AGD (the Aneurysm Gene Database ) is a database that collected genes which are article-supported to be associated with aneurysm in human, rat and mouse. An aneurysm is a localized, abnormal, weak spot on a blood vessel wall that causes an outward bulging. It can be classified into many types according to the location, including thoracic aortic aneurysm (TAA), abdominal aortic aneurysm (AAA), carotid aneurysm (CA), etc. Several types of aneurysm are with high incidence and poor prognosis. AGD curated genes in various levels, including protein, mRNA and DNA. They may indicate new therapeutic targets as well as biomarkers for diagnosis and prognosis.
Statistics:
Untill now, AGD has collected 1472 aneurysm-gene associations, including 29 types of aneurysms, 967 protein-coding genes, 29 miRNAs, 6 lncRNAs, and several other types of molecules across three species (human, rat, mouse).
History:
May 18, 2018, AGD released.
To be continued.
Contact us
Ruya Sun, 38 Xueyuan Rd, Department of Biomedical Informatics, Peking University Health Science Center, Beijing 100191, China
Email: sunruya@pku.edu.cn
Dr. Qinghua Cui, 38 Xueyuan Rd, Department of Biomedical Informatics, Peking University Health Science Center, Beijing 100191, China
Email: cuiqinghua@hsc.pku.edu.cn
More information: Homepage of Cuilab
Last Update: May-18, 2018
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You can search the entries by the following keywords:
For users who are interested in more than one gene (eg. ACE, FBN1 and ACAT1), you can:
(1) Choose the "exact" mode
(2) Input gene symbols and seperate them with ";" (eg. ACE;FBN1;ACAT1)
(3) Attention: make sure all the gene symbols you input are official and exact
symbols should in formats like: all uppercase, all lowercase, capitalize (eg.ACE;acat1;Fbn1)
Species AGD provided include:
(1) Human
(2) Rat
(3) Mouse
In the "Search" result, each entry has 9 items:
(1) Aneurysm Type You Entered
(2) Official Symbol
(3) Gene ID
(4) Description
(5) Data Source
(6) More Information
(7) Clinical Information
(8) Subcellular Location
(9) Species
Submit new entries to the database!
An aneurysm is a localized, abnormal, weak spot on a blood vessel wall that causes an outward bulging, likened to a bubble or balloon. As an aneurysm increases in size, the risk of rupture increases, leading to uncontrolled bleeding,sometimes with high risk of death. Recently, with the development of techonology, emerging evidence shows that there are many genes associated with aneurysm. Many of the genes play vital role in the progress and even prognosis of aneurysm.
AGD (the Aneurysm Gene Database) is a database collecting genes associated with different types of aneurysm. Functions of AGD and usage of each function is as follows:
[Homepage]
Visiting AGD homepage: Log on AGD at http://www.cuilab.cn/agd.
[Browse]
To browse the data collected in AGD, first, choose the menu "Browse", second, choose the aneurysm type/species you are interested in.
For users' convenience, associated genes are divided into 2 (or 3) categories: "Mutation", "Dysregulation" (,"Others").
Besides the result on the page, you can also get the result by "click to download".
[Search]
To search data in the database, click on the menu "Search", then select the species and aneurysm type. After that, type in official symbol of genes (eg.ACAT1) and select the mode of query that you want to use. Here, users are allowed to search for several genes at one time (eg. ACE;FBN1;ACAT1). If you have finished all the steps above, just click the "search" buttom, then you'll get the result. If you want to try a new search, just click on "reset".
Each “search” will return entries including the following 9 items:
(1) Aneurysm Type
(2) Official Symbol You Entered
(3) Gene ID
(4) Description
(5) Data Source
(6) More Information
(7) Clinical Information
(8) Subcellular Location
(9) Species
[Download]
To download data from AGD, select the menu "Download". AGD provides two formats of files for download, txt and excel, just choose the format you prefer. The files are differnted in the species they collect, the first one "all" covers dataset of all the three species (human, mouse, rat) collected in AGD.
[Submit]
To submit new entries to the database, select the menu "Submit". The users need to input their data into corresponding blanks and then submit the query. We will further curate the submitted information to determine whether to add the new entries to the database or not.
Currently, all data in AGD is free only for academic users and please contact Dr. Qinghua Cui for commercial using.
If there is any comment or suggestion, please let us know, you can contact Ruya Sun at sunruya@pku.edu.cn or contact Dr. Qinghua Cui at cuiqinghua@hsc.pku.edu.cn.
Citation: Sun R, Cui C, Zhou Y, and Cui Q. AGD: Aneurysm Gene Database. DATABASE 2018 (accepted).
Publish Date: 2018-5-18