial Infarction	24850191	Association of microRNA polymorphisms with the risk of myocardial infarction in a Chinese population.
genetics_GWAS	hsa-mir-196a-2	Myocardial Infarction	24850191	Association of microRNA polymorphisms with the risk of myocardial infarction in a Chinese population.
genetics_GWAS	hsa-mir-218	Myocardial Infarction	24850191	Association of microRNA polymorphisms with the risk of myocardial infarction in a Chinese population.
genetics_GWAS	hsa-mir-499	Myocardial Infarction	24850191	Association of microRNA polymorphisms with the risk of myocardial infarction in a Chinese population.
genetics_GWAS	hsa-mir-196a-2	"Carcinoma, Lung, Non-Small-Cell"	24853117	"Importantly, this method can be further applied to analyze the point mutation of mir-196a2 in the lung tissues of non small-cell lung cancer patients."
genetics_GWAS	hsa-mir-499	"Carcinoma, Hepatocellular"	24854593	"miR-499 rs3746444 may contribute to the risk and prognosis of HCC, indicating that this SNP could be developed as a biomarker for HCC prediction."
genetics_GWAS	hsa-mir-29a	Oral Neoplasms	24885463	Variations in microRNAs and their processing genes modulated risk of precancer but further in-depth study is needed to understand mechanism of disease process.
genetics_GWAS	hsa-mir-34b	Oral Neoplasms	24885463	Variations in microRNAs and their processing genes modulated risk of precancer but further in-depth study is needed to understand mechanism of disease process.
genetics_GWAS	hsa-mir-423	Oral Neoplasms	24885463	Variations in microRNAs and their processing genes modulated risk of precancer but further in-depth study is needed to understand mechanism of disease process.
genetics_GWAS	hsa-mir-34c	"Leukemia, Myeloid"	24886876	Our study implicates that microRNA-binding site polymorphisms modulate leukemia risk by interfering with the miRNA-mediated regulation. Our findings underscore the significance of variability in 3' untranslated regions in leukemia.
genetics_GWAS	hsa-mir-449b	"Leukemia, Myeloid"	24886876	Our study implicates that microRNA-binding site polymorphisms modulate leukemia risk by interfering with the miRNA-mediated regulation. Our findings underscore the significance of variability in 3' untranslated regions in leukemia.
genetics_GWAS	hsa-let-7	Colorectal Carcinoma	24890702	Let-7 microRNA-binding-site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta-analysis.
genetics_GWAS	hsa-mir-196a	Breast Neoplasms	24922658	The current study provides evidence that the miR-196a rs11614913T>C polymorphisms are possible prognostic biomarker for patients with hormone receptor-expressing early breast cancer.
genetics_GWAS	hsa-mir-603	Colorectal Carcinoma	24934365	"Our data suggest that hsa-miR-603 may be involved in colorectal tumorigenesis, and the genetic polymorphism in hsa-miR-603 is associated with CRC susceptibility."
genetics_GWAS	hsa-mir-124	"Squamous Cell Carcinoma, Esophageal"	24945256	Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.
genetics_GWAS	hsa-mir-34b	"Squamous Cell Carcinoma, Esophageal"	24945256	Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.
genetics_GWAS	hsa-mir-34c	"Squamous Cell Carcinoma, Esophageal"	24945256	Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.
genetics_GWAS	hsa-mir-146a	"Stroke, Ischemic"	24952884	miR-146a and miR-196a2 polymorphisms in patients with ischemic stroke in the northern Chinese Han population.
genetics_GWAS	hsa-mir-196a-2	"Stroke, Ischemic"	24952884	miR-146a and miR-196a2 polymorphisms in patients with ischemic stroke in the northern Chinese Han population.
genetics_GWAS	hsa-mir-196a-2	"Diabetes Mellitus, Type 2"	24972764	Our findings suggest that miRNA-196a2 T/C polymorphism (rs11614913) is associated with an increased risk of CVD in type 2 diabetes patients. This provides further insights on pathogenesis of cardiovascular disease in type 2 diabetes patients.
genetics_GWAS	hsa-mir-132	Gastric Neoplasms	24981235	"A functional variant at miR-132-3p, miR-212-3p, and miR-361-5p binding site in CD80 gene alters susceptibility to gastric cancer in a Chinese Han population."
genetics_GWAS	hsa-mir-212	Gastric Neoplasms	24981235	"A functional variant at miR-132-3p, miR-212-3p, and miR-361-5p binding site in CD80 gene alters susceptibility to gastric cancer in a Chinese Han population."
genetics_GWAS	hsa-mir-361	Gastric Neoplasms	24981235	"A functional variant at miR-132-3p, miR-212-3p, and miR-361-5p binding site in CD80 gene alters susceptibility to gastric cancer in a Chinese Han population."
genetics_GWAS	hsa-mir-410	Stroke	24990426	"We report a novel association between a microRNA target site variant and stroke incidence, which is modulated by diet in terms of decreasing triglycerides and possibly stroke risk in rs13702 C allele carriers after a high-unsaturated fat MedDiet intervention."
genetics_GWAS	hsa-mir-125a	Autoimmune Thyroiditis	24990808	Associations of single nucleotide polymorphisms in precursor-microRNA (miR)-125a and the expression of mature miR-125a with the development and prognosis of autoimmune thyroid diseases.
genetics_GWAS	hsa-mir-122	"Carcinoma, Hepatocellular"	24995424	A genetic variant in microRNA-122 regulatory region confers risk for chronic hepatitis B virus infection and hepatocellular carcinoma in Han Chinese.
genetics_GWAS	hsa-mir-485	Breast Neoplasms	25003827	miR-485-5p binding site SNP rs8752 in HPGD gene is associated with breast cancer risk.
genetics_GWAS	hsa-mir-137	Schizophrenia	25044277	The miR-137 schizophrenia susceptibility variant rs1625579 does not predict variability in brain volume in a sample of schizophrenic patients and healthy individuals.
genetics_GWAS	hsa-mir-146a	Coronary Restenosis	25053223	we found a negative association for the G/C (P = 0.007) and a positive association for the C/C genotype with the risk of restenosis
genetics_GWAS	hsa-mir-149	"Carcinoma, Hepatocellular"	25061729	Association of miR-149C>T and miR-500A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population.
genetics_GWAS	hsa-mir-499a	"Carcinoma, Hepatocellular"	25061729	Association of miR-149C>T and miR-499A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population.
genetics_GWAS	hsa-mir-26a	Neurodegenerative Diseases [unspecific]	25074322	A functional SNP catalog of overlapping miRNA-binding sites in genes implicated in prion disease and other neurodegenerative disorders.
genetics_GWAS	hsa-mir-146a	Lung Neoplasms	25077922	Effects of four single nucleotide polymorphisms in microRNA-coding genes on lung cancer risk.
genetics_GWAS	hsa-mir-149	Lung Neoplasms	25077922	Effects of four single nucleotide polymorphisms in microRNA-coding genes on lung cancer risk.
genetics_GWAS	hsa-mir-196a-2	Lung Neoplasms	25077922	Effects of four single nucleotide polymorphisms in microRNA-coding genes on lung cancer risk.
genetics_GWAS	hsa-mir-499b	Lung Neoplasms	25077922	Effects of four single nucleotide polymorphisms in microRNA-coding genes on lung cancer risk.
genetics_GWAS	hsa-mir-27a	Colorectal Carcinoma	25078482	Association between miR-27a genetic variants and susceptibility to colorectal cancer.
genetics_GWAS	hsa-mir-146a	Prostate Neoplasms	25084752	Association between genetic variant in hsa-miR-146a gene and prostate cancer progression
genetics_GWAS	hsa-mir-146a	Colorectal Carcinoma	25103961	"Lack of association between miR-27a, miR-146a, miR-196a-2, miR-492 and miR-608 gene polymorphisms and colorectal cancer."
genetics_GWAS	hsa-mir-196a-2	Colorectal Carcinoma	25103961	"Lack of association between miR-27a, miR-146a, miR-196a-2, miR-492 and miR-608 gene polymorphisms and colorectal cancer."
genetics_GWAS	hsa-mir-27a	Colorectal Carcinoma	25103961	"Lack of association between miR-27a, miR-146a, miR-196a-2, miR-492 and miR-608 gene polymorphisms and colorectal cancer."
genetics_GWAS	hsa-mir-125a	Gastric Neoplasms	25109760	"In this study, we found that a germline mutation in the miR-125a coding region is associated with human gastric cancer."
genetics_GWAS	hsa-mir-146a	Lung Neoplasms	25154761	MicroRNA-146a rs2910164 polymorphism is associated with susceptibility to non-small cell lung cancer in the Chinese population.
genetics_GWAS	hsa-mir-502	"Carcinoma, Cervical"	25169478	"These data suggest that there are significant associations between the miR-502-binding site SNP in the 3'-UTR of SET8 and the TP53 codon 72 polymorphism with cervical cancer in Chinese, and there is a gene-gene interaction."
genetics_GWAS	hsa-mir-646	"Carcinoma, Hepatocellular"	25177719	Our findings support the view that the miR-646 SNP rs6513497 may contribute to the susceptibility of HCC.
genetics_GWAS	hsa-mir-34a	"Carcinoma, Hepatocellular"	25179842	A functional variant at miR-34a binding site in toll-like receptor 4 gene alters susceptibility to hepatocellular carcinoma in a Chinese Han population.
genetics_GWAS	hsa-mir-146a	Leprosy	25187983	Pre-miR-146a (rs2910164 G>C) single nucleotide polymorphism is genetically and functionally associated with leprosy.
genetics_GWAS	hsa-mir-34b	Neoplasms [unspecific]	25190019	The genetic association between pri-miR-34b/c polymorphism (rs4938723 T>C) and susceptibility to cancers: evidence from published studies.
genetics_GWAS	hsa-mir-34c	Neoplasms [unspecific]	25190019	The genetic association between pri-miR-34b/c polymorphism (rs4938723 T>C) and susceptibility to cancers: evidence from published studies.
genetics_GWAS	hsa-mir-34b	Gastric Neoplasms	25190020	Promoter polymorphisms of miR-34b/c are associated with risk of gastric cancer in a Chinese population.
genetics_GWAS	hsa-mir-34c	Gastric Neoplasms	25190020	Promoter polymorphisms of miR-34b/c are associated with risk of gastric cancer in a Chinese population.
genetics_GWAS	hsa-mir-1	Coronary Artery Disease	25197382	Polymorphism in miRNA-1 target site and circulating miRNA-1 phenotype are associated with the decreased risk and prognosis of coronary artery disease.
genetics_GWAS	hsa-mir-146a	Psoriasis	25209759	A single-nucleotide polymorphism of miR-146a and psoriasis: an association and functional study.
genetics_GWAS	hsa-mir-146a	Systemic Lupus Erythematosus	25218914	"The present meta-analysis suggests important roles for the mir-499 rs3746444 polymorphism in RA, especially in the Caucasian population and for miR-146a rs57095329 polymorphism in SLE."
genetics_GWAS	hsa-mir-149	"Carcinoma, Hepatocellular"	25222224	Role of miR-149C>T polymorphisms on the risk of hepatocellular carcinoma in a Chinese population.
genetics_GWAS	hsa-mir-27a	Colorectal Carcinoma	25222241	Association between a functional variant in microRNA-27a and susceptibility to colorectal cancer in a Chinese Han population.
genetics_GWAS	hsa-mir-137	Schizophrenia	25241074	Lack of association between microRNA-137 SNP rs1625579 and schizophrenia in a replication study of Han Chinese.
genetics_GWAS	hsa-mir-4513	Coronary Artery Disease	25256095	"A genetic variant in the seed region of miR-4513 shows pleiotropic effects on lipid and glucose homeostasis, blood pressure, and coronary artery disease."
genetics_GWAS	hsa-mir-146a	Arthritis	25269878	This meta-analysis suggests that the miR-499 rs374644 and IRAKI rs3027898 polymorphisms are associated with susceptibility to inflammatory arthritis.
genetics_GWAS	hsa-mir-499	Arthritis	25269878	This meta-analysis suggests that the miR-499 rs374644 and IRAKI rs3027898 polymorphisms are associated with susceptibility to inflammatory arthritis.
genetics_GWAS	hsa-mir-146a	Colorectal Carcinoma	25283877	Effect of a common genetic variant microRNA-146a rs2910164 on colorectal cancer: a meta-analysis.
genetics_GWAS	hsa-mir-146a	Generalized Epilepsy with Febrile Seizures Plus	25319229	Association of genetic polymorphism of pre-microRNA-146a rs2910164 and serum high-mobility group box 1 with febrile seizures in Egyptian children.
genetics_GWAS	hsa-mir-146a	Gastric Neoplasms	25326754	The present meta-analysis suggests an increased risk between miR-146a rs2910164 GG genotype and gastric cancer susceptibility in Chinese based on published literatures.
genetics_GWAS	hsa-mir-218	"Squamous Cell Carcinoma, Esophageal"	25337271	The impact of pri-miR-218 rs11134527 on the risk and prognosis of patients with esophageal squamous cell carcinoma.
genetics_GWAS	hsa-mir-502	"Lymphoma, Non-Hodgkin"	25343552	the SNP in the miRNA binding site of the SET8 3'-untranslated region seems to influence survival of NHL. It may have possible prognostic and survival value in the clinic.
genetics_GWAS	hsa-mir-143	Prostate Neoplasms	25354797	there is the significant association between the functional promoter variant rs4705342T>C in miR-143 and PCa risk
genetics_GWAS	hsa-mir-518	Premature Ovarian Failure	25365407	"Association study of TGFBR2 and miR-518 gene polymorphisms with age at natural menopause, premature ovarian failure, and early menopause among Chinese Hanwomen."
genetics_GWAS	hsa-mir-146a	"Lymphoma, B-Cell"	25370733	MicroRNA-146a rs2910164 polymorphism and the risk of diffuse large B cell lymphoma in the Chinese Han population.
genetics_GWAS	hsa-mir-184	"Squamous Cell Carcinoma, Esophageal"	25383966	Our data demonstrate that functional TNFAIP2 rs8126 genetic variant is a ESCC susceptibility SNP.
genetics_GWAS	hsa-mir-146a	Gastric Neoplasms	25386093	"The miR-146a rs2910164 polymorphism is associated with increased gastric cancer risk, particularly evident in high quality studies with small sample sized Caucasian populations."
genetics_GWAS	hsa-mir-27a	Gastric Neoplasms	25399405	rs895819 and rs11671784 inversely affect gastric cancer risk and the influence was closely related to their effects on miR-27a expression.
genetics_GWAS	hsa-mir-148a	Gastric Neoplasms	25399950	the SCRN1 rs6976789 polymorphism may play an important role in the GC development and progression.
genetics_GWAS	hsa-mir-149	Thyroid Neoplasms	25405731	"Rs2292832 was possibly involved in the susceptibility and local progression of PTC in Chinese patients, by altering the expression level of mir-149-5p and its target genes."
genetics_GWAS	hsa-mir-604	"Carcinoma, Hepatocellular"	25408584	"The T allele at miR-604 rs2368392 may be a risk allele for the chronicity of HBV infection, but may be a protective allele for the progression to HCC in chronic HBV carriers."
genetics_GWAS	hsa-mir-499	Neoplasms [unspecific]	25433484	"hsa-mir-499 rs3746444 T > C polymorphism is associated with the risk of cancer in Asians, mainly in Iranian and Chinese population. However, rs3746444 T > C polymorphism is negatively associated with the risk of esophageal cancer."
genetics_GWAS	hsa-mir-137	Schizophrenia	25434007	"rare noncoding risk variants are associated with SZ and BP at MIR137/MIR2682 locus, with risk alleles decreasing MIR137/MIR2682 expression."
genetics_GWAS	hsa-mir-2682	Schizophrenia	25434007	"rare noncoding risk variants are associated with SZ and BP at MIR137/MIR2682 locus, with risk alleles decreasing MIR137/MIR2682 expression."
genetics_GWAS	hsa-mir-611	Pleural Mesothelioma	25436799	MRP performance as diagnostic biomarker improved by considering the genotype rs1057147. This polymorphism most likely affects a binding site for miR-611.
genetics_GWAS	hsa-mir-146a	Hirschsprung Disease	25445498	"the polymorphism rs2910164 in pre-miR-146a might alter the production of mature miR-146a and then down-regulate the target gene ROBO1, which plays an important role in pathogenesis of HSCR."
genetics_GWAS	hsa-mir-146a	Gastric Neoplasms	25455160	"miR-146a rs2910164 polymorphism was associated with the susceptibility to gastric cancer, especially in Asian population."
genetics_GWAS	hsa-mir-34b	Colorectal Carcinoma	25475831	rs4938723 was a susceptible locus only for hepatocellular cancer and colorectal cancer.
genetics_GWAS	hsa-mir-34c	Colorectal Carcinoma	25475831	rs4938723 was a susceptible locus only for hepatocellular cancer and colorectal cancer.
genetics_GWAS	hsa-mir-196a	"Lymphoma, Non-Hodgkin"	25501512	the miR-196a2 polymorphism may increase the risk of NHL by altering the expression of mature miR-196a.
genetics_GWAS	hsa-mir-146a	Lung Neoplasms	25524943	mir-196a2 SNP influences the susceptibility of lung cancer. Mir-146a and mir-149 SNP do not play a role in lung cancer risk. These findings need more validation by larger studies.
genetics_GWAS	hsa-mir-149	Lung Neoplasms	25524943	mir-196a2 SNP influences the susceptibility of lung cancer. Mir-146a and mir-149 SNP do not play a role in lung cancer risk. These findings need more validation by larger studies.
genetics_GWAS	hsa-mir-196a-2	Lung Neoplasms	25524943	mir-196a2 SNP influences the susceptibility of lung cancer. Mir-146a and mir-149 SNP do not play a role in lung cancer risk. These findings need more validation by larger studies.
genetics_GWAS	hsa-mir-34a	Parkinson Disease	25541488	"down-regulation of miR-34b and miR-34c in the brain, as well as an SNP in the 3'-UTR of ¦Á-syn can increase ¦Á-syn expression, possibly contributing to PD pathogenesis."
genetics_GWAS	hsa-mir-146a	"Carcinoma, Hepatocellular"	25546664	"the miR-146a rs2910164 polymorphism contributes to increased HCC susceptibility, especially in Asian populations. Further large and well-designed studies are required to validate this association."
genetics_GWAS	hsa-mir-196a-2	"Carcinoma, Hepatocellular"	25546664	"the miR-146a rs2910165 polymorphism contributes to increased HCC susceptibility, especially in Asian populations. Further large and well-designed studies are required to validate this association."
genetics_GWAS	hsa-mir-146a	Digestive System Neoplasms	25555557	"digestive tract neoplasms might associate with miR-146a variants, but not miR-196a2 variants"
genetics_GWAS	hsa-mir-196a	Digestive System Neoplasms	25555557	"digestive tract neoplasms might associate with miR-146a variants, but not miR-196a2 variants"
genetics_GWAS	hsa-mir-27a	Breast Neoplasms	25556434	an association between pre-miR-27a polymorphism rs895819 and cancer risk in Caucasians. The protective effect of rs895819 [G] allele in younger breast cancer and in the group of unilateral breast cancer patients await further confirmation since the included studies in this meta-analysis were limited.
genetics_GWAS	hsa-mir-320b	Coronary Artery Disease	25573129	"The common SNP (rs10916581) in the promoter region of pre-miR-320b-2 might have little contribution to the CHD predisposition in Chinese Han population, and it might not affect circulating miR-320b level. Conventional CHD risk factors (BMI, TC/HDL-C, hypertension and diabetes) might have effects on its circulating level."
genetics_GWAS	hsa-mir-146a	Multiple Sclerosis	25591770	rs2910164 may play a role in MS susceptibility in females. The rs2910164 G>C variation may affect the expression of miR-146a and the release of proinflammatory cytokines.
genetics_GWAS	hsa-mir-499	Lung Neoplasms	25614447	"the rs3746444T>C polymorphism in mature miR-499 sequence could contribute to poor prognosis by modulating cancer-related genes' expression and thus involve tumorigenesis and anti-chemotherapy, which may be a useful biomarker to predict lung cancer patients' prognosis."
genetics_GWAS	hsa-mir-208b	"Cardiomyopathy, Hypertrophic"	25633875	Sequence variants in miRNAs of patients with HCM are not frequent and the contribution of these variants to the development of this disease was not demonstrated.
genetics_GWAS	hsa-mir-367	"Cardiomyopathy, Hypertrophic"	25633875	Sequence variants in miRNAs of patients with HCM are not frequent and the contribution of these variants to the development of this disease was not demonstrated.
genetics_GWAS	hsa-mir-499	Neoplasms [unspecific]	25640376	hsa-mir-499 rs3746444 A>G polymorphism is not associated with risk of cancer based on current evidence.
genetics_GWAS	hsa-mir-146a	"Tuberculosis, Pulmonary"	25650003	"Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations."
genetics_GWAS	hsa-mir-149	"Tuberculosis, Pulmonary"	25650003	"Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations."
genetics_GWAS	hsa-mir-196a-2	"Tuberculosis, Pulmonary"	25650003	"Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations."
genetics_GWAS	hsa-mir-499	"Tuberculosis, Pulmonary"	25650003	"Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations."
genetics_GWAS	hsa-mir-34b	Gastric Neoplasms	25658980	rs4938723 polymorphism is associated with a decreased risk of gastric cancer.
genetics_GWAS	hsa-mir-34c	Gastric Neoplasms	25658980	rs4938723 polymorphism is associated with a decreased risk of gastric cancer.
genetics_GWAS	hsa-mir-29c	Gastric Neoplasms	25661340	A miR-29c binding site genetic variant in the 3'-untranslated region of LAMTOR3 gene is associated with gastric cancer risk.
genetics_GWAS	hsa-mir-17	Osteosarcoma	25663449	"This study suggests that SNPs in RISC complex genes may be involved in osteosarcoma susceptibility, especially rs11866002 in CNOT1."
genetics_GWAS	hsa-mir-18	Osteosarcoma	25663449	"This study suggests that SNPs in RISC complex genes may be involved in osteosarcoma susceptibility, especially rs11866002 in CNOT1."
genetics_GWAS	hsa-mir-19a	Osteosarcoma	25663449	"This study suggests that SNPs in RISC complex genes may be involved in osteosarcoma susceptibility, especially rs11866002 in CNOT1."
genetics_GWAS	hsa-mir-19b-1	Osteosarcoma	25663449	"This study suggests that SNPs in RISC complex genes may be involved in osteosarcoma susceptibility, especially rs11866002 in CNOT1."
genetics_GWAS	hsa-mir-20a	Osteosarcoma	25663449	"This study suggests that SNPs in RISC complex genes may be involved in osteosarcoma susceptibility, especially rs11866002 in CNOT1."
genetics_GWAS	hsa-mir-92-1	Osteosarcoma	25663449	"This study suggests that SNPs in RISC complex genes may be involved in osteosarcoma susceptibility, especially rs11866002 in CNOT1."
genetics_GWAS	hsa-mir-124a	"Diabetes Mellitus, Type 2"	25673459	"Affection of single-nucleotide polymorphisms in miR-27a, miR-124a, and miR-146a on susceptibility to type 2 diabetes mellitus in Chinese Han people."
genetics_GWAS	hsa-mir-146a	"Diabetes Mellitus, Type 2"	25673459	"Affection of single-nucleotide polymorphisms in miR-27a, miR-124a, and miR-146a on susceptibility to type 2 diabetes mellitus in Chinese Han people."
genetics_GWAS	hsa-mir-27a	"Diabetes Mellitus, Type 2"	25673459	"Affection of single-nucleotide polymorphisms in miR-27a, miR-124a, and miR-146a on susceptibility to type 2 diabetes mellitus in Chinese Han people."
genetics_GWAS	hsa-mir-155	"Lymphoma, Large B-Cell, Diffuse"	25677902	"the miRs expression in B-NHLs[11q] provides a new suggestion, in addition to pathomorphological and clinical similarities between classical, i.e.,MYC translocation-positive BL, and B-NHLs[11q], to recognize the B-NHLs[11q] subgroup of DLBCL/BL category as a MYC translocation-negative variant of BL in most cases, and points to the potential utility of miR-155/BIC/miR-21/miR-26a for the differential diagnosis of a heterogeneous category of DLBCL/BL."
genetics_GWAS	hsa-mir-21	"Lymphoma, Large B-Cell, Diffuse"	25677902	"the miRs expression in B-NHLs[11q] provides a new suggestion, in addition to pathomorphological and clinical similarities between classical, i.e.,MYC translocation-positive BL, and B-NHLs[11q], to recognize the B-NHLs[11q] subgroup of DLBCL/BL category as a MYC translocation-negative variant of BL in most cases, and points to the potential utility of miR-155/BIC/miR-21/miR-26a for the differential diagnosis of a heterogeneous category of DLBCL/BL."
genetics_GWAS	hsa-mir-26a	"Lymphoma, Large B-Cell, Diffuse"	25677902	"the miRs expression in B-NHLs[11q] provides a new suggestion, in addition to pathomorphological and clinical similarities between classical, i.e.,MYC translocation-positive BL, and B-NHLs[11q], to recognize the B-NHLs[11q] subgroup of DLBCL/BL category as a MYC translocation-negative variant of BL in most cases, and points to the potential utility of miR-155/BIC/miR-21/miR-26a for the differential diagnosis of a heterogeneous category of DLBCL/BL."
genetics_GWAS	hsa-mir-17	Breast Neoplasms	25680407	Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer.
genetics_GWAS	hsa-mir-18	Breast Neoplasms	25680407	Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer.
genetics_GWAS	hsa-mir-19a	Breast Neoplasms	25680407	Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer.
genetics_GWAS	hsa-mir-19b-1	Breast Neoplasms	25680407	Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer.
genetics_GWAS	hsa-mir-20a	Breast Neoplasms	25680407	Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer.
genetics_GWAS	hsa-mir-92-1	Breast Neoplasms	25680407	Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer.
genetics_GWAS	hsa-mir-605	Li-Fraumeni Syndrome	25683625	A functional variant in miR-605 modifies the age of onset in Li-Fraumeni syndrome.
genetics_GWAS	hsa-mir-3162	Prostate Neoplasms	25691096	"Findings from this large association study suggest that a focus on miRSNPs, including functional evaluation, can identify candidate risk loci below currently accepted statistical levels of genome-wide significance. Studies of miRNAs and their interactions with SNPs could provide further insights into the mechanisms of prostate cancer risk."
genetics_GWAS	hsa-mir-370	Prostate Neoplasms	25691096	"Findings from this large association study suggest that a focus on miRSNPs, including functional evaluation, can identify candidate risk loci below currently accepted statistical levels of genome-wide significance. Studies of miRNAs and their interactions with SNPs could provide further insights into the mechanisms of prostate cancer risk."
genetics_GWAS	hsa-mir-146a	Gastrointestinal Neoplasms	25693929	"No significant association between miR-146a rs2910164G/C polymorphism and gastrointestinal cancer susceptibility was found in this meta-analysis. But for homozygous model, people with GG genotype may have increased risk of developing colorectal cancer."
genetics_GWAS	hsa-mir-17	"Carcinoma, Lung, Non-Small-Cell"	25716425	The rs3660G>C affects KRT81 expression and thus influences survival in early-stage NSCLC. The analysis of the rs3660G>C polymorphism may be useful to identify patients at high risk of a poor disease outcome.
genetics_GWAS	hsa-mir-20b	"Carcinoma, Lung, Non-Small-Cell"	25716425	The rs3660G>C affects KRT81 expression and thus influences survival in early-stage NSCLC. The analysis of the rs3660G>C polymorphism may be useful to identify patients at high risk of a poor disease outcome.
genetics_GWAS	hsa-mir-146a	Chronic Obstructive Pulmonary Disease	25767384	"the rs2910164 CC and GC genotype was found to be associated with an improved lung function and milder disease stages, at least partially, mediated by its ability to increase in COX2 expression and PGE2 production."
genetics_GWAS	hsa-mir-146b	Psychiatric Disorders	25771167	Our findings highlight trans effects of common variants on microRNA-mediated gene expression as an integral part of the genetic architecture of complex disorders and traits.
genetics_GWAS	hsa-mir-107	"Adenocarcinoma, Gastric"	25771723	miR-107 is dysregulated in GAC pathogenesis and the SNP rs2296616 may play a role in the process.
genetics_GWAS	hsa-mir-1206	"Leukemia, Lymphocytic, Chronic, B-Cell"	25793711	These findings suggest that polymorphisms in genes involved in miRNAs biogenesis pathway as well as in pre-miRNAs contribute to the risk of CLL. Large-scale studies are needed to validate the current findings.
genetics_GWAS	hsa-mir-196a-2	"Leukemia, Lymphocytic, Chronic, B-Cell"	25793711	These findings suggest that polymorphisms in genes involved in miRNAs biogenesis pathway as well as in pre-miRNAs contribute to the risk of CLL. Large-scale studies are needed to validate the current findings.
genetics_GWAS	hsa-mir-146a	Gastric Neoplasms	25795117	miR-27a rs895819 and miR-149 rs2292832 are of potential forewarning ability for gastric cancer risk.
genetics_GWAS	hsa-mir-149	Gastric Neoplasms	25795117	miR-27a rs895819 and miR-149 rs2292832 are of potential forewarning ability for gastric cancer risk.
genetics_GWAS	hsa-mir-196a-2	Gastric Neoplasms	25795117	miR-27a rs895819 and miR-149 rs2292832 are of potential forewarning ability for gastric cancer risk.
genetics_GWAS	hsa-mir-27a	Gastric Neoplasms	25795117	miR-27a rs895819 and miR-149 rs2292832 are of potential forewarning ability for gastric cancer risk.
genetics_GWAS	hsa-mir-499	Gastric Neoplasms	25795117	miR-27a rs895819 and miR-149 rs2292832 are of potential forewarning ability for gastric cancer risk.
genetics_GWAS	hsa-mir-548ac	Multiple Sclerosis	25795118	Susceptibility variants in the CD58 gene locus point to a role of microRNA-548ac in the pathogenesis of multiple sclerosis.
genetics_GWAS	hsa-mir-5481	Glaucoma	25809640	These data support the role of hsa-miR-548l as a regulator of FOXC1 translation and provide evidence for the c.*734A>T variant as a modifier factor for the activity of coding glaucoma-associated FOXC1 mutations.
genetics_GWAS	hsa-mir-320e	Cardiometabolic Disorders	25814643	We provide evidence for a model in which polymorphisms in miRNA-binding sites can both positively and negatively affect miRNA-mediated regulation of cardiometabolic genes.
genetics_GWAS	hsa-mir-146a	Autoimmune Diseases [unspecific]	25830862	MiR-146a rs2910164 G>C polymorphism was associated with the susceptibility of ADs.
genetics_GWAS	hsa-mir-520a	Colorectal Carcinoma	25834816	A functional variant at miR-520a binding site in PIK3CA alters susceptibility to colorectal cancer in a Chinese Han population.
genetics_GWAS	hsa-mir-146a	Ankylosing Spondylitis	25836258	Association between ankylosing spondylitis and the miR-146a and miR-499 polymorphisms.
genetics_GWAS	hsa-mir-499	Ankylosing Spondylitis	25836258	Association between ankylosing spondylitis and the miR-146a and miR-499 polymorphisms.
genetics_GWAS	hsa-mir-124-1	Neuropsychiatric Disorders [unspecific]	25841663	We showed for the first time the association of a functional polymorphism in MIR124-1 and aggressiveness. Known targets of miR-124 (such as BDNF and DRD4 genes) could explain the effect of this miRNA on behavior. A future analysis of additional novel functional polymorphisms in other brain expressed miRNAs could be useful for a deeper understanding of aggression in humans.
genetics_GWAS	hsa-mir-608	"Carcinoma, Nasopharyngeal"	25861865	Polymorphism in mature microRNA-608 sequence is associated with an increased risk of nasopharyngeal carcinoma.
genetics_GWAS	hsa-mir-146a	Cardiovascular Diseases [unspecific]	25865299	Association of miR-146a rs2910164 polymorphism with cardio-cerebrovascular diseases: A systematic review and meta-analysis.
genetics_GWAS	hsa-mir-499	"Carcinoma, Hepatocellular"	25867338	"subjects carrying the miR-499 A allele showed a greatly increased risk of HCC in subjects infected with HBV compared with subjects carrying the miR-499 A allele, with an adjusted odds ratio (95% confidence interval) of 1.53 (1.34-2.41). In conclusion, the miR-146aG>C and miR-499A>G polymorphisms do not have a role in the genetic susceptibility to HCC."
genetics_GWAS	hsa-mir-146a	Epilepsy	25891929	Our data indicate that the rs57095329 polymorphism in the promoter region of miR-146a is involved in the genetic susceptibility to DRE and the seizures frequency.
genetics_GWAS	hsa-mir-196a-2	Vitiligo	25896941	miR-196a-2 rs11614913 polymorphism is associated with vitiligo by affecting heterodimeric molecular complexes of Tyr and Tyrp1.
genetics_GWAS	hsa-mir-137	Schizophrenia	25921703	"The impact of genome wide supported microRNA-137 (MIR137) risk variants on frontal and striatal white matter integrity, neurocognitive functioning, and negative symptoms in schizophrenia."
genetics_GWAS	hsa-mir-122	"Squamous Cell Carcinoma, Cerevial"	25955681	These findings indicate that the IL1A rs3783553 polymorphism may be associated with the etiology of CSCC.
genetics_GWAS	hsa-mir-146a	Metabolic Syndrome	25958310	The C allele of miRNA-146a rs2910164 showed positive association with increased susceptibility to metabolic syndrome and its phenotypes in the study population.
genetics_GWAS	hsa-let-7c	Hepatitis B Virus Infection	25966251	"The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility."
genetics_GWAS	hsa-mir-106b	Hepatitis B Virus Infection	25966251	"The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility."
genetics_GWAS	hsa-mir-122	Hepatitis B Virus Infection	25966251	"The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility."
genetics_GWAS	hsa-mir-146a	Hepatitis B Virus Infection	25966251	"The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility."
genetics_GWAS	hsa-mir-149	Hepatitis B Virus Infection	25966251	"The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility."
genetics_GWAS	hsa-mir-196a-2	Hepatitis B Virus Infection	25966251	"The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility."
genetics_GWAS	hsa-mir-218	Hepatitis B Virus Infection	25966251	"The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility."
genetics_GWAS	hsa-mir-34b	Hepatitis B Virus Infection	25966251	"The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility."
genetics_GWAS	hsa-mir-34c	Hepatitis B Virus Infection	25966251	"The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility."
genetics_GWAS	hsa-mir-499	Hepatitis B Virus Infection	25966251	"The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility."
genetics_GWAS	hsa-mir-27a	Colorectal Carcinoma	25976406	miR-27a rs895819 polymorphism was associated with increased risk of colorectal cancer in Chinese population.
genetics_GWAS	hsa-mir-122	Oral Neoplasms	25981582	"These results suggest that IL-1¦Á 3' UTR rs3783553 polymorphism may be functional and influence susceptibility to HPV16-associated OSCC, particularly for SCCOP. Validation of our findings is warranted."
genetics_GWAS	hsa-mir-21	"Carcinoma, Cervical"	25987069	E6D25E of the HPV16As variant differed from the E6 prototype in its activities on epigenetic modulation and immune surveillance and this might be a key factor for the important role of this variant in cervical cancer progression.
genetics_GWAS	hsa-mir-214	Gastric Neoplasms	25998065	"Our data suggested that rs114673809, which is located at the miR-214 binding site in the 3'-UTR of MTHFR, may play an important role in the development of gastric cancer in a Chinese Han population."
genetics_GWAS	hsa-mir-146a	Endometrial Neoplasms	26008204	"Association of SNPs in miR-146a, miR-196a2, and miR-499 with the risk of endometrial/ovarian cancer."
genetics_GWAS	hsa-mir-196a-2	Endometrial Neoplasms	26008204	"Association of SNPs in miR-146a, miR-196a2, and miR-499 with the risk of endometrial/ovarian cancer."
genetics_GWAS	hsa-mir-499	Endometrial Neoplasms	26008204	"Association of SNPs in miR-146a, miR-196a2, and miR-499 with the risk of endometrial/ovarian cancer."
genetics_GWAS	hsa-mir-509	Colorectal Carcinoma	26010608	These findings suggest that the rs13347C/T in microRNA binding site may be potential biomarkers for genetic susceptibility to CRC.
genetics_GWAS	hsa-mir-149	Rheumatoid Arthritis	26032077	"SNP rs22928323 in miR-149 is correlated with RA in the east of Chinese Han population, whereas there is no correlation between miR-149 polymorphism and clinical characteristics in patients with RA."
genetics_GWAS	hsa-mir-146a	Behcet Disease	26053525	Association of Pre-miRNA-499 rs3746444 and Pre-miRNA-146a rs2910164 Polymorphisms and Susceptibility to Behcet's Disease.
genetics_GWAS	hsa-mir-499	Behcet Disease	26053525	Association of Pre-miRNA-499 rs3746444 and Pre-miRNA-146a rs2910164 Polymorphisms and Susceptibility to Behcet's Disease.
genetics_GWAS	hsa-mir-4293	"Squamous Cell Carcinoma, Esophageal"	26055141	miR-449b rs10061133 and miR-4293 rs12220909 polymorphisms are associated with decreased esophageal squamous cell carcinoma in a Chinese population.
genetics_GWAS	hsa-mir-449b	"Squamous Cell Carcinoma, Esophageal"	26055141	miR-449b rs10061133 and miR-4293 rs12220909 polymorphisms are associated with decreased esophageal squamous cell carcinoma in a Chinese population.
genetics_GWAS	hsa-mir-155	Melanoma	26068396	Polymorphisms in 3'UTR of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR-155 and its subsequent translation into protein. These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR-155 activity and disclose a prognostic value for TYRP1 protein in a subgroup of melanoma patients. These data support the interest in the prognostic value of melanogenic markers and propose TYRP1 to refine prognosis in patients with advanced disease.
genetics_GWAS	hsa-mir-146a	Lung Neoplasms	26083623	The interactions between miRNA SNPs and cooking oil fume exposure suggested by ORs of different combination were not statistically significant.
genetics_GWAS	hsa-mir-196a-2	Lung Neoplasms	26083623	The interactions between miRNA SNPs and cooking oil fume exposure suggested by ORs of different combination were not statistically significant.
genetics_GWAS	hsa-mir-27a	Lung Neoplasms	26083623	The interactions between miRNA SNPs and cooking oil fume exposure suggested by ORs of different combination were not statistically significant.
genetics_GWAS	hsa-mir-423	Lung Neoplasms	26083623	The interactions between miRNA SNPs and cooking oil fume exposure suggested by ORs of different combination were not statistically significant.
genetics_GWAS	hsa-mir-608	Lung Neoplasms	26083623	The interactions between miRNA SNPs and cooking oil fume exposure suggested by ORs of different combination were not statistically significant.
genetics_GWAS	hsa-mir-146a	Alzheimer Disease	26095531	A single nucleotide polymorphism in primary-microRNA-146a reduces the expression of mature microRNA-146a in patients with Alzheimer's disease and is associated with the pathogenesis of Alzheimer's disease.
genetics_GWAS	hsa-mir-196a-2	Prostate Neoplasms	26112096	"Assessment of association between genetic variants in microRNA genes hsa-miR-499,hsa-miR-196a2 and hsa-miR-27a and prostate cancer risk in Serbian population."
genetics_GWAS	hsa-mir-27a	Prostate Neoplasms	26112096	"Assessment of association between genetic variants in microRNA genes hsa-miR-499,hsa-miR-196a2 and hsa-miR-27a and prostate cancer risk in Serbian population."
genetics_GWAS	hsa-mir-499	Prostate Neoplasms	26112096	"Assessment of association between genetic variants in microRNA genes hsa-miR-499,hsa-miR-196a2 and hsa-miR-27a and prostate cancer risk in Serbian population."
genetics_GWAS	hsa-mir-146a	Melanoma	26122011	Association of microRNA 146a polymorphism rs2910164 and the risk of melanoma in an Italian population.
genetics_GWAS	hsa-mir-196a-2	Breast Neoplasms	26125831	Our results suggested that miR-146a rs2910164 G>C and miR-196a2 rs11614913 T>C may be biomarkers for predicting breast cancer risk in the Chinese population.
genetics_GWAS	hsa-mir-3622a	Colorectal Carcinoma	26147304	"Our results indicate variations in RAN rs14035, DICER1 rs3742330, XPO5 rs11077, and DROSHA rs10719 of Korean patients are significantly associated with their risk of CRC."
genetics_GWAS	hsa-mir-5582	Colorectal Carcinoma	26147304	"Our results indicate variations in RAN rs14035, DICER1 rs3742330, XPO5 rs11077, and DROSHA rs10719 of Korean patients are significantly associated with their risk of CRC."
genetics_GWAS	hsa-mir-125b	Breast Neoplasms	26190157	Evaluation the susceptibility of five polymorphisms in microRNA-binding sites to female breast cancer risk in Chinese population.
genetics_GWAS	hsa-mir-320	Breast Neoplasms	26190157	Evaluation the susceptibility of five polymorphisms in microRNA-binding sites to female breast cancer risk in Chinese population.
genetics_GWAS	hsa-mir-367	Breast Neoplasms	26190157	Evaluation the susceptibility of five polymorphisms in microRNA-binding sites to female breast cancer risk in Chinese population.
genetics_GWAS	hsa-mir-570	Viral Infectious Disease	26199425	it was demonstrated that human CYP2E1 was regulated by miR-570 in a genotype-dependent manner. This report describes the first proof that SNP in 3'-UTR of human P450 affects binding of miRNA to modulate the expression in the liver.
genetics_GWAS	hsa-mir-146a	Pulmonary Hypertension	26202355	"the results of this study demonstrate that the rs2910164 CC and GC genotype is associated with a decreased risk of pulmonary hypertension, which could be attributed to defective miRNA processing and compromised ability to inhibit production of COX-2 and PGI2."
genetics_GWAS	hsa-mir-146a	Intracranial Aneurysm	26214448	Association between the hsa-miR-146a rs2910164 functional polymorphism with susceptibility to intracranial aneurysm.
genetics_GWAS	hsa-mir-146a	"Squamous Cell Carcinoma, Oral"	26214637	"The miR-146a rs2910164 polymorphism is associated with increased risk for cervical and skin SCC. In contrast, rs2910164 in miR-146a is related to decreased risk for nasopharyngeal and oral SCC."
genetics_GWAS	hsa-mir-483	Colorectal Carcinoma	26235181	Both the single nucleotide polymorphism variants showed a positive association toward risk of lung cancer.
genetics_GWAS	hsa-mir-551a	Colorectal Carcinoma	26235181	Both the single nucleotide polymorphism variants showed a positive association toward risk of lung cancer.
genetics_GWAS	hsa-mir-219	Schizophrenia	26257337	"These findings suggest that GRIN2B may be associated with schizophrenia and interaction effects of the polymorphisms in hsa-miR-219, CAKM2G, GRIN2B and GRIN3A may confer susceptibility to schizophrenia in the Chinese Han population."
genetics_GWAS	hsa-mir-100	"Squamous Cell Carcinoma, Esophageal"	26261633	Genetic variation in miR-100 rs1834306 is associated with decreased risk for esophageal squamous cell carcinoma in Kazakh patients in northwest China.
genetics_GWAS	hsa-let-7c	Essential Hypertension	26274321	"In conclusion, our experimental results provide evidence that the T allele of rs17168525 in the 3'-UTR of myotrophin might influence the level of myotrophin protein by interfering with let-7/miR-98 binding."
genetics_GWAS	hsa-mir-503	Essential Hypertension	26274321	"In conclusion, our experimental results provide evidence that the T allele of rs17168525 in the 3'-UTR of myotrophin might influence the level of myotrophin protein by interfering with let-7/miR-98 binding."
genetics_GWAS	hsa-mir-98	Essential Hypertension	26274321	"In conclusion, our experimental results provide evidence that the T allele of rs17168525 in the 3'-UTR of myotrophin might influence the level of myotrophin protein by interfering with let-7/miR-98 binding."
genetics_GWAS	hsa-mir-146a	Head And Neck Neoplasms	26277865	Significant association between functional microRNA polymorphisms and head and neck cancer susceptibility: a comprehensive meta-analysis.
genetics_GWAS	hsa-mir-149	Head And Neck Neoplasms	26277865	Significant association between functional microRNA polymorphisms and head and neck cancer susceptibility: a comprehensive meta-analysis.
genetics_GWAS	hsa-mir-196a-2	Head And Neck Neoplasms	26277865	Significant association between functional microRNA polymorphisms and head and neck cancer susceptibility: a comprehensive meta-analysis.
genetics_GWAS	hsa-mir-499	Head And Neck Neoplasms	26277865	Significant association between functional microRNA polymorphisms and head and neck cancer susceptibility: a comprehensive meta-analysis.
genetics_GWAS	hsa-mir-27a	Colorectal Carcinoma	26302683	Genotype GG of rs895819 Functional Polymorphism Within miR-27a Might Increase Genetic Susceptibility to Colorectal Cancer in Han Chinese Population
genetics_GWAS	hsa-mir-34b	Digestive System Neoplasms	26320502	The current evidence supports the conclusion that the miR-34b/c rs4938723 polymorphism decreases an individual's susceptibility to digestive cancers.
genetics_GWAS	hsa-mir-146a	"Carcinoma, Renal Cell"	26323945	the observed association between the GG and GC genotype and poorer survival rate of RCC was at least partially mediated by the decreased expression of miR-146a.
genetics_GWAS	hsa-mir-214	Diabetes Mellitus	26329304	"We have detected the interactions of hsa-miR-214-5p/hsa-miR-550a-5p and the 3'UTR SNP of the HNF1B gene by in vitro luciferase reporter assays, and propose that the binding of such miRNAs regulates the expression of the HNF1B gene and the susceptibility of T2DM."
genetics_GWAS	hsa-mir-550a	Diabetes Mellitus	26329304	"We have detected the interactions of hsa-miR-214-5p/hsa-miR-550a-5p and the 3'UTR SNP of the HNF1B gene by in vitro luciferase reporter assays, and propose that the binding of such miRNAs regulates the expression of the HNF1B gene and the susceptibility of T2DM."
genetics_GWAS	hsa-mir-146a	Neoplasms [unspecific]	26337564	We conclude that rs2910164 may represent a valuable biomarker associated with the risk of developing specific types of cancer.
genetics_GWAS	hsa-mir-146a	Gastric Neoplasms	26345764	"Overall, this meta-analysis failed to detect an association between five common miR-146a gene polymorphisms and GC susceptibility. However, this does not necessarily completely rule out a correlation between miRNA polymorphisms and GC susceptibility."
genetics_GWAS	hsa-mir-149	Gastric Neoplasms	26345764	"Overall, this meta-analysis failed to detect an association between five common miR-146a gene polymorphisms and GC susceptibility. However, this does not necessarily completely rule out a correlation between miRNA polymorphisms and GC susceptibility."
genetics_GWAS	hsa-mir-196a-2	Gastric Neoplasms	26345764	"Overall, this meta-analysis failed to detect an association between five common miR-146a gene polymorphisms and GC susceptibility. However, this does not necessarily completely rule out a correlation between miRNA polymorphisms and GC susceptibility."
genetics_GWAS	hsa-mir-27a	Gastric Neoplasms	26345764	"Overall, this meta-analysis failed to detect an association between five common miR-146a gene polymorphisms and GC susceptibility. However, this does not necessarily completely rule out a correlation between miRNA polymorphisms and GC susceptibility."
genetics_GWAS	hsa-mir-499	Gastric Neoplasms	26345764	"Overall, this meta-analysis failed to detect an association between five common miR-146a gene polymorphisms and GC susceptibility. However, this does not necessarily completely rule out a correlation between miRNA polymorphisms and GC susceptibility."
genetics_GWAS	hsa-mir-146a	Gastric Neoplasms	26345790	"In summary, the results suggested that the miR-146a rs2910164 polymorphism was related to gastric cancer risk in Asians but not in Caucasians, and no distinct correlation seemed to exist between the miR-196a-2 rs11614913 polymorphism and the risk of gastric cancer."
genetics_GWAS	hsa-mir-196a-2	Gastric Neoplasms	26345790	"In summary, the results suggested that the miR-146a rs2910164 polymorphism was related to gastric cancer risk in Asians but not in Caucasians, and no distinct correlation seemed to exist between the miR-196a-2 rs11614913 polymorphism and the risk of gastric cancer."
genetics_GWAS	hsa-mir-196a-2	"Carcinoma, Hepatocellular"	26365437	"In conclusion,the donor miR-196a-2 rs11614913 polymorphism is associated with HCC recurrence after LT and improves the predictive value of clinical models. The overexpression of miR-196a in the liver might provide a tumor-favorable environment for the development of HCC."
genetics_GWAS	hsa-mir-219-1	"Squamous Cell Carcinoma, Esophageal"	26379361	These findings indicated that functional polymorphisms miR-219-1 rs107822G > A might change individual susceptibility to Kazakh ESCC.
genetics_GWAS	hsa-mir-505	Gastric Neoplasms	26394032	"The PSMD10 rs111638916 SNP is highly associated with an increased risk of GC in Chinese patients, and could serve as a novel biomarker for this disease."
genetics_GWAS	hsa-mir-34b	"Carcinoma, Thyroid, Papillary"	26402809	These findings indicate that the miR-34b/c rs4938723 and TP-53 Arg72Pro polymorphisms may contribute to the susceptibility of PTC.
genetics_GWAS	hsa-mir-34c	"Carcinoma, Thyroid, Papillary"	26402809	These findings indicate that the miR-34b/c rs4938723 and TP-53 Arg72Pro polymorphisms may contribute to the susceptibility of PTC.
genetics_GWAS	hsa-mir-196a-2	Gastric Neoplasms	26406571	"Our studies suggested that the miR-146a rs2910164 polymorphism might marginally contribute to a decreased risk of gastric cancer, especially in Caucasians, whereas the miR-196a2 rs11614913 polymorphism might not be associated with susceptibility to GC."
genetics_GWAS	hsa-mir-155	Epilepsy	26425555	"This study first demonstrates the association of MIR155HG/miR-155 tag SNPs with epilepsy and shows that rare CNVs were found exclusively in epileptic patients, clarifying the genetic role of miR-155 in epilepsy."
genetics_GWAS	hsa-mir-146a	Kidney Diseases [unspecific]	26426696	"There was no association of rs2910164 with susceptibility to IgAN in adults from a Chinese Han population. However, rs2910164 was correlated with the age of onset of IgAN in adult patients."
genetics_GWAS	hsa-mir-137	Schizophrenia	26429811	A GWAS SNP for Schizophrenia Is Linked to the Internal MIR137 Promoter and Supports Differential Allele-Specific Expression.
genetics_GWAS	hsa-mir-101-1	"Carcinoma, Hepatocellular"	26434859	"Our results revealed no significant association between miR-149 (rs2292832) and miR-101-1 (rs7536540) and the risk of HCC in our Thai population.However, this research is the first study of miR-149 (rs2292832) and miR-101-1 (rs7536541) in HCC in Thai populations and the results need to be confirmed with a larger population."
genetics_GWAS	hsa-mir-149	"Carcinoma, Hepatocellular"	26434859	"Our results revealed no significant association between miR-149 (rs2292832) and miR-101-1 (rs7536540) and the risk of HCC in our Thai population.However, this research is the first study of miR-149 (rs2292832) and miR-101-1 (rs7536540) in HCC in Thai populations and the results need to be confirmed with a larger population."
genetics_GWAS	hsa-mir-146a	"Carcinoma, Cervical"	26464690	"The miR-146a (rs2910164) polymorphism is significantly correlated to ethnic factor and tumor diameters. miR-146a has differential expression in cervical tissues. Allele G of miR-146a (rs2910164) is related to the high expression of miR-146a, and the progression of cervical cancer."
genetics_GWAS	hsa-mir-196a-2	"Carcinoma, Hepatocellular"	26464719	"In conclusion, miR-196a2 rs11614913 polymorphism may contribute to identifying individuals, especially in HBV-infected subjects, who are at high risk for HCC."
genetics_GWAS	hsa-mir-92a	Breast Neoplasms	26471763	"MDM4 SNP34091 status to be associated with reduced risk of breast cancer, in particular in individuals carrying the MDM2 SNP309GG genotype, but not to be associated with either lung-, colon- or prostate cancer."
genetics_GWAS	hsa-mir-146a	Breast Neoplasms	26476291	The microRNA miR146a has a potential role in the development of breast cancer and the effects of its SNPs require further inquiry to determine the nature of their influence on breast tissue and cancer.
genetics_GWAS	hsa-mir-34b	Male Infertility	26505368	Our results indicated that the MTHFR 3'-UTR rs55763075 polymorphism might modify the susceptibility to male infertility with idiopathic azoospermia.
genetics_GWAS	hsa-mir-146a	Carotid Atherosclerosis	26505665	"The miR-146a rs2910164 polymorphism might be associated with carotid vulnerable plaque risk in Chinese type 2 diabetes mellitus patients, particularly in older patients, females, those with diabetes duration of more than 10 years and those with hypertension. The transcriptional coactivator p300 rs20551 polymorphism may not be a risk factor for the development or progression of atherosclerosis in type 2 diabetes mellitus."
genetics_GWAS	hsa-mir-423	"Squamous Cell Carcinoma, Esophageal"	26518769	"Four SNPs including miR-196a2 rs11614913, miR-146a rs2910164, miR-499 rs3746444, and miR-423 rs6505162 were selected with comprehensive collection strategy and genotyped using the SNaPshot Multiplex System."
genetics_GWAS	hsa-let-7	Hematologic Neoplasms	26520014	our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.
genetics_GWAS	hsa-mir-146	Hematologic Neoplasms	26520014	our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.
genetics_GWAS	hsa-mir-150	Hematologic Neoplasms	26520014	our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.
genetics_GWAS	hsa-mir-155	Hematologic Neoplasms	26520014	our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.
genetics_GWAS	hsa-mir-15a	Hematologic Neoplasms	26520014	our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.
genetics_GWAS	hsa-mir-16-1	Hematologic Neoplasms	26520014	our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.
genetics_GWAS	hsa-mir-21	Hematologic Neoplasms	26520014	our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.
genetics_GWAS	hsa-mir-221	Hematologic Neoplasms	26520014	our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.
genetics_GWAS	hsa-mir-222	Hematologic Neoplasms	26520014	our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.
genetics_GWAS	hsa-mir-29	Hematologic Neoplasms	26520014	our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.
genetics_GWAS	hsa-mir-34	Hematologic Neoplasms	26520014	our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.
genetics_GWAS	hsa-mir-372	Hematologic Neoplasms	26520014	our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.
genetics_GWAS	hsa-mir-373	Hematologic Neoplasms	26520014	our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.
genetics_GWAS	hsa-mir-708	Hematologic Neoplasms	26520014	our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.
genetics_GWAS	hsa-mir-196a-2	Liver Cirrhosis	26529280	"In summary, rs12304647 is associated with a reduced risk of progression to HCC in patients with chronic HBV infection."
genetics_GWAS	hsa-mir-146a	Acute Coronary Syndrome	26537765	These findings indicate that miR-146a rs2910164 may act as a novel molecular marker for ACS susceptibility.
genetics_GWAS	hsa-mir-196a-2	Atrial Fibrillation	26554236	"Our data support that the pre-miR-196a2 polymorphism is associated with AF, and the C allele is a risk factor for AF."
genetics_GWAS	hsa-mir-125	Diabetic Nephropathy	26563755	"We identified miR-125a as a direct regulator of IL-6R, and the genotype of rs12976445 might be a novel predictor of the development of DN in DM."
genetics_GWAS	hsa-mir-145	Breast Neoplasms	26577090	Our study is the first to report an association between a miR-SNP in MIR145 and breast cancer risk in individuals of Caucasian background. This finding requires further validation through genotyping of larger cohorts or in individuals of different ethnicities to determine the potential significance of this finding as well as studies aimed to determine functional significance.
genetics_GWAS	hsa-mir-499	Gastric Neoplasms	26597478	The present study indicated that miR-499 rs3746444 might contribute to GC risk and this SNP could be developed as a biomarker for GC prediction.
genetics_GWAS	hsa-mir-146a	"Stroke, Ischemic"	26608782	"Although the 3 SNPs might be associated with IS, the association varied significantly in different countries."
genetics_GWAS	hsa-mir-196a-2	"Stroke, Ischemic"	26608782	"Although the 3 SNPs might be associated with IS, the association varied significantly in different countries."
genetics_GWAS	hsa-mir-499	"Stroke, Ischemic"	26608782	"Although the 3 SNPs might be associated with IS, the association varied significantly in different countries."
genetics_GWAS	hsa-mir-149	"Squamous Cell Carcinoma, Oral"	26625766	Our study suggests that miR-196a2C>T and miR-149C>T polymorphisms may play crucial roles in the development of OSCC in South Indian subjects.
genetics_GWAS	hsa-mir-124	Neoplasms [unspecific]	26625819	This meta-analysis suggests that the miR-124 rs531564 C > G polymorphism is an important risk factor for cancers among the Chinese population.
genetics_GWAS	hsa-let-7a	"Carcinoma, Colon"	26630397	"Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer."
genetics_GWAS	hsa-mir-143	"Carcinoma, Colon"	26630397	"Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer."
genetics_GWAS	hsa-mir-145	"Carcinoma, Colon"	26630397	"Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer."
genetics_GWAS	hsa-mir-146a	"Carcinoma, Colon"	26630397	"Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer."
genetics_GWAS	hsa-mir-19a	"Carcinoma, Colon"	26630397	"Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer."
genetics_GWAS	hsa-mir-19b	"Carcinoma, Colon"	26630397	"Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer."
genetics_GWAS	hsa-mir-214	"Carcinoma, Colon"	26630397	"Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer."
genetics_GWAS	hsa-mir-25	"Carcinoma, Colon"	26630397	"Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer."
genetics_GWAS	hsa-mir-525	"Carcinoma, Colon"	26630397	"Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer."
genetics_GWAS	hsa-mir-140	Bladder Neoplasms	26695686	"Together, these results suggest that rs35592567 in TP63 may be a novel causal variant contributing to the susceptibility to bladder cancer, which provides additional insight into the pathogenesis of bladder carcinogenesis."
genetics_GWAS	hsa-mir-196a-2	Breast Neoplasms	26710106	Somatic Mutation of the SNP rs11614913 and Its Association with Increased MIR 196A2 Expression in Breast Cancer.
genetics_GWAS	hsa-mir-603	Breast Neoplasms	26718432	"In conclusion,the findings indicated that Mir603 rs11014002 T allele might contribute to decrease the risk of BC in a sample of Iranian population. Further studies with larger sample sizes and different ethnicities are warranted to confirm our findings."
genetics_GWAS	hsa-mir-449a	Gastric Neoplasms	26722545	"In conclusion, our findings suggest that miR-449a rs112310158 is a genetic risk factor for GC."
genetics_GWAS	hsa-mir-146a	"Carcinoma, Thyroid, Papillary"	26722556	"Our study indicated that the miR-146a polymorphism was significantly associated with PTC risk. In contrast, meta-analysis revealed no evidence of association between miR-146a variants and PTC risk. Further studies are required to elucidate the role of miR-146a in the etiology of PTC."
genetics_GWAS	hsa-mir-492	"Carcinoma, Hepatocellular"	26753964	miR-492G>C polymorphism (rs2289030) is associated with overall survival of hepatocellular carcinoma patients.
genetics_GWAS	hsa-mir-146a	Breast Neoplasms	26785832	"e identified one rare variant in MIR146A, four in MIR146B, five in BRCA1 3'-UTR and one in BRCA2 3'-UTR in 716 index cases and 619 controls."
genetics_GWAS	hsa-mir-146a	Ovarian Neoplasms	26785832	"e identified one rare variant in MIR146A, four in MIR146B, five in BRCA1 3'-UTR and one in BRCA2 3'-UTR in 716 index cases and 619 controls."
genetics_GWAS	hsa-mir-146b	Breast Neoplasms	26785832	"we identified one rare variant in MIR146A, four in MIR146B, five in BRCA1 3'-UTR and one in BRCA2 3'-UTR in 716 index cases and 619 controls."
genetics_GWAS	hsa-mir-146b	Ovarian Neoplasms	26785832	"we identified one rare variant in MIR146A, four in MIR146B, five in BRCA1 3'-UTR and one in BRCA2 3'-UTR in 716 index cases and 619 controls."
genetics_GWAS	hsa-mir-146a	Colorectal Carcinoma	26813595	"SNPs in the miRNA genes are important for tumorigenesis. The changes by hsa-mir-146a rs1052918 C>G may result in loss of Wnt, constant activation of the Wnt signaling pathway, and uncontrolled cell proliferation and tumor progression."
genetics_GWAS	hsa-mir-608	"Carcinoma, Hepatocellular"	26815502	MiR-608 rs4919510 is associated with prognosis of hepatocellular carcinoma.
genetics_GWAS	hsa-mir-149	"Carcinoma, Hepatocellular"	26823863	"Predictive role of miR-146a rs2910164 (C>G), miR-149 rs2292832 (T>C), miR-196a2 rs11614913 (T>C) and miR-499 rs3746444 (T>C) in the development of hepatocellular carcinoma."
genetics_GWAS	hsa-mir-137	Schizophrenia	26836412	Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia.
genetics_GWAS	hsa-mir-199a	"Adenocarcinoma, Pancreatic Ductal"	26872370	our study demonstrates that host genetic variants could disturb the regulation of the miR-199a/HIF1A regulatory loop and alter PDAC risk and poor prognosis.
genetics_GWAS	hsa-mir-146a	Atherosclerosis	26875519	Apolipoprotein E Epsilon 4 Enhances the Association between the rs2910164 Polymorphism of miR-146a and Risk of Atherosclerotic Cerebral Infarction.
genetics_GWAS	hsa-mir-146a	Coronary Artery Disease	26909569	"Our data provide the first evidence for the association of miR-146a rs2910164 and TCF21 rs12190287 with CAD in an Iranian population, encouraging further research to elucidate the disease-related effects of miR-146a rs2910164."
genetics_GWAS	hsa-mir-146a	Lung Neoplasms	26926727	"Rs11614913, rs12894467 and rs2910164 polymorphism were potentially associated with primary lung cancer in Fujian Han population."
genetics_GWAS	hsa-mir-196a-2	Lung Neoplasms	26926727	"Rs11614913, rs12894467 and rs2910164 polymorphism were potentially associated with primary lung cancer in Fujian Han population."
genetics_GWAS	hsa-mir-26a-1	Lung Neoplasms	26926727	"Rs11614913, rs12894467 and rs2910164 polymorphism were potentially associated with primary lung cancer in Fujian Han population."
genetics_GWAS	hsa-mir-27a	Lung Neoplasms	26926727	"Rs11614913, rs12894467 and rs2910164 polymorphism were potentially associated with primary lung cancer in Fujian Han population."
genetics_GWAS	hsa-mir-300	Lung Neoplasms	26926727	"Rs11614913, rs12894467 and rs2910164 polymorphism were potentially associated with primary lung cancer in Fujian Han population."
genetics_GWAS	hsa-mir-15a	"Leukemia, Lymphocytic, Chronic, B-Cell"	26959643	mutations in the mir-15a/16-1 loci are responsible for decreased expression
genetics_GWAS	hsa-mir-423	Lung Neoplasms	26973201	These findings suggest that miR-146a rs2910164C>G and miR-423 rs6505162C>A polymorphisms may contribute to genetic susceptibility to lung cancer and lung adenocarcinoma in Chinese non-smoking females.
genetics_GWAS	hsa-mir-146a	Diabetic Nephropathy	26997512	Rs2910164 is significantly associated with microvascular complications DN in patients with T1DM and DME in patients with T2DM.
genetics_GWAS	hsa-mir-146a	Diabetic Retinopathy	26997512	Rs2910164 is significantly associated with microvascular complications DN in patients with T1DM and DME in patients with T2DM.
genetics_GWAS	hsa-mir-618	"Stroke, Ischemic"	27011381	Our findings suggest that miR-618 SNP rs2682818 may play an important role in the recurrence of ischemic stroke.
genetics_GWAS	hsa-mir-149	Squamous Cell Carcinoma	27050146	hsa-mir-149 rs2292832 and hsa-mir-499 rs3746444 polymorphisms play a significant role in the prognosis of SCCNOP
genetics_GWAS	hsa-mir-365	Neuropsychiatric Disorders [unspecific]	27074815	single nucleotide polymorphism (SNP) rs2235749 (in high linkage disequilibrium with rs910080) modifies striatal PDYN expression via impaired binding of miR-365
genetics_GWAS	hsa-mir-137	Schizophrenia	27096222	A single nucleotide polymorphism rs1625579 in the miR-137 gene has recently been reported to confer risk of schizophrenia
genetics_GWAS	hsa-mir-146a	Psoriasis	27098222	"The miR-146a SNPs rs2910164, rs57095329, rs2431697 are associated with susceptibility to certain autoimmune diseases."
genetics_GWAS	hsa-mir-149	"Carcinoma, Hepatocellular"	27141902	"A meta-analysis of microRNA-149, microRNA-499 gene polymorphism and susceptibility to hepatocellular carcinoma"
genetics_GWAS	hsa-mir-146a	Graft-Versus-Host Disease	27156151	"expression levels of miR-146aC>G, miR-196a2T>C and putative gene-gene interaction between miR-146a, miR-196a2, miR-149 may be involved in RIF development in Korean women."
genetics_GWAS	hsa-mir-149	Graft-Versus-Host Disease	27156151	"expression levels of miR-146aC>G, miR-196a2T>C and putative gene-gene interaction between miR-146a, miR-196a2, miR-149 may be involved in RIF development in Korean women."
genetics_GWAS	hsa-mir-196a-2	Graft-Versus-Host Disease	27156151	"expression levels of miR-146aC>G, miR-196a2T>C and putative gene-gene interaction between miR-146a, miR-196a2, miR-149 may be involved in RIF development in Korean women."
genetics_GWAS	hsa-mir-499a	Graft-Versus-Host Disease	27156151	"expression levels of miR-146aC>G, miR-196a2T>C and putative gene-gene interaction between miR-146a, miR-196a2, miR-149 may be involved in RIF development in Korean women."
genetics_GWAS	hsa-mir-124	Mesial Temporal Lobe Epilepsy	27188998	"In this study, the effect of the SNP of one neuronal miRNA, miR-124, on susceptibility to MTLE was investigated using a case control study."
genetics_GWAS	hsa-mir-34b	Osteoporosis	27227383	The present findings indicate that pri-miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms may contribute to the risk of OP.
genetics_GWAS	hsa-mir-34c	Osteoporosis	27227383	The present findings indicate that pri-miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms may contribute to the risk of OP.
genetics_GWAS	hsa-let-7	Colorectal Carcinoma	27234654	rs868 is associated with lower TGFBR1 expression thereby increasing CRC risk.
genetics_GWAS	hsa-mir-130a	"Stroke, Ischemic"	27246008	"Association of miR-34a, miR-130a, miR-150 and miR-155 polymorphisms with the risk of ischemic stroke"
genetics_GWAS	hsa-mir-150	"Stroke, Ischemic"	27246008	"Association of miR-34a, miR-130a, miR-150 and miR-155 polymorphisms with the risk of ischemic stroke"
genetics_GWAS	hsa-mir-155	"Stroke, Ischemic"	27246008	"Association of miR-34a, miR-130a, miR-150 and miR-155 polymorphisms with the risk of ischemic stroke"
genetics_GWAS	hsa-mir-34a	"Stroke, Ischemic"	27246008	"Association of miR-34a, miR-130a, miR-150 and miR-155 polymorphisms with the risk of ischemic stroke"
genetics_GWAS	hsa-mir-146a	Gastric Neoplasms	27267319	rs2910164 of miR-146a is associated with GC
genetics_GWAS	hsa-mir-27a	"Diabetes Mellitus, Type 2"	27300034	The pre-mir-27a variant rs895819 may contribute to type 2 diabetes mellitus susceptibility
genetics_GWAS	hsa-mir-501	"Carcinoma, Hepatocellular"	27310251	We identified a novel SNP located in miR-501 acting as an important factor of the HCC susceptibility
genetics_GWAS	hsa-mir-214	"Squamous Cell Carcinoma, Esophageal"	27323028	esophageal squamous cell carcinoma
genetics_GWAS	hsa-mir-146a	Rheumatoid Arthritis	27342690	12 single nucleotide polymorphisms
genetics_GWAS	hsa-mir-502	"Carcinoma, Renal Cell, Clear-Cell"	27346408	Polymorphism at the miR-502 binding site in the 3' untranslated region of SET8 gene is associated with the risk of clear cell renal cell carcinoma
genetics_GWAS	hsa-mir-149	"Carcinoma, Hepatocellular"	27348444	MIR-149 gene rs2292832 polymorphism contributed to the risk of HCC
genetics_GWAS	hsa-mir-370	Colorectal Carcinoma	27354594	"rs2279398G>A may affect the expression of DOK3 by altering the miRNA binding efficiency at the miRNA-binding sites of the 3'-UTR in DOK3, thereby impacting CRC tumorigenesis."
genetics_GWAS	hsa-mir-1273d	Tooth Agenesis	27362534	our findings indicate that rs15705 and rs317250 are associated with the susceptibility of non-syndromic tooth agenesis by possibly affecting miRNAs and mRNA interaction.
genetics_GWAS	hsa-mir-4639	Tooth Agenesis	27362534	rs15705 and rs317250 are associated with the susceptibility of non-syndromic tooth agenesis by possibly affecting miRNAs and mRNA interaction.
genetics_GWAS	hsa-mir-429	"Carcinoma, Lung, Non-Small-Cell"	27374108	rs9660710 in miR-200b/200a/429 cluster and rs763354 in miR-30a might modify the susceptibility to NSCLC.
genetics_GWAS	hsa-mir-146a	Hypertension	27379568	"This study suggests that the variant of miR-146aC>G polymorphism and allelic combinations, at least in Koreans, affect susceptibility to hypertension."
genetics_GWAS	hsa-mir-6826	Breast Neoplasms	27380242	"We systematically put together a list of 822 and 10,468 genetic variants among primary miRNA sequences and 38 genes in the miRNA biogenesis pathway"
genetics_GWAS	hsa-mir-608	Rectal Neoplasms	27381831	Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients.
genetics_GWAS	hsa-mir-152	Asthma	27383317	Single nucleotide polymorphisms in the promoter region of mir-133a-1 and in pre-mir-152 rs1707 may contribute to the risk of asthma in a Chinese Han population.
genetics_GWAS	hsa-mir-142	"Lymphoma, Follicular"	27389057	"We found recurrent mutations of miR-142, which has not been previously been reported to be mutated in FL/tFL."
genetics_GWAS	hsa-mir-142	"Lymphoma, Large B-Cell, Diffuse"	27390358	"Additionally, we detected recurrent mutations of hsa-miR-142 in diffuse large B-cell lymphomas and follicular lymphomas, and editing of the hsa-miR-376 cluster, providing evidence for microRNA editing in lymphomagenesis."
genetics_GWAS	hsa-mir-376	"Lymphoma, Large B-Cell, Diffuse"	27390358	"we detected recurrent mutations of hsa-miR-142 in diffuse large B-cell lymphomas and follicular lymphomas, and editing of the hsa-miR-376 cluster, providing evidence for microRNA editing in lymphomagenesis."
genetics_GWAS	hsa-mir-483	"Squamous Cell Carcinoma, Esophageal"	27420938	SNP at miR-483-5p-binding site in the 3'-untranslated region of the BSG gene is associated with susceptibility to esophageal cancer in a Chinese population.
genetics_GWAS	hsa-mir-584	Pemphigus	27424220	"Collectively, these results suggest that a disease-associated SNP located within the 3'UTR of KLRG1 directly interferes with miR-584-5p binding, allowing for KLRG1 mRNA differential accumulation, which in turn may contribute to pathogenesis of autoimmune diseases, such as pemphigus."
genetics_GWAS	hsa-mir-206	Schizophrenia	27424800	Our study therefore suggests that miR-206 may contribute to schizophrenia risk through allele-dependent regulation of the genome-wide significant gene NT5C2.
genetics_GWAS	hsa-let-7a	Osteosarcoma	27430246	"Taken together, the findings of the present study demonstrated that the KRAS 3'-UTR rs61764370 polymorphism interfered with miRNA/mRNA interaction, and showed that the minor allele was associated with an elevated risk of developing metastatic disease in OS."
genetics_GWAS	hsa-mir-146a	Coronary Artery Disease	27430349	"miRNA polymorphisms (miR�46a, miR�49, miR�96a2 and miR�99) are associated with the risk of coronary artery disease."
genetics_GWAS	hsa-mir-149	Coronary Artery Disease	27430349	"miRNA polymorphisms (miR�46a, miR�49, miR�96a2 and miR�99) are associated with the risk of coronary artery disease."
genetics_GWAS	hsa-mir-196a-2	Coronary Artery Disease	27430349	"miRNA polymorphisms (miR�46a, miR�49, miR�96a2 and miR�99) are associated with the risk of coronary artery disease."
genetics_GWAS	hsa-mir-499	Coronary Artery Disease	27430349	"miRNA polymorphisms (miR�46a, miR�49, miR�96a2 and miR�99) are associated with the risk of coronary artery disease."
genetics_GWAS	hsa-mir-146a	Asthma	27431205	"The miR�46a rs2910164 polymorphism CC genotype was identified to be significantly associated with a decreased risk of BHR in response to intubation when compared with the GG or GC genotype (odds ratio, 0.38; confidence interval, 0.18�.78)."
genetics_GWAS	hsa-mir-125b	Cataract	27431420	rs78378222 polymorphism in the 3'-untranslated region of TP53 contributes to development of age-associated cataracts by modifying microRNA-125b-induced apoptosis of lens epithelial cells.
genetics_GWAS	hsa-mir-146a	Breast Neoplasms	27434289	"Logistic regression data represented the C allele of rs2910164 (OR = 4.00, p= 0.0037) as the risk allele and associated with Her2-positive phenotype."
genetics_GWAS	hsa-mir-143	Bladder Neoplasms	27438131	These findings suggest that the functional rs353293 polymorphism may be a useful biomarker to predict the risk of bladder cancer.
genetics_GWAS	hsa-mir-145	Bladder Neoplasms	27438131	These findings suggest that the functional rs353293 polymorphism may be a useful biomarker to predict the risk of bladder cancer.
genetics_GWAS	hsa-mir-145	Colorectal Carcinoma	27444415	These findings indicate that the rs353292 polymorphism is functional and may be a risk factor for the development of CRC.
genetics_GWAS	hsa-mir-499	"Carcinoma, Hepatocellular"	27453271	miR-499 rs3746444 was significantly associated with an increased the risk of HCC.
genetics_GWAS	hsa-mir-146a	Ossification of Posterior Longitudinal Ligament	27454313	The miR-146a/-149/-196a2/-499 allele combinations may be a genetic risk factor for cervical OPLL in the Korean population.
genetics_GWAS	hsa-mir-149	Ossification of Posterior Longitudinal Ligament	27454313	The miR-146a/-149/-196a2/-499 allele combinations may be a genetic risk factor for cervical OPLL in the Korean population.
genetics_GWAS	hsa-mir-196a-2	Ossification of Posterior Longitudinal Ligament	27454313	The miR-146a/-149/-196a2/-499 allele combinations may be a genetic risk factor for cervical OPLL in the Korean population.
genetics_GWAS	hsa-mir-499	Ossification of Posterior Longitudinal Ligament	27454313	The results indicate that GG genotype of miR-499 is associated with significantly higher risks of OPLL in the segmental OPLL group.
genetics_GWAS	hsa-mir-196a-2	Asthma	27487239	microRNA-196a2 rs11614913 polymorphism might be associated with asthma severity in our sample of the Egyptian population.
genetics_GWAS	hsa-mir-149	"Squamous Cell Carcinoma, Head and Neck"	27515039	"However, no significant association was detected between the other three SNPs (miR-149 rs2292832, miR-146a rs2910164, and miR-608 rs4919510) and HNSCC risk."
genetics_GWAS	hsa-mir-1269b	"Carcinoma, Oral"	27525378	"Genetic variants in microRNA-146a (C>G) and microRNA-1269b (G>C) are associated with the decreased risk of oral premalignant lesions, oral cancer, and pharyngeal cancer."
genetics_GWAS	hsa-mir-146a	"Carcinoma, Oral"	27525378	"Genetic variants in microRNA-146a (C>G) and microRNA-1269b (G>C) are associated with the decreased risk of oral premalignant lesions, oral cancer, and pharyngeal cancer."
genetics_GWAS	hsa-mir-137	Schizophrenia	27525637	"Genome-wide association studies (GWAS) have identified a region at chromosome 1p21.3, containing the microRNA MIR137, to be among the most significant associations for schizophrenia."
genetics_GWAS	hsa-let-7	"Stroke, Ischemic"	27530126	An rs13293512 polymorphism in the promoter of let-7 is associated with a reduced risk of ischemic stroke.
genetics_GWAS	hsa-mir-155	Neoplasms [unspecific]	27531892	Our findings suggested that miR-155 and its functional variant rs767649 might contribute to the increased risk and poor prognosis of HCC
genetics_GWAS	hsa-mir-182	Glaucoma	27537254	A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium.
genetics_GWAS	hsa-mir-27a	Obesity	27537871	MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population.
genetics_GWAS	hsa-mir-124a	Osteosarcoma	27540978	Single nucleotide polymorphism of hsa-miR-124a affects risk and prognosis of osteosarcoma.
genetics_GWAS	hsa-mir-526b	"Squamous Cell Carcinoma, Esophageal"	27583835	A genetic polymorphism at miR-526b binding-site in the lincRNA-NR_024015 exon confers risk of esophageal squamous cell carcinoma in a population of North China.
genetics_GWAS	hsa-mir-130b	"Stroke, Ischemic"	27603512	"Association of the Single Nucleotide Polymorphisms in microRNAs 130b, 200b, and 495 with Ischemic Stroke Susceptibility and Post-Stroke Mortality."
genetics_GWAS	hsa-mir-200b	"Stroke, Ischemic"	27603512	"Association of the Single Nucleotide Polymorphisms in microRNAs 130b, 200b, and 495 with Ischemic Stroke Susceptibility and Post-Stroke Mortality."
genetics_GWAS	hsa-mir-495	"Stroke, Ischemic"	27603512	"Association of the Single Nucleotide Polymorphisms in microRNAs 130b, 200b, and 495 with Ischemic Stroke Susceptibility and Post-Stroke Mortality."
genetics_GWAS	hsa-mir-200b	"Carcinoma, Breast"	27609814	"Mutation of putative miRNA-binding sites (miR-374a/b, miR-200b/c, miR-29a/b/c, miR-488) in these regions did not have significant impact on 3'UTR activity"
genetics_GWAS	hsa-mir-200c	"Carcinoma, Breast"	27609814	"Mutation of putative miRNA-binding sites (miR-374a/b, miR-200b/c, miR-29a/b/c, miR-488) in these regions did not have significant impact on 3'UTR activity"
genetics_GWAS	hsa-mir-29a	"Carcinoma, Breast"	27609814	"Mutation of putative miRNA-binding sites (miR-374a/b, miR-200b/c, miR-29a/b/c, miR-488) in these regions did not have significant impact on 4'UTR activity"
genetics_GWAS	hsa-mir-29b	"Carcinoma, Breast"	27609814	"Mutation of putative miRNA-binding sites (miR-374a/b, miR-200b/c, miR-29a/b/c, miR-488) in these regions did not have significant impact on 5'UTR activity"
genetics_GWAS	hsa-mir-374a	"Carcinoma, Breast"	27609814	"Mutation of putative miRNA-binding sites (miR-374a/b, miR-200b/c, miR-29a/b/c, miR-488) in these regions did not have significant impact on 6'UTR activity"
genetics_GWAS	hsa-mir-374b	"Carcinoma, Breast"	27609814	"Mutation of putative miRNA-binding sites (miR-374a/b, miR-200b/c, miR-29a/b/c, miR-488) in these regions did not have significant impact on 7'UTR activity"
genetics_GWAS	hsa-mir-488	"Carcinoma, Breast"	27609814	"Mutation of putative miRNA-binding sites (miR-374a/b, miR-200b/c, miR-29a/b/c, miR-488) in these regions did not have significant impact on 8'UTR activity"
genetics_GWAS	hsa-mir-214	"Carcinoma, Hepatocellular"	27619679	U/G SNP rs111904020 in 3'UTR of STAT3 regulated by miR-214 promotes hepatocellular carcinoma development in Chinese population.
genetics_GWAS	hsa-mir-149	Lung Neoplasms	27685326	MicroRNA-149 rs2292832 polymorphism may not be associated with lung cancer risk in Chinese non-smoking female
genetics_GWAS	hsa-mir-146a	"Carcinoma, Ovarian"	27706635	miR-146a and miR-196a2 polymorphisms in ovarian cancer risk.
genetics_GWAS	hsa-mir-196a-2	"Carcinoma, Ovarian"	27706635	miR-146a and miR-196a2 polymorphisms in ovarian cancer risk.
genetics_GWAS	hsa-mir-146a	"Carcinoma, Colon"	27706637	MicroRNA variants and colorectal cancer risk: a meta-analysis.
genetics_GWAS	hsa-mir-149	"Carcinoma, Colon"	27706637	MicroRNA variants and colorectal cancer risk: a meta-analysis.
genetics_GWAS	hsa-mir-196a	"Carcinoma, Colon"	27706637	MicroRNA variants and colorectal cancer risk: a meta-analysis.
genetics_GWAS	hsa-mir-27a	"Carcinoma, Colon"	27706637	MicroRNA variants and colorectal cancer risk: a meta-analysis.
genetics_GWAS	hsa-mir-499	"Carcinoma, Colon"	27706637	MicroRNA variants and colorectal cancer risk: a meta-analysis.
genetics_GWAS	hsa-mir-146a	"Carcinoma, Hepatocellular"	27706712	"Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma."
genetics_GWAS	hsa-mir-196a	"Carcinoma, Hepatocellular"	27706712	"Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma."
genetics_GWAS	hsa-mir-499	"Carcinoma, Hepatocellular"	27706712	"Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma."
genetics_GWAS	hsa-mir-27a	"Carcinoma, Colon"	27751356	Association between microRNA-27a rs895819 polymorphism and risk of colorectal cancer: A meta-analysis.
genetics_GWAS	hsa-mir-196a-2	Glioma	27796868	Effect of rs11614913 Polymorphism on Mature miR196a2 Expression and its Target Gene HOXC8 Expression in Human Glioma.
genetics_GWAS	hsa-mir-34a	Neuroblastoma	27805929	Genetic variant rs3750625 in the 3'UTR of ADRA2A affects stress-dependent acute pain severity after trauma and alters a microRNA-34a regulatory site.
genetics_GWAS	hsa-mir-627	"Carcinoma, Breast"	27807724	rs15869 at miRNA binding site in BRCA2 is associated with breast cancer susceptibility.
genetics_GWAS	hsa-mir-34b	"Carcinoma, Hepatocellular"	27808368	Association between polymorphisms in the promoter region of pri-miR-34b/c and risk of hepatocellular carcinoma.
genetics_GWAS	hsa-mir-34c	"Carcinoma, Hepatocellular"	27808368	Association between polymorphisms in the promoter region of pri-miR-34b/c and risk of hepatocellular carcinoma.
genetics_GWAS	hsa-mir-196a-2	Congenital Heart Diseases	27813602	"Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population."
genetics_GWAS	hsa-mir-27a	Congenital Heart Diseases	27813602	"Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population."
genetics_GWAS	hsa-mir-499	Congenital Heart Diseases	27813602	"Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population."
genetics_GWAS	hsa-mir-125a	"Carcinoma, Hepatocellular"	27814341	Association Between microRNA-125a rs12976445 C>T Polymorphism and 18F-Fluorodeoxyglucose (18FDG) Uptake: Clinical and Metabolic Response in Patients with Non-Small Cell Lung Cancer.
genetics_GWAS	hsa-mir-146a	Kaposi Sarcoma	27819716	Association of genetic variations in miR-146a rs2910164 and miR-149 rs11614913 with the development of classic Kaposi sarcoma.
genetics_GWAS	hsa-mir-149	Kaposi Sarcoma	27819716	Association of genetic variations in miR-146a rs2910164 and miR-149 rs11614913 with the development of classic Kaposi sarcoma.
genetics_GWAS	hsa-mir-146a	"Carcinoma, Colon"	27824903	miR-146a Polymorphism (rs2910164) Predicts Colorectal Cancer Patients' Susceptibility to Liver Metastasis.
genetics_GWAS	hsa-mir-205	"Carcinoma, Breast"	27885248	Rs3842530 Polymorphism in MicroRNA-205 Host Gene in Lung and Breast Cancer Patients.
genetics_GWAS	hsa-mir-146a	"Carcinoma, Hepatocellular"	27886162	miR-146a rs2910164 and hepatocellular carcinoma: a meta-analysis.
genetics_GWAS	hsa-mir-34b	"Leukemia, Lymphoblastic, Acute, Childhood"	27886674	Pri-miR-34b/c rs4938723 polymorphism is associated with the risk of childhood acute lymphoblastic leukemia.
genetics_GWAS	hsa-mir-34c	"Leukemia, Lymphoblastic, Acute, Childhood"	27886674	Pri-miR-34b/c rs4938723 polymorphism is associated with the risk of childhood acute lymphoblastic leukemia.
genetics_GWAS	hsa-mir-27a	Human Immunodeficiency Virus Infection	27919232	microRNA-27a rs895819 is associated with obesity in HIV infected preeclamptic Black South African women on HAART.
genetics_GWAS	hsa-mir-34b	"Carcinoma, Prostate"	27983526	Pri-miR-34b/c rs4938723 polymorphism increased the risk of prostate cancer.
genetics_GWAS	hsa-mir-34c	"Carcinoma, Prostate"	27983526	Pri-miR-34b/c rs4938723 polymorphism increased the risk of prostate cancer.
genetics_GWAS	hsa-let-7	Liver Cirrhosis	27992614	A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men.
genetics_GWAS	hsa-mir-3131	"Carcinoma, Hepatocellular"	28034876	An indel polymorphism within pre-miR3131 confers risk for hepatocellular carcinoma.
genetics_GWAS	hsa-mir-1269a	"Carcinoma, Hepatocellular"	28081866	A single nucleotide variant in microRNA-1269a promotes the occurrence and process of hepatocellular carcinoma by targeting to oncogenes SPATS2L and LRP6.
genetics_GWAS	hsa-mir-122	Chronic Hepatitis C	28082397	Differential hepatitis C virus RNA target site selection and host factor activities of naturally occurring miR-122 3? variants.
genetics_GWAS	hsa-mir-146a	Rheumatoid Arthritis	28083614	Significance of Polymorphism and Expression of miR-146a and NFkB1 Genetic Variants in Patients with Rheumatoid Arthritis.
genetics_GWAS	hsa-mir-146a	"Diabetes Mellitus, Type 2"	28101643	Polymorphisms in genes encoding miR-155 and miR-146a are associated with protection to type 1 diabetes mellitus.
genetics_GWAS	hsa-mir-155	"Diabetes Mellitus, Type 2"	28101643	Polymorphisms in genes encoding miR-155 and miR-146a are associated with protection to type 1 diabetes mellitus.
genetics_GWAS	hsa-mir-34b	Retinoblastoma	28106538	A polymorphism in mir-34b/c as a potential biomarker for early onset of hereditary retinoblastoma.
genetics_GWAS	hsa-mir-34c	Retinoblastoma	28106538	A polymorphism in mir-34b/c as a potential biomarker for early onset of hereditary retinoblastoma.
genetics_GWAS	hsa-mir-1203	"Stroke, Ischemic"	28171870	Methylene Tetrahydrofolate Reductase (MTHFR) rs868014 Polymorphism Regulated by miR-1203 Associates with Risk and Short Term Outcome of Ischemic Stroke.
genetics_GWAS	hsa-mir-149	Allergic Rhinitis	28181414	A functional variant of miRNA-149 confers risk for allergic rhinitis and comorbid asthma in Chinese children.
genetics_GWAS	hsa-mir-146a	"Carcinoma, Hepatocellular"	28188097	"Our findings supported the proposition that the polymorphisms of miR-146a rs2910164, miR-196a2 rs11614913, and miR-196a2 rs11614913 may contribute to the susceptibility of HCC"
genetics_GWAS	hsa-mir-196a	"Carcinoma, Hepatocellular"	28188097	"Our findings supported the proposition that the polymorphisms of miR-146a rs2910164, miR-196a2 rs11614913, and miR-196a2 rs11614913 may contribute to the susceptibility of HCC"
genetics_GWAS	hsa-mir-27b	"Carcinoma, Gastric"	28214904	rs10719 Polymorphism Located within DROSHA 3'-Untranslated Region is Responsible for Development of Primary Hypertension by Disrupting Binding with microRNA-27b.
genetics_GWAS	hsa-mir-199a	"Stroke, Ischemic"	28234972	the +936C/T variants significantly increased the risk of poorer stroke outcome by affecting the bindings of miR-199a and miR-199b to VEGF mRNA at the rs30250340 polymorphic site
genetics_GWAS	hsa-mir-199b	"Stroke, Ischemic"	28234972	the +936C/T variants significantly increased the risk of poorer stroke outcome by affecting the bindings of miR-199a and miR-199b to VEGF mRNA at the rs30250340 polymorphic site
genetics_GWAS	hsa-mir-126	Endometriosis	28277133	mir-126 rs4636297 and TGF¦ÂRI rs334348 functional gene variants are associated with susceptibility to endometriosis and its severity.
genetics_GWAS	hsa-mir-218	"Carcinoma, Gastric"	28298809	"Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis."
genetics_GWAS	hsa-mir-219	"Carcinoma, Gastric"	28298809	"Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis."
genetics_GWAS	hsa-mir-34b	"Carcinoma, Gastric"	28298809	"Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis."
genetics_GWAS	hsa-mir-34c	"Carcinoma, Gastric"	28298809	"Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis."
genetics_GWAS	hsa-mir-938	"Carcinoma, Gastric"	28298809	"Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis."
genetics_GWAS	hsa-mir-196a	"Colitis, Ulcerative"	28301487	Association of miR-196a-2 and miR-499 variants with ulcerative colitis and their correlation with expression of respective miRNAs.
genetics_GWAS	hsa-mir-499	"Colitis, Ulcerative"	28301487	Association of miR-196a-2 and miR-499 variants with ulcerative colitis and their correlation with expression of respective miRNAs.
genetics_GWAS	hsa-let-7	Macular Degeneration	28343170	"miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD)."
genetics_GWAS	hsa-let-7a	Macular Degeneration	28343170	"miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD)."
genetics_GWAS	hsa-let-7b	Macular Degeneration	28343170	"miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD)."
genetics_GWAS	hsa-let-7d	Macular Degeneration	28343170	"miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD)."
genetics_GWAS	hsa-mir-146a	Macular Degeneration	28343170	"miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD)."
genetics_GWAS	hsa-mir-155	Macular Degeneration	28343170	"miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD)."
genetics_GWAS	hsa-mir-101	"Carcinoma, Hepatocellular"	28366737	miRNA-101-1 and miRNA-221 expressions and their polymorphisms as biomarkers for early diagnosis of hepatocellular carcinoma.
genetics_GWAS	hsa-mir-221	"Carcinoma, Hepatocellular"	28366737	miRNA-101-1 and miRNA-221 expressions and their polymorphisms as biomarkers for early diagnosis of hepatocellular carcinoma.
genetics_GWAS	hsa-mir-4293	"Carcinoma, Lung, Non-Small-Cell"	28410417	Genetic variant of miR-4293 rs12220909 is associated with susceptibility to non-small cell lung cancer in a Chinese Han population.
genetics_GWAS	hsa-mir-423	Neoplasms [unspecific]	28430524	miRNA-Related Polymorphisms in miR-423 (rs6505162) and PEX6 (rs1129186) and Risk of Esophageal Squamous Cell Carcinoma in an Iranian Cohort.
genetics_GWAS	hsa-mir-122	"Carcinoma, Hepatocellular"	28512857	Interest of variations in microRNA-152 and -122 in a series of hepatocellular carcinomas related to hepatitis C virus infection.
genetics_GWAS	hsa-mir-149	Gastric Neoplasms	28523307	miR-149 rs2292832 C>T polymorphism and risk of gastric cancer.
genetics_GWAS	hsa-mir-608	"Carcinoma, Colon"	28653886	The miR-608 rs4919510 polymorphism may modify cancer susceptibility based on type.
genetics_GWAS	hsa-mir-146a	Melanoma	28654546	Sex-specific effect of RNASEL rs486907 and miR-146a rs2910164 polymorphisms' interaction as a susceptibility factor for melanoma skin cancer.
genetics_GWAS	hsa-mir-146a	Atherosclerosis	28674224	Association of NFKB1A and microRNAs variations and the susceptibility to atherosclerosis.
genetics_GWAS	hsa-mir-181a	Neuroinflammation	28769921	MicroRNA-181 Variants Regulate T Cell Phenotype in the Context of Autoimmune Neuroinflammation
genetics_GWAS	hsa-mir-181b	Neuroinflammation	28769921	MicroRNA-181 Variants Regulate T Cell Phenotype in the Context of Autoimmune Neuroinflammation.
genetics_GWAS	hsa-mir-146a	Thyroid Neoplasms	28899898	The rs2910164 variant in MIR146A is significantly associated with DTC
genetics_GWAS	hsa-mir-149	"Squamous Cell Carcinoma, Oral"	29103762	miRNA genetic variants: As potential diagnostic biomarkers for oral cancer.
genetics_GWAS	hsa-mir-146a	Lung Neoplasms	29127520	MiR-146a rs2910164 polymorphism might be associated with the susceptibility to lung cancer and nasopharyngeal carcinoma
genetics_GWAS	hsa-mir-146a	Nasopharyngeal Neoplasms	29127520	MiR-146a rs2910164 polymorphism might be associated with the susceptibility to lung cancer and nasopharyngeal carcinoma
genetics_GWAS	hsa-mir-122	Stroke	29145255	Functional polymorphism rs3783553 in the 3'-untranslated region of IL-1A increased the risk of ischemic stroke
genetics_GWAS	hsa-mir-196a	Crohn Disease	29152405	"Association of miR-146 rs2910164, miR-196a rs11614913, miR-221 rs113054794 and miR-224 rs188519172 polymorphisms with anti-TNF treatment response in a Greek population with Crohn's disease"
genetics_GWAS	hsa-let-7i	"Squamous Cell Carcinoma, Cerevial"	29154871	Association between genetic polymorphisms in the promoters of let-7 and risk of cervical squamous cell carcinoma
genetics_GWAS	hsa-mir-146a	Creutzfeldt-Jakob Disease	29216791	The associations of two SNPs in miRNA-146a and one SNP in ZBTB38-RASA2 with the disease susceptibility and the clinical features of the Chinese patients of sCJD and FFI.
genetics_GWAS	hsa-mir-126	Myocardial Infarction	29304813	The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population
genetics_GWAS	hsa-mir-98	Osteoporosis	29307778	Computational and functional characterization of four SNPs in the SOST locus associated with osteoporosis
genetics_GWAS	hsa-mir-423	Colorectal Carcinoma	29419695	Association of microRNA-423 rs6505162 C>A polymorphism with susceptibility and metastasis of colorectal carcinoma.
genetics_GWAS	hsa-mir-146a	Bladder Neoplasms	29491365	"miR-146a rs2910164 polymorphism is a risk factor for urological neoplasms, particularly for bladder cancer"
genetics_GWAS	hsa-mir-6720	Lymphedema	29511529	"rs121909106 and rs121909107 were predicted to have the most harmful effects, while hsa-miR-6886-5p, hsa-miR-6886-5p and hsa-miR-6720-3p were predicted to be the most important miRNAs affected"
genetics_GWAS	hsa-mir-6886	Lymphedema	29511529	"rs121909106 and rs121909107 were predicted to have the most harmful effects, while hsa-miR-6886-5p, hsa-miR-6886-5p and hsa-miR-6720-3p were predicted to be the most important miRNAs affected"
genetics_GWAS	hsa-mir-146a	Breast Neoplasms	29521182	"Effects of miR-27a, miR-196a2 and miR-146a polymorphisms on the risk of breast cancer"
genetics_GWAS	hsa-mir-196a-2	Breast Neoplasms	29521182	"Effects of miR-27a, miR-196a2 and miR-148a polymorphisms on the risk of breast cancer"
genetics_GWAS	hsa-mir-27a	Breast Neoplasms	29521182	"Effects of miR-27a, miR-196a2 and miR-147a polymorphisms on the risk of breast cancer"
genetics_GWAS	hsa-mir-556	"Carcinoma, Renal Cell, Clear-Cell"	29569387	A novel functional polymorphism of GSTM3 reduces clear cell renal cell carcinoma risk through enhancing its expression by interfering miR-556 binding.
genetics_GWAS	hsa-mir-146a	Psoriasis	29587639	"A single nucleotide polymorphism in the miR-146a gene (rs2910164), aberrantly alters its gene expression and linked with the pathogenesis of several disorders, including psoriasis and PsA"
genetics_GWAS	hsa-mir-146a	Psoriatic Arthritis	29587639	"A single nucleotide polymorphism in the miR-146a gene (rs2910164), aberrantly alters its gene expression and linked with the pathogenesis of several disorders, including psoriasis and PsA"
genetics_GWAS	hsa-mir-1302	Infertility	29627965	Association of T/A polymorphism in miR-1302 binding site in CGA gene with male infertility in Isfahan population.
genetics_GWAS	hsa-mir-146a	Polycystic Ovarian Syndrome	29637801	"women with miR-146a variation are at a higher risk for developing PCOS, which can be due to up-regulation of miR-146a"
genetics_GWAS	hsa-mir-196a-2	"Squamous Cell Carcinoma, Head and Neck"	29705927	"Single nucleotide polymorphism rs11614913 associated with CC genotype in miR-196a2 is overrepresented in laryngeal squamous cell carcinoma, but not salivary gland tumors in Polish population."
genetics_GWAS	hsa-mir-146a	Colorectal Carcinoma	29715515	Hsa-mir-149C/T rs2292832 and hsa-mir-146a G/C rs2910164 may influence CRC risk in an ethnicity-dependent manner by interfering with CRC progression parameters in Tunisian cohort
genetics_GWAS	hsa-mir-149	Colorectal Carcinoma	29715515	Hsa-mir-149C/T rs2292832 and hsa-mir-146a G/C rs2910164 may influence CRC risk in an ethnicity-dependent manner by interfering with CRC progression parameters in Tunisian cohort
genetics_GWAS	hsa-mir-149	Charcot-Marie-Tooth Disease Type 1A	29729827	Association of miR-149 polymorphism with onset age and severity in Charcot-Marie-Tooth disease type 1A.
genetics_GWAS	hsa-mir-218	Neuroblastoma	29858046	the miR-34b/c rs4938723?T > C and miR-218 rs11134527 A > G polymorphisms displayed a protective role from neuroblastoma
genetics_GWAS	hsa-mir-34b	Neuroblastoma	29858046	the miR-34b/c rs4938723?T > C and miR-218 rs11134527 A > G polymorphisms displayed a protective role from neuroblastoma
genetics_GWAS	hsa-mir-34c	Neuroblastoma	29858046	the miR-34b/c rs4938723?T > C and miR-218 rs11134527 A > G polymorphisms displayed a protective role from neuroblastoma
genetics_GWAS	hsa-mir-124-1	Gastric Neoplasms	29938592	Influence of single nucleotide polymorphisms in pri-miR-124-1 and STAT3 genes on gastric cancer susceptibility.
genetics_GWAS	hsa-mir-499	"Carcinoma, Hepatocellular"	29946268	"miR-499 rs3746444 is associated with susceptibility of cervical squamous cell carcinoma, lung cancer, prostate cancer, and hepatocellular carcinoma"
genetics_GWAS	hsa-mir-499	Lung Neoplasms	29946268	"miR-499 rs3746444 is associated with susceptibility of cervical squamous cell carcinoma, lung cancer, prostate cancer, and hepatocellular carcinoma"
genetics_GWAS	hsa-mir-499	Prostate Neoplasms	29946268	"miR-499 rs3746444 is associated with susceptibility of cervical squamous cell carcinoma, lung cancer, prostate cancer, and hepatocellular carcinoma"
genetics_GWAS	hsa-mir-499	"Squamous Cell Carcinoma, Cerevial"	29946268	"miR-499 rs3746444 is associated with susceptibility of cervical squamous cell carcinoma, lung cancer, prostate cancer, and hepatocellular carcinoma"
genetics_GWAS	hsa-mir-499	"Carcinoma, Hepatocellular"	29970712	MiR-499 rs3746444 polymorphism and hepatocellular carcinoma risk: A meta-analysis.
genetics_GWAS	hsa-mir-146a	Prostate Neoplasms	30001553	"Polymorphisms of miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs3746444 may contribute to the risk for developing prostate cancer in Asian descendants"
genetics_GWAS	hsa-mir-196a	Prostate Neoplasms	30001553	"Polymorphisms of miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs3746444 may contribute to the risk for developing prostate cancer in Asian descendants"
genetics_GWAS	hsa-mir-499	Prostate Neoplasms	30001553	"Polymorphisms of miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs3746444 may contribute to the risk for developing prostate cancer in Asian descendants"
genetics_GWAS	hsa-mir-122	Hepatitis C Virus Infection	30053137	"miR-122, small RNA annealing and sequence mutations alter the predicted structure of the Hepatitis C virus 5' UTR RNA to stabilize and promote viral RNA accumulation."
genetics_GWAS	hsa-mir-146a	Lung Neoplasms	30069329	"We found that an allele carriers of miR-146a rs2910164 (P=0.022, OR=1.315) and C allele carriers of miR-149 rs71428439 (P=0.042, OR=1.372) performance a high risk of lung cancer"
genetics_GWAS	hsa-mir-149	Lung Neoplasms	30069329	"We found that an allele carriers of miR-146a rs2910164 (P=0.022, OR=1.315) and C allele carriers of miR-149 rs71428439 (P=0.042, OR=1.372) performance a high risk of lung cancer"
genetics_GWAS	hsa-mir-499	Congenital Heart Diseases	30084801	Association of a MiR-499 SNP and risk of congenital heart disease in a Chinese population.
genetics_GWAS	hsa-mir-499	Cardiovascular Diseases [unspecific]	30102014	A polymorphism rs3746444 within the pre-miR-499 alters the maturation of miR-499-5p and its antiapoptotic function.
genetics_GWAS	hsa-mir-218	"Squamous Cell Carcinoma, Esophageal"	30120974	Association between miR-218 rs11134527 polymorphism and risk of selected types of cancer in Asian population: An updated meta-analysis of case-control studies.
genetics_GWAS	hsa-mir-125a	"Carcinoma, Breast"	30135399	"Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population."
genetics_GWAS	hsa-mir-146a	"Carcinoma, Breast"	30135399	"Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population."
genetics_GWAS	hsa-mir-182	"Carcinoma, Breast"	30135399	"Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population."
genetics_GWAS	hsa-mir-499	"Carcinoma, Breast"	30135399	"Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population."
genetics_GWAS	hsa-mir-605	"Carcinoma, Breast"	30135399	"Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population."
genetics_GWAS	hsa-mir-3161	Glaucoma	30148417	"MicroRNA-related polymorphisms in pseudoexfoliation syndrome, pseudoexfoliative glaucoma, and primary open-angle glaucoma."
genetics_GWAS	hsa-mir-21	Atherosclerosis	30205366	rs145204276 was associated with the risk of atherosclerosis by affecting the proliferation and apoptosis of endothelial cells via regulating the GAS5/miR-21/PDCD4 signaling pathway
genetics_GWAS	hsa-mir-499	"Stroke, Ischemic"	30229913	hsa-mir-499 rs3746444 A/G polymorphism may be associated with a significantly increased risk of IS in an Iranian population
genetics_GWAS	hsa-mir-34a	Gastric Neoplasms	30242897	Minor allele of rs1057317 polymorphism in TLR4 is associated with increased risk of Helicobacter pylori -induced gastric cancer.
genetics_GWAS	hsa-mir-146a	"Stroke, Ischemic"	30254431	the GG genotype of miR-146a (rs2910164) and CC genotype of miR-149 (rs2292832) may confer increased susceptibility to IS
genetics_GWAS	hsa-mir-149	"Stroke, Ischemic"	30254431	the GG genotype of miR-146a (rs2910164) and CC genotype of miR-149 (rs2292832) may confer increased susceptibility to IS
genetics_GWAS	hsa-mir-300	Lung Neoplasms	30271206	miR-300 rs12894467 polymorphism may be associated with susceptibility to primary lung cancer in the Chinese Han population.
genetics_GWAS	hsa-mir-149	Gastric Neoplasms	30274913	Association Between miR-149 Gene rs2292832 Polymorphism and Risk of Gastric Cancer: A Case-control Study.
genetics_GWAS	hsa-mir-146a	"Colitis, Ulcerative"	30278502	Association of miRNA-146a rs2910164 and miRNA-196 rs11614913 polymorphisms in patients with ulcerative colitis: A meta-analysis and review.
genetics_GWAS	hsa-mir-196a	"Colitis, Ulcerative"	30278502	Association of miRNA-146a rs2910164 and miRNA-196 rs11614913 polymorphisms in patients with ulcerative colitis: A meta-analysis and review.
genetics_GWAS	hsa-mir-423	Coronary Artery Disease	30289085	Potential impact of microRNA-423 gene variability in coronary artery disease.
genetics_GWAS	hsa-mir-125a	"Carcinoma, Lung"	30302847	Regulation of miR-125a expression by rs12976445 single-nucleotide polymorphism?is associated with radiotherapy-induced pneumonitis in lung carcinoma patients.
genetics_GWAS	hsa-mir-589	Cataract	30315181	luciferase reporter gene expression can be down regulated by hsa-miR-589-5p in cells transfected with rs2229090 C allele compared to G allele
genetics_GWAS	hsa-mir-579	Anxiety Disorders	30341278	A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety.
genetics_GWAS	hsa-mir-21	Inflammation	30375257	Cigarette smoking affects microRNAs and inflammatory biomarkers in healthy individuals and an association to single nucleotide polymorphisms is indicated.
genetics_knock down_promote	hsa-mir-15a	Leukemia	12434020	deletion or downregulation
genetics_knock down_promote	hsa-mir-15a	"Leukemia, Lymphocytic, Chronic, B-Cell"	12434020	deletion or downregulation
genetics_knock down_promote	hsa-mir-16-1	Leukemia	12434020	deletion or downregulation
genetics_knock down_promote	hsa-mir-16-1	"Leukemia, Lymphocytic, Chronic, B-Cell"	12434020	deletion or downregulation
genetics_knock down_promote	hsa-mir-125b-1	Breast Neoplasms	14973191	deletion
genetics_knock down_promote	hsa-mir-125b-1	Lung Neoplasms	14973191	deletion
genetics_knock down_promote	hsa-mir-125b-1	Ovarian Neoplasms	14973191	deletion
genetics_knock down_promote	hsa-mir-125b-1	Urinary Bladder Cancer	14973191	deletion
genetics_knock down_promote	hsa-mir-17	"Carcinoma, Hepatocellular"	15944709	loss of heterozygosity of this cluster
genetics_knock down_promote	hsa-mir-18a	"Carcinoma, Hepatocellular"	15944709	loss of heterozygosity of this cluster
genetics_knock down_promote	hsa-mir-19a	"Carcinoma, Hepatocellular"	15944709	loss of heterozygosity of this cluster
genetics_knock down_promote	hsa-mir-19b-1	"Carcinoma, Hepatocellular"	15944709	loss of heterozygosity of this cluster
genetics_knock down_promote	hsa-mir-20a	"Carcinoma, Hepatocellular"	15944709	loss of heterozygosity of this cluster
genetics_knock down_promote	hsa-mir-125b-1	"Leukemia-Lymphoma, Precursor B-Cell Lymphoblastic"	16151463	an insertion of pre-miRNA into the immunoglobulin heavy-chain locus
genetics_knock down_promote	hsa-mir-15a	Leukemia	16166262	the deletion or downregulation of mir-15a results in increased expression of BCL2.
genetics_knock down_promote	hsa-mir-15a	Lymphoma	16166262	the deletion or downregulation of mir-15a results in increased expression of BCL2.
genetics_knock down_promote	hsa-mir-16-1	Leukemia	16166262	the deletion or downregulation of mir-15a results in increased expression of BCL2.
genetics_knock down_promote	hsa-mir-16-1	Lymphoma	16166262	the deletion or downregulation of mir-15a results in increased expression of BCL2.
genetics_knock down_promote	hsa-mir-125b-1	"Leukemia, B-Cell"	16885332	"In a precursor B-cell acute lymphoblastic leukemia, an insertion of miR-125b-1 into a rearranged immunoglobulin heavy chain locus was described."
genetics_knock down_promote	hsa-mir-142	"Leukemia, B-Cell"	16885332	It was shown later that miR-142 is located at the chromosome 17 breakpoint and that c-Myc was rearranged under the control of the promoter of miR-142 with consequent overexpression.
genetics_knock down_promote	hsa-mir-15a	"Leukemia, B-Cell"	16885332	Deleted and down-regulated in the majority of B-CLLs
genetics_knock down_promote	hsa-mir-15a	Pituitary Neoplasms	16885332	a type of benign tumors displaying deletions at 13q14.3 and reduced expression of miR-16-1 and miR-15a
genetics_knock down_promote	hsa-mir-16-1	"Leukemia, B-Cell"	16885332	Deleted and down-regulated in the majority of B-CLLs
genetics_knock down_promote	hsa-mir-16-1	Pituitary Neoplasms	16885332	a type of benign tumors displaying deletions at 13q14.3 and reduced expression of miR-16-1 and miR-15a
genetics_knock down_promote	hsa-mir-17	Breast Neoplasms	16940181	"The genomic location of Mir-17-5p also undergoesloss of heterozygosity in different types of cancer, including breast cancer."
genetics_knock down_promote	hsa-mir-92a-1	Hematologic Neoplasms	17011485	The miR-17-92 cluster is amplified in hematopoietic malignancies.
genetics_knock down_promote	hsa-mir-15a	Breast Neoplasms	17012848	"Later on, deletion of mir-16-1 and mir-15a deletion were also identified in epithelial tumors, such as pituitary adenomas, ovarian and breast cancer."
genetics_knock down_promote	hsa-mir-15a	"Leukemia, Lymphocytic, Chronic, B-Cell"	17012848	"It was found that mir-16-1 and mir-15a at 13q14 are deleted in more than 50% patients, with concurrent reduced expression in ~65% patients. Further studies demonstrated that these two miRNAs suppress BCL2 expression and may serve as tumor suppressor genes in this disease."
genetics_knock down_promote	hsa-mir-16-1	"Leukemia, Lymphocytic, Chronic, B-Cell"	17012848	"It was found that mir-16-1 and mir-15a at 13q14 are deleted in more than 50% patients, with concurrent reduced expression in ~65% patients. Further studies demonstrated that these two miRNAs suppress BCL2 expression and may serve as tumor suppressor genes in this disease."
genetics_knock down_promote	hsa-mir-16-1	Ovarian Neoplasms	17012848	"Later on, deletion of mir-16-1 and mir-15a deletion were also identified in epithelial tumors, such as pituitary adenomas, ovarian and breast cancer."
genetics_knock down_promote	hsa-mir-16-1	Pituitary Neoplasms	17012848	"Later on, deletion of mir-16-1 and mir-15a deletion were also identified in epithelial tumors, such as pituitary adenomas, ovarian and breast cancer."
genetics_knock down_promote	hsa-mir-125b-1	"Leukemia, B-Cell"	17028302	"It is of note that insertion of miR-125b-1 into a rearranged immunoglobulin heavy chain gene locus was recently reported in a patient with precursor B-cell acute lymphoblastic leukemia, though the expression miR-125b-1 was not investigated."
genetics_knock down_promote	hsa-mir-15a	"Leukemia, Lymphocytic, Chronic, B-Cell"	17028302	"Detailed analyses of deletion and expression status revealed these two miRNAs to be located within a 30 kb minimally deleted region in chronic lymphocytic leukemia (CLL) patients, both of which were deleted or downregulated in most CLL cases, suggesting that miR-15a and miR-16-1 may function as tumor suppressor genes."
genetics_knock down_promote	hsa-mir-16-1	"Leukemia, Lymphocytic, Chronic, B-Cell"	17028302	"Detailed analyses of deletion and expression status revealed these two miRNAs to be located within a 30 kb minimally deleted region in chronic lymphocytic leukemia (CLL) patients, both of which were deleted or downregulated in most CLL cases, suggesting that miR-15a and miR-16-1 may function as tumor suppressor genes."
genetics_knock down_promote	hsa-mir-199a-1	"Carcinoma, Hepatocellular"	17188425	"This region encodes miRNA-199a-1 (19p13.2), whose expression levels are lower in HCC compared to nontumor liver [59] and is deleted in several other tumor types."
genetics_knock down_promote	hsa-mir-15a	"Leukemia, Lymphocytic, Chronic, B-Cell"	17234972	"After years of futile attemptsto identify the gene(s) in the deleted 13q14 region that participatein the pathogenesis of chronic lymphocytic leukemia, Calin etal discovered that miR-15 and miR-16 are located within thissequence and that both are downregulated in 68% of cases."
genetics_knock down_promote	hsa-mir-15b	"Leukemia, Lymphocytic, Chronic, B-Cell"	17234972	"After years of futile attemptsto identify the gene(s) in the deleted 13q14 region that participatein the pathogenesis of chronic lymphocytic leukemia, Calin etal discovered that miR-15 and miR-16 are located within thissequence and that both are downregulated in 68% of cases."
genetics_knock down_promote	hsa-mir-16-1	"Leukemia, Lymphocytic, Chronic, B-Cell"	17234972	"After years of futile attemptsto identify the gene(s) in the deleted 13q14 region that participatein the pathogenesis of chronic lymphocytic leukemia, Calin etal discovered that miR-15 and miR-16 are located within thissequence and that both are downregulated in 68% of cases."
genetics_knock down_promote	hsa-mir-16-2	"Leukemia, Lymphocytic, Chronic, B-Cell"	17234972	"After years of futile attemptsto identify the gene(s) in the deleted 13q14 region that participatein the pathogenesis of chronic lymphocytic leukemia, Calin etal discovered that miR-15 and miR-16 are located within thissequence and that both are downregulated in 68% of cases."
genetics_knock down_promote	hsa-mir-181b-2	Urinary Bladder Cancer	17470785	"mir-181b-2 and mir-199b are 3.3 Mb from the peak of the colon Scc2 locus on Chr 2; homologous human miRNAs are located inside a cancer-associated genomic region, which is a region commonly deleted in bladder cancer."
genetics_knock down_promote	hsa-mir-199b	Urinary Bladder Cancer	17470785	"mir-181b-2 and mir-199b are 3.3 Mb from the peak of the colon Scc2 locus on Chr 2; homologous human miRNAs are located inside a cancer-associated genomic region, which is a region commonly deleted in bladder cancer."
genetics_knock down_promote	hsa-mir-15a	"Leukemia, Lymphocytic, Chronic, B-Cell"	17531469	"The loss-of-function of miR-15a and miR-16-1 in CLL, and perhaps other cancers as well, may contribute to malignant transformation by upregulating Bcl2 thereby preventing apoptosis."
genetics_knock down_promote	hsa-mir-16-1	"Leukemia, Lymphocytic, Chronic, B-Cell"	17531469	"the loss-of-function of miR-15a and miR-16-1 in CLL, and perhaps other cancers as well, may contribute to malignant transformation by upregulating Bcl2 thereby preventing apoptosis."
genetics_knock down_promote	hsa-mir-15a	"Leukemia, Lymphocytic, Chronic, B-Cell"	17940623	"The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells."
genetics_knock down_promote	hsa-mir-15a	"Lymphoma, Mantle-Cell"	17940623	"The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells."
genetics_knock down_promote	hsa-mir-15a	Multiple Myeloma	17940623	"The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells."
genetics_knock down_promote	hsa-mir-15a	Prostate Neoplasms	17940623	"The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells."
genetics_knock down_promote	hsa-mir-16-1	"Leukemia, Lymphocytic, Chronic, B-Cell"	17940623	"The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells."
genetics_knock down_promote	hsa-mir-16-1	"Lymphoma, Mantle-Cell"	17940623	"The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells."
genetics_knock down_promote	hsa-mir-16-1	Multiple Myeloma	17940623	"The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells."
genetics_knock down_promote	hsa-mir-16-1	Prostate Neoplasms	17940623	"The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells."
genetics_knock down_promote	hsa-mir-15a	"Leukemia, Lymphocytic, Chronic, B-Cell"	17965831	"miR-15a and miR-16 are often deleted from chromosome 13q14.2 in patients with B cell CLL, suggesting that these miRNAs may be involved in tumour suppression. Additionally, introduction of exogenous miR-16 into a malignant B-1 cell line resulted in increased apoptosis."
genetics_knock down_promote	hsa-mir-16-1	"Leukemia, Lymphocytic, Chronic, B-Cell"	17965831	"miR-15a and miR-16 are often deleted from chromosome 13q14.2 in patients with B cell CLL, suggesting that these miRNAs may be involved in tumour suppression. Additionally, introduction of exogenous miR-16 into a malignant B-1 cell line resulted in increased apoptosis."
genetics_knock down_promote	hsa-mir-16-2	"Leukemia, Lymphocytic, Chronic, B-Cell"	17965831	"miR-15a and miR-16 are often deleted from chromosome 13q14.2 in patients with B cell CLL, suggesting that these miRNAs may be involved in tumour suppression. Additionally, introduction of exogenous miR-16 into a malignant B-1 cell line resulted in increased apoptosis."
genetics_knock down_promote	hsa-mir-29a	Alzheimer Disease	18434550	loss
genetics_knock down_promote	hsa-mir-29b-1	Alzheimer Disease	18434550	loss
genetics_knock down_promote	hsa-mir-1-1	"Carcinoma, Hepatocellular"	18593903	miR-1: silenced
genetics_knock down_promote	hsa-mir-1-2	"Carcinoma, Hepatocellular"	18593903	miR-1: silenced
genetics_knock down_promote	hsa-mir-34a	Neoplasms [unspecific]	18834855	miR-34a: reduced or lost
genetics_knock down_promote	hsa-mir-101-1	Neoplasms [unspecific]	19008416	miR-101: Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
genetics_knock down_promote	hsa-mir-101-2	Neoplasms [unspecific]	19008416	miR-101: Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
genetics_knock down_promote	hsa-mir-31	Neoplasms [unspecific]	20179198	miR-31 is associated with defects in the p53 pathway and functions in serous ovarian cancer and other cancers
genetics_knock down_promote	hsa-mir-31	Ovarian Neoplasms	20179198	miR-31 is associated with defects in the p53 pathway and functions in serous ovarian cancer and other cancers
genetics_knock down_promote	hsa-mir-143	Neoplasms [unspecific]	20439436	miR-143:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted
genetics_knock down_promote	hsa-mir-145	Neoplasms [unspecific]	20439436	miR-145:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted
genetics_knock down_promote	hsa-mir-31	Mesothelioma	20463022	miR-31:Pro-tumorigenic effects of miR-31 loss in mesothelioma
genetics_knock down_promote	hsa-mir-301a	Lung Neoplasms	20470754	"miR-301:blocking of miR-301 in A549 cells leads to a decrease in the expression of the host gene, ska2"
genetics_knock down_promote	hsa-mir-29a	"Leukemia, Myeloid, Acute"	20628397	miR-29a:The tumour-suppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML
genetics_knock down_promote	hsa-mir-29b-1	"Leukemia, Myeloid, Acute"	20628397	miR-29b1:The tumour-suppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML
genetics_knock down_promote	hsa-mir-15a	"Leukemia, Lymphocytic, Chronic, B-Cell"	21156224	often absent
genetics_knock down_promote	hsa-mir-16-1	"Leukemia, Lymphocytic, Chronic, B-Cell"	21156224	often absent
genetics_knock down_promote	hsa-mir-107	Urinary Bladder Cancer	21388952	Specific deletion of p53 in urothelial cells is associated with specific overexpression of miR-18a and miR-19a and down-regulation of miR-107.
genetics_knock down_promote	hsa-mir-486	Gastric Neoplasms	21415212	Genomic Loss of miR-486 Regulates Tumor Progression and the OLFM4 Anti-apoptotic Factor in Gastric Cancer.
genetics_knock down_promote	hsa-mir-15a	Prostate Neoplasms	21472816	The miR-15a-miR-16-1 locus is homozygously deleted in a subset of prostate cancers.
genetics_knock down_promote	hsa-mir-16-1	Prostate Neoplasms	21472816	The miR-15a-miR-16-1 locus is homozygously deleted in a subset of prostate cancers.
genetics_knock down_promote	hsa-mir-218-1	Urinary Bladder Cancer	21519788	miR-218 on the genomic loss region of chromosome 4p15.31 functions as a tumor suppressor in bladder cancer.
genetics_knock down_promote	hsa-mir-218-2	Urinary Bladder Cancer	21519788	miR-218 on the genomic loss region of chromosome 4p15.31 functions as a tumor suppressor in bladder cancer.
genetics_knock down_promote	hsa-mir-1-1	Myotonic Muscular Dystrophy	21685920	"As a consequence of miR-1 loss, expression of GJA1 (connexin 43) and CACNA1C (Cav1.2), which are targets of miR-1, is increased in both DM1- and DM2-affected hearts."
genetics_knock down_promote	hsa-mir-1-2	Myotonic Muscular Dystrophy	21685920	"As a consequence of miR-1 loss, expression of GJA1 (connexin 43) and CACNA1C (Cav1.2), which are targets of miR-1, is increased in both DM1- and DM2-affected hearts."
genetics_knock down_promote	hsa-mir-135a-1	Medulloblastoma	21793975	deletion
genetics_knock down_promote	hsa-mir-135a-2	Medulloblastoma	21793975	deletion or amplification
genetics_knock down_promote	hsa-mir-135b	Medulloblastoma	21793975	deletion or amplification
genetics_knock down_promote	hsa-mir-186	Medulloblastoma	21793975	deletion
genetics_knock down_promote	hsa-mir-33b	Medulloblastoma	21793975	"deletion, amplification or a mutation at the precursor miRNA"
genetics_knock down_promote	hsa-mir-512-2	Medulloblastoma	21793975	"deletion. Antisense-based knockdown of miR-512-5p (mature sequence of miR-512-2) resulted in significant upregulation of MYCC expression in HeLa and A549 cells, while forced overexpression of miR-512-2 in medulloblastoma/PNET cell lines DAOY, UW-228-2, PFSK resulted in downregulation of MYCC protein."
genetics_knock down_promote	hsa-mir-548d-1	Medulloblastoma	21793975	deletion
genetics_knock down_promote	hsa-mir-548d-2	Medulloblastoma	21793975	deletion
genetics_knock down_promote	hsa-mir-132	Progressive Supranuclear Palsy	21807765	"MicroRNA-132 loss is associated with tau exon 10 inclusion in Supranuclear Palsy, Progressive."
genetics_knock down_promote	hsa-mir-101-1	Lung Neoplasms	21849855	miR-101 DNA Copy Loss is a Prominent Subtype Specific Event in Lung Cancer.
genetics_knock down_promote	hsa-mir-101-2	Lung Neoplasms	21849855	miR-101 DNA Copy Loss is a Prominent Subtype Specific Event in Lung Cancer.
genetics_knock down_promote	hsa-mir-145	Myelodysplastic Syndromes	21873545	miR-145 affects megakaryocyte and erythroid differentiation.Patients with del(5q) MDS have decreased expression of miR-145 and increased expression of Fli-1. Combined loss of miR-145 and RPS14 cooperate to alter erythroid-megakaryocytic differentiation in a manner similar to the 5q- syndrome.
genetics_knock down_promote	hsa-mir-17	Musculoskeletal Abnormalities [unspecific]	21892160	Germline deletion of the miR-17-92 cluster causes skeletal and growth defects in humans.
genetics_knock down_promote	hsa-mir-18a	Musculoskeletal Abnormalities [unspecific]	21892160	Germline deletion of the miR-17-92 cluster causes skeletal and growth defects in humans.
genetics_knock down_promote	hsa-mir-19a	Musculoskeletal Abnormalities [unspecific]	21892160	Germline deletion of the miR-17-92 cluster causes skeletal and growth defects in humans.
genetics_knock down_promote	hsa-mir-19b-1	Musculoskeletal Abnormalities [unspecific]	21892160	Germline deletion of the miR-17-92 cluster causes skeletal and growth defects in humans.
genetics_knock down_promote	hsa-mir-20a	Musculoskeletal Abnormalities [unspecific]	21892160	Germline deletion of the miR-17-92 cluster causes skeletal and growth defects in humans.
genetics_knock down_promote	hsa-mir-92a-1	Musculoskeletal Abnormalities [unspecific]	21892160	Germline deletion of the miR-17-92 cluster causes skeletal and growth defects in humans.
genetics_knock down_promote	hsa-mir-21	Hypertension	21920918	"Induction of miR-21 and miR-27a may be a critical component of BMP-induced growth suppression, loss of which likely contributes to vascular cell proliferation in HPAH (Heritable pulmonary arterial hypertension)."
genetics_knock down_promote	hsa-mir-101-1	Pancreatic Neoplasms	21932133	Loss of MicroRNA-101 Promotes Overexpression of Histone Methyltransferase EZH2.
genetics_knock down_promote	hsa-mir-101-2	Pancreatic Neoplasms	21932133	Loss of MicroRNA-101 Promotes Overexpression of Histone Methyltransferase EZH2.
genetics_knock down_promote	hsa-mir-101-1	"Carcinoma, Lung, Non-Small-Cell"	21993632	"Down-regulation of miR-101 was associated with overexpression of Mcl-1 mRNA in NSCLC tissue when compared with corresponding normal tissue, with a negative correlation (r = -0.724, P < 0.01). MiR-101 expression was significantly associated with pathological stage (P = 0.004) and lymph node involvement (P = 0.012). Overexpression of Mcl-1 was associated with pathological grade (P = 0.022) and lymph node involvement (P = 0.017). A comparison of survival curves of low versus high expressers of miR-101 and Mcl-1 revealed a highly significant difference in NSCLC (P < 0.05), which suggests that reduced expression of miR-101 versus overexpression of Mcl-1 is associated with a poorer prognosis."
genetics_knock down_promote	hsa-mir-101-2	"Carcinoma, Lung, Non-Small-Cell"	21993632	"Down-regulation of miR-101 was associated with overexpression of Mcl-1 mRNA in NSCLC tissue when compared with corresponding normal tissue, with a negative correlation (r = -0.724, P < 0.01). MiR-101 expression was significantly associated with pathological stage (P = 0.004) and lymph node involvement (P = 0.012). Overexpression of Mcl-1 was associated with pathological grade (P = 0.022) and lymph node involvement (P = 0.017). A comparison of survival curves of low versus high expressers of miR-101 and Mcl-1 revealed a highly significant difference in NSCLC (P < 0.05), which suggests that reduced expression of miR-101 versus overexpression of Mcl-1 is associated with a poorer prognosis."
genetics_knock down_promote	hsa-mir-144	Thyroid Neoplasms	22049245	miR-199b-5p and miR-144 which were essentially lost in the carcinomas.
genetics_knock down_promote	hsa-mir-199b	Thyroid Neoplasms	22049245	miR-199b-5p and miR-144 which were essentially lost in the carcinomas.
genetics_knock down_promote	hsa-mir-29a	Kidney Diseases [unspecific]	22095944	Suppression of microRNA-29 Expression by TGF-beta1 Promotes Collagen Expression and Renal Fibrosis.
genetics_knock down_promote	hsa-mir-29b-1	Kidney Diseases [unspecific]	22095944	Suppression of microRNA-29 Expression by TGF-beta1 Promotes Collagen Expression and Renal Fibrosis.
genetics_knock down_promote	hsa-mir-29b-2	Kidney Diseases [unspecific]	22095944	Suppression of microRNA-29 Expression by TGF-beta1 Promotes Collagen Expression and Renal Fibrosis.
genetics_knock down_promote	hsa-mir-29c	Kidney Diseases [unspecific]	22095944	Suppression of microRNA-29 Expression by TGF-beta1 Promotes Collagen Expression and Renal Fibrosis.
genetics_knock down_promote	hsa-mir-122	Hepatitis B Virus Infection	22105316	Loss of MiR-122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1 modulated P53 activity.
genetics_knock down_promote	hsa-mir-34a	Rheumatoid Arthritis	22161761	Downregulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance.
genetics_knock down_promote	hsa-mir-124-1	Glioma	22253443	Loss of brain-enriched miR-124 enhances the stem-like traits and invasiveness of glioma cells.
genetics_knock down_promote	hsa-mir-124-2	Glioma	22253443	Loss of brain-enriched miR-124 enhances the stem-like traits and invasiveness of glioma cells.
genetics_knock down_promote	hsa-mir-124-3	Glioma	22253443	Loss of brain-enriched miR-124 enhances the stem-like traits and invasiveness of glioma cells.
genetics_knock down_promote	hsa-mir-145	Ovarian Neoplasms	22285623	The loss of miR-145 can result in the activation of factors that promote oncogenesis and cellular pluripotency which in turn could lead to the development of ovarian cancer.
genetics_knock down_promote	hsa-mir-133a-1	Breast Neoplasms	22292984	Loss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion.
genetics_knock down_promote	hsa-mir-133a-2	Breast Neoplasms	22292984	Loss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion.
genetics_knock down_promote	hsa-mir-29a	"Muscular Dystrophy, Duchenne"	22434133	Loss of miR-29 in Myoblasts Contributes to Dystrophic Muscle Pathogenesis.
genetics_knock down_promote	hsa-mir-29b-1	"Muscular Dystrophy, Duchenne"	22434133	Loss of miR-29 in Myoblasts Contributes to Dystrophic Muscle Pathogenesis.
genetics_knock down_promote	hsa-mir-29b-2	"Muscular Dystrophy, Duchenne"	22434133	Loss of miR-29 in Myoblasts Contributes to Dystrophic Muscle Pathogenesis.
genetics_knock down_promote	hsa-mir-29c	"Muscular Dystrophy, Duchenne"	22434133	Loss of miR-29 in Myoblasts Contributes to Dystrophic Muscle Pathogenesis.
genetics_knock down_promote	hsa-mir-101-1	Gastric Neoplasms	22450781	Lack of microRNA-101 causes E-cadherin functional deregulation through EZH2 upregulation in intestinal gastric cancer.
genetics_knock down_promote	hsa-let-7c	Prostate Neoplasms	22479342	MicroRNA let-7c Is Downregulated in Prostate Cancer and Suppresses Prostate Cancer Growth.
genetics_knock down_promote	hsa-mir-205	Melanoma	22525428	Loss of microRNA-205 expression is associated with melanoma progression.
genetics_knock down_promote	hsa-let-7g	Melanoma	22551973	The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors.
genetics_knock down_promote	hsa-mir-126	Pancreatic Neoplasms	22845403	Loss of miR-126 is crucial to pancreatic cancer progression.
genetics_knock down_promote	hsa-mir-148a	Endometrial Neoplasms	22890324	Silencing of miR-148a in cancer-associated fibroblasts results in WNT10B-mediated stimulation of tumor cell motility.
genetics_knock down_promote	hsa-mir-218-1	Breast Neoplasms	22898079	Silencing of miRNA-218 promotes migration and invasion of breast cancer via Slit2-Robo1 pathway.
genetics_knock down_promote	hsa-mir-218-2	Breast Neoplasms	22898079	Silencing of miRNA-218 promotes migration and invasion of breast cancer via Slit2-Robo1 pathway.
genetics_knock down_promote	hsa-mir-101-1	Colon Neoplasms	22930392	Loss of miR-101 Expression Promotes Wnt/beta-Catenin Signalling Pathway Activation and Malignancy in Colon Cancer Cells.
genetics_knock down_promote	hsa-mir-200a	Melanoma	22956368	"Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression."
genetics_knock down_promote	hsa-mir-200c	Melanoma	22956368	"Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression."
genetics_knock down_promote	hsa-mir-203	Melanoma	22956368	"Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression."
genetics_knock down_promote	hsa-mir-370	Cholangiocarcinoma	23110045	Silencing of miR-370 in human cholangiocarcinoma by allelic loss and interleukin-6 induced maternal to paternal epigenotype switch
genetics_knock down_promote	hsa-mir-126	Heart Failure	23136161	Loss of AngiomiR-126 and 130a in Angiogenic Early Outgrowth Cells From Patients With Chronic Heart Failure: Role for Impaired In Vivo Neovascularization and Cardiac Repair Capacity
genetics_knock down_promote	hsa-mir-130a	Heart Failure	23136161	Loss of AngiomiR-126 and 130a in Angiogenic Early Outgrowth Cells From Patients With Chronic Heart Failure: Role for Impaired In Vivo Neovascularization and Cardiac Repair Capacity
genetics_knock down_promote	hsa-mir-204	Glioma	23204229	Loss of miR-204 Expression Enhances Glioma Migration and Stem Cell-like Phenotype
genetics_knock down_promote	hsa-mir-132	Osteosarcoma	23801049	Loss of microRNA-132 predicts poor prognosis in patients with primary osteosarcoma.
genetics_knock down_promote	hsa-let-7	Prostate Neoplasms	23977098	"MSCs co-evolve with prostate cancer cells in the tumor microenvironment, and the downregulation of let-7 by cancer-associated MSCs upregulates IL-6 expression."
genetics_knock down_promote	hsa-mir-15a	"Leukemia, Lymphocytic, Chronic, B-Cell"	24026141	"There was a significantly decreased expression of both miRNAs in patients with biallelic deletion of the 13q14 region but only when deletions were present in 77% or more of cells, as detected by fluorescent in situ hybridization (FISH)."
genetics_knock down_promote	hsa-mir-16-1	"Leukemia, Lymphocytic, Chronic, B-Cell"	24026141	"There was a significantly decreased expression of both miRNAs in patients with biallelic deletion of the 13q14 region but only when deletions were present in 77% or more of cells, as detected by fluorescent in situ hybridization (FISH)."
genetics_knock down_promote	hsa-mir-21	Ischemia-Reperfusion Injury	24098402	Our data clearly demonstrate that miR-21 is involved in IPost-mediated cardiac protection against I/R injury and dysfunction through the PTEN/Akt signaling pathway in vivo.
genetics_knock down_promote	hsa-mir-10a	Neoplasms [unspecific]	24204315	Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice.
genetics_knock down_promote	hsa-mir-200a	Breast Neoplasms	24280074	Loss of microRNA-200a expression correlates with tumor progression in breast cancer.
genetics_knock down_promote	hsa-mir-126	Prostate Neoplasms	24350576	These findings suggest for the first time that the loss of miR-126 expression may play a positive role in the malignant progression of PCa. 
genetics_knock down_promote	hsa-mir-214	"Carcinoma, Nasopharyngeal"	24465927	Knockdown of miR-214 promotes apoptosis and inhibits cell proliferation in nasopharyngeal carcinoma.
genetics_knock down_promote	hsa-mir-223	Sepsis	24486439	"Taken together, these data indicate that loss of miR-223/-223* causes an aggravation of sepsis-induced inflammation, myocardial dysfunction and mortality."
genetics_knock down_promote	hsa-mir-206	Amyotrophic Lateral Sclerosis	24664281	"in mutant mice lacking miR-206, reinnervation is impaired following nerve injury and loss of NMJs is accelerated in a mouse model of amyotrophic lateral sclerosis (ALS)."
genetics_knock down_promote	hsa-mir-145	"Carcinoma, Hepatocellular"	24690171	"Our results demonstrated that miR-145 could inhibit HCC through targeting IRS1 and its downstream signaling, implicating the loss of miR-145 regulation may be a potential molecular mechanism causing aberrant oncogenic signaling in HCC."
genetics_knock down_promote	hsa-mir-15a	"Leukemia, Lymphocytic, Chronic, B-Cell"	24732594	Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia.
genetics_knock down_promote	hsa-mir-16-1	"Leukemia, Lymphocytic, Chronic, B-Cell"	24732594	Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia.
genetics_knock down_promote	hsa-mir-21	Pulmonary Hypertension	24732886	"In vivo, genetic deletion of microRNA-21 in mice (miR-21(-/-) mice) resulted in functional activation of the PDCD4/caspase-3 axis in the pulmonary tissues, leading to the onset of progressive PH."
genetics_knock down_promote	hsa-mir-424	Hepatoblastoma	24796297	"Furthermore, miR-424 or miR-503 depletion enhanced extravasation to the lungs of hepatocarcinoma cells injected in the tail vein of mice."
genetics_knock down_promote	hsa-mir-100	Prostate Neoplasms	24805183	"Loss of miR-100 enhances migration, invasion, epithelial-mesenchymal transition and stemness properties in prostate cancer cells through targeting Argonaute 2."
genetics_knock down_promote	hsa-mir-451a	"Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal"	24918822	Loss of tumour suppressive miR-451a enhanced cancer cell migration and invasion in HSCC through direct regulation of ESDN. Our miRNA signature and functional analysis of targets regulated by tumour suppressive miR-451a provide new insights into the potential mechanisms of HSCC oncogenesis and metastasis.
genetics_knock down_promote	hsa-mir-17	Atrial Fibrillation	24927531	"miR-17-92 and miR-106b-25 directly repress genes, such as Shox2 and Tbx3, that are required for sinoatrial node development.Together, to our knowledge, these findings provide the first genetic evidence for an miR loss-of-function that increases atrial fibrillation susceptibility."
genetics_knock down_promote	hsa-mir-18	Atrial Fibrillation	24927531	"miR-17-92 and miR-106b-25 directly repress genes, such as Shox2 and Tbx3, that are required for sinoatrial node development.Together, to our knowledge, these findings provide the first genetic evidence for an miR loss-of-function that increases atrial fibrillation susceptibility."
genetics_knock down_promote	hsa-mir-19a	Atrial Fibrillation	24927531	"miR-17-92 and miR-106b-25 directly repress genes, such as Shox2 and Tbx3, that are required for sinoatrial node development.Together, to our knowledge, these findings provide the first genetic evidence for an miR loss-of-function that increases atrial fibrillation susceptibility."
genetics_knock down_promote	hsa-mir-19b-1	Atrial Fibrillation	24927531	"miR-17-92 and miR-106b-25 directly repress genes, such as Shox2 and Tbx3, that are required for sinoatrial node development.Together, to our knowledge, these findings provide the first genetic evidence for an miR loss-of-function that increases atrial fibrillation susceptibility."
genetics_knock down_promote	hsa-mir-20a	Atrial Fibrillation	24927531	"miR-17-92 and miR-106b-25 directly repress genes, such as Shox2 and Tbx3, that are required for sinoatrial node development.Together, to our knowledge, these findings provide the first genetic evidence for an miR loss-of-function that increases atrial fibrillation susceptibility."
genetics_knock down_promote	hsa-mir-92-1	Atrial Fibrillation	24927531	"miR-17-92 and miR-106b-25 directly repress genes, such as Shox2 and Tbx3, that are required for sinoatrial node development.Together, to our knowledge, these findings provide the first genetic evidence for an miR loss-of-function that increases atrial fibrillation susceptibility."
genetics_knock down_promote	hsa-mir-203	Prostate Neoplasms	24980827	Loss of tumor suppressor mir-203 mediates overexpression of LIM and SH3 Protein 1 (LASP1) in high-risk prostate cancer thereby increasing cell proliferation and migration.
genetics_knock down_promote	hsa-mir-155	Melanoma	25143000	Our current study showed that both B16-F10 melanoma and Lewis lung carcinoma tumors grew much faster in bic/miR-155 knockout (miR-155(-/-) ) mice
genetics_knock down_promote	hsa-mir-378	Prostate Neoplasms	25153390	"Loss of miR-378 in prostate cancer, a common regulator of KLK2 and KLK4, correlates with aggressive disease phenotype and predicts the short-term relapse of the patients."
genetics_knock down_promote	hsa-mir-100	"Carcinoma, Hepatocellular"	25361001	Downregulation of microRNA-100 enhances the ICMT-Rac1 signaling and promotes metastasis of hepatocellular carcinoma cells.
genetics_knock down_promote	hsa-mir-101	"Carcinoma, Esophageal"	25400732	decreased expression of miR-101 might promote metastasis of human ESCC by inducing accumulation of EZH2 protein.
genetics_knock down_promote	hsa-mir-101	Lung Neoplasms	25428391	"particle can induce the secretion of interleukin-1¦Â. Interleukin-1¦Â subsequently induces the downregulation of mir-101, which may result in the upregulated level of EZH2, and occurrence of lung cancer. We for the first time proposed the role interleukin-1¦Â-mir-101-EZH2 axes in the particle-induced lung cancer. Further study may be needed to decipher the detailed mechanism involved."
genetics_knock down_promote	hsa-mir-34a	Prostate Neoplasms	25436980	"the bone metastasis and anti-apoptotic effects found in Ras signaling-activated prostate cancer cells require miR-34a deficiency, which in turn aids in cell survival by activating the WNT and anti-apoptotic signaling pathways thereby inducing TCF7 and BIRC5 expressions."
genetics_knock down_promote	hsa-mir-34a	Diabetes Mellitus	25483877	"Knockdown of miR-34a slightly decreased proliferation, but as apoptosis and NO synthesis were highly reduced, miR-34a may be further investigated as a therapeutic target to reduce β-cell death and dysfunction."
genetics_knock down_promote	hsa-mir-7	Breast Neoplasms	25532106	Suppression of miR-7 in the MCF-7 cell line resulted in enhanced colony formation activity but not cell migration
genetics_knock down_promote	hsa-mir-204	Prostate Neoplasms	25630658	"not only tumor suppressor micro-RNA loss, but also significant genome rearrangement-driven regulatory loop perturbations play a role in the advanced cancer progression, conferring better pro-survival and metastatic potential."
genetics_knock down_promote	hsa-mir-26a	Neoplasms [unspecific]	25668004	Loss of tumour-suppressive miR-26a/b enhanced cancer cell migration and invasion in OSCC through direct regulation of TMEM184B. Our data describing pathways regulated by tumour-suppressive miR-26a/b provide new insights into the potential mechanisms of OSCC oncogenesis and metastasis.
genetics_knock down_promote	hsa-mir-26b	Neoplasms [unspecific]	25668004	Loss of tumour-suppressive miR-26a/b enhanced cancer cell migration and invasion in OSCC through direct regulation of TMEM184B. Our data describing pathways regulated by tumour-suppressive miR-26a/b provide new insights into the potential mechanisms of OSCC oncogenesis and metastasis.
genetics_knock down_promote	hsa-mir-1	Prostate Neoplasms	25802280	Our data support the existence of an AR-miR-1-SRC regulatory network.We propose that loss of miR-1 is one mechanistic link between low canonical Androgen receptor (AR) output and SRC-promoted metastatic phenotypes.
genetics_knock down_promote	hsa-mir-23a	Idiopathic Pulmonary Hypertension	25815108	"Finally we found that silencing of miR23a resulted in an increase of the expression of PGC1¦Á, as well as in its well-known regulated genes CYC, SOD, NRF2,and HO1. The results point to the utility of circulating miRNA expression as a biomarker of disease progression."
genetics_knock down_promote	hsa-mir-146b	"Carcinoma, Thyroid, Papillary"	25819770	"The results showed that PTC cells overexpress miR-146b and miR-222 in exosomes; and that factors released by both normal thyroid and PTC cells alter proliferation of other cells in a complex manner. The intercellular interactions were likely conferred in part by exosomal miRNA, which can potentially be developed as biomarkers of PTC recurrence."
genetics_knock down_promote	hsa-mir-222	"Carcinoma, Thyroid, Papillary"	25819770	"The results showed that PTC cells overexpress miR-146b and miR-222 in exosomes; and that factors released by both normal thyroid and PTC cells alter proliferation of other cells in a complex manner. The intercellular interactions were likely conferred in part by exosomal miRNA, which can potentially be developed as biomarkers of PTC recurrence."
genetics_knock down_promote	hsa-mir-150	Heart Failure	25824147	we show that genetic deletion of miR-150 in mice causes abnormalities in cardiac structural and functional remodelling after MI.
genetics_knock down_promote	hsa-mir-150	Myocardial Infarction	25824147	we show that genetic deletion of miR-150 in mice causes abnormalities in cardiac structural and functional remodelling after MI.
genetics_knock down_promote	hsa-mir-155	"Lymphoma, B-Cell"	25829072	"A deficiency of miR-155 in the immune system causes attenuated immune functions. Clinically, several types of malignancy including diffuse large B-cell lymphoma have high miR-155 expression levels."
genetics_knock down_promote	hsa-mir-21	Acute Kidney Failure	25844699	"Knockdown of miR-21 upregulated its target effectors programmed cell death protein 4 and phosphatase and tensin homolog deleted on chromosome 10 expression, resulted in an increase in apoptosis, and exacerbated lipopolysaccharide-induced acute kidney injury."
genetics_knock down_promote	hsa-mir-155	Mycobacterium tuberculosis Infection	25846955	"Following infection, miR-155-deficient C57BL/6 mice died significantly earlier and had significantly higher numbers of CFU in lungs than wild-type mice."
genetics_knock down_promote	hsa-mir-377	Lymphoma	25889255	Our results suggest that miR-377 is an important negative regulator of E2F and MAP3K7/NF-kB signaling pathway in melanoma cells; it is tempting to speculate that its silencing in melanoma promotes the tumorigenic and metastatic potential of the cells through activation of these pathways.
genetics_knock down_promote	hsa-mir-142	Primary Immunodeficiency Disease	25931583	"miR-142 as an essential regulator of lymphopoiesis, and suggest that lesions in this miRNA gene may lead to primary immunodeficiency."
genetics_knock down_promote	hsa-mir-132	Inflammation	26052826	Blockage of miR-132 using miR-132 inhibitor reversed the Ach action upon LPS-induced release of inflammatory mediators and reduction in AchE protein/activity.
genetics_knock down_promote	hsa-mir-205	Prostate Neoplasms	26059417	Loss of tumor-suppressive microRNA-205 seems to enhance cancer cell migration and invasion in prostate cancer through direct regulation of centromere protein F. Our data describing pathways regulated by tumor-suppressive microRNA-205 provide new insights into the potential mechanisms of prostate cancer oncogenesis and metastasis.
genetics_knock down_promote	hsa-mir-133a	Heart Failure	26064437	attenuation of miR-133a contributes to the exacerbation of diabetes mediated cardiac autophagy and hypertrophy in heart failure
genetics_knock down_promote	hsa-mir-133a	Hypertrophy	26064437	attenuation of miR-133a contributes to the exacerbation of diabetes mediated cardiac autophagy and hypertrophy in heart failure
genetics_knock down_promote	hsa-mir-21	"Carcinoma, Hepatocellular"	26282675	"microRNA-21 knockdown led to increased HBP1 and p53 and subsequently reduced lipogenesis and delayed G1/S transition, and the additional treatment of HBP1-siRNA antagonised the effect of microRNA-21-ASO, suggesting that HBP1 mediated the inhibitory effects of microRNA-21-ASO on both hepatic lipid accumulation and hepatocarcinogenesis."
genetics_knock down_promote	hsa-mir-622	Colorectal Carcinoma	26333174	miR-622 inhibited tumor proliferation and migration in vitro.
genetics_knock down_promote	hsa-mir-214	Parkinson Disease	26349993	"The loss of miR-214 in PD resulted in the increase of ¦Á-synuclein expression, which was the potential mechanism underlying the neuroprotective effects of Resveratrol."
genetics_knock down_promote	hsa-mir-195	Cervical Neoplasms	26511972	reducing the endogenous miR-195 level by miR-195 inhibitor promoted the proliferation of cervical cancer cells.
genetics_knock down_promote	hsa-mir-377	Ischemia-Reperfusion Injury	26564600	"These findings indicate that HF increased miR-377 expression in the myocardium, which is detrimental to stem cell function, and transplantation of miR-377 knockdown hCD34(+) cells into ischemic myocardium promoted their angiogenic ability, attenuating left ventricular remodeling and cardiac fibrosis."
genetics_knock down_promote	hsa-mir-150	Sepsis	26743170	miR-150(-/-) mice died rapidly after sepsis.
genetics_knock down_promote	hsa-mir-29b	"Carcinoma, Renal Cell"	26823729	"Inhibition of miR-29b expression could promote apoptosis, and inhibit proliferation and invasion ability in SN12-PM6 cells."
genetics_knock down_promote	hsa-mir-150	Obesity	26833392	miR-150KO mice displayed exacerbated obesity-associated tissue inflammation and systemic insulin resistance
genetics_knock down_promote	hsa-mir-29c	"Carcinoma, Embryonal"	26848028	"Inhibition of miR�9c promoted proliferation, and suppressed the apoptosis and differentiation of P19 cells."
genetics_knock down_promote	hsa-mir-196a	Renal Fibrosis	26940097	depletion of renal miR-196a/b by miR-196a/b antagomirs substantially aggravated UUO-induced renal fibrosis.
genetics_knock down_promote	hsa-mir-196b	Renal Fibrosis	26940097	depletion of renal miR-196a/b by miR-196a/b antagomirs substantially aggravated UUO-induced renal fibrosis.
genetics_knock down_promote	hsa-mir-126a	Sepsis	26968021	"The down-regulation of miR-126a-3p in endothelial cells resulted in the increased apoptosis, and decreased proliferation and migration,"
genetics_knock down_promote	hsa-mir-124	Glioblastoma	26993295	inhibitor of miR-124 promoted the expression of STAT3 and cell proliferation.
genetics_knock down_promote	hsa-mir-181	Autism Spectrum Disorder	27017280	this loss-of miR-181c function resulted in enhanced neurite sprouting and reduced synaptogenesis
genetics_knock down_promote	hsa-mir-4282	Colorectal Carcinoma	27120047	"It was found that miR-4282 inhibition promoted cell growth, migration and invasion (P<0.05) of HT29 and HCT116 colorectal carcinoma cells while miR-4282 overexpression suppressed cell growth and mobility (P<0.05)."
genetics_knock down_promote	hsa-mir-146a	Ischemia-Reperfusion Injury	27250735	miR146a exerts a kidney protective effect through negative regulation of acute inflammatory response
genetics_knock down_promote	hsa-mir-505	"Carcinoma, Hepatocellular"	27259809	"the up-regulation of miR-505 suppressed, whereas the down-regulation of miR-505 promoted proliferation, invasion and epithelial-mesenchymal transition in MHCC97."
genetics_knock down_promote	hsa-mir-206	Rhabdomyosarcoma	27277678	Genetic deletion of miR-206 in a mouse model of FN-RMS accelerated and exacerbated tumor development
genetics_knock down_promote	hsa-mir-150	Diabetic Retinopathy	27304911	deletion of miR-150 significantly increased the retinal pathological angiogenesis
genetics_knock down_promote	hsa-mir-34a	Obesity	27377585	miR-34a(-/-) mice are susceptible to diet-induced obesity.
genetics_knock down_promote	hsa-mir-122	Pterygium	27415790	"Decreased expression of miR-122 in pterygium might result in abnormal cell apoptosis via its regulation of the expression of Bcl-w, and subsequently contribute to the development of pterygium."
genetics_knock down_promote	hsa-mir-146a	Ischemia-Reperfusion Injury	27444565	"After unilateral IRI, miR-146a-/- mice exhibited more extensive tubular injury, inflammatory infiltrates, and fibrosis than wild-type mice."
genetics_knock down_promote	hsa-mir-145	Prostate Neoplasms	27465939	"ASC-derived conditioned medium (CM) significantly inhibited PC3M-luc2 cell proliferation, inducing apoptosis, but the effect was canceled by miR-145 knockdown in ASCs."
genetics_knock down_promote	hsa-mir-200b	"Squamous Cell Carcinoma, Esophageal"	27496804	"Correlating with the frequent loss of miR-200b in ESCC, both CDK2 and PAF levels are significantly increased in ESCC tumors compared to case-matched normal tissues."
genetics_knock down_promote	hsa-mir-27a	Rheumatoid Arthritis	27498552	"However, miR-27a inhibition promoted the migration and invasion of FLS."
genetics_knock down_promote	hsa-mir-424	"Carcinoma, Lung, Non-Small-Cell"	27500472	It was found that down-regulation of miR-424-3p was pronouncedly associated with NSCLC progression and overall prognosis;
genetics_knock down_promote	hsa-let-7	Kaposi Sarcoma	27531260	"Let-7 silencing may activate the replication of KSHV, possibly through up-regulating MAP4K4 and its downstream molecules COX-2, MMP-13, and phosphorylation of ERK1/2, finally results in the progression of Kaposi sarcoma."
genetics_knock down_promote	hsa-mir-15a	Leukemia	27533467	both miR-15a deficient HSC and B1P cells are capable of repopulating irradiated recipients and produce higher numbers of B1 cells than sources with normal miR-15a/16 levels.
genetics_knock down_promote	hsa-mir-142	"Carcinoma, Hepatocellular"	28177895	Over-expression of Thrombospondin 4 correlates with loss of miR-142 and contributes to migration and vascular invasion of advanced hepatocellular carcinoma.
genetics_knock down_promote	hsa-mir-7	Hypogonadotropic Hypogonadism	28218624	Loss of microRNA-7a2 induces hypogonadotropic hypogonadism and infertility.
genetics_knock down_promote	hsa-mir-320a	"Carcinoma, Hepatocellular"	28288874	Loss of exosomal miR-320a from cancer-associated fibroblasts contributes to HCC proliferation and metastasis.
genetics_knock down_promote	hsa-mir-423	Glioma	28381178	miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway.
genetics_knock down_promote	hsa-mir-126	"Carcinoma, Hepatocellular"	28639884	Loss of tumor suppressor miR-126 contributes to the development of hepatitis B virus-related hepatocellular carcinoma metastasis through the upregulation of ADAM9.
genetics_knock down_promote	hsa-mir-200a	"Squamous Cell Carcinoma, Oral"	29480379	lack of significant alterations in miR-31 and miR-200a levels in saliva of OLP patients may be indicative for absence of malignant transformation
genetics_knock down_promote	hsa-mir-31	"Squamous Cell Carcinoma, Oral"	29480379	lack of significant alterations in miR-31 and miR-200a levels in saliva of OLP patients may be indicative for absence of malignant transformation
genetics_knock down_promote	hsa-mir-146a	Gout	29544526	"miR-146a provides negative feedback regulation of gouty arthritis development and lack of miR-146a enhances gouty arthritis via upregulation of TRAK6, IRAK-1, and the NALP3 inflammasome function"
genetics_knock down_promote	hsa-mir-15a	"Carcinoma, Lung, Non-Small-Cell"	29551936	Knocking down MiR-15a expression promotes the occurrence and development and induces the EMT of NSCLC cells in vitro
genetics_knock down_promote	hsa-mir-125b	"Leukemia, B-Cell"	29555645	physiological silencing of miR-125b is required for normal B-cell development and also acts as a mechanism of cancer suppression
genetics_knock down_promote	hsa-mir-21	Spinal Cord Injuries	29934690	Knockdown of MicroRNA-21 Promotes Neurological Recovery After Acute Spinal Cord Injury.
genetics_knock down_promote	hsa-mir-148b	Endometrial Neoplasms	30146796	Loss of exosomal miR-148b from cancer-associated fibroblasts promotes endometrial cancer cell invasion and cancer metastasis.
genetics_knock down_promote	hsa-mir-146b	"Leukemia, Lymphoblastic, Acute, T-Cell"	30362152	Loss of miR-146b-5p promotes T cell acute lymphoblastic leukemia migration and invasion via the IL-17A pathway.
genetics_knock down_suppress	hsa-mir-223	"Leukemia, Promyelocytic, Acute"	16325577	"In line with this, both RNAi against NFI-A and ectopic expression of miR-223 in acute promyelocytic leukemia (APL) cells enhance differentiation, whereas miR-223 knockdown inhibits the differentiation response to RA."
genetics_knock down_suppress	hsa-mir-1-2	Chronic Heart Failure	17397913	deletion
genetics_knock down_suppress	hsa-mir-24-1	Tourette Syndrome	17462786	"A mutation in the 3'UTR of the SLITRK1 gene which is associated with Tourette's syndrome was found to enhance repression of the SLITRK mRNA by miR-189, presumably preventing SLITRK1's promotion of dendritic growth."
genetics_knock down_suppress	hsa-let-7a-1	Colon Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7a-1	Lung Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7a-2	Colon Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7a-2	Lung Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7a-3	Colon Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7a-3	Lung Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7b	Colon Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7b	Lung Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7c	Colon Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7c	Lung Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7d	Colon Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7d	Lung Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7e	Colon Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7e	Lung Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7f-1	Colon Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7f-1	Lung Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7f-2	Colon Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7f-2	Lung Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7g	Colon Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7g	Lung Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7i	Colon Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-let-7i	Lung Neoplasms	17965831	"Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers."
genetics_knock down_suppress	hsa-mir-221	Carotid Artery Diseases	19150885	miR-221: knockdown of miR-221 and miR-222 in rat carotid arteries suppressed VSMC proliferation in vivo and neointimal lesion formation after angioplasty. The results indicate that miR-221 and miR-222 are novel regulators for VSMC proliferation and neointimal hype
genetics_knock down_suppress	hsa-mir-222	Carotid Artery Diseases	19150885	miR-222: knockdown of miR-221 and miR-222 in rat carotid arteries suppressed VSMC proliferation in vivo and neointimal lesion formation after angioplasty. The results indicate that miR-221 and miR-222 are novel regulators for VSMC proliferation and neointimal hype
genetics_knock down_suppress	hsa-mir-10b	Myocardial Infarction	19595696	Knockdown of microRNA-181 by lentivirus decreases the arrhythmogenic effect of skeletal myoblast transplantation in rat with myocardial infarction.
genetics_knock down_suppress	hsa-mir-150	"Carcinoma, Hepatocellular"	19617899	repressed in a subset of primary tumorscharacterized by poor prognosis; loss of miR-122 expression correlates with suppression of the hepatic phenotype and gain of metastatic properties; a diagnostic and prognostic marker
genetics_knock down_suppress	hsa-mir-15a	"Leukemia, Lymphocytic, Chronic, B-Cell"	19744129	"Their aberrant expression has been associated with solid tumors and hematopoietic malignancies as suggested by the frequent deletion of mir-15a and mir-16-1 in chronic lymphocytic leukemia, the increased levels of mir-155 in diffuse large B-cell lymphomas and the increased levels of mir-181 in acute myeloid leukemia M1 and M2. "
genetics_knock down_suppress	hsa-mir-16-1	"Leukemia, Lymphocytic, Chronic, B-Cell"	19744129	"Their aberrant expression has been associated with solid tumors and hematopoietic malignancies as suggested by the frequent deletion of mir-15a and mir-16-1 in chronic lymphocytic leukemia, the increased levels of mir-155 in diffuse large B-cell lymphomas and the increased levels of mir-181 in acute myeloid leukemia M1 and M2. "
genetics_knock down_suppress	hsa-mir-126	Asthma	19843690	Selective blockade of microRNA (miR)-126 suppressed the asthmatic phenotype
genetics_knock down_suppress	hsa-mir-15a	"Leukemia, Lymphocytic, Chronic, B-Cell"	20129242	miR-15a and miR-16-1 were the first microRNAs linked to cancer because their genes are commonly deleted in human chronic lymphocytic leukemia (CLL)
genetics_knock down_suppress	hsa-let-7a-1	Neoplasms [unspecific]	20614490	let-7a:Gastric carcinoma has relatively lower expression of let-7a
genetics_knock down_suppress	hsa-let-7a-2	Neoplasms [unspecific]	20614490	let-7a:Gastric carcinoma has relatively lower expression of let-7a
genetics_knock down_suppress	hsa-let-7a-3	Neoplasms [unspecific]	20614490	let-7a:Gastric carcinoma has relatively lower expression of let-7a
genetics_knock down_suppress	hsa-mir-200a	Neoplasms [unspecific]	20832727	miR-200a:Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells
genetics_knock down_suppress	hsa-mir-200b	Neoplasms [unspecific]	20832727	miR-200b:Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells
genetics_knock down_suppress	hsa-mir-200c	Neoplasms [unspecific]	20832727	miR-200c:Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells
genetics_knock down_suppress	hsa-mir-21	Breast Neoplasms	21219636	"In vitro assays showed that ERBB2 is a direct target of miR-125a-5p, which potently suppressed the proliferation of gastric cancer cells"
genetics_knock down_suppress	hsa-mir-221	"Carcinoma, Hepatocellular"	22009537	miR-221 silencing blocks hepatocellular carcinoma and promotes survival.
genetics_knock down_suppress	hsa-mir-124-1	Neuroblastoma	22024478	"Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR."
genetics_knock down_suppress	hsa-mir-124-2	Neuroblastoma	22024478	"Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR."
genetics_knock down_suppress	hsa-mir-124-3	Neuroblastoma	22024478	"Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR."
genetics_knock down_suppress	hsa-mir-183	"Carcinoma, Thyroid, Medullary"	22024754	MiR-183 knockdown in an MTC cell line (TT cells) reduced cellular proliferation in association with elevated LC3B expression.
genetics_knock down_suppress	hsa-mir-143	Neoplasms [unspecific]	22330136	Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.
genetics_knock down_suppress	hsa-mir-145	Neoplasms [unspecific]	22330136	Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.
genetics_knock down_suppress	hsa-mir-122	Hepatitis C Virus Infection	22898980	The use of an HSP90 inhibitor or knockdown of HSP90 decreased GW182 and miR-122 expression and significantly reduced HCV replication.
genetics_knock down_suppress	hsa-mir-181b-1	"Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic"	22916024	Deletion of mir-181a-1/b-1 expression inhibits the development of Notch1 oncogene-induced T cell acute lymphoblastic leukemia (T-ALL). mir-181a-1/b-1 controls the strength and threshold of Notch activity in tumorigenesis in part by dampening multiple negative feedback regulators downstream of NOTCH and pre-T cell receptor (TCR) signaling pathways.
genetics_knock down_suppress	hsa-mir-21	Heart Failure	22923342	"Atrial miR-21 knockdown suppresses atrial fibrosis and AF promotion, implicating miR-21 as an important signaling molecule for the AF substrate and pointing to miR-21 as a potential target for molecular interventions designed to prevent AF"
genetics_knock down_suppress	hsa-let-7i	"Carcinoma, Renal Cell"	22926558	"We also validated the prognostic value of miRNA let-7i in RCC. miR-138, located in chromosome 3p deletion, was also found to have suppressive effects on tumor proliferation and migration abilities."
genetics_knock down_suppress	hsa-mir-138-1	"Carcinoma, Renal Cell"	22926558	"We also validated the prognostic value of miRNA let-7i in RCC. miR-138, located in chromosome 3p deletion, was also found to have suppressive effects on tumor proliferation and migration abilities."
genetics_knock down_suppress	hsa-mir-138-2	"Carcinoma, Renal Cell"	22926558	"We also validated the prognostic value of miRNA let-7i in RCC. miR-138, located in chromosome 3p deletion, was also found to have suppressive effects on tumor proliferation and migration abilities."
genetics_knock down_suppress	hsa-mir-21	Glioma	23077620	Silencing of microRNA-21 confers radio-sensitivity through inhibition of the PI3K/AKT pathway and enhancing autophagy in malignant glioma cell lines
genetics_knock down_suppress	hsa-mir-150	Leukemia	23079661	Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia
genetics_knock down_suppress	hsa-mir-204	Neoplasms [unspecific]	23285024	Genomic Loss of Tumor Suppressor miRNA-204 Promotes Cancer Cell Migration and Invasion by Activating AKT/mTOR/Rac1 Signaling and Actin Reorganization
genetics_knock down_suppress	hsa-mir-21	Ischemia-Reperfusion Injury	23681145	"Knockdown of miR-21 induced significant up-regulation of programmed cell death protein 4 and phosphatase and tensin homolog deleted on chromosome 10, two proapoptotic target effectors of miR-21, and resulted in significant down-regulation of phosphorylated protein kinase B and increased tubular cell apoptosis."
genetics_knock down_suppress	hsa-mir-21	Glioblastoma	23732394	Silencing of miR-21 by locked nucleic acid-lipid nanocapsule complexes sensitize human glioblastoma cells to radiation-induced cell death.
genetics_knock down_suppress	hsa-mir-18a	Immune System Disease [unspecific]	24131405	Treatment of cells with a microRNA-18a mimic in PCPS (PCPS/miR-18) knocked down 90% expression of the microRNA-18a target gene ATM.
genetics_knock down_suppress	hsa-mir-17	Medulloblastoma	24145352	Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression.
genetics_knock down_suppress	hsa-mir-19a	Medulloblastoma	24145352	Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression.
genetics_knock down_suppress	hsa-mir-23a	"Squamous Cell Carcinoma, Head and Neck"	24317043	Transfection with anti-miR-23a inhibited the proliferation of HN4 cells and induced cell apoptosis.
genetics_knock down_suppress	hsa-mir-196b	"Leukemia, Myeloid, Acute"	24334453	"Therapeutic inhibition of microRNA-21 and microRNA-196b inhibited in vitro leukemic colony forming activity and depleted in vivo leukemia-initiating cell activity of HOX-based leukemias, which led to leukemia-free survival in a murine AML model and delayed disease onset in xenograft models."
genetics_knock down_suppress	hsa-mir-21	"Leukemia, Myeloid, Acute"	24334453	"Therapeutic inhibition of microRNA-21 and microRNA-196b inhibited in vitro leukemic colony forming activity and depleted in vivo leukemia-initiating cell activity of HOX-based leukemias, which led to leukemia-free survival in a murine AML model and delayed disease onset in xenograft models."
genetics_knock down_suppress	hsa-mir-92a	"Leukemia, Promyelocytic, Acute"	24385779	Down-regulation of miR-92a in APL cell line (HL-60) by LNA antagomir extensively decreased cell viability in APL.
genetics_knock down_suppress	hsa-let-7b	Neoplasms [unspecific]	24423609	Reduction of let-7a3/let-7b miRNA may be one of mechanisms leading to overexpression of HMGA2 in AT/RT tissues.
genetics_knock down_suppress	hsa-mir-21	Heart Failure	24551276	"After injection of miR-21 antagonist, the the cardiac atrophy and cardiac fibrosis were conspicuously ameliorated."
genetics_knock down_suppress	hsa-mir-92a	"Leukemia, Promyelocytic, Acute"	24627869	The assessment of the apoptosis and necrosis indicates that miR-92a inhibition can decrease the viable HL-60 cells and this is at least partially due to induction of apoptosis.
genetics_knock down_suppress	hsa-mir-17	Multiple Sclerosis	24644282	T cell-specific miR-17-92 deficiency reduced TH17 differentiation and ameliorated experimental autoimmune encephalomyelitis (EAE) symptoms.
genetics_knock down_suppress	hsa-mir-155	Encephalomyelitis	24648472	MiR-155 (-/-) mice are highly resistant to experimental autoimmune encephalomyelitis (EAE)
genetics_knock down_suppress	hsa-mir-18a	Prostate Neoplasms	24752237	"Interestingly, miR-18a knockdown decreased cell growth in prostate cancer cells and significantly decreased prostate tumor growth in in vivo nude mice experiments through STK4-mediated dephosphorylation of AKT and thereby inducing apoptosis."
genetics_knock down_suppress	hsa-mir-21	"Carcinoma, Lung, Non-Small-Cell"	24804226	Silencing miR-21 sensitizes non-small cell lung cancer A549 cells to ionizing radiation through inhibition of PI3K/Akt.
genetics_knock down_suppress	hsa-mir-182	Ovarian Neoplasms	24825857	"we found that anti-miR182 treatment can significantly reduce tumor burden (size), local invasion, and distant metastasis compared with its control in both models."
genetics_knock down_suppress	hsa-mir-17	Medulloblastoma	24928431	"Remarkably, deletion of the miR-17�2 cluster abolished the development of SHH-MB in Ptch1(+/-) mice."
genetics_knock down_suppress	hsa-mir-92a	Myocardial Ischemic-Reperfusion Injury	24941323	Inhibiting miR-92a can attenuate myocardiocyte apoptosis induced by hypoxia/reoxygenation by targeting Smad7.
genetics_knock down_suppress	hsa-mir-221	"Carcinoma, Hepatocellular"	24993451	Bioinformatics analysis identifies miR-221 as a core regulator in hepatocellular carcinoma and its silencing suppresses tumor properties.
genetics_knock down_suppress	hsa-mir-145	Atherosclerosis	25008143	Absence of miR-143/145 significantly reduced atherosclerotic plaque size and macrophage infiltration.
genetics_knock down_suppress	hsa-mir-21	Lung Neoplasms	25065740	"PHF8 promotes miR-21 expression in human lung cancer, and miR-21 knockdown blocks the effects of PHF8 on proliferation and apoptosis of lung cancer cells."
genetics_knock down_suppress	hsa-mir-21	Obesity	25141837	"MiR-21 inhibition reduced body weight, as well as adipocyte size and serum triglycerides were significantly decreased."
genetics_knock down_suppress	hsa-mir-17	"Leukemia, Lymphocytic, Chronic, B-Cell"	25339346	In-vitro administration of antagomiR17 effectively reduced miR-17 expression and the proliferation of CLL-like MEC-1 cells.
genetics_knock down_suppress	hsa-mir-21	Vascular Disease [unspecific]	25360215	"Low expression of miR-21 significantly inhibited VSMC proliferation, invasion and migration."
genetics_knock down_suppress	hsa-mir-21	"Leukemia, Lymphoblastic, Acute"	25451263	"Transient inhibition of miR-21 resulted in increased apoptosis, PTEN upregulation and AKT dephosphorylation, whereas ectopic overexpression of miR-21 further conferred imatinib resistance."
genetics_knock down_suppress	hsa-mir-19b	"Carcinoma, Embryonal"	25483911	The results demonstrated that miR-19b knockdown inhibited the proliferation and apoptosis of P19 cells.
genetics_knock down_suppress	hsa-let-7c	Heart Failure	25505600	"Let-7c inhibitor prevented the deterioration of cardiac function postinfarction, as demonstrated by preserved LV ejection fraction and elevated cardiac output."
genetics_knock down_suppress	hsa-mir-155	Neoplasms [unspecific]	25598954	the proper increase of miR-155 inhibitor concentration can inhibit miR-155 and consequently increase caspase-3 activity and induce apoptosis in the Jurkat cells leading to cell death ultimately.
genetics_knock down_suppress	hsa-mir-17	"Leukemia, Myeloid, Chronic"	25647305	"Furthermore, overexpression of c-Myc or miR-17/20a alleviated NC induced differentiation and apoptosis in K562 cells."
genetics_knock down_suppress	hsa-mir-20a	"Leukemia, Myeloid, Chronic"	25647305	"Furthermore, overexpression of c-Myc or miR-17/20a alleviated NC induced differentiation and apoptosis in K562 cells."
genetics_knock down_suppress	hsa-mir-155	Spinal Cord Injuries	25651871	Mir-155 deficiency suppresses Th17 cell differentiation and improves locomotor recovery after SCI.
genetics_knock down_suppress	hsa-let-7b	Neoplasms [unspecific]	25682900	"our findings suggest that let-7b contributes to the fidelity of cell division via regulation of Aurora B. Moreover, the loss of let-7b in aggressive tumors may drive tumorigenesis by up-regulation of Aurora B and other targets of the miRNA, which further supports the role of let-7b in tumor suppression."
genetics_knock down_suppress	hsa-mir-21	Cholangiocarcinoma	25769721	anti-miR-21 treatment reduced liver tumor growth and prevented tumor development.
genetics_knock down_suppress	hsa-mir-122	Hepatitis C Virus Infection	25848473	"miR-122 promotes HCV accumulation, inhibition of miR-122 has been shown as an effective therapy for the treatment of HCV infection in both chimpanzees and humans."
genetics_knock down_suppress	hsa-mir-221	Rheumatoid Arthritis	25891943	Downregulation of miR-221 significantly suppressed the expression of pro-inflammatory cytokines and the chemokine
genetics_knock down_suppress	hsa-mir-31	Myocardial Infarction	25925791	miR-31 downregulation alleviated myocardial infarct size in vivo.
genetics_knock down_suppress	hsa-mir-208a	Myocardial Infarction	25936493	Overexpression of antagomir-208a and pretreatment with atorvastatin and valsartan in the AMI group significantly decreased the area of myocardial fibrosis induced by infarction.
genetics_knock down_suppress	hsa-mir-21	Glioblastoma	25991676	Both MPS1 and miR-21 depletion suppressed GBM cell proliferation
genetics_knock down_suppress	hsa-mir-195	Diabetic Cardiomyopathies	25994075	Therapeutic silencing of miR-195 reduces myocardial hypertrophy and improves coronary blood flow and myocardial function in diabetes
genetics_knock down_suppress	hsa-mir-21	Colorectal Carcinoma	25994220	"miR-21-knockout mice showed reduced expression of proinflammatory and procarcinogenic cytokines (interleukin (IL) 6, IL-23, IL-17A and IL-21) and a decrease in the size and number of tumours compared with the control mouse group."
genetics_knock down_suppress	hsa-let-7	Neoplasms [unspecific]	26033159	"we found that expression of DICER1 hotspot mutants promoted cell proliferation, whereas wild-type (WT) DICER1 inhibited cell proliferation. Furthermore, targets of let-7 family miRNAs are enriched among the up-regulated genes, suggesting that loss of let-7 may be impacting downstream pathways. Our results reveal that DICER1 hotspot mutations are implicated in common malignancies and may constitute a unique oncogenic pathway."
genetics_knock down_suppress	hsa-mir-34a	Myocardial Infarction	26082557	locked nucleic acid-based anti-miR-34a treatment diminished post-MI miR-34a upregulation in adult hearts and significantly improved post-MI remodeling.
genetics_knock down_suppress	hsa-mir-150	Myocardial Infarction	26109086	MicroRNA-150 deletion in mice protects kidney from myocardial infarction-induced acute kidney injury.
genetics_knock down_suppress	hsa-mir-214	Liver Fibrosis	26122702	Pdgf-c Tg mice treated with LNA-antimiR-214 showed a marked reduction in fibrosis and tumor incidence compared with saline or LNA-miR-control-injected control mice.
genetics_knock down_suppress	hsa-mir-17	Graft-Versus-Host Disease	26138686	"Furthermore, we evaluated a translational approach and found that systemic administration of antagomir to block miR-17 or miR-19b in this cluster significantly inhibited alloreactive T-cell expansion and interferon-γ (IFNγ) production, and prolonged"
genetics_knock down_suppress	hsa-mir-19b	Graft-Versus-Host Disease	26138686	systemic administration of antagomir to block miR-17 or miR-19b in this cluster significantly inhibited alloreactive T-cell expansion and interferon-γ (IFNγ) production
genetics_knock down_suppress	hsa-mir-372	"Adenocarcinoma, Gastric"	26151747	"Subcutaneously delivered LNAs reduce tumor growth of AGS xenografts in mice, upon formation of a stable, specific heteroduplex with the targeted miR-372 and -373 and LATS2 upregulation."
genetics_knock down_suppress	hsa-mir-150	Liver Injury	26196694	miR-150 deficiency prevents Fas-induced hepatocyte apoptosis and liver injury through regulation of the Akt pathway.
genetics_knock down_suppress	hsa-mir-181a	Ischemic Diseases [unspecific]	26283227	"Delivery of anti-miR-181a, which neutralizes endogenous miR-181a, significantly attenuated H2O2-induced decrease of HKII expression and disruption of mitochondrial membrane potential, improving the survival of MSCs exposed to H2O2."
genetics_knock down_suppress	hsa-mir-31	"Squamous Cell Carcinoma, Esophageal"	26286729	anti-miR-31 reduced miR-31 overexpression (P = .002) and suppressed the esophageal preneoplasia in Zn-deficient rats.
genetics_knock down_suppress	hsa-mir-214	"Adenocarcinoma, Lung"	26299367	"downregulation of miR-214 expression in CSLCs resulted in a significant decrease in spheroid formation and the expression of the stem-cell markers Nanog, Oct-4, and Sox-2."
genetics_knock down_suppress	hsa-mir-21	"Fatty Liver, Non-Alcoholic"	26338827	"MicroRNA-21 inhibition or suppression decreases liver injury, inflammation and fibrosis"
genetics_knock down_suppress	hsa-mir-155	Stroke	26354913	In Vivo Inhibition of miR-155 Promotes Recovery after Experimental Mouse Stroke.
genetics_knock down_suppress	hsa-mir-20a	"Carcinoma, Lung, Non-Small-Cell"	26356817	Stable knock down of miR-20a increases TβRII expression and inhibits tumorigenicity of lung cancer cells in vivo.
genetics_knock down_suppress	hsa-mir-205	Neoplasms [unspecific]	26446417	"When HEC-50B cells and HEC-1-A cells were treated with anti-miR-205 inhibitor, the migration and invasion were decreased as compared with the negative control."
genetics_knock down_suppress	hsa-mir-222	Pancreatic Neoplasms	26535064	"we co-transfected miR-222 inhibitor and p57 si-RNA into Capan-2 cells, and found that proliferation-suppressing effects of miR-222 inhibitor on Capan-2 cells could be partially reversed by silencing p57."
genetics_knock down_suppress	hsa-mir-192	"Adenocarcinoma, Lung"	26550150	MiR-192 inhibitor treated tumor exhibits sensitivity to cisplatin and gemcitabine therapy.
genetics_knock down_suppress	hsa-mir-503	"Carcinoma, Esophageal"	26580839	The specific inhibition of miR-503 expression remarkably suppressed proliferation and invasion of tumor cells.
genetics_knock down_suppress	hsa-mir-96	Bladder Neoplasms	26582573	the inhibition of miR-96 expression remarkably decreased cell proliferation and promoted cell apoptosis of BC cell lines
genetics_knock down_suppress	hsa-mir-155	Acute Myocardial Infarction	26589288	"We reveal that in vivo, miR-155 knockout improves left ventricular function, reduces infarct size, and attenuates collagen deposition, whereas overexpression of miR-155 produces the opposite effects."
genetics_knock down_suppress	hsa-mir-106b	"Carcinoma, Renal Cell"	26648244	Downregulation of miR-106b with a synthesized inhibitor suppressed cell migration and proliferation and induced renal cancer cell apoptosis
genetics_knock down_suppress	hsa-mir-208a	Myocardial Infarction	26688617	"Therapeutic inhibition of miR-208a decreased cardiac fibrosis, hypertrophy, and apoptosis and significantly improved cardiac function 28 days after MI."
genetics_knock down_suppress	hsa-mir-210	Nervous System Diseases [unspecific]	26708520	"Application of miR-210 inhibitor efficiently downregulated endogenous miR-210, protected apoptosis and neurite retraction in bupivacaine damaged DRG neurons."
genetics_knock down_suppress	hsa-mir-184	"Adenocarcinoma, Pancreatic Ductal"	26722418	"The transfection of inhibitor effectively suppressed the expression of miR-184, and further inhibited both cell proliferation and invasion abilities, in addition to the up-regulation of pro-apoptotic protein caspase 3 expression."
genetics_knock down_suppress	hsa-mir-630	Ovarian Neoplasms	26725326	Treatment with the combination of anti-miR-630 and anti-vascular endothelial growth factor antibody in mice resulted in rescue of Dicer expression and significantly decreased tumor growth and metastasis.
genetics_knock down_suppress	hsa-mir-15b	Colorectal Carcinoma	26743779	"Inhibition of miR-15b activity by adenovirus carrying antimiR-15b sequence significantly increased MTSS1 and Klotho protein expression and subsequently decreased colony formation ability, invasion, and migration of HCT116 cells in vitro and liver metastasis of HCT116 tumors in vivo."
genetics_knock down_suppress	hsa-mir-193	Gastric Neoplasms	26753960	"In AGS and MKN-45 cells, miR-193-3p downregulation reduced cancer proliferation, migration and 5-FU chemoresistance in vitro, and tumorigenicity in vivo."
genetics_knock down_suppress	hsa-mir-126	Myocardial Infarction	26782549	miR-126 is down-regulated in myocardial ischemia-reperfusion injury and that the inhibition of miR-126 may protect against myocardial cell apoptosis caused by ischemia-reperfusion.
genetics_knock down_suppress	hsa-mir-223	Encephalomyelitis	26783338	We demonstrate that miR-223-knockout mice display significantly reduced active and adoptive-transfer experimental autoimmune encephalomyelitis
genetics_knock down_suppress	hsa-mir-125b	Amyotrophic Lateral Sclerosis	26794445	"by restoring A20 levels, miR-125b inhibition then sustains motor neuron survival."
genetics_knock down_suppress	hsa-mir-210	Myocardial Infarction	26807177	Inhibition of miR-210 expression improved the survival and cardiac function of MI mice.
genetics_knock down_suppress	hsa-mir-130b	"Carcinoma, Hepatocellular"	26861561	knockdown or overexpression of miR-130b inhibited and promoted proliferation and metastasis of HCC cells
genetics_knock down_suppress	hsa-mir-21	Myocardial Ischemic-Reperfusion Injury	26862785	recombinant HMGB1-box treatment protects against I/R injury and the mechanisms may involve inhibition of miR-21 expression.
genetics_knock down_suppress	hsa-mir-183	Pancreatic Adenocarcinoma	26870180	miR-183 knockdown decreased cell growth and motility in pancreatic cancer cells and significantly increased the expression of SOCS-6.
genetics_knock down_suppress	hsa-mir-146b	"Carcinoma, Thyroid, Papillary"	26883911	miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells
genetics_knock down_suppress	hsa-mir-222	Neoplasms [unspecific]	26909602	"Anti-miR-222 inhibitor treatment decreased cell proliferation, migration, tube formation, and induced apoptosis."
genetics_knock down_suppress	hsa-mir-199a	Pancreatic Neoplasms	26918939	"Inhibition of miR-199a/-214 using hairpin inhibitors significantly inhibited TGFβ-induced differentiation markers (e.g. α-SMA, collagen, PDGFβR), migration and proliferation."
genetics_knock down_suppress	hsa-mir-34a	Cholangiocarcinoma	26923637	"The inhibition of miR-34a decreased proliferation, migration and invasion in cholangiocarcinoma cells."
genetics_knock down_suppress	hsa-mir-125b	Melanoma	26968260	inhibition of miR-125b reduces migratory and invasive potentials without affecting cell proliferation in vitro.
genetics_knock down_suppress	hsa-mir-21	Ischemia-Reperfusion Injury	27030384	"With downregulation of miR-21, the protection of delayed IPC was attenuated and PHD2 protein was increased."
genetics_knock down_suppress	hsa-mir-223	Multiple Sclerosis	27083389	"miR223 promotes EAE, probably through enhancing DC activation and subsequently the differentiation of naive T cells toward Th1 and Th17 effector cells."
genetics_knock down_suppress	hsa-mir-25	Choriocarcinoma	27120728	Inhibition of miR-25 by its sponge in AGS cells resulted in suppressed cell viability (P<0.01) and promoted cell apoptosis (P<0.01)
genetics_knock down_suppress	hsa-mir-192	Liver Injury	27129188	"Functional experiments confirmed a protective effect of down-regulation of miR-192-5p in hepatocytes, suggesting a role of miR-192-5p in limiting liver injury."
genetics_knock down_suppress	hsa-mir-23b	"Carcinoma, Nasopharyngeal"	27150436	"inhibition of miR�3b could significantly suppress NPC cell proliferation, migration and invasion."
genetics_knock down_suppress	hsa-mir-128	Myocardial Ischemic-Reperfusion Injury	27150726	miR�28 antagomirs significantly reduced apoptosis in hearts subjected to I/R injury
genetics_knock down_suppress	hsa-mir-125b	"Leukemia, Myeloid, Chronic"	27158338	inhibition of miR-125b decreased the proliferation rates and promoted apoptosis with cell cycle arrest at the G0/G1 phase in both K562 and NB-4 cells
genetics_knock down_suppress	hsa-mir-451	"Leukemia, Myeloid, Chronic"	27158338	inhibition of miR-125b decreased the proliferation rates and promoted apoptosis with cell cycle arrest at the G0/G1 phase in both K562 and NB-4 cells
genetics_knock down_suppress	hsa-mir-224	Cerebral Ischemia	27165196	miR-224 inhibitor reduced neuronal cell apoptosis
genetics_knock down_suppress	hsa-mir-544a	Colorectal Carcinoma	27165435	miR-544a inhibitor and/or HOXA10 overexpression reduced lung metastases in HCT116 xenografts.
genetics_knock down_suppress	hsa-mir-592	Colorectal Carcinoma	27167185	"miR-592 inhibitor exhibited a significant reduction of migration, proliferation, and clonogenicity in CRC cells."
genetics_knock down_suppress	hsa-mir-21	Esophageal Neoplasms	27188433	"the proliferation, migration, and invasion of TE11 cells were less active in Inhibition-miR21 group."
genetics_knock down_suppress	hsa-mir-138	Intervertebral Disc Degeneration	27207584	"inhibition of miR-138-5p downregulated PTEN protein expression and promoted activation of PI3K/AKT, and knockdown of either SIRT1 or the PI3K/Akt inhibitor (LY294002) abolished the effect of miR-138-5p on NP cell apoptosis."
genetics_knock down_suppress	hsa-mir-27b	"Carcinoma, Lung, Non-Small-Cell"	27221512	introduction of miR�7b inhibitors significantly induced apoptosis and inhibited the proliferation of A549 cells.
genetics_knock down_suppress	hsa-mir-21	Liver Cirrhosis	27226339	Ad-TuD-21 administered to liver fibrosis rats could remarkably suppress profibrotic gene expression
genetics_knock down_suppress	hsa-mir-455	"Squamous Cell Carcinoma, Oral"	27235675	MiR-455-5p knockdown reduced both the anchorage-independent growth and the proliferative ability of oral cancer cells
genetics_knock down_suppress	hsa-mir-454	"Carcinoma, Lung, Non-Small-Cell"	27261580	"Down-regulation of miR-454 could significantly reduce NSCLC cell proliferation, enhance cell apoptosis, and impair cell invasion and migration in vitro, while up-regulation of miR-454 showed opposite effects."
genetics_knock down_suppress	hsa-mir-93	Cervical Neoplasms	27279231	Enforced miR-93 knockdown or RAB11FIP1 overexpression suppressed proliferation and promoted apoptosis
genetics_knock down_suppress	hsa-mir-206	Mycobacterium tuberculosis Infection	27291149	Inhibition of miR-206 markedly suppressed inflammatory cytokine secretion
genetics_knock down_suppress	hsa-mir-155	Graft-Versus-Host Disease	27296836	miR-155-/- mice showed resistance to cardiac rejection along with weakened T-cell-mediated inflammation
genetics_knock down_suppress	hsa-mir-224	Gastric Neoplasms	27315344	"inhibition of miR-224 significantly reduced the expression of mTOR and improved caspase-9/3 expression while decreased cyclin D1/2 levels, attenuating gastric cancer cell proliferation."
genetics_knock down_suppress	hsa-mir-214	Breast Neoplasms	27328731	"Depleting miR-214 or elevating miR-148b blocked the dissemination of melanoma or breast cancer cells, an effect that could be accentuated by dual alteration."
genetics_knock down_suppress	hsa-mir-214	Melanoma	27328731	"Depleting miR-214 or elevating miR-148b blocked the dissemination of melanoma or breast cancer cells, an effect that could be accentuated by dual alteration."
genetics_knock down_suppress	hsa-mir-154	Glioblastoma	27338789	Knockdown of miR-154 remarkably suppressed proliferation and migration of CD133(+) GBM cells.
genetics_knock down_suppress	hsa-mir-24	"Squamous Cell Carcinoma, Tongue"	27350307	"Inhibition of miR-24 significantly suppressed the proliferation, migration and invasion of TSCC cells in vitro."
genetics_knock down_suppress	hsa-mir-21	Colorectal Adenocarcinoma	27364574	Locked nucleic acid anti-miR-21 inhibits cell growth and invasive behaviors of a colorectal adenocarcinoma cell line
genetics_knock down_suppress	hsa-mir-155	Acute Lung Injury	27371731	miR-155 gene inactivation protected mice from LPS-induced ALI
genetics_knock down_suppress	hsa-mir-181a	"Carcinoma, Hepatocellular"	27384977	"Exogenous miR-181a expression in HepG2 cells reduced apoptosis, whereas inhibition of miR-181a in Hpe3B cells increased apoptosis."
genetics_knock down_suppress	hsa-mir-9	"Carcinoma, Breast, Triple Negative"	27402080	"miR-9 and miR-200 promoted and inhibited, respectively, the formation of vascular-like structures in vitro"
genetics_knock down_suppress	hsa-mir-23a	Macular Degeneration	27411920	Inhibition of the H2O2-induced miR-23a by antagomiR protected the RPE cells from the oxidative stress-induced cell death.
genetics_knock down_suppress	hsa-mir-18a	"Adenocarcinoma, Lung"	27412935	Downregulation of miR-18a or miR-328 can inhibit the invasion and migration abilities of A549 cells effectively.
genetics_knock down_suppress	hsa-mir-328	"Adenocarcinoma, Lung"	27412935	Downregulation of miR-18a or miR-328 can inhibit the invasion and migration abilities of A549 cells effectively.
genetics_knock down_suppress	hsa-mir-200a	Breast Neoplasms	27433802	"We further showed that inhibition of miR-200a function, mimicking the effect of calorie restriction on this microRNA, inhibited proliferation in both rat (LA7) and human (MCF7) luminal mammary cancer cell lines."
genetics_knock down_suppress	hsa-mir-942	Kaposi Sarcoma	27440900	"Suppression of miR-942-5p relieved I¦ÊB¦Á expression and reduced Vpr inhibition of KSHV replication, while overexpression of miR-942-5p enhanced Vpr inhibition of KSHV replication."
genetics_knock down_suppress	hsa-mir-10b	Endometrial Neoplasms	27447302	"The silence of miR-10b resulted in significantly enhanced cell apoptosis, and remarkably reduced cell proliferation, migration, and invasion (p��.05)."
genetics_knock down_suppress	hsa-mir-9	Prostate Neoplasms	27447934	"Inhibition of miR-9 resulted in reduced migratory and invasive potential of the M12 cell line, and reduced tumour growth and metastases in male athymic nude mice."
genetics_knock down_suppress	hsa-mir-21	Asthma	27448447	"Treatment with Ant-21, or the pan-PI3K inhibitor LY294002, reduced PI3K activity and restored HDAC2 levels. This led to suppression of airway hyperresponsiveness and restored steroid sensitivity to allergic airway disease."
genetics_knock down_suppress	hsa-mir-106b	Pituitary Neoplasms	27465551	"Down-regulation of miR-106b or up-regulation of PTEN could suppress cell proliferation and invasion of AtT-20 cells, and PTEN expression plasmid could partially simulate the function of miR-106b."
genetics_knock down_suppress	hsa-mir-155	"Carcinoma, Cervical"	27470551	"Moreover, knockdown of miR-155 was demonstrated to inhibit cell proliferation, migration, and invasion in vitro."
genetics_knock down_suppress	hsa-mir-210	Epilepsy	27471387	Our data showed that morphological changes of hippocampal neurons and apoptosis triggered by epilepsy were mitigated by miR-210 inhibition.
genetics_knock down_suppress	hsa-mir-182	"Carcinoma, Breast, Triple Negative"	27476169	Knockdown of miR-182 promotes apoptosis via regulating RIP1 deubiquitination in TNF-α-treated triple-negative breast cancer cells.
genetics_knock down_suppress	hsa-mir-137	Vascular Injuries	27497953	"Down-regulation of miR-137 ameliorates HG-induced injury in HUVECs by overexpression of AMPKα1, leading to increasing cellular reductive reactions and decreasing oxidative stress."
genetics_knock down_suppress	hsa-mir-17	Lymphoma	27498867	"Loss of miR-17/92 in Myc(+) tumor cells leads to a global decrease in tumor cell metabolism, affecting both glycolytic and mitochondrial metabolism, whereas increased miR-17/92 expression is sufficient to drive increased nutrient usage by tumor cells."
genetics_knock down_suppress	hsa-mir-126	"Carcinoma, Hepatocellular"	27499630	Inhibition of miR-126 expression increased Spred1 expression and decreased vascular endothelial growth factor expression (P<0.01).
genetics_knock down_suppress	hsa-mir-346	"Carcinoma, Nasopharyngeal"	27501413	Inhibition of miR-346 significantly attenuated the migration and invasion of NPC cells.
genetics_knock down_suppress	hsa-mir-106a	"Carcinoma, Ovarian"	27510094	Downregulation of the expression of miR-106a inhibited cell growth and metastasis of ovarian cancer cells.
genetics_knock down_suppress	hsa-mir-24	"Squamous Cell Carcinoma, Head and Neck"	27513190	"Inhibition of miR-24-3p reduced cell proliferation, colony formation efficiency and reversed chemoresistance in HNSCC cells."
genetics_knock down_suppress	hsa-mir-21	Osteosarcoma	27513462	microRNA-21 inhibition slowed proliferation and exogenously expressed microRNA-21 promoted this process.
genetics_knock down_suppress	hsa-mir-106b	"Carcinoma, Breast"	27519168	"down-regulation of miR-106b increased the expression of FUT6 and resulted in an obvious decrease of cell migration, invasion, and proliferation in MDA-MB-231 cells."
genetics_knock down_suppress	hsa-mir-127	Obesity	27532680	"On the other hand, locked nucleic acid inhibitor synthesized to target miR-127-5p significantly increased b-F1-ATPase translation efficiency in myotubes."
genetics_knock down_suppress	hsa-mir-21	Melanoma	27533779	"MiR-21 can promote the proliferation, migration, and inhibit the apoptosis of human melanoma A375 cells by inhibiting SPRY1, PDCD4, and PTEN via ERK/NF-kB signaling pathway."
genetics_knock down_suppress	hsa-mir-181a	"Carcinoma, Cervical"	27534652	Inhibition of microRNA-181a may suppress proliferation and invasion and promote apoptosis of cervical cancer cells through the PTEN/Akt/FOXO1 pathway.
genetics_knock down_suppress	hsa-mir-21	Liver Cirrhosis	27775690	Knockout of microRNA-21 reduces biliary hyperplasia and liver fibrosis in cholestatic bile duct ligated mice.
genetics_knock down_suppress	hsa-mir-322	"Carcinoma, Breast"	28404630	miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy.
genetics_knock down_suppress	hsa-mir-424	"Carcinoma, Breast"	28404630	miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy.
genetics_knock down_suppress	hsa-mir-503	"Carcinoma, Breast"	28404630	miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy.
genetics_knock down_suppress	hsa-mir-27a	Colorectal Carcinoma	28423356	Knockdown of miR-27a sensitizes colorectal cancer stem cells to TRAIL by promoting the formation of Apaf-1-caspase-9 complex.
genetics_knock down_suppress	hsa-mir-155	Infection [unspecific]	28804270	Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection
genetics_knock down_suppress	hsa-mir-29a	"Carcinoma, Breast"	29021023	Knockdown of microRNA-29a Changes the Expression of Heat Shock Proteins in Breast Carcinoma MCF-7 Cells.
genetics_knock down_suppress	hsa-mir-29a	"Carcinoma, Breast"	29435304	Knockdown of microRNA-29a regulates the expression of apoptosis-related genes in MCF-7 breast carcinoma cells
genetics_knock down_suppress	hsa-mir-21	Neoplasms [unspecific]	29540832	miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy
genetics_knock down_suppress	hsa-mir-146a	Listeriosis	29587465	MicroRNA-146a Deficiency Protects against Listeria monocytogenes Infection by Modulating the Gut Microbiota
genetics_knock down_suppress	hsa-mir-21	Colitis	29608690	Loss of microRNA-21 Influences the Gut Microbiota Causing Reduced Susceptibility in a Murine Model of Colitis
genetics_knock down_suppress	hsa-mir-21	Alcoholic Hepatitis	29848019	Knockout of microRNA-21 attenuates alcoholic hepatitis through the VHL/NF-¦ÊB signaling pathway in hepatic stellate cells.
genetics_knock down_suppress	hsa-mir-1246	"Carcinoma, Cervical"	30078258	Lentivirus media miR-1246 knockdown inhibits tumor growth and promotes apoptosis of SiHa cells
genetics_knock down_suppress	hsa-mir-299	"Carcinoma, Hepatocellular"	30266288	Knockdown of miR-299-5p inhibits the progression of hepatocellular carcinoma by targeting SIAH1.
genetics_overexpression_promote	hsa-mir-17	Lymphoma	16940181	"Mir-17-5p, also known as Mir-91,is located on chromosome 13q31; this gene is amplified in childhoodlymphoma."
genetics_overexpression_promote	hsa-mir-17	Hematologic Neoplasms	17011485	The miR-17-92 cluster is amplified in hematopoietic malignancies.
genetics_overexpression_promote	hsa-mir-18a	Hematologic Neoplasms	17011485	The miR-17-92 cluster is amplified in hematopoietic malignancies.
genetics_overexpression_promote	hsa-mir-19a	Hematologic Neoplasms	17011485	The miR-17-92 cluster is amplified in hematopoietic malignancies.
genetics_overexpression_promote	hsa-mir-19b-1	Hematologic Neoplasms	17011485	The miR-17-92 cluster is amplified in hematopoietic malignancies.
genetics_overexpression_promote	hsa-mir-20a	Hematologic Neoplasms	17011485	The miR-17-92 cluster is amplified in hematopoietic malignancies.
genetics_overexpression_promote	hsa-mir-17	Colon Neoplasms	17965831	"The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation."
genetics_overexpression_promote	hsa-mir-17	Lung Neoplasms	17965831	"The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation."
genetics_overexpression_promote	hsa-mir-18a	Colon Neoplasms	17965831	"The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation."
genetics_overexpression_promote	hsa-mir-18a	Lung Neoplasms	17965831	"The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation."
genetics_overexpression_promote	hsa-mir-19a	Colon Neoplasms	17965831	"The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation."
genetics_overexpression_promote	hsa-mir-19a	Lung Neoplasms	17965831	"The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation."
genetics_overexpression_promote	hsa-mir-19b-1	Colon Neoplasms	17965831	"The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation."
genetics_overexpression_promote	hsa-mir-19b-1	Lung Neoplasms	17965831	"The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation."
genetics_overexpression_promote	hsa-mir-20a	Colon Neoplasms	17965831	"The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation."
genetics_overexpression_promote	hsa-mir-20a	Lung Neoplasms	17965831	"The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation."
genetics_overexpression_promote	hsa-mir-92a-1	Colon Neoplasms	17965831	"The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation."
genetics_overexpression_promote	hsa-mir-92a-1	Lung Neoplasms	17965831	"The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation."
genetics_overexpression_promote	hsa-let-7g	"Carcinoma, Lung, Non-Small-Cell"	18308936	we observed significant growth reduction of both murine and human non-small cell lung tumors when overexpression of let-7g was induced from lentiviral vectors
genetics_overexpression_promote	hsa-mir-184	Squamous Cell Carcinoma	18451220	"Overexpression of miR-184 might play an oncogenic role in the antiapoptotic and proliferative processes of tongue SCC. In addition, plasma miR-184 levels were associated with the presence of primary tumor. "
genetics_overexpression_promote	hsa-mir-221	Prostate Neoplasms	19107213	miR-221: The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice
genetics_overexpression_promote	hsa-mir-222	Prostate Neoplasms	19107213	miR-222: The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice
genetics_overexpression_promote	hsa-mir-31	Leiomyosarcoma	19602040	overexpression; leads to HMGA2 overexpression; Disrupting the control of HMGA2 and let-7 pairs promotes ULMS cell growth in vitro.
genetics_overexpression_promote	hsa-mir-125a	Ovarian Neoplasms	19881956	Overexpression of miR-125a induces conversion of highly invasive ovarian cancer cells
genetics_overexpression_promote	hsa-mir-26a	Glioblastoma	20080666	"Overexpression of miR-26a in PTEN-competent and PTEN-deficient glioblastoma cells promoted tumor growth in vivo, and it further increased growth in cells overexpressing CDK4 or CENTG1."
genetics_overexpression_promote	hsa-mir-17	Neoplasms [unspecific]	20439436	mir-17:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted
genetics_overexpression_promote	hsa-mir-18a	Neoplasms [unspecific]	20439436	mir-18a:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted
genetics_overexpression_promote	hsa-mir-19a	Neoplasms [unspecific]	20439436	mir-19a:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted
genetics_overexpression_promote	hsa-mir-19b-1	Neoplasms [unspecific]	20439436	mir-19b:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted
genetics_overexpression_promote	hsa-mir-19b-2	Neoplasms [unspecific]	20439436	mir-19b:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted
genetics_overexpression_promote	hsa-mir-92a-1	Neoplasms [unspecific]	20439436	mir-92a:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted
genetics_overexpression_promote	hsa-mir-92a-2	Neoplasms [unspecific]	20439436	mir-92a:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted
genetics_overexpression_promote	hsa-mir-125b	Leukemia	21118985	"Thus, we show that overexpression of miR-125b is sufficient both to shorten the latency of BCR-ABL-induced leukemia and to independently induce leukemia in a mouse model."
genetics_overexpression_promote	hsa-mir-18a	Urinary Bladder Cancer	21388952	Specific deletion of p53 in urothelial cells is associated with specific overexpression of miR-18a and miR-19a and down-regulation of miR-107.
genetics_overexpression_promote	hsa-mir-19a	Urinary Bladder Cancer	21388952	Specific deletion of p53 in urothelial cells is associated with specific overexpression of miR-18a and miR-19a and down-regulation of miR-107.
genetics_overexpression_promote	hsa-mir-155	Hepatitis C Virus Infection	21750860	Coordinated increase of miRNA-155 and miRNA-196b expression correlates with the detection of the antigenomic strand of hepatitis C virus in peripheral blood mononuclear cells.
genetics_overexpression_promote	hsa-mir-196b	Hepatitis C Virus Infection	21750860	Coordinated increase of miRNA-155 and miRNA-196b expression correlates with the detection of the antigenomic strand of hepatitis C virus in peripheral blood mononuclear cells.
genetics_overexpression_promote	hsa-mir-125b-2	Glioblastoma	21879257	miR-125b-2 overexpression might confer glioblastoma stem cells resistance to TMZ.
genetics_overexpression_promote	hsa-mir-21	Breast Neoplasms	21917003	High expression of miR-21 in tumor stroma correlates with increased cancer cell proliferation in human breast cancer.
genetics_overexpression_promote	hsa-mir-17	"Lymphoma, Burkitt"	21981616	The minimum common amplified region on 13q was at 13q31 and included the MIR17HG (MIR17-92) locus. Samples with this gain had higher levels of MIR17 RNA and showed a tendency for early relapse.
genetics_overexpression_promote	hsa-mir-18a	"Lymphoma, Burkitt"	21981616	The minimum common amplified region on 13q was at 13q31 and included the MIR17HG (MIR17-92) locus. Samples with this gain had higher levels of MIR17 RNA and showed a tendency for early relapse.
genetics_overexpression_promote	hsa-mir-19a	"Lymphoma, Burkitt"	21981616	The minimum common amplified region on 13q was at 13q31 and included the MIR17HG (MIR17-92) locus. Samples with this gain had higher levels of MIR17 RNA and showed a tendency for early relapse.
genetics_overexpression_promote	hsa-mir-19b-1	"Lymphoma, Burkitt"	21981616	The minimum common amplified region on 13q was at 13q31 and included the MIR17HG (MIR17-92) locus. Samples with this gain had higher levels of MIR17 RNA and showed a tendency for early relapse.
genetics_overexpression_promote	hsa-mir-20a	"Lymphoma, Burkitt"	21981616	The minimum common amplified region on 13q was at 13q31 and included the MIR17HG (MIR17-92) locus. Samples with this gain had higher levels of MIR17 RNA and showed a tendency for early relapse.
genetics_overexpression_promote	hsa-mir-92a-1	"Lymphoma, Burkitt"	21981616	The minimum common amplified region on 13q was at 13q31 and included the MIR17HG (MIR17-92) locus. Samples with this gain had higher levels of MIR17 RNA and showed a tendency for early relapse.
genetics_overexpression_promote	hsa-mir-10b	Pancreatic Neoplasms	22018284	"MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis."
genetics_overexpression_promote	hsa-mir-17	Colon Neoplasms	22065543	"MiR-17-92 cluster and its paralogs were significantly overexpressed in colon tumor. No significant associations were found between the deregulation of certain miRNAs and the clinical and pathologic characteristics observed in patients. Kaplan-Meier curves demonstrated significantly reduced overall survival in patients expressing high levels of miR-17. In multivariate Cox models, miR-17 overexpression (HR 2.67; P=0.007) and TNM staging (HR 8.87; P=0.002) were significantly associated with a risk of death."
genetics_overexpression_promote	hsa-mir-18a	Colon Neoplasms	22065543	"MiR-17-92 cluster and its paralogs were significantly overexpressed in colon tumor. No significant associations were found between the deregulation of certain miRNAs and the clinical and pathologic characteristics observed in patients. Kaplan-Meier curves demonstrated significantly reduced overall survival in patients expressing high levels of miR-17. In multivariate Cox models, miR-17 overexpression (HR 2.67; P=0.007) and TNM staging (HR 8.87; P=0.002) were significantly associated with a risk of death."
genetics_overexpression_promote	hsa-mir-19a	Colon Neoplasms	22065543	"MiR-17-92 cluster and its paralogs were significantly overexpressed in colon tumor. No significant associations were found between the deregulation of certain miRNAs and the clinical and pathologic characteristics observed in patients. Kaplan-Meier curves demonstrated significantly reduced overall survival in patients expressing high levels of miR-17. In multivariate Cox models, miR-17 overexpression (HR 2.67; P=0.007) and TNM staging (HR 8.87; P=0.002) were significantly associated with a risk of death."
genetics_overexpression_promote	hsa-mir-19b-1	Colon Neoplasms	22065543	"MiR-17-92 cluster and its paralogs were significantly overexpressed in colon tumor. No significant associations were found between the deregulation of certain miRNAs and the clinical and pathologic characteristics observed in patients. Kaplan-Meier curves demonstrated significantly reduced overall survival in patients expressing high levels of miR-17. In multivariate Cox models, miR-17 overexpression (HR 2.67; P=0.007) and TNM staging (HR 8.87; P=0.002) were significantly associated with a risk of death."
genetics_overexpression_promote	hsa-mir-20a	Colon Neoplasms	22065543	"MiR-17-92 cluster and its paralogs were significantly overexpressed in colon tumor. No significant associations were found between the deregulation of certain miRNAs and the clinical and pathologic characteristics observed in patients. Kaplan-Meier curves demonstrated significantly reduced overall survival in patients expressing high levels of miR-17. In multivariate Cox models, miR-17 overexpression (HR 2.67; P=0.007) and TNM staging (HR 8.87; P=0.002) were significantly associated with a risk of death."
genetics_overexpression_promote	hsa-mir-92a-1	Colon Neoplasms	22065543	"MiR-17-92 cluster and its paralogs were significantly overexpressed in colon tumor. No significant associations were found between the deregulation of certain miRNAs and the clinical and pathologic characteristics observed in patients. Kaplan-Meier curves demonstrated significantly reduced overall survival in patients expressing high levels of miR-17. In multivariate Cox models, miR-17 overexpression (HR 2.67; P=0.007) and TNM staging (HR 8.87; P=0.002) were significantly associated with a risk of death."
genetics_overexpression_promote	hsa-mir-125b-1	Rhinosinusitis	22071331	"Overexpression of miR-125b, a Novel Regulator of Innate Immunity, in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps."
genetics_overexpression_promote	hsa-mir-125b-2	Rhinosinusitis	22071331	"Overexpression of miR-125b, a Novel Regulator of Innate Immunity, in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps."
genetics_overexpression_promote	hsa-mir-155	"Carcinoma, Hepatocellular"	22071603	Up-regulation of microRNA-155 promotes cancer cell invasion and predicts poor survival of hepatocellular carcinoma following liver transplantation.
genetics_overexpression_promote	hsa-mir-223	"Squamous Cell Carcinoma, Esophageal"	22108521	Overexpression of microRNA-223 regulates the ubiquitin ligase FBXW7 in oesophageal squamous cell carcinoma.
genetics_overexpression_promote	hsa-mir-124-1	Neuroblastoma	22123030	"Ectopic overexpression of miR-124 resulted in the downregulation of CDK6, decreased cellular proliferation, and induced cellular morphological changes."
genetics_overexpression_promote	hsa-mir-124-2	Neuroblastoma	22123030	"Ectopic overexpression of miR-124 resulted in the downregulation of CDK6, decreased cellular proliferation, and induced cellular morphological changes."
genetics_overexpression_promote	hsa-mir-124-3	Neuroblastoma	22123030	"Ectopic overexpression of miR-124 resulted in the downregulation of CDK6, decreased cellular proliferation, and induced cellular morphological changes."
genetics_overexpression_promote	hsa-mir-122	"Carcinoma, Hepatocellular"	22140464	"miR-122 expression is highly elevated in quiescent human primary hepatocytes (hPHs) but lost or attenuated in hESCs and HCCs, while an opposing expression pattern is observed for Pkm2. Depleting hESCs and HCCs of Pkm2, or overexpressing miR-122, leads to a common deficiency in self-renewal and proliferation."
genetics_overexpression_promote	hsa-mir-223	"Leukemia, Lymphocytic, Chronic, B-Cell"	22145958	microRNA-223 expression is uniformly down-regulated in B cell lymphoproliferative disorders and is associated with poor survival in chronic lymphocytic leukemia patients.
genetics_overexpression_promote	hsa-mir-200a	Prostate Neoplasms	22161972	"miR-200a overexpression reduced prostate cancer cell growth and may have potential, in combination with other markers, in stratifying prostate cancer patients for more intensive monitoring and therapy."
genetics_overexpression_promote	hsa-mir-28	Colorectal Carcinoma	22240480	"miR-28-5p altered expression of CCND1 and HOXB3, whereas miR-28-3p bound NM23-H1. Overexpression of miR-28-5p reduced CRC cell proliferation, migration, and invasion in vitro, whereas miR-28-3p increased CRC cell migration and invasion in vitro."
genetics_overexpression_promote	hsa-mir-182	Ovarian Neoplasms	22322863	"miR-182 overexpression resulted in increased tumor transformation in vitro, and enhanced tumor invasiveness in vitro and metastasis in vivo. The oncogenic properties of miR-182 in ovarian cancer were mediated in part by its impaired repair of DNA double-strand breaks and negative regulation of breast cancer 1 (BRCA1) and metastasis suppressor 1 (MTSS1) expressions as well as its positive regulation of oncogene high-mobility group AT-hook 2 (HMGA2)."
genetics_overexpression_promote	hsa-mir-21	"Carcinoma, Lung, Non-Small-Cell"	22335905	Overexpression of miR-21 promotes proliferation and reduces apoptosis in non-small cell lung cancer].
genetics_overexpression_promote	hsa-mir-34a	Myocardial Infarction	22403243	"IGF-1 significantly inhibited H(2)O(2)-induced miR-34a expression, and miR-34a overexpression abolished the anti-apoptotic effect of IGF-1."
genetics_overexpression_promote	hsa-mir-17	Leukemia	22451425	"In both murine and human leukemias, p53 inactivation contributed to the selective overexpression of oncogenic miR-92a and miR-19a, and down-regulation of tumor-suppressive miR-17."
genetics_overexpression_promote	hsa-mir-19a	Acute Erythroid Leukemia	22451425	"overexpression of individual miRNAs from this locus, miR-19a or miR-92a, results in B-cell hyperplasia and erythroleukemia, respectively."
genetics_overexpression_promote	hsa-mir-92a	Acute Erythroid Leukemia	22451425	"overexpression of individual miRNAs from this locus, miR-19a or miR-92a, results in B-cell hyperplasia and erythroleukemia, respectively."
genetics_overexpression_promote	hsa-mir-130a	Ovarian Neoplasms	22455133	The over expression of miR-130a is associated with cisplatin resistance of ovarian cancer. Inhibiting miR-130a expression may help reverse the cisplatin resistance of ovarian cancer.
genetics_overexpression_promote	hsa-mir-21	Breast Neoplasms	22547075	DNA damage induces NF-kB-dependent microRNA-21 upregulation and promotes breast cancer cell invasion.
genetics_overexpression_promote	hsa-mir-125b	"Leukemia, Myeloid, Acute"	22689670	"We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that transplantation of mice with murine stem/progenitor cells overexpressing miR-125b is able to induce leukemia."
genetics_overexpression_promote	hsa-mir-615	"Carcinoma, Hepatocellular"	22819824	miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma.
genetics_overexpression_promote	hsa-mir-221	Thyroid Neoplasms	22855362	Overexpression of miR-221 is associated with aggressive clinicopathologic characteristics and the BRAF mutation in papillary thyroid carcinomas.
genetics_overexpression_promote	hsa-mir-132	Heart Failure	23011132	"MiR-212/132 null mice are protected from pressure-overload-induced heart failure, whereas cardiomyocyte-specific overexpression of the miR-212/132 family leads to pathological cardiac hypertrophy, heart failure and death in mice."
genetics_overexpression_promote	hsa-mir-212	Heart Failure	23011132	"MiR-212/132 null mice are protected from pressure-overload-induced heart failure, whereas cardiomyocyte-specific overexpression of the miR-212/132 family leads to pathological cardiac hypertrophy, heart failure and death in mice."
genetics_overexpression_promote	hsa-mir-221	Inflammation	23023232	"The overexpression of oncogenic miR-221 and miR-222 caused by HMGB1 is associated with an increase in malignancy scores, namely cell growth and motility."
genetics_overexpression_promote	hsa-mir-222	"Carcinoma, Thyroid, Papillary"	23023232	"The overexpression of oncogenic miR-221 and miR-222 caused by HMGB1 is associated with an increase in malignancy scores, namely cell growth and motility."
genetics_overexpression_promote	hsa-mir-17	Gastric Neoplasms	23333058	"Overexpression of miR-17-5p/20a promoted gastric cancer cell cycle progression and inhibited cell apoptosis, whereas knockdown of miR-17-5p/20a resulted in cell cycle arrest and increased apoptosis."
genetics_overexpression_promote	hsa-mir-20a	Gastric Neoplasms	23333058	"Overexpression of miR-17-5p/20a promoted gastric cancer cell cycle progression and inhibited cell apoptosis, whereas knockdown of miR-17-5p/20a resulted in cell cycle arrest and increased apoptosis."
genetics_overexpression_promote	hsa-mir-100	"Carcinoma, Renal Cell"	23378187	miR-100 overexpression strongly associates with advanced tumor progression and unfavorable clinical outcome of patients with RCC
genetics_overexpression_promote	hsa-mir-106b	"Carcinoma, Hepatocellular"	23483935	Over-Expression of miR-106b Promotes Cell Migration and Metastasis in Hepatocellular Carcinoma by Activating Epithelial-Mesenchymal Transition Process
genetics_overexpression_promote	hsa-mir-449a	"Adenocarcinoma, Lung"	23614048	"Overexpression of miR-449a in CL1-0 cells effectively increased irradiation-induced DNA damage and apoptosis,altered the cell cycle distribution and eventually led to sensitization of CL1-0 to irradiation."
genetics_overexpression_promote	hsa-mir-1	Myocardial Infarction	23615185	Overexpression of MicroRNA-1 improves the efficacy of mesenchymal stem cell transplantation after myocardial infarction.
genetics_overexpression_promote	hsa-mir-146a	Sepsis	23638011	Overexpression of miR-146a induces a state analogous to tolerance in BLP-stimulated cells and therefore may represent a future target for exogenous modulation of tolerance during microbial infection and sepsis.
genetics_overexpression_promote	hsa-mir-9	Leukemia	23798388	miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia.
genetics_overexpression_promote	hsa-mir-146b	Inflammation	23813877	MicroRNA-146b improves intestinal injury in mouse colitis by activating nuclear factor-¦ÊB and improving epithelial barrier function.
genetics_overexpression_promote	hsa-mir-22	Heart Failure	24086656	microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription.
genetics_overexpression_promote	hsa-mir-449a	Retinoblastoma	24120948	We are the first to confirm an inhibitory effect of miR-449a and -449b in retinoblastoma by demonstrating significantly impaired proliferation and increased apoptosis of tumor cells when these miRNAs are overexpressed.
genetics_overexpression_promote	hsa-mir-32	Colorectal Carcinoma	24123284	"MiR-32 overexpression was correlated with specific CRC clinicopathological features and may be a marker of poor prognosis in CRC patients. MiR-32 and PTEN expression were inversely correlated, and miR-32 may be associated with the development of CRC."
genetics_overexpression_promote	hsa-mir-17	Leukemia	24145403	"The miR-17?92 overexpression was driven by the E?-enhancer and Ig heavy-chain promoter, and a 3' GFP tag was added to the transgene to track the miR expression."
genetics_overexpression_promote	hsa-mir-18a	"Leukemia, B-Cell"	24145403	"The miR-17?92 overexpression was driven by the E?-enhancer and Ig heavy-chain promoter, and a 3' GFP tag was added to the transgene to track the miR expression."
genetics_overexpression_promote	hsa-mir-19a	"Leukemia, B-Cell"	24145403	"The miR-17?92 overexpression was driven by the E?-enhancer and Ig heavy-chain promoter, and a 3' GFP tag was added to the transgene to track the miR expression."
genetics_overexpression_promote	hsa-mir-19b	"Leukemia, B-Cell"	24145403	"The miR-17?92 overexpression was driven by the E?-enhancer and Ig heavy-chain promoter, and a 3' GFP tag was added to the transgene to track the miR expression."
genetics_overexpression_promote	hsa-mir-92a	"Leukemia, B-Cell"	24145403	"The miR-17?92 overexpression was driven by the E?-enhancer and Ig heavy-chain promoter, and a 3' GFP tag was added to the transgene to track the miR expression."
genetics_overexpression_promote	hsa-mir-21	Colorectal Carcinoma	24149370	"miR-21 is a key player in oncogenic EMT, its overexpression is controlled by the cooperation of genetic and epigenetic alterations, and its levels, along with ITG¦Â4 and PDCD4 expression, could be exploited as a prognostic tool for CRC metastasis."
genetics_overexpression_promote	hsa-mir-18a	Toxic Epidermal Necrolysis	24184144	Our results indicated that downregulated BCL2L10 caused by miR-18a-5p overexpression mediates intrinsic keratinocyte apoptosis in patients with TEN. Serum miR-18a-5p levels can be a useful disease marker for drug eruptions.
genetics_overexpression_promote	hsa-let-7a	Systemic Lupus Erythematosus	24240124	our results suggest that overexpression of let-7a may contribute to hyperplasia and the proinflammatory response in SLE.
genetics_overexpression_promote	hsa-mir-296	Prostate Neoplasms	24263102	"Interestingly, ectopic expression of miR-296-3p in P69 increases the tolerance to NK cells whereas knockdown of miR-296-3p in M12 reduces the resistance to NK cells, which both phenotypes can be rescued by re-expression or silencing of ICAM-1 in P69 and M12, respectively."
genetics_overexpression_promote	hsa-mir-9	Pulmonary Hypertension	24615545	"Knockdown of miR-9 followed by hypoxia exposure attenuated PASMCs proliferation and enhanced the expression of contractile genes in vascular smooth muscle cells (VSMCs), while overexpression of miR-9 in normoxia promoted a proliferative phenotype in PASMCs."
genetics_overexpression_promote	hsa-mir-210	Gastrointestinal Stromal Tumor	24623741	"Overexpression of miR-210 is associated with SDH-related pheochromocytomas, paragangliomas, and gastrointestinal stromal tumours."
genetics_overexpression_promote	hsa-mir-125a	Myelodysplastic Syndromes	24690917	Overexpression of miR-125a in myelodysplastic syndrome CD34+ cells modulates NF-¦ÊB activation and enhances erythroid differentiation arrest.
genetics_overexpression_promote	hsa-mir-30c	Heart Failure	24789369	Taken together these data indicate impaired mitochondrial function due to OXPHOS protein depletion as a potential cause for the observed dilated cardiomyopathic phenotype in miRNA-30c transgenic mice.
genetics_overexpression_promote	hsa-mir-429	Ovarian Neoplasms	24802724	Ectopic over-expression of miR-429 induces mesenchymal-to-epithelial transition (MET) and increased drug sensitivity in metastasizing ovarian cancer cells.
genetics_overexpression_promote	hsa-mir-30a	Nasopharyngeal Neoplasms	24812123	"Furthermore, over-expression of miR-30a transfected with precursor increased the ability of metastasis and invasion of NPC tumor cells in vivo and in vitro."
genetics_overexpression_promote	hsa-mir-222	"Carcinoma, Hepatocellular"	24955159	"MiR-222 overexpression induced an enhancement of HepG2 cell proliferation in vitro, paralleling with an altered cell cycle progression via increased cell population in S phase."
genetics_overexpression_promote	hsa-mir-23b	Breast Neoplasms	24966325	Ectopic expression of the miRNAs in the weakly metastatic mouse 4TO7 mammary tumor cell line had no effect on proliferation or morphology of tumor cells in vitro but was found to increase lung metastasis in a mouse model of breast cancer metastasis.
genetics_overexpression_promote	hsa-mir-24	Breast Neoplasms	24966325	Ectopic expression of the miRNAs in the weakly metastatic mouse 4TO7 mammary tumor cell line had no effect on proliferation or morphology of tumor cells in vitro but was found to increase lung metastasis in a mouse model of breast cancer metastasis.
genetics_overexpression_promote	hsa-mir-27b	Breast Neoplasms	24966325	Ectopic expression of the miRNAs in the weakly metastatic mouse 4TO7 mammary tumor cell line had no effect on proliferation or morphology of tumor cells in vitro but was found to increase lung metastasis in a mouse model of breast cancer metastasis.
genetics_overexpression_promote	hsa-mir-9	Osteosarcoma	24969351	"The findings of our study suggest that increased miR-9 expression has a strong correlation with the aggressive progression of osteosarcoma and its overexpression is a statistically significant risk factor affecting overall survival, suggesting that increased miR-9 expression could be a valuable marker of tumor progression and for prognosis of osteosarcoma."
genetics_overexpression_promote	hsa-mir-17	Gastric Neoplasms	25047501	Overexpression of miR-17 in gastric cancer is correlated with proliferation-associated oncogene amplification.
genetics_overexpression_promote	hsa-mir-214	Cardiomegaly	25085702	Cardiac hypertrophy and dysfunction induced by overexpression of miR-214 in vivo.
genetics_overexpression_promote	hsa-mir-195	Heart Failure	25100012	Cardiac overexpression of miR-195 results in pathological cardiac growth and heart failure in transgenic mice.
genetics_overexpression_promote	hsa-mir-146a	Breast Neoplasms	25123132	Overexpression of miR-146a in basal-like breast cancer cells confers enhanced tumorigenic potential in association with altered p53 status.
genetics_overexpression_promote	hsa-mir-21	Gastric Neoplasms	25230738	"This meta-analysis indicates that miR-21 detection has a prognostic value in patients with gastric cancer. In addition, overexpression of miR-21 is associated with worse tumor differentiation, lymph node metastasis, and TNM stage."
genetics_overexpression_promote	hsa-mir-196a	Oral Neoplasms	25233933	"Functionally, miR-196 actively promoted cell migration and invasion without affecting cell growth."
genetics_overexpression_promote	hsa-mir-21	Neoplasms [unspecific]	25241894	Ectopic expression of miR-21 and miR-29a promotes angiogenesis and tumor cell proliferation
genetics_overexpression_promote	hsa-mir-223	Colorectal Carcinoma	25270282	Overexpression of miR-223 correlates with tumor metastasis and poor prognosis in patients with colorectal cancer.
genetics_overexpression_promote	hsa-mir-410	Colorectal Carcinoma	25272045	MiR-410 is overexpressed in liver and colorectal tumors and enhances tumor cell growth by silencing FHL1 via a direct/indirect mechanism.
genetics_overexpression_promote	hsa-mir-374a	Neoplasms [unspecific]	25299640	The miR-545/374a cluster encoded in the Ftx lncRNA is overexpressed in HBV-related hepatocellular carcinoma and promotes tumorigenesis and tumor progression.
genetics_overexpression_promote	hsa-mir-545	Neoplasms [unspecific]	25299640	The miR-545/374a cluster encoded in the Ftx lncRNA is overexpressed in HBV-related hepatocellular carcinoma and promotes tumorigenesis and tumor progression.
genetics_overexpression_promote	hsa-mir-200c	Breast Neoplasms	25329395	Overexpression of microRNA-200c predicts poor outcome in patients with PR-negative breast cancer.
genetics_overexpression_promote	hsa-mir-184	"Squamous Cell Carcinoma, Head and Neck"	25351569	Treatment with the precursors of these miRNAs increases the proliferation and migration of HNSCC cells.
genetics_overexpression_promote	hsa-mir-1269	"Carcinoma, Hepatocellular"	25472505	"overexpression of miR-1269 promotes cell proliferation in HCC through directly suppressing FOXO1, and functions as an oncomiR in HCC."
genetics_overexpression_promote	hsa-mir-17	Hematologic Neoplasms	25597017	overexpression of miR-17-92 in a limited number of hematopoietic cells is sufficient to cause B cell malignancies.
genetics_overexpression_promote	hsa-mir-34a	Sensorineural Hearing Loss	25638533	"In the inner ear HEI-OC1 cell line, miR-34a overexpression inhibited SIRT1, leading to an increase in p53 acetylation and apoptosis."
genetics_overexpression_promote	hsa-mir-29c	Brain Disease [unspecific]	25678279	"over-expression of miR-29c effectively reduced Birc2 (also Bak1) mRNA and protein levels, increased infarct volume and apoptosis, and deteriorated neurological outcomes, whereas down-regulation played a neuroprotective role."
genetics_overexpression_promote	hsa-mir-433	Ovarian Neoplasms	25684390	Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells.
genetics_overexpression_promote	hsa-mir-221	Neoplasms [unspecific]	25686829	Over-expression of miR-221 stimulated stem-like cells in luminal type of cancer and the miR-221 level was correlated with clinical outcome in breast cancer patients.
genetics_overexpression_promote	hsa-mir-153	"Carcinoma, Hepatocellular"	25714700	Over-expression of miR-153 down-regulated the activity of Etoposide and Paclitaxel on cell cycle arrest of HepG2 cells and the effect of Sorafenib on the invasion and migration of HepG2 cells.
genetics_overexpression_promote	hsa-mir-196a	"Squamous Cell Carcinoma, Head and Neck"	25860510	"These results show that miR-196a and HOXB9 are overexpressed,perhaps co-ordinately, as HNSCC develops and exert a pro-tumourigenic phenotype in HNSCC and OPM cells."
genetics_overexpression_promote	hsa-mir-21	"Carcinoma, Cervical"	25963606	Overexpression of miR-21 promotes the proliferation and migration of cervical cancer cells via the inhibition of PTEN.
genetics_overexpression_promote	hsa-mir-125a	Chronic Hepatitis B	25993287	"Conversely, the overexpression of miR-125a or knockdown of A20 mimicked HBx to enhance TRAIL susceptibility in hepatocytes."
genetics_overexpression_promote	hsa-mir-196a	Osteosarcoma	26045752	"Taken together, miR-196a should be an oncogene in osteosarcoma. The possible mechanism was that overexpression of miR-196a promoted proliferation of MG63 and U2OS cells by modulating the PTEN/PI3K/Akt signaling pathway."
genetics_overexpression_promote	hsa-mir-221	"Carcinoma, Lung, Non-Small-Cell"	26131134	We found that miR-222 overexpression increased cell viability and proliferative rate in H460 cells while opposite effects were obtained by down-regulation of miR-222.
genetics_overexpression_promote	hsa-mir-144	Diabetic Cardiomyopathies	26164195	The miR-144 mimics aggravated high glucose-induced ROS formation and apoptosis in cardiomyocytes
genetics_overexpression_promote	hsa-mir-23a	"Carcinoma, Laryngeal"	26171041	"Ectopic expression of miR-23a and knockdown of APAF-1 significantly promoted cell proliferation and colony formation, and inhibited early apoptosis in Hep2 cells."
genetics_overexpression_promote	hsa-mir-132	"Diabetes Mellitus, Type 2"	26218441	Overexpression of miR-132 or miR-212 enhances glucose and GLP-1-stimulated insulin secretion.
genetics_overexpression_promote	hsa-mir-212	"Diabetes Mellitus, Type 2"	26218441	Overexpression of miR-132 or miR-212 enhances glucose and GLP-1-stimulated insulin secretion.
genetics_overexpression_promote	hsa-mir-331	Prostate Neoplasms	26259043	"Overexpression of miR-331-3p upregulated mesenchymal markers such as vimentin, N-cadherin, and snail and downregulated epithelial markers such as E-cadherin and desmoplakin in the prostate cancer cell line PC3."
genetics_overexpression_promote	hsa-mir-93	"Squamous Cell Carcinoma, Esophageal"	26273410	"The introduction of miR-93 significantly promotes cell proliferation,cell cycle progression, and the metastatic capability of EC109 cells. "
genetics_overexpression_promote	hsa-mir-20a	Gastric Neoplasms	26286834	"ectopic expression of miR-20a dramatically decreased the expression of NFKBIB; increased the expression of p65, livin, and survivin"
genetics_overexpression_promote	hsa-mir-215	Glioma	26317904	"In summary, miR-215 is overexpressed in human glioma, is involved in TGF-¦Â1-induced oncogenesis, and can be used as a marker of poor prognosis in glioma patients."
genetics_overexpression_promote	hsa-mir-206	Cardiomegaly	26333362	Cardiac-specific overexpression of miR-206 in mice induced hypertrophy and protected the heart from ischemia/reperfusion injury
genetics_overexpression_promote	hsa-mir-1207	Ovarian Neoplasms	26337084	MiR-1207 overexpression promotes cancer stem cell-like traits in ovarian cancer by activating the Wnt/¦Â-catenin signaling pathway.
genetics_overexpression_promote	hsa-mir-302	Fanconi Anemia	26343459	"Taken together, our results suggest that overexpression of miR-302 plays a critical role in the regulation of FANCD2 monoubiquitination, resulting in characteristic defects in DNA repair within cells."
genetics_overexpression_promote	hsa-mir-92a	"Carcinoma, Lung, Non-Small-Cell"	26432332	"upregulation of miR-92a in NSCLC cells promoted cell proliferation, migration, and invasion, decreased apoptosis and caspase-3 activity, and enhanced chemoresistance of NSCLC cells, whereas downregulation of miR-92a showed the opposite effects."
genetics_overexpression_promote	hsa-mir-451	"Squamous Cell Carcinoma, Head and Neck"	26506880	And overexpression of miRNA-451 in cells with low endogenous expression of miRNA-451 accelerated proliferation.
genetics_overexpression_promote	hsa-mir-664	Osteosarcoma	26515813	Overexpression of miR-664 was associated with increased migration and invasive abilities of OS cells in vitro
genetics_overexpression_promote	hsa-mir-221	Inflammation	26549234	Enforced expression of miR-221 significantly increased the production of proinflammatory cytokines
genetics_overexpression_promote	hsa-mir-21	Asthma	26651881	"This study provides the first in vitro evidence that overexpression of miR-21 in HASM cells can trigger cell proliferation and migration, and the effects of miR-21 depend on the level of PTEN."
genetics_overexpression_promote	hsa-mir-27b	Cervical Neoplasms	26706910	"Upregulation of miR-27b significantly accelerated the proliferation, cell cycle transition from G1 to S phase, migration and invasion of C33A cells"
genetics_overexpression_promote	hsa-mir-183	Colorectal Carcinoma	26717041	"over-expression of miR-183 resulted in the attenuation of rapamycin- or starvation-induced autophagy in cancer cells, whereas inhibition of endogenous miR-183 stimulated autophagy and apoptosis."
genetics_overexpression_promote	hsa-mir-200a	"Carcinoma, Nasopharyngeal"	26718506	Overexpression of miR-200a resulted in the proliferation of CNE2 cells.
genetics_overexpression_promote	hsa-mir-203	Pancreatic Neoplasms	26719072	"miR-203 promotes proliferation, migration and invasion in pancreatic cancer cells"
genetics_overexpression_promote	hsa-mir-421	Osteosarcoma	26758431	"overexpression of miR-421 promoted osteosarcoma cell line MG-63 proliferation, migration, and invasion."
genetics_overexpression_promote	hsa-mir-21	Osteosarcoma	26779632	miR-21 overexpression in MG63 caused a significant raise in cell proliferation and invasion and a significant reduction in cell apoptosis.
genetics_overexpression_promote	hsa-mir-222	Bladder Neoplasms	26800397	Overexpression of miR-222 attenuated cisplatin-induced cell death in bladder cancer cells.
genetics_overexpression_promote	hsa-mir-96	Glioma	26846266	"In vivo, microRNA-96 overexpression inhibits the apoptosis and increases tumor growth."
genetics_overexpression_promote	hsa-mir-21	Heart Failure	26865549	Overexpression of miR-21 in this monocyte cell line activated a fibrotic gene programme and promoted monocyte-to-fibrocyte transition
genetics_overexpression_promote	hsa-mir-183	Glioma	26879754	"Introduction of miR-183 mimics into U251 cells could promoted, while its antisense oligos inhibited cell proliferation and invasion."
genetics_overexpression_promote	hsa-mir-205	"Carcinoma, Nasopharyngeal"	26880795	"Overexpression of miR-205 increased the proliferation, migration and invasion of CNE2 cells"
genetics_overexpression_promote	hsa-mir-21	"Carcinoma, Cervical"	26884851	"The overexpression of HPV E7 protein facilitated the expression of miR-21, which potentiated Hela cell proliferation and invasion."
genetics_overexpression_promote	hsa-mir-138	Glioblastoma	26887050	Transient transfection of miR-138 mimics in glioma cells with low basal miR-138 expression increased glioma cell proliferation.
genetics_overexpression_promote	hsa-mir-27b	Cervical Neoplasms	26910911	"MiR-27b, up-regulated by E7, promoted CaSki and SiHa cell proliferation and invasion, inhibit paclitaxel-induced apoptosis."
genetics_overexpression_promote	hsa-mir-195	Spinal Cord Injuries	26927342	"In addition, Ad-miR-195 also obviously increased the number of apoptotic cells and decreased the neurological recovery in the animals injected with Ad-miR-195."
genetics_overexpression_promote	hsa-mir-449a	Breast Neoplasms	26934316	"In vitro, miR-449a promoted breast cancer cell proliferation, clonogenic survival, migration, and invasion."
genetics_overexpression_promote	hsa-mir-214	Breast Neoplasms	26951965	the overexpression of miR�14 markedly increased cell viability and abrogated the apoptosis triggered by serum starvation
genetics_overexpression_promote	hsa-mir-522	"Carcinoma, Hepatocellular"	26960688	"miR-522 overexpression promoted cell proliferation, colony formation, and cell cycle progression, whereas knockdown of miR-522 reduced these effects."
genetics_overexpression_promote	hsa-mir-210	Kidney Neoplasms	26985942	ACHN cell proliferation and invasion were significantly increased and apoptosis was significantly decreased (P < 0.05) when miR-210 was overexpressed.
genetics_overexpression_promote	hsa-mir-146a	Chronic Hepatitis B	26996068	Overexpression of miR-146a reduced NK cell-mediated cytotoxicity
genetics_overexpression_promote	hsa-mir-141	"Carcinoma, Nasopharyngeal"	27010857	ectopic expression of miR-141 can significantly promote cell proliferation and inhibit apoptosis in NPC
genetics_overexpression_promote	hsa-mir-125a	Juvenile Rheumatoid Arthritis	27014994	miR-125a-5p overexpression enhanced M2b polarization and altered other polarized populations
genetics_overexpression_promote	hsa-mir-195	Myocardial Ischemic-Reperfusion Injury	27019437	"miR-195 expression was upregulated in myocardial I/R injury, and miR-195 overexpression may promote cardiomyocyte apoptosis by targeting Bcl-2 and inducing mitochondrial apoptotic pathway."
genetics_overexpression_promote	hsa-mir-93	"Carcinoma, Gastric"	27021515	miR-93 promoted the development of gastric tumor growth in xenograft mice
genetics_overexpression_promote	hsa-mir-9	Glioblastoma	27036038	"hsa-miR-9 overexpression leads to MAPKAP signaling inhibition, partially by interfering with the MAPK14/MAPKAP3 complex. Further, hsa-miR-9 overexpression initiates re-arrangement of actin filament"
genetics_overexpression_promote	hsa-mir-221	Breast Neoplasms	27044817	"Enforced expression of miR-221/222 promoted breast cancer cell proliferation, migration and invasion via targeting PTEN/Akt pathway."
genetics_overexpression_promote	hsa-mir-222	Breast Neoplasms	27044817	"Enforced expression of miR-221/222 promoted breast cancer cell proliferation, migration and invasion via targeting PTEN/Akt pathway."
genetics_overexpression_promote	hsa-mir-373	"Squamous Cell Carcinoma, Esophageal"	27073718	"Overexpression of miR-373 in ECA109 cells enhanced proliferation, G1-phase cell proportion, migration, and invasion."
genetics_overexpression_promote	hsa-mir-141	Breast Neoplasms	27075851	"Ectopic expression of miR-141 in nonexpressing MDA-MB-231 enhanced brain metastatic colonization (5/9 mice vs 0/10 mice,P= .02)."
genetics_overexpression_promote	hsa-mir-92b	"Carcinoma, Hepatocellular"	27100897	miR-92b could promote cell proliferation and metastasis of HCC in vitro and in vivo.
genetics_overexpression_promote	hsa-mir-146a	Multiple Myeloma	27102001	"overexpressing miR-146a in MSC, secretion of several cytokines and chemokines including CXCL1, IL6, IL-8, IP-10, MCP-1, and CCL-5 was elevated, resulting in the enhancement of MM cell viability and migration."
genetics_overexpression_promote	hsa-mir-196a	"Carcinoma, Hepatocellular"	27108614	"HCV core protein increased the expression of miR�96a, and that overexpression of miR�96a in the HepG2 and Huh� HCC cell lines promoted cell proliferation by inducing the G1‑S transition."
genetics_overexpression_promote	hsa-mir-449a	Hepatitis B Virus Infection	27138288	"Ectopic miR-449a expression in HCC cells strongly enhanced HBV replication, transcription, progeny virions secretion, and antigen expression in a dose-dependent manner."
genetics_overexpression_promote	hsa-mir-106a	Gastric Neoplasms	27142596	"Abnormal over-expression of miR-106a significantly promoted gastric cancer cell proliferation, metastasis, inhibited the cell apoptosis."
genetics_overexpression_promote	hsa-mir-96	"Carcinoma, Prostate"	27164937	Overexpressing miR-96 led to increased proliferation and colony formation of normal prostate epithelial cells.
genetics_overexpression_promote	hsa-mir-410	Colorectal Carcinoma	27177325	overexpression of miR�10 resulted in an increase in growth activity and decrease in the extent of apoptosis
genetics_overexpression_promote	hsa-mir-937	Lung Neoplasms	27179609	Overexpression of miR-937 in A549 promoted anchorage -dependent and -independent growth
genetics_overexpression_promote	hsa-mir-200b	"Cytotoxicity Tests, Immunologic"	27183614	Cells overexpressing miR-200b/c or miR-217 showed reduced sensitivity to CDC
genetics_overexpression_promote	hsa-mir-200c	"Cytotoxicity Tests, Immunologic"	27183614	Cells overexpressing miR-200b/c or miR-217 showed reduced sensitivity to CDC
genetics_overexpression_promote	hsa-mir-217	"Cytotoxicity Tests, Immunologic"	27183614	Cells overexpressing miR-200b/c or miR-217 showed reduced sensitivity to CDC
genetics_overexpression_promote	hsa-mir-182	Liver Injury	27196584	"miR-182, which is associated with disease severity and liver injury."
genetics_overexpression_promote	hsa-mir-126	"Neovascularization, Pathologic"	27203443	"silencing of miR-126-3p repressed angiogenesis, while overexpression of miR-126-5p enhanced angiogenesis."
genetics_overexpression_promote	hsa-mir-21	Hypertrophic Scar	27207585	overexpression of miR-21 promoted fibroproliferative expression in fibroblasts.
genetics_overexpression_promote	hsa-mir-125b	"Carcinoma, Gastric"	27220320	Overexpression of miR-125b promoted gastric cancer cell migration and invasion in vitro and metastasis in vivo.
genetics_overexpression_promote	hsa-mir-211	"Squamous Cell Carcinoma, Oral"	27221705	Induction of oral carcinogenesis in transgenic mice using 4-nitroquinoline 1-oxide (4NQO) resulted in more extensive and severe tongue tumorigenesis compared with control animals.
genetics_overexpression_promote	hsa-mir-221	"Adenocarcinoma, Pancreatic Ductal"	27230035	Overexpressing miR-221 significantly increased cell vitality and promoted cell proliferation and G1-to-S phase transition of the cell cycle in Capan-2 cells
genetics_overexpression_promote	hsa-mir-146a	Alzheimer Disease	27241555	"Overexpression of miRNA-146a in SH-SY5Y cells significantly decreased Lrp2 expression, resulting in a reduction of Akt activation and induction of proapoptotic caspase-3, thereby increasing cell apoptosis."
genetics_overexpression_promote	hsa-mir-182	Cerebral Ischemia	27242323	miR-182 plays an aggressive role in the cerebral ischemia injury
genetics_overexpression_promote	hsa-mir-34a	Osteoarthritis	27247228	Overexpression of miR-34a promoted apoptosis and inhibited cell proliferation in human chondrocytes
genetics_overexpression_promote	hsa-mir-1908	Wound Healing	27256397	miR-1908 had a positive role in scar formation
genetics_overexpression_promote	hsa-mir-1301	Prostate Neoplasms	27261573	miR-1301 promoted cell proliferation of prostate cancer.
genetics_overexpression_promote	hsa-mir-205	Colorectal Carcinoma	27271572	miR-205 and miR-373 may differentially contribute to the aggressive phenotype of MAC in CRC.
genetics_overexpression_promote	hsa-mir-373	Colorectal Carcinoma	27271572	miR-205 and miR-373 may differentially contribute to the aggressive phenotype of MAC in CRC.
genetics_overexpression_promote	hsa-mir-206	Alzheimer Disease	27277332	miR�06 upregulation enhanced LPS‑induced inflammation and Aβ release in microglia
genetics_overexpression_promote	hsa-mir-21	Neuroblastoma	27285119	"Forced overexpression of miR-21 significantly increased NB cell proliferation, migration, and invasion."
genetics_overexpression_promote	hsa-mir-18a	"Squamous Cell Carcinoma, Esophageal"	27291152	upregulation of miR-18a promoted cell proliferation by increasing cylin D1
genetics_overexpression_promote	hsa-mir-429	Diabetes Mellitus	27299781	"increased miR-429 could down-regulate the expression of Ocln by targeting the Ocln 3'-UTR, which impaired intestinal barrier function in DM mice."
genetics_overexpression_promote	hsa-mir-9	Influenza	27322373	Overexpression of miR-9 enhanced viral gene expression and production of infectious progeny
genetics_overexpression_promote	hsa-mir-222	Gastric Neoplasms	27323780	"Gastrin-induced miR-222 overexpression resulted in reduced expression and cytoplasmic mislocalisation of p27kip1, which in turn caused actin remodelling and increased migration in AGSGR cells."
genetics_overexpression_promote	hsa-mir-19a	Glioma	27329239	Overexpression of miR-19a by a miR-19a mimic promoted glioma cell proliferation and invasion.
genetics_overexpression_promote	hsa-mir-548a	"Carcinoma, Hepatocellular"	27340352	"overexpression of miR-548a-5p in HCC cell lines promoted cell proliferation, increased colony forming ability and hampered cell apoptosis."
genetics_overexpression_promote	hsa-mir-29a	Atrial Fibrillation	27341015	miR-29a-3p transfection in cardiomyocytes produced the effects on the ICa
genetics_overexpression_promote	hsa-mir-301b	Lung Neoplasms	27352910	"ectopic expression of miR-301b enhanced cell population growth, reduced apoptosis and reduced sensitivity of cells to chemotherapy."
genetics_overexpression_promote	hsa-mir-20a	Uveal Melanoma	27356499	"miR�0a mimics were transfected into UM cells, which led to increases in cell growth, migration and invasion activities."
genetics_overexpression_promote	hsa-mir-92a	"Carcinoma, Nasopharyngeal"	27366095	miR-92a overexpression potentiated the migration and invasion of 6-10B cells
genetics_overexpression_promote	hsa-mir-340	Gastric Neoplasms	27374211	"Functionally, forced expression of miR-340 promoted cell viability, proliferation, colony formation and cell cycle progression in the SGC-7901 cells"
genetics_overexpression_promote	hsa-mir-21	Cholesteatoma	27376830	miR-21 promotes the proliferation and invasion of cholesteatoma keratinocytes.
genetics_overexpression_promote	hsa-mir-488	Osteosarcoma	27376839	"We also found that exogenous over-expression of microRNA-488 promotes the proliferation, reduces the apoptosis and decreases the sensitivity to chemotherapy (doxorubicin) of osteosarcoma cells"
genetics_overexpression_promote	hsa-mir-205	Myelodysplastic Syndromes	27379838	Our findings suggest that miR-205-5p upregulation contributes to MDS by suppressing PTEN and that miR-205-5p thus acts as an oncogene in hematopoietic cells.
genetics_overexpression_promote	hsa-mir-181b	Gastric Neoplasms	27383203	Overexpression of miR-181b mimic induced an in vitro EMT-like change to a phenotype similar to that following TGF-β treatment alone and was reversed by miRNA-181b inhibitor.
genetics_overexpression_promote	hsa-mir-27a	Gastric Neoplasms	27409164	"And overexpression of miR-27a-3p, but not miR-27a-5p, markedly promoted gastric cancer cell proliferation in vitro as well as tumor growth in vivo."
genetics_overexpression_promote	hsa-mir-92a	Acute Myocardial Infarction	27411964	"Further, it could be observed in cellular experiments that treatment of miR-92a mimics can further upregulate endothelial injury markers."
genetics_overexpression_promote	hsa-mir-92b	Bladder Neoplasms	27430302	"In this study, we demonstrated that miR-92b could uniquely promote cell migration and invasion of BCa cells, but had no effect on cell proliferation."
genetics_overexpression_promote	hsa-mir-1303	Neuroblastoma	27434867	"miR-1303 overexpression promoted the proliferation of SH-SY5Y NB cell investigated by MTT assay, colony formation assay and anchorage-independent growth ability assay, while miR-1303 knockdown reduced this effect."
genetics_overexpression_promote	hsa-mir-146a	Cerebral Ischemia	27449900	"In conclusion, our study revealed that miR-146a contributes to OGD/R injury in vitro."
genetics_overexpression_promote	hsa-mir-940	"Carcinoma, Pancreatic"	27459115	Over-expression of microRNA-940 promotes cell proliferation by targeting GSK3β and sFRP1 in human pancreatic carcinoma.
genetics_overexpression_promote	hsa-mir-181a	Atherosclerosis	27460740	The exogenous overexpression of miR-181a accelerates the apoptosis rates of HUVECs in response to H2O2.
genetics_overexpression_promote	hsa-mir-769	Melanoma	27470346	"Overexpression of miR-769 promoted cell proliferation in human melanoma cell line A375, whereas miR-769-in reverses the function."
genetics_overexpression_promote	hsa-mir-183	"Carcinoma, Breast"	27476679	Overexpression of miR-183-5p significantly enhanced the cell proliferation and inhibited cell apoptosis in MCF-7 and MDA-MB-231 cells.
genetics_overexpression_promote	hsa-mir-194	"Carcinoma, Ovarian"	27486333	"Overexpression of miR-194 in ovarian cancer cells promotes cell proliferation, migration, and invasion; in contrast, inhibition of the expression of miR-194 has the opposite effects."
genetics_overexpression_promote	hsa-mir-195	Myocardial Ischemic-Reperfusion Injury	27489501	Up-regulation of miR-195 in ischemic cardiomyocytes promotes ischemic apoptosis by targeting Bcl-2.
genetics_overexpression_promote	hsa-mir-363	Glioma	27495233	"Transfection of miR-363 induced cell survival, while inhibition of miR-363 significantly reduced glioma cell viability."
genetics_overexpression_promote	hsa-mir-200c	"Carcinoma, Gastric"	27498672	"Finally, ectopic expression of miR-200c or knockdown of DNMT3a expression impeded GC cell growth, migration and invasion."
genetics_overexpression_promote	hsa-mir-15b	"Carcinoma, Hepatocellular"	27499071	"It was observed that high expression of miR-15b promoted cell proliferation of the HCC cells, while low expression of miR-15b suppressed cell growth and induced the apoptosis of HepG2 cells."
genetics_overexpression_promote	hsa-mir-17	Macular Degeneration	27505139	Transfection of miR-17-3p mimic in ARPE-19 induced cell death and exacerbated oxidative lethality that was alleviated by miR-17-3p inhibitor.
genetics_overexpression_promote	hsa-mir-19b	Lung Fibrosis	27508324	"Overexpression of miR-19b in small-airway epithelial cells promoted the mechanical stretch-induced EMT phenotypes, whereas inhibition of miR-19b attenuated it."
genetics_overexpression_promote	hsa-mir-1	"Carcinoma, Colon"	27511117	overexpression of PIK3CA-premir1 in HCT116 and SW480 cells resulted in significant reduction of the sub-G1 cell distribution and apoptotic cell rate and resulted in increased cell proliferation.
genetics_overexpression_promote	hsa-mir-483	"Carcinoma, Gastric"	27511210	overexpression of miR�83�p by transfection with miR�83�p mimics significantly increased cell proliferation and Annexin V‑propidium iodide staining indicated the suppression of cell apoptosis.
genetics_overexpression_promote	hsa-mir-125b	Retinoblastoma	27518550	overexpression of miR-125b apparently promotes RB cell proliferation and migration in vitro.
genetics_overexpression_promote	hsa-mir-31	"Squamous Cell Carcinoma, Head and Neck"	27528032	miR-31 associated oncogenicities were rescued by ARID1A expression in HNSCC cells.
genetics_overexpression_promote	hsa-mir-15b	Neoplasms [unspecific]	27530410	increased miR-15b and decreased RECK expression may contribute to the pathobiology of LYO.
genetics_overexpression_promote	hsa-mir-15b	Uterine Leiomyoma	27530410	"Our findings suggest that miR-15b negatively regulates RECK expression in LYO, and increased miR-15b and decreased RECK expression may contribute to the pathobiology of LYO."
genetics_overexpression_promote	hsa-mir-375	Liver Failure	27531059	"Thus miR-375 is identified as a novel repressor of UGT1A-mediated hepatic acetaminophen glucuronidation through reduced AhR expression, which could predispose some individuals to increased risk for acetaminophen-induced ALF"
genetics_overexpression_promote	hsa-mir-181a	"Leukemia, Myeloid, Acute"	27531761	Overexpression of miR-181a can promote AML cell proliferation.
genetics_overexpression_promote	hsa-mir-29b	Hearing Loss	27635430	miR-29b overexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC-1¦Á signaling: Implications for age-related hearing loss.
genetics_overexpression_promote	hsa-mir-1288	"Squamous Cell Carcinoma, Esophageal"	27658568	Overexpression of miR-1288 play a key role in thepathogenesis of ESCCs and its modulation may have potential therapeutic value in patients with ESCC
genetics_overexpression_promote	hsa-mir-9	Osteosarcoma	27724924	MiR-9 is overexpressed in spontaneous canine osteosarcoma and promotes a metastatic phenotype including invasion and migration in osteoblasts and osteosarcoma cell lines.
genetics_overexpression_promote	hsa-mir-760	"Carcinoma, Ovarian"	27726922	MiR-760 overexpression promotes proliferation in ovarian cancer by downregulation of PHLPP2 expression.
genetics_overexpression_promote	hsa-mir-182	"Squamous Cell Carcinoma, Head and Neck"	27744260	Overexpression of TP53 mutation-associated microRNA-182 promotes tumor cell proliferation and migration in head and neck squamous cell carcinoma.
genetics_overexpression_promote	hsa-mir-138	Obesity	27762728	miR-138/miR-222 Overexpression Characterizes the miRNome of Amniotic Mesenchymal Stem Cells in Obesity.
genetics_overexpression_promote	hsa-mir-222	Obesity	27762728	miR-138/miR-222 Overexpression Characterizes the miRNome of Amniotic Mesenchymal Stem Cells in Obesity.
genetics_overexpression_promote	hsa-mir-212	"Adenocarcinoma, Pancreatic Ductal"	27814273	Overexpressions of miR-212 are associated with poor prognosis of patients with pancreatic ductal adenocarcinoma.
genetics_overexpression_promote	hsa-mir-21	Choriocarcinoma	27922982	"miR-21 Is Overexpressed in Hydatidiform Mole Tissues and Promotes Proliferation, Migration, and Invasion in Choriocarcinoma Cells."
genetics_overexpression_promote	hsa-mir-675	"Squamous Cell Carcinoma, Head and Neck"	27994496	Overexpression of lncRNA H19/miR-675 promotes tumorigenesis in head and neck squamous cell carcinoma.
genetics_overexpression_promote	hsa-mir-375	Diabetes Mellitus	28017506	Insulin producing cells generation by overexpression of miR-375 in adipose-derived mesenchymal stem cells from diabetic patients.
genetics_overexpression_promote	hsa-mir-223	Glioblastoma	28035389	"overexpression of miR-223 increases TMZ chemoresistance, while inhibition of miR-223 with antagomir markedly decreases TMZ chemoresistance in GBM cells"
genetics_overexpression_promote	hsa-mir-92a	Osteosarcoma	28069547	Overexpression of miR-92a promotes the tumor growth of osteosarcoma by suppressing F-box and WD repeat-containing protein 7.
genetics_overexpression_promote	hsa-mir-205	Endometrial Neoplasms	28105153	Overexpression of microRNA-205 predicts lymph node metastasis and indicates an unfavorable prognosis in endometrial cancer.
genetics_overexpression_promote	hsa-mir-196b	Myelodysplastic Syndromes	28224273	Over-expression of miR-196b-5p is significantly associated with the progression of myelodysplastic syndrome.
genetics_overexpression_promote	hsa-mir-214	Osteosarcoma	28260089	Overexpression of miR?214 promotes the progression of human osteosarcoma by regulating the Wnt/¦Â?catenin signaling pathway.
genetics_overexpression_promote	hsa-mir-320	Ovarian Neoplasms	28338235	Overexpression of Hsa-miR-320 Is Associated With Invasion and Metastasis of Ovarian Cancer.
genetics_overexpression_promote	hsa-mir-10b	Colorectal Carcinoma	28345456	Overexpression of miR-10b in colorectal cancer patients: Correlation with TWIST-1 and E-cadherin expression.
genetics_overexpression_promote	hsa-mir-221	Ovarian Neoplasms	28350128	Overexpression of miRNA-221 promotes cell proliferation by targeting the apoptotic protease activating factor-1 and indicates a poor prognosis in ovarian cancer.
genetics_overexpression_promote	hsa-mir-196b	"Carcinoma, Ovarian"	28387653	Overexpression of microRNA-196b Accelerates Invasiveness of Cancer Cells in Recurrent Epithelial Ovarian Cancer Through Regulation of Homeobox A9.
genetics_overexpression_promote	hsa-mir-1	Myocardial Infarction	28397788	Over-expression of microRNA-1 causes arrhythmia by disturbing intracellular trafficking system.
genetics_overexpression_promote	hsa-mir-34a	Colorectal Adenocarcinoma	28624481	"miR-34a overexpression predicts poor prognostic outcome in colorectal adenocarcinoma, independently of clinicopathological factors with established prognostic value."
genetics_overexpression_promote	hsa-let-7	"Carcinoma, Hepatocellular"	28796071	Overexpression of microRNA let-7 correlates with disease progression and poor prognosis in hepatocellular carcinoma
genetics_overexpression_promote	hsa-let-7a	"Carcinoma, Hepatocellular"	28796071	Overexpression of microRNA let-7 correlates with disease progression and poor prognosis in hepatocellular carcinoma
genetics_overexpression_promote	hsa-let-7e	"Carcinoma, Hepatocellular"	28796071	Overexpression of microRNA let-7 correlates with disease progression and poor prognosis in hepatocellular carcinoma
genetics_overexpression_promote	hsa-mir-194	Colorectal Carcinoma	29109785	Overexpression of miR-194 Reverses HMGA2-driven Signatures in Colorectal Cancer.
genetics_overexpression_promote	hsa-mir-10b	Neoplasms [unspecific]	29262659	"the overexpression of miR-10b was significantly correlated with metastasis status, and indicated the potential clinical use of miR-10b as a molecular biomarker, particularly in assessing prognosis for patients with cancers"
genetics_overexpression_promote	hsa-mir-130a	"Leukemia, Myeloid, Acute"	29493383	MiR-130a is aberrantly overexpressed in adult acute myeloid leukemia with t(8;21) and its suppression induces AML cell death.
genetics_overexpression_promote	hsa-mir-155	"Leukemia, Myeloid, Acute"	29657293	miR-155 overexpression plays a key pathogenic role in some lymphomas and acute myeloid leukemias has led to the development of an antagomir-based approach as a new promising therapeutic strategy
genetics_overexpression_promote	hsa-mir-19a	Multiple Myeloma	29665917	"miR-19a is overexpressed significantly in Lp-1 and U266 multiple myeloma cells, and promots the proliferation and invasion of the myeloma cells, but inhibits their apoptosis"
genetics_overexpression_promote	hsa-mir-34a	Pituitary Adenoma	30109259	Overexpression of microRNA-34a Attenuates Proliferation and Induces Apoptosis in Pituitary Adenoma Cells via SOX7.
genetics_overexpression_promote	hsa-mir-221	"Carcinoma, Breast"	30110679	Our findings provide strong evidence that miR-9 and miR-221 can enhance the generation of cancer stem cells to yield an invasive phenotype and that overexpression of these miRNAs predicts a poor outcome for breast cancer patients
genetics_overexpression_promote	hsa-mir-9	"Carcinoma, Breast"	30110679	Our findings provide strong evidence that miR-9 and miR-221 can enhance the generation of cancer stem cells to yield an invasive phenotype and that overexpression of these miRNAs predicts a poor outcome for breast cancer patients
genetics_overexpression_promote	hsa-mir-214	Myeloma	30357841	"Bone marrow fibroblasts overexpress miR-27b and miR-214 in step with multiple myeloma progression, dependent on tumour cell-derived exosomes."
genetics_overexpression_promote	hsa-mir-27b	Myeloma	30357841	"Bone marrow fibroblasts overexpress miR-27b and miR-214 in step with multiple myeloma progression, dependent on tumour cell-derived exosomes."
genetics_overexpression_promote	hsa-mir-301a	Colorectal Carcinoma	30362160	Overexpression of miR-301a-3p promotes colorectal cancer cell proliferation and metastasis by targeting deleted in liver cancer-1 and runt-related transcription factor 3.
genetics_overexpression_promote	hsa-mir-361	"Adenocarcinoma, Lung"	30365047	Overexpression of miR?361?5p plays an oncogenic role in human lung adenocarcinoma through the regulation of SMAD2.
genetics_overexpression_suppress	hsa-mir-125b-1	"Carcinoma, Hepatocellular"	18649363	miR-125b: overexpression of miR-125b in HCC cell line could obviously suppress the cell growth and phosporylation of Akt
genetics_overexpression_suppress	hsa-mir-125b-2	"Carcinoma, Hepatocellular"	18649363	miR-125b: overexpression of miR-125b in HCC cell line could obviously suppress the cell growth and phosporylation of Akt
genetics_overexpression_suppress	hsa-mir-142	Lung Neoplasms	19228723	"miR-142-5p: were repressed, overexpression can inhibitu lung cancer growth"
genetics_overexpression_suppress	hsa-mir-145	Lung Neoplasms	19228723	"miR-145: were repressed, overexpression can inhibitu lung cancer growth"
genetics_overexpression_suppress	hsa-mir-34c	Lung Neoplasms	19228723	"miR-34c: were repressed, overexpression can inhibitu lung cancer growth"
genetics_overexpression_suppress	hsa-mir-100	Ovarian Neoplasms	20081105	"Overexpression of mir-100 inhibited mTOR signaling and enhanced sensitivity to the rapamycin analog RAD001 (everolimus), confirming the key relationship between mir-100 and the mTOR pathway."
genetics_overexpression_suppress	hsa-mir-22	Ovarian Neoplasms	20081105	"overexpression of the putative tumor suppressor mir-22 repressed the EVI1 oncogene, which is known to suppress apoptosis by stimulating phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog 1 signaling."
genetics_overexpression_suppress	hsa-mir-194	Liver Neoplasms	20979124	The overexpression of miR-194 in liver mesenchymal-like cancer cells reduced the expression of the mesenchymal cell marker N-cadherin and suppressed invasion and migration of the mesenchymal-like cancer cells both in vitro and in vivo
genetics_overexpression_suppress	hsa-let-7a-1	Hypertrophy	21183740	Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7.
genetics_overexpression_suppress	hsa-let-7a-2	Hypertrophy	21183740	Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7.
genetics_overexpression_suppress	hsa-let-7a-3	Hypertrophy	21183740	Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7.
genetics_overexpression_suppress	hsa-let-7b	Hypertrophy	21183740	Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7.
genetics_overexpression_suppress	hsa-let-7c	Hypertrophy	21183740	Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7.
genetics_overexpression_suppress	hsa-let-7d	Hypertrophy	21183740	Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7.
genetics_overexpression_suppress	hsa-let-7e	Hypertrophy	21183740	Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7.
genetics_overexpression_suppress	hsa-let-7f-1	Hypertrophy	21183740	Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7.
genetics_overexpression_suppress	hsa-let-7f-2	Hypertrophy	21183740	Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7.
genetics_overexpression_suppress	hsa-let-7g	Hypertrophy	21183740	Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7.
genetics_overexpression_suppress	hsa-let-7i	Hypertrophy	21183740	Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7.
genetics_overexpression_suppress	hsa-mir-98	Hypertrophy	21183740	Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7.
genetics_overexpression_suppress	hsa-mir-146a	Atherosclerosis	21329689	Over-expression of miR-146a may be useful in the prevention and treatment of atherosclerosis.
genetics_overexpression_suppress	hsa-mir-128	Glioblastoma	21358821	"Our analysis predicted a significant association between miR-128 and the protein kinase WEE1, which we subsequently validated experimentally by showing that the over-expression of the naturally under-expressed miR-128 in glioma cells resulted in the inhibition of WEE1 in glioblastoma cells."
genetics_overexpression_suppress	hsa-mir-663	Leukemia	21518471	"miRNA-663 in K562 cells is up-regulated after 5-aza treatment. Over-expression of miR-663 can suppress the proliferation of K562 cells, which suggests that miR-663 may possesses suppressive effect for leukaemia."
genetics_overexpression_suppress	hsa-mir-146b	Lung Neoplasms	21789255	Overexpression of the Lung Cancer-Prognostic miR-146b MicroRNAs Has a Minimal and Negative Effect on the Malignant Phenotype of A549 Lung Cancer Cells.
genetics_overexpression_suppress	hsa-mir-199a-1	"Carcinoma, Hepatocellular"	21847633	Lentivirus-Mediated Overexpression of MicroRNA-199a Inhibits Cell Proliferation of Human Hepatocellular Carcinoma.
genetics_overexpression_suppress	hsa-mir-199a-2	"Carcinoma, Hepatocellular"	21847633	Lentivirus-Mediated Overexpression of MicroRNA-199a Inhibits Cell Proliferation of Human Hepatocellular Carcinoma.
genetics_overexpression_suppress	hsa-mir-16	Acute Lung Injury	22185353	"Accordingly, over-expression of miR-16 could significantly suppress the luciferase activity of reporter fusion with the binding sites of TNF¦Á in its 3'UTR region, suggesting that miR-16 played its role in LPS-induced lung inflammation by a direct manner."
genetics_overexpression_suppress	hsa-mir-10a	"Leukemia, Myeloid, Acute"	22348345	miR-10a is aberrantly overexpressed in Nucleophosmin1 mutated Acute Myeloid Leukaemia and its suppression induces cell death.
genetics_overexpression_suppress	hsa-mir-143	Colon Neoplasms	22362069	"Overexpression of three miRNA (miR200c*, miR143*, and miR424*) significantly abrogated invasive potential."
genetics_overexpression_suppress	hsa-mir-200c	Colon Neoplasms	22362069	"Overexpression of three miRNA (miR200c*, miR143*, and miR424*) significantly abrogated invasive potential."
genetics_overexpression_suppress	hsa-mir-424	Colon Neoplasms	22362069	"Overexpression of three miRNA (miR200c*, miR143*, and miR424*) significantly abrogated invasive potential."
genetics_overexpression_suppress	hsa-let-7a-1	Esophageal Neoplasms	22363450	"Curcumin treatment down-regulate the expressions of Notch-1 specific microRNAs miR-21 and miR-34a, and upregulated tumor suppressor let-7a miRNA."
genetics_overexpression_suppress	hsa-let-7a-2	Esophageal Neoplasms	22363450	"Curcumin treatment down-regulate the expressions of Notch-1 specific microRNAs miR-21 and miR-34a, and upregulated tumor suppressor let-7a miRNA."
genetics_overexpression_suppress	hsa-let-7a-3	Esophageal Neoplasms	22363450	"Curcumin treatment down-regulate the expressions of Notch-1 specific microRNAs miR-21 and miR-34a, and upregulated tumor suppressor let-7a miRNA."
genetics_overexpression_suppress	hsa-mir-29a	Ovarian Neoplasms	22479643	over-expression of miR-29a in vitro repressed several anti-correlated genes (including DNMT3A and DNMT3B) and substantially decreased ovarian cancer cell viability.
genetics_overexpression_suppress	hsa-let-7a-1	Colorectal Carcinoma	22584434	High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease.
genetics_overexpression_suppress	hsa-let-7a-2	Colorectal Carcinoma	22584434	High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease.
genetics_overexpression_suppress	hsa-let-7a-3	Colorectal Carcinoma	22584434	High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease.
genetics_overexpression_suppress	hsa-mir-92a-1	"Carcinoma, Hepatocellular"	22587342	Oxidative DNA damage correlates with cell immortalization and mir-92 expression in hepatocellular carcinoma.
genetics_overexpression_suppress	hsa-mir-34b	"Carcinoma, Lung, Non-Small-Cell"	22593438	Overexpression of miR-34b significantly reduced cell survival at lower than 4 Gy radiation doses.
genetics_overexpression_suppress	hsa-mir-223	Rheumatoid Arthritis	22903258	Overexpression of microRNA-223 in rheumatoid arthritis synovium controls osteoclast differentiation.
genetics_overexpression_suppress	hsa-let-7b	"Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic"	22918121	The enforced expression of let-7b in ALL cell lines with an MLL fusion gene inhibited their growth.
genetics_overexpression_suppress	hsa-mir-34a	Melanoma	22969970	"These results suggest that overexpression of miR-34a and c suppresses invasive and generative potentials, respectively, in human malignant melanoma."
genetics_overexpression_suppress	hsa-mir-34c	Melanoma	22969970	"All four melanoma cell lines showed significant expression of miR-34s - A375: miR-34a 0.6176, miR-34b 0.7625, miR-34c 0.7877; "
genetics_overexpression_suppress	hsa-mir-124	Medulloblastoma	23172372	"MiR-124 overexpression inhibits the proliferation of medulloblastoma cells, and this effect is mediated mostly through the action of miR-124 upon CDK6."
genetics_overexpression_suppress	hsa-mir-142	Gastric Neoplasms	23209550	Overexpression of miR-142-5p and miR-155 in Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Resistant to Helicobacter pylori Eradication
genetics_overexpression_suppress	hsa-mir-155	Gastric Neoplasms	23209550	Overexpression of miR-142-5p and miR-155 in Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Resistant to Helicobacter pylori Eradication
genetics_overexpression_suppress	hsa-mir-19b	Cardiovascular Diseases [unspecific]	23443808	"Overexpression of miR-19b inhibited activation of the Wnt/¦Â-catenin signaling pathway in P19 cells, which may regulate cardiomyocyte differentiation."
genetics_overexpression_suppress	hsa-mir-133a	Hypertension	23460283	"In vitro overexpression of miR-27a,-29a, and -133a inhibited cardiomyocyte hypertrophy and reduced collagen expression. "
genetics_overexpression_suppress	hsa-mir-27a	Hypertension	23460283	"In vitro overexpression of miR-27a,-29a, and -133a inhibited cardiomyocyte hypertrophy and reduced collagen expression. "
genetics_overexpression_suppress	hsa-mir-29a	Hypertension	23460283	"In vitro overexpression of miR-27a,-29a, and -133a inhibited cardiomyocyte hypertrophy and reduced collagen expression. "
genetics_overexpression_suppress	hsa-mir-155	Ovarian Neoplasms	23523916	overexpression of miR-155 may prevent tumorigenesis in human ovarian cancer through downregulation of CLDN1.
genetics_overexpression_suppress	hsa-mir-138-1	Neuroblastoma	23562653	miR-138 Overexpression is more powerful than hTERT knockdown to potentiate apigenin for apoptosis in neuroblastoma in vitro and in vivo
genetics_overexpression_suppress	hsa-mir-138-2	Neuroblastoma	23562653	miR-138 Overexpression is more powerful than hTERT knockdown to potentiate apigenin for apoptosis in neuroblastoma in vitro and in vivo
genetics_overexpression_suppress	hsa-mir-34a	Gastric Neoplasms	24068565	"miR-34a over-expression could improve the sensitivity of gastric cancer cells against cisplatin-based chemotherapies, with PI3K/AKT/survivin signaling pathway possibly involved in the mechanism."
genetics_overexpression_suppress	hsa-mir-181b	Atherosclerosis	24084690	overexpression of miR-181b in the aortic intima of apolipoprotein E-deficient mice and suppressed NF-¦ÊB signaling revealed by bioluminescence imaging and reduced target gene expression in the aortic arch in apolipoprotein E-deficient/NF-¦ÊB-luciferase transgenic mice.
genetics_overexpression_suppress	hsa-mir-129	Medulloblastoma	24093088	Overexpression of miR-129-5p using mimics decreased DAOY proliferation
genetics_overexpression_suppress	hsa-let-7a	Neoplasms [unspecific]	24100239	Human Argonaute-3 specifically enhances the passenger strand expression and activity of the tumor suppressor microRNA let-7a.
genetics_overexpression_suppress	hsa-mir-486	Breast Neoplasms	24104550	"in vitro functional screening of the downregulated miRNAs in non-malignant and breast cancer cell lines identified several possible tumor suppressor miRNAs, including miR-193b, miR-193a-3p, miR-126, miR-134, miR-132, miR-486-5p, miR-886-3p, miR-195 and miR-497, showing reduced growth when re-expressed in cancer cells"
genetics_overexpression_suppress	hsa-let-7a	"Diabetes Mellitus, Type 2"	24105413	"Expression of microRNA let-7a and let-7d, which are direct translational repressors of the IL-13 gene, was increased in skeletal muscle from T2DM patients. "
genetics_overexpression_suppress	hsa-mir-200c	Melanoma	24120113	Overexpression of microRna-200c in CD44+CD133+ CSCS inhibits the cellular migratory and invasion as well as tumorigenicity in mice.
genetics_overexpression_suppress	hsa-mir-145	Melanoma	24248543	Overexpression of miR-145 increases the sensitivity of vemurafenib in drug-resistant colo205 cell line.
genetics_overexpression_suppress	hsa-mir-449a	"Adenocarcinoma, Gastric"	24260067	The overexpression of miR-449a inhibited gastric adenocarcinoma cell growth and promoted cell apoptosis in the MGC-803 and SGC-7901 gastric adenocarcinoma cell lines.
genetics_overexpression_suppress	hsa-let-7a	Ewing Sarcoma	24383407	"Restored let-7a expression inhibited cell proliferation, migration, as well as invasion; arrested cell cycle progression; and induced cell apoptosis of both cell lines."
genetics_overexpression_suppress	hsa-mir-133b	Gastric Neoplasms	24443799	MiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells.
genetics_overexpression_suppress	hsa-mir-24	Heart Failure	24454859	"In vivo delivery of miR-24 into a mouse MI model suppressed cardiac cell death, attenuated infarct size, and rescued cardiac dysfunction."
genetics_overexpression_suppress	hsa-mir-34a	"Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal"	24482044	Ectopic expression of miR-34a and miR-34c in Hep-2 cells significantly induced the cell proliferation and migration ability in vitro.
genetics_overexpression_suppress	hsa-mir-34c	"Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal"	24482044	Ectopic expression of miR-34a and miR-34c in Hep-2 cells significantly induced the cell proliferation and migration ability in vitro.
genetics_overexpression_suppress	hsa-mir-107	Breast Neoplasms	24482686	"Overexpression of miR-107 suppressed MDA-MB-231 cell proliferation and migration, meanwhile the cells were arrested at G0/G1 phase."
genetics_overexpression_suppress	hsa-mir-7	Liver Neoplasms	24491049	"Over-expression of miR-7 could significantly inhibit the growth of human lung cancer cells in vivo and in vitro, which might be related to the down-regulated expression of tumor growth-associated protein CGGBP1."
genetics_overexpression_suppress	hsa-mir-21	Atherosclerosis	24502419	"Further analysis confirmed that overexpression of miR-21 by transfection with miR-21 mimics notably attenuated lipid accumulation and lipid-laden foam cell formation in LPS-stimulated macrophages, which was reversely up-regulated when silencing miR-21 expression via anti-miR-21 inhibitor transfection, indicating a reverse regulator of miR-21 in LPS-induced foam cell formation."
genetics_overexpression_suppress	hsa-let-7c	Ovarian Neoplasms	24507678	"After application of let-7c, number of T29A2+ cell clones was decreased significantly, however, after the application of Anti-let-7, the number of clones restored, and there was no significant difference compared with the negative control group."
genetics_overexpression_suppress	hsa-mir-29a	Diabetes Mellitus	24578127	"Diabetic miR-29a transgenic mice had better nephrin levels, podocyte viability, and renal function and less glomerular fibrosis and inflammation reaction compared with diabetic wild-type mice."
genetics_overexpression_suppress	hsa-mir-206	Ovarian Neoplasms	24604205	microRNA-206 overexpression inhibits cellular proliferation and invasion of estrogen receptor ¦Á-positive ovarian cancer cells.
genetics_overexpression_suppress	hsa-mir-183	Neuropathic Pain	24612023	"Intrathecal administration of lentivirions expressing miR-183 downregulated SNL-induced increases in the expression of Nav1.3 and brain-derived neurotrophic factor (BDNF), which correlated with the significant attenuation of SNL-induced mechanical allodynia."
genetics_overexpression_suppress	hsa-mir-143	Leukemia	24626955	Overexpression of microRNA-143 inhibits growth and induces apoptosis in human leukemia cells.
genetics_overexpression_suppress	hsa-mir-499	Heart Failure	24646523	"We report that cardiac-abundant miR-499 could protect neonatal rat cardiomyocytes against H 2O 2-induced apoptosis. Increased miR-499 level favored survival, while decreased miR-499 level favored apoptosis."
genetics_overexpression_suppress	hsa-mir-499	Myocardial Infarction	24646523	"We report that cardiac-abundant miR-499 could protect neonatal rat cardiomyocytes against H 2O 2-induced apoptosis. Increased miR-499 level favored survival, while decreased miR-499 level favored apoptosis."
genetics_overexpression_suppress	hsa-mir-155	Glioblastoma	24705102	"Over-expression of miR-136 and miR-634 miRNAs negatively affected proliferation, but not migration, while expression of miR-155 reduced migration but did not affect the proliferation of LN229 cells."
genetics_overexpression_suppress	hsa-mir-155	Arthritis	24708712	Overexpression of miR-155 in the gouty SFMC leads to suppress SHIP-1 levels and enhance proinflammatory cytokines.
genetics_overexpression_suppress	hsa-mir-34a	"Carcinoma, Renal Cell"	24765202	"The Cell Counting Kit-8 identified that transient forced expression of miR-34a inhibited cell growth and resulted in cell cycle arrest, which was evaluated by flow cytometry."
genetics_overexpression_suppress	hsa-mir-206	"Carcinoma, Hepatocellular"	24919811	"MicroRNA-206 overexpression promotes apoptosis, induces cell cycle arrest and inhibits the migration of human hepatocellular carcinoma HepG2 cells."
genetics_overexpression_suppress	hsa-mir-99a	Bladder Neoplasms	24944696	"It was found that miRNA-99a inhibits cell proliferation, migration and invasion in T24 and EJ cells."
genetics_overexpression_suppress	hsa-mir-34a	Glioma	24944883	"Ectopic expression of miR-34a in glioma stem cell-lines HNGC-2 and NSG-K16 decreased the proliferative and migratory potential of these cells, induced cell cycle arrest and caused apoptosis."
genetics_overexpression_suppress	hsa-mir-146a	Ischemia-Reperfusion Injury	24987958	"Overexpression of miR-146a directly decreased IRAK1 and TRAF6 expression and attenuated the release of proinflammatory cytokines through the inactivation of NF-κB P65 in hypoxia/reoxygenation (H/R)-induced macrophages, RAW264.7 cells."
genetics_overexpression_suppress	hsa-let-7	Pancreatic Neoplasms	25017900	"Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition."
genetics_overexpression_suppress	hsa-mir-7	Neurodegenerative Diseases [unspecific]	25071443	"Overexpression of miR-7 or miR-153 by adenoviral transduction protected cortical neurons from MPP(+)-induced toxicity, restored neuronal viability and anti-apoptotic BCL-2 protein levels while attenuated activation of caspase-3."
genetics_overexpression_suppress	hsa-mir-155	Cerebral Malaria	25189739	AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated malarial parasites.
genetics_overexpression_suppress	hsa-let-7d	"Carcinoma, Renal Cell"	25193015	"Functional studies indicated that ectopic expression of let-7d significantly inhibited RCC cell proliferation, migration, and peripheral blood monocyte (PBMC) recruitment in vitro, as well as tumor growth, metastasis, and tumor macrophage infiltration in vivo."
genetics_overexpression_suppress	hsa-let-7g	Osteosarcoma	25197332	"Functional investigation revealed both restoration of let-7g and silencing Aurora-B induce cell apoptosis and suppressed cell viability, migratory and invasive ability in OS cells."
genetics_overexpression_suppress	hsa-mir-449a	"Carcinoma, Gastric"	25202363	The level of MGC-803 cell proliferation was decreased and the apoptosis level was increased by the upregulation of miR-449a expression
genetics_overexpression_suppress	hsa-mir-200b	Hypertrophic Scar	25228082	Overexpression of miR-200b inhibits the cell proliferation and promotes apoptosis of human hypertrophic scar fibroblasts in vitro.
genetics_overexpression_suppress	hsa-mir-206	"Squamous Cell Carcinoma, Oral"	25246801	"upregulation of miR-206 in Tca8113 cells was able to reduce cell proliferation, invasion, and migration and promote cell apoptosis in vitro."
genetics_overexpression_suppress	hsa-mir-200c	Lung Neoplasms	25277203	miR-200c overexpression is associated with better efficacy of EGFR-TKIs in non-small cell lung cancer patients with EGFR wild-type.
genetics_overexpression_suppress	hsa-mir-21	Ischemia-Reperfusion Injury	25322693	miR-21 is endowed with anti-apoptotic properties by suppressing the expression of PDCD4 gene and active caspase 3/8 fragments in the condition of renal IRI.
genetics_overexpression_suppress	hsa-mir-7	Lung Neoplasms	25334070	"Restoration of miR-7 inhibited 3LL cell proliferation, induced cell apoptosis in vitro and reduced tumorigenicity in vivo."
genetics_overexpression_suppress	hsa-mir-30b	"Carcinoma, Laryngeal"	25356506	Overexpression of microRNA-30b improves adenovirus-mediated p53 cancer gene therapy for laryngeal carcinoma.
genetics_overexpression_suppress	hsa-mir-218	"Carcinoma, Hepatocellular"	25374061	Overexpression of miR-218 inhibits hepatocellular carcinoma cell growth through RET.
genetics_overexpression_suppress	hsa-let-7g	"Carcinoma, Hepatocellular"	25435961	"the overexpression of let-7g/i significantly suppressed DNA replication, inhibited cell proliferation and promoted apoptosis of BEL-7402 hepatoma cells."
genetics_overexpression_suppress	hsa-let-7i	"Carcinoma, Hepatocellular"	25435961	"the overexpression of let-7g/i significantly suppressed DNA replication, inhibited cell proliferation and promoted apoptosis of BEL-7402 hepatoma cells."
genetics_overexpression_suppress	hsa-mir-133a	Myocardial Infarction	25465869	"miR-133a overexpression protected CPCs against cell death, targeting, among others, the proapoptotic genes Bim and Bmf."
genetics_overexpression_suppress	hsa-mir-150	Myocardial Infarction	25466411	"In vivo studies showed that overexpression of miR-150 in mice resulted in improved cardiac function, reduced myocardial infarction size, inhibition of apoptosis, and reduced inflammatory Ly-6C(high) monocyte invasion levels after AMI."
genetics_overexpression_suppress	hsa-let-7b	Gastric Neoplasms	25510669	"Ectopic expression of let-7b suppressed the growth, migration, invasion, and tumorigenicity of GC cells, whereas let-7b knockdown promoted these phenotypes."
genetics_overexpression_suppress	hsa-mir-16	Glioma	25511497	miR-16 can significantly inhibit the in vivo growth of U87MG glioma.
genetics_overexpression_suppress	hsa-let-7	Gastric Neoplasms	25549793	There were significant negative correlations between serum let-7c and its target gene PGC expression
genetics_overexpression_suppress	hsa-mir-10a	Congenital Diaphragmatic Hernia	25563880	Human fetal hypoplastic CDH lungs have a specific miR-200/miR-10a signature. Survival after FETO is associated with increased miR-200 family expression. miR-200b overexpression in CDH lungs results in decreased TGF-¦Â/SMAD signaling.
genetics_overexpression_suppress	hsa-mir-200	Congenital Diaphragmatic Hernia	25563880	Human fetal hypoplastic CDH lungs have a specific miR-200/miR-10a signature. Survival after FETO is associated with increased miR-200 family expression. miR-200b overexpression in CDH lungs results in decreased TGF-¦Â/SMAD signaling.
genetics_overexpression_suppress	hsa-mir-200b	Congenital Diaphragmatic Hernia	25563880	Human fetal hypoplastic CDH lungs have a specific miR-200/miR-10a signature. Survival after FETO is associated with increased miR-200 family expression. miR-200b overexpression in CDH lungs results in decreased TGF-¦Â/SMAD signaling.
genetics_overexpression_suppress	hsa-mir-146b	Cervical Neoplasms	25572123	"miR�46b�p was able to inhibit the proliferative, invasive and adhesive potential and block the cell cycle progression of Caski human cervical cancer cells"
genetics_overexpression_suppress	hsa-mir-143	Osteosarcoma	25576341	Forced miR-143 expression significantly inhibited tumor growth in xenograft SAOS-2-Dox and U2OS-Dox animal models.
genetics_overexpression_suppress	hsa-let-7b	Uveal Melanoma	25588203	We then confirmed that let-7b mimics could inhibit UM growth both in vitro and in vivo.
genetics_overexpression_suppress	hsa-mir-214	Ischemia-Reperfusion Injury	25593579	Transfection of miR-214 mimic showed protective effects on OGD-induced injury to H9c2 cells by reducing apoptosis
genetics_overexpression_suppress	hsa-mir-17	Melanoma	25594054	"The melanoma tumors formed in mice overexpressing miR-17 were less than that in wild type mice. In addition, the miR-17 tumors were less invasive and less angiogenic."
genetics_overexpression_suppress	hsa-let-7	Neoplasms [unspecific]	25597880	let-7 microRNA would be involved in over-expression of cofilin-1 mediated tumor suppression in vitro and in vivo.
genetics_overexpression_suppress	hsa-mir-30a	Hepatitis B Virus Infection	25620738	"HBx induces autophagosome formation via beclin-1 expression, whereas miRNA-30a overexpression could successfully inhibit the beclin-1 expression induced by HBx, thereby modulating autophagosome formation in hepatic cells."
genetics_overexpression_suppress	hsa-mir-29a	Glioblastoma	25625222	"Exogenous miR-29s substantially inhibited the proliferation, migration and invasion of U87MG cells, and promoted their apoptosis."
genetics_overexpression_suppress	hsa-mir-135a	Medulloblastoma	25639612	"Remarkably, enforced expression of miR-135a in HT CSCs strongly inhibited tumorigenesis by repressing the miR-135a direct target gene Arhgef6."
genetics_overexpression_suppress	hsa-mir-133a	Heart Failure	25658461	transfecting MSCs with miR-133a mimic improves survival of MSCs as determined by the MTT assay.
genetics_overexpression_suppress	hsa-mir-124	Osteosarcoma	25667613	"transfection of miR-124 mimic into MG63 cells was able to reduce cell proliferation, invasion and migration, and promote cell apoptosis."
genetics_overexpression_suppress	hsa-mir-184	"Carcinoma, Renal Cell"	25667660	"Our studies revealed that miR-184 mimic significantly inhibits cell migration, suppresses cell proliferation and induces renal cancer cell apoptosis in vitro when compared with the negative control (P<0.05)."
genetics_overexpression_suppress	hsa-mir-16	Breast Neoplasms	25672252	"Overexpression of microRNA-16 declines cellular growth, proliferation and induces apoptosis in human breast cancer cells."
genetics_overexpression_suppress	hsa-mir-1	"Squamous Cell Carcinoma, Esophageal"	25672418	Downregulation of microRNA-1 in esophageal squamous cell carcinoma correlates with an advanced clinical stage and its overexpression inhibits cell migration and invasion.
genetics_overexpression_suppress	hsa-mir-150	"Leukemia, Lymphoblastic, Acute"	25687053	"miR-150 may be a putative oncoprotein in T-ALL cells. Overexpression of miR-150 has noticeable effects on the proliferation inhibition and apoptosis induction of Jurkat cells, which may be mediated by the negative regulation of PI3K/Akt /NF-¦ÊB signaling pathway."
genetics_overexpression_suppress	hsa-mir-21	Immune System Disease [unspecific]	25688245	miR-21 has emerged as a key mediator of the anti-inflammatory response in macrophages.
genetics_overexpression_suppress	hsa-mir-203	Brain Disease [unspecific]	25723469	enforced expression of miR-203 or MyD88 siRNA silencing inhibits downstream NF-¦Ê¦Â signaling and microglia activation
genetics_overexpression_suppress	hsa-mir-126	Spinal Cord Injuries	25724143	"increased levels of miR-126 promoted angiogenesis, and inhibited leukocyte extravasation into the injured spinal cord"
genetics_overexpression_suppress	hsa-let-7f	Glioma	25735962	"The enhanced expression of Let-7f suppressed glioma cells proliferation, migration, and invasion via direct targeting perisotin oncogenic activity."
genetics_overexpression_suppress	hsa-mir-122	Liver Neoplasms	25762642	"miR-107, mir-122, miR-29, miR-365 and miR-802 exhibited weak to moderate tumor suppressor potential."
genetics_overexpression_suppress	hsa-mir-210	Cerebral Ischemia	25783636	Rats treated with VNS showed increased miR-210 expression as well as decreased apoptosis and antioxidant stress responses compared with the I/R group
genetics_overexpression_suppress	hsa-mir-29b	Prostate Neoplasms	25784815	forced expression of miR-29b inhibited cell proliferation and cell invasion and induced cell apoptosis in PCa.
genetics_overexpression_suppress	hsa-mir-184	Retinal Neovascularization	25796186	miR-184 mimic inhibits Wnt signaling in the OIR retina
genetics_overexpression_suppress	hsa-mir-26a	Nervous System Diseases [unspecific]	25808510	We found that miR-26a up-regulation promoted neurite outgrowth and reduced apoptosis in bupivacaine-injured DRG neurons.
genetics_overexpression_suppress	hsa-mir-21	Myocardial Infarction	25809568	"In miR-21 group, myocardial infarct size reduced by 36.9% in comparison with LV-GFP group."
genetics_overexpression_suppress	hsa-let-7a	Breast Neoplasms	25846193	"Cell proliferation, colony formation, migration and invasion were decreased after overexpression of let-7a in breast cancer cells and vice versa."
genetics_overexpression_suppress	hsa-mir-193b	Adenovirus Infection	25854561	The over-expression of miR-193b may suppress the proliferation of K562 cells.
genetics_overexpression_suppress	hsa-mir-206	Medulloblastoma	25859932	"MiR-206, a Cerebellum Enriched miRNA Is Downregulated in All Medulloblastoma Subgroups and Its Overexpression Is Necessary for Growth Inhibition of Medulloblastoma Cells."
genetics_overexpression_suppress	hsa-mir-26a	Graft-Versus-Host Disease	25865461	The prolonged allograft survival induced by LV-Mir-26a was also completely abrogated by IL-6 overexpression.
genetics_overexpression_suppress	hsa-let-7a	"Carcinoma, Nasopharyngeal"	25884389	"synthetic let-7a mimics suppressed NPC cells migration, invasion and EMT process and knockdown of HMGA2 was consistent with the effects of let-7a in NPC cells."
genetics_overexpression_suppress	hsa-mir-146a	Atherosclerosis	25904598	cellular enrichment of miR-146a through the systemic delivery of miR-146a mimetics in Apoe(-/-)Ldlr(-/-) and Ldlr(-/-) mice attenuated monocyte/macrophage activation and atherosclerosis in the absence of plasma lipid reduction.
genetics_overexpression_suppress	hsa-mir-145	Malignant Neoplasms [unspecific]	25926306	"cell proliferation level of OS-732 with microRNA-145 overexpression was significantly decreased, and OS-732 cell invasion capacity was also significantly decreased"
genetics_overexpression_suppress	hsa-mir-145	Prostate Neoplasms	25951106	Overexpression of miR-145-5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression.
genetics_overexpression_suppress	hsa-mir-133a	Heart Failure	25960234	The miR-133a mimic and miR-133a overexpression significantly caused a decrease in the fibrosis of heart in chronic heart failure rats.
genetics_overexpression_suppress	hsa-mir-138	"Carcinoma, Gallbladder"	25962180	Expression of miR-138 is frequently reduced in gallbladder carcinoma when compared to normal cells. Overexpression of miR-138 inhibited cell proliferation by directly suppressing the expression of Bag-1. These results suggest that miR-138 plays an important role in inhibiting the growth of gallbladder carcinoma.
genetics_overexpression_suppress	hsa-mir-95	"Adenocarcinoma, Lung"	25971210	Overexpression of microRNA-95-3p suppresses brain metastasis of lung adenocarcinoma through downregulation of cyclin D1.
genetics_overexpression_suppress	hsa-mir-202	Multiple Myeloma	25971527	The growth rate of miR-202 mimics transfection cells was significantly lower than that of non-transfected cells.
genetics_overexpression_suppress	hsa-mir-133a	Vascular Hypertrophy	25995211	delivery of miR-1 and miR-133a suppressed inducible cAMP early repressor expression and prevented both electrical remodeling and hypertrophy.
genetics_overexpression_suppress	hsa-mir-100	Osteosarcoma	26018508	Overexpression of miR-100 inhibits growth of osteosarcoma through FGFR3.
genetics_overexpression_suppress	hsa-mir-214	Ischemia-Reperfusion Injury	26025394	214 may participate in the protective function of ischemic post conditioning by down regulating HIF1AN.
genetics_overexpression_suppress	hsa-mir-16	Sarcoma [unspecific]	26044957	"miR-16, but not other downregulated miRNAs, was able to significantly suppress both migration and invasion in vitro"
genetics_overexpression_suppress	hsa-mir-146a	Sepsis	26048146	In vivo transfection of LmiR-146a attenuated sepsis-induced cardiac dysfunction.
genetics_overexpression_suppress	hsa-mir-506	Breast Neoplasms	26059632	"MiR-506 over-expression significantly inhibits the proliferation,colony formation, and migration of breast cancer cells. miR-506 over-expression may thus be able to improve the malignant phenotype of breast cancer cells."
genetics_overexpression_suppress	hsa-mir-16	"Adenocarcinoma, Lung"	26064212	enforced expression of mir-16 lead to reduced A549 cell proliferation and promote apoptosis.
genetics_overexpression_suppress	hsa-mir-195	Colorectal Carcinoma	26064276	has-miR-195 can promote cell apoptosis and inhibit the invasion and metastasis by inhibiting the expression of Bcl-2.
genetics_overexpression_suppress	hsa-mir-98	Neuroinflammation	26126865	"Overexpression of let-7 and miR-98 in vitro and in vivo resulted in reduced leukocyte adhesion to and migration across endothelium, diminished expression of pro-inflammatory cytokines, and increased BBB tightness, attenuating barrier 'leakiness' in neuroinflammation conditions."
genetics_overexpression_suppress	hsa-mir-138	Cardiovascular Diseases [unspecific]	26129883	over-expression of miR-138 significantly enhanced the cell growth and significantly attenuated the cell apoptosis in hypoxic conditions.
genetics_overexpression_suppress	hsa-mir-29a	Prostate Neoplasms	26131109	"enforced expression of miR-29a in PC-3 and LNCaP cells inhibited proliferation, and induced apoptosis by repressing the expression of KDM5B."
genetics_overexpression_suppress	hsa-mir-146a	Sepsis	26138422	"Up-regulation of miR-146a inhibit the release of the inflammatory cytokine TNF-α stimulated by sepsis, and alleviate inflammatory reaction and lung tissue injury in mice with sepsis-induced ALI."
genetics_overexpression_suppress	hsa-mir-27b	Cardiovascular Diseases [unspecific]	26161255	miR-27b mimic had overall beneficial effects
genetics_overexpression_suppress	hsa-mir-573	Rheumatoid Arthritis	26166764	miR-573 overexpression suppressed the expression of interleukin 6 (IL-6) and cyclooxygenase 2 in RASFs
genetics_overexpression_suppress	hsa-mir-137	Melanoma	26186482	overexpression of miR-137 inhibited the proliferation of melanoma cells
genetics_overexpression_suppress	hsa-mir-34c	Diabetic Nephropathy	26191142	miR-34c was downregulated and that overexpression of miR-34c inhibited HG-induced podocyte apoptosis.
genetics_overexpression_suppress	hsa-mir-221	Astrocytoma	26191177	Overexpression of miR-221 inhibits proliferation and promotes apoptosis of human astrocytoma cells.
genetics_overexpression_suppress	hsa-mir-23b	Neoplasms [unspecific]	26198058	"miR-23b, miR-199a, and miR-15a displayed increased expression during early AVC development whereas others such as miR-130a and miR-200a display decreased expression levels"
genetics_overexpression_suppress	hsa-mir-26a	"Diabetes Mellitus, Type 2"	26208605	Mir-26a suppresses autoimmune diabetes in NOD mice in part through promoted regulatory T cells (Tregs) expression.
genetics_overexpression_suppress	hsa-mir-140	Osteosarcoma	26219893	"relative miR-140 expression was increased, cell proliferation was inhibited, cell population in G0/G1 phase was increased, cell population in G2/M phase and S phases and proliferation index (PI), and cell migration distance were decreased in the miR-140 mimic group"
genetics_overexpression_suppress	hsa-mir-210	Osteoarthritis	26244598	"Transfection with miR-210 mimic inhibited LPS-induced pro-inflammatory cytokines production, cell viability reduction and cell apoptosis."
genetics_overexpression_suppress	hsa-mir-1	Vascular Hypertrophy	26253469	the administration of a miR-1 mimic attenuated cardiac hypertrophy by suppressing the transverse aortic constriction-induced increase in myocardin expression
genetics_overexpression_suppress	hsa-mir-302b	"Carcinoma, Hepatocellular"	26254095	Overexpression of miR-302b suppressed HCC cell invasion and metastasis.
genetics_overexpression_suppress	hsa-mir-143	Prostate Neoplasms	26269764	"miR-143 has an inhibitory effect on cell proliferation as evidenced by decreased cell viability, increased cell apoptosis and cell cycle arrest at the G1/S transition."
genetics_overexpression_suppress	hsa-mir-125a	Colon Neoplasms	26297542	overexpression of miR-125a-5p inhibited cell proliferation and induced cell apoptosis in colon cancer cells.
genetics_overexpression_suppress	hsa-mir-31	"Adenocarcinoma, Lung"	26299665	overexpression of miR-31 led to the inhibition of adenocarcinoma cell proliferation.
genetics_overexpression_suppress	hsa-mir-206	"Carcinoma, Lung, Non-Small-Cell"	26309565	"Forced overexpression of miR-206 significantly inhibited cell proliferation, migration and invasion of NSCLC cells."
genetics_overexpression_suppress	hsa-mir-26a	Ischemia-Reperfusion Injury	26320674	Mir-26a overexpression results in attenuated cardiac IR injury and inhibited HMGB1 expression.
genetics_overexpression_suppress	hsa-mir-33b	Colorectal Carcinoma	26329295	miR-33b inhibited tumor cell growth and induced cell cycle arrest.
genetics_overexpression_suppress	hsa-mir-9	Inflammation	26354749	"miR-9 overexpression significantly repressed NF-κB expression and, thereby, suppressed inflammation but promoted LEC tube formation"
genetics_overexpression_suppress	hsa-mir-9	Spinal Cord Injuries	26359086	miR-9 overexpression promoted osteoblast differentiation and angiogenesis
genetics_overexpression_suppress	hsa-mir-634	Cervical Neoplasms	26367112	"miR-634 inhibited cell proliferation, migration and invasiveness in cervical cancer cells and the block of miR-634 enhances the mTOR expression at both the mRNA and protein levels which regulated the expression of mTOR negatively."
genetics_overexpression_suppress	hsa-mir-16	Glioblastoma	26373393	"Overexpression of microRNA- 16 in the A172 and U87 GBM cell lines inhibited the activities of co-cultured endothelial cells, including proliferation, migration, extension and tubule formation."
genetics_overexpression_suppress	hsa-mir-145	Glioblastoma	26374689	"CSCs expressed low levels of miR-145, and its introduction decreased self-renewal through reductions in AKT signaling and stem cell marker (SOX2, OCT4, and NANOG) expression"
genetics_overexpression_suppress	hsa-mir-449a	Liver Neoplasms	26375440	"Overexpression of miR-449a inhibited cell proliferation, induced G1 phase arrest and cell apoptosis in liver cancer."
genetics_overexpression_suppress	hsa-mir-1	Myocardial Infarction	26380976	miR-1 and -21 jointly blocked hypoxia-induced cardiomyocytes apoptosis.
genetics_overexpression_suppress	hsa-mir-21	Myocardial Infarction	26380976	miR-1 and -21 jointly blocked hypoxia-induced cardiomyocytes apoptosis.
genetics_overexpression_suppress	hsa-mir-16	"Carcinoma, Nasopharyngeal"	26383521	"we identified upregulation of tumor suppressor miR-16a, which inhibited cell cycle progression and sensitized NPC cells to chemotherapy."
genetics_overexpression_suppress	hsa-mir-221	Ischemia-Reperfusion Injury	26396139	"Mimics of miRNA-221, -150, and -206 were protective in both H9c2 and NRVM."
genetics_overexpression_suppress	hsa-mir-133a	"Cardiomyopathy, Hypertrophic"	26403739	miR-133a is an important regulator of phenylephrine-induced cardiomyocyte hypertrophy and negatively regulates this process.
genetics_overexpression_suppress	hsa-mir-7	Adrenal Cortex Neoplasms	26452132	microRNA-7-5p (miR-7) reduces cell proliferation in vitro and induces G1 cell cycle arrest.
genetics_overexpression_suppress	hsa-mir-125b	Cholangiocarcinoma	26455324	"We also found that enforced expression of let-7c, miR-99a or miR-125b could reduce the activity of STAT3 and further suppress CCA tumorigenicity in vivo and inhibit the migration and invasion of CCA cells in vitro."
genetics_overexpression_suppress	hsa-mir-34a	Alzheimer Disease	26459758	"Importantly, the overexpression of TAp73α and miR-34a reversed cell cycle-related neuronal apoptosis (CRNA)."
genetics_overexpression_suppress	hsa-mir-140	Rheumatoid Arthritis	26473405	"Overexpression of miRNAs 140-3p and 140-5p caused a reduction in expression, with correlated kinetic patterns, of their corresponding target molecules sirtuin 1 and stromal cell-derived factor 1 in the SFs and joints of mice."
genetics_overexpression_suppress	hsa-mir-29a	"Carcinoma, Thyroid, Papillary"	26482618	"overexpression of miR-29a markedly suppressed PTC cell proliferation, migration, and invasion and promoted PTC apoptosis and cell cycle arrest at G0/G1 phase."
genetics_overexpression_suppress	hsa-mir-29c	"Carcinoma, Embryonal"	26484393	MicroRNA-29c overexpression inhibits proliferation and promotes apoptosis and differentiation in P19 embryonal carcinoma cells.
genetics_overexpression_suppress	hsa-mir-26a	"Carcinoma, Lung, Non-Small-Cell"	26492332	"Overexpression of miR-26a in A549 cells inhibited G1-S transition, increased cell death in response to CDDP treatment, and decreased the colony formation of A549 cells."
genetics_overexpression_suppress	hsa-mir-214	"Carcinoma, Hepatocellular"	26498144	Overexpression of miR-214 in HCC cells inhibited proliferation by inducing G1-S checkpoint arrest.
genetics_overexpression_suppress	hsa-mir-138	Laryngeal Neoplasms	26499780	"miR-138 overexpression inhibited ZEB2-mediated cell invasiveness, while miR-138 depletion increased ZEB2-mediated cell invasiveness in LC cells."
genetics_overexpression_suppress	hsa-mir-16	"Carcinoma, Hepatocellular"	26499886	"The results of this study suggest that the overexpression of miR-16 inhibits the proliferation, invasion and metastasis of HepG2 HCC cells, and that these effects are associated with the PI3K/Akt signaling pathway."
genetics_overexpression_suppress	hsa-mir-152	Cervical Neoplasms	26515145	Overexpression of miR-152 repressed WNT1 and ERBB3 expression and decreased proliferation of HeLa cells.
genetics_overexpression_suppress	hsa-mir-222	"Squamous Cell Carcinoma, Tongue"	26517090	"Moreover, miR-222 mimics and ABCG2 siRNA inhibited tumor growth and lung metastasis in vivo."
genetics_overexpression_suppress	hsa-mir-449a	Prostate Neoplasms	26520443	"Overexpression of miR-449a induces cell cycle arrest, apoptosis, and senescence"
genetics_overexpression_suppress	hsa-mir-205	"Carcinoma, Skin"	26527515	"Ectopic expression of miR-205-5p in spindle cancer cells reduces Rap1a, mitigates cell invasiveness, decreases proliferation, and delays tumor onset."
genetics_overexpression_suppress	hsa-mir-195	Thyroid Neoplasms	26527888	exogenous overexpression of miR-195 significantly inhibits the protein expression of Raf1 and blocks the thyroid cancer cell proliferation.
genetics_overexpression_suppress	hsa-let-7b	Myocardial Ischemic-Reperfusion Injury	26542107	intramyocardial injection of let-7b-modified MSCs significantly enhanced ventricular function and facilitated myocardial repair by protecting transplanted cells from apoptosis and autophagy in the rat cardiac ischemia-reperfusion model.
genetics_overexpression_suppress	hsa-mir-363	Head And Neck Neoplasms	26545583	"These findings demonstrate that the overexpression of miR-363 reduces cellular migration in head and neck cancer and reveal the biological relationship between miR-363, myosin 1b, and HPV-positive SCCHN."
genetics_overexpression_suppress	hsa-mir-150	Osteosarcoma	26561465	"restoration of miR-150 expression in OS cells could inhibit cell proliferation, migration, and invasion and induced apoptosis in vitro as well as suppressed tumor growth of OS in vivo."
genetics_overexpression_suppress	hsa-mir-7-1	Glioblastoma	26573275	"In conclusion, our results clearly demonstrated that overexpression of miR-7-1-3p augmented the anti-tumor activities of LUT and SIL to inhibit autophagy and induce apoptosis for controlling growth of different human glioblastomas in vivo."
genetics_overexpression_suppress	hsa-mir-15a	"Carcinoma, Hepatocellular"	26581909	"Ectopic overexpression of miR-15a-5p suppressed cancer proliferation, induced cell cycle arrest in HepG2 or SNU-182 cells in vitro, and inhibited HCC tumor growth in vivo."
genetics_overexpression_suppress	hsa-mir-16	Alzheimer Disease	26592823	Overexpression and inhibition of miR-16 in the cellular AD model with primary hippocampal neurons decreased and increased apoptosis
genetics_overexpression_suppress	hsa-mir-125b	Melanoma	26596831	Restored expression of miR-125b in melanoma suppressed cell proliferation and invasion both in vitro and in vivo.
genetics_overexpression_suppress	hsa-mir-100	Ovarian Neoplasms	26607088	The expression of miR-100 is downregulated in SKOV3/DDP cells.Overexpressing miR-100 may effectively increase the sensitivity to cisplatin of human ovarian epithelial cancer SKOV3/DDP cells and may reverse cisplatin-resistance of EOC (epithelial ovarian cancer).
genetics_overexpression_suppress	hsa-mir-145	"Carcinoma, Hepatocellular"	26615424	"Overexpression of miR-145 in HCC cell lines significantly inhibited cell proliferation, migration, and invasion in vitro."
genetics_overexpression_suppress	hsa-mir-143	Breast Neoplasms	26618772	"Up-regulating miR-143 enhanced E-cadherin-mediated cell-cell adhesion ability, reduced mesenchymal markers, and decreased cell proliferation, migration, and invasion in vitro."
genetics_overexpression_suppress	hsa-mir-18a	"Carcinoma, Gastric"	26622381	The results showed that miR-18a overexpression was able to promote cell apoptosis and inhibit cell invasion.
genetics_overexpression_suppress	hsa-mir-182	Glioma	26622652	"overexpression of miR-182 affected cell cycle regulation and cell migration capacity in vitro, which may have been associated with the promotion of apoptosis by this molecule."
genetics_overexpression_suppress	hsa-mir-195	Cervical Neoplasms	26622903	"The expression of miR-195 mimics in the cervical cancer HeLa cell line significantly decreased the cell proliferation, migration and invasion capacities in vitro."
genetics_overexpression_suppress	hsa-mir-302b	Breast Neoplasms	26623722	"miR-302b overexpression enhances sensitivity to cisplatin in breast cancer cell lines, reducing cell viability and proliferation in response to the treatment."
genetics_overexpression_suppress	hsa-mir-195	Cervical Neoplasms	26631043	overexpression of miR-195 played a suppressor role in the proliferation of HeLa and SiHa cells and promoted cell apoptosis.
genetics_overexpression_suppress	hsa-mir-195	Breast Neoplasms	26632252	"ectopic expression of hsa-miR-195 in MCF-7 and MDA-MB-231 cells not only altered cellular cholesterol and triglyceride levels significantly but also resulted in reduced proliferation, invasion and migration."
genetics_overexpression_suppress	hsa-mir-1	Cardiomegaly	26638879	miRNA-1 overexpression prevented cardiomyocyte hypertrophy.
genetics_overexpression_suppress	hsa-mir-16	"Lymphoma, Non-Hodgkin"	26640145	The miR-16 transfection significantly decreased senescent cells and increased apoptotic cells
genetics_overexpression_suppress	hsa-mir-16	"Lymphoma, T-Cell, Cutaneous"	26640145	The miR-16 transfection significantly decreased senescent cells and increased apoptotic cells
genetics_overexpression_suppress	hsa-mir-16	"Carcinoma, Nasopharyngeal"	26655091	"Ectopic expression of miR-16 suppressed NPC cell proliferation, migration, and invasion in vitro and inhibited tumor growth and metastatic colonization in the lung in vivo."
genetics_overexpression_suppress	hsa-mir-372	"Carcinoma, Endometrial"	26673619	miR-372 overexpression suppressed tumor growth
genetics_overexpression_suppress	hsa-mir-222	Osteoarthritis	26673737	Over-expression of miR-222 significantly suppressed apoptotic death by down-regulating HDAC-4 and MMP-13 level.
genetics_overexpression_suppress	hsa-mir-30a	"Carcinoma, Ovarian"	26675258	"Overexpression of miR-30a decreased Akt and mitogen activated protein kinase signaling pathway activation, cell proliferation, invasion, plasticity, EMT marker levels, and vascular endothelial growth factor release."
genetics_overexpression_suppress	hsa-mir-215	Ovarian Neoplasms	26676658	"Upregulation of miR-215 inhibited cell proliferation, promoted apoptosis and increased sensitivity to chemotherapy drugs in EOC cells."
genetics_overexpression_suppress	hsa-mir-192	"Carcinoma, Hepatocellular"	26684241	miR-192 significantly suppressed metastasis of HCC cells in vitro and in vivo.
genetics_overexpression_suppress	hsa-mir-181d	"Squamous Cell Carcinoma, Oral"	26693182	Ectopic expression of miR-181a/d decreased anchorage independent growth and CSC phenotype of HPV16-transfected OSCC.
genetics_overexpression_suppress	hsa-mir-494	"Carcinoma, Ovarian"	26695144	"overexpression of miR-494 in EOC cells could remarkably inhibit proliferation, colony formation, migration, and invasion and induce cell apoptosis, G0/G1 phase arrest."
genetics_overexpression_suppress	hsa-mir-1	"Cardiomyopathy, Hypertrophic"	26699910	"miR-1 mimic, in parallel to CDK6 siRNA, could inhibit PE-induced hypertrophy of NRVCs, with decreases in cell size"
genetics_overexpression_suppress	hsa-mir-148a	Breast Neoplasms	26707142	The ectopic miR-148a expression inhibited the migration and invasion of MCF-7 and MDA-MB-231 breast cancer cells.
genetics_overexpression_suppress	hsa-mir-145	Breast Neoplasms	26715279	"Overexpression of miR-145 in MCF-7 and BT-549 cell lines significantly inhibited cell proliferation, migration, and invasion in vitro."
genetics_overexpression_suppress	hsa-mir-206	"Carcinoma, Renal Cell, Clear-Cell"	26718123	"upregulation of miR-206 inhibited renal cancer cell proliferation, invasion and migration"
genetics_overexpression_suppress	hsa-mir-452	"Carcinoma, Lung, Non-Small-Cell"	26718215	"xpression of miR-452 via adenoviral (Ad) vector inhibits the proliferation, invasion, and migration of NSCLC cells A549 or H460."
genetics_overexpression_suppress	hsa-mir-143	Prostate Neoplasms	26721309	miR-143 restoration decreased secreted MMP-2 and MMP-9 enzyme activities compared with scramble controls
genetics_overexpression_suppress	hsa-mir-34c	"Carcinoma, Hepatocellular, HBV-Related"	26722295	"The restoration of miR-34c in HepG2.2.15 cells suppressed TGIF2 expression, HBV replication and viral antigen synthesis; inhibited cell proliferation; and induced apoptosis."
genetics_overexpression_suppress	hsa-mir-34a	Prostate Neoplasms	26722316	The over-expression of miR-34a inhibited PC-3 cells growth and resulted in increased cell cycle arrest compared with the negative control (P<0.05).
genetics_overexpression_suppress	hsa-mir-145	"Carcinoma, Breast, Triple Negative"	26733177	tumor necrosis factor-alpha (TNF-α)-induced apoptosis was expanded by the transfection of miR-145 in MDA-MB-231 which belongs to the TNBC cell lines.
genetics_overexpression_suppress	hsa-mir-488	Gastric Neoplasms	26738864	"The ectopic expression of miR-488 suppressed the GC cell proliferation, cell cycle, colony information, and migration."
genetics_overexpression_suppress	hsa-mir-125b	Osteosarcoma	26744308	"stable overexpression of miR-125b in osteosarcoma cell lines U2OS and MG-63 inhibited cell proliferation, migration, and invasion."
genetics_overexpression_suppress	hsa-let-7	Gastric Neoplasms	26745603	"overexpression of miR-let-7a markedly suppressed the proliferation, migration, and invasion of GC cells by down-regulating the expression of PKM2."
genetics_overexpression_suppress	hsa-mir-23b	Asthma	26748386	Overexpression of miR-23b significantly inhibited TGF-β1-induced ASMCs proliferation and promoted apoptosis.
genetics_overexpression_suppress	hsa-mir-378	Breast Neoplasms	26749280	"ectopic expression of miR-378 in MDA-MB-231 cells inhibited Runx1 and suppressed migration and invasion, while inhibition of miR-378 in MCF7 cells increased Runx1 levels and cell migration."
genetics_overexpression_suppress	hsa-let-7f	Glioma	26750768	inhibiting the pro-migratory function of POSTN by the overexpression of miR-Let-7f significantly reduced the formation of VM.
genetics_overexpression_suppress	hsa-mir-320	Cervical Neoplasms	26753959	"miR-320 induces apoptosis via down-regulation of Mcl-1 and activation of caspase-3 but inhibits cell proliferation, migration, invasion, and tumorigenesis in cervical cancer cells."
genetics_overexpression_suppress	hsa-mir-340	Breast Neoplasms	26758430	miR-340 could dramatically down-regulate metastasis by targeting Wnt signaling in breast cancer cells.
genetics_overexpression_suppress	hsa-mir-143	"Squamous Cell Carcinoma, Esophageal"	26758433	"miR-143 exerted a tumor-suppressing effect by inhibiting the proliferation, migration, and invasion and inducing G1/G0 phase arrest of ESCC cells via the negative regulation of FAM83F expression."
genetics_overexpression_suppress	hsa-mir-381	Ovarian Neoplasms	26768613	"Overexpression of miR-381 significantly inhibited EOC cell proliferation, migration, and invasion."
genetics_overexpression_suppress	hsa-mir-503	Osteosarcoma	26768615	miR-503 overexpression suppressed cell invasion and migration and inhibited epithelial-to-mesenchymal transition (EMT) of MG-63.
genetics_overexpression_suppress	hsa-mir-29a	Multiple Myeloma	26771839	"In addition, ectopic expression of miRNA-29a or exposure to PRIMA-1Met reduced cell proliferation and induced apoptosis in MM cells."
genetics_overexpression_suppress	hsa-mir-30a	"Carcinoma, Urothelial"	26775686	Both miR-30a and small interfering RNA Notch1 negatively regulated cell proliferation
genetics_overexpression_suppress	hsa-mir-210	Hypoxia	26780211	miR-210 upregulation exerted amelioration on the hypoxia-induced apoptosis
genetics_overexpression_suppress	hsa-mir-27b	Gastric Neoplasms	26780940	miR-27b overexpression significantly inhibited H. pylori infection-induced cell proliferation and WNT signaling pathway activation in gastric cancer cells.
genetics_overexpression_suppress	hsa-mir-20a	"Squamous Cell Carcinoma, Oral"	26781875	"Upregulation of miR-20a by transfected plasmid HPV-16 E7 can significantly inhibit Cal27 cell proliferation, invasion, and migration."
genetics_overexpression_suppress	hsa-mir-214	"Carcinoma, Hepatocellular"	26788207	enhanced expression of miR-214 or silencing of E2F3 inhibited the proliferation of HCC SMMC-7721 cells.
genetics_overexpression_suppress	hsa-mir-382	Colorectal Carcinoma	26800338	"Transfection with miR-382 mimics impeded the growth, migration, and invasion of CRC cells."
genetics_overexpression_suppress	hsa-mir-125b	Bladder Neoplasms	26807182	"Overexpression of miR-125b inhibited cellular growth, suppressed cellular migration and caused an accumulation of cells in the G1 phase of the cell cycle"
genetics_overexpression_suppress	hsa-mir-152	Colorectal Carcinoma	26820128	restoring the expression of miR-152 in CRC cells dramatically reduced the cell proliferation and cell migration and invasion and promoted apoptosis
genetics_overexpression_suppress	hsa-mir-451	Rheumatoid Arthritis	26823778	miR-451 treatment significantly decreased cell proliferation ability
genetics_overexpression_suppress	hsa-mir-30a	"Adenocarcinoma, Lung"	26837415	overexpression of miR-30a in A549 cells inhibited migration and invasion but not cell proliferation and cell cycle progression
genetics_overexpression_suppress	hsa-mir-137	Gastric Neoplasms	26840256	Overexpression of miR-9 and miR-137 downregulated the CUL4A-LATS1-Hippo signaling pathway and suppressed GC cell proliferation and invasion in vitro.
genetics_overexpression_suppress	hsa-mir-9	Gastric Neoplasms	26840256	Overexpression of miR-9 and miR-137 downregulated the CUL4A-LATS1-Hippo signaling pathway and suppressed GC cell proliferation and invasion in vitro.
genetics_overexpression_suppress	hsa-mir-21	Ischemia	26841045	over-expressing miR-21 in UCBMSCs could improve neovascularization in CLI
genetics_overexpression_suppress	hsa-mir-448	Gastric Neoplasms	26852749	"Ectopic expression of miR-448 suppressed GC cell proliferation, colony formation, and invasion."
genetics_overexpression_suppress	hsa-mir-200b	Endometriosis	26854065	"up-regulation of miR-200b reverts EMT, emerging as a potential therapeutic approach to inhibit endometriotic cell motility and invasiveness."
genetics_overexpression_suppress	hsa-mir-373	Glioma	26858153	"although miR-373 does not affect cell growth of U251, it inhibits migration and invasion of U251."
genetics_overexpression_suppress	hsa-mir-144	"Lymphoma, Large B-Cell"	26865454	"forced expression of miR-144 significantly attenuated cell proliferation and invasion of OCI-Ly3 cells in vitro, and the tumor-suppressor effect of miR-144 was also confirmed using a xenograft mouse model in vivo Taken together"
genetics_overexpression_suppress	hsa-mir-150	"Carcinoma, Hepatocellular"	26871477	"miR-150 overexpression inhibited cell proliferation, migration and invasion in vitro and tumor growth and metastasis in vivo."
genetics_overexpression_suppress	hsa-mir-19a	Lung Fibrosis	26873752	"intratracheal application of miR-19a, -19b, and 26b reduced the pulmonary fibrotic severity induced by bleomycin"
genetics_overexpression_suppress	hsa-mir-19b	Lung Fibrosis	26873752	"intratracheal application of miR-19a, -19b, and 26b reduced the pulmonary fibrotic severity induced by bleomycin"
genetics_overexpression_suppress	hsa-mir-26b	Lung Fibrosis	26873752	"intratracheal application of miR-19a, -19b, and 26b reduced the pulmonary fibrotic severity induced by bleomycin"
genetics_overexpression_suppress	hsa-mir-223	Breast Neoplasms	26876200	both RT-induced miR-223 and peri-operative inhibition of EGFR efficiently prevented BC cell growth and reduced recurrence formation in mouse models of BC.
genetics_overexpression_suppress	hsa-mir-203	"Squamous Cell Carcinoma, Head and Neck"	26882562	"oreover, ectopic overexpression of miR-203 suppressed the invasion and induced mesenchymal-epithelial transition (MET) in HNSCC cells."
genetics_overexpression_suppress	hsa-mir-451	"Carcinoma, Renal Cell"	26884830	"microRNA-451 inhibited proliferation, migration and invasion of renal cell carcinomas cells."
genetics_overexpression_suppress	hsa-mir-15b	Liver Neoplasms	26884837	MiR-15b mimic transfection promoted miR-15b overexpression and inhibited HepG2 cell proliferation significantly
genetics_overexpression_suppress	hsa-mir-26b	"Carcinoma, Hepatocellular"	26891666	miR-26b-5p inhibited HCC cell growth and impaired the tube formation ability of the HCC cells
genetics_overexpression_suppress	hsa-mir-15a	Gastric Neoplasms	26894855	ectopic expression of miR-15a decreased Bmi-1 in gastric cancer cell lines with reduced proliferation and tumor invasion.
genetics_overexpression_suppress	hsa-mir-23b	Prostate Neoplasms	26898757	miR-23b/-27b expression in prostate cancer cells decreased seminal vesicle invasion and distant metastases
genetics_overexpression_suppress	hsa-mir-27b	Prostate Neoplasms	26898757	miR-23b/-27b expression in prostate cancer cells decreased seminal vesicle invasion and distant metastases
genetics_overexpression_suppress	hsa-mir-99a	Cardiovascular Diseases [unspecific]	26914935	Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy.
genetics_overexpression_suppress	hsa-mir-146a	Glioblastoma	26916895	The upregulation of miR-146a in glioma cells through miR-146a mimic transfection led to reduction of cell viability and to an increase in the percentage of apoptosis.
genetics_overexpression_suppress	hsa-mir-19b	Myocardial Ischemic-Reperfusion Injury	26918829	we found that overexpression of miR-19b decreased H2O2-induced apoptosis and improved cell survival
genetics_overexpression_suppress	hsa-mir-200b	"Carcinoma, Hepatocellular"	26919246	"Forced expression of microRNA-200b in HCC cells dramatically repressed proliferation, colony formation, cell cycle progression, and invasion."
genetics_overexpression_suppress	hsa-mir-24	"Carcinoma, Nasopharyngeal"	26922862	cell proliferation was suppressed and radiosensitivity increased when miR-24 was ectopically expressed in NPC cells.
genetics_overexpression_suppress	hsa-mir-34b	Osteosarcoma	26924291	Upregulation of miR-34b also induced apoptosis and increased the sensitivity of the cells to the anticancer drugs
genetics_overexpression_suppress	hsa-mir-372	Gastric Neoplasms	26928593	inhibit proliferations of adenocarcinoma gastric cancer (AGS) cells overexpressing these miRNAs
genetics_overexpression_suppress	hsa-mir-27a	Endometrial Neoplasms	26934121	Enforced expression of miR-124 suppresses EC cell invasion and proliferation.
genetics_overexpression_suppress	hsa-mir-204	"Carcinoma, Lung, Non-Small-Cell"	26935060	"Transient over-expression of miR-204 by transfecting with miR-204 mimics suppressed NSCLC cell proliferation, migration, and induced apoptosis and G1 arrest"
genetics_overexpression_suppress	hsa-mir-200b	"Carcinoma, Cervical"	26935156	miR�00b suppressed the migratory potential of cervical carcinoma cells
genetics_overexpression_suppress	hsa-mir-200c	"Carcinoma, Lung, Non-Small-Cell"	26935975	Overexpression of miR�00c significantly suppressed cell migration and invasion of A549 NSCLC cells.
genetics_overexpression_suppress	hsa-mir-141	Neuroblastoma	26936280	"lentivirus-induced miR-141 upregulation inhibited cancer proliferation, cell cycle progression, migration and increased cisplatin chemosensitivity in vitro."
genetics_overexpression_suppress	hsa-mir-181a	"Lymphoma, Large B-Cell"	26941399	"miR-181a decreases DLBCL tumor cell proliferation and survival, and anti-miR-181a abrogates these effects."
genetics_overexpression_suppress	hsa-mir-21	Acute Myocardial Infarction	26978580	combination of miR-21 and miR-146a has a greater protective effect against cardiac ischemia/hypoxia-induced apoptosis
genetics_overexpression_suppress	hsa-mir-1	Colorectal Carcinoma	26980745	The ectopic expression of these miRs induced growth suppression and autophagic cell death
genetics_overexpression_suppress	hsa-mir-200b	"Carcinoma, Hepatocellular"	26986232	"Upregulated miR�00b expression in HepG2 cells led to a decrease in DNMT3a expression levels, and an inhibition of cell proliferation."
genetics_overexpression_suppress	hsa-mir-508	Glioma	27003587	over-expression of miR-508-5p was found to decrease glioma cell growth.
genetics_overexpression_suppress	hsa-mir-7	Parkinson Disease	27003614	The upregulation of miR-7 promoted cell viability and suppressed cell apoptosis in MPP(+)-treated SH-SY5Y cells.
genetics_overexpression_suppress	hsa-mir-182	Ischemic Diseases [unspecific]	27008992	Both exogenous miR-182 and Kenpaullone significantly suppressed hypoxia-induced cardiomyocyte death in vitro.
genetics_overexpression_suppress	hsa-mir-134	Glioma	27012554	upregulated miR-134 expression restrained the proliferation and invasion of U251 cells in vitro.
genetics_overexpression_suppress	hsa-mir-154	Glioblastoma	27013470	overexpression of miR-154 suppressed cell migration and invasion of U87 and U251 cells.
genetics_overexpression_suppress	hsa-mir-20a	Liver Diseases [unspecific]	27019188	miR-20a-5p mimic could reverse high glucose-induced impaired glycogenesis and AKT/GSK activation in NCTC1469 and Hep1-6 cells.
genetics_overexpression_suppress	hsa-mir-490	Colorectal Carcinoma	27037061	miR-490-3p suppresses cancer cell proliferation by inducing apoptosis
genetics_overexpression_suppress	hsa-let-7	"Carcinoma, Salivary Adenoid Cystic"	27042128	"the overexpression of miR-98 in ACC-M cells inhibited cell proliferation, invasion, and migration in vitro."
genetics_overexpression_suppress	hsa-mir-130b	Ovarian Neoplasms	27048832	overexpression of miR-130b reduced the expression of RUNX3 and inhibited cancer cell migration and invasion of EOC cells
genetics_overexpression_suppress	hsa-mir-206	Muscle Atrophy	27054781	Injection of miR-206 (30 μg/rat) attenuated morphological and physiological deterioration of muscle characteristics
genetics_overexpression_suppress	hsa-mir-429	Bladder Neoplasms	27058893	Exogenous mimic of miR-429 treatment dramatically inhibited the migratory ability of T24 cells.
genetics_overexpression_suppress	hsa-mir-221	Neuropathic Pain	27059231	"Intrathecal injection of a miR-221 inhibitor attenuated CCI-induced mechanical allodynia and thermal hyperalgesia, and reduced proinflammatory cytokine expression"
genetics_overexpression_suppress	hsa-mir-29a	Endomyocardial Fibrosis	27060017	over-expression of miRNA-29a suppresses cardiac fibroblasts proliferation.
genetics_overexpression_suppress	hsa-mir-506	Pancreatic Neoplasms	27065335	"miR-506 inhibited cell proliferation, induced cell cycle arrest at the G1/S transition and enhanced apoptosis and chemosensitivity of pancreatic cancer cells."
genetics_overexpression_suppress	hsa-mir-101	Osteosarcoma	27073439	"Independent inhibition of c-FOS and overexpression of miR-101 expression levels significantly suppressed U2OS cell proliferation, migration and invasion (P<0.01)."
genetics_overexpression_suppress	hsa-mir-124	"Carcinoma, Lung, Non-Small-Cell"	27073840	Overexpression of miR-124 apparently suppressed the proliferation and invasion of NSCLC cell lines in vitro.
genetics_overexpression_suppress	hsa-mir-154	Prostate Neoplasms	27074041	"The forced expression of miR-154-5p or E2F5 knockdown significantly restrained cell growth, as well as the migratory and invasive capabilities."
genetics_overexpression_suppress	hsa-mir-502	Breast Neoplasms	27080302	"Treatment with miR-502 or downregulation of SET8 suppressed cell proliferation and cell cycle, and reduced cell migration, invasion and EMT."
genetics_overexpression_suppress	hsa-mir-15b	Glioma	27082313	"Furthermore, miR�5b inhibited proliferation and invasion, and promoted apoptosis of glioma cells while downregulating the expression of MMP� and MMP�."
genetics_overexpression_suppress	hsa-mir-199a	Breast Neoplasms	27094578	"Overexpression of miR-199a-5p reduced the mRNA and protein levels of Ets-1 in MCF-7 and MDA-MB-231 cells, whereas anti-miR-199a-5p elevated Ets-1."
genetics_overexpression_suppress	hsa-mir-125a	Retinoblastoma	27094723	The overexpression of miR-125a-5p significantly suppressed cell proliferation and tumor formation in retinoblastoma.
genetics_overexpression_suppress	hsa-mir-138	Osteosarcoma	27095063	"miR-138 inhibited cell proliferation and invasion, and promoted cell apoptosis of human osteosarcoma cells."
genetics_overexpression_suppress	hsa-mir-542	Melanoma	27107696	"Exogenous expression of miR-542-3p resulted in marked inhibition of melanoma cell migration, invasion and epithelial-mesenchymal transition (EMT) in vitro and lung metastasis in vivo."
genetics_overexpression_suppress	hsa-mir-34a	Lung Neoplasms	27109632	Systemic and local injection of ghR-form miR-34a (ghR-34a) suppressed tumor growth in a mouse model of RAS-induced lung cancer.
genetics_overexpression_suppress	hsa-mir-130b	Lupus Nephritis	27111096	overexpressing miR-130b suppressed signaling downstream from the type I IFN pathway in RMCs by targeting IFN regulatory factor 1 (IRF-1).
genetics_overexpression_suppress	hsa-mir-1180	Bladder Neoplasms	27112784	miR-1180-5p also suppressed the tumor growth in vivo significantly
genetics_overexpression_suppress	hsa-mir-9	Schizophrenia	27117414	"Overexpression of miR-9 was sufficient to ameliorate a previously reported neural migration deficit in SZ NPCs, whereas knockdown partially phenocopied aberrant migration in control NPCs."
genetics_overexpression_suppress	hsa-mir-182	Osteosarcoma	27123060	"upregulation of miRNA-182 promotes cell apoptosis and inhibits cell viability, proliferation, invasion and migration."
genetics_overexpression_suppress	hsa-let-7i	"Carcinoma, Hepatocellular"	27126374	"Let-7i was downregulated in HCC tissues, and transfection of HuH-7 with let-7i inhibited malignant cell behaviors and decreased IGF2BPs transcripts."
genetics_overexpression_suppress	hsa-mir-214	"Carcinoma, Hepatocellular"	27129291	Overexpression of miR-214 significantly attenuated cell proliferation.
genetics_overexpression_suppress	hsa-mir-429	Cervical Neoplasms	27133071	"miR-429 over-expression and inhibition on cell elongation, migration, stress fiber formation, and invasion."
genetics_overexpression_suppress	hsa-mir-370	Glioma	27138069	Overexpression of miR-370-3p showed a significant inhibitory effect on cell proliferation and accompanied cell cycle G0/G1 arrest in U251 and U87-MG cells.
genetics_overexpression_suppress	hsa-mir-199b	Colorectal Carcinoma	27145368	restoration of miR-199b considerably reduced cell invasion and migration in vitro and in vivo
genetics_overexpression_suppress	hsa-mir-223	Inflammation	27148749	The overexpression of miR-223 in both J774A.1 and peritoneal macrophages induced a phenotypic change from M1 to M2 state
genetics_overexpression_suppress	hsa-mir-133a	Glioma	27154818	"Transfection of miR-150-5p or miR-133a mimics into glioma cell lines reduced MT1-MMP expression and MMP-2 activation by these cells, and cell proliferation and invasion/migration were also suppressed by it."
genetics_overexpression_suppress	hsa-mir-150	Glioma	27154818	"Transfection of miR-150-5p or miR-133a mimics into glioma cell lines reduced MT1-MMP expression and MMP-2 activation by these cells, and cell proliferation and invasion/migration were also suppressed by it."
genetics_overexpression_suppress	hsa-mir-140	Biliary Tract Neoplasms	27155525	Ectopic expression of miR-140-5p markedly decreased SEPT2 protein concentration in BTC cells and suppressed cell proliferation and colony formation in vitro.
genetics_overexpression_suppress	hsa-mir-130a	"Leukemia, Myeloid, Chronic"	27158382	over-expression of miR-130a in A562 CML cells dramatically suppresses cell proliferation and induces cell apoptosis both in vitro and in vivo.
genetics_overexpression_suppress	hsa-mir-26a	Ovarian Neoplasms	27158389	over-expression could significantly inhibit the proliferation of ovarian cancer cells and induce their apoptosis.
genetics_overexpression_suppress	hsa-mir-1	"Squamous Cell Carcinoma, Head and Neck"	27169691	miR-1 and miR-206 significantly inhibited HNSCC cells' aggressiveness.
genetics_overexpression_suppress	hsa-mir-206	"Squamous Cell Carcinoma, Head and Neck"	27169691	restoration of miR-1 and miR-206 significantly inhibited HNSCC cells' aggressiveness.
genetics_overexpression_suppress	hsa-mir-196a	"Carcinoma, Renal Cell"	27175581	"miR�96a suppressed cell proliferation, apoptosis and migration of the 786‑O and ACHN RCC cell lines."
genetics_overexpression_suppress	hsa-mir-195	Prostate Neoplasms	27175617	"miR-195 overexpression inhibited cell proliferation, cell cycle progression and tumorigenesis via directly targeting HMGA1."
genetics_overexpression_suppress	hsa-mir-126	Thyroid Neoplasms	27175968	"upregulation of miR�26 inhibited cell proliferation, migration and invasion in thyroid cancer cells."
genetics_overexpression_suppress	hsa-mir-34a	Glioma	27176117	"Overexpression of miR�4a inhibited proliferation, and induced apoptosis of U87 cells."
genetics_overexpression_suppress	hsa-mir-497	Osteosarcoma	27176490	"upregulation of miR�97 inhibited cell proliferation, migration and invasion in osteosarcoma cell lines"
genetics_overexpression_suppress	hsa-mir-223	"Carcinoma, Lung, Non-Small-Cell"	27177336	"The overexpression of miR�23 may partially reverse the acquired resistance to epidermal growth factor receptor-TKIs, thus, providing a potential therapeutic strategy for TKI-resistant NSCLC."
genetics_overexpression_suppress	hsa-mir-191	"Carcinoma, Lung, Non-Small-Cell"	27178817	cell proliferation was notably reduced by the miR-1908 mimic transfection
genetics_overexpression_suppress	hsa-mir-126	Atherosclerosis	27180261	miR-126 up-regulation activates EPCs and ECs and contributes to vascular healing and neovessel formation
genetics_overexpression_suppress	hsa-mir-328	Cervical Neoplasms	27181358	Enforced expression of miR-328 led to a decline in the expression of endogenous TCF7L2 in cervical cancer cells.
genetics_overexpression_suppress	hsa-mir-448	"Squamous Cell Carcinoma, Oral"	27184799	Knockdown of N4BP2L1 and upregulation of miR-448 significantly reduced the invasive potential of oral squamous cell carcinoma cells.
genetics_overexpression_suppress	hsa-mir-544	"Carcinoma, Breast, Triple Negative"	27186677	"overexpression of miR-544 in triple negative breast cancer cells significantly down-regulated expressions of Bcl6 and Stat3, which in turn severely inhibited cancer cell proliferation, migration and invasion in vitro."
genetics_overexpression_suppress	hsa-mir-145	Ovarian Neoplasms	27191261	Activating miR-145 suppresses ovarian tumor growth and metastasis
genetics_overexpression_suppress	hsa-let-7c	Kidney Injury	27203438	miR-let7c-MSC therapy attenuated kidney injury
genetics_overexpression_suppress	hsa-mir-30a	Gastric Neoplasms	27208176	forced miR-30a over-expression in cancer cells can be a potential way to inhibit tumour development.
genetics_overexpression_suppress	hsa-mir-320a	Prostate Neoplasms	27212625	Restoration of mature miR�20a in PCa cell lines showed that miR�20a significantly inhibited cancer cell migration and invasion.
genetics_overexpression_suppress	hsa-mir-320	Prostate Neoplasms	27216188	An miR-320a mimic suppressed AR protein expression together with growth suppression
genetics_overexpression_suppress	hsa-mir-192	"Adenocarcinoma, Pancreatic Ductal"	27216198	overexpression of miR-192 was sufficient to reduce cell proliferation and invasion.
genetics_overexpression_suppress	hsa-mir-150	Atherosclerosis	27216461	The suppressive effects of miR-150 on macrophage foam cell formation are mediated through targeting of AdipoR2.
genetics_overexpression_suppress	hsa-mir-19a	Hypoxia	27220268	miR-19a overexpression clearly ameliorated hypoxia-induced cell death (necrosis and apoptosis)
genetics_overexpression_suppress	hsa-mir-34a	"Carcinoma, Laryngeal"	27220728	expression of miR-34a inhibited cell proliferation and migration in laryngeal carcinoma cells.
genetics_overexpression_suppress	hsa-mir-495	Glioma	27220777	restoration of hsa-miR-495 inhibited glioma cell proliferation and invasion in vitro.
genetics_overexpression_suppress	hsa-mir-18b	Melanoma	27220837	Ectopic expression of miR-18b decreased the proliferation of A375 and B16 cells
genetics_overexpression_suppress	hsa-mir-874	Colorectal Carcinoma	27221209	expression of miR-874 was downregulated in CRC tissues and cell lines
genetics_overexpression_suppress	hsa-mir-410	Breast Neoplasms	27221455	"miR-410-3p overexpression reduced cell growth, colony formation and the number of EdU-positive cells in the MDA-MB-231 cells."
genetics_overexpression_suppress	hsa-mir-181a	Cardiomegaly	27221738	"Over-expression of miR-30c or miR-181a decreased expression of p53, p21, ANP, cardiomyocyte cell size, and apoptosis in HG-treated cardiomyocytes."
genetics_overexpression_suppress	hsa-mir-375	Colorectal Carcinoma	27222350	"miR-375 inhibited proliferation, invasion and migration in DLD1 and HCT8 cells."
genetics_overexpression_suppress	hsa-mir-224	Osteosarcoma	27222381	"overexpression of miR-224 suppressed osteosarcoma cell proliferation, migration and invasion"
genetics_overexpression_suppress	hsa-mir-214	Kidney Neoplasms	27226530	miR-214 significantly blocked IGF-1R-forced renal cancer cell proliferation
genetics_overexpression_suppress	hsa-mir-137	Melanoma	27233613	Overexpression of miR-137 decreased cell proliferation and colony formation in vitro.
genetics_overexpression_suppress	hsa-mir-126	"Carcinoma, Lung, Non-Small-Cell"	27236384	"Upregulation of miR-126 resulted in the decrease of the proliferation, migration, and invasive abilities of A549 cells"
genetics_overexpression_suppress	hsa-mir-208b	Myocardial Infarction	27236543	Overexpressing miR-208b improved myocardial functions
genetics_overexpression_suppress	hsa-mir-134	"Carcinoma, Lung, Non-Small-Cell"	27241841	miR-134 suppressed tumour growth of A549 xenograft in nude mice.
genetics_overexpression_suppress	hsa-mir-17	Mesothelioma	27245839	Transfection of MPM cells with a miR-17-5p mimic or KCNMA1-specific siRNAs reduced mRNA expression of KCa1.1 and inhibited MPM cell migration.
genetics_overexpression_suppress	hsa-mir-450	Lung Neoplasms	27246609	transfection with lentivirus carrying miR�50 upregulated miR�50 expression and significantly attenuated lung cancer cell proliferation and invasion
genetics_overexpression_suppress	hsa-mir-1	"Squamous Cell Carcinoma, Esophageal"	27247259	miR� suppressed ESCC cell proliferation and increased apoptosis
genetics_overexpression_suppress	hsa-mir-124	"Carcinoma, Lung"	27251409	overexpression of miR-124 in A549 cells suppressed cell migration and invasion activity
genetics_overexpression_suppress	hsa-mir-218	"Cardiomyopathy, Hypertrophic"	27258257	Overexpression of miR-218 is sufficient to reduce hypertrophy
genetics_overexpression_suppress	hsa-mir-497	Ischemia-Reperfusion Injury	27261611	miR-497 could inhibit inflammation and apoptosis of spinal cord IR through its targets
genetics_overexpression_suppress	hsa-mir-744	Cervical Neoplasms	27261616	"up-regulation of miR-744 and down-regulation of Bcl-2 could stimulate Caspase-3 expression, promoting apoptosis of cervical cancer cells."
genetics_overexpression_suppress	hsa-mir-663a	"Carcinoma, Hepatocellular"	27261623	"miR-663a distinctly inhibited cell proliferation, migration and invasion."
genetics_overexpression_suppress	hsa-mir-411	Breast Neoplasms	27264952	Ectopic expression of miR-411-5p suppressed the breast cancer cell proliferation
genetics_overexpression_suppress	hsa-mir-26a	Osteosarcoma	27270422	miR-26a overexpression inhibits the tumor cell growth both in vitro and in vivo.
genetics_overexpression_suppress	hsa-mir-106b	Atherosclerosis	27270534	Overexpression of miR-106b-5p with miR-106b-5p mimic inhibited PTEN expression and TNF-α-induced apoptosis in HUVEC.
genetics_overexpression_suppress	hsa-mir-29b	Liver Cirrhosis	27273381	miR-29b overexpression inhibited proliferation of LX-2 cells 24 h after transfection.
genetics_overexpression_suppress	hsa-mir-320	"Carcinoma, Lung, Non-Small-Cell"	27277534	"miR�20 inhibited cell growth, migration and invasion in NSCLC cells."
genetics_overexpression_suppress	hsa-mir-375	"Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal"	27279635	"Overexpression of miR-375 led to a decreased protein level of Krüppel-like factor 4 (KLF4) and marked suppression of the proliferation and invasion, and induced apoptosis of LSCC cell line"
genetics_overexpression_suppress	hsa-mir-24	"Carcinoma, Endometrial"	27279639	Up-regulation of miR-24 inhibited the cell proliferation
genetics_overexpression_suppress	hsa-mir-205	Colon Neoplasms	27283988	miR-205 decreases cell proliferation and decreases migratory and invasive potential of colon cancer cells
genetics_overexpression_suppress	hsa-mir-486	Colorectal Carcinoma	27284245	overexpression of miR-486-5p inhibited the tumor growth and lymphangiogenesis in nude mice
genetics_overexpression_suppress	hsa-mir-210	Intervertebral Disc Degeneration	27284319	downregulation of miR-210 may promote Fas-mediated apoptosis in human IDD by regulating the expression of HOXA9.
genetics_overexpression_suppress	hsa-mir-214	Ischemia-Reperfusion Injury	27288437	Overexpression of the two miRs in cardiomyocytes mimics the effects of carvedilol
genetics_overexpression_suppress	hsa-mir-145	Liver Fibrosis	27289031	over-expression of miR-145 inhibited TGF-β1-induced the activation and proliferation of HSC-T6 cells in vitro.
genetics_overexpression_suppress	hsa-mir-210	Colorectal Carcinoma	27293381	miR-210 mediated the induction of apoptosis
genetics_overexpression_suppress	hsa-mir-153	Glioma	27295037	"Exogenous overexpression of miR-153 downregulated Rictor (mRNA and protein) and decreased p-Akt Ser473 in U87MG cells, leading to significant growth inhibition and apoptosis activation."
genetics_overexpression_suppress	hsa-let-7	Neoplasms [unspecific]	27295554	genetic rescue of Let-7 miRNA activity in Dicer1-deficient TAMs partly restored their M2-like phenotype and decreased tumour-infiltrating CTLs.
genetics_overexpression_suppress	hsa-mir-10b	Cervical Neoplasms	27296950	overexpression of miR-10b in cervical cancer cells could inhibit the cell proliferation and invasion
genetics_overexpression_suppress	hsa-mir-34b	"Leukemia, Myeloid, Acute"	27296951	the miR-34b mimicked transfection-mediated restoration of miR-34b inhibited cell viability and promoted cell apoptosis of HL-60 and OCI-AML3 cell lines.
genetics_overexpression_suppress	hsa-mir-149	"Carcinoma, Hepatocellular"	27300349	Overexpression of miR-149 or inhibition of PARP-2 expression could inhibit tumor growth but was more effective in sensitizing chemotherapy and radiotherapy in xenograft HCC animal models
genetics_overexpression_suppress	hsa-mir-196b	Lung Neoplasms	27302168	miR-196b reexpression also significantly reduced the growth of tumor xenografts.
genetics_overexpression_suppress	hsa-mir-34	Pulmonary Hypertension	27302634	"miR-34a overexpression down-regulated platelet-derived growth factor receptor alpha (PDGFRA) expression, which is a key factor in PAH development."
genetics_overexpression_suppress	hsa-mir-497	Breast Neoplasms	27303812	"Enforced miR-497 expression, accompanied with SMAD7 reduction, suppressed MDA-MB-231 and MCF-7 breast cancer cell growth"
genetics_overexpression_suppress	hsa-mir-26b	Bladder Neoplasms	27310702	Restoration of these miRNAs inhibited cell migration and invasion in BC.
genetics_overexpression_suppress	hsa-mir-674	Liver Injury	27313091	miR-674-5p might be a negative regulator in 5-LO mediated autoimmune liver injury
genetics_overexpression_suppress	hsa-mir-20a	"Carcinoma, Hepatocellular"	27313460	growth of HepG2 cells in the miR-20a mimics group was significantly inhibited
genetics_overexpression_suppress	hsa-mir-27a	"Carcinoma, Renal Cell"	27313769	upregulated miR-27a attenuated RCC tumor growth in the tumor xenograft animal model
genetics_overexpression_suppress	hsa-mir-494	Ovarian Neoplasms	27313773	Overexpression of miR-494 inhibited ovarian cancer cell proliferation by inducing apoptosis.
genetics_overexpression_suppress	hsa-mir-218	"Carcinoma, Renal Cell"	27314976	cell proliferation was suppressed in miR�18 mimic‑transfected RCC cells compared with control cells
genetics_overexpression_suppress	hsa-mir-23a	Osteoarthritis	27318087	miR-23a-3p overexpression suppresses type II collagen and aggrecan expression
genetics_overexpression_suppress	hsa-mir-206	"Carcinoma, Breast, Triple Negative"	27318091	The miR-206 mimics inhibited TNBC breast cell invasion and angiogenesis.
genetics_overexpression_suppress	hsa-let-7	Endometriosis	27320036	increased let-7f expression effectively reduced the migration of endometrial cells.
genetics_overexpression_suppress	hsa-let-7f	Endometriosis	27320036	increased let-7f expression effectively reduced the migration of endometrial cells.
genetics_overexpression_suppress	hsa-mir-137	Glioblastoma	27328425	"overexpression of miR-137 in GBM cells also inhibited cell proliferation, migration, and invasion."
genetics_overexpression_suppress	hsa-mir-148b	Breast Neoplasms	27328731	"Depleting miR-214 or elevating miR-148b blocked the dissemination of melanoma or breast cancer cells, an effect that could be accentuated by dual alteration."
genetics_overexpression_suppress	hsa-mir-148b	Melanoma	27328731	"Depleting miR-214 or elevating miR-148b blocked the dissemination of melanoma or breast cancer cells, an effect that could be accentuated by dual alteration."
genetics_overexpression_suppress	hsa-mir-30b	"Carcinoma, Hepatocellular"	27333771	Gain- and loss-of-function studies revealed that miR-30b could dramatically inhibit in vitro HCC cell migration and invasion.
genetics_overexpression_suppress	hsa-mir-141	"Carcinoma, Renal Cell, Clear-Cell"	27336447	a tumor suppressive effect of miR-141-3p and miR-145-5p by decreasing migration and invasion of RCC cells could be shown.
genetics_overexpression_suppress	hsa-mir-145	"Carcinoma, Renal Cell, Clear-Cell"	27336447	a tumor suppressive effect of miR-141-3p and miR-145-5p by decreasing migration and invasion of RCC cells could be shown.
genetics_overexpression_suppress	hsa-mir-18a	"Carcinoma, Breast, Triple Negative"	27338042	Enforced miR-18a overexpression directly led to increased autophagy in MDA-MB-231 cells
genetics_overexpression_suppress	hsa-mir-126	Age-Related Macular Degeneration	27338342	overexpression effects of miR-126 were also proven on human microvascular endothelial cells
genetics_overexpression_suppress	hsa-mir-156a	"Carcinoma, Nasopharyngeal"	27341697	synthetic miR156a mimic inhibited the EMT of NPC cells in vitro.
genetics_overexpression_suppress	hsa-mir-376c	Cervical Neoplasms	27345009	"Upregulation of miR-376c impaired cell proliferation, blocked G1/S checkpoint of cell cycle and suppressed cell invasion in vitro."
genetics_overexpression_suppress	hsa-mir-195	Colon Neoplasms	27347317	"Overexpression of miR-195-5p inhibited cellular growth, suppressed cellular migration and invasion, and led to cell cycle arrest at G1 phase in vitro."
genetics_overexpression_suppress	hsa-mir-132	Chronic Pain	27349406	Spinal administration of miR-132-3p antagonists via intrathecal (i.t.) catheters dose dependently reversed mechanical allodyina (p<0.001) and eliminated pain behavior
genetics_overexpression_suppress	hsa-mir-24	Cerebral Ischemia	27349868	miR-24 overexpression or silencing of neurocan shows an antihypoxic effect in SH-SY5Y cells.
genetics_overexpression_suppress	hsa-mir-24	Lacrimal Adenoid Cystic Carcinoma	27351203	overexpression of miR-24-3p decreased its malignant phenotype.
genetics_overexpression_suppress	hsa-mir-449a	Lung Fibrosis	27351886	miR-449a significantly reduced both the distribution and severity of lung lesions induced by silica.
genetics_overexpression_suppress	hsa-mir-410	Systemic Lupus Erythematosus	27351906	overexpression of miR-410 significantly reduced the expression levels of IL-10.
genetics_overexpression_suppress	hsa-mir-548an	Pancreatic Neoplasms	27353169	overexpression of miR-548an significantly inhibited the proliferation and invasion of pancreatic cancer cell
genetics_overexpression_suppress	hsa-mir-140	Gastric Neoplasms	27353653	miR-140 overexpression inhibited HGC-27 cell viability and colony formation and resulted in G0/G1 arrest.
genetics_overexpression_suppress	hsa-mir-139	Bladder Neoplasms	27355528	Gain-of-function studies showed that miR-139-5p and miR-139-3p significantly inhibited cell migration and invasion by BC cells.
genetics_overexpression_suppress	hsa-mir-335	Bladder Neoplasms	27356628	Overexpression of miR�35 in T24 cells inhibited cell proliferation and induced apoptosis
genetics_overexpression_suppress	hsa-mir-200b	"Carcinoma, Lung, Non-Small-Cell"	27356635	Overexpression of miR�00b significantly inhibited NSCLC cell migration and invasion.
genetics_overexpression_suppress	hsa-mir-143	"Squamous Cell Carcinoma, Esophageal"	27358073	Ectopic expression of miR-143-3p also reduced the metastatic potential of cells by selectively regulating epithelial-mesenchymal transition regulatory proteins.
genetics_overexpression_suppress	hsa-mir-330	Cutaneous Melanoma	27363653	Enforced expression of miR-330-5p inhibits malignant CMM cells proliferation and migration and led to downregulation of the TYR and PDIA3 protein.
genetics_overexpression_suppress	hsa-mir-145	"Carcinoma, Breast, Triple Negative"	27364572	Upregulating miR-145 in HCC1937 cells dramatically suppressed cell proliferation and induced G1-phase arrest
genetics_overexpression_suppress	hsa-mir-124	"Carcinoma, Lung, Non-Small-Cell"	27376157	"Overexpression of miR-124 significantly suppresses tumor cell proliferation, colony formation, migration, and induction of apoptosis in H322 and A549 cells."
genetics_overexpression_suppress	hsa-mir-26a	"Fatty Liver, Non-Alcoholic"	27377869	LV-26a-infected mice were protected from glucose dysmetabolism and showed markedly decreased total liver weight
genetics_overexpression_suppress	hsa-mir-125b	Ovarian Neoplasms	27383536	Ectopic expression of miR-125b in EOC cells significantly inhibited tumor invasion.
genetics_overexpression_suppress	hsa-mir-106a	Osteosarcoma	27383537	"Downregulation of miR-106a-5p was found in OS tissues, and upregulation of miR-106a-5p can inhibit the proliferation, migration, and invasion by targeting HMGA2 in OS cells."
genetics_overexpression_suppress	hsa-mir-210	Acute Ischemic Stroke	27390218	Lentivirus-mediated miR-210 overexpression enhanced the microvessel density and the number of neural progenitor cells in the ischemic mouse brain (P < 0.05) and improved neurobehavioral outcomes in the ischemic mouse (P < 0.05).
genetics_overexpression_suppress	hsa-mir-7	"Carcinoma, Hepatocellular"	27391479	Overexpression of miR-7 inhibited the HCC cell proliferation and invasion. Overexpression of miR-7 could suppress the direct target gene CCNE1 and PIK3CD expression.
genetics_overexpression_suppress	hsa-mir-185	Idiopathic Pulmonary Fibrosis	27392970	"Furthermore, mimics of miR-185 and miR-186 blocked transforming growth factor-β-induced collagen V overexpression and alleviated transforming growth factor-β-induced epithelial-mesenchymal transition in A549 cells and HCC827 cells."
genetics_overexpression_suppress	hsa-mir-186	Idiopathic Pulmonary Fibrosis	27392970	"Our findings suggest that attenuated expression of miR-185 and miR-186 may be responsible for collagen V overexpression during idiopathic pulmonary fibrosis, and these miRNAs may serve as pathogenesis-related biomarkers and treatment targets."
genetics_overexpression_suppress	hsa-mir-449a	"Carcinoma, Hepatocellular"	27398144	"Ectopic expression of miR-449a suppressed HCC cell proliferation, colony formation, migration and invasion."
genetics_overexpression_suppress	hsa-mir-146a	Liver Cirrhosis	27399683	"Overexpression of miR-146a-5p inhibited LPS induced pro-inflammatory cytokines secretion through down-regulating the expression levels of TLR-4, IL-1 receptor-associated kinase 1 (IRAK1), TNF receptor associated factor-6 (TRAF6) and phosphorylation of nuclear factor-kappa B (NF-κB)."
genetics_overexpression_suppress	hsa-mir-200	"Carcinoma, Breast, Triple Negative"	27402080	"miR-9 and miR-200 promoted and inhibited, respectively, the formation of vascular-like structures in vitro"
genetics_overexpression_suppress	hsa-mir-149	"Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal"	27403438	In vitro studies revealed that the exogenous expression of miRNA-149 inhibits the proliferation of human Hep-2 cells and induces cell apoptosis.
genetics_overexpression_suppress	hsa-mir-218	Chronic Obstructive Pulmonary Disease	27409149	Perturbation experiments with a miR-218-5p mimic or inhibitor demonstrated a protective role of miR-218-5p in cigarette smoke-induced inflammation and COPD.
genetics_overexpression_suppress	hsa-mir-133a	Heart Diseases [unspecific]	27411382	"Our results revealed that miR-133a mimic treatment improved the contractility of the diabetic rat's heart concomitant with upregulation of TH, cardiac NE, β-AR, and downregulation of TAT and plasma levels of NE."
genetics_overexpression_suppress	hsa-mir-141	"Carcinoma, Hepatocellular"	27412940	"Over-expression of miR-141 inhibits the proliferation, invasion and migration of hepatocellular carcinoma MHCC-97H cells"
genetics_overexpression_suppress	hsa-mir-149	Colorectal Carcinoma	27415661	"Re-expression of miR-149 could enhance the 5-FU sensitivity of 5-FU-resistant CRC cells by increasing 5-FU-inducing apoptosis, while downregulation of miR-149 could decrease the 5-FU sensitivity of parental CRC cells by decreasing 5-FU-inducing apoptosis"
genetics_overexpression_suppress	hsa-mir-18a	"Carcinoma, Hepatocellular"	27421245	"We transfected HepG2.2.15 with miR-18a mimics and CTGF siRNA, finding that upregulated miR-18a and downregulated CTGF suppress the viability and cause cell cycle arrest."
genetics_overexpression_suppress	hsa-mir-34a	Leukemia	27424989	"Induced expression of miR-34a in TIM3 positive leukemia stem cells (LSC), inhibits the clonogenic expansion, tumor progression and metastasis of leukemia."
genetics_overexpression_suppress	hsa-mir-320b	"Carcinoma, Nasopharyngeal"	27428374	"Further studies showed that overexpression of miR-320b suppressed NPC cell proliferation and enhanced mitochondrial fragmentation and apoptosis both in vitro and in vivo, while silencing of miR-320b promoted tumor growth and suppressed apoptosis."
genetics_overexpression_suppress	hsa-mir-497	Invasive Bladder Transitional Cell Carcinoma	27430325	"We also found that overexpression of miR-497 inhibited the proliferation, migration and invasion of bladder cancer cells by downregulating E2F3 (an miR-497 target gene) mRNA and protein and that siRNA against E2F3 inhibited cell proliferation, migration and invasion, which was similar to the effect of miR-497 overexpression in the BTCC cells."
genetics_overexpression_suppress	hsa-mir-338	Lung Neoplasms	27431198	"Regaining the expression of miR-338 in lung cancer cell lines significantly impaired cellular adhesion, migration, invasion and lung tumor formation in nude mice."
genetics_overexpression_suppress	hsa-mir-184	"Carcinoma, Renal Cell"	27431728	"Overexpression of pre-miR-184 changed the metabolic and proliferation features of ccRCC cells by reducing cell glucose consumption, lactate production and cell proliferation."
genetics_overexpression_suppress	hsa-mir-183	"Carcinoma, Nasopharyngeal"	27431799	"Using transient or stable transfection, we showed that ectopic expression of miR-96 and miR-183 suppressed cell growth and tumor sphere formation in NPC."
genetics_overexpression_suppress	hsa-mir-96	"Carcinoma, Nasopharyngeal"	27431799	"Using transient or stable transfection, we showed that ectopic expression of miR-96 and miR-183 suppressed cell growth and tumor sphere formation in NPC."
genetics_overexpression_suppress	hsa-mir-30a	Prostate Neoplasms	27431942	"miR�0a overexpression resulted in a significant suppression of cell growth in vitro, and reduced tumorigenicity in vivo."
genetics_overexpression_suppress	hsa-mir-200c	Lung Neoplasms	27432063	"Over expression of miR-200c could significantly inhibit cell proliferation, induce G0/G1 cell cycle arrest and induce cell apoptosis."
genetics_overexpression_suppress	hsa-mir-27a	"Squamous Cell Carcinoma, Oral"	27432214	"Intriguingly, increased expression of miR-27a-3p could significantly decrease the expression level of YAP1 as well as several epithelial to mesenchymal transition (EMT)-related molecules in OSCC cell lines, including Twist and Snail."
genetics_overexpression_suppress	hsa-mir-199a	Testicular Neoplasms	27432288	it was determined that overexpression of miR�99a�p in Ntera� cells caused suppression of cell growth and migration.
genetics_overexpression_suppress	hsa-mir-541	"Carcinoma, Lung, Non-Small-Cell"	27448300	We found that expression of miR-541-3p was decreased obviously in NSCLC tissues and plasma. Down-regulation of miR-541-3p was associated with TNM stage and postoperative survival.
genetics_overexpression_suppress	hsa-mir-26a	Prostate Neoplasms	27449037	It was confirmed that miR-26a-5p was markedly downregulated in PC tissues compared with normal controls whose reduced expression was significantly associated with metastasis and poor overall prognosis and found that miR-26a-5p was able to prevent proliferation and motility of PC cells in vitro.
genetics_overexpression_suppress	hsa-mir-613	Breast Neoplasms	27449609	"miR-613 mimics significantly inhibited the migration and invasion of breast cancer cells, whereas miR-613 inhibitors significantly increased cell migration and invasion."
genetics_overexpression_suppress	hsa-mir-455	Gastric Neoplasms	27451075	"re-expression of miR-455-5p could inhibit human GC cell proliferation and invasion, overexpression of miR-455-5p could also promote GC cell apoptosis."
genetics_overexpression_suppress	hsa-mir-338	"Carcinoma, Lung, Non-Small-Cell"	27453416	Forced expression of miR-338-3p in A549 cells led to the suppression of migration/invasion capacity and inhibition of epithelial markers.
genetics_overexpression_suppress	hsa-mir-34a	"Carcinoma, Cervical"	27456356	"While forced expression of miR-34a in CaCx and CRC cells inhibited HMGB1 mRNA and protein levels, proliferation, migration and invasion, inhibition of endogenous miR-34a enhanced these tumourigenic properties."
genetics_overexpression_suppress	hsa-mir-34a	Colorectal Carcinoma	27456356	"While forced expression of miR-34a in CaCx and CRC cells inhibited HMGB1 mRNA and protein levels, proliferation, migration and invasion, inhibition of endogenous miR-34a enhanced these tumourigenic properties."
genetics_overexpression_suppress	hsa-mir-497	Breast Neoplasms	27456360	"Further, overexpression of miR-497 not only inhibited ERRα expression but also reduced MIF level and MMP9 activity, which led to significant decreases in cell proliferation, migration, and invasion of ERα negative breast cancer."
genetics_overexpression_suppress	hsa-mir-15a	"Carcinoma, Nasopharyngeal"	27458095	"As a result, miR-15a overexpression significantly reduced cell proliferation (p��.01 or p��.001) and induced cell apoptosis (p��.001), while miR-15a suppression got the opposite result for cell proliferation and apoptosis."
genetics_overexpression_suppress	hsa-mir-451	"Carcinoma, Hepatocellular"	27461244	"In this study, overexpression of miR-451 clearly attenuated the promoting effects of HCC cells on cell proliferation, migration and tube formation of human umbilical vein endothelial cells (HUVECs)."
genetics_overexpression_suppress	hsa-mir-1207	"Carcinoma, Hepatocellular"	27461404	Overexpression of miR-1207-5p significantly suppressed the cell growth and invasion of HCC cells.
genetics_overexpression_suppress	hsa-mir-34c	Prostate Neoplasms	27461446	"In this study, we identified that miR-34C was under-expressed in the purified CD133+ PCSCs and enforced introduction of miR-34C attenuated the stemness of CD133+ PCSCs."
genetics_overexpression_suppress	hsa-mir-520a	Lymphoma	27461820	"Our data indicated that the mimics of miR�20a inhibited growth, proliferation of Raji cells and promoted its apoptosis, which was related to downregulation of AKT1, NF‑κB and ER stress response mediated by PERK/eIF2α pathway."
genetics_overexpression_suppress	hsa-mir-520a	"Lymphoma, Burkitt"	27461820	"Our data indicated that the mimics of miR�20a inhibited growth, proliferation of Raji cells and promoted its apoptosis, which was related to downregulation of AKT1, NF‑κB and ER stress response mediated by PERK/eIF2α pathway."
genetics_overexpression_suppress	hsa-mir-520a	"Lymphoma, Hodgkin"	27461820	"Our data indicated that the mimics of miR�20a inhibited growth, proliferation of Raji cells and promoted its apoptosis, which was related to downregulation of AKT1, NF‑κB and ER stress response mediated by PERK/eIF2α pathway."
genetics_overexpression_suppress	hsa-mir-520a	"Lymphoma, Non-Hodgkin"	27461820	"Our data indicated that the mimics of miR�20a inhibited growth, proliferation of Raji cells and promoted its apoptosis, which was related to downregulation of AKT1, NF‑κB and ER stress response mediated by PERK/eIF2α pathway."
genetics_overexpression_suppress	hsa-mir-132	"Carcinoma, Hepatocellular"	27467251	The tumor-suppressive role of miR-132 in HCC has been further confirmed by in vitro experiments.
genetics_overexpression_suppress	hsa-mir-203	Glioblastoma	27467502	Conversely reconstitution of miR-203 expression induced apoptosis and inhibited migratory property of glioma cells.
genetics_overexpression_suppress	hsa-mir-26a	Osteosarcoma	27468358	"Using in vitro and in vivo assays, we confirmed that miR-26a could inhibit the abilities of in vitro proliferation and suppress in vivo tumor growth in mouse model."
genetics_overexpression_suppress	hsa-mir-205	"Carcinoma, Breast"	27468619	Knock-up of miR-205 expression by transfection with its mimics promoted MDA-MB-468 cells apoptosis (P=0.006 1).
genetics_overexpression_suppress	hsa-mir-137	"Carcinoma, Gastric"	27468717	"Over expression of miR-137 could inhibit the cell migration, proliferation, and promote cell cycle arrest in G0/G1 stage in BGC-823 and SGC-7901 cell lines."
genetics_overexpression_suppress	hsa-mir-182	"Carcinoma, Renal Cell, Clear-Cell"	27468875	"Compared to the control group, cell viability, colony-forming ability, and numbers of migrated and invaded cells were significantly decreased by transfection with miR-182 mimic but were markedly increased by miR-182 inhibitor (all P < 0.05)."
genetics_overexpression_suppress	hsa-mir-148a	"Carcinoma, Ovarian"	27470550	"Moreover, cell experiments confirmed that miR-148a could inhibit proliferation, migration and invasion of ovarian cancer cells."
genetics_overexpression_suppress	hsa-mir-122	Cholangiocarcinoma	27472451	"MiR-122 overexpression reduced cell invasion and migration ability, and inhibited cell apoptosis and p53 expression. Inhibiting miR-122 caused the opposite results."
genetics_overexpression_suppress	hsa-mir-451	Glioma	27476171	"By targeting CAB 39, miRNA-451 likely triggers the LKB1/AMPK/PI3K/AKT pathway, which regulates GLUT1, to inhibit the glucose metabolism of, reduce the energy supply to, and inhibit the proliferation and invasion of glioma cells."
genetics_overexpression_suppress	hsa-mir-29b	Wound Healing	27477081	"Importantly, local delivery of miR-29b lentiviral particles inhibited HSP47 expression and collagen biosynthesis as well as suppressed angiogenesis, thus reducing scar formation in an excisional wound splinting model."
genetics_overexpression_suppress	hsa-mir-194	"Squamous Cell Carcinoma, Esophageal"	27480251	miR-194 was found to inhibit proliferation and invasion and promote apoptosis of esophageal squamous cell carcinoma cells.
genetics_overexpression_suppress	hsa-mir-203	Glioblastoma	27484906	MicroRNA-203 transfected GBM-SCs had reduced capacity for self-renewal in the cell sphere assay and increased expression of glial and neuronal differentiation markers.
genetics_overexpression_suppress	hsa-mir-26a	Vascular Hypertrophy	27485101	"Taken together, the present study suggested an anti‑hypertrophic role of miR�6a in cardiac hypertrophy, possibly via inhibition of GATA4."
genetics_overexpression_suppress	hsa-mir-101	"Carcinoma, Bladder"	27485165	"In addition, plasmid‑mediated overexpression of miR�01 and small hairpin RNA‑mediated inhibition of c‑FOS significantly inhibited the proliferation and invasive capacity of T24 cells."
genetics_overexpression_suppress	hsa-mir-610	Glioma	27485527	"Furthermore, the present study revealed that miR�10 inhibited cell growth, migration and invasion in glioma cells."
genetics_overexpression_suppress	hsa-mir-329	Osteosarcoma	27487475	"MiR-329 is able to inhibit osteosarcoma cell proliferation, promote apoptosis, and induce G0/G1 cell cycle arrest."
genetics_overexpression_suppress	hsa-mir-29a	"Carcinoma, Lung"	27488440	Restoration of miR-29a suppressed cancer cell aggressiveness and fibroblast migration.
genetics_overexpression_suppress	hsa-mir-29a	Idiopathic Pulmonary Fibrosis	27488440	Restoration of miR-29a suppressed cancer cell aggressiveness and fibroblast migration.
genetics_overexpression_suppress	hsa-mir-29b	Granular Corneal Dystrophy	27490049	Overexpression of miR-29b decreased ECM protein production in human corneal endothelial cells.
genetics_overexpression_suppress	hsa-mir-1299	"Carcinoma, Hepatocellular"	27490780	"miR-1299 overexpression inhibited cell proliferation and arrested cell cycle in G0/G1 phase analyzed by MTT assay, soft agar assay, BrdU cell proliferation assay and cell cycle assay, while miR-1299 knockdown promoted cell proliferation and accelerated G1/S transition."
genetics_overexpression_suppress	hsa-mir-15a	Melanoma	27492455	miR-15a displayed inhibitory effects on proliferation and invasiveness of several malignant melanoma cell lines.
genetics_overexpression_suppress	hsa-mir-137	"Carcinoma, Hepatocellular"	27492460	"Overexpression of miR-137 via adenoviral vector inhibited the proliferation and anchorage-independent growth of HCC cells, HepG2 and MHCC-97H."
genetics_overexpression_suppress	hsa-mir-143	Leukemia	27492780	miRNA143 transfection inhibited K562 cell growth and induced its apoptosis.
genetics_overexpression_suppress	hsa-mir-3178	"Carcinoma, Gastric"	27493095	"The condition medium from miR-3178 mimic transfected GES-1 cells could inhibit proliferation and induce apoptosis of inflammation-related gastric cancer cells SGC7901 and MGC803 by decreasing the production of inflammatory cytokines TNF-α and IL-6, which were secreted by GES-1 cells."
genetics_overexpression_suppress	hsa-mir-187	"Carcinoma, Lung, Non-Small-Cell"	27495872	Overexpression of miR-187-5p inhibited the growth and metastasis of NSCLC cells.
genetics_overexpression_suppress	hsa-mir-155	Allergy	27497617	miR-155 overexpression significantly suppressed IL-13-induced secretion of CCL11 and CCL26.
genetics_overexpression_suppress	hsa-mir-509	"Carcinoma, Lung"	27498003	"In addition, over-expression of miR-509-3-5p markedly blocked A549 cell proliferation and sensitized the cells to CIS and ADR treatment."
genetics_overexpression_suppress	hsa-let-7a	"Carcinoma, Colon"	27498032	Further studies demonstrated that over-expressed let-7a could remarkably inhibit HCT-116 and SW620 cell growth and metastasis by directly down-regulating Rhotekin (RTKN).
genetics_overexpression_suppress	hsa-mir-140	Glioma	27498787	"Restoration of miR-140 obviously suppressed glioma cell proliferation, migration and invasion."
genetics_overexpression_suppress	hsa-mir-205	"Carcinoma, Renal Cell"	27498834	"It was revealed that miR�05 promoted the apoptosis of RCC cells and suppressed their proliferation, metastasis and invasion compared with the negative control."
genetics_overexpression_suppress	hsa-mir-124	Retinoblastoma	27498908	"The ectopic expression of miR-124 in the RB cell lines (Y79 and SO-RB50) suppresses cell proliferation, migration and invasion, induced cell apoptosis in vitro."
genetics_overexpression_suppress	hsa-mir-186	"Carcinoma, Lung, Non-Small-Cell"	27498924	"Furthermore, overexpression of miR-186 suppressed lung cancer cell proliferation, migration and invasion, and induced cell apoptosis."
genetics_overexpression_suppress	hsa-mir-107	"Carcinoma, Lung"	27498977	"Function assays showed that overexpression of miR-107 suppressed cell proliferation, migration and invasion in A549 cells in vitro, and inhibited NSCLC tumor growth in vivo."
genetics_overexpression_suppress	hsa-mir-17	"Carcinoma, Ovarian"	27499367	"Forced expression of miR-17 led to markedly diminished adhesion and invasion of ovarian cancer cells in vitro, and notably reduced metastatic nodules inside the peritoneal cavity in in vivo SKOV3 xenografts model."
genetics_overexpression_suppress	hsa-mir-370	"Carcinoma, Gastric"	27499479	Upregulation of microRNA-370 promotes cell apoptosis and inhibits proliferation by targeting PTEN in human gastric cancer.
genetics_overexpression_suppress	hsa-mir-622	"Squamous Cell Carcinoma, Esophageal"	27501502	"Up-regulation of miR-622 could significantly reduce ESCC cell proliferation, enhance cell apoptosis, and impair cell invasion and migration in vitro, while down-regulation of miR-622 showed opposite effects."
genetics_overexpression_suppress	hsa-mir-223	Ischemia-Reperfusion Injury	27502281	Precursor miR-223 (pre-miR-223) transgenic mouse hearts exhibited better recovery of contractile performance over reperfusion period and lesser degree of myocardial necrosis than wild type hearts upon ex vivo and in vivo myocardial ischemia.
genetics_overexpression_suppress	hsa-mir-148b	"Carcinoma, Cervical"	27505047	"miR-148b mimics significantly decreased the cell proliferation ability and invasion ability, and statistically induced apoptosis."
genetics_overexpression_suppress	hsa-mir-139	"Carcinoma, Cervical"	27505862	"Overexpression of miR-139-3p significantly suppressed HeLa cell proliferation, migration and invasion and induced cell apoptosis."
genetics_overexpression_suppress	hsa-mir-490	"Carcinoma, Breast, Triple Negative"	27506313	Gain-of-function studies revealed that miR-490-3p-3p overexpression inhibited cell growth and invasion in both MDA-MB-231 and MDA-MB-436 TNBC cells and impaired tumorigenesis of MDA-MB-231 cells in nude mice.
genetics_overexpression_suppress	hsa-mir-122	Bladder Neoplasms	27508026	"Furthermore, miR-122 over-expression decreases bladder cancer cell migration, invasion, colony formation in vitro and slow bladder cancer growth and angiogenesis in vivo."
genetics_overexpression_suppress	hsa-mir-145	Breast Neoplasms	27508031	Wound healing assay and transwell migration assay showed that ectopic expression of miR-145 significantly inhibited breast cancer cell migration.
genetics_overexpression_suppress	hsa-mir-338	Ovarian Neoplasms	27508048	"Restoration of miR-338-3p expression in ovarian cancer cells could inhibit cell proliferation, lactate production and lactate production of ovarian cancer cells."
genetics_overexpression_suppress	hsa-mir-20a	"Squamous Cell Carcinoma, Esophageal"	27508097	"Together, our findings demonstrate that miR-17/20a suppresses cell migration and invasion of ESCC by modulating TGF-β/ITGB6 pathway."
genetics_overexpression_suppress	hsa-mir-497	"Carcinoma, Ovarian"	27513319	Overexpression of microRNA-497 suppresses cell proliferation and induces apoptosis through targeting paired box 2 in human ovarian cancer.
genetics_overexpression_suppress	hsa-mir-221	Lung Fibrosis	27513632	miRâ€?21 targets HMGA2 to inhibit bleomycin‑induced pulmonary fibrosis by regulating TGF‑Î?/Smad3-induced EMT.
genetics_overexpression_suppress	hsa-mir-106a	"Carcinoma, Bladder"	27513725	Overexpression of mir-106a suppressed the proliferation of bladder cancer cell in EJ.
genetics_overexpression_suppress	hsa-mir-34a	"Carcinoma, Gastric"	27513895	Upregulation of miR-34a enhanced the DDP sensitivity of SGC7901/DDP cells to DDP through the inhibition of cell proliferation and induction of cell apoptosis.
genetics_overexpression_suppress	hsa-mir-101	"Leukemia, Myeloid, Chronic"	27517565	These findings suggest that miR-101 acts as a tumor suppressor by downregulating Jak2 expression and sensitizing K562 cells to imatinib.
genetics_overexpression_suppress	hsa-mir-181a	Leukemia	27517749	"NP-mediated upregulation of miR-181a led to reduced proliferation, impaired colony formation and increased sensitivity to chemotherapy."
genetics_overexpression_suppress	hsa-mir-26a	"Carcinoma, Breast"	27517917	MiR-26a overexpression resulted in a reduction in cell viability that was partially recovered by inhibiting it.
genetics_overexpression_suppress	hsa-mir-148a	"Carcinoma, Gastric"	27518872	"Ectopic expression of miR-148a inhibited tumor cell proliferation and migration in vitro, and inhibited tumor formation in vivo."
genetics_overexpression_suppress	hsa-let-7b	Glioma	27520092	"upregulation of Let-7b, a member of the Let-7 microRNA family, inhibited proliferation, migration, and invasion in glioma cell lines."
genetics_overexpression_suppress	hsa-mir-34a	"Carcinoma, Breast"	27524218	MiR-34a expression was remarkably down-regulated in BC tissues and cell lines compared with normal tissues and cell lines.
genetics_overexpression_suppress	hsa-mir-132	"Carcinoma, Prostate"	27527117	"Notably, overexpression of miR-132/212 could inhibit TGF-¦Â (transforming growth factor-¦Â)-induced EMT in Vcap and Lncap cells at both the mRNA and protein expression levels."
genetics_overexpression_suppress	hsa-mir-132	Prostate Neoplasms	27527117	"Notably, overexpression of miR-132/212 could inhibit TGF-¦Â (transforming growth factor-¦Â)-induced EMT in Vcap and Lncap cells at both the mRNA and protein expression levels."
genetics_overexpression_suppress	hsa-mir-212	"Carcinoma, Prostate"	27527117	"Notably, overexpression of miR-132/212 could inhibit TGF-¦Â (transforming growth factor-¦Â)-induced EMT in Vcap and Lncap cells at both the mRNA and protein expression levels."
genetics_overexpression_suppress	hsa-mir-210	Ischemic Diseases [unspecific]	27530798	"Neonatal rats show down-regulated expression of miRNA-210 after HI, suggesting that miRNA-210 may be involved in the development and progression of hypoxic-ischemic brain edema in neonatal rats."
genetics_overexpression_suppress	hsa-mir-15a	Diabetes Mellitus	27531575	"miR-15a overexpression led to modulation toward nondiabetic levels, rather than complete inhibition of ASM and VEGF-A providing therapeutic effect without detrimental consequences of ASM and VEGF-A deficiencies"
genetics_overexpression_suppress	hsa-mir-15a	Diabetic Retinopathy	27531575	"Over-expression of miR-15a downregulated, and inhibition of miR-15a upregulated ASM and VEGF-A expression in retinal cells."
genetics_overexpression_suppress	hsa-mir-1	Heart Diseases [unspecific]	27531746	We also found that microRNAs (miRNAs) 1 and 21 bind PLN strongly and relieve PLN inhibition of SERCA to a greater extent than a similar length random sequence RNA mixture.
genetics_overexpression_suppress	hsa-mir-21	Heart Diseases [unspecific]	27531746	We also found that microRNAs (miRNAs) 1 and 21 bind PLN strongly and relieve PLN inhibition of SERCA to a greater extent than a similar length random sequence RNA mixture.
genetics_overexpression_suppress	hsa-mir-613	Ischemia-Reperfusion Injury	27534371	miR-613 inhibits I/R-induced cardiomyocyte apoptosis by targeting PDCD10 by regulating the PI3K/AKT signaling pathway
genetics_overexpression_suppress	hsa-mir-613	Myocardial Ischemic-Reperfusion Injury	27534371	miR-613 inhibits I/R-induced cardiomyocyte apoptosis by targeting PDCD10 by regulating the PI3K/AKT signaling pathway.
genetics_overexpression_suppress	hsa-mir-17	Rheumatoid Arthritis	27534557	MicroRNA-17 Suppresses TNF-B Signaling by Interfering with TRAF2 and cIAP2 Association in Rheumatoid Arthritis Synovial Fibroblasts.
genetics_overexpression_suppress	hsa-mir-200a	"Cardiomyopathy, Ischemic"	27573160	Overexpression of miR-200a protects cardiomyocytes against hypoxia-induced apoptosis by modulating the kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 signaling axis.
genetics_overexpression_suppress	hsa-mir-21	Ischemia-Reperfusion Injury	27593550	Overexpression of microRNA-21 protects spinal cords against transient ischemia.
genetics_overexpression_suppress	hsa-mir-140	Osteosarcoma	27624383	Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4.
genetics_overexpression_suppress	hsa-mir-422a	Osteosarcoma	27779704	"Overexpression of miR-422a inhibits cell proliferation and invasion, and enhances chemosensitivity in osteosarcoma cells."
genetics_overexpression_suppress	hsa-mir-21	"Carcinoma, Hepatocellular"	27793160	Overexpression of microRNA-21 strengthens stem cell-like characteristics in a hepatocellular carcinoma cell line.
genetics_overexpression_suppress	hsa-mir-126	Atherosclerosis	27827458	MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes.
genetics_overexpression_suppress	hsa-mir-93	Glaucoma	27878244	MicroRNA?93 is overexpressed and induces apoptosis in glaucoma trabecular meshwork cells.
genetics_overexpression_suppress	hsa-mir-365	"Carcinoma, Breast"	27906431	Overexpression of microRNA-365 inhibits breast cancer cell growth and chemo-resistance through GALNT4.
genetics_overexpression_suppress	hsa-mir-210	"Carcinoma, Pancreatic"	27940128	microRNA-210 overexpression inhibits tumor growth and potentially reverses gemcitabine resistance in pancreatic cancer.
genetics_overexpression_suppress	hsa-mir-34a	"Carcinoma, Colon"	28035390	"overexpression of miR-34a may inhibit the proliferation, invasion and metastasis of HCT116 cells"
genetics_overexpression_suppress	hsa-mir-1	Heart Failure	28063219	MicroRNA-1 overexpression blunts cardiomyocyte hypertrophy elicited by thyroid hormone.
genetics_overexpression_suppress	hsa-mir-142	"Carcinoma, Hepatocellular"	28081734	MicroRNA-142-5p Overexpression Inhibits Cell Growth and Induces Apoptosis by Regulating FOXO in Hepatocellular Carcinoma Cells.
genetics_overexpression_suppress	hsa-mir-27b	"Carcinoma, Lung, Non-Small-Cell"	28081743	"Overexpression of MicroRNA-27b Inhibits Proliferation, Migration, and Invasion via Suppression of MET Expression."
genetics_overexpression_suppress	hsa-mir-29a	Glioblastoma	28212562	Overexpression of miR-29a reduces the oncogenic properties of glioblastoma stem cells by downregulating Quaking gene isoform 6.
genetics_overexpression_suppress	hsa-mir-519d	"Adenocarcinoma, Lung"	28351305	Overexpression of miR-519d in lung adenocarcinoma inhibits cell proliferation and invasion via the association of eIF4H.
genetics_overexpression_suppress	hsa-mir-138	Coronary Artery Disease	28371277	Overexpression of microRNA-138 alleviates human coronary artery endothelial cell injury and inflammatory response by inhibiting the PI3K/Akt/eNOS pathway.
genetics_overexpression_suppress	hsa-mir-24	"Lymphoma, Hodgkin"	28432871	miR-24-3p Is Overexpressed in Hodgkin Lymphoma and Protects Hodgkin and Reed-Sternberg Cells from Apoptosis.
genetics_overexpression_suppress	hsa-mir-125b	"Leukemia, Myeloid, Acute"	28478034	"Overexpression of microRNA-125b inhibits human acute myeloid leukemia cells invasion, proliferation and promotes cells apoptosis by targeting NF-¦ÊB signaling pathway."
genetics_overexpression_suppress	hsa-mir-194	Adenovirus Infection	28618953	Overexpression of microRNA-194 suppresses the epithelial-mesenchymal transition in targeting stem cell transcription factor Sox3 in endometrial carcinoma stem cells.
genetics_overexpression_suppress	hsa-mir-183	"Carcinoma, Nasopharyngeal"	28631568	MiR-183 overexpression inhibits tumorigenesis and enhances DDP-induced cytotoxicity by targeting MTA1 in nasopharyngeal carcinoma.
genetics_overexpression_suppress	hsa-mir-211	Thyroid Neoplasms	28703321	"Overexpression miR-211-5p hinders the proliferation, migration, and invasion of thyroid tumor cells by downregulating SOX11."
genetics_overexpression_suppress	hsa-mir-124	Cardiovascular Diseases [unspecific]	28849090	Overexpressed microRNA-506 and microRNA-124 alleviate H2O2-induced human cardiomyocyte dysfunction by targeting kr¨¹ppel-like factor 4/5.
genetics_overexpression_suppress	hsa-mir-506	Cardiovascular Diseases [unspecific]	28849090	Overexpressed microRNA-506 and microRNA-124 alleviate H2O2-induced human cardiomyocyte dysfunction by targeting kr¨¹ppel-like factor 4/5.
genetics_overexpression_suppress	hsa-mir-34a	"Carcinoma, Cervical"	28893346	Overexpression of MicroRNA-34a-5p Inhibits Proliferation and Promotes Apoptosis of Human Cervical Cancer Cells by Downregulation of Bcl-2.
genetics_overexpression_suppress	hsa-mir-19a	Colorectal Carcinoma	29207158	Overexpression of miR-19a inhibits colorectal cancer angiogenesis by suppressing KRAS expression
genetics_overexpression_suppress	hsa-mir-150	Ischemia-Reperfusion Injury	29328381	Overexpressing microRNA-150 attenuates hypoxia-induced human cardiomyocyte cell apoptosis by targeting glucose-regulated protein-94
genetics_overexpression_suppress	hsa-mir-204	Ischemia-Reperfusion Injury	29421577	overexpression of miR-204 has a protective effect against myocardial I/R injury
genetics_overexpression_suppress	hsa-mir-145	Breast Neoplasms	29425746	miR-145 overexpression triggers alteration of the whole transcriptome and inhibits breast cancer development
genetics_overexpression_suppress	hsa-mir-143	"Carcinoma, Lung, Non-Small-Cell"	29630116	"overexpression of miR-143 downregulated cell proliferation, promoted the apoptosis, and suppressed the phosphorylation of EGFR, AKT and ERK1/2; thus, miR-143 may play a role in treatment of NSCLC to enhance therapeutic efficacy"
genetics_overexpression_suppress	hsa-mir-203	"Fatty Liver, Alcoholic"	29670525	over-expression of miR-203 inhibited the liver lipids accumulation and the progression of AFL by targeting Lipin1
genetics_overexpression_suppress	hsa-mir-27b	Atrial Fibrillation	29671258	Atrial overexpression of microRNA-27b attenuates angiotensin II-induced atrial fibrosis and fibrillation by targeting ALK5.
genetics_overexpression_suppress	hsa-mir-132	Heart Failure	29682535	Overexpression of microRNA-132 dramatically increased the antioxidant stress and antiapoptotic ability of H9C2 cells and decreased the expression of TGF-¦Â1 and smad3
genetics_overexpression_suppress	hsa-mir-140	Intervertebral Disc Degeneration	29901170	Overexpression of miR-140-5p inhibits lipopolysaccharide-induced human intervertebral disc inflammation and degeneration by downregulating toll-like receptor 4.
genetics_overexpression_suppress	hsa-mir-7	"Carcinoma, Hepatocellular"	29936764	Overexpression of miR-7 can inhibit the proliferation and invasion ability of hepatocellular carcinoma cells HepG2 by downregulating Raf1 in vitro
genetics_overexpression_suppress	hsa-mir-410	"Carcinoma, Hepatocellular"	30086463	overexpression of miR-133a suppressed biological behaviour of HCC through TGF-¦Â/Smad3 signaling pathway